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  • Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic
    Neurol. Sci. (IF 2.415) Pub Date : 2020-08-06
    Nida Fatima, Maher Saqqur, Fatima Qamar, Samia Shaukat, Ashfaq Shuaib

    Corona virus disease 2019 (COVID-19) pandemic has become a globally challenging issue after its emergence in December 2019 from Wuhan, China. Despite its common presentation as respiratory distress, patients with COVID-19 have also shown neurological manifestation especially stroke. Therefore, the authors sought to determine the etiology, underlying risk factors, and outcomes among patients with COVID-19

  • Persistence and regredience of intraspinal fluid collection determine symptom control in intracranial hypotension syndrome
    Neurol. Sci. (IF 2.415) Pub Date : 2020-08-03
    Gereon Johannes Schnellbächer, Michael Mull, Arno Reich

    Background and purpose An intraspinal fluid collection (ISFC) can be observed on spinal MRI in cases of intracranial hypotension syndrome (IHS). The goal of this study was to analyze the possible persistence of ISFC after therapy and its correlation to clinical disease activity and secondary complications. Materials and methods Twenty patients in our database of 57 patients, who were treated for IHS

  • Quality of life in neuro-Behçet’s disease: a cross-sectional study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-08-02
    Müge Kuzu Kumcu, Batuhan Bakırarar, Canan Yücesan

    Purpose Behçet’s disease (BD) is a multisystemic perivasculitis with recurrent oral aphthous ulcers, genital ulcers, and eye involvement which was first described in 1937. Neurological involvement in BD patients is referred to as neuro-Behçet’s disease (NBD). Studies have shown that BD worsens quality of life. However, there is no study that conducts a head-to-head comparison of quality of life between

  • Electroencephalography during SARS-CoV-2 outbreak: practical recommendations from the task force of the Italian Society of Neurophysiology (SINC), the Italian League Against Epilepsy (LICE), and the Italian Association of Neurophysiology Technologists (AITN)
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-21
    Antonello Grippo, Giovanni Assenza, Maenia Scarpino, Lidia Broglia, Rosalia Cilea, Carlo Andrea Galimberti, Giovanni Lanzo, Roberto Michelucci, Laura Tassi, Maurizio Vergari, Vincenzo Di Lazzaro, Oriano Mecarelli

    Background During COVID-19 lockdown, non-urgent medical procedures were suspended. Grade of urgency of electroencephalography (EEG) may vary according to the clinical indication, setting, and status of infection of SARS-CoV-2 virus. “Italian Society of Clinical Neurophysiology” (SINC), “Italian League Against Epilepsy” (LICE), and the “Italian Association of Neurophysiology Technologists” (AITN) aimed

  • Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-20
    Silvia Benemei, Chiara Lupi, Francesco De Cesaris, Niccolò Lombardi, Alessandra Bettiol, Alberto Chiarugi, Pierangelo Geppetti, Valentina Galli, Chiara Pracucci, Brunella Occupati, Guido Mannaioni

    Objectives A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease. Evidence suggests that in selected patients, chronic opioids may be a valuable therapeutic option for RCM. The aim of the present study was to evaluate the effectiveness and safety of prophylaxis with low-dose methadone (LDM) in patients affected by RCM with continuous

  • Evaluation of serum uric levels in migraine
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-20
    Tamer Yazar, Hülya Olgun Yazar, Ali Aygün, Volkan Karabacak, Yavuz Altunkaynak, Dursun Kirbaş

    Objective In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine). Method The study included 300 migraine patients and 150 healthy controls for a total of 450 individuals. Migraine and subtypes were diagnosed according to International Classification of Headache Disorders-2013 criteria

  • Lentiform fork sign in a patient with systemic lupus erythematosus
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-18
    Vasilios C. Constantinides, Christina Deligianni, Antonios Dimitrakopoulos, George P. Paraskevas, Elisabeth Kapaki

    The “lentiform fork sign” is a rare MRI sign which affects the posterior limb of the internal capsule, the external capsule, and extends posteriorly to form a fork-like appearance. It has been reported exclusively in disorders with metabolic acidosis, such as uremic encephalopathy, mitochondrial disorders, methanol/ethylene glycol intoxication, etc. It is considered to represent vasogenic edema and

  • Determinant factors of sarcopenia in individuals with Parkinson’s disease
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-18
    Marcella Campos Lima da Luz, Gleyce Kelly Araújo Bezerra, Amdore Guescel C. Asano, Maria da Conceição Chaves de Lemos, Poliana Coelho Cabral

