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Changes in the Levels of Neurospecific Proteins and Indices of Apoptosis in the Rat Cornea at Chronic Ethanol Consumption: Protective Effects of Thiamine Administration Neurophysiology (IF 0.5) Pub Date : 2023-10-20 O. S. Pavlova, V. L. Bilous, V. V. Korsa, S. P. Stepanenko, Yu. M. Parkhomenko, A. O. Tykhomyrov
Long-term ethanol (EtOH) consumption may induce damage to corneal nerves leading to the development of ocular diseases, vision impairments, and possible blindness. We investigated levels of neurospecific proteins and apoptotic regulators in the cornea of rats chronically exposed to ethyl alcohol and also effects of high-dose thiamine (vitamin B1) administration on these indices. Albino male rats consumed
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Augmented Reality in Sports Education and Training for Children with an Autism Spectrum Disorder Neurophysiology (IF 0.5) Pub Date : 2023-10-20 A. Fridhi, N. Bali
3D modeling and augmented reality (AR) offer innovative perspectives for training in sports activity for children with autism spectrum disorders (ASDs). The objective of this review article is to offer a reflection on the design and learning methodology in the field of adapted physical activities, with the aim of improving its credibility toward children with ASDs. We also present an original experience
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Comparison of Various Empirical-Mode Decomposition Techniques of EEG for the Diagnostics of Epilepsy Neurophysiology (IF 0.5) Pub Date : 2023-10-20 B. Gopika, J. E. Jacob
One of the most prevalent neurological conditions of the human brain, epilepsy, can be identified mostly with electroencephalogram (EEG) signals. Complex and non-stationary brain signals captured by EEG recordings can be used to identify epileptic episodes. Our study is aimed at constructing a model for epilepsy diagnostics based on the characteristics of decomposed EEG signals. Several features from
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High Expression of LncRNA XIST as an Index Helping to Diagnose Parkinson’s Disease Neurophysiology (IF 0.5) Pub Date : 2023-10-20 L. Zhang, G. Li, D. Lu, Q. Dai
LncRNA XIST plays roles in the development of such degenerative disorder as Parkinson’s disease (PD). We herein explored its diagnostic value. Clinical baseline data (age, sex, BMI, years of education, and PD family history) of PD patients and healthy controls, as well as the diseases course in PD patients, were recorded. The PD patients were staged using the Hoehn and Yahr grading scale. Case severity
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Simulation of Store-Operated Calcium Entry in Neurons Neurophysiology (IF 0.5) Pub Date : 2023-10-20 E.È. Saftenku
Store-operated calcium entry (SOCE) is a unique Ca2+ entry pathway that is specifically activated by the depletion of Ca2+ from the endoplasmic reticulum (ER). This process is ubiquitous in non-excitable cells; in contrast, the role of SOCE in neurons is still poorly understood because of the complexity of Ca2+ influx mechanisms existing in these cells. However, growing evidence indicates that SOCE
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Synergic Effect of Isometric Resistance Training and Subthreshold Electrical Neuromuscular Stimulation on the Excitability of Spinal Motoneurons in Humans Neurophysiology (IF 0.5) Pub Date : 2023-10-20 K. Takeda, S. Koyama, K. Ushiroyama, Y. Naoi, Y. Saito, H. Sakurai, Y. Kanada, S. Tanabe
The rate of force development (RFD) has been widely used as an indicator of muscle strength in the clinical practice. Our previous study showed that the RFD within short time intervals could be increased by low-load isometric resistance training (IRT) with sub-motor threshold electrical neuromuscular stimulation (SMT ENMS) compared with the low-load IRT alone. However, the effect of the combined method
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Modes of Operation of the Endoplasmic Reticulum Ca2+ Transport Systems in Neurons: Insights from the Compartmental Models Neurophysiology (IF 0.5) Pub Date : 2023-10-18 E.È. Saftenku
In neurons, the endoplasmic reticulum (ER) modulates elevations of the cytosolic free Ca2+ concentration ([Ca2+] ) in response to extracellular stimulation by accumulating Ca2+ via the sarcoplasmic/endoplasmic reticulum Ca2+-ATPases (SERCAs) or by releasing Ca2+ via the ER Ca2+ channels. SERCA inhibitors are often used as a tool for investigating the contribution from ER Ca2+ transport to the [Ca2+]
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Facial Emotion Recognition, Misattribution, and Response Time in Schizophrenia and Bipolar Disorder Neurophysiology (IF 0.5) Pub Date : 2022-02-25 C. Priyesh, C. A. Suryavanshi, A. Sasidharan, R. Bhandary, R. V. Behere, K. R. Nayak
Social cognition abilities are significantly impaired in serious mental illnesses. Facial emotion recognition deficits (FERD) have been consistently reported in schizophrenia (SCZ), while the respective findings in bipolar disorder (BPD) are mixed. Assessment of FERD using a task that imposes a time restriction on the stimulus presentation and response may be more akin to real-life situations. We examined
