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Explainable machine learning radiomics model for Primary Progressive Aphasia classification Front. Syst. Neurosci. (IF 3.0) Pub Date : 2024-02-26 Benedetta Tafuri, Roberto De Blasi, Salvatore Nigro, Giancarlo Logroscino
Introduction Primary Progressive Aphasia (PPA) is a neurodegenerative disease characterized by linguistic impairment. The two main clinical subtypes are semantic (svPPA) and non-fluent/agrammatic (nfvPPA) variants. Diagnosing and classifying PPA patients represents a complex challenge that requires the integration of multimodal information, including clinical, biological, and radiological features
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Updating perspectives on spinal cord function: motor coordination, timing, relational processing, and memory below the brain Front. Syst. Neurosci. (IF 3.0) Pub Date : 2024-02-20 James W. Grau, Kelsey E. Hudson, David T. Johnston, Sienna R. Partipilo
Those studying neural systems within the brain have historically assumed that lower-level processes in the spinal cord act in a mechanical manner, to relay afferent signals and execute motor commands. From this view, abstracting temporal and environmental relations is the province of the brain. Here we review work conducted over the last 50 years that challenges this perspective, demonstrating that
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First activity and interactions in thalamus and cortex using raw single-trial EEG and MEG elicited by somatosensory stimulation Front. Syst. Neurosci. (IF 3.0) Pub Date : 2024-01-05 Christodoulos Karittevlis, Michail Papadopoulos, Vinicius Lima, Gregoris A. Orphanides, Shubham Tiwari, Marios Antonakakis, Vicky Papadopoulou Lesta, Andreas A. Ioannides
IntroductionOne of the primary motivations for studying the human brain is to comprehend how external sensory input is processed and ultimately perceived by the brain. A good understanding of these processes can promote the identification of biomarkers for the diagnosis of various neurological disorders; it can also provide ways of evaluating therapeutic techniques. In this work, we seek the minimal
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Pointing in cervical dystonia patients Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-11-28 Maria Paola Tramonti Fantozzi, Roberta Benedetti, Alessandra Crecchi, Lucia Briscese, Paolo Andre, Pieranna Arrighi, Luca Bonfiglio, Maria Chiara Carboncini, Luca Bruschini, Paolo Bongioanni, Ugo Faraguna, Diego Manzoni
IntroductionThe normal hemispheric balance can be altered by the asymmetric sensorimotor signal elicited by Cervical Dystonia (CD), leading to motor and cognitive deficits.MethodsDirectional errors, peak velocities, movement and reaction times of pointing towards out-of-reach targets in the horizontal plane were analysed in 18 CD patients and in 11 aged-matched healthy controls.ResultsCD patients displayed
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Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-11-23 Sabina Couto-Ovejero, Jingjing Ye, Peter C. Kind, Sally M. Till, Thomas C. Watson
Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to non-motor realms, such as fear-based emotional processing and that these functions are supported by interactions with a wide range of brain structures. Research related to the cerebellar contributions to emotional processing has focussed primarily
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Oculomotor feature discrimination is cortically mediated Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-10-12 Devin H. Kehoe, Mazyar Fallah
Eye movements are often directed toward stimuli with specific features. Decades of neurophysiological research has determined that this behavior is subserved by a feature-reweighting of the neural activation encoding potential eye movements. Despite the considerable body of research examining feature-based target selection, no comprehensive theoretical account of the feature-reweighting mechanism has
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How far neuroscience is from understanding brains Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-10-05 Per E. Roland
The cellular biology of brains is relatively well-understood, but neuroscientists have not yet generated a theory explaining how brains work. Explanations of how neurons collectively operate to produce what brains can do are tentative and incomplete. Without prior assumptions about the brain mechanisms, I attempt here to identify major obstacles to progress in neuroscientific understanding of brains
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Editorial: Brain connectivity in neurological disorders. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-09-26 Alessandro Salvalaggio,Lorenzo Pini,Alessandra Griffa,Maurizio Corbetta
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Multiple regions of sensorimotor cortex encode bite force and gape Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-09-22 Fritzie I. Arce-McShane, Barry J. Sessle, Yasheshvini Ram, Callum F. Ross, Nicholas G. Hatsopoulos
