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Risk of intracranial hemorrhage in patients using anticoagulant therapy for atrial fibrillation after cerebral microbleeds combined with acute ischemic stroke: a meta-analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Bingqing Zhao, Ye Yuan, Zheng Li, Ying Chen, Yali Gao, Baoling Yang, Jingyi Wu, Weihua Jia
ObjectiveTo evaluate intracerebral hemorrhage (ICH) risk in patients with ischemic stroke (IS) and cerebral microbleeds (CMBs) undergoing anticoagulation therapy for non-valvular atrial fibrillation (AF).MethodsWe conducted a comprehensive search across multiple databases, including Embase, PubMed, Cochrane, UpToDate, Scopus, WOS, and SinoMed. The search covered observational literature published from
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Rethinking the effects of adjuvant beam radiation therapy on overall survival in atypical meningioma patients: age considerations Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Chao Li, Jiajun Qin, Fei Xue, Zhaoli Shen, Qi Lin, Yajun Xue, Xianzhen Chen
BackgroundThis study aimed to investigate the effects of adjuvant beam radiation therapy (ABRT) on overall survival (OS) in patients with primary single intracranial atypical meningioma (AM), with a focus on age-related outcomes.MethodsWe conducted a retrospective study using data from SEER database. Our cohort consisted of patients diagnosed with a primary single intracranial AM tumor and had undergone
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Clinical course of five patients definitively diagnosed with idiopathic perilymphatic fistula treated with transcanal endoscopic ear surgery Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Toshinori Kubota, Tsukasa Ito, Takatoshi Furukawa, Hirooki Matsui, Takanari Goto, Chikako Shinkawa, Han Matsuda, Tetsuo Ikezono, Seiji Kakehata
ObjectivesAn idiopathic perilymphatic fistula (PLF) can be difficult to diagnose because patients present with sudden sensorineural hearing loss (SSHL) and/or vestibular symptoms without any preceding events. In such cases, we currently test for cochlin-tomoprotein (CTP) to confirm the diagnosis of idiopathic PLF because CTP is only detected in the perilymph. In this study, we report the clinical course
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Safety and efficacy of acupuncture for mild cognitive impairment: a study protocol for clinical study Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Jae-Hong Kim, Jeong-Cheol Shin, Ae-Ran Kim, Bok-Nam Seo, Gwang-Cheon Park, Byoung-Kab Kang, Jeong-Soon Lee
BackgroundMild cognitive impairment (MCI) is an intermediary condition between typical cognitive decline that occurs owing to aging and dementia. It is necessary to implement an intervention to slow the progression from MCI to Alzheimer’s disease. This manuscript reports the protocol for a clinical trial on the effect of acupuncture in patients with MCI.MethodsThe trial will be a randomized, prospective
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Efficacy of botulinum toxin A combined with extracorporeal shockwave therapy in post-stroke spasticity: a systematic review Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Ya-nan Du, Yang Li, Ting-yu Zhang, Nan Jiang, Ying Wei, Shi-huan Cheng, He Li, Hao-yang Duan
ObjectivesIn recent years, there has been an increase in the number of randomized clinical trials of BTX-A combined with ESWT for the treatment of post-stroke spasticity. This has made it possible to observe the benefits of combination therapy in clinical practice. Therefore, this paper reviews the effectiveness of BTX-A in combination with ESWT for the treatment of post-stroke spasticity.MethodsBy
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Association between systemic immune-inflammation index and post-stroke depression: a cross-sectional study of the national health and nutrition examination survey 2005–2020 Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Mingzhu Wang, Chengchao Peng, Tingting Jiang, Qiongfang Wu, Danping Li, Min Lu
BackgroundLess research has linked the Systemic Immune Inflammatory Index (SII) with post-stroke depression (PSD). This study aims to look at any potential connections between SII and PSD.MethodsThe National Health and Nutrition Examination Survey (NHANES), conducted in a population that embodied complete SII and stroke data from 2005 to 2020, was used to perform the current cross-sectional survey
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Navigating the vestibular maze: text-mining analysis of publication trends over five decades Front. Neurol. (IF 3.4) Pub Date : 2024-03-15 Amit Wolfovitz, Nir A. Gecel, Yoav Gimmon, Shaked Shivatzki, Vera Sorin, Yiftach Barash, Eyal Klang, Idit Tessler
IntroductionThe field of vestibular science, encompassing the study of the vestibular system and associated disorders, has experienced notable growth and evolving trends over the past five decades. Here, we explore the changing landscape in vestibular science, focusing on epidemiology, peripheral pathologies, diagnosis methods, treatment, and technological advancements.MethodsPublication data was obtained
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POLR3-related leukodystrophy caused by biallelic POLR3A and 1C pathogenic variants: a single-center experience Front. Neurol. (IF 3.4) Pub Date : 2024-03-14 Jing Liu, Yue Niu, Jiong Qin, Zhixian Yang