    Objective Evaluate the occurrence of sarcopenia and determinant factors in individuals with Parkinson’s disease (PD) in a city in northeastern Brazil. Methods Case series with 77 men and women (adults and older adults) with PD. The risk of sarcopenia was determined using the SARC-F and SARC-CalF screening tools. The diagnosis of sarcopenia was based on the new consensus published by the European Working

  • Pearl and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability—part II
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-18
    Marina de Tommaso, Viviana Betti, Tommaso Bocci, Nadia Bolognini, Francesco Di Russo, Francesco Fattapposta, Raffaele Ferri, Sara Invitto, Giacomo Koch, Carlo Miniussi, Francesco Piccione, Aldo Ragazzoni, Ferdinando Sartucci, Simone Rossi, Massimiliano Valeriani

    This review focuses on new and/or less standardized event-related potentials methods, in order to improve their knowledge for future clinical applications. The olfactory event-related potentials (OERPs) assess the olfactory functions in time domain, with potential utility in anosmia and degenerative diseases. The transcranial magnetic stimulation-electroencephalography (TMS-EEG) could support the investigation

  • Screening for depression in movement disorders clinic
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-17
    Parviz Bahadoran, Rita Varela, Andrea De Angelis, Dominic Paviour, Niruj Agrawal

    Background Depression is the most common, though often under-recognised, neuropsychiatric disturbance in movement disorders (MD). Objective This study aimed to establish whether a briefer screening measure such as a visual analogue screening measure (Emotions Thermometer) or Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) could be a potentially suitable screening tool for depression

  • Proposed minimal essential co-expression and physical interaction networks involved in the development of cognition impairment in human mid and late life
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-16
    Zahra Salehi, Masoud Arabfard, Omid Sadatpour, Mina Ohadi

    Aim The aim of this study was to identify the minimal essential co-expression and physical interaction networks involved in the development of cognition impairment in human mid and late life. Methods We searched the Online Mendelian Inheritance in Man (OMIM) database to extract the validated human genes annotated (until March 2020) for five major disorders of pathophysiological overlap and sequential

  • Increased rapid eye movement density in Chinese patients with Parkinson’s disease and RBD
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-16
    Jun Zhu, Liyu Lu, Min Zhong, Xu Jiang, Zhuang Wu, Jingde Dong, Yang Pan, Li Zhang

    Objective Impaired rapid eye movement sleep is common among patients with Parkinson’s disease (PD). However, information on rapid eye movement density (REM) among PD patients is currently lacking. The current study sought to characterize REM density in PD patients and to examine the associations between REM density sleep parameters and clinical manifestations. Participants and methods We retrospectively

  • Validation of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale in Poland and its reliability in conditions of the medical experiment
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-16
    Stanisław Maksymowicz, Paula Kukołowicz, Tomasz Siwek, Agnieszka Rakowska

    Introduction Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is a basic tool for monitoring disease progression in amyotrophic lateral sclerosis (ALS). This study analyses the reliability of the Polish version of the ALSFRS-R as a tool to assess the health condition of patients with ALS and presents experience related to the use of this tool in monitoring the effects of experimental

  • Neuropathy and primary headaches affect different subgroups of inflammatory bowel disease patients
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-15
    Antônio M. F. Leitão, Howard L. Ribeiro Junior, Davi F. Araújo, Lúcia L. B. C. Braga, Marcellus H. L. P. Souza, Alzira M. C. Barbosa, Antônio B. Viana Júnior, Francisco De A. A. Gondim

    Background Peripheral neuropathies (PN) and primary headaches (PH) are common comorbidities in inflammatory bowel disease (IBD) patients. We aimed to evaluate whether PN and PH affect the same subgroups of IBD patients. Methods Since 2004, we established a cohort study to evaluate neurological diseases in IBD patients. Over 2 years, all consecutive (N = 155) IBD patients (either Crohn’s disease (CD)

  • Management of antiepileptic drug–induced nutrition-related adverse effects
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-14
    Maryam Safahani, Hadi Aligholi, Ali A. Asadi-Pooya

    Although antiepileptic drugs (AEDs) are mainstay of the treatment of epilepsy, they are associated with significant adverse effects. The present study reviews the adverse effects of AEDs on some of the nutrition-related issues, including bone health, body weight, glucose and lipid metabolism, vitamin homeostasis, antioxidant defense system, and pregnancy. This paper also provides some nutritional recommendations

  • Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-14
    Niveditha Manjunath, Prerana Jha, Jyotsna Singh, Amol Raheja, Kavneet Kaur, Ashish Suri, Ajay Garg, Mehar Chand Sharma, Chitra Sarkar, Madan Mohan, Kalaivani Mani, Vaishali Suri

    Purpose H3K27M mutant diffuse midline gliomas (DMGs) are considered grade IV irrespective of histological features and have dismal prognosis. We evaluated clinico-pathologic, radiological, and molecular characteristics of DMGs across all ages. Methods One twenty-six DMGs were identified over 10 years. Immunohistochemistry was done for H3K27M, ATRX, IDH1, and p53, and Sanger sequencing performed for

  • Giovanni Mingazzini (1859–1929) and his opposition to Pierre Marie’s conception of motor aphasia
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-13
    Francesco Brigo, Raffaele Nardone

    This article describes the contribution of Giovanni Mingazzini (1859–1929), the “Father of Italian Neurology,” in the description of the subcortical structures involved in motor aphasia and his opposition to Pierre Marie’s (1853–1940) conception of aphasia. In one of the most famous controversies in the history of neurology, the French neurologists Joseph Jules Dejerine (1849–1917), Augusta Dejerine-Klumpke

  • Stroke-like migraine attacks after radiation therapy (SMART) syndrome—a case series and review
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-13
    Urvish K. Patel, Khush Patel, Preeti Malik, Ahmed Elkady, Nidhi Patel, Abhishek Lunagariya

    Introduction Cranial irradiation is used both prophylactically and for the treatment of brain tumors. There are various complications associated with it. The rare complication of stroke-like migraine attacks after radiation therapy (SMART) syndrome usually occurs several years after radiation therapy but is a reversible phenomenon. It usually presents with headaches, seizures, or other focal neurological

  • Urinary kynurenine as a biomarker for Parkinson’s disease
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-13
    Jia-he Bai, Ya-li Zheng, Yong-peng Yu

    Objective To examine whether urine kynurenine (KYN) levels were associated with early-stage Parkinson’s disease (PD), as well as the value of urine KYN as a potential biomarker in early-stage PD. Method Eighty-two participants including 41 PD patients and 41 healthy controls were enrolled into this study. Urine KYN levels were measured with a KYN enzyme-linked immunoassay kit. In order to explore the

  • A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-12
    Davide Sangalli, Valeria Polonia, Daniele Colombo, Vittorio Mantero, Marco Filizzolo, Chiara Scaccabarozzi, Andrea Salmaggi

    The sudden worldwide outbreak of Coronavirus Disease 2019 (COVID-19) has certainly provided new challenges in the management of acute ischaemic stroke, and the risk-benefit ratio of intravenous thrombolysis in COVID-19 positive patients is not well known. We describe four COVID-19 patients treated with intravenous thrombolysis for acute ischaemic stroke. Although rt-PA administration is the main therapeutic

  • Patient characteristics with negative diffusion-weighted imaging findings in acute lateral medullary infarction
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-12
    Junichiro Ohira, Nobuyuki Ohara, Takuya Hinoda, Takeshi Morimoto, Nobuo Kohara

    Background Diffusion-weighted imaging (DWI) on magnetic resonance imaging (MRI) shows limited sensitivity in the acute-phase brainstem infarctions, including lateral medullary infarction (LMI), and the detailed characteristics of acute LMI patients with initially negative DWI-MRI findings have not been reported previously. Therefore, we aimed to investigate the differences in the backgrounds or symptoms

  • DAPT score: predictive model of dual-antiplatelet therapy for acute cerebral infarction
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-12
    Yang Liu, Jia Yang, Panpan Jiang, Shan Wang, Mingming Wang, Mayan Wang, Tiankang Guo, Jianxiong Liu

    Objective This article analyzes factors which affect the prognosis of acute cerebral infarction (ACI) patients receiving a course of antiplatelet therapy with aspirin and (or) clopidogrel for 14 days and proposes a simple grading scale to predict the clinical effectiveness of these drugs. Methods We evaluated the association between ACI and risk factor (univariate analysis) on at day 14 post admission

  • The quality of measurement properties of neurocognitive assessment in brain tumor clinical trials over the last 30 years: a COSMIN checklist-based approach
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-12
    Maria De Martino, Barbara Santini, Giovanna Cappelletti, Annapina Mazzotta, Matteo Rasi, Giorgia Bulgarelli, Luciano Annicchiarico, Alessandro Marcocci, Andrea Talacchi