The precise control of bite force and gape is vital for safe and effective breakdown and manipulation of food inside the oral cavity during feeding. Yet, the role of the orofacial sensorimotor cortex (OSMcx) in the control of bite force and gape is still largely unknown. The aim of this study was to elucidate how individual neurons and populations of neurons in multiple regions of OSMcx differentially
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Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-09-07 Ellen Boven, Nadia L. Cerminara
Performing successful adaptive behaviour relies on our ability to process a wide range of temporal intervals with certain precision. Studies on the role of the cerebellum in temporal information processing have adopted the dogma that the cerebellum is involved in sub-second processing. However, emerging evidence shows that the cerebellum might be involved in suprasecond temporal processing as well
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Beyond rhythm – a framework for understanding the frequency spectrum of neural activity Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-31 Quentin Perrenoud, Jessica A. Cardin
Cognitive and behavioral processes are often accompanied by changes within well-defined frequency bands of the local field potential (LFP i.e., the voltage induced by neuronal activity). These changes are detectable in the frequency domain using the Fourier transform and are often interpreted as neuronal oscillations. However, aside some well-known exceptions, the processes underlying such changes
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Differential optogenetic activation of the auditory midbrain in freely moving behaving mice Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-31 Meike M. Rogalla, Adina Seibert, Jana M. Sleeboom, K. Jannis Hildebrandt
IntroductionIn patients with severe auditory impairment, partial hearing restoration can be achieved by sensory prostheses for the electrical stimulation of the central nervous system. However, these state-of-the-art approaches suffer from limited spectral resolution: electrical field spread depends on the impedance of the surrounding medium, impeding spatially focused electrical stimulation in neural
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The perceptual consequences and neurophysiology of eye blinks Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-17 Shawn M. Willett, Sarah K. Maenner, J. Patrick Mayo
A hand passing in front of a camera produces a large and obvious disruption of a video. Yet the closure of the eyelid during a blink, which lasts for hundreds of milliseconds and occurs thousands of times per day, typically goes unnoticed. What are the neural mechanisms that mediate our uninterrupted visual experience despite frequent occlusion of the eyes? Here, we review the existing literature on
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Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-14 Patricia Gil-Paterna, Tomas Furmark
Post-traumatic stress disorder (PTSD) and anxiety disorders are among the most prevalent psychiatric conditions worldwide sharing many clinical manifestations and, most likely, neural mechanisms as suggested by neuroimaging research. While the so-called fear circuitry and traditional limbic structures of the brain, particularly the amygdala, have been extensively studied in sufferers of these disorders
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From signals to music: a bottom-up approach to the structure of neuronal activity Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-11 Gabriel D. Noel, Lionel E. Mugno, Daniela S. Andres
IntroductionThe search for the “neural code” has been a fundamental quest in neuroscience, concerned with the way neurons and neuronal systems process and transmit information. However, the term “code” has been mostly used as a metaphor, seldom acknowledging the formal definitions introduced by information theory, and the contributions of linguistics and semiotics not at all. The heuristic potential
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Basal ganglia for beginners: the basic concepts you need to know and their role in movement control Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-03 Gabriel S. Rocha, Marco A. M. Freire, André M. Britto, Karina M. Paiva, Rodrigo F. Oliveira, Ivana A. T. Fonseca, Dayane P. Araújo, Lucidio C. Oliveira, Fausto P. Guzen, Paulo L. A. G. Morais, José R. L. P. Cavalcanti
The basal ganglia are a subcortical collection of interacting clusters of cell bodies, and are involved in reward, emotional, and motor circuits. Within all the brain processing necessary to carry out voluntary movement, the basal nuclei are fundamental, as they modulate the activity of the motor regions of the cortex. Despite being much studied, the motor circuit of the basal ganglia is still difficult
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Alterations of PAC-based resting state networks in Parkinson’s disease are partially alleviated by levodopa medication Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-08-01 Sean Mertiens, Matthias Sure, Alfons Schnitzler, Esther Florin
