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Exome sequencing of a Pakistani family with spastic paraplegia identified an 18 bp deletion in the cytochrome B5 domain of FA2H Neurol. Res. (IF 2.401) Pub Date : 2020-11-27 Safdar Abbas; Beatrice Brugger; Muhammad Zubair; Sana Gul; Jasmin Blatterer; Julian Wenninger; Khurram Rehman; Benjamin Tatrai; Muzammil Ahmad Khan; Christian Windpassinger
ABSTRACT Hereditary spastic paraplegias (HSPs) are a diverse class of neurodegenerative disorders that mainly affect the corticospinal tract of the body and result in various clinical conditions such as lower limb spasticity and muscle weakness in the lower extremities. Worldwide, more than 70 chromosomal loci/genes have been reported to be associated with HSPs, out of which, six genes viz., ATL1,
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Acute and long-term impairments regarding emotional symptoms and quality of life in patients suffering from transient ischemic attack and stroke Neurol. Res. (IF 2.401) Pub Date : 2021-01-22 Alexander Prost; Katharina Kubitz; Johann Pelz; Carsten Hobohm; Andreas Hinz; Dominik Michalski
ABSTRACT Objectives: Ischemic stroke (IS) is often associated with long-lasting physical deficits, linked to emotional symptoms (ES) and lowered quality of life (QoL). However, recent observations raised doubts regarding the traditional perspective of solely impairment-driven ES. In fact, anxiety and depression were also reported after transient ischemic attack (TIA) with a per definition absence of
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A Systematic Review and Meta-Analysis on Effect of Beta-Blockers in Severe Traumatic Brain Injury Neurol. Res. (IF 2.401) Pub Date : 2021-01-22 William A. Florez-Perdomo; Edgar Felipe Laiseca Torres; Sergio a Serrato; Tariq Janjua; Andrei F. Joaquim; Luis Rafael Moscote-Salazar
ABSTRACT Objectives: Systematically review the medical literature for the impact of beta-blockers on mortality and functional capacity in patients who suffered severe traumatic brain injury. Data Sources: The search included MEDLINE, EMBASE, and Ovid Evidence-Based Medicine, clinical trial registries, and bibliographies. Study Selection: All articles that reported outcome in TBI patients treated with
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Association between insulin resistance and aspirin or clopidogrel resistance in Chinese patients with recent ischemic stroke/TIA Neurol. Res. (IF 2.401) Pub Date : 2021-01-17 Weili Jia; Qian Jia; Yumei Zhang; Xingquan Zhao; Yongjun Wang
ABSTRACT Objective: This study aims to discover whether insulin resistance is an independent predictor for antiplatelet drug resistance in patients with ischemic cerebrovascular disease. Methods: This study used a prospective cohort method. Patients diagnosed as minor ischemic stroke or transient ischemic attack (TIA) were enrolled successively. All patients have been administrated aspirin and/or clopidogrel
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Evaluation of a rabbit model of adjacent intervertebral disc degeneration after fixation and fusion and maintenance in an upright feeding cage Neurol. Res. (IF 2.401) Pub Date : 2021-01-17 Long Hei; Zhaohui Ge; Wenqi Yuan; Ling Suo; Zhigang Suo; Leilei Lin; Huiqiang Ding; Yusheng Qiu
ABSTRACT Purpose: To establish an animal model of adjacent intervertebral disc degeneration by performing spinal fixation and fusion after percutaneous needle puncture and removal of the intervertebral disc or percutaneous needling of the vertebral body without removal of the intervertebral disc. Methods: We established a model of adjacent intervertebral disc degeneration after spinal fixation and
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Application of the P300 potential in cognitive impairment assessments after transient ischemic attack or minor stroke Neurol. Res. (IF 2.401) Pub Date : 2021-01-14 Yaqing Zhang; Haoming Xu; Yuan Zhao; Lei Zhang; Yumei Zhang
ABSTRACT Background The aims of this study were to determine the relationships between changes inlatency and amplitude of the P300 event-related potential component and cognitive impairmentsin patients after a transient ischemic attack (TIA) or a minor stroke and to assess thesuitability of the P300 for screening for cognitive impairments. Material and Method Sixty-five TIA or minor stroke patients
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Impact of β-range-induced oscillatory activity on human input–output relationship of the corticospinal pathway Neurol. Res. (IF 2.401) Pub Date : 2021-01-13 Alessandro Rossi; Matteo Feurra; Simone Rossi; Emiliano Santarnecchi; Federica Ginanneschi
ABSTRACT Objective: The aim of the study was to show that short-lasting (90 s) transcranial alternating current stimulation (tACS) at 20 Hz delivered over the left primary motor cortex (M1) is able to change the shape of recruitment curve of the corticospinal pathway. Methods: The corticospinal pathway was studied during tACS by means of the relationship between the intensity of transcranial magnetic