    Purpose To provide an exhaustive review of the neuropsychological examination as conducted in brain tumor clinical trials over the last 30 years and to provide objective ratings about the reliability and suitability of such tests in neurooncological research and clinical practice. Methods Methodologies and tools provided by the COnsensus-based Standards for the selection of health Measurement INstruments

  • Frequency and outcome of olfactory impairment and sinonasal involvement in hospitalized patients with COVID-19
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-12
    Maryam Jalessi, Mitra Barati, Mohammad Rohani, Elahe Amini, Anis Ourang, Zahra Azad, Farideh Hosseinzadeh, Francesco Cavallieri, Reza Ghadirpour, Franco Valzania, Corrado Iaccarino, Arman Ahmadzadeh, Mohammad Farhadi

    Background Olfactory dysfunction has shown to accompany COVID-19. There are varying data regarding the exact frequency in the various study population. The outcome of the olfactory impairment is also not clearly defined. Objective To find the frequency of olfactory impairment and its outcome in hospitalized patients with positive swab test for COVID-19. Methods This is a prospective descriptive study

  • Effects of acute mild hypoxia on cerebral blood flow in pilots
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-11
    Jie Liu, Shujian Li, Long Qian, Xianrong Xu, Yong Zhang, Jingliang Cheng, Wanshi Zhang

    Background Pilots often face and need to overcome a diverse range of unfavorable conditions, of which hypoxic exposure is the most common. Studies have reported that hypoxia can induce a decrease in cerebral blood flow (CBF) in the brains of both humans and animals. Hypoxia and the associated cerebral hemodynamic changes can contribute to cognitive performance deficits that may endanger flight safety

  • Medulloblastoma of the adult: results from a multicenter retrospective study by AINO (Italian Association of Neuro-Oncology) and SIN (Italian Society of Neurology)
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-11
    Paola Gaviani, Giorgia Simonetti, Roberta Rudà, Federica Franchino, Giuseppe Lombardi, Marco Possanzini, Sara Squintu, Veronica Villani, Mariaausilia Teriaca, Francesco Cavallieri, Maria Caffo, Andrea Salmaggi, Andrea Bianco, Elena Anghileri, Mariangela Farinotti, Irene Tramacere, Antonio Silvani

    Introduction Medulloblastoma (MB) is the most common primary malignant intracranial tumor in childhood, but it is very rare in adults, and for this reason, the optimal treatment has not yet been defined. We designed a multicentric study in order to define relevant outcome measures for future prospective studies. Materials and methods The project involved 10 Italian centers. The database shared among

  • Multimodal evaluation of the cerebrovascular reserve in Neurofibromatosis type 1 patients with Moyamoya syndrome
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Alessandra D’Amico, Lorenzo Ugga, Sirio Cocozza, Sara Maria delle Acque Giorgio, Domenico Cicala, Claudia Santoro, Daniela Melis, Giuseppe Cinalli, Arturo Brunetti, Sabina Pappatà

    Purpose Moyamoya syndrome (MMS) is a rare intracranial arterial vasculopathy which can occur in neurofibromatosis type 1 (NF1) disease, representing a cause of cerebrovascular reserve (CVR) impairment, possibly leading to ischemic stroke. Here, we evaluated noninvasive imaging techniques used to assess CVR in MMS patients, describing clinical and imaging findings in patients affected by MMS-NF1. Methods

  • Chronic immune sensory polyradiculopathy (CISP): First juvenile case description
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Stefano Sotgiu, A. Minutolo, A. Carta, G. Puseddu, P. E. Doneddu, E. Nobile-Orazio

    In its typical presentation, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) occurs more often in old males as a progressive/recurrent motor and sensory nerve dysfunction with tendon areflexia. However, CIDP has also atypical clinical presentations, including pure sensory neuropathies, among which chronic immune sensory polyradiculopathy (CISP) accounts for only 0.5% of all CIDP, with

  • Pupil dilation as an indicator of future thinking
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Mohamad El Haj, Ahmed A. Moustafa

    Background The pupil typically dilates in reaction to cognitive load. In this study, we, for the first time, investigated whether future thinking (i.e., the ability to generate hypothetical scenarios in the future) would result in pupil dilation. Methods We recorded pupil dilation of participants during two conditions: past and future thinking. In past thinking, we invited participants to retrieve

  • Modulation of the excitatory phase following the cutaneous silent period by vibration
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Ayşegül Gündüz, Selahattin Ayas, Markus Kofler, Şenay Aydın, Meral Erdemir Kızıltan