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Effects of Physical Training in Different Modes on Cognitive Function and GNDF Level in Old Mice Neurophysiology (IF 0.5) Pub Date : 2022-02-25 S. Sarvat, A. Sabaghi, N. Yosofvand, B. Ebrahimi
We compared the effects of physical high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the cognitive functions in old mice and on serum levels of glial cell line-derived neurotrophic factor (GDNF) in these animals. Thirty old (aged 22 months) mice were divided into control (no training), MICT, and HIIT groups; the training protocol (treadmill running) was applied
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Binary Particle Swarm Optimization-Based Feature Selection for Predicting the Class of the Knee Angle from EMG Signals in Lower Limb Movements Neurophysiology (IF 0.5) Pub Date : 2022-02-25 I. S. Dhindsa, R. Gupta, R. Agarwal
The performance of a binary particle swarm optimization-based feature selection (BPSOFS) for predicting the class of the knee angle (KA) from myoelectric signals in lower limb movements was examined. Surface EMG (sEMG) signals were recorded from the vastus lateralis and biceps femoris muscles while performing a task of standing up from and sitting down on the chair. The knee angle was measured using
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Castration Eliminates the Impairment Effects of Nandrolone on Passive Avoidance Learning of Adolescent Male Rats Neurophysiology (IF 0.5) Pub Date : 2022-02-25 F. Moradpour, Z. Salimi, F. Zarei, A. Pourmotabbed, S. E. Nedaei, M. Veisi
In recent years, the misuse of nandrolone decanoate (ND) among non-athletes, especially adolescent males, has become a growing problem due to the adverse effects of this drug. In our previous study, we have shown that pre-training administration of a high ND dose (100 μg/2.5μl) impairs the acquisition of passive avoidance learning (PAL), but the underlying mechanism has not been clearly evaluated.
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Effects of Citicoline on Structural/Functional Consequences of Focal Ischemia of the Rat Brain Neurophysiology (IF 0.5) Pub Date : 2022-02-25 O. P. Mankivska, N. V. Chaika, G. G. Skibo
Effects of citicoline on the volume of ischemically damaged cerebral tissue, dynamics of neurological deficiency, and indices of neurobehavioral tests were examined in rats with experimental transient focal cerebral ischemia induced by 60-min-long occlusion of the middle cerebral artery (MCA). Citicoline was administered immediately after beginning of reperfusion, and introductions were repeated for
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Effects of a Combination of Transcranial DC Cerebellar Stimulation and Pioglitazone Administration on Pentylenetetrazole-Induced Seizures in Kindled Rats Neurophysiology (IF 0.5) Pub Date : 2022-02-25 L. S. Godlevsky, O. B. Poshyvak, M. P. Pervak, K. A. Latypov, K. O. Prybolovets, O. S. Yehorenko
In rats with the kindling syndrome induced by i.p. injections of pentylenetetrazole (PTZ; 35 mg/kg daily, for three weeks), the averaged latency of seizures induced by a test injection of PTZ (35 mg/kg) was significantly greater (by 42.2%, P < 0.05 vs. control) after a combination of pioglitazone administration (100 mg/kg, i.p.) and transcranial DC stimulation (tDCS, 300 μA, 10 min, cathode on the
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Behavior of Rats in the Open Field within the Early Period after Light-Degree Blast-Induced Neurotrauma Neurophysiology (IF 0.5) Pub Date : 2022-02-25 Yu. V. Kozlova
Blast-induced neurotrauma (BINT) is a specific type of traumatic brain injury (TBI). At present, this type of injury is rather widespread throughout the world due to its occurrence in military conflicts and terrorism acts. Consequences of such traumas form an important social and medical problem. Brain injuries in the case of BINT result mostly from a specific action of the main pathological factor
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Expression of Cytoskeletal Proteins in Neurons of the Rat Sensorimotor Cortex upon Hypoperfusion of the Brain and Sensitization by Cerebral Antigen Neurophysiology (IF 0.5) Pub Date : 2022-02-25 L. M. Yaremenko, A. N. Grabovoy, S. E. Shepelev
Relatively mild disturbances in the blood supply of the rat brain provided by ligation of one common carotid artery leading to relatively mild disturbances of the cerebral blood supply or sensitization of the animals by brain antigen induce noticeable disorganization of the cytoskeleton in neurons of the sensorimotor cortex (SMC). The most considerable shifts in the system of cytoskeleton proteins
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Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease Neurophysiology (IF 0.5) Pub Date : 2021-12-02 Danielyan, M. H., Кarapetyan, K. V., Nebogova, K. A., Nazaryan, O. H., Khachatryan, V. P.
