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Developmental regulation of zinc homeostasis in differentiating oligodendrocytes Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Christopher M. Elitt, Madeline M. Ross, Jianlin Wang, Christoph J. Fahrni, Paul A. Rosenberg
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Left prefrontal intermittent theta burst stimulation ameliorates tinnitus distress and symptoms of depression – A feasibility study Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 T. Hebel, M. Schecklmann, M.A. Abdelnaim, F.C. Weber, B. Langguth, S. Schoisswohl
Tinnitus remains a notoriously difficult to treat clinical entity. 1–2% of the entire population report relevant emotional distress due to tinnitus, and causal treatments are lacking. Repetitive transcranial magnetic stimulation (rTMS), most commonly of auditory cortical areas, has shown mixed results in the past. Prefrontal rTMS, including intermittent theta burst stimulation (iTBS) has shown more
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Boundary cap neural crest stem cells promote angiogenesis after transplantation to avulsed dorsal roots in mice and induce migration of endothelial cells in 3D printed scaffolds Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N. Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need
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Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Guangzhao Shu, Yang He, Jin Suo, Chunhui Wu, Xudong Gong, Yangyang Xiang, Wenjiao Yang, Jiaxin Cheng, Yu Wang, Weiming Chen, Jingshan Shen
Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been confirmed to induce anxiolytic-like and antipsychotic-like effects. However, the exact mechanisms remain unclear. This study substantiated CBD's interaction with the 5-HT receptor (5-HTR) (CHO cells expressing human 5-HTR) and (rat lower lip retraction test, LLR test). We then assessed the impact of CBD in mice
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EEG correlates of trait test anxiety in the flanker task for adolescents Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Hua Wei, Zhenni Jin
Adolescents face constant exams and often experience severe test anxiety. Previous studies suggested that test anxiety impairs individuals’ inhibitory control. Neurophysiological evidence suggests that anxiety interferes with the recruitment of the prefrontal region of the brain, which modulates top-down attentional control during the completion of inhibitory control tasks. However, there is little
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Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-08 Dilara Altay Ozturk (Öztürk), Yavuz Erden, Suat Tekin
MOTS-c, a mitochondrial-derived peptide, acts as a systemic hormone and MOTS-c level is inversely correlated with markers of obesity. Obesity is a risk factor for male reproductive physiology and is expressed as an important cause of infertility. In this study, we aimed to determine the effects of MOTS-c, which has been proven in the hypothalamus and testicles, on the actors involved in the reproductive
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Glycine transporter-1 inhibition by NFPS promotes neuroprotection against striatal damage models Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-07 Raul Izidoro Ribeiro, Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, Isabel Vieira de Assis Lima, Paula Maria Quaglio Bellozi, Onésia Cristina Oliveira-Lima, Ágatha Oliveira Giacomelli, Alexander Birbrair, Renato Santiago Gomez, Antônio Carlos Pinheiro de Oliveira, Henning Ulrich, Mauro Cunha Xavier Pinto
The striatum, an essential component of the brain's motor and reward systems, plays a pivotal role in a wide array of cognitive processes. Its dysfunction is a hallmark of neurodegenerative diseases like Parkinson's disease (PD) and Huntington's disease (HD), leading to profound motor and cognitive deficits. These conditions are often related to excitotoxicity, primarily due to overactivation of NMDA
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Effects of anxiety state on N400 event-related brain potential response to unexpected semantic stimuli Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-07 Jennifer R. Lepock, Todd Girard, Justice Cupid, Michael Kiang
Emotional states can influence how people use meaningful context to make predictions about what comes next. To measure whether state anxiety influences such prediction, we used the N400 event-related brain potential (ERP) response to semantic stimuli, whose amplitude is smaller (less negative) when the stimulus is more predicted based on preceding context. Participants ( = 28) were randomized to one
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Blockage of metallothionein synthesis via adrenaline β receptor activation invalidates dehydroeffusol-mediated prevention of amyloid β1-42 toxicity Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-02 Haruna Tamano, Mako Takiguchi, Daichi Murakami, Yuya Kawano, Toshiyuki Fukuda, Hiroki Ikeda, Yasuhito Akagi, Shinji Ikeura, Atsushi Takeda