    Introduction The post-inhibition excitatory phase (E3) of the cutaneous silent period (CSP) is attributed to the resynchronization of motoneuron activity following the inhibitory period but there is also evidence that a somatosensory startle reflex may contribute to this phase. We hypothesized that the startle reflex component contained in E3 will decrease during vibration. Methods Sixteen healthy

  • Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Baiyuan Yang, Chenghui Yang, Junwei Ren, Chengqing Zhong, Keting Liu, Liusha Zhao, Li Li, Han Wang, Mingling Zhu, Zhenfang Lin

    Background Amyotrophic lateral sclerosis (ALS), one of the motor neuron diseases, appears to be caused by genetic and environmental risk factors. However, the influence of Pro34Ser variant of CHCHD10 gene in increasing risk of ALS remains indeterminate. This study conducted a meta-analysis to establish the association between Pro34Ser variant of CHCHD10 gene and risk of ALS. Methods PubMed, Web of

  • Selective defects of face familiarity associated to a left temporo-occipital lesion
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Costanza Papagno, Edoardo Barvas, Marco Tettamanti, Guido Gainotti

    Acquired prosopagnosia is usually a consequence of bilateral or right hemisphere lesions and is often associated with topographical disorientation and dyschromatopsia. Left temporo-occipital lesions sometimes result in a face recognition disorder but in a context of visual object agnosia with spared familiarity feelings for faces, usually in left-handers. We describe a patient with a left temporo-occipital

  • Ischemic stroke in young adults in Bogota, Colombia: a cross-sectional study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-10
    Maria Paula Aguilera-Pena, Andres Felipe Cardenas-Cruz, Ivan Baracaldo, Elkin Garcia-Cifuentes, Maria Isabel Ocampo-Navia, Elza Juliana Coral

    Background There has been an increase in the incidence of ischemic stroke in young adults. It is believed that it is due to the increase in traditional cardiovascular risk factors. This change has affected the quality of life of young adults. Aims To describe the most common etiologies and risk factors in patients aged ≤ 50 who had ischemic stroke between 2011 and 2018. Methodology A cross-sectional

  • Serum level of lipoprotein-associated phospholipase A2 is a potential biomarker of vertebrobasilar dolichoectasia and its progression to cerebral infarction
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-09
    Yuan Liu, Jinhua Zhu, Xuhui Deng, Zhi Yang, Chunchun Chen, Shuxuan Huang, Lue Chen, Ying Ma, Weifeng Lin, Feiqi Zhu

    Background There are no effective therapies to prevent the occurrence and progression of vertebrobasilar dolichoectasia (VBD). In this study, we investigated the relationship between serum levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the occurrence and progression of VBD. Methods Sixty (60) cases without VBD and ischemia stroke were considered as Group A, 100 cases with VBD were

  • Is Guillain-Barrè syndrome triggered by SARS-CoV-2? Case report and literature review
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-09
    Edoardo Agosti, Andrea Giorgianni, Francesco D’Amore, Gabriele Vinacci, Sergio Balbi, Davide Locatelli

    Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for coronavirus disease 2019 (COVID-19). Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19. We reported a case of COVID-19 patient with acute monophasic Guillain-Barré syndrome (GBS), and a literature

  • The role of transcranial sonography in differentiation of dementia subtypes: an introduction of a new diagnostic method
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-08
    Mostafa Almasi-Dooghaee, Mohammad Rohani, Atefeh Imani, Shabnam Nadjafi, Babak Zamani

    Purpose Transcranial sonography (TCS) is increasingly used for the diagnosis of neurodegenerative disorders. We assessed the role of third ventricle width (TVW), midbrain area (MA), and midbrain circumference (MC) by TCS for diagnosis and differentiation of dementia. Methods A cross-sectional study was designed in 59 patients with dementia including 19 patients with Alzheimer’s disease (AD), 10 Dementia

  • Suicide and suicide attempts after subthalamic nucleus stimulation in Parkinson’s disease: a systematic review and meta-analysis
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-08
    Yaji Xu, Baiyuan Yang, Chuanli Zhou, Meijuan Gu, Juan Long, Fang Wang, Yongyun Zhu, Bin Liu, Hui Ren, Xinglong Yang

    Background Deep-brain stimulation is a well-established, effective treatment for patients with advanced Parkinson’s disease. Recent studies examining rates of suicide attempts and suicides after deep-brain stimulation in the bilateral subthalamic nucleus have reported varying results. Using this systematic review and meta-analysis, we aim to obtain a comprehensive understanding of suicidality in Parkinson’s

  • Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-08
    Jong-moon Hwang, Ju-Hyun Kim, Jin-Sung Park, Min Cheol Chang, Donghwi Park