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NF-κB 1-induced LINC00665 regulates inflammation and apoptosis of neurons caused by spinal cord injury by targeting miR-34a-5p Neurol. Res. (IF 2.401) Pub Date : 2021-01-12 Qilong Deng; Lili Ma; Ting Chen; Yu Yang; Yuetao Ma; Lizhong Ma
ABSTRACT Background: Spinal cord injury (SCI) has high disability rate and low cure rate, which frustrates the patients and brings a heavy burden to their families. This study aimed to explore whether NF-κB1 could induce the expression of LINC00665 and form a feedback loop with miR-34a-5p to regulate inflammation and apoptosis of neurons. Results: Basso, Beattie, and Bresnahan (BBB) scoring was decreased
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Real world prognosis in MS: does early versus late diagnosis matter? Neurol. Res. (IF 2.401) Pub Date : 2021-01-12 Jikku Zachariah; Timothy Quezada; Troy Desai; Rebecca E. Schorr; Thomas F. Scott
ABSTRACT Background Multiple sclerosis (MS) often presents soon after the onset of a recognized clinically isolated syndrome (CIS). In order to interpret data from CIS trials, it is important to know whether patients presenting as classical CIS provide group data representative of RRMS. Objective We aimed to determine whether or not MS patients presenting soon after the onset of symptoms with clinically
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Premutations in the FMR1 gene in Serbian patients with undetermined tremor, ataxia and parkinsonism Neurol. Res. (IF 2.401) Pub Date : 2021-01-06 Milica Pešić; Nataša Dragašević Mišković; Ana Marjanović; Valerija Dobričić; Nela Maksimović; Marina Svetel; Dijana Perović; Ivana Novaković; Sanja Cirković; Iva Stanković; Vladimir Kostić
ABSTRACT Introduction: Although one of the most common monogenic late-onset neurodegenerative disorders, fragile-X-associated tremor/ataxia syndrome (FXTAS) is still underdiagnosed. The aim of the present study was to estimate the frequency of premutation carriers in patients with unexplained degenerative ataxias, action tremor or parkinsonism, and action tremor with or without associated cognitive
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In spontaneous intracerebral hematoma patients, prediction of the hematoma expansion risk and mortality risk using radiological and clinical markers and a newly developed scale Neurol. Res. (IF 2.401) Pub Date : 2021-01-05 Bulent Bakar; Suleyman Akkaya; Bahar Say; Ulas Yuksel; Aslihan Alhan; Esra Turğut; Mustafa Ogden; Ufuk Ergun
ABSTRACT Objective: In patients with spontaneous intracerebral hematoma (ICH), early-stage hematoma expansion has been associated with poor prognosis in literature. This study aimed to develop predictive parameter(s) as well as a new scale to define hematoma expansion and short-term prognosis in patients with ICH. Methods: In 46 patients with ICH, Glasgow Coma Scale (GCS) scores, non-contrast CT (NCCT)
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Advantages of magnetoencephalography, neuronavigation and intraoperative MRI in epilepsy surgery re-operations Neurol. Res. (IF 2.401) Pub Date : 2021-01-05 Julia Shawarba; Burkhard Kaspar; Stefan Rampp; Fabian Winter; Roland Coras; Ingmar Blumcke; Hajo Hamer; Michael Buchfelder; Karl Roessler
ABSTRACT Objective: Management of patients after failed epilepsy surgery is still challenging. Advanced diagnostic and intraoperative tools including magneto-encephalography (MEG) as well as neuronavigation and intraoperative magnetic resonance imaging (iopMRI) may contribute to a better postoperative seizure outcome in this patient group. Methods: We retrospectively analyzed consecutive patients after
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Down regulation of DNA topoisomerase IIβ exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson’s disease by Down regulating tyrosine hydroxylase Neurol. Res. (IF 2.401) Pub Date : 2021-01-05 Kiyak Bercem Yeman; Sevim Isik
ABSTRACT Initiating the transcriptional activation of neuronal genes, DNA topoisomerase IIβ (topo IIβ) has a crucial role in neural differentiation and brain development. Inhibition of topo IIβ activity causes shorter axons and deteriorated neuronal connections common in neurodegenerative diseases. We previously reported that topo IIβ silencing could give rise to neurodegeneration through dysregulation
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Association of inflammatory and platelet volume markers with clinical outcome in patients with anterior circulation ischaemic stroke after endovascular thrombectomy Neurol. Res. (IF 2.401) Pub Date : 2021-01-05 Zhongyun Chen; Yanbo He; Yingying Su; Yijia Sun; Yingbo Zhang; Hongbo Chen
ABSTRACT Background: To determine the correlation of inflammatory and platelet volume indices with the severity of stroke and 3-month clinical outcomes in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). Methods: A retrospective analysis was conducted for AIS patients who underwent EVT at our hospital from 2015 to 2019. Inflammatory factors, including white blood count
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Impact of shoulder subluxation on peripheral nerve conduction and function of hemiplegic upper extremity in stroke patients: A retrospective, matched-pair study Neurol. Res. (IF 2.401) Pub Date : 2021-01-05 Xiangzhe Li; Zhiwei Yang; Sheng Wang; Panpan Xu; Tianqi Wei; Xiaomeng Zhao; Xifeng Li; Yanmei Zhang; Ying Li; Na Mei; Qinfeng Wu