Dehydroeffusol, a major phenanthrene in , protects neurodegeneration induced by intracellular Zn ferried by extracellular amyloid β (Aβ). Here we focused on adrenaline β receptor activation and the induction of metallothioneins (MTs), intracellular Zn-binding proteins to test the protective mechanism of dehydroeffusol. Isoproterenol, an agonist of adrenergic β receptors elevated the level of MTs in
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Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-01 Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji
The gut microbiota is associated with memory; however, the relationship between dysbiosis-induced memory deficits and hippocampal glutamatergic neurons remains unclear. In our study, a mouse dysbiosis model showed impaired memory-related behavior in the passive avoidance test; decreased expression levels of glutaminase, excitatory amino acid transporter (EAAT)1, EAAT2, vesicular glutamate transporter
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Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson’s disease patients from India Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-29 Swagata Sarkar, Arindam Biswas, Sabbir Ansari, Supriyo Choudhury, Rebecca Banerjee, Suparna Chatterjee, Sanjit Dey, Hrishikesh Kumar
Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson’s disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key role of dopamine type 3 (D3) receptor polymorphism (Ser9Gly; rs6280) in LID. Its contribution to development of LID among Indian PD patients has remained relatively
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Chronic mild stress-induced dysregulation of MAPK and PI3K/AKT signaling in the hippocampus and medial prefrontal cortex of WKY female rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-29 Kristina Virijevic, Natasa Spasojevic, Bojana Stefanovic, Harisa Ferizovic, Milica Jankovic, Perica Vasiljevic, Sladjana Dronjak
Wistar-Kyoto (WKY) rats subjected to chronic mild stress (CMS) represent a valid model of treatment-resistant depression (TRD). Considering that depression is more prevalent in women than in men, in the present study, female rats were used. We investigated the effect of CMS on behavior and different factors involved in neuroinflammatory processes and neuroplasticity in the hippocampus and medial prefrontal
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Role of the intracerebroventricular injection of the visfatin and its interaction with neuropeptide Y and nitric systems on food intake in neonatal chicken Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-29 Morteza Hesari, Shahin Hassanpour, Morteza Zendehdel, Bita vazir
Visfatin play an essential role in the central regulation of appetite in birds. This study aimed to determine role of intracerebroventricular (ICV) injection of the visfatin on food intake and its possible interaction with neuropeptide Y (NPY) and nitric oxide system in neonatal broiler chicken. In experiment 1, neonatal chicken received ICV injection visfatin (1, 2 and 4 µg). In experiment 2, chicken
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Thermosensitive hydrogel containing ethosuximide-loaded multivesicular liposomes attenuates age-related hearing loss in C57BL/6J mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-28 Wei Li, Wenfang Sun, Guoming Zhang, Yi Lu, Chunfu Dai
Ethosuximide is the first drug reported to protect against age-related hearing loss, but its benefits are hampered by the pronounced side effects generated through systemic administration. We prepared a thermosensitive hydrogel containing ethosuximide-encapsulated multivesicular liposomes (ethosuximide-loaded MVLs-Gel) and evaluated its functional and histological effects on age-related hearing loss
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“Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients” Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-28 Kazuo Shigematsu, Naoyuki Komori, Mitsuko Ideno, Hisakazu Yamagishi
The antibody drugs targeting β-amyloid in Alzheimer's disease pose risks of inflammation and vascular damage. It is known that neprilysin, an endogenous enzyme responsible for β-amyloid degradation, is reduced in areas with β-amyloid deposition. Supplementation of neprilysin could potentially contribute to Alzheimer’s disease treatment. When considering the use of adipose tissue-derived stem cells
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Investigation of neuroprotective and therapeutic effects of cannabidiol in an acute coronary syndrome model Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-23 M. Dogan Unlu, D. Uysal, N.F. Karakuyu, S. Asci, O. Ozmen, M.Y. Tepebasi
The ischemia–reperfusion (I/R) injury seen in the heart can cause severe damage to essential organs such as the brain. Cannabidiol (CBD) obtained from Cannabis sativa is used today to treat various diseases. This study aimed to demonstrate CBD's neuroprotective and therapeutic properties in rats with brain damage caused by I/R in the heart. Rats were divided into four groups; sham, I/R, I/R + Prophylactic