ObjectivesThis study aimed to investigate the clinical, radiological, and genetic features of POLR3-related leukodystrophy caused by mutations in POLR3A or POLR1C.MethodsFourteen Chinese patients with POLR3-related leukodystrophy were enrolled in this cross-sectional observational study. The clinical manifestations, brain MRI and genetic tests of the patients were evaluated.ResultsThirteen patients
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Association between social determinants of health and pediatric traumatic brain injury outcomes Front. Neurol. (IF 3.4) Pub Date : 2024-03-14 Kendall Parsons, Makda G. Mulugeta, Gabrielle Bailey, Scott Gillespie, Laura M. Johnson, Hannah E. Myers, Andrew Reisner, Laura S. Blackwell
IntroductionSocial determinants of health (SDH) are factors that may impact outcomes following pediatric traumatic brain injuries (TBI). The purpose of this study was to investigate the relationship between race and functional outcomes in a diverse pediatric population. We further explored how this association may be modified by SDH factors, including insurance status, social vulnerability, and child
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Myelin oligodendrocyte glycoprotein antibody titers by fixed cell-based assay: positive predictive value and impact of sample collection timing Front. Neurol. (IF 3.4) Pub Date : 2024-03-14 Adrian Budhram, Dalia L. Rotstein, Liju Yang, E. Ann Yeh
IntroductionIn January 2023, our laboratory began performing serum myelin oligodendrocyte glycoprotein antibody (anti-MOG) titers by fixed cell-based assay (CBA). As a quality assurance (QA) assessment, we evaluated titer positive predictive value (PPV) as well as impact of sample collection timing on titers.MethodsAmong patients who underwent antibody titers to distinguish between low-positive (<1:100)
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Exploring brain network oscillations during seizures in drug-naïve patients with juvenile absence epilepsy Front. Neurol. (IF 3.4) Pub Date : 2024-03-14 Linjie Tan, Haoling Tang, Hua Luo, Xiu Chen, Zhong Zheng, Jianghai Ruan, Dechou Zhang
ObjectiveWe aimed to investigate the brain network activity during seizures in patients with untreated juvenile absence epilepsy.MethodsThirty-six juvenile absence epilepsy (JAE) patients with a current high frequency of seizures (more than five seizures during a 2 h EEG examination) were included. Each participant underwent a 2 h video EEG examination. Five 10 s EEG epochs for inter-ictal, pre-ictal
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Suppression head impulse test in children—experiences in a tertiary paediatric vestibular centre Front. Neurol. (IF 3.4) Pub Date : 2024-03-14 Soumit Dasgupta, Rosa Crunkhorn, John Wong, Annie McMahon, Sudhira Ratnayake, Leonardo Manzari
The suppression head impulse paradigm (SHIMP) involves suppression of the vestibulo-ocular reflex (VOR) and anticompensatory saccades generated thereof. SHIMP is gaining importance to understand vestibular compensation with its different parameters (VOR gain/peak saccadic velocity PSV/latency of saccades). SHIMP studies are emerging in adults, but pediatric studies have hardly been performed. This
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Peripheral T cell immune repertoire is associated with the outcomes of acute spontaneous intracerebral hemorrhage Front. Neurol. (IF 3.4) Pub Date : 2024-03-14 Rui Zhang, Li Wang, Jiapo Zhang, Xiufang Zhang, Peng Wang
Systematic immune responses have been identified in patients with acute spontaneous intracerebral hemorrhage (ICH). T cells have been established to participate in central nervous system damage and repair following brain injury. However, their contribution to the prognosis of patients with ICH remains to be elucidated. In this study, peripheral blood mononuclear cells (PBMCs) were collected from 45
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Risk factors and outcomes after interruption of sedation in subarachnoid hemorrhage (ROUTINE-SAH)—a retrospective cohort study Front. Neurol. (IF 3.4) Pub Date : 2024-03-13 Moritz L. Schmidbauer, Sebastian Läufer, Andreas Maskos, Konstantinos Dimitriadis
IntroductionAneurysmal subarachnoid hemorrhage (aSAH) often necessitates prolonged sedation to manage elevated intracranial pressure (ICP) and to prevent secondary brain injury. Optimal timing and biomarkers for predicting adverse events (AEs) during interruption of sedation (IS) after prolonged sedation are not well established. To guide sedation management in aSAH, we aimed to explore the frequency
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Hyperbaric oxygen therapy for thalamic pain syndrome: case report Front. Neurol. (IF 3.4) Pub Date : 2024-03-13 John Benjamin Slade, Nathan Kwan, Peter Lennox, Russell Gray
Thalamic pain syndrome is a distressing type of central post-stroke pain (CPSP) that occurs in up to 10% of cases following a cerebrovascular accident, typically with a delayed onset of signs and symptoms, and is often chronic or even life-long. Thalamic pain syndrome, as is the case for other CPSPs, is difficult to treat, and the response is typically moderate at best. Central pain also occurs after