Morphofunctional characteristics of the substantia nigra (SN) were compared in four groups of experimental rats: (i) control (sham-operated), (ii) animals with a rotenone model of Parkinson’s disease, PD (induced by stereotaxic unilateral microinjections of 12 μg into the median forebrain bundle), (iii) rats with modeled PD treated with i.m. injections of 100 μg/kg galarmin, and (iv) similar rats but
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Intrahippocampal Injections of Ghrelin and Aerobic Physical Exercise: Effects on Learning and Passive Avoidance Memory in Rats Neurophysiology (IF 0.5) Pub Date : 2021-11-30 Farzin, M., Babaei, P., Rostampour, M.
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptors, plays a considerable role in important neurological effects related to food intake and energy homeostasis. As was found, regular physical activity may provide significant improvement of the cognitive functions in various behavioral situations. We aimed to evaluate the effects of ghrelin and physical training (aerobic exercises)
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Regulatory Effects of Stevia Rebaudiana on NADPH Oxidase-Related Manifestations of Oxidative Stress in Diabetic Rats with Spinal Cord Injury Neurophysiology (IF 0.5) Pub Date : 2021-11-30 Simonyan, K. V., Chavushyan, V. A., Avetisyan, L. G., Simonyan, R. M., Isoyan, A. S., Simonyan, G. M., Hovhannisyan, L. E., Simonyan, M. A.
For the first time, a method for isolation and purification of Nox isoforms (Nox1+Nox2), as well as of O2–-producing stable associates of Nox and lipoprotein-containing NADPH isoforms (NCL associates), from the membranes of cells and intracellular formations of the spinal cord (SC) and bone marrow (BM) of albino rats was developed, and the respective estimates were obtained. The effects of treatment
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Effects of Acute Ethanol Intoxication on Local Field Potentials in the Rat Lateral Septum Neurophysiology (IF 0.5) Pub Date : 2021-11-30 Chaikovska, O. V., Rokunets, I. L., Dovhan, O. V., Vlasenko, O. V.
The lateral septum (LS) is an important part of the limbic and reward brain systems; its activity has been associated with the development of different aspects of addiction. Using a stereotaxically inserted semi-microelectrode, we recorded local field potentials (LFPs) from the rat LS under background conditions and after i.p. injection of 2.0 g/kg body mass 15% ethanol (Ethl) solution. The recorded
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Analgesic Action of Invasive Carboxytherapy: Mechanisms and Applications Neurophysiology (IF 0.5) Pub Date : 2021-11-30 Seredynska, N. M., Drogovoz, S. M., Shchokina, E. G., Ivantsyk, L. B., Stoletov, Yu. V., Shtroblya, A. L., Kireyev, I. V.
At present, pharmacotherapy (mostly applications of narcotic and non-narcotic analgesics and nonsteroidal anti-inflammatory drugs) is the main approach in fighting pain. Techniques of reflexotherapy (including acupuncture), which belong to the so-called alternative medicine and are largely based on empirical approaches, attract at present increasing attention and are beginning to be applied in “official”
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Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) Neurophysiology (IF 0.5) Pub Date : 2021-11-30 Mekhtiev, A. A., Ismailova, U. S.
We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test
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Serum Levels of the Biomarkers Associated with Astrocytosis, Neurodegeneration, and Demyelination: Neurological Benefits of Citicoline Treatment of Patients with Ischemic Stroke and Atrial Fibrillation Neurophysiology (IF 0.5) Pub Date : 2021-11-30 Kuryata, O. V., Kushnir, Yu. S., Nedzvetsky, V. S., Korsa, V. V., Tykhomyrov, A. A.
Ischemic stroke is a main complication of atrial fibrillation (cardiac arrhythmia). The aim of our study was to estimate the effects of citicoline (CDP-choline) therapy on the levels of circulating neurospecific protein markers in serum of the patients with ischemic stroke and atrial fibrillation. Fiftyfour patients (mean age 76 years) treated with citicoline in a dose of 2.0 g daily intravenously
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Effects of a Diet Supplemented with Fruit Antioxidants (Mango) on the Expression of Kir6.2 (KCNJ11) in the Hippocampus and Kidney of Diabetic Rats Neurophysiology (IF 0.5) Pub Date : 2021-08-16 Romo-Robles, D. P., Domínguez-Avila, J. A., Montiel-Herrera, M., Ayala-Zavala, J. F., Astiazaran-Garcia, H., González-Aguilar, G. A.