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Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-23 Qiong Feng, Xiao Li, Ruijuan Liu, Gongping Liu, Ye He, Ting Li
Multiple biological functions of MTMR14 including regulation of autophagy, inflammation and Ca homeostasis have been reported. However, its functional contribution to learning and memory remains unclear. In this study, we investigated whether upregulation of MTMR14 induced cognitive impairment and the underlying mechanisms. MTMR14 level was significantly increased in cells or brain tissues that overexpressed
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Symmetry of synuclein density in autopsied Parkinson’s disease submandibular glands Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-21 Charles H. Adler, Geidy E. Serrano, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Nan Zhang, Michael Glass, Lucia I. Sue, Anthony Intorcia, Thomas G. Beach
Peripheral tissue biopsy in Parkinson’s disease (PD) may be valuable for clinical care, biomarker validation, and as research enrollment criteria. Determine whether submandibular gland pathologic alpha-synuclein (aSyn) density is symmetrical and whether previous needle biopsy caused tissue damage. Thirty autopsy-confirmed PD cases having fixed submandibular gland tissue from one side and frozen submandibular
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Modulation of thioredoxin by chlorogenic acid in an ischemic stroke model and glutamate-exposed neurons Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-21 Ju-Bin Kang, Hyun-Kyoung Son, Dong-Ju Park, Yeung-Bae Jin, Fawad-Ali Shah, Phil-Ok Koh
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Novel neurodigital interface reduces motion sickness in virtual reality Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-19 Milivoj Dopsaj, Wilhelmina Tan, Vladimir Perovic, Zoran Stajic, Nemanja Milosavljevic, Slobodan Paessler, Tomoko Makishima
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TsMS combined with EA promotes functional recovery and axonal regeneration via mediating the miR-539-5p/Sema3A/PlexinA1 signalling axis in sciatic nerve-injured rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-18 Xianbin Wang, Shouxing Hu, Shuai Ouyang, Xiao Pan, Yingxue Fu, Xingyu Chen, Shuang Wu
Enhancing axonal regeneration is one of the most important processes in treating nerve injuries. Both magnetic and electrical stimulation have the effect of promoting nerve axon regeneration. But few study has investigated the effects of -spinal magnetic stimulation (TsMS) combined with electroacupuncture (EA) on nerve regeneration in rats with sciatic nerve injury. In this study, we compared the improvement
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Development of a novel tool to investigate human laughter behaviour and experience Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-17 Ceci Q. Cai, Marie A.E. Mueller, César F. Lima, Gulun Jin, Arabella Turek, Harri Sivasathiaseelan, Stella Guldner, Sophie K. Scott
We present a questionnaire exploring everyday laughter experience. We developed a 30-item questionnaire in English and collected data on an English-speaking sample ( = 823). Based on Principal Component Analysis (PCA), we identified four dimensions which accounted for variations in people’s experiences of laughter: laughter frequency (‘Frequency’), social usage of laughter (‘Usage’), understanding
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High-skilled first-person shooting game players have specific frontal lobe activity: Power spectrum analysis in an electroencephalogram study Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-16 Inhyeok Jeong, Naotsugu Kaneko, Ryogo Takahashi, Kimitaka Nakazawa
First-person shooting (FPS) games are among the most famous video games worldwide. However, cortical activities in environments related to real FPS games have not been studied. This study aimed to determine differences in cortical activity between low- and high-skilled FPS game players using 160-channel electroencephalography. Nine high-skilled FPS game players (official ranks: above the top 10%) and
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Altered connectivity between the central executive network and the salience network in delusion-prone individuals: A resting state eLORETA report Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-15 Margherita Filosa, Elena De Rossi, Giuseppe A. Carbone, Benedetto Farina, Chiara Massullo, Angelo Panno, Mauro Adenzato, Rita B. Ardito, Claudio Imperatori
Although the Triple Network (TN) model has been proposed as a valid neurophysiological framework for conceptualizing delusion-like experiences, the neurodynamics of TN in relation to delusion proneness have been relatively understudied in nonclinical samples so far. Therefore, the main aim of the current study was to investigate the functional connectivity of resting state electroencephalography (EEG)
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Continuous electrical stimulation of superior laryngeal nerve inhibits initiation of swallowing in anesthetized rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-14 Yuta Nakajima, Takanori Tsujimura, Kojun Tsuji, Jin Magara, Makoto Inoue