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A clinical-radiomics combined model based on carotid atherosclerotic plaque for prediction of ischemic stroke Front. Neurol. (IF 3.4) Pub Date : 2024-03-13 Na Han, Wanjun Hu, Yurong Ma, Yu Zheng, Songhong Yue, Laiyang Ma, Jie Li, Jing Zhang
ObjectivesTo accurately predict the risk of ischemic stroke, we established a radiomics model of carotid atherosclerotic plaque-based high-resolution vessel wall magnetic resonance imaging (HR-VWMRI) and combined it with clinical indicators.Materials and methodsIn total, 127 patients were finally enrolled and randomly divided into training and test cohorts. HR-VWMRI three-dimensional T1-weighted imaging
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Do people with ME/CFS and joint hypermobility represent a disease subgroup? An analysis using registry data Front. Neurol. (IF 3.4) Pub Date : 2024-03-13 Kathleen Mudie, Allison Ramiller, Sadie Whittaker, Leslie E. Phillips
BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally. Despite its significant impact, the disease's etiology remains poorly understood, and symptom heterogeneity poses challenges for diagnosis and treatment. Joint hypermobility, commonly seen in hypermobile Ehlers-Danlos Syndrome (hEDS), has been observed in ME/CFS patients
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Overlapping and distinct phenotypic profiles in Alzheimer’s disease and late onset epilepsy: a biologically-based approach Front. Neurol. (IF 3.4) Pub Date : 2024-03-13 Anli A. Liu, William B. Barr
Due to shared hippocampal dysfunction, patients with Alzheimer’s dementia and late-onset epilepsy (LOE) report memory decline. Multiple studies have described the epidemiological, pathological, neurophysiological, and behavioral overlap between Alzheimer’s Disease and LOE, implying a bi-directional relationship. We describe the neurobiological decline occurring at different spatial in AD and LOE patients
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Bickerstaff encephalitis in childhood: a review of 74 cases in the literature from 1951 to today Front. Neurol. (IF 3.4) Pub Date : 2024-03-12 Luca Gregorio Giaccari, Donatella Mastria, Rosella Barbieri, Rossella De Maglio, Francesca Madaro, Gianfranco Paiano, Maria Caterina Pace, Pasquale Sansone, Giuseppe Pulito, Luciana Mascia
Bickerstaff brainstem encephalitis (BBE) is a rare autoimmune disease characterized by the subacute onset of bilateral external ophthalmoplegia, ataxia, and decreased level of consciousness. BBE is part of a group of rare autoimmune diseases in children that can affect the nervous system at any level. The onset of neurological deficits is often sudden and nonspecific. The diagnosis is based on clinical
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Effects of online tDCS and hf-tRNS on reading performance in children and adolescents with developmental dyslexia: a study protocol for a cross sectional, within-subject, randomized, double-blind, and sham-controlled trial Front. Neurol. (IF 3.4) Pub Date : 2024-03-12 Andrea Battisti, Giulia Lazzaro, Cristiana Varuzza, Stefano Vicari, Deny Menghini
BackgroundDevelopmental Dyslexia (DD) is a brain-based developmental disorder causing severe reading difficulties. The extensive data on the neurobiology of DD have increased interest in brain-directed approaches, such as transcranial direct current stimulation (tDCS), which have been proposed for DD. While positive outcomes have been observed, results remain heterogeneous. Various methodological approaches
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Adrenal insufficiency following cerebellar intracranial hemorrhage: a case report Front. Neurol. (IF 3.4) Pub Date : 2024-03-12 Yu-Yang Lu, Chien-Ming Lin, Shang-Lin Chiang
This report presents a case of a previously healthy 58 years-old man who had suffered from persistent weakness and dizziness after a cerebellar intracranial hemorrhage (ICH). Endocrine function tests revealed low levels of plasma cortisol (3.05 μg/dL; normal range: 5–25 μg/dL) and adrenocorticotropic hormone (ACTH) (6.0 pg/mL; normal range: 10–60 pg/mL). The subsequent ACTH stimulation test suggested
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Association between SpO2 and the risk of death in elderly T2DM patients with cerebral infarction: a retrospective cohort study Front. Neurol. (IF 3.4) Pub Date : 2024-03-12 Shuo Zhang, Jiaqi Ji, Siqi Gao, Shu Yang, Zeyi Song, Jianmin Li, Junjie Liu
ObjectiveThis study aimed to evaluate the SpO2 (transcutaneous oxygen saturation) -mortality link in elderly T2DM (diabetes mellitus type 2) patients with cerebral infarction and identify their optimal SpO2 range.MethodsIn this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific
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Mnemonic utilization in stroke education: FAST and BEFAST adoption by certified comprehensive stroke centers Front. Neurol. (IF 3.4) Pub Date : 2024-03-12 Christopher Hogge, Larry B. Goldstein, Sushanth R. Aroor
IntroductionSymptom recognition and timely access to treatment are critical components of acute stroke care systems. Two mnemonics widely used in public educational campaigns for recognizing stroke symptoms include FAST (Face-Arm-Speech-Time) and BEFAST (Balance-Eyes-Face-Arm Speech-Time). The FAST mnemonic can miss up to 14% of strokes. BEFAST includes common posterior circulation stroke symptoms