Diabetes induces inflammation in the brain and kidneys; it is also known to be linked with changes in the expression and functionality of Kir channels. Diets rich in antioxidants (e.g., phenolic compounds) tend to reduce diabetes-related oxidative damage in several organs and the expression of K+ channels. We evaluated the effect of a diet supplemented with mango cv. ‘Ataulfo’ pulp and peel on the
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Constitutive Neurogenesis in the Brain of Different Vertebrate Groups Neurophysiology (IF 0.5) Pub Date : 2021-08-13 Stukaneva, M. E., Pushchina, E. V.
This review discusses the similarities and differences in the processes of constitutive (“adult”) neurogenesis, which have arisen in the course of evolution in higher and lower vertebrates. The data on the features of the regenerative potential in various animal species manifested under conditions of damage to the CNS and the possibilities for restoration due to the regeneration capabilities are analyzed
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NADPH Oxidase and Superoxide-Producing Associates in Cells of the Spinal Cord and Bone Marrow in Diabetic Rats with Spinal Cord Injury Neurophysiology (IF 0.5) Pub Date : 2021-08-12 Simonyan, K. V., Chavushyan, V. A., Lorikyan, A. G., Simonyan, R. M., Avetisyan, L. G., Isoyan, A. S., Simonyan, G. M., Simonyan, M. A.
For the first time, a method for isolation and purification of the total fraction of NOX isoforms (NOX1 + NOX2) and the total fraction of O2 – producing stable associates of NOX and NADPH isoformscontaining lipoprotein (NCL associate) from the membranes of cells and intracellular formations of the spinal cord (SC) and bone marrow (BM) was developed in a rat model of fructose-induced diabetes. Characteristic
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Roles of Ca2+, Mg2+, and Ba2+ Cations in the Regulation of TRPV1 Channels in Rat DRG Neurons Neurophysiology (IF 0.5) Pub Date : 2021-08-12 Petrushenko, M. O., Petrushenko, E. A., Lukyanetz, E.A.
In experiments performed on a primary culture of neurons isolated from the dorsal root ganglia (DRGs) of rats, we estimated the level of intracellular calcium using fluorescence microscopy and a fluorescent probe for divalent cations, Fura 2. It was found that capsaicin (Caps) affects the Ca2+ permeability of the plasmalemma and does not cause Ca2+ release from the intracellular stores. As [Ca2+]in
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Neuropsychological and Psychosocial Consequences of the COVID-19 Pandemic Neurophysiology (IF 0.5) Pub Date : 2021-08-12 Namdar, P., Mojabi, N. A., Mojabi, B.
The coronavirus disease designated as COVID-19 reached the level of a pandemic, affecting countries all across the world. Widespread outbreaks of COVID-19 are associated with psychological distress and symptoms of mental disorders. This article is a narrative review of the existing scientific literature on mental health of the society and interventions relevant to the COVID-19 pandemic. A search in
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Glutamate Excitotoxicity; a Possible Mechanism for Apoptosis of Motoneurons in Adult Mouse Spinal Cord Slices Neurophysiology (IF 0.5) Pub Date : 2021-08-12 Momeni, H. R., Jarahzadeh, M., Farjad, E.
In experiments on mice spinal cord slices, it was found that intense apoptosis of motoneurons develops in these slices rather rapidly (6 hours). This process can be significantly suppressed by treatment with the NMDA glutamate receptor antagonist MK-801 (50 μM) and AMPA/kainite non-NMDA glutamate receptor antagonist CNQX (100 μM). Such treatment considerably increased the percentage of viable motoneurons
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Effects of a One-Time Biofeedback EMG Session on Neuromuscular Activity of the Pelvic Floor Muscles in Pregnant Women Neurophysiology (IF 0.5) Pub Date : 2021-08-12 Błudnicka, M., Piernicka, M., Kortas, J., Biernacka, B. Duda, Szumilewicz, A.
