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The proteomic landscape of microglia in health and disease Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-15 Emma Davis, Amy F. Lloyd
Microglia are the resident immune cells of the central nervous system (CNS) and as such play crucial roles in regulating brain homeostasis. Their presence in neurodegenerative diseases is known, with neurodegeneration-associated risk genes heavily expressed in microglia, highlighting their importance in contributing to disease pathogenesis. Transcriptomics studies have uncovered the heterogeneous landscape
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Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-15 Yara Izhiman, Leyla Esfandiari
Peripheral nerve injuries lead to significant morbidity and adversely affect quality of life. The peripheral nervous system harbors the unique trait of autonomous regeneration; however, achieving successful regeneration remains uncertain. Research continues to augment and expedite successful peripheral nerve recovery, offering promising strategies for promoting peripheral nerve regeneration (PNR).
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Genetic tools for studying cochlear inhibition Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-15 Eleftheria Slika, Paul Albert Fuchs
Efferent feedback to the mammalian cochlea includes cholinergic medial olivocochlear neurons (MOCs) that release ACh to hyperpolarize and shunt the voltage change that drives electromotility of outer hair cells (OHCs). Via brainstem connectivity, MOCs are activated by sound in a frequency- and intensity-dependent manner, thereby reducing the amplification of cochlear vibration provided by OHC electromotility
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Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-14 Atefeh Asadi, Mojtaba Madadi Asl, Alireza Valizadeh, Matjaž Perc
IntroductionNeural interactions in the brain are affected by transmission delays which may critically alter signal propagation across different brain regions in both normal and pathological conditions. The effect of interaction delays on the dynamics of the generic neural networks has been extensively studied by theoretical and computational models. However, the role of transmission delays in the development
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Updates of the role of B-cells in ischemic stroke Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-14 Silin Wu, Sidra Tabassum, Cole T. Payne, Heng Hu, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren
Ischemic stroke is a major disease causing death and disability in the elderly and is one of the major diseases that seriously threaten human health and cause a great economic burden. In the early stage of ischemic stroke, neuronal structure is destroyed, resulting in death or damage, and the release of a variety of damage-associated pattern molecules induces an increase in neuroglial activation, peripheral
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Microglia at the blood brain barrier in health and disease Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Meredith G. Mayer, Tracy Fischer
The blood brain barrier (BBB) plays a crucial role in maintaining brain homeostasis by selectively preventing the entry of substances from the peripheral blood into the central nervous system (CNS). Comprised of endothelial cells, pericytes, and astrocytes, this highly regulated barrier encompasses the majority of the brain’s vasculature. In addition to its protective function, the BBB also engages
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Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-11 Morgan A. Taylor, Olga N. Kokiko-Cochran
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and psychiatric consequences that can persist long after injury. TBI induces a physiological stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of injury on the stress response become more complex in the long term. Clinical and experimental evidence suggests long lasting
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Glitches in the brain: the dangerous relationship between radiotherapy and brain fog Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-07 Noemi Marino, Martina Bedeschi, Melania Elettra Vaccari, Marco Cambiaghi, Anna Tesei
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed of information processing, multi-tasking, and mental health functioning, a series of symptoms known as “brain fog.” The severity and duration of such effects can vary depending on age, cancer type, and treatment regimens. In particular, every year, hundreds of thousands of patients worldwide undergo radiotherapy
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Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-07 Lijuan Wang, Xiansong Fang, Baodian Ling, Fangsheng Wang, Yu Xia, Wenjuan Zhang, Tianyu Zhong, Xiaoling Wang
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Although a great deal of energy and financial resources have been invested in disease-related research, breakthroughs in therapeutic approaches remain elusive. The breakdown of cells usually happens
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Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Yiyu Sun, Di Chen, Tao Dai, Ziyou Yu, Hui Xie, Xiangsheng Wang, Wenjie Zhang