ABSTRACT Purpose: To investigate the impact of shoulder subluxation (SS) on peripheral nerve conduction and function of the hemiplegic upper extremity (HUE) in poststroke patients. Methods: Thirty post-stroke patients were selected (SS group: 15 patients, non-SS group: 15 patients, respectively). Evaluation of nerve conduction in upper limbs: the compound muscle action potential (CMAP) amplitude and
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Involuntary, forced or voluntary exercise can ameliorate the cognitive deficits by enhancing levels of hippocampal NMDAR1, pAMPAR1 and pCaMKII in a model of vascular dementia Neurol. Res. (IF 2.401) Pub Date : 2021-01-03 Yangyang Lin; Yangfan Xu; Huiting Feng; Longfei You; Juntao Dong; Zunlin Gao; Suiying Peng; Yujie Deng; Peihui Wu
ABSTRACT Objectives: To investigate the effect on vascular dementia of involuntary exercise induced by functional electrical stimulation and of forced and voluntary exercise, focusing on the recovery of cognitive function and using a rat model of dementia. Methods: A demential model was created in Wistar rats who were then given forced exercise, allowed voluntary exercise (wheel running) or had exercise
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Surround inhibition in patients with juvenile myoclonic epilepsy Neurol. Res. (IF 2.401) Pub Date : 2020-12-31 Bengi Gul Turk; Naz Yeni; Aysegul Gunduz; Ceren Alis; Meral Kiziltan
ABSTRACT Objective In healthy subjects, there is a reduction in the amplitudes of somatosensory-evoked potentials (SEPs) after the simultaneous stimulation of two nerves compared to the sum of separate stimulations. This reduction is due to the inhibition of one area in the cortex after stimulation of the neighboring area, which results from the surround inhibition (SI) phenomenon. In this study, we
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Neurosurgical community in Southeast Europe: expanding the horizons Neurol. Res. (IF 2.401) Pub Date : 2020-12-30 Lukas Rasulić
(2020). Neurosurgical community in Southeast Europe: expanding the horizons. Neurological Research: Vol. 42, Neurosurgical community in Southeast Europe: Expanding the horizons, pp. 993-994.
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Huntington’s disease in Turkey: genetic counseling, clinical features, and outcome Neurol. Res. (IF 2.401) Pub Date : 2020-12-30 Yesim Sucullu Karadag; Busranur Erozan Cavdarli; Rabia Nazik Yuksel
ABSTRACT Objective: This study aims to report the data of genetic counseling and to identify the clinical features of Turkish Huntington’s disease (HD) patients and to investigate its possible relationship with genetic data. Method: A regular weekly outpatient clinic has been held routinely since January 2018. Patients and their referred relatives have been evaluated regarding clinical features and
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Hypoxic stress visualized in the cervical spinal cord of ALS patients Neurol. Res. (IF 2.401) Pub Date : 2020-12-30 Toru Yamashita; Tetsuhiro Hatakeyama; Kota Sato; Yusuke Fukui; Nozomi Hishikawa; Mami Takemoto; Yasuyuki Ohta; Yoshihiro Nishiyama; Nobuyuki Kawai; Takashi Tamiya; Koji Abe
ABSTRACT Objective: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease. Hypoxic stress is suspected as the pathogenesis of ALS, however, no positron emission tomography (PET) study for hypoxic stress has been conducted in the spinal cord of ALS patients. Methods: In the present study, we examined cervical spinal hypoxic stress of nineALS patients with upper extremity
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Establishment and validation of nomogram model for survival predicting in patients with spinal metastases secondary to lung cancer Neurol. Res. (IF 2.401) Pub Date : 2020-12-30 Zhong-Yu Gao; Tao Zhang; Hui Zhang; Cheng-Gang Pang; Wen-Xue Jiang
ABSTRACT Objectives To evaluate the prognostic effect of pre-treatment factors in patients with spinal metastases secondary to lung cancer, and establish a novel predicting nomogram for predicting the survival probability. Methods A total of 209 patients operated for spinal metastases from lung cancer were consecutively enrolled, and divided into the training and validation samples with a ratio of
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Trends of stroke attributable to high sodium intake at the global, regional, and national levels from 1990 to 2019: a population-based study Neurol. Res. (IF 2.401) Pub Date : 2020-12-30 Lina Wang; Jianqiang Du; Wangnan Cao; Shengzhi Sun
ABSTRACT Objectives: High sodium intake is associated with a higher risk of stroke. However, global patterns and trends in the stroke burden attributable to high sodium intake have not been systematically assessed. Methods: We used the numbers and age-standardized mortality rate (ASMR), and disability-adjusted life years (DALYs) rate (ASDR) of the stroke burden attributable to high sodium intake by