In 92 healthy nulliparous women with uncomplicated pregnancies, the function of the pelvic floor muscles (PFMs) was assessed by surface electromyography (EMG) with the use of vaginal probes. The impact of a single biofeedback session on EMG parameters was examined. As was found, such sessions provided significant increases in the EMG amplitude in 60- and 10-sec-long contractions (P = 0.01 and P = 0
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Effects of Modeling of Hypercalcemia and β-Amyloid on Cultured Hippocampal Neurons of Rats Neurophysiology (IF 0.5) Pub Date : 2021-05-05 N. M. Rozumna, V. M. Shkryl, V. V. Ganzha, E. A. Lukyanetz
Alzheimer’s disease (AD) is the most common type of dementia; it is characterized by accumulations of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Intracellular Ca2+ homeostasis plays an important role in the control of events in the neuronal system, including neurotransmitter release, synaptic plasticity, memory, and neuronal death. Therefore, dysregulation of Ca2+ neuronal homeostasis
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Temperament of the Individual and Peculiarities of EEGs in Patients Suffering from Neurological Spinal Disorder-Induced Neck and Back Pain Neurophysiology (IF 0.5) Pub Date : 2021-05-04 I. A. Nazarchuk, L. P. Zabrodina, S. V. Fedosieiev
Forty-seven patients suffering from neck and/or back pain were examined; their temperament was evaluated using the Eysenck Personality Questionnaire (EPQ); the pain syndromes in these subjects were described according to the visual analogous scale (VAS). All patients were subjected to the detailed EEG examination. As was found, characteristics of pain in subjects of the examined group noticeably depended
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Adverse Modulation of the Firing Patterns of Cold Receptors by Volatile Anesthetics Affecting Activation of TRPM8 Channels: a Modeling Study Neurophysiology (IF 0.5) Pub Date : 2021-05-04 S. M. Korogod, N. V. Maksymchuk, L. E. Demianenko, O. O. Vlasov, G. S. Cymbalyuk
Transient receptor potential melastatin 8 channels (TRPM8s) are molecular sensors of temperature. They are expressed in primary afferent neurons (PANs) and function as receptors of innocuous cold. Depolarization of sensory endings of PANs by cooling-induced TRPM8 current is transduced into patterns of action potentials, encoding information about temperature and conveying it to the CNS, where an adequate
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A New Approach to the Study of Two-Joint Upper Limb Movements in Humans: Independent Programming of the Positioning and Force Neurophysiology (IF 0.5) Pub Date : 2021-05-04 M. Zasada, A. V. Gorkovenko, S. S. Strafun, D. A. Vasylenko, W. Pilewska, Yu. A. Kulyk, A. I. Kostyukov
A new approach to mechanostimulation of the human forelimbs is proposed for studying various problems of motor control. The prototype of the device is based on a modern computerized control system for the planar two-dimensional transitions of the working organ, which includes a deformable element and the strain gauge elements; this allows one to register the force vector of the forelimb. In addition
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Cortico-Spinal Neural Interface to Restore Hindlimb Movements in Spinally-Injured Rabbits Neurophysiology (IF 0.5) Pub Date : 2021-05-04 M. A. Younessi Heravi, K. Maghooli, F. Nowshirvan Rahatabad, R. Rezaee
This study aimed to design a neural interface that extracts motor commands from the cerebral cortex and generates fuzzy-based intraspinal stimulations to restore the hindlimb movements. The study consisted of four steps: (i) recording of electrocorticographic (ECoG) signals and of the corresponding leg movements in healthy rabbits, (ii) partial laminectomy to induce spinal cord injury (SCI) and to
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Types of Higher Nervous Activity in Pigs: Characteristics of Behavior and Effects of Technological Stress Neurophysiology (IF 0.5) Pub Date : 2021-05-04 O. V. Danchuk, M. M. Broshkov, V. I. Karpovsky, O. M. Bobrytska, M. I. Tsvivlikhovsky, V. A. Tomchuk, V. O. Trokoz, I. I. Kovalchuk
The strength, balance, and mobility of central nervous processes, which determine behavior, were estimated in six-month-old pigs of the Large White breed. According to the proposed technique, tests with observation of the animal’s reactions to the care stuff, specificities of behavior in the course of feeding, responses to the unexpected sensory stimuli, and peculiarities of the formation of conditioned
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Sexual Behavior, Profile of Steroid Hormones, and Morphology of the Medial Preoptic Nuclei in F1 Male Rat Progeny Prenatally Exposed to Low-Dose Bisphenol A Neurophysiology (IF 0.5) Pub Date : 2021-05-04 A. G. Reznikov, O. V. Sachynska, A. A. Lymareva, L. I. Polyakova
Long-term effects of maternal treatment of Wistar rats with low doses of bisphenol A (BPA) on sexual behaviors, morphology of the medial preoptic nuclei (MPNs) of the hypothalamus, and blood plasma levels of steroid hormones in adult male offspring (first generation) were studied. Bisphenol was introduced by gavage within the last week of gestation at a daily dose of 25 μg/kg body mass. Estradiol-17β