Injuries to axons within the central nervous system (CNS) pose a substantial clinical challenge due to their limited regenerative capacity. This study investigates the therapeutic potential of Cell-free fat extract (CEFFE) in CNS injury. CEFFE was injected intravitreally after the optic nerve was crushed. Two weeks post-injury, quantification of regenerated axons and survival rates of retinal ganglion
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Microglia-neuron interactions in schizophrenia Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Sophia-Marie Hartmann, Johanna Heider, Richard Wüst, Andreas J. Fallgatter, Hansjürgen Volkmer
Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelopmental disorders such as schizophrenia. Microglia, which are the primary innate immune cells of the brain, are crucial for the refinement of the synaptic circuitry during early brain development by synaptic pruning and the regulation of synaptic plasticity during adulthood. Schizophrenia
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5-HT1F receptor agonism induces mitochondrial biogenesis and increases cellular function in brain microvascular endothelial cells Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-05 Natalie E. Scholpa, Epiphani C. Simmons, Austin D. Thompson, Seth S. Carroll, Rick G. Schnellmann
IntroductionVascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HT1FR) agonism induces mitochondrial biogenesis (MB) in multiple organ systems, including the CNS.MethodsLasmiditan is a selective 5-HT1FR agonist
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Out of the core: the impact of focal ischemia in regions beyond the penumbra Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-03-05 Ludmila Koukalova, Martina Chmelova, Zuzana Amlerova, Lydia Vargova
The changes in the necrotic core and the penumbra following induction of focal ischemia have been the focus of attention for some time. However, evidence shows, that ischemic injury is not confined to the primarily affected structures and may influence the remote areas as well. Yet many studies fail to probe into the structures beyond the penumbra, and possibly do not even find any significant results
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Visualizing the trans-synaptic arrangement of synaptic proteins by expansion microscopy Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-29 Stefan Sachs, Sebastian Reinhard, Janna Eilts, Markus Sauer, Christian Werner
High fidelity synaptic neurotransmission in the millisecond range is provided by a defined structural arrangement of synaptic proteins. At the presynapse multi-epitope scaffolding proteins are organized spatially at release sites to guarantee optimal binding of neurotransmitters at receptor clusters. The organization of pre- and postsynaptic proteins in trans-synaptic nanocolumns would thus intuitively
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MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-29 Océane Perdaens, Pauline Bottemanne, Vincent van Pesch
IntroductionDemyelination is one of the hallmarks of multiple sclerosis (MS). While remyelination occurs during the disease, it is incomplete from the start and strongly decreases with its progression, mainly due to the harm to oligodendrocyte progenitor cells (OPCs), causing irreversible neurological deficits and contributing to neurodegeneration. Therapeutic strategies promoting remyelination are
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Apoptosis and turnover disruption of olfactory sensory neurons in eosinophilic chronic rhinosinusitis Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-28 Yuetong Chen, Minghan Li, Juan Lu
Olfactory dysfunction (OD) is one of the important and difficult-to-treat symptoms of eosinophilic chronic rhinosinusitis (CRS), which is typically associated with type 2 inflammation where eosinophils (EOSs) function as both effectors and initiators. Eosinophilic infiltration in the olfactory mucosa (OM) is associated with severe OD, mucosal erosion, and more loss of olfactory sensory neurons (OSNs)
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Reactive gliosis in traumatic brain injury: a comprehensive review Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-28 Zuzana Amlerova, Martina Chmelova, Miroslava Anderova, Lydia Vargova
Traumatic brain injury (TBI) is one of the most common pathological conditions impacting the central nervous system (CNS). A neurological deficit associated with TBI results from a complex of pathogenetic mechanisms including glutamate excitotoxicity, inflammation, demyelination, programmed cell death, or the development of edema. The critical components contributing to CNS response, damage control
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Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-26 Kyle A. Lyman, Ye Han, Andrew P. Robinson, Samuel E. Weinberg, Daniel W. Fisher, Robert J. Heuermann, Reagan E. Lyman, Dong Kyu Kim, Andreas Ludwig, Navdeep S. Chandel, Mark D. Does, Stephen D. Miller, Dane M. Chetkovich
Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (Ih) were recently identified in mature OLG and shown to
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Proteasome localization and activity in pig brain and in vivo small molecule screening for activators Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-26 Adriana Amrein Almira, May W. Chen, Nagat El Demerdash, Cameron Javdan, Dongseok Park, Jennifer K. Lee, Lee J. Martin
IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human lifespan in several forms of brain injury and disease. Drugs that activate brain proteasomes in vivo could thus have a broad therapeutic impact in neurology.MethodsUsing pigs, a clinically relevant large animal with a functionally compartmental gyrencephalic cerebral cortex, we evaluated
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Transcranial Direct Current Stimulation in neurogenetic syndromes: new treatment perspectives for Down syndrome? Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-22 Alessio Faralli, Elisa Fucà, Giulia Lazzaro, Deny Menghini, Stefano Vicari, Floriana Costanzo
This perspective review aims to explore the potential neurobiological mechanisms involved in the application of transcranial Direct Current Stimulation (tDCS) for Down syndrome (DS), the leading cause of genetically-based intellectual disability. The neural mechanisms underlying tDCS interventions in genetic disorders, typically characterized by cognitive deficits, are grounded in the concept of brain
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Innate lymphoid cells in neuroinflammation Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-21 Daria Kveštak, Andrea Mihalić, Stipan Jonjić, Ilija Brizić
Innate lymphoid cells (ILCs) are largely tissue-resident cells that participate in the maintenance of tissue homeostasis and react early to inflammatory events. Mature ILCs are divided into three major groups based on the transcription factors required for their development and function. Under physiological conditions, ILCs are present within the choroid plexus and meninges while the CNS parenchyma
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A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-21 Luis-Manuel Rodríguez-Pérez, Javier López-de-San-Sebastián, Isabel de Diego, Aníbal Smith, Ruth Roales-Buján, Antonio J. Jiménez, Patricia Paez-Gonzalez
IntroductionDysgenesis of the corpus callosum is present in neurodevelopmental disorders and coexists with hydrocephalus in several human congenital syndromes. The mechanisms that underlie the etiology of congenital hydrocephalus and agenesis of the corpus callosum when they coappear during neurodevelopment persist unclear. In this work, the mechanistic relationship between both disorders is investigated
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Comparison of the effects of EGF, FGF-b, and NGF on the proliferation, migration, and reprogramming of primary rat Müller cells Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-21 Yanying Liao, Miaoqin Wu
PurposeDuring the healing process of full-thickness macular holes (FTMHs), the closure and recovery of the hole depend on the migration, proliferation, and activation of Müller cells to promote the closure of holes and restoration of the photosensitive layer. In this study, we investigated the ability of the epidermal growth factor (EGF), fibroblast growth factor-basic (FGF-b), and nerve growth factor
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Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-21 Rebecca Boland, Olga N. Kokiko-Cochran
Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained neuroinflammation after TBI is often associated with poor outcome. As a result, increased attention has been placed on the role of immune cells in post-injury recovery. Microglia are highly dynamic after TBI and play a key role in the post-injury neuroinflammatory response. Therefore, microglia represent
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TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-21 Evelien Van Schoor, Dufie Strubbe, Elke Braems, Jochen Weishaupt, Albert C. Ludolph, Philip Van Damme, Dietmar Rudolf Thal, Valérie Bercier, Ludo Van Den Bosch
Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a downregulation of TUBA4A protein expression was observed in familial as well as sporadic ALS brain tissue. To investigate whether a decreased TUBA4A expression could be a driving factor in ALS pathogenesis, we assessed whether TUBA4A knockdown in zebrafish could recapitulate an ALS-like
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Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington’s disease Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-20 Emanuela Paldino, Giorgia Migliorato, Francesca R. Fusco
Mechanisms of tissue damage in Huntington’s disease (HD) involve excitotoxicity, mitochondrial damage, and neuroinflammation, including microglia activation. CD47 is a membrane protein that interacts with the inhibitory immunoreceptor SIRPα. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, promoting a “don’t-eat-me” signal. These proteins are involved
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nArgBP2 together with GKAP and SHANK3 forms a dynamic layered structure Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-19 Sang-Eun Lee, Sunghoe Chang
nArgBP2, a protein whose disruption is implicated in intellectual disability, concentrates in excitatory spine-synapses. By forming a triad with GKAP and SHANK, it regulates spine structural rearrangement. We here find that GKAP and SHANK3 concentrate close to the synaptic contact, whereas nArgBP2 concentrates more centrally in the spine. The three proteins collaboratively form biomolecular condensates