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Split phenomenon of antagonistic muscle groups in amyotrophic lateral sclerosis: relative preservation of flexor muscles Neurol. Res. (IF 2.401) Pub Date : 2020-12-29 Jingwen Liu; Zhili Wang; Dongchao Shen; Xunzhe Yang; Mingsheng Liu; Liying Cui
ABSTRACT Objective: In addition to the split hand sign, other split phenomena of different muscles also exist in amyotrophic lateral sclerosis (ALS). We analyzed the incidence of split phenomena in multiple antagonistic muscle groups in ALS patients and explored whether clinical factors affected their occurrence. Methods: 618 ALS patients were included from a single ALS center. Muscle strength in upper
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Posterior Fossa Decompression and superficial durotomy rather than complete durotomy and duraplasty in the management of Chiari 1 Neurol. Res. (IF 2.401) Pub Date : 2020-12-24 Adem Aslan; Usame Rakip; Mehmet Gazi Boyacı; Serhat Yildizhan; Serhat Kormaz; Emre Atay; Necmettin Coban
ABSTRACT Objective: We aimed to evaluate the effectiveness and reliability of posterior fossa decompression (PFD) and superficial durotomy in patients who underwent surgery for Chiari malformation type 1 (CM1). Materials and Methods: Our study included 54 patients with the diagnosis of CM1 who had surgery between January 2012 and June 2019. The patients were divided into two groups according to the
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Prognostic significance of serum translocator protein in patients with spontaneous intracerebral hematoma:preliminary findings Neurol. Res. (IF 2.401) Pub Date : 2020-12-23 Wenqing Jiang; Peng Jin; Qing Bao; Wenfeng Wei; Wei Jiang
ABSTRACT Background: The aim of this study was to measure the level of translocator protein (TSPO) in patients with intracerebral hematoma (ICH) and to determine whether TSPO can predict ICH outcomes. Method: Patients with ICH were recruited at Wujin Hospital Affiliated with Jiangsu University between January 2018 and May 2020. The level of TSPO and inflammatory factors were analyzed by enzyme-linked
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Delayed diagnosis of multiple sclerosis in a low prevalence country. Neurol. Res. (IF 2.401) Pub Date : 2020-12-23 Simón Cárdenas-Robledo; Lorena Lopez-Reyes; Laura Estefanía Arenas-Vargas; Michael Steven Carvajal-Parra; Claudia Guío-Sánchez
ABSTRACT Background: Early diagnosis and treatment of multiple sclerosis (MS) is crucial to avoid future disability. The factors that influence diagnostic delay in low prevalence settings have been poorly studied. Objectives: To evaluate the factors associated with a delayed diagnosis of MS after the symptomatic onset. Methods: Clinical records of confirmed MS patients were reviewed. Diagnostic delay
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Risk factors for in-hospital mortality among acute ischemic stroke patients in China: a nationwide prospective study Neurol. Res. (IF 2.401) Pub Date : 2020-12-23 Zhi-Xin Huang; Hong-Qiu Gu; Xin Yang; Chun-Juan Wang; Yong‐Jun Wang; Zi‐Xiao Li
ABSTRACT Objective: We aimed to investigate factors related to in-hospital mortality (IHM) in acute ischemic stroke (AIS) patients. Methods: We prospectively investigated 827,314 patients who were admitted within 7 days of AIS between August 2015 and July 2019. Demographic characteristics, risk factors, and clinical and laboratory characteristics of patients were assessed. Univariate and multivariate
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Brain volume and perfusion asymmetry in temporal lobe epilepsy with and without hippocampal sclerosis Neurol. Res. (IF 2.401) Pub Date : 2020-12-15 Yiwei Zhang; Wanchen Dou; Zhentao Zuo; Hui You; Yuelei Lv; Bo Hou; Lin Shi; Feng Feng
ABSTRACT Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age 28.4 ± 9.3 years; 28 female/33 male) with unilateral signs of HS (TLE-HS+) and 25 TLE patients (mean age 29.8 ± 8.0 years; 17 female/8 male) without HS (TLE-HS-) were
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Tirofiban combined with heparin’s effect and safety in the treatment of mild to moderate acute ischemic stroke Neurol. Res. (IF 2.401) Pub Date : 2020-12-04 Tao Qiu; Changqing Li; Linming Huang; Hua Xiao; Xiaoyong Deng; Xiaoyan Dai; Shengqi Fu; Juan Wang; Qingping Gong; Qin Luo; Mingjin Wang; Weili He; Ming Chen
ABSTRACT Tirofiban can be used to treat patients with acute ischemic stroke (AIS), this study was to evaluate the efficacy and safety of tirofiban combined with heparin in the treatment of mild to moderate AIS. A total of 98 patients with mild to moderate AIS randomly were divided into 2 groups within 48 h: the treatment group treated with tirofiban and, and the control group treated with aspirin +
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The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection Neurol. Res. (IF 2.401) Pub Date : 2020-12-04 Yongqian Huang; Xing Li; Chunlian Pan; Wei Cheng; Xijia Wang; Zhigang Yang; Lifang Zheng
ABSTRACT Background and purpose: To investigate the effect of Emodin on the inflammatory response of brain tissue and the expression of the TLR3 pathway in mice with herpes virus encephalitis. Method: Twenty male BALB/c mice were randomly divided into the NS group, HSV-1 group, HSV-1 + Emodin group and HSV-1 + ACV group. The histopathological features and the effect of TLR3 expression were observed
