Commonly used methods to measure whole gut transit time in rodents have yet to combine high sensitivity, objectivity, and automation. We have developed a novel method using oral gavage of non‐toxic fluorescent dye particles and their detection by fluorescence imaging to enable unbiased automated detection of gut transit time simultaneously in 8 cages.

BACKGROUND Constipated patients remain dissatisfied with current treatments suggesting a need for alternative therapies. AIM Evaluate the mechanistic effects of oral vibrating capsule in chronic idiopathic constipation (CIC) by examining the temporal relationships between the onset of vibrations, complete spontaneous bowel movements (CSBM), and circadian rhythm. METHODS In post hoc analyses of two

BACKGROUND Recent data substantiate the importance of acute gastroenteritis in the development of irritable bowel syndrome (IBS). An animal model of postinfectious IBS determined the importance of cytolethal distending toxin B (CdtB) during live Campylobacter jejuni infection and its development of autoimmunity to vinculin. In this study, we examine whether subcutaneous exposure to CdtB alone is sufficient

Gaston Vantrappen passed away on February 11, 2020, in the presence of his wife and family. As the youngest of his mentees, I want to reflect on the significance of his life for the field of Neurogastroenterology and Motiliy. With the passing away of Gaston Vantrappen, the world lost a truly remarkable clinician, mentor and researcher, and a man with great leadership qualities. His dedication to Gastrointestinal

The pathophysiology of irritable bowel syndrome and the detection of biomarkers of specific mechanisms and/or predictors of therapeutic response remain elusive. This roadblock reflects, in large part, the complexity and heterogeneity of the disorder. Recently, there has been growing evidence of a dietary and/or microbiome interaction with the host that may trigger symptoms in a subset of patients.

We have read with interest the paper by Hoshikawa et al,1 addressing a very important issue in our clinical practice, that is, the so‐called proton pump inhibitor (PPI) dependence in patients with gastro‐esophageal reflux disease (GERD) symptoms. Indeed, the management of these patients is challenging since, even following a more accurate assessment with sophisticated and not widely available techniques

We read with interest the letter to the Editor by Dr Ribolsi and Dr Cicala with regard to our recent paper published in the journal. We thank them for their insightful contribution to the discussion around proton pump inhibitor (PPI) dependency and exacerbation of gastro‐esophageal reflux symptoms upon withdrawing PPIs. In our study, rebound symptoms on stopping PPIs appeared to occur in patients with

With saddened hearts, we share the passing of Dr Sidney F. Phillips, the Karl F. and Marjory Hasselmann Professor of Research and Consultant in Gastroenterology and Hepatology at the Mayo Clinic in Rochester, Minnesota. Dr Phillips died on November 9, 2019, in St. Paul, Minnesota. We also celebrate the achievements and humanistic qualities of our mentor. Sid was a researcher, clinician, and educator

The duodenal epithelium plays a pivotal role in the uptake and transport of dietary nutrients while simultaneously acting as physical and biochemical barrier to protect against harmful bacteria and antigens. In the case of functional dyspepsia (FD), the duodenum is of particular interest, due to observed local immune involvement and the proximity to the stomach and exposure to acidopeptic secretions

Intestinal resident macrophages play a crucial role in homeostasis and have been implicated in numerous gastrointestinal diseases. While historically believed to be largely of hematopoietic origin, recent advances in fate‐mapping technology have unveiled the existence of long‐lived, self‐maintaining populations located in specific niches throughout the gut wall. Furthermore, the advent of single‐cell

Colonic manometry with intraluminal bisacodyl infusion can be used to assess colonic neuromuscular function in children with treatment‐refractory constipation. If bisacodyl does not induce high‐amplitude propagating contractions (HAPCs), this can be an indication for surgical intervention. A detailed characterization of the colonic response to intraluminal bisacodyl in children with constipation may