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A helping hand: roles for accessory cells in the sense of touch across species Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-16 David R. Logan, Jesse Hall, Laura Bianchi
During touch, mechanical forces are converted into electrochemical signals by tactile organs made of neurons, accessory cells, and their shared extracellular spaces. Accessory cells, including Merkel cells, keratinocytes, lamellar cells, and glia, play an important role in the sensation of touch. In some cases, these cells are intrinsically mechanosensitive; however, other roles include the release
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Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-16 Masashi Watanave, Mika Kawachi, Ayumu Konno, Ryo Aoki, Yuuki Fukai, Yasunori Matsuzaki, Ryosuke Kaneko, Hirokazu Hirai
Protein kinase C γ (PKCγ), a neuronal isoform present exclusively in the central nervous system, is most abundantly expressed in cerebellar Purkinje cells (PCs). Targeted deletion of PKCγ causes a climbing fiber synapse elimination in developing PCs and motor deficit. However, physiological roles of PKCγ in adult mouse PCs are little understood. In this study, we aimed to unravel the roles of PKCγ
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Fluorescence microscopy shadow imaging for neuroscience Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-15 V. V. G. Krishna Inavalli, Virginia Puente Muñoz, Jonathan E. Draffin, Jan Tønnesen
Fluorescence microscopy remains one of the single most widely applied experimental approaches in neuroscience and beyond and is continuously evolving to make it easier and more versatile. The success of the approach is based on synergistic developments in imaging technologies and fluorophore labeling strategies that have allowed it to greatly diversify and be used across preparations for addressing
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Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-15 Zihan Li, Jiarui Wu, Tianyuan Zhao, Yiyun Wei, Yajing Xu, Zongjian Liu, Xiaoqiong Li, Xuechai Chen
Due to the increased crewed spaceflights in recent years, it is vital to understand how the space environment affects human health. A lack of gravitational force is known to risk multiple physiological functions of astronauts, particularly damage to the central nervous system (CNS). As innate immune cells of the CNS, microglia can transition from a quiescent state to a pathological state, releasing
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Established and emerging techniques for the study of microglia: visualization, depletion, and fate mapping Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-15 Bianca Caroline Bobotis, Torin Halvorson, Micaël Carrier, Marie-Ève Tremblay
The central nervous system (CNS) is an essential hub for neuronal communication. As a major component of the CNS, glial cells are vital in the maintenance and regulation of neuronal network dynamics. Research on microglia, the resident innate immune cells of the CNS, has advanced considerably in recent years, and our understanding of their diverse functions continues to grow. Microglia play critical
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Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Iva Cantando, Cristiana Centofanti, Giuseppina D’Alessandro, Cristina Limatola, Paola Bezzi
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by elusive underlying mechanisms. Recent attention has focused on the involvement of astrocytes and microglia in ASD pathology. These glial cells play pivotal roles in maintaining neuronal homeostasis, including the regulation of metabolism. Emerging evidence suggests a potential association between ASD and inborn
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Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Christopher T. Rhodes, Dhanya Asokumar, Mira Sohn, Shovan Naskar, Lielle Elisha, Parker Stevenson, Dongjin R. Lee, Yajun Zhang, Pedro P. Rocha, Ryan K. Dale, Soohyun Lee, Timothy J. Petros
IntroductionEnhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we explore the role of Ezh2 in forebrain GABAergic interneuron development.MethodsWe removed Ezh2 in the MGE by generating Nkx2-1Cre;Ezh2 conditional knockout mice. We then characterized changes in MGE-derived interneuron fate and
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The role of glial cells in mental illness: a systematic review on astroglia and microglia as potential players in schizophrenia and its cognitive and emotional aspects Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Daniela Laricchiuta, Martina Papi, Davide Decandia, Anna Panuccio, Debora Cutuli, Maurizio Peciccia, Claudia Mazzeschi, Laura Petrosini
Schizophrenia is a complex and severe mental disorder that affects approximately 1% of the global population. It is characterized by a wide range of symptoms, including delusions, hallucinations, disorganized speech and behavior, and cognitive impairment. Recent research has suggested that the immune system dysregulation may play a significant role in the pathogenesis of schizophrenia, and glial cells