    Introduction In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death. Methods In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic

  • The impact of FLAIR vascular hyperintensity on clinical severity and outcome
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-08
    Guangshuo Li, Rui Huang, Guorong Bi

    Background The clinical significance of fluid-attenuated inversion recovery vascular hyperintensity (FVH) has not been clarified. The aim of this study was to clarify the effects of FVH on the clinical severity and long-term prognosis of patients with proximal middle cerebral artery (MCA) occlusion or severe stenosis. Method Because their clinical and imaging data is not accessible, we excluded the

  • Frameless stereotaxy in subthalamic deep brain stimulation: 3-year clinical outcome
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-07
    Carla Piano, Francesco Bove, Delia Mulas, Anna Rita Bentivoglio, Beatrice Cioni, Tommaso Tufo

    Background In most centers, the surgery of deep brain stimulation (DBS) is performed using a stereotactic frame. Compared with frame-based technique, frameless stereotaxy reduces the duration of surgical procedure and patient’s discomfort, with lead placing accuracy equivalent after the learning curve. Although several studies have investigated the targeting accuracy of this technique, only a few studies

  • Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-06
    Stefania Bianchi-Marzoli, Silvia Fenu, Lisa Melzi, Chiara Benzoni, Filippo Antonazzo, Eugenia Tomas Roldan, Laura Farina, Gemma Tremolada, Elena Mauro, Viviana Pensato, Cinzia Gellera, Davide Pareyson, Ettore Salsano

    Background Adrenoleukodystrophy (ALD) encompasses different neurological phenotypes, ranging from the most severe cerebral forms (C-ALD) to the less severe adrenomyeloneuropathy (AMN). As visual system can be varyingly involved, we aimed at exploring whether optical coherence tomography (OCT) may detect retinal abnormalities and their longitudinal changes in adult ALD patients. Methods In this cross-sectional

  • Spontaneous remission of infantile spasms following rotavirus gastroenteritis
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-06
    Xiang-Dong Zeng, Wen-Guang Hu

    Epileptic seizures might be provoked and/or exacerbated by fever or viral infection in children with epilepsy. However, this is not true for infantile spasms; in this study, we report three cases with infantile spasms became seizure free within 2–5 days following rotavirus gastroenteritis without an exchange or addition of antiepileptic drugs, and hypsarrhythmia evolved to diffuse slow waves or localized

  • Long-term efficacy and cognitive effects of bilateral hippocampal deep brain stimulation in patients with drug-resistant temporal lobe epilepsy
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-06
    Shu Wang, Meng Zhao, Tianfu Li, Chunsheng Zhang, Jian Zhou, Mengyang Wang, Xiongfei Wang, Kaiqiang Ma, Guoming Luan, Yuguang Guan

    Purpose Temporal lobe epilepsy patients treated with hippocampal deep brain stimulation (Hip-DBS) have rarely been reported before. Preoperative and postoperative cognitive function is seldom analyzed. Methods Seven patients with drug-resistant temporal lobe epilepsy were included in this study. Bilateral Hip-DBS was performed in these patients. The stimulator was activated 1 month after the implantation

  • Effect of lockdown on the management of ischemic stroke: an Italian experience from a COVID hospital
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-06
    Giovanni Frisullo, Valerio Brunetti, Riccardo Di Iorio, Aldobrando Broccolini, Pietro Caliandro, Mauro Monforte, Roberta Morosetti, Carla Piano, Fabio Pilato, Paolo Calabresi, Giacomo Della Marca

    Objective To evaluate the impact of the lockdown measures, consequent to the outbreak of COVID-19 pandemic, on the quality of pre-hospital and in-hospital care of patients with acute ischemic stroke. Methods This is an observational cohort study. Data sources were the clinical reports of patients admitted during the first month of lockdown and discharged with a confirmed diagnosis of stroke or TIA

  • Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-06
    Rong Wang, Zuohua Tang, Tingting Liu, Xinghuai Sun, Lingjie Wu, Zebin Xiao

    Purpose To explore the alterations of spontaneous neuronal activity and functional connectivity pattern using fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) in patients with primary angle-closure glaucoma (PACG) and fALFF relationship with the glaucoma clinical indices. Materials and methods Forty-two PACG patients and 21 normal controls were enrolled in

  • Early neurological manifestations of hospitalized COVID-19 patients
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-02
    Veria Vacchiano, P. Riguzzi, L. Volpi, M. Tappatà, P. Avoni, G. Rizzo, L. Guerra, S. Zaccaroni, P. Cortelli, R. Michelucci, R. Liguori