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Effects of the Involvement of Calcium Channels on Neuronal Hyperexcitability Related to Alzheimer’s Disease: A Computational Model Neurophysiology (IF 0.5) Pub Date : 2021-05-04 J. Garg, A. Lakhani, V. Dave
Signaling pathways of neurons depend on such factors as the type and “strength” of the synapse, cable properties, distribution of ion channels, and biophysical parameters involved. Aggregation of amyloidbeta (Aβ) in Alzheimer’s disease (AD) dramatically affects the functioning of neurons (hippocampal CA1 pyramidal neurons in particular) in multiple ways, which results in loss of memory and cognitive
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Hydrogen Sulfide and Pathophysiology of the CNS Neurophysiology (IF 0.5) Pub Date : 2021-03-03 E. V. Pushchina, K. S. Marinina, S. D. Myasoyedov
The literature data and results of our research team concerning the physiological and pathological effects of hydrogen sulfide, a gas transmitter that has recently attracted significant and increasing attention of neurophysiologists, are analyzed. Hydrogen sulfide is a gaseous signaling molecule, the effects of which were discovered later than those of NO and CO; H2S was found to play great pathophysiological
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Analgesic Effects of Constant and Frequency-Modulated LED-Generated Red Polarized Light Neurophysiology (IF 0.5) Pub Date : 2021-03-02 S. A. Gulyar, Z. A. Tamarova
We compared the analgesic effects of continuous and frequency-modulated red and infrared LEDproduced polarized light (PL) measured in a formalin test model. The control group consisted of 20 albino mice, while the six experimental groups included 10 animals each. Red LED PL (637 nm) was found to be more effective in suppressing pain than infrared light (860 nm); when PL was applied to the locus of
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Fast Blocking Effect of Gallamine on LCC Channels: Analysis Using a Truncated Kinetic Scheme Neurophysiology (IF 0.5) Pub Date : 2021-03-02 O. V. Lunko, O. O. Lunko
Modulation of Large-conductance cationic (LCC) channel currents through the inner nuclear membrane of rat Purkinje neurons by gallamine was estimated using analysis of the amplitude histograms. A kinetic scheme consisting of one open state and one blocked state of the channel was used. The search for optimal kinetic parameters of the truncated model was performed for the analysis of the blocking effect
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Post-Concussion Syndrome after a Mine Blast Injury: Neuropsychological Consequences and Changes of the Cognitive Evoked Potentials (P 300) Neurophysiology (IF 0.5) Pub Date : 2021-03-01 L. L. Chebotariova, A. I. Tretiakova, A. S. Solonovych, L. M. Sulii, A. Yu. Zol’nikova
In 115 male patients with the post-concussion syndrome (PCS) after a mine blast injury (MBI) and 30 control healthy subjects, complex clinical and instrumental diagnostics were performed. The age of the patients varied from 18 to 45 years, the post-traumatic MBI interval was 0.5 to 3 years, and the MBIs were accompanied by an acoustic (AT) or combined acoustic/barotrauma in 92% of the cases. The standard
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Activation and Desensitization of TRPV1 Channels under the Influence of Capsaicin Neurophysiology (IF 0.5) Pub Date : 2021-03-01 M. O. Petrushenko, E. A. Petrushenko, E. A. Lukyanetz
The work was carried out on primary cultures of neurons (1- to 2-day-long cultivation) isolated from DRGs of 8- to 12-day-old rats; fluorescent microscopy was used for evaluation of the level of intracellular calcium in the studied units. Small-sized neurons supposedly attributable to nociceptors (diameter 21–37 μm and mean surface area 589 ± 96 μm2) were selected. Capsaicin (100 nM) was applied for
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Acoustic Myography as a Noninvasive Technique for Assessing Muscle Function: Historical Aspects and Possibilities for Application in Clinical Practice Neurophysiology (IF 0.5) Pub Date : 2021-03-01 M. B. Shcherbynina, V. M. Gladun, V.M. Sarana
Acoustic myography is a technique for detecting and measuring mechanical oscillations of a sound/infrasound-range frequency produced during muscle contractions; such oscillations can be recorded using special microphones. We described the history of formation of the so-called acoustic myography (AMG) and modern concepts on recording the respective phenomena. Fundamental features of these biological
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Heart Rate Variability in 12- to 13-Year-Old Adolescents Neurophysiology (IF 0.5) Pub Date : 2021-03-01 A. M. Sitovskyi, O. V. Radchenko, V. S. Dmytruk, O. Y. Andriichuk, O. B. Roda, I. V. Savchuk