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Psychometric evaluation and reference values for the German Postconcussion Symptom Inventory (PCSI-SR8) in children aged 8–12 years Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Marina Zeldovich, Leonie Krol, Dagmar Timmermann, Ugne Krenz, Juan Carlos Arango-Lasprilla, Gerard Gioia, Knut Brockmann, Inga K. Koerte, Anna Buchheim, Maike Roediger, Matthias Kieslich, Nicole von Steinbuechel, Katrin Cunitz
BackgroundPost-concussion symptoms (PCS) are a common consequence of pediatric traumatic brain injury (pTBI). They include cognitive, emotional, and physical disturbances. To address the lack of age-adapted instruments assessing PCS after pTBI, this study examines the psychometric properties of the German 17-item post-TBI version of the Postconcussion Symptom Inventory (PCSI-SR8) in children aged 8–12
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Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Bangjie Xu, Jiangbin Ren, Siqi Zhu, Yu Ding, Wei Zhou, Qing Guo, Yan Fang, Jing Zheng
BackgroundTelomere length is closely linked to the aging phenotype, where cellular aging results in the production of a cascade of cell factors and the senescence-associated secretory phenotype (SASP), leading to an inflammatory response. The presence of inflammation plays a crucial role in the formation of intracranial aneurysms. Nevertheless, the relationship between telomere length and intracranial
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Endovascular treatment of distal anterior cerebral artery aneurysms using flow modulation devices: mid- and long-term results from a two-center study Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Ali Khanafer, Hans Henkes, Jose Cohen, Pablo Albiña-Palmarola, John Moshe Gomori, Michael Forsting, Philipp von Gottberg
PurposeFlow-diverter (FD) stents have become an established treatment for intracranial aneurysms in recent years, but their use for aneurysms in distal cerebral vessels with small carrier vessel diameters remains controversial. This study describes the method and mid- and long-term outcomes of FD treatment of distal anterior cerebral artery aneurysms (DACAAs) at two neurointerventional centers, to
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Treatment strategies and treatment-related adverse events in MG according to the age of onset Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 João Moura, Joana Fernandes, Maria João Lima, Ana Paula Sousa, Raquel Samões, Ana Martins Silva, Ernestina Santos
IntroductionEarly-onset (EOMG) and late-onset (LOMG) are distinct groups of MG patients. It is unclear if treatment strategies and treatment-related adverse events may differ according to the age of MG onset.MethodsThis single-center retrospective study includes all MG patients followed at a tertiary center since 2007. We reviewed the electronic clinical records.ResultsIn total, 212 patients were identified
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Probable secondary hemophagocytic lymphohistiocytosis manifesting as central nervous system lesions after COVID-19 vaccination: a case report Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Ju Hye Kim, Ji Yeon Chung, Jeong Bin Bong
BackgroundHemophagocytic lymphohistiocytosis (HLH) is a rare systemic inflammatory disease commonly characterized by histiocyte infiltration in multiple organs, such as the liver, spleen, lymph nodes, bone marrow, and central nervous system. The clinical features of HLH include fever, splenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and elevated blood ferritin levels. HLH is categorized
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Cervical impairments in subjects with migraine or tension type headache: an observational study Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Jose Ángel del Blanco Muñiz, Alberto Sánchez Sierra, Arturo Ladriñán Maestro, Roberto Ucero Lozano, María Dolores Sosa-Reina, Daniel Martín Vera
ObjectiveThe aim of this investigation was to compare the thickness of the deep local muscles in the neck region, as well as local and widespread sensitivity and functionality, between individuals with migraine, Tension-Type Headache (TTH), and healthy controls. To date, we know that the onset of migraine and TTH share similar pathophysiological pathways. Nevertheless, there may be some anatomical
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Age and duration of hypertension are associated with carotid artery tortuosity Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Huan Huang, Jian-Jiong Fu, Pi-Guang Yao, Meng-Yao Wang, Xue Wang, An-Na Guo, Wei Li, Shao-Huai Chen, Dan-Dong Li
ObjectiveTortuosity of the carotid artery is a common angiographic finding that may impact blood flow and neuronal function. However, information on its prevalence and risk factors remains limited. In this study, we determined to explore the factors affecting carotid artery tortuosity.MethodsThe head and neck computed tomography angiography (CTA) imaging and cerebral angiography data performed at the
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Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Jannis Wißfeld, Tawfik Abou Assale, German Cuevas-Rios, Huan Liao, Harald Neumann
Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the central nervous system (CNS). Sialic acid-binding immunoglobulin-like lectins (SIGLECs) expressed on microglia are key players in maintaining microglial homeostasis by recognizing intact sialylation. The finely balanced
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Epilepsy-related functional brain network alterations are already present at an early age in the GAERS rat model of genetic absence epilepsy Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Lydia Wachsmuth, Leo Hebbelmann, Jutta Prade, Laura C. Kohnert, Henriette Lambers, Annika Lüttjohann, Thomas Budde, Andreas Hess, Cornelius Faber
IntroductionGenetic Absence Epilepsy Rats from Strasbourg (GAERS) represent a model of genetic generalized epilepsy. The present longitudinal study in GAERS and age-matched non-epileptic controls (NEC) aimed to characterize the epileptic brain network using two functional measures, resting state-functional magnetic resonance imaging (rs-fMRI) and manganese-enhanced MRI (MEMRI) combined with morphometry
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Clinical presentation and diagnosis of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: a literature analysis of case studies Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Spyros Papapetropoulos, Jeffrey M. Gelfand, Takuya Konno, Takeshi Ikeuchi, Angela Pontius, Andreas Meier, Farid Foroutan, Zbigniew K. Wszolek
IntroductionBecause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, rapidly progressive, debilitating, and ultimately fatal neurodegenerative disease, a rapid and accurate diagnosis is critical. This analysis examined the frequency of initial misdiagnosis of ALSP via comprehensive review of peer-reviewed published cases.MethodsData were extracted from a MEDLINE
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Disease-modifying therapy in progressive multiple sclerosis: a systematic review and network meta-analysis of randomized controlled trials Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Xin Wu, Shixin Wang, Tao Xue, Xin Tan, Jiaxuan Li, Zhouqing Chen, Zhong Wang
BackgroundCurrently, disease-modifying therapies (DMTs) for progressive multiple sclerosis (PMS) are widely used in clinical practice. At the same time, there are a variety of drug options for DMTs, but the effect of the drugs that can better relieve symptoms and improve the prognosis are still inconclusive.ObjectivesThis systematic review aimed to evaluate the efficacy and safety of DMTs for PMS and
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Therapeutic outcome of patients with Lennox–Gastaut syndrome with mitochondrial respiratory chain complex I deficiency Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Ji-Hoon Na, Young-Mock Lee
BackgroundLennox–Gastaut syndrome (LGS), a severe developmental epileptic encephalopathy, has various underlying causes. Mitochondrial respiratory chain complex I (MRC I) deficiency is an important cause of metabolic disorders such as mitochondrial dysfunction that can compromise brain function, thereby causing intractable epilepsy, including LGS. Thus, it can be expected that the presence or absence
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Advancements in autologous peripheral nerve transplantation care: a review of strategies and practices to facilitate recovery Front. Neurol. (IF 3.4) Pub Date : 2024-03-11 Guoying Xu, Xiaodi Zou, Yanzhao Dong, Ahmad Alhaskawi, Haiying Zhou, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Olga Alenikova, Sahar Ahmed Abdalbary, Hui Lu
Autologous peripheral nerve transplantation, a pioneering technique in nerve injury treatment, has demonstrated remarkable progress. We examine recent nursing strategies and methodologies tailored to various anatomical sites, highlighting their role in postoperative recovery enhancement. Encompassing brachial plexus, upper limb, and lower limb nerve transplantation care, this discussion underscores
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Frontiers | Relationship between sodium level and in-hospital mortality in traumatic brain injury patients of MIMIC IV database Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Xiaoliang Wang, Xin Li, Jiahao Sun, Mengmeng Wang, Wenjuan Lang, Xin Xu
Background An association between prognosis and high sodium levels in Traumatic Brain Injury (TBI) patients in Intensive Care Units (ICUs) has been noted, but limited research exists on the ideal sodium level in these patients or the impact on early mortality, using the MIMIC-IV database. Methods A retrospective survey was conducted on TBI patients from the MIMIC-IV database. Patients were divided
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Using the gross motor function measure evolution ratio to compare different dosage of hyperbaric treatment with conventional therapies in children with cerebral palsy – could it end the controversy? Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Pierre Marois, Guy Letellier, Mikaël Marois, Laurent Ballaz
The Gross Motor Function Measure is used in most studies measuring gross motor function in children with cerebral palsy. In many studies, including those evaluating the effect of hyperbaric treatment, the Gross Motor Function Measure variations were potentially misinterpreted because of the lack of control groups. The Gross Motor Function Measure Evolution Ratio (GMFMER) uses historical data from the