IntroductionParkinson’s disease (PD) is a neurodegenerative disorder affecting the whole brain, leading to several motor and non-motor symptoms. In the past, it has been shown that PD alters resting state networks (RSN) in the brain. These networks are usually derived from fMRI BOLD signals. This study investigated RSN changes in PD patients based on maximum phase-amplitude coupling (PAC) throughout
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Editorial: Neuromodulation by digital and analog drugs in consciousness research. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-27 Darren F Hight,Anthony G Hudetz,Axel Hutt
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Neurocognitive and cerebellar function in ADHD, autism and spinocerebellar ataxia Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-21 Maurizio Cundari, Susanna Vestberg, Peik Gustafsson, Sorina Gorcenco, Anders Rasmussen
The cerebellum plays a major role in balance, motor control and sensorimotor integration, but also in cognition, language, and emotional regulation. Several neuropsychiatric disorders such as attention deficit-hyperactivity disorder (ADHD), autism spectrum disorder (ASD), as well as neurological diseases such as spinocerebellar ataxia type 3 (SCA3) are associated with differences in cerebellar function
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Editorial: The role of brain oscillatory activity in human sensorimotor control and learning: bridging theory and practice. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-20 Elisa Tatti,Alberto Cacciola
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FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-19 Jason R. Gerstner, Carlos C. Flores, Micah Lefton, Brooke Rogers, Christopher J. Davis
Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are largely focused on neuronal cells. Research on these topics has traditionally segregated sleep homeostatic behavior from circadian rest-activity rhythms
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Diversity of electroencephalographic patterns during propofol-induced burst suppression Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-15 Keith G. Jones, Carter Lybbert, Matthew J. Euler, Jason Huang, Seth Lunt, Sindhu V. Richards, Jacob E. Jessop, Adam Larson, David H. Odell, Kai Kuck, Scott C. Tadler, Brian J. Mickey
Burst suppression is a brain state consisting of high-amplitude electrical activity alternating with periods of quieter suppression that can be brought about by disease or by certain anesthetics. Although burst suppression has been studied for decades, few studies have investigated the diverse manifestations of this state within and between human subjects. As part of a clinical trial examining the
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Higher prefrontal activity based on short-term neurofeedback training can prevent working memory decline in acute stroke Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-14 Masayuki Tetsuka, Takeshi Sakurada, Mayuko Matsumoto, Takeshi Nakajima, Mitsuya Morita, Shigeru Fujimoto, Kensuke Kawai
This study aimed to clarify whether short-term neurofeedback training during the acute stroke phase led to prefrontal activity self-regulation, providing positive efficacy to working memory. A total of 30 patients with acute stroke performed functional near-infrared spectroscopy-based neurofeedback training for a day to increase their prefrontal activity. A randomized, Sham-controlled, double-blind
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Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-14 Ignasi Melchor-Eixea, Julian Guarque-Chabrera, Aitor Sanchez-Hernandez, Patricia Ibáñez-Marín, Raúl Pastor, Marta Miquel
Substance Use Disorder (SUD) involves emotional, cognitive, and motivational dysfunction. Long-lasting molecular and structural changes in brain regions functionally and anatomically linked to the cerebellum, such as the prefrontal cortex, amygdala, hippocampus, basal ganglia, and ventral tegmental area, are characteristic of SUD. Direct and indirect reciprocal connectivity between the cerebellum and
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Editorial: Broadening our conceptual understanding of endogenous opioids in systems neuroscience. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-13 Hugo A Tejeda,Nicolas Massaly,Gregory Corder,Catherine M Cahill
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A sensory signal related to left-right symmetry modulates intra- and interlimb cutaneous reflexes during locomotion in intact cats Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-09 Stephen Mari, Charly G. Lecomte, Angèle N. Merlet, Johannie Audet, Jonathan Harnie, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon
IntroductionDuring locomotion, cutaneous reflexes play an essential role in rapidly responding to an external perturbation, for example, to prevent a fall when the foot contacts an obstacle. In cats and humans, cutaneous reflexes involve all four limbs and are task- and phase modulated to generate functionally appropriate whole-body responses.MethodsTo assess task-dependent modulation of cutaneous