Pharyngeal electrical stimulation (PES) applies electrical stimulation to pharyngeal mucosa (PhM) and represents a useful approach to improve swallowing function in patients with dysphagia. To determine the optimal PES modality to treat dysphagia, the mechanism underlying the effects of PES on swallowing function must be elucidated. In this study, we evaluated how PES and electrical stimulation of
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GFAP-expressing cells in the adult hypothalamus can generate multiple neural cell lineages in vitro Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-13 Lucile Butruille, Martine Batailler, Pascal Vaudin, Delphine Pillon, Martine Migaud
Adult neural stem cells (NSCs) located in the two canonical neurogenic niches, the subventricular zone (SVZ) and the subgranular zone (SGZ), express the glial fibrillary acidic protein (GFAP). Recently, proliferative activity has been described in the hypothalamus although the characterization of hypothalamic neural stem/progenitor cells (NSPCs) is still uncertain. We therefore investigated whether
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Maternal aerobic exercise decreases the effects of a perinatal Western diet on the short and long-term memory of CD1 mouse progeny Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-13 Minerva Ortiz-Valladares, Ricardo Pedraza-Medina, Salma Rosales-Herrera, Jorge Guzmán-Muñiz
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Interaction between citalopram and omega-3 fatty acids on anxiety and depression behaviors and maintaining the stability of brain pyramidal neurons in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-13 Fayezeh Hosseini, Fatemeh Khakpai, Soheila Fazli-Tabaei, Mohammad Nasehi, Mohammad-Reza Zarrindast
This research was done to examine the combination of citalopram, an antidepressant drug, and omega-3 in a mice model of depression. Mice received citalopram (1 and 2 mg/kg) or omega-3 (10 and 20 mg/kg) daily over 30 days. Then, they were exposed to acute and chronic restraint stress to assess the possible increasing effect of omega-3 on the antidepressant and anxiolytic effects of citalopram. Elevated
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A protocol for high-resolution episcopic microscopy and 3D volumetric analyses of the adult mouse brain Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-13 Benjamin Mitchell, Erica Mu, Laura Currey, Darryl Whitehead, Shaun Walters, Stefan Thor, Maria Kasherman, Michael Piper
The rapid evolution of different imaging modalities in the last two decades has enabled the investigation of the role of different genes in development and disease to be studied in a range of model organisms. However, selection of the appropriate imaging technique depends on a number of constraints, including cost, time, image resolution, size of the sample, computational complexity and processing
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Neuroprotective effect of chrysophanol in Alzheimer disease via modulating the Ca2+/EGFR-PLCγ pathway Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-12 Wei Huang, Qian Chen, Peng Zhou, Shu Ye, Zhengqing Fang
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The relationship of salusins with Parkinson's Disease, Alzheimer's Disease, and acute ischemic stroke: A preliminary study Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-11 Murat Çakır, Hikmet Saçmacı
Neuroinflammation, oxidative stress, and apoptosis play important roles in the pathophysiology of Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and Acute Ischemic Stroke (AIS). Salusin-α and salusin-β peptides, which were shown to be present in many tissues, including the central nervous system, were also shown to be associated with apoptosis, inflammation, and oxidative stress. In the present
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Effects of visual feedback and force level on bilateral ankle-dorsiflexion force control Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-10 Hajun Lee, Tae Lee Lee, Nyeonju Kang
This study investigated the potential effects of visual feedback and force level on bilateral force control capabilities in the lower limbs. Thirty-nine healthy young adults performed bilateral ankle-dorsiflexion isometric force control tasks for different visual feedback conditions, including continuous visual feedback (CVF) and withdrawal of visual feedback (WVF), indicating the removal of visual
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Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-10 Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejima
Physical exercise is known to induce expression of the neuroprotective brain derived neurotrophic factor (BDNF) in the hippocampus. This study examined the effects of physical exercise on hippocampal BDNF expression and the potential benefits for preventing remote secondary hippocampal damage and neurological impairment following intracerebral hemorrhage (ICH). Wistar rats were randomly assigned to