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Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Rasiel Beltran-Casanueva, Aracelis Hernández-García, Paula de Amo García, Encarnación Blanco-Reina, Pedro Serrano-Castro, Natalia García-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narváez
IntroductionThis study may unveil novel insights into the interactions between neuropeptide Y receptor 1 (NPY1R) and galanin receptor 2 (GALR2), in the dentate gyrus of the dorsal hippocampus, shedding light on their role in neurogenesis and cognitive functions. Existing literature highlights the potential of these interactions in enhancing learning and memory, yet detailed mechanisms remain underexplored
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Kinetics and functional consequences of BK channels activation by N-type Ca2+ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Laila Ananda Blömer, Elisabetta Giacalone, Fatima Abbas, Luiza Filipis, Domenico Tegolo, Michele Migliore, Marco Canepari
The back-propagation of an action potential (AP) from the axon/soma to the dendrites plays a central role in dendritic integration. This process involves an intricate orchestration of various ion channels, but a comprehensive understanding of the contribution of each channel type remains elusive. In this study, we leverage ultrafast membrane potential recordings (Vm) and Ca2+ imaging techniques to
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Optimal decoding of neural dynamics occurs at mesoscale spatial and temporal resolutions Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Toktam Samiei, Zhuowen Zou, Mohsen Imani, Erfan Nozari
IntroductionUnderstanding the neural code has been one of the central aims of neuroscience research for decades. Spikes are commonly referred to as the units of information transfer, but multi-unit activity (MUA) recordings are routinely analyzed in aggregate forms such as binned spike counts, peri-stimulus time histograms, firing rates, or population codes. Various forms of averaging also occur in
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Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-14 Kristin Glotzbach, Andreas Faissner
IntroductionThe lack of regenerative capacity of the central nervous system is one of the major challenges nowadays. The knowledge of guidance cues that trigger differentiation, proliferation, and migration of neural stem and progenitor cells is one key element in regenerative medicine. The extracellular matrix protein tenascin-C (Tnc) is a promising candidate to regulate cell fate due to its expression
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Unique pathways downstream of TLR-4 and TLR-7 activation: sex-dependent behavioural, cytokine, and metabolic consequences Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-13 Isobel K. Dunstan, Ross McLeod, Daniel E. Radford-Smith, Wenzheng Xiong, Trinity Pate, Fay Probert, Daniel C. Anthony
IntroductionPost-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic interplay between behaviour, metabolism, and inflammation downstream of TLR-7 activation compared to TLR-4 activation in
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Apoptosis signal-regulating kinase 1 (Ask1) deficiency alleviates MPP+-induced impairment of evoked dopamine release in the mouse hippocampus Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-13 Fang Zhao, Chuhan Li, Yinghan Zhuang, Yan Yan, Yanqin Gao, Thomas Behnisch
The dopaminergic system is susceptible to dysfunction in numerous neurological diseases, including Parkinson’s disease (PD). In addition to motor symptoms, some PD patients may experience non-motor symptoms, including cognitive and memory deficits. A possible explanation for their manifestation is a disturbed pattern of dopamine release in brain regions involved in learning and memory, such as the
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Transcriptional precision in photoreceptor development and diseases – Lessons from 25 years of CRX research Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-13 Yiqiao Zheng, Shiming Chen
The vertebrate retina is made up of six specialized neuronal cell types and one glia that are generated from a common retinal progenitor. The development of these distinct cell types is programmed by transcription factors that regulate the expression of specific genes essential for cell fate specification and differentiation. Because of the complex nature of transcriptional regulation, understanding
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Role of a Pdlim5:PalmD complex in directing dendrite morphology Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-13 Yogesh Srivastava, Maxsam Donta, Lydia L. Mireles, Adriana Paulucci-Holthauzen, M. Neal Waxham, Pierre D. McCrea
Neuronal connectivity is regulated during normal brain development with the arrangement of spines and synapses being dependent on the morphology of dendrites. Further, in multiple neurodevelopmental and aging disorders, disruptions of dendrite formation or shaping is associated with atypical neuronal connectivity. We showed previously that Pdlim5 binds delta-catenin and promotes dendrite branching
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Absence of meningeal mast cells in the Mitf mutant mouse Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-09 Alba Sabaté San José, Petur Henry Petersen
Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf
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Peripheral memory B cells in multiple sclerosis vs. double negative B cells in neuromyelitis optica spectrum disorder: disease driving B cell subsets during CNS inflammation Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-07 M. P. Tieck, N. Vasilenko, C. Ruschil, M. C. Kowarik
B cells are fundamental players in the pathophysiology of autoimmune diseases of the central nervous system, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). A deeper understanding of disease-specific B cell functions has led to the differentiation of both diseases and the development of different treatment strategies. While NMOSD is strongly associated with pathogenic
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Reduced menthol sensitivity in a prodromal Parkinson’s disease model induced by intranasal rotenone treatment Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-06 Hajime Sato, Keitaro Satoh, Kazunori Nozaki, Misato Yugawa, Takafumi Kato, Hiroki Toyoda, Ayano Katagiri, Naoto Suda, Kazunori Adachi
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms, and it is associated with several prodromal non-motor symptoms, including an impaired sense of smell, taste and touch. We previously reported that bitter taste impairments occur independently of olfactory impairments in an early-stage PD animal model using short-term intranasal rotenone-treated mice. Cool temperatures
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Molecular mechanisms underlying inherited photoreceptor degeneration as targets for therapeutic intervention Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-02 Andrea Bighinati, Elisa Adani, Agnese Stanzani, Sara D’Alessandro, Valeria Marigo
Retinitis pigmentosa (RP) is a form of retinal degeneration characterized by primary degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision impairment and finally blindness. This is a rare disease with mutations in several genes and high genetic heterogeneity. A challenging effort has been the characterization of the molecular mechanisms underlying photoreceptor cell
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A combinatory genetic strategy for targeting neurogliaform neurons in the mouse basolateral amygdala Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-02-01 Attila Ozsvár, Meike Claudia Sieburg, Monica Dahlstrup Sietam, Wen-Hsien Hou, Marco Capogna
The mouse basolateral amygdala (BLA) contains various GABAergic interneuron subpopulations, which have distinctive roles in the neuronal microcircuit controlling numerous behavioral functions. In mice, roughly 15% of the BLA GABAergic interneurons express neuropeptide Y (NPY), a reasonably characteristic marker for neurogliaform cells (NGFCs) in cortical-like brain structures. However, genetically
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Transcriptional consequences of trisomy 21 on neural induction Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-30 José L. Martinez, Jennifer G. Piciw, Madeline Crockett, Isabella A. Sorci, Nikunj Makwana, Carissa L. Sirois, Yathindar Giffin-Rao, Anita Bhattacharyya
IntroductionDown syndrome, caused by trisomy 21, is a complex developmental disorder associated with intellectual disability and reduced growth of multiple organs. Structural pathologies are present at birth, reflecting embryonic origins. A fundamental unanswered question is how an extra copy of human chromosome 21 contributes to organ-specific pathologies that characterize individuals with Down syndrome
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Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-29 Fazeleh Etebar, Damien G. Harkin, Anthony R. White, Samantha J. Dando
Microglia play crucial roles in immune responses and contribute to fundamental biological processes within the central nervous system (CNS). In neurodegenerative diseases, microglia undergo functional changes and can have both protective and pathogenic roles. Microglia in the retina, as an extension of the CNS, have also been shown to be affected in many neurological diseases. While our understanding
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Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-25 Jose A. Fernández-Albarral, Ana I. Ramírez, Rosa de Hoz, José A. Matamoros, Elena Salobrar-García, Lorena Elvira-Hurtado, Inés López-Cuenca, Lidia Sánchez-Puebla, Juan J. Salazar, José M. Ramírez
Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of their axons, as well as damage and remodeling of the lamina cribrosa are the main events in the pathogenesis of glaucoma. Different molecular pathways are involved in RGC death, which are triggered and exacerbated as a
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The Mongolian gerbil as an advanced model to study cone system physiology Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-25 Alexander Günter, Soumaya Belhadj, Mathias W. Seeliger, Regine Mühlfriedel
In this work, we introduce a diurnal rodent, the Mongolian gerbil (Meriones unguiculatus) (MG) as an alternative to study retinal cone system physiology and pathophysiology in mice. The cone system is of particular importance, as it provides high-acuity and color vision and its impairment in retinal disorders is thus especially disabling. Despite their nocturnal lifestyle, mice are currently the most