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Extensive complex neocortical movement topography devolves to simple output following experimental stroke in mice Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-06-07 Cassandra C. Wolsh, Rogers Milton Brown, Andrew R. Brown, Gilbert Andrew Pratt, Jeffery Allen Boychuk
The neocortex encodes complex and simple motor outputs in all mammalian species that have been tested. Given that changes in neocortical reorganization (and corresponding corticospinal output) have been implicated in long term motor recovery after stroke injury, there remains a need to understand this biology in order to expedite and optimize clinical care. Here, changes in the neocortical topography
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Phylogenic evolution of beat perception and synchronization: a comparative neuroscience perspective Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-31 Jin-Kun Huang, Bin Yin
The study of music has long been of interest to researchers from various disciplines. Scholars have put forth numerous hypotheses regarding the evolution of music. With the rise of cross-species research on music cognition, researchers hope to gain a deeper understanding of the phylogenic evolution, behavioral manifestation, and physiological limitations of the biological ability behind music, known
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The contralateral organization of the human nervous system as a quantum unfolded, holographic-like, artifactual representation of the underlying dynamics of a fundamentally two-dimensional universe Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-31 Ronald L. Zukauskis
A working hypothesis is put forward in this article that the contralateral organization of the human nervous system appears to function like a quantum unfolded holographic apparatus by appearing to invert and reverse quantum unfolded visual and non-visual spatial information. As such, the three-dimensional contralateral organization would be an artifactual representation of the underlying dynamics
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A scoping review for building a criticality-based conceptual framework of altered states of consciousness Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-25 Charles Gervais, Louis-Philippe Boucher, Guillermo Martinez Villar, UnCheol Lee, Catherine Duclos
The healthy conscious brain is thought to operate near a critical state, reflecting optimal information processing and high susceptibility to external stimuli. Conversely, deviations from the critical state are hypothesized to give rise to altered states of consciousness (ASC). Measures of criticality could therefore be an effective way of establishing the conscious state of an individual. Furthermore
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Nucleus incertus provides eye velocity and position signals to the vestibulo-ocular cerebellum: a new perspective of the brainstem–cerebellum–hippocampus network Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-25 Guy Cheron, Laurence Ris, Ana Maria Cebolla
The network formed by the brainstem, cerebellum, and hippocampus occupies a central position to achieve navigation. Multiple physiological functions are implicated in this complex behavior. Among these, control of the eye–head and body movements is crucial. The gaze-holding system realized by the brainstem oculomotor neural integrator (ONI) situated in the nucleus prepositus hypoglossi and fine-tuned
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Modulation of cerebellar cortical, cerebellar nuclear and vestibular nuclear activity using alternating electric currents Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-18 Billur Avlar, Ramia Rahman, Sai Vendidandi, Esma Cetinkaya, Ahmet S. Asan, Mesut Sahin, Eric J. Lang
IntroductionCerebellar transcranial alternating current stimulation (ctACS) has shown promise as a therapeutic modality for treating a variety of neurological disorders, and for affecting normal learning processes. Yet, little is known about how electric fields induced by applied currents affect cerebellar activity in the mammalian cerebellum under in vivo conditions.MethodsAlternating current (AC)
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Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-17 Elena Paci, Bridget M. Lumb, Richard Apps, Charlotte L. Lawrenson, Rosalyn J. Moran
IntroductionThe extinction of fear memories is an important component in regulating defensive behaviors, contributing toward adaptive processes essential for survival. The cerebellar medial nucleus (MCN) has bidirectional connections with the ventrolateral periaqueductal gray (vlPAG) and is implicated in the regulation of multiple aspects of fear, such as conditioned fear learning and the expression
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Synaptic properties of mouse tecto-parabigeminal pathways Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-12 Kyle L. Whyland, Sean P. Masterson, Arkadiusz S. Slusarczyk, Martha E. Bickford