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Affective processing in dysphoria: Evidence from startle probe modulation of ERPs Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-10 Carola Dell'Acqua, Roza Mejza, Simone Messerotti Benvenuti
The hypoactivation of the appetitive and defensive motivational systems in the brain is a feature of depression and might also represent a vulnerability factor for the disorder. A measure that can be employed to investigate both motivational systems is the electroencephalographic response to an acoustic startle probe during affective processing. Particularly, the amplitude of auditory event-related
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VEGF overexpression in transplanted NSCs promote recovery of neurological function in rats with cerebral ischemia by modulating the Wnt signal transduction pathway Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-07 Yizhen Zhu, Ruojing Liu, Xue Zhao, Chaosheng Kang, Dan Yang, Guo Ge
Neural stem cell transplantation is a good method to treat stroke, but the mechanism is still unclear. Therefore, this study aims to explore the regulatory mechanism of VEGF overexpression in transplanted NSCs to promote the recovery of neural function in ischemic rats by regulating Wnt signal transduction pathways. We amplified VEGF gene fragments by PCR and transfected them into NSCs with Ad5 adenovirus
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Unlocking the role of dorsal hippocampal α4β2 nicotinic acetylcholine receptors in Ethanol-Induced conditioned place preference in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-06 Paola Palombo, Roberta Maeda, Caroline Riberti Zaniboni, Sheila Antonagi Engi, Thais Yokoyama, Natalia Bonetti Bertagna, Augusto Anesio, Paula Cristina Bianchi, Thamires Righi, Gabrielle Emily Boaventura Tavares, Caden Souccar, Fernando Bezerra Romualdo da Silva, Fabio Cardoso Cruz
Alcohol Use Disorder (AUD) presents a significant and challenging public health concern, marked by a dearth of effective pharmacological treatments. Understanding the neurobiological underpinnings of AUD is of paramount importance for the development of efficacious interventions. The process of addiction entails the acquisition of associative behaviors, prominently engaging the dorsal region of the
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Intrinsic running capacity associates with hippocampal electrophysiology and long-term potentiation in rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-30 Elina E. Mäkinen, Sanna Lensu, Jan Wikgren, Satu Pekkala, Lauren G. Koch, Steven L. Britton, Miriam S. Nokia
Good aerobic and metabolic fitness associates with better cognitive performance and brain health. Conversely, poor metabolic health predisposes to neurodegenerative diseases. Our previous findings indicate that rats selectively bred for Low Capacity for Running (LCR) show less synaptic plasticity and more inflammation in the hippocampus and perform worse in tasks requiring flexible cognition than rats
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Upregulation of developmentally-downregulated miR-1247-5p promotes neuroprotection and axon regeneration in vivo Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-28 Agnieszka Lukomska, William C. Theune, Matthew P. Frost, Jian Xing, Anja Kearney, Ephraim F. Trakhtenberg
Numerous micro-RNAs (miRNAs) affect neurodevelopment and neuroprotection, but potential roles of many miRNAs in regulating these processes are still unknown. Here, we used the retinal ganglion cell (RGC) central nervous system (CNS) projection neuron and optic nerve crush (ONC) injury model, to optimize a mature miRNA arm-specific quantification method for characterizing the developmental regulation
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Altered neuronal group 1 metabotropic glutamate receptor- and endoplasmic reticulum-mediated Ca2+ signaling in two rodent models of Alzheimer’s disease Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-02 Aidan Kaar, Megan P. Weir, Mark G. Rae
Calcium mobilization from the endoplasmic reticulum (ER) induced by, for example, IP receptor (IPR) stimulation, and its subsequent crosstalk with extracellular Ca influx mediated through voltage-gated calcium channels VGCCs) and neuronal store-operated calcium entry (nSOCE), is essential for normal neuronal signaling and cellular homeostasis. However, several studies suggest that chronic calcium dysregulation
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Effects of α7 nicotinic acetylcholine receptor agonist against α-synuclein-induced neurotoxicity Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-26 Shinnosuke Takizawa, Kazuki Ohuchi, Ayaka Fujimaki, Taisei Ito, Takanori Murakami, Hisaka Kurita, Masatoshi Inden
The α7 neuronal nicotinic acetylcholine receptor (α7 nAChR) is a potential target for the development of Parkinson’s disease (PD) therapeutics. α-Synuclein (α-Syn), a principal component of Lewy bodies (cytoplasmic inclusions), is a major contributor to PD pathophysiology. Previous studies have demonstrated that activating α7 nAChR protects against nigrostriatal dopamine degeneration in acute and chronic