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Mapping knowledge of the stem cell in traumatic brain injury: a bibliometric and visualized analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Tingzhen Deng, Ruiwen Ding, Yatao Wang, Yueyang Chen, Hongtao Sun, Maohua Zheng
BackgroundTraumatic brain injury (TBI) is a brain function injury caused by external mechanical injury. Primary and secondary injuries cause neurological deficits that mature brain tissue cannot repair itself. Stem cells can self-renewal and differentiate, the research of stem cells in the pathogenesis and treatment of TBI has made significant progress in recent years. However, numerous articles must
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The effect of argatroban on early neurological deterioration and outcomes in minor ischemic stroke: preliminary findings Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Xuehong Jin, Xia Li, Hong Zhang, Xiaohan Yao, Yongquan Gu, Shaofang Pei, Lan Hu
BackgroundMinor ischemic stroke (MIS) is associated with early neurological deterioration (END) and poor prognosis. Here, we investigated whether argatroban administration can mitigate MIS-associated END and improve functional outcomes by monitoring activated partial thrombin time (APTT).MethodsData were collected for patients with MIS admitted to our hospital from January 2019 to December 2022. Patients
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Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Emmanuel J. Jáuregui, Kelli L. Scheinman, Ingrid K. Bibriesca Mejia, Lindsay Pruett, Hannah Zaini, Connor Finkbeiner, Jonathan A. Phillips, Jay A. Gantz, Tot Bui Nguyen, James O. Phillips, Jennifer S. Stone
Vestibular hair cells (HCs) are mechanoreceptors that sense head motions by modulating the firing rate of vestibular ganglion neurons (VGNs), whose central processes project to vestibular nucleus neurons (VNNs) and cerebellar neurons. We explored vestibular function after HC destruction in adult Pou4f3+/DTR (DTR) mice, in which injections of high-dose (50 ng/g) diphtheria toxin (DT) destroyed most
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Eptinezumab for the preventive treatment of episodic and chronic migraine: a narrative review Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Pablo Irimia, Sonia Santos-Lasaosa, Patricia Pozo-Rosich, Rogelio Leira, Julio Pascual, José Miguel Láinez
Eptinezumab, a monoclonal antibody that targets calcitonin gene-related peptide (CGRP), was recently approved in Europe for the prophylactic treatment of migraine in adults who have at least four migraine days a month. Eptinezumab is administered by intravenous infusion every 12 weeks. During recent months, a considerable amount of evidence from eptinezumab trials has been published. The aim of this
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Analyzing the causal relationship between lipid-lowering drug target genes and epilepsy: a Mendelian randomization study Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Shicun Huang, Yuan Liu, Yi Zhang, Yiqing Wang, Ya Gao, Runnan Li, Lidong Yu, Xiaowei Hu, Qi Fang
BackgroundPrevious research has yielded conflicting results on the link between epilepsy risk and lipid-lowering medications. The aim of this study is to determine whether the risk of epilepsy outcomes is causally related to lipid-lowering medications predicted by genetics.MethodsWe used genetic instruments as proxies to the exposure of lipid-lowering drugs, employing variants within or near genes
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The effects of Tai Chi exercise on sleep quality among the elderly: a study based on polysomnographic monitoring Front. Neurol. (IF 3.4) Pub Date : 2024-03-08 Chao Wang, Tao Jiang, Hansen Li, Guikang Cao, Guodong Zhang
BackgroundSleep disorders contribute to an increased risk of depression, cardiovascular issues, and various other diseases among older individuals. Consequently, enhancing the sleep quality of this demographic population has become a pressing concern. The objective of this study was to investigate the influence of an 8-week Tai Chi exercise intervention in the sleep quality of older adults.MethodsSixty
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Fear of disease in patients with epilepsy – a network analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-07 Xiaoxiao Yin, Shan Niu, Qun Yu, Yejing Xuan, Xiuqin Feng
BackgroundDisease-related fear among patients with epilepsy has significantly impacted their quality of life. The Disease-Related Fear Scale (D-RFS), comprising three dimensions, serves as a relatively well-established tool for assessing fear in these patients. However, certain problems potentially exist within the D-RFS’s attribution of items, and its internal structure is still unclear. To establish
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Nomogram prediction model for the risk of intracranial hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke Front. Neurol. (IF 3.4) Pub Date : 2024-03-07 Yong Ma, Dong-Yan Xu, Qian Liu, He-Cheng Chen, Er-Qing Chai