The superior colliculus (SC) is a critical hub for the generation of visually-evoked orienting and defensive behaviors. Among the SC’s myriad downstream targets is the parabigeminal nucleus (PBG), the mammalian homolog of the nucleus isthmi, which has been implicated in motion processing and the production of defensive behaviors. The inputs to the PBG are thought to arise exclusively from the SC but
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Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-11 Yuval Baumel, Hagar Grazya Yamin, Dana Cohen
Neuronal oscillations occur in health and disease; however, their characteristics can differ across conditions. During voluntary movement in freely moving rats, cerebellar nuclei (CN) neurons display intermittent but coherent oscillations in the theta frequency band (4–12 Hz). However, in the rat harmaline model of essential tremor, a disorder attributed to cerebellar malfunction, CN neurons display
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Variations on the theme: focus on cerebellum and emotional processing Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-10 Camilla Ciapponi, Yuhe Li, Dianela A. Osorio Becerra, Dimitri Rodarie, Claudia Casellato, Lisa Mapelli, Egidio D’Angelo
The cerebellum operates exploiting a complex modular organization and a unified computational algorithm adapted to different behavioral contexts. Recent observations suggest that the cerebellum is involved not just in motor but also in emotional and cognitive processing. It is therefore critical to identify the specific regional connectivity and microcircuit properties of the emotional cerebellum.
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Cerebellar control of fear learning via the cerebellar nuclei–Multiple pathways, multiple mechanisms? Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-09 Julie D. Urrutia Desmaison, Romain W. Sala, Ahsan Ayyaz, Pimpimon Nondhalee, Daniela Popa, Clément Léna
Fear learning is mediated by a large network of brain structures and the understanding of their roles and interactions is constantly progressing. There is a multitude of anatomical and behavioral evidence on the interconnection of the cerebellar nuclei to other structures in the fear network. Regarding the cerebellar nuclei, we focus on the coupling of the cerebellar fastigial nucleus to the fear network
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Hippocampal beta rhythms as a bridge between sensory learning and memory-guided decision-making Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-05 Jesse Thomas Miles, Kevan Scott Kidder, Sheri J. Y. Mizumori
A pillar of systems neuroscience has been the study of neural oscillations. Research into these oscillations spans brain areas, species, and disciplines, giving us common ground for discussing typically disparate fields of neuroscience. In this review, we aim to strengthen the dialog between sensory systems research and learning and memory systems research by examining a 15–40 Hz oscillation known
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Testing EEG functional connectivity between sensorimotor and face processing visual regions in individuals with congenital facial palsy Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-05 Thomas Quettier, Antonio Maffei, Filippo Gambarota, Pier Francesco Ferrari, Paola Sessa
Moebius syndrome (MBS) is characterized by the congenital absence or underdevelopment of cranial nerves VII and VI, leading to facial palsy and impaired lateral eye movements. As a result, MBS individuals cannot produce facial expressions and did not develop motor programs for facial expressions. In the latest model of sensorimotor simulation, an iterative communication between somatosensory, motor/premotor
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A disynaptic basal ganglia connection to the inferior olive: potential for basal ganglia influence on cerebellar learning Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-05 Tom J. H. Ruigrok, Xiaolu Wang, Erika Sabel-Goedknegt, Patrice Coulon, Zhenyu Gao
Recent studies have shown that the cerebellum and the basal ganglia are interconnected at subcortical levels. However, a subcortical basal ganglia connection to the inferior olive (IO), being the source of the olivocerebellar climbing fiber system, is not known. We have used classical tracing with CTb, retrograde transneuronal infection with wildtype rabies virus, conditional tracing with genetically
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Dynamic brain states in spatial neglect after stroke Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-02 Sara Spadone, Francesco de Pasquale, Anna Digiovanni, Eleonora Grande, Luigi Pavone, Stefano L. Sensi, Giorgia Committeri, Antonello Baldassarre
Previous studies indicated that spatial neglect is characterized by widespread alteration of resting-state functional connectivity and changes in the functional topology of large-scale brain systems. However, whether such network modulations exhibit temporal fluctuations related to spatial neglect is still largely unknown. This study investigated the association between brain states and spatial neglect