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COX2 expression plays a role in spinal cord injury-induced neuropathic pain Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-28 Masakazu Toi, Tachibana Toshiya, Koichi Noguchi, Hiroki Yamanaka, Kimiko Kobayashi, Masamichi Okubo, Kazuya Kishima, Yi Dai
Background context Elucidating the mechanism of neuropathic pain (NeP) is crucial as it can result in motor dysfunction and negatively impact quality of life in patients with spinal cord injury (SCI). Although it has been reported that cyclooxygenase 2 (COX2) is involved in NeP in rat models of peripheral nerve injury and that COX2 inhibitors can alleviate NeP, these mechanisms after SCI have not been
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Exercise-induced expression of genes associated with aging in the hippocampus of rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-24 Hyo Youl Moon, Minchul Lee
Recent research has underscored the influence of aging and exercise on brain function. In this study, we aimed to explore alterations in the expression of novel molecular factors and gain insight into underlying molecular mechanisms in the hippocampus of rats engaged in voluntary wheel running. We assessed the expression of aging-related genes in the hippocampus using a high-throughput whole genome
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Luteolin amends neural neurotransmitters, antioxidants, and inflammatory markers in the cerebral cortex of Adderall exposed rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-23 Khaled M.M. Koriem, Noura H.T. El-Soury
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Hippocampal acetylcholine receptor activation-dependent long-term depression in streptozotocin-induced diabetic rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-20 Hayuma Otsuka, Sachie Sasaki-Hamada, Hitoshi Ishibashi, Jun-Ichiro Oka
Cholinergic innervation of the hippocampus correlates with memory formation. In a well-established animal model of type 1 diabetes mellitus, obtained by injecting young adult rats with streptozotocin (STZ), reductions have been reported in the expression of acetylcholine receptors and choline acetyltransferase. In this study, we showed that long-term synaptic depression (LTD) induced by carbachol (CCh)
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Terazosin produces an antidepressant-like effect in mice exposed to chronic unpredictable mild stress behavioral alteration Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-22 Nirav Yogesh Bhatia, Gaurav Mahesh Doshi
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Emotional congruency between faces and words benefits emotional judgments in women: An event-related potential study Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-17 Vladimir Huerta-Chavez, Julieta Ramos-Loyo
The present study aimed to investigate the effects of emotional congruency between faces and words on word evaluation through event-related brain potentials (ERPs). To this end, 20 women performed a face-word congruency task in which an emotional face was presented simultaneously with an affective word in a non-superimposed format. Participants had to evaluate the emotional valence of the word in three
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Sports game intervention aids executive function enhancement in children with autism - An fNIRS study Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-17 Hao Chen, Qi Liang, Baijie Wang, Hexiang Liu, Guijun Dong, Kefeng Li
Executive dysfunction is a prevalent issue in children diagnosed with autism spectrum disorder (ASD). While the efficacy of physical exercise in enhancing cognitive abilities in these children is well-documented, research exploring the relationship between physical exercise and brain function remains limited. This study aimed to investigate the impact of cognitively stimulating exercise on executive
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The cognitive neural mechanism of trait anxiety influences mind wandering: An ERP study Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-19 Qin Jiang, Wenxia Lin, Yu Pan, Dongfang Li, Qi Wang
Converging evidence from behavioral and neuroscience studies demonstrated that our attention to the external world is influenced by emotion, especially anxiety. However, little is known about how trait anxiety influences neural and behavioral responses during mind wandering. The present study aimed to examine the neural and cognitive time courses of how trait anxiety affects mind wandering. Event-related
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Microglia nuclear receptor corepressor 1 deficiency alleviates neuroinflammation in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-17 Shuqin Qiu, Zihong Xian, Junyu Chen, Peng Huang, Honghao Wang, Haitao Wang, Jiangping Xu