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Calpain activity in plasma of patients with essential tremor and Parkinson’s disease: a pilot study Neurol. Res. (IF 2.401) Pub Date : 2020-12-01 Zamira M Muruzheva; Dmitry S Traktirov; Alexander S Zubov; Nina S Pestereva; Maria S Tikhomirova; Marina N Karpenko
ABSTRACT Background : Essential tremor (ET) and Parkinson’s disease (PD) are the two most common movement disorders in adults with similar clinical symptoms, which is hinting towards existence of coincident pathogenesis steps. Objectives : The objective of this report is to characterize the relationship between ET and PD severity and the activity of calcium-dependent proteases calpain in plasma. Methods
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Association of polymorphism -308G/A in tumor necrosis factor-alpha gene (TNF-α) and TNF-α serum levels in patients with relapsing-remitting multiple sclerosis Neurol. Res. (IF 2.401) Pub Date : 2020-11-30 Antonia A. Grigorova; Anastasiya G. Trenova; Spaska A. Stanilova
ABSTRACT TNF-α is an important cytokine of the inflammatory response involved in the pathogenesis of relapsing-remitting multiple sclerosis (RRMS). The aim of this study is to explore the association between the promoter polymorphism −308G/A in the TNF-α gene (rs1800629) with genetic susceptibility to RRMS. Methods: A group of 183 RRMS patients and 169 age and gender-matched healthy controls were enrolled
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A novel idea for establishing Parkinson’s disease mouse model by intranasal administration of paraquat Neurol. Res. (IF 2.401) Pub Date : 2020-11-20 Yi-Bing Chen; Yan-Qiu Wang; Jia-Rong Wu; Yuan-Lu Cui
ABSTRACT Background: In this study, we sought to provide an idea for establishing a novel mouse model for Parkinson’s disease (PD) through intranasal administration of paraquat instead of the conventional method of intraperitoneal injection. Intranasal administration has the potential to lower mortality caused by intraperitoneal paraquat administration. Methods: A paraquat-loaded thermosensitive hydrogel
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LINC00943 knockdown attenuates MPP+-induced neuronal damage via miR-15b-5p/RAB3IP axis in SK-N-SH cells Neurol. Res. (IF 2.401) Pub Date : 2020-11-19 Chunming Meng; Jing Gao; Qingyuan Ma; Qian Sun; Tiantian Qiao
ABSTRACT Objectives Parkinson’s disease (PD) is a neurodegenerative problem correlated with neuronal damage. Long noncoding RNAs (lncRNAs) are implicated in neuronal damage in PD development. This research aims to analyze the function and mechanism of LINC00943 in 1-methyl-4-phenylpyridinium (MPP+)-caused neuronal injury. Methods MPP+-challenged SK-N-SH cells served as a PD-like model of neuronal damage
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Use of BRASS in sedated critically-ill patients as a predictable mortality factor: BRASS-ICU Neurol. Res. (IF 2.401) Pub Date : 2020-11-19 Vincent Legros; Bruno Mourvillier; Thierry Floch; Quentin Candelier; Jeremy Rosman; Bruno Lafont; Jean-Christophe Farkas; Mathieu Bard; Lukshe Kanagaratnam; Philippe Mateu
ABSTRACT Objectives: To demonstrate that a BRASS score≥ 3 at admission of intubated, ventilated and sedated patients is predictive of mortality Methods: we have realized an Observational prospective multicenter study. All Major patients without neurological history, admitted to ICU for a non-neurological cause, sedated and admitted under mechanical ventilation were included. Results: One hundred and
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Application of functional imaging, neuronavigation, and intraoperative MR imaging in the surgical treatment of brain cavernomas Neurol. Res. (IF 2.401) Pub Date : 2020-11-18 Fabian Winter; Lisa Blair; Michael Buchfelder; Karl Roessler
ABSTRACT Objective: The aim of this study was to investigate whether preoperative functional imaging and intraoperative magnetic resonance imaging (iMRI) facilitate surgery and improve outcomes in the surgical treatment of cavernous malformations of the brain (CM). Materials and Methods: Retrospective data analysis was performed for consecutive patients diagnosed with a CM who underwent surgical treatment
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Efficacy of arterial spin labeling magnetic resonance imaging with multiple post-labeling delays to predict postoperative cerebral hyperperfusion in carotid endarterectomy Neurol. Res. (IF 2.401) Pub Date : 2020-11-15 Hidenori Endo; Miki Fujimura; Atsushi Saito; Toshiki Endo; Kazumasa Ootomo; Teiji Tominaga
ABSTRACT Introduction: Cerebral hyperperfusion (CHP) syndrome is one of the most deleterious complications after carotid endarterectomy (CEA). Arterial spin labeling (ASL) is a promising non-invasive method to evaluate various hemodynamic parameters in cerebrovascular diseases. The aim of this study was to clarify whether ASL with multiple post-labeling delays (PLDs) can predict postoperative CHP after