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The influence of action on perception spans different effectors Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-05-02 Annalisa Bosco, Pablo Sanz Diez, Matteo Filippini, Patrizia Fattori
Perception and action are fundamental processes that characterize our life and our possibility to modify the world around us. Several pieces of evidence have shown an intimate and reciprocal interaction between perception and action, leading us to believe that these processes rely on a common set of representations. The present review focuses on one particular aspect of this interaction: the influence
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The cerebellum and fear extinction: evidence from rodent and human studies Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-04-21 Alice Doubliez, Enzo Nio, Fernando Senovilla-Sanz, Vasiliki Spatharioti, Richard Apps, Dagmar Timmann, Charlotte L. Lawrenson
The role of the cerebellum in emotional control has gained increasing interest, with studies showing it is involved in fear learning and memory in both humans and rodents. This review will focus on the contributions of the cerebellum to the extinction of learned fear responses. Extinction of fearful memories is critical for adaptive behaviour, and is clinically relevant to anxiety disorders such as
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Editorial: Deciphering population neuronal dynamics: from theories to experiments. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-04-20 Hongdian Yang,Woodrow L Shew,Shan Yu,Artur Luczak,Carsen Stringer,Michael Okun
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Role of cerebellum in sleep-dependent memory processes Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-04-18 Andrew Jackson, Wei Xu
The activities and role of the cerebellum in sleep have, until recently, been largely ignored by both the sleep and cerebellum fields. Human sleep studies often neglect the cerebellum because it is at a position in the skull that is inaccessible to EEG electrodes. Animal neurophysiology sleep studies have focussed mainly on the neocortex, thalamus and the hippocampus. However, recent neurophysiological
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Prefrontal modulation of anxiety through a lens of noradrenergic signaling Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-04-17 Nadia N. Bouras, Nancy R. Mack, Wen-Jun Gao
Anxiety disorders are the most common class of mental illness in the U.S., affecting 40 million individuals annually. Anxiety is an adaptive response to a stressful or unpredictable life event. Though evolutionarily thought to aid in survival, excess intensity or duration of anxiogenic response can lead to a plethora of adverse symptoms and cognitive dysfunction. A wealth of data has implicated the
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Arousal system stimulation and anesthetic state alter visuoparietal connectivity Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-04-17 Axel Hutt, Anthony G. Hudetz
Cortical information processing is under the precise control of the ascending arousal system (AAS). Anesthesia suppresses cortical arousal that can be mitigated by exogenous stimulation of the AAS. The question remains to what extent cortical information processing is regained by AAS stimulation. We investigate the effect of electrical stimulation of the nucleus Pontis Oralis (PnO), a distinct source
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Engaging distributed cortical and cerebellar networks through motor execution, observation, and imagery Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-04-11 Julia U. Henschke, Janelle M. P. Pakan
When we interact with the environment around us, we are sometimes active participants, making directed physical motor movements and other times only mentally engaging with our environment, taking in sensory information and internally planning our next move without directed physical movement. Traditionally, cortical motor regions and key subcortical structures such as the cerebellum have been tightly
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Editorial: Role of brain oscillations in neurocognitive control systems. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-31 Golnaz Baghdadi,Chella Kamarajan,Fatemeh Hadaeghi
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Cerebellar contribution to the regulation of defensive states Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-31 Gabriela Neubert da Silva, Nina Seiffert, Philip Tovote
Despite fine tuning voluntary movement as the most prominently studied function of the cerebellum, early human studies suggested cerebellar involvement emotion regulation. Since, the cerebellum has been associated with various mood and anxiety-related conditions. Research in animals provided evidence for cerebellar contributions to fear memory formation and extinction. Fear and anxiety can broadly