Estimation of age and gender peculiarities of heart rate variability (HRV) in adolescents will help researchers to predict the potential abilities of the adaptation mechanisms, to evaluate the risk of cardiovascular diseases, and to select the dosage of physical activity in sporting and rehabilitation in this population. The respective data may improve our understanding of the age and sex characteristics
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Effects of 2.1 GHz Electromagnetic Radiation on Locomotor Activity, Recognition Memory, and Anxiety-Related Behavior in Rats Neurophysiology (IF 0.5) Pub Date : 2021-03-01 Ç. Gökçek-Saraç
The effects of short-term (2 h per day for 7 days) exposures to different doses of 2.1 GHz radiofrequency electromagnetic radiation (RF-EMR) on cognition and behavior of rats were examined. The animals were divided into three equal groups, sham-exposed group 1 and two RF groups irradiated with different doses, groups 2 and 3, respectively. To assess locomotor activity, recognition memory, and anxiety-related
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Geospatial Virtual/Augmented Environment: Applications for Children with Pervasive Developmental Disorders Neurophysiology (IF 0.5) Pub Date : 2020-11-29 A. Fridhi, N. Bali, N. Rebai, R. Kouki
The aim of this research is to describe applications of virtual/augmented reality (VR/AR) to the problems of children with pervasive developmental disorders (PDDs). We will try to verify whether the use of these techniques makes interventions in the case of children with PDDs (concerning their learning and communicative abilities and the state of their emotional sphere) expedient or not. This paper
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Motor Commands for Planar Movements of the Upper Limb: Modeling with Taking into Account Realistic Osteo-Muscular Relations Neurophysiology (IF 0.5) Pub Date : 2020-11-29 A. V. Gorkovenko, S. S. Strafun, Yu. A. Kulyk, W. Pilewska, M. Zasada, A. I. Kostyukov
Studies of motor control in humans require the formation of adequate concepts about the structure and metric characteristics of the musculoskeletal system, which provides the performance of the respective movements; such representations, in turn, are necessary prerequisites for further modeling of the phenomenology of motor control, theoretical analysis of the relevant processes, and interpretation
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Brain Network Connectivity and the Choice Motor Reaction in Combatants with Mild Traumatic Brain Injuries Neurophysiology (IF 0.5) Pub Date : 2020-11-29 N. B. Filimonova, M. Yu. Makarchuk, I. G. Zyma, V. V. Kal’nysh, A. F. Cheburkova
We examined times (latencies) of two types of the sensorimotor (visuomotor) reactions, simple sensorimotor reaction (SSMR) and choice motor reaction (ChMR), in men (combatants) suffering from the consequences of mild traumatic brain injury (mTBI) during the Joint Forces Operation in the East of Ukraine (17 right-handed volunteers aged 27–43 years) and compared the respective values with those demonstrated
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Ganglion-Specific Sensitivity of P2X3 Receptors to Leu-Enkephalin Neurophysiology (IF 0.5) Pub Date : 2020-11-29 V. B. Kulyk, I. V. Chizhmakov, O. V. Iegorova, T. M. Volkova, G. I. Kharytonenko, O. O. Drozd, O. A. Krishtal
In this study, several properties of modulation of P2X3 currents by an endogenous opioid, leu-enkephalin (LEK), in neurons of the dorsal root and nodose ganglia (DRGs and NGs, respectively) were compared. P2X3-mediated currents were recorded using a patch-clamp technique in the whole-cell configuration. P2X3 receptors in DRG neurons were found to be more sensitive to LEK application compared to NG
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Autonomic Dysfunction in Postmenopausal Women with the Carpal Tunnel Syndrome Neurophysiology (IF 0.5) Pub Date : 2020-11-29 B. Cevik, S. Kurt, O. Sumbul, D. Aksoy
Women frequently experience rather severe autonomic symptoms during the postmenopausal period. The carpal tunnel syndrome (CTS) is also known to be accompanied by certain autonomic symptoms. We aimed to evaluate some autonomic functions in postmenopausal women suffering from CTS. In this case-control study, we performed median nerve conduction and sympathetic skin response (SSR) tests. All patients
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Correction to: Cortico-Spinal Neural Interface to Restore Hindlimb Movements in Spinally-Injured Rabbits Neurophysiology (IF 0.5) Pub Date : 2020-11-01 M. A. Younessi Heravi,K. Maghooli,F. Nowshiravan Rahatabad,R. Rezaee
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Electron Microscopy Analysis of Sciatic Nerve Fibers in C57BL/6 Transgenic Mice Neurophysiology (IF 0.5) Pub Date : 2020-10-09 I. O. Govbakh, O. M. Tsupykov, E. G. Smozhanik, V. V. Rubtsov, M. Tymchyshin, S. A. Kravchenko, D. A. Vasylenko
Hereditary Charcot–Marie–Tooth (CMT) motor/sensory neuropathy is a known disease in the group of polyneuropathies. It is characterized, in particular, by the process of demyelination of peripheral nerve fibers. Various in vivo and in vitro models have been used for elucidation of the mechanisms involved in the demyelination processes. We investigated ultrastructural manifestations of peripheral demyelination