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Can safe and radical resection of all types of parasagittal meningiomas be achievable? —the introduction of a simplified surgical strategy Neurol. Res. (IF 2.401) Pub Date : 2020-11-11 Nan Zhang; Tao Yang; Farrukh Hameed; Xiang Zhang; Yang Yao; Dongxue Li; Changwen Li; Shaojie Yu; Yong Xu; Chengyu Xia; Xianming Fu
ABSTRACT Background: Surgery of parasagittal meningiomas (PSMs) is still technically challenging, for the balance between radical resection and preservation of venous circulation. In this article, we’d systemically introduce the technical nuances of a simplified strategy for radical resection of all types of PSMs. All the cases were operated by one single neurosurgeon from a single institution. Methods:
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Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke Neurol. Res. (IF 2.401) Pub Date : 2020-11-09 Mahmoud Ramdan; Mohammad Reza Bigdeli; Sepideh Khaksar; Abbas Aliaghaei
ABSTRACT Objective Stroke, a cerebrovascular disease, has been introduced as the second cause of death and physical disability in the world. Recently, cell-based therapy has been considered by the scientific community as a promising strategy for reducing ischemic damages. The stem cells of the umbilical cord release growth and neurotrophic factors. The remarkable properties of these cells are the reason
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Subarachnoid hemorrhage in C57BL/6J mice increases motor stereotypies and compulsive-like behaviors Neurol. Res. (IF 2.401) Pub Date : 2020-10-31 Danop Nanegrungsunk; Michael E. Ragozzino; Hao-Liang Xu; Kyle J. Haselton; Chanannait Paisansathan
ABSTRACT Objective Long-term behavioral, mood, and cognitive deficits affect over 30% of patients with subarachnoid hemorrhage (SAH). The aim of the present study was to examine the neurobehavioral outcomes following endovascular perforation induced SAH in mice. Methods C57BL/6 J (B6) mice were exposed to endovascular perforation induced SAH or control surgery. Three weeks later, mice received a series
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Early permanent cerebrospinal fluid diversion in aneurysmal subarachnoid hemorrhage: does a lower rate of nosocomial meningitis outweigh the risk of delayed cerebral vasospasm related morbidity? Neurol. Res. (IF 2.401) Pub Date : 2020-10-26 Davide Marco Croci; Martina Dalolio; Soheila Aghlmandi; Ethan Taub; Jonathan Rychen; Alessio Chiappini; Daniel Zumofen; Raphael Guzman; Luigi Mariani; Michel Roethlisberger
ABSTRACT Objective: Early permanent cerebrospinal fluid (CSF) diversion for hydrocephalus during the first 2 weeks after aneurysmal subarachnoid hemorrhage (aSAH) shortens the duration of external ventricular drainage (EVD) and reduces EVD-associated infections (EVDAI). The objective of this study was to detect any association with symptomatic delayed cerebral vasospasm (DCVS), or delayed cerebral
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BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice Neurol. Res. (IF 2.401) Pub Date : 2020-10-19 Jie Wang; Weiwei Hu; Zehua Feng; Meijiang Feng
ABSTRACT Objective To investigate the beneficial effect of brain-derived neurotrophic factor (BDNF) -overexpressing human umbilical cord mesenchymal stem cell (hUC-MSC)-derived motor neurons in the human Cu, Zn-superoxide dismutase1 (hSOD1)G93A amyotrophic lateral sclerosis (ALS) mice. Methods The BDNF gene was transfected into hUC-MSC-derived motor neurons by the lentivirus-mediated method. hSOD1G93A
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Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-κB pathway in glioma Neurol. Res. (IF 2.401) Pub Date : 2020-10-18 HaiTao Ding; Lihai Cui; Changmei Wang
ABSTRACT Aim This study aimed to explore the role of lncRNA leukemia inhibitory factor receptor antisense RNA 1 (LIFR-AS1) on glioma and its underlying molecular mechanism. Methods The expression of LIFR-AS1 and miR-4262 was detected by quantitative real-time polymerase chain reaction (qRT-RCR) in both glioma tissues and cell lines. Colony formation assay, 5-ethynyl-20-deoxyuridine (EdU) assay, flow
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Dexmedetomidine improves postoperative neurocognitive disorder after cardiopulmonary bypass in rats Neurol. Res. (IF 2.401) Pub Date : 2020-10-19 Zhiwei Gao; Zhengfen Li; Rui Deng; Qing Liu; Qiuxia Xiao; Jiang Han; Cuixia Pu; Ying Zhang
ABSTRACT Purpose To investigate whether dexmedetomidine can improve postoperative neurocognitive function after cardiopulmonary bypass in rats. Methods A total of 45 male Sprague Dawley (SD) rats were randomly divided into sham group, control group, and dexmedetomidine (Dex) group. The rats in the sham group received skin excision and blood vessel ligation treatment, rats in the control group received
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Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis Neurol. Res. (IF 2.401) Pub Date : 2020-10-15 Masayuki Sato; Takumi Nakamura; Kazuaki Nagashima; Yukio Fujita; Yoshio Ikeda