BackgroundHemorrhagic transformation (HT) after intravenous thrombolysis (IVT) might worsen the clinical outcomes, and a reliable predictive system is needed to identify the risk of hemorrhagic transformation after IVT.MethodsRetrospective collection of patients with acute cerebral infarction treated with intravenous thrombolysis in our hospital from 2018 to 2022. 197 patients were included in the
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Complications of oropharyngeal dysphagia in older individuals and patients with neurological disorders: insights from Mataró hospital, Catalonia, Spain Front. Neurol. (IF 3.4) Pub Date : 2024-03-07 Tennekoon B. Karunaratne, Pere Clavé, Omar Ortega
BackgroundOropharyngeal dysphagia (OD) significantly impacts older individuals and neurologically compromised patients, hindering safe ingestion of food and liquids. Despite its prevalence, OD remains underdiagnosed and undertreated, leading to severe complications such as malnutrition, dehydration, respiratory infections, and aspiration pneumonia (AP), and increases hospital readmissions.ObjectivesThis
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The changing landscape of palliative epilepsy surgery for Lennox Gastaut Syndrome Front. Neurol. (IF 3.4) Pub Date : 2024-03-07 Ruba Al-Ramadhani, Jasmine L. Hect, Taylor J. Abel
Lennox Gastaut Syndrome (LGS) is characterized by drug-resistant epilepsy that typically leads to decreased quality of life and deleterious neurodevelopmental comorbidities from medically refractory seizures. In recent years there has been a dramatic increase in the development and availability of novel treatment strategies for Lennox Gastaut Syndrome patient to improve seizure. Recent advances in
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Neurophysiological indices for split phenomena: correlation with age and sex and potential implications in amyotrophic lateral sclerosis Front. Neurol. (IF 3.4) Pub Date : 2024-03-07 Stefano Zoccolella, Giammarco Milella, Alessia Giugno, Vito Devitofrancesco, Rosaria Damato, Ludovica Tamburrino, Salvatore Misceo, Marco Filardi, Giancarlo Logroscino
BackgroundSplit phenomena (SP) are characterized by patterns of differential muscle wasting and atrophy, which are highly prevalent in amyotrophic lateral sclerosis (ALS) patients. Several neurophysiological indicators, including the split-hand index (SHI), split-leg index (SLI), and split-elbow index (SEI), have been proposed to assess SP. Nevertheless, their cutoff values and the impact of age and
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Risk factors for intracerebral hemorrhage in small-vessel disease and non-small-vessel disease etiologies—an observational proof-of-concept study Front. Neurol. (IF 3.4) Pub Date : 2024-03-07 Philipp Arndt, Christian Chahem, Michael Luchtmann, Jan-Niklas Kuschel, Daniel Behme, Malte Pfister, Jens Neumann, Michael Görtler, Marc Dörner, Marc Pawlitzki, Robin Jansen, Sven G. Meuth, Stefan Vielhaber, Solveig Henneicke, Stefanie Schreiber
BackgroundSporadic cerebral small-vessel disease (CSVD), i.e., hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA), is the main cause of spontaneous intracerebral hemorrhage (ICH). Nevertheless, a substantial portion of ICH cases arises from non-CSVD etiologies, such as trauma, vascular malformations, and brain tumors. While studies compared HA- and CAA-related ICH, non-CSVD etiologies
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Predicting postinterventional rupture of intracranial aneurysms using arteriography-derived radiomic features after pipeline embolization Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Chao Ma, Shikai Liang, Fei Liang, Ligong Lu, Haoyu Zhu, Xianli Lv, Xuejun Yang, Chuhan Jiang, Yupeng Zhang
Background and purposePostinterventional rupture of intracranial aneurysms (IAs) remains a severe complication after flow diverter treatment. However, potential hemodynamic mechanisms underlying independent predictors for postinterventional rupture of IAs remain unclear. In this study, we employed arteriography-derived radiomic features to predict this complication.MethodsWe included 64 patients who
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The efficacy and safety of novel antiepileptic drugs in treatment of epilepsy of patients with brain tumors Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Weiwei Zhai, Qiaoling Yu, Huizhen Wu
ObjectiveThis meta-analysis aimed to assess the effectiveness and safety of novel antiepileptic drugs (AEDs) in treating epilepsy in patients with brain tumors (BTRE).MethodsA search was conducted on PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to February 2023, with English language restriction.ResultsIn this meta-analysis, 18 clinical trials involving 755 BTRE patients
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Analyzing the bibliometrics of brain-gut axis and Parkinson’s disease Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Lingshan Chen, Jianfei Chen, Min Wu, Pingkang Yan, Xueping Zhou
BackgroundParkinson’s disease (PD), characterized by the loss of dopaminergic neurons, is a progressive neurodegenerative disorder. Recent research has revealed a significant connection between gut microbiota and PD. To gain insight into research interests, disciplinary contexts, and potential future directions, a comprehensive bibliometric analysis was conducted on the brain-gut axis and PD literature