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Human iPSC-derived retinal organoids develop robust Alzheimer’s disease neuropathology Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-23 Ethan James, Anne Vielle, Karen Cusato, Helen Li, Byoungin Lee, Shama Parween, Anna Howell, Noah R. Johnson, Heidi J. Chial, Huntington Potter, M. Natalia Vergara
Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, affects nearly 50 million people worldwide. Amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) of phosphorylated Tau protein (pTau) are key histopathological features of the disease in the brain, and recent advances have also identified AD histopathology in the retina. Thus, the retina represents a
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Cost-effective strategies to knock down genes of interest in the retinas of adult zebrafish Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-23 Eyad Shihabeddin, Abirami Santhanam, Alexandra L. Aronowitz, John O’Brien
High throughput sequencing has generated an enormous amount of information about the genes expressed in various cell types and tissues throughout the body, and about how gene expression changes over time and in diseased conditions. This knowledge has made targeted gene knockdowns an important tool in screening and identifying the roles of genes that are differentially expressed among specific cells
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Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-19 Michelle E. Watts, Richard M. Giadone, Alban Ordureau, Kristina M. Holton, J. Wade Harper, Lee L. Rubin
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely limited treatment options. Identification of effective treatments has been limited in part by the lack of predictive animal models for complex human disorders. Here, we utilized pharmacologic ER stressors to exacerbate underlying sensitivities conferred by ALS patient genetics in induced pluripotent stem cell
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MicroRNA profile of extracellular vesicles released by Müller glial cells Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-18 William D. B. Lamb, Karen Eastlake, Joshua Luis, Najam A. Sharif, Peng T. Khaw, G. Astrid Limb
IntroductionAs with any other radial glia in the central nervous system, Müller glia derive from the same neuroepithelial precursors, perform similar functions, and exhibit neurogenic properties as radial glia in the brain. Müller glial cells retain progenitor-like characteristics in the adult human eye and can partially restore visual function upon intravitreal transplantation into animal models of
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Claudin-11 in health and disease: implications for myelin disorders, hearing, and fertility Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-17 Sophia C. Gjervan, Oguz K. Ozgoren, Alexander Gow, Sylvia Stockler-Ipsiroglu, Mahmoud A. Pouladi
Claudin-11 plays a critical role in multiple physiological processes, including myelination, auditory function, and spermatogenesis. Recently, stop-loss mutations in CLDN11 have been identified as a novel cause of hypomyelinating leukodystrophy (HLD22). Understanding the multifaceted roles of claudin-11 and the potential pathogenic mechanisms in HLD22 is crucial for devising targeted therapeutic strategies
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Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3–/y mouse model of ASDs Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-17 Rocco Pizzarelli, Domenico Pimpinella, Christian Jacobs, Alice Tartacca, Uarda Kullolli, Hannah Monyer, Cristina M. Alberini, Marilena Griguoli
Autism spectrum disorders (ASDs) comprise developmental disabilities characterized by impairments of social interaction and repetitive behavior, often associated with cognitive deficits. There is no current treatment that can ameliorate most of the ASDs symptomatology; thus, identifying novel therapies is urgently needed. Here, we used the Neuroligin 3 knockout mouse (NLG3–/y), a model that recapitulates
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The role of apoptosis in spinal cord injury: a bibliometric analysis from 1994 to 2023 Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-16 Siqiao Wang, Liming Cheng
BackgroundApoptosis after spinal cord injury (SCI) plays a pivotal role in the secondary injury mechanisms, which cause the ultimate neurologic insults. A better understanding of the molecular and cellular basis of apoptosis in SCI allows for improved glial and neuronal survival via the administrations of anti-apoptotic biomarkers. The knowledge structure, development trends, and research hotspots
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Non-neoplastic astrocytes: key players for brain tumor progression Front. Cell. Neurosci. (IF 5.3) Pub Date : 2024-01-16 Myriam Catalano, Cristina Limatola, Flavia Trettel
Astrocytes are highly plastic cells whose activity is essential to maintain the cerebral homeostasis, regulating synaptogenesis and synaptic transmission, vascular and metabolic functions, ions, neuro- and gliotransmitters concentrations. In pathological conditions, astrocytes may undergo transient or long-lasting molecular and functional changes that contribute to disease resolution or exacerbation