ABSTRACT A nerve conduction study (NCS) is routinely undertaken for the differential diagnosis of amyotrophic lateral sclerosis (ALS). Prolonged median motor distal latency (MMDL) has been reported in a subset of patients with ALS. This study aimed to investigate the clinical importance of NCS characteristics in patients with ALS. A total of 75 patients who underwent NCS were enrolled in this study
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P-Tau as prognostic marker in long term follow up for patients with shunted iNPH Neurol. Res. (IF 2.401) Pub Date : 2020-10-15 Karol Migliorati; Pier Paolo Panciani; Marta Pertichetti; Barbara Borroni; Silvana Archetti; Luca Rozzini; Alessandro Padovani; Lodovico Terzi; Sara Bruscella; Marco Maria Fontanella
ABSTRACT Objective: Diagnosis of idiopathic Normal Pressure Hydrocephalus (iNPH) relies solely on clinical and radiological criteria while, unlike other neurological diseases, the analysis of cerebrospinal fluid markers is not used in clinical practice. Nevertheless, the overlapping of neurodegenerative diseases affects the long-term shunt efficacy and this occurrence should be detected before surgery
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Anterolateral approach for subaxial vertebral artery decompression in the treatment of rotational occlusion syndrome: results of a personal series and technical note Neurol. Res. (IF 2.401) Pub Date : 2020-10-15 Sabino Luzzi; Cristian Gragnaniello; Alice Giotta Lucifero; Stefano Marasco; Yasmeen Elsawaf; Mattia Del Maestro; Samer K. Elbabaa; Renato Galzio
ABSTRACT Objectives To report the results of a retrospective series and a technical note about the anterolateral approach for the treatment of the rotational occlusion syndrome (ROS) involving the subaxial V2 segment of the vertebral artery (VA). Methods We retrospectively reviewed the data of a cohort of patients that underwent an anterolateral approach to decompress the VA as they suffered from ROS
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Determination of cerebral blood flow velocity and microembolic signals in essential thrombocytosis by transcranial doppler ultrasonography Neurol. Res. (IF 2.401) Pub Date : 2020-10-14 Ahmet Cinar; Guven Cetin; Ozge Altintas Kadirhan; Seda Turgut; Iskender Ekinci; Talip Asil
ABSTRACT Objectives The goal of treatment in essential thrombocytosis (ET) is to prevent vascular complications such as thrombosis and hemorrhage. This study aimed to evaluate the risk of cerebrovascular microembolism in ET patients due to detection of microembolic signals (MES) and measure cerebral blood flow velocity (CBFV) by Transcranial Doppler (TCD) ultrasonography. Material and Methods In this
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Vitality index is a predictor of the improvement in the functional independence measure score in subacute stroke patients with cognitive impairment Neurol. Res. (IF 2.401) Pub Date : 2020-10-14 Daisuke Ito; Naoki Mori; Ayaka Shimizu; Ayako Fuji; Sachiko Sakata; Kunitsugu Kondo; Michiyuki Kawakami
ABSTRACT Objectives To investigate the effect of motivation on improvements in the Functional Independence Measure (FIM) scores in subacute stroke patients with cognitive impairment. Methods This retrospective cohort study included 358 consecutive subacute stroke patients with first-ever stroke and Mini-Mental State Examination score ≤23 at admission. We determined motivation and rehabilitation outcome
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Two-dimensional structure analysis of hemifacial spasms and surgical outcomes of microvascular decompression Neurol. Res. (IF 2.401) Pub Date : 2020-10-12 Shiyuan Han; Yongning Li; Zhimin Li; Xin Wang; Jun Gao
ABSTRACT Background Although studies have indicated that the small posterior fossa plays a role in hemifacial spasm (HFS), few studies have denoted the correlations between local measurements of the cerebellopontine angle and the incidence of HFS and surgical outcomes. Methods We retrospectively analyzed the demographic and clinical data of HSF patients who underwent microvascular decompression at
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Coping strategies used by patients with relapsing multiple sclerosis from Argentina: correlation with quality of life and clinical features Neurol. Res. (IF 2.401) Pub Date : 2020-10-10 Edgar Carnero Contentti; Pablo A. López; Ricardo Alonso; Barbara Eizaguirre; Juan Pablo Pettinicchi; Santiago Tizio; Verónica Tkachuk; Alejandro Caride
ABSTRACT Background Multiple sclerosis (MS) is a chronic neurodegenerative and inflammatory disease. The adaptation to MS depends on the effectiveness of coping, which moderates the process of adaptation and psychological well-being. Objectives We aimed to analyze the coping strategies of an Argentinean population of patients with MS (PwMS) and their association with clinical variables and health-related
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Assessments of regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration: a transected sciatic nerve model in rat Neurol. Res. (IF 2.401) Pub Date : 2020-10-09 Pouria Ebrahimi-Zadehlou; Alireza Najafpour; Rahim Mohammadi
