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Amyloid Precursor Protein Variant, E665D, Associated With Unique Clinical and Biomarker Phenotype Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2021-01-14 Justin R. Abbatemarco; Stephen E. Jones; Mykol Larvie; Lynn M. Bekris; Maria E. Khrestian; Kamini Krishnan; James B. Leverenz
We describe a clinical, imaging and biomarker phenotype associated with an amyloid precursor gene (APP) E665D variant in a 45-year-old man with progressive cognitive and behavioral dysfunction. Brain MRI showed bilateral, confluent T2 hyperintensities predominantly in the anterior white matter. Amyloid imaging and CSF testing were consistent with amyloid deposition. 7 Tesla MRI revealed cerebral microhemorrhages
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Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-12-14 Joseph S. D’Arrigo
By incorporating appropriate drug(s) into lipid (biobased) nanocarriers, one obtains a combination therapeutic for dementia treatment that targets certain cell-surface scavenger receptors (mainly class B type I, or “SR-BI”) and thereby crosses the blood-brain barrier. The cardiovascular risk factors for dementia trigger widespread inflammation -- which lead to neurodegeneration, gradual cognitive/memory
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The Effects of COVID-19 Home Confinement in Dementia Care: Physical and Cognitive Decline, Severe Neuropsychiatric Symptoms and Increased Caregiving Burden Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-12-09 Flávia Borges-Machado; Duarte Barros; Óscar Ribeiro; Joana Carvalho
Purpose: This study aims to analyze home confinement impact on individuals with neurocognitive disorders (NCD) through informal caregiver’s perspective and examine how it has affected caregiving burden. Methods: Thirty-six caregivers (64.94 ± 13.54 years, 41.7% female) of individuals with NCD (74.28 ± 6.76 years, 66.7% female) selected from the Body & Brain exercise program were interviewed over the
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A Study on PHF-Tau Network Effected by Apolipoprotein E4 Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-12-01 Yuan Li; Zhijun Yao; Yongqing Yang; Feng Zhao; Yu Fu; Ying Zou; Bin Hu; Alzheimer’s Disease Neuroimaging Initiative
Apolipoprotein E 4 Allele (APOE 4) is an important factors in Mild cognitive impairment (MCI) and Alzheimer’s disease(AD). It plays a primary role in abnormal modification of aggregated Tau protein-paired helical filaments Tau (PHF-Tau). In this study, 143 subjects with PHF-Tau PET were divided into 2 groups (APOE 4 carriers and noncarriers). The measurements of the PHF-Tau network properties and resilient
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Classification of Dementia Severity in Taiwan Based on History-Based Clinical Diagnosis System Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-11-11 Yun Fah Chang; Woan Yee Loi; Pai-Yi Chiu; Huang-Nan Huang
Background/Aims: This study used HAICDDS screening questionnaire to classify the severity of dementia in Taiwan based on the clinical dementia rating scale. Methods: LDA was applied to 6,328 Taiwanese clinical patients for classification purposes. Clustering method was used to identify the associated influential symptoms for each severity level. Result: LDA shows only 36 HAICDDS questions are significant
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Erratum on Practicality Assessment of the Improved ICT-based Dementia Care Mapping Support System Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-30
Yamamoto, H, Yokokohji, Y, Ishihara, T. Practicality Assessment of the Improved ICT-based Dementia Care Mapping Support System. Am. J. Alzheimer’s Dis. Other Dement. 2020;35:1-14. doi: 10.1177/1533317520935716
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Effects of Cystatin C on Cognitive Impairment in Older Chinese Adults Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-28 Zhizhen Cui; Guizhen Cao; Youyi Wang; Qinghua Ma; Congju Wang; Yong Xu; Hongpeng Sun; Yana Ma
Objective: To find a suitable dividing value to classify cystatin C and evaluate the association between cognition and levels of cystatin C. Methods: Using data from the China Health and Retirement Longitudinal Study, We conducted a longitudinal analysis of a prospective cohort of 6,869 middle-aged and older Chinese without cognitive impairment at baseline. Levels of cystatin C were categorized into