    Introduction Neurological manifestations can occur during coronavirus disease 19 (COVID-19). Several pathogenic mechanisms have been hypothesized, without conclusive results. In this study, we evaluated the most frequent neurological symptoms in a cohort of hospitalized COVID-19 patients, and also investigated the possible relationship between plasmatic inflammatory indices and olfactory disorders

  • Real-time assessment of COVID-19 prevalence among multiple sclerosis patients: a multicenter European study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-02
    Gloria Dalla Costa, Letizia Leocani, Xavier Montalban, Ana Isabel Guerrero, Per Soelberg Sørensen, Melinda Magyari, Richard J. B. Dobson, Nicholas Cummins, Vaibhav A. Narayan, Matthew Hotopf, Giancarlo Comi

    We assessed the prevalence and impact of COVID-19 among multiple sclerosis (MS) patients across Europe by leveraging participant data collected as part of the ongoing EU IMI2 RADAR-CNS major programme aimed at finding new ways of monitoring neurological disorders using wearable devices and smartphone technology. In the present study, 399 patients of RADAR-MS have been included (mean age 43.9 years

  • Associations of truncal body composition with cognitive status in patients with dementia
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-02
    Seonah Kim, Jin Ok Kim, Kyoung Ja Kwon, Seol-Heui Han, Yeonsil Moon

    Backgound Central obesity in midlife is a risk factor of cognitive decline and dementia, and also one of the factors that make cognitive functions deteriorate rapidly. Objective The objective of this study is to investigate the relationship between truncal body composition (fat and muscle) and cognitive impairment in patients with dementia. Methods A total of 81 female over 60 years of age with probable

  • Ultrasonography of cervical nerve roots: cross-sectional reference values according to age
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-02
    Marta Drake-Pérez, Ana L. Pelayo-Negro, José R. Sánchez-de la Torre, José Berciano, Elena Gallardo

    Introduction The aim of this study is to describe the normal cross-sectional area (CSA) and appearance of cervical nerve roots in ultrasound, correlating it to age and other patient somatic parameters. Methods One hundred healthy volunteers were included. We aimed to achieve uniform representation throughout all age groups. Ultrasound of the cervical nerve roots was performed bilaterally. CSA and margins

  • Impact of quarantine due to COVID infection on migraine: a survey in Genova, Italy
    Neurol. Sci. (IF 2.415) Pub Date : 2020-07-01
    Italo Carlo Parodi, Maria Gabriella Poeta, Andrea Assini, Erika Schirinzi, Paola Del Sette

    Quarantine is a well-known risk factor for psychological and psychiatric disturbances. We evaluated burden of migraine during lockdown due to COVID 19 pandemia. Forty-nine subjects followed in our headache clinic for migraine were evaluated for migraine burden by means of global assessment of migraine severity (GAMS) and visual analogue scale (VAS) by phone interview. Moreover, depression and anxiety

  • Clinical characteristics and long-term prognosis of relapsing anti- N -methyl- d -aspartate receptor encephalitis: a retrospective, multicenter, self-controlled study
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-29
    Wei Zeng, Liming Cao, Jinou Zheng, Lu Yu

    Objective To analyze the clinical profile and long-term prognosis of relapsing anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Method This is a retrospective, multicenter, self-controlled study of 10 patients with relapsing anti-NMDAR encephalitis. Relapse was defined as new psychiatric or neurologic syndrome unexplainable by other causes that improved after immunotherapy. Results The main

  • Management of COVID-19 in people with epilepsy: drug considerations
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-27
    Ali A. Asadi-Pooya, Armin Attar, Mohsen Moghadami, Iman Karimzadeh

    People with epilepsy (PWE) are neither more likely to be infected by the coronavirus nor are they more likely to have severe COVID-19 manifestations because they suffer from epilepsy. However, management of COVID-19 in PWE may be more complicated than that in other individuals. Drug-drug interactions could pose significant challenges and cardiac, hepatic, or renal problems, which may happen in patients

  • CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-26
    Vasileios Siokas, Emmanouil Karampinis, Athina-Maria Aloizou, Alexios-Fotios A. Mentis, Panagiotis Liakos, Dimitra Papadimitriou, Ioannis Liampas, Grigorios Nasios, Dimitrios P. Bogdanos, Georgios M. Hadjigeorgiou, Efthimios Dardiotis