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Cerebellar control of thalamocortical circuits for cognitive function: A review of pathways and a proposed mechanism Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-30 Detlef H. Heck, Mia B. Fox, Brittany Correia Chapman, Samuel S. McAfee, Yu Liu
There is general agreement that cerebrocerebellar interactions via cerebellothalamocortical pathways are essential for a cerebellar cognitive and motor functions. Cerebellothalamic projections were long believed target mainly the ventral lateral (VL) and part of the ventral anterior (VA) nuclei, which project to cortical motor and premotor areas. Here we review new insights from detailed tracing studies
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Editorial: Unravelling the complex and multifaceted role of the cerebellum in health and disease. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-23 Paul James Mathews,Anne-Lise Paradis,Marija Cvetanovic,Erik Sean Carlson,Krystal Lynn Parker
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Editorial: Functional columnar organization and long-range circuits in different cortical systems. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-20 Kerstin E Schmidt,Ralf A W Galuske
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Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-20 Estelle A. C. Bonin, Nicolas Lejeune, Emilie Szymkowicz, Vincent Bonhomme, Charlotte Martial, Olivia Gosseries, Steven Laureys, Aurore Thibaut
The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS). In a clinical setting, the detection of signs of pain and nociception by the medical staff is therefore essential for the wellbeing and management of these patients. However, there is still a lot
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7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-15 Florence Rawlings-Mortimer, Alberto Lazari, Cristiana Tisca, Mohamed Tachrount, Aurea B. Martins-Bach, Karla L. Miller, Jason P. Lerch, Heidi Johansen-Berg
Introduction: 7,8-dihydroxyflavone (7,8-DHF) is a low molecular weight compound that can cross the blood brain barrier and has been implicated in numerous functions and behaviours. It is thought to have neuroprotective capability and has been shown to alleviate symptoms in a wide range of diseases.Methods: 7,8-DHF was administered systemically to wildtype mice during Morris water maze training. Long-term
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Editorial: Reconfiguration of neuronal ensembles throughout learning. Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-14 Luis Carrillo-Reid,Masakazu Agetsuma,Emilio Kropff
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Machine learning approaches and non-linear processing of extracted components in frontal region to predict rTMS treatment response in major depressive disorder Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-10 Elias Ebrahimzadeh, Farahnaz Fayaz, Lila Rajabion, Masoud Seraji, Fatemeh Aflaki, Ahmad Hammoud, Zahra Taghizadeh, Mostafa Asgarinejad, Hamid Soltanian-Zadeh
Predicting the therapeutic result of repetitive transcranial magnetic stimulation (rTMS) treatment could save time and costs as ineffective treatment can be avoided. To this end, we presented a machine-learning-based strategy for classifying patients with major depression disorder (MDD) into responders (R) and nonresponders (NR) to rTMS treatment. Resting state EEG data were recorded using 32 electrodes
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The little brain and the seahorse: Cerebellar-hippocampal interactions Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-06 Jessica M. Froula, Shayne D. Hastings, Esther Krook-Magnuson
There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate coordinated coactivation and a bidirectional functional connectivity relevant for various physiological
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Sex differences in glutamate AMPA receptor subunits mRNA with fast gating kinetics in the mouse cochlea Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-03-02 Nicholas R. Lozier, Steven Muscio, Indra Pal, Hou-Ming Cai, María E. Rubio
Evidence shows that females have increased supra-threshold peripheral auditory processing compared to males. This is indicated by larger auditory brainstem responses (ABR) wave I amplitude, which measures afferent spiral ganglion neuron (SGN)-auditory nerve synchrony. However, the underlying molecular mechanisms of this sex difference are mostly unknown. We sought to elucidate sex differences in ABR
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Cortical processing during robot and functional electrical stimulation Front. Syst. Neurosci. (IF 3.0) Pub Date : 2023-02-28 Woosang Cho, Carmen Vidaurre, Jinung An, Niels Birbaumer, Ander Ramos-Murguialday
Introduction Like alpha rhythm, the somatosensory mu rhythm is suppressed in the presence of somatosensory inputs by implying cortical excitation. Sensorimotor rhythm (SMR) can be classified into two oscillatory frequency components: mu rhythm (8–13 Hz) and beta rhythm (14–25 Hz). The suppressed/enhanced SMR is a neural correlate of cortical activation related to efferent and afferent movement information