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Regulation and Ethics of Transcranial Electrical Stimulation: A General View Neurophysiology (IF 0.5) Pub Date : 2020-05-01 A. Molero-Chamizo, M. Á. S. Sánchez, R. M. Riquel, C. Gutiérrez Lérida, G. N. Rivera-Urbina
Transcranial application of low-intensity electrical stimuli is a non-invasive brain stimulation procedure, which allows one to alter the excitability of cortical cells in both humans and animals. There is a broad consensus regarding the safety of this approach in humans, and different versions and protocols of this technique have been used in basic research and clinical studies for years. In this
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Partial Inhibition of Na+/K+-ATPase and Plasma Membrane Ca2+-ATPase from the Rat Cerebral Cortex by S-Nitrosoglutathione Neurophysiology (IF 0.5) Pub Date : 2020-05-01 V. N. Tsyvkin, I. M. Prudnikov, A. N. Smirnov, I. V. Pristash
S-nitrosoglutathione (GSNO) is an endogenous S-nitrosylated glutathione derivative (GSH) involved in NO signaling. GSNO acts as a carrier of nitrosyl groups to cysteine (both free amino acid and its residues in proteins), a glutathionylation agent, and an NO donor. We investigated the effects of GSNO, GSH, and oxidized glutathione (GSSG) on the activity of two main ion pumps of the plasma membrane
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Diagnostic Value of the F-wave in Loss of Cervical Lordosis Neurophysiology (IF 0.5) Pub Date : 2020-05-01 G. Y. Neşe, E. Yasemin
We investigated peculiarities of the F waves elicited by stimulation of the median and ulnar nerves in 76 subjects having pronounced loss of cervical lordosis (LCL) and 42 control subjects. The CL angles in these two groups were 0–30 and 31–40 deg, respectively. As was found, the averaged minimum, maximum, and mean latencies and chronodispersion values of both median and ulnar F waves in most cases
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A Wireless Sensorized Insole Design for Spatio-Temporal Gait Analysis Neurophysiology (IF 0.5) Pub Date : 2020-05-01 R. Agarwal, A. Aggarwal, R. Gupta
Gait disorders significantly affect the quality of life and limit individual freedom of the subjects affected. Our knowledge of the spatio-temporal gait parameters provides great insight into the musculoskeletal biology, especially into the foot pathology during gait. The aim of our study was to develop a wireless insole system for both feet and to quantify the gait parameters along with the center
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Excitability Properties of Distal Motor Axons in the Human Ulnar Nerve Neurophysiology (IF 0.5) Pub Date : 2020-03-01 A. G. Kristensen, K. Shibuya, H. Amino, S. Misawa, Y. Sekiguchi, Y. Suzuki, T. Suichi, A. Tsuneyama, K. Nakamura, S. Kuwabara
Excitability properties at the motor point of the abductor digiti minimi (ADM) muscle were measured using an accelerometer placed on the little finger tip in 31 healthy subjects, and the results were compared with those at the wrist level of the ulnar nerve. ADM motor point stimulation allowed us to demonstrate a significantly shorter strength-duration time constant and smaller threshold changes in
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Etiological Aspects for the Occurrence of Diabetic Neuropathy and the Suggested Measures Neurophysiology (IF 0.5) Pub Date : 2020-03-01 M. Grover, R. Makkar, A. Sehgal, S. K. Seth, J. Gupta, T. Behl
Diabetic neuropathy is a painful devitalizing complication of diabetes affecting almost 20% individuals with this disease. Based on the area where neurons are mostly affected, it is categorized into four different types, proximal, peripheral, autonomic, and focal, and each type shows varying symptoms like numbness, gastric problems, heart problems, etc. Sometimes, these symptoms are mistakenly taken
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Characteristics of Autonomic Regulation of the Heart Function in Musicians Playing Wind Instruments Neurophysiology (IF 0.5) Pub Date : 2020-03-01 A. Czyżyk, M. Izak, B. Paleczny
We compared measures of the sympatho-vagal balance in heart regulation and cardiovagal baroreflex sensitivity (BRS) between musicians playing wind instruments ( n = 23) and non-musicians ( n = 19) to elucidate whether playing wind instruments is associated with chronic alterations in autonomic cardiovascular control. The arterial blood pressure was measured and ECG was recorded under resting conditions
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Beneficial Effects of Coconut Oil in Treatment of Parkinson’s Disease Neurophysiology (IF 0.5) Pub Date : 2020-03-01 K. S. Ibrahim, E. M. El-Sayed
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder, characterized by depletion of dopamine resulted from the death of dopaminergic neurons in the substantia nigra . The prevalence and incidence of PD is influenced by several factors, such as age, gender, ethnicity, genetic susceptibilities, and environmental exposures. Coconut oil (Coc) is a rich source of medium-chain triglycerides