    Background Genetic variability is considered to confer susceptibility to amyotrophic lateral sclerosis (ALS). Oxidative stress is a significant contributor to ALS-related neurodegeneration, and it is regulated by cytochromes P450 (CYPs), such as CYP1A2; these are responsible for the oxidative metabolism of both exogenous and endogenous substrates in the brain, subsequently impacting ALS. The function

  • Nystagmus in Ramsay Hunt syndrome with or without dizziness
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-26
    Jiyeon Lee, BoYoon Choi, Haemin Noh, Hamin Jeong, Jung Eun Shin, Chang-Hee Kim

    Background The presence of dizziness has been reported as a negative prognostic factor for recovery of facial palsy in Ramsay Hunt syndrome (RHS). The aim of this study was to investigate the incidence and patterns of nystagmus in RHS patients without dizziness, and discuss possible mechanisms. We also compared the severity and prognosis of facial palsy between RHS patients with and without dizziness

  • Social, professional and neuropsychiatric outcomes in patients with myasthenia gravis
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-26
    Bruno Kusznir Vitturi, Alexandre In Han Kim, Lucas Pari Mitre, Ada Pellegrinelli, Berenice Cataldo Oliveira Valerio

    Background Recent medical advances have enabled the control of neurological symptoms and increased survival of patients with myasthenia gravis (MG). However, MG has many veiled consequences that may be underestimated by neurologists. Our aim was to clarify the social, professional, and neuropsychiatric issues of MG patients. Methods We carried out a cross-sectional cohort study with MG patients from

  • Sulthiame add-on treatment in children with epileptic encephalopathy with status epilepticus: an efficacy analysis in etiologic subgroups
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-26
    Seda Kanmaz, Erdem Simsek, Hepsen Mine Serin, Sanem Yilmaz, Gul Aktan, Hasan Tekgul, Sarenur Gokben

    Purpose Sulthiame (STM) has been recommended as an effective antiepileptic drug (AED) in children with epileptic encephalopathy with status epilepticus in sleep (ESES). The aim of this study is to evaluate the efficacy of STM add-on treatment in children with pattern of ESES with respect to the etiologic subgroup. Methods Twenty-nine children with ESES pattern with three different etiologic subgroups

  • Electroencephalography at the time of Covid-19 pandemic in Italy
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-26
    Giovanni Assenza, Jacopo Lanzone, Lorenzo Ricci, Marilisa Boscarino, Mario Tombini, Carlo Andrea Galimberti, Lara Alvisi, Laura Tassi, Lidia Broglia, Vincenzo Di Lazzaro, Oriano Mecarelli

    Objective During the Covid-19 pandemic, government restrictions limited health care to urgent needs. Neurophysiology centers had to suddenly reschedule their activities, with a lack of specific recommendations about electroencephalography (EEG) execution. During the pandemic phase 1, we launched an online survey to understand the flaws and strengths of the EEG management in Italy at the time of Covid-19

  • A prospective clinical study of detailed neurological manifestations in patients with COVID-19
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-25
    Ömer Karadaş, Bilgin Öztürk, Ali Rıza Sonkaya

    Background COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological findings via obtained face-to-face anamnesis and detailed neurological examination in patients with

  • COVID-19-related strokes in adults below 55 years of age: a case series
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-24
    Farzad Ashrafi, Alireza Zali, Davood Ommi, Mehri Salari, Alireza Fatemi, Mehran Arab-Ahmadi, Behdad Behnam, Arash Azhideh, Mohammad Vahidi, Maryam Yousefi-Asl, Reza Jalili khoshnood, Soroor Advani

    Background Coronavirus infection is a novel respiratory disease affecting people across the world. Although the majority of patients present with fever, dyspnea, cough, or myalgia, various signs and symptoms have been reported for this disease. Recently, neurological symptoms have been noticed in patients with COVID-19 with unknown etiology. However, the occurrence of strokes in young and middle aged

  • The impact of cigarette smoking in predicting stroke using CHADS2 and CHA2DS2-VASc schemas.
    Neurol. Sci. (IF 2.415) Pub Date : 2020-06-22
    Ming-Liang Zuo,Chun-Mei Li,Yan Deng,Sanjib Bhattacharyya,Ping Shuai,Hung-Fat Tse,Chung-Wah Siu,Li-Xue Yin

    Objective To determine the impact of smoking status in the prediction of stroke using CHADS2 and CHA2DS2-VASc schemes. Methods Five hundred twenty-eight consecutive patients with arrhythmic symptoms and without any documented arrhythmia from Queen Mary Hospital, Hong Kong, were followed up to determine the incidence of ischemic stroke, new-onset atrial fibrillation (AF), or all-cause mortality. Smoking

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