ABSTRACT Purpose It is compulsory to make a tension-free, end-to-end repair in transected injuries. However, when it comes to longer defects, placement of an autograft or nerve conduits is required. The present study was designed to assess regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration in a transected sciatic nerve model in rat. Methods
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Functional outcome after critical illness in older patients: a population-based study Neurol. Res. (IF 2.401) Pub Date : 2020-10-04 Mania Hajeb; Tarun D Singh; Amra Sakusic; Jonathan Graff-Radford; Ognjen Gajic; Alejandro A. Rabinstein
ABSTRACT Purpose To determine the prevalence of disability among ICU survivors one year after admission, and which factors influence functional outcome. Methods We examined consecutive patients enrolled in the population-based Mayo Clinic Olmsted Study of Aging and then admitted to medical or surgical adult ICUs at Mayo Clinic, Rochester between January 1, 2006, and December 31, 2014 to determine one-year
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A Novel Variant in CWF19L1 Gene in a Family with Late-Onset Autosomal Recessive Cerebellar Ataxia 17 Neurol. Res. (IF 2.401) Pub Date : 2020-10-04 Hussein Algahtani; Bader Shirah; Samah Almatrafi; Mohammad H. Al-Qahtani; Angham Abdulrahman Abdulkareem; Muhammad Imran Naseer
ABSTRACT Introduction Previously published studies demonstrated that mutations in CWF19L1 cause early-onset autosomal recessive cerebellar ataxia 17. In this article, we report a novel homozygous missense variant in CWF19L1 in two sisters who had late-onset cerebellar ataxia with epilepsy and describe their clinical and neuroradiological findings. Methods We included two female patients with typical
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Propofol ameliorates neuropathic pain and neuroinflammation through PPAR γ up-regulation to block Wnt/β-catenin pathway. Neurol. Res. (IF 2.401) Pub Date : 2020-09-27 Peng Jiang,Qun Jiang,Yan Yan,Zhiqi Hou,Dexing Luo
ABSTRACT Objective As an intravenous anesthetic, propofol has been exhibited to provide excellent clinical analgesia. Whether propofol has amelioration property for NP and neuroinflammation remains unexplored. The present study was arranged to probe the role of propofol in the mitigation of NP and neuroinflammation in rats and underlying mechanisms. Methods Rats were randomly classified into the following
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Can the electrically stimulated manual muscle test differentiate upper from lower motor neuron injury in persons with acute SCI? Neurol. Res. (IF 2.401) Pub Date : 2020-09-24 Ashley de Padua,Cassandra Renfro,Maria Grabnar,Kevin Kilgore,Anne Bryden,Mary Joan Roach,Greg Nemunaitis
Objective To determine if the motor response on the stimulated manual muscle test (SMMT) in muscles with a grade 0 motor score on the manual muscle test (MMT) can differentiate lower motor neuron (LMN) from upper motor neuron (UMN) injury based on the presence of spontaneous activity (SA) with needle EMG. Design Prospective Study. Participants/Methods Twenty-one subjects with acute traumatic cervical
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Systematic review of trauma system regionalization and implementation on outcomes in traumatic brain injury patients Neurol. Res. (IF 2.401) Pub Date : 2020-09-24 Berje H. Shammassian; Luke Wooster; James M. Wright; Michael L. Kelly
ABSTRACT Background The number of trauma systems has increased dramatically within the United States over the past 40 years. The implementation of these systems has contributed to a decrease in mortality and improved outcomes in patients with trauma. Several studies have evaluated the effect of implementation of these systems on outcomes, but few studies examine the effects of such systems specifically
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Screening for cognitive impairment with the montreal cognitive assessment at six months after stroke and transient ischemic attack. Neurol. Res. (IF 2.401) Pub Date : 2020-09-23 Lijun Zuo,Xiaoling Liao,Yuesong Pan,Xianglong Xiang,Xia Meng,Hao Li,Xingquan Zhao,Yilong Wang,Jiong Shi,Yongjun Wang
ABSTRACT Objective Cognitive impairment usually occurs in the acute phase after stroke, but most stroke survivors experience some form of long-term cognitive deficit. The aim of this study was to establish the cutoff point of the Montreal Cognitive Assessment (MoCA-Beijing) in screening for cognitive impairment (CI) at 6 months of ischemic stroke or transient ischemic attack (TIA). Methods A total
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Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury. Neurol. Res. (IF 2.401) Pub Date : 2020-09-16 Khashayar Afshari,Amir Dehdashtian,Nazgol-Sadat Haddad,Seyedeh Zarifeh Jazaeri,Daniel C Ursu,Mina Khalilzadeh,Arvin Haj-Mirzaian,Saeed Shakiba,Terry C Burns,Seyed Mohammad Tavangar,Mehdi Ghasemi,Ahmad Reza Dehpour
ABSTRACT Objectives To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this effect. Methods Using an aneurysm mini-clip model of contusive SCI, T9-10 laminectomies were performed for 60 male rats. Animals were divided into six experimental groups (n = 10 per group) as follows: a minocycline