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Habituation disorders in auditory middle latency response of persistent postural-perceptual dizziness patients Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Toshihisa Murofushi, Fumiyuki Goto, Munetaka Ushio
ObjectivesTo study habituation disorders in auditory middle latency response (AMLR) to repetitive stimuli of persistent postural-perceptual dizziness (PPPD) patients.SubjectsTwenty-eight PPPD (10 men and 18 women, mean 59.5 years of age, 26–81 years of age) were enrolled. For comparison, data of 13 definite vestibular migraine (VM) patients (3 men, 10 women, mean age 45.5), 13 definite unilateral Meniere’s
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Delipid extracorporeal lipoprotein filter from plasma system: a new intensive lipid lowering therapy for patients with acute ischemic stroke Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Yuqiong Jiao, Qi Yang, Ting Ye, Jun Zhu, Qunyi Li, Xiang Han, Qiang Dong
ObjectivesTo investigate the safety and efficacy of the delipid extracorporeal lipoprotein filter from plasma (DELP) system, a new low-density lipoprotein cholesterol (LDL-C) adsorption system, in acute ischemic stroke (AIS) patients.Patients and methodsIn the present study, a total of 180 AIS patients were enrolled during March 2019 to February 2021. They were divided into DELP group (n1 = 90) and
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The role of microRNAs in axon regeneration after peripheral nerve injury: a bibliometric analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Kutiluke Shoukeer, Shalayiding Aierxiding, Aikebaierjiang Aisaiti, Abuduwupuer Haibier, Chunhua Liu, Zhiwei Jia, Abudunaibi Aili, Li Shu, Kan Jiang, Aikeremujiang Muheremu
ObjectiveThis study analyzed the current research hotspots and future development trends of the therapeutic effects of microRNA on PNI axonal regeneration through bibliometric methods. Moreover, the current advantages and disadvantages of this field as well as future development prospects are discussed in depth.MethodsCiteSpace V and VOSviewer were used as bibliometric tools to complete the analysis
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Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease Front. Neurol. (IF 3.4) Pub Date : 2024-03-06 Mihály Hajós, Alyssa Boasso, Evan Hempel, Monika Shpokayte, Alex Konisky, Chandran V. Seshagiri, Vitella Fomenko, Kim Kwan, Jessie Nicodemus-Johnson, Suzanne Hendrix, Brent Vaughan, Ralph Kern, Jonathan T. Megerian, Zach Malchano
BackgroundAlzheimer’s Disease (AD) is a multifactorial, progressive neurodegenerative disease that disrupts synaptic and neuronal activity and network oscillations. It is characterized by neuronal loss, brain atrophy and a decline in cognitive and functional abilities. Cognito’s Evoked Gamma Therapy System provides an innovative approach for AD by inducing EEG-verified gamma oscillations through sensory
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Frontiers | Exploring the role of in-patient magnetic resonance imaging use among admitted ischemic stroke patients in improving patient outcomes and reducing healthcare resource utilization Front. Neurol. (IF 3.4) Pub Date : 2024-03-05 Mukesh Kumar, Steven Beyea, Sherry Hu, Noreen Kamal
Purpose Despite the diagnostic and etiological significance of in-patient MRI in ischemic stroke (IS), its utilization is considered resource-intensive, expensive, and thus limiting feasibility and relevance. This study investigated the utilization of in-patient MRI for IS patients and its impact on patient and healthcare resource utilization outcomes. Methods This retrospective registry-based study
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Small and large fiber neuropathy in adults with myotonic dystrophy type 1 Front. Neurol. (IF 3.4) Pub Date : 2024-03-05 Gro Solbakken, Sissel Løseth, Jan C. Frich, Espen Dietrichs, Kristin Ørstavik
IntroductionMyotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder that affects multiple organs. In this study, we investigated symptoms of pain and presence of small and large fiber neuropathy in the juvenile and adult form of DM1.MethodTwenty genetically verified DM1 patients were included. Pain was assessed, and neurological examination and investigations of the peripheral nervous
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In-hospital stroke protocol outcomes before and after the implementation of neurological assessments by telemedicine: an observational case–control study Front. Neurol. (IF 3.4) Pub Date : 2024-03-05 Rodrigo Meirelles Massaud, Tarso Augusto Duenhas Accorsi, Cristina Gonçalves Massant, Gisele Sampaio Silva, Anna Verena de Carvalho Leite, Marcelo Franken, Flavio Tocci Moreira, Karen Francine Köhler, Karine De Amicis Lima, Renata Albaladejo Morbeck, Carlos Henrique Sartorato Pedrotti
PurposeStroke is the second leading cause of global adult mortality and the primary cause of disability. A rapid assessment by a neurologist for general and reperfusion treatments in ischemic strokes is linked to decreased mortality and disability. Telestroke assessment is a strategy that allows for neurological consultations with experienced professionals, even in remote emergency contexts. No randomized