Given the established role of nuclear receptor corepressor 1 (NCoR1) in sensing environmental cues and the importance of inflammation in neurodegenerative diseases, elucidation of NCoR1 involvement in neuroinflammation has notable implications. Yet, its regulatory mechanism remains largely unclear. Under in vitro conditions, NCoR1 expression peaked and then decreased at 12 h after lipopolysaccharides
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Semantic transparency modulates the semantic perception of morphemes: Evidence from RSA of BOLD signals Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-21 Wenjia Zhang, Zhiqiang Yan, Qiufeng Dong, Jie Dong, Yan Lu, Xu Duan, Hao Yan
There is no converging evidence on how a word’s semantic transparency affects morphemes’ potential semantic activation. The inconsistent results may be due to the limitation of traditional univariate analyses, in which the semantic transparency was treated as discrete categories. In the current study, Chinese two-character words were used as stimuli and functional magnetic resonance imaging (fMRI)
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The effects of the cholinergic system on carrageenan-induced arthritis Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-21 Min Ha Kim, Hye Rim Suh, Hee Chul Han
The cholinergic system has been found to make an anti-inflammatory effect through the cholinergic anti-inflammatory pathway (CAIP), which suppresses the production of pro-inflammatory cytokines by secreting acetylcholine, a major neurotransmitter. However, no studies have been conducted on the effects of CAIP on joint pain and inflammation. In this study, we investigated the effects of muscarinic acetylcholine
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Functional connectivity via the dorsolateral prefrontal cortex in the late phase of rest periods predicts offline learning Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-17 Ryushin Kawasoe, Sou Takano, Yui Yasumoto, Yuhi Takeo, Kojiro Matsushita, Hisato Sugata
The relationship between offline learning gains and functional connectivity (FC) has been investigated in several studies. They have focused on average motor task performance and resting-state FC across subjects. Generally, individual differences are seen in both offline learning gain and neurophysiological profiles in resting-state FC. However, few studies have focused on the relationship between
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Effectiveness of transcutaneous vagus nerve stimulation (tVNS) on salicylate-induced tinnitus Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-13 Mitra Rezapour, Maryam Farrahizadeh, Mehdi Akbari
Introduction Tinnitus is the most common symptom of auditory system disorders. It affects the quality of life of millions of people, but it is still incurable in most cases. Vagus nerve stimulation (VNS) therapy is a potential new treatment for subjective tinnitus. In this study, transcutaneous vagus nerve stimulation (tVNS) combined with tones was utilized to treat salicylate-induced tinnitus since
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Role of complement activation and disruption of the blood–brain barrier in the pathogenesis of multiple system atrophy Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-14 Makoto Shibata, Koki Makioka, Takumi Nakamura, Hiroo Kasahara, Tsuneo Yamazaki, Masamitsu Takatama, Koichi Okamoto, Yoshio Ikeda
Multiple system atrophy (MSA) is a progressive and sporadic neurodegenerative disorder characterized by the histological appearance of glial cytoplasmic inclusions primarily composed of α-synuclein. Recently, complement-mediated neuroinflammation has been proposed as a key factor in the pathogenesis of numerous neurodegenerative disorders. We conducted immunohistochemical/immunofluorescent assays targeting
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Identification of differentially expressed exosome proteins in serum as potential biomarkers for cognitive impairments in cerebral small vessel disease Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-10 Qian Feng, Yanjing Lu, Ruyang Zhang, Yifan Li, Zhong Zhao, Hua Zhou
Background Cognitive impairment arising from cerebral small vessel disease (CSVD) represents a critical subtype of vascular cognitive impairments (VCI) and is the primary cause of vascular dementia. However, identifying reliable clinical and laboratory indicators for this disease remain elusive. We hypothesize that plasma exosome proteins hold the potential to serve as biomarkers for the onset of cognitive
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Is providing choices always a good thing? the backfire effect of providing choices on competence restoration Neurosci. Lett. (IF 2.5) Pub Date : 2024-01-12 Yue He, Zan Mo, Hui Fang, Mengyin Li
Grounded in self-determination theory (SDT), the purpose of this research is to investigate the influence of providing choices following competence frustration on one’s intrinsic motivation in a follow-up task. Study 1 conducted a between-group EEG experiment with 50 participants and used a component of event-related potentials (ERPs) to represent intrinsic motivation. Study 2 was a behavioural experiment