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Circulating MicroRNAs as Diagnostic Biomarkers of Clinical Cognitive Impairment: A Meta-Analysis Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-23 Dan Shi; Mengyu Han; Weilin Liu; Jing Tao; Lidian Chen
Background: Minimally invasive diagnostic biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD) facilitate patient selection and cognitive progressive decline monitoring. However, the diagnostic value of circulating microRNAs (miRNAs) for early cognitive impairment and progression to dementia is currently under debate. Thus, this study aimed to assess the diagnostic performance
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Caregivers’ Dementia Knowledge and Care Approach in Residential Aged Care Facilities in China Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-22 Yunyun Dai; Jia Zhao; Shenmei Li; Chaochao Zhao; Yan Gao; Claire Elizabeth Johnson
Objective: To investigate the dementia knowledge and care approach used by caregivers in residential aged care facilities (RACFs) in China. Method: A cross-sectional survey of 785 caregivers from a random sample of 34 RACFs in China. Caregivers’ knowledge and care approach were assessed using the Chinese version of the Dementia Knowledge Assessment Tool 2 and Advanced Dementia Care Questionnaire. Results:
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Internal Lipid Profile and Body Lipid Profile in Relation to Cognition: A Cross-Sectional Study in Southern China Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-22 Lian Liu; Xiao Huang; Liang Feng; Yanqing Wu
Aim: There are currently no established, clinically relevant, non-invasive markers of cognitive impairment, except for age and APOE genotype. Methods: A cross-sectional study of 1,296 participants from Nanchang, China, has been conducted. We collected data from Mini–Mental State Examination (MMSE) scores, internal lipid profiles and body lipid profiles, age and other factors that may have an effect
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Aphasia in Alzheimer’s Disease and Other Dementias (ADOD): Evidence From Chinese Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-12 Brendan Stuart Hackett Weekes
Speech and language impairments (aphasia) are typical of patients with Alzheimer’s Disease and other dementias (ADOD) and in some pathologies are diagnostic e.g. Primary Progressive Aphasia (PPA). One question concerns the reliability and validity of symptomatology across typologically different languages. A review of aphasia in ADOD across languages suggests a similar pattern of word comprehension
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Low Hippocampal Dentate Gyrus Volume Associated With Hypertension-Related Cognitive Impairment Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-10-12 Huagang Li; Dong Sun; Dongwei Lu; Junjian Zhang; Junjie Zeng
Hypertension increases the risk of cognitive impairment independent of detectable stroke or cerebral lesions. However, the principal pathophysiological basis of this increase has not been fully elucidated. The present study investigates the relationships among blood pressure, hippocampal subfields volume, and cognitive function in a relatively young non-stroke population. A total of 59 non-stroke non-dementia
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Observed Physical Function Is Associated With Better Cognition Among Elderly Adults: The Adventist Health Study-2 Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-30 Nicole M. Gatto; Jennifer Garcia-Cano; Crissy Irani; Tiantian Liu; Cameron Arakaki; Gary Fraser; Charles Wang; Grace J. Lee
Lifestyle factors may individually protect against the development of mild cognitive impairment. We investigate the relationships between both self-reported physical activity and measured physical function with cognition in a population of elderly adults, more than half of whom follow vegetarian dietary patterns. Otherwise healthy adults (n = 127, mean age 74.9 ± 7.9 years, 61.3% current vegetarians)
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Stress-Induced Neurodegeneration: The Potential for Coping as Neuroprotective Therapy. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-24 Shelby A Kline,Michael S Mega
Stress responses are essential for survival, but become detrimental to health and cognition with chronic activation. Chronic hypothalamic-pituitary-adrenal axis release of glucocorticoids induces hypothalamic-pituitary-adrenal axis dysfunction and neuronal loss, decreases learning and memory, and modifies glucocorticoid receptor/mineralocorticoid receptor expression. Elderly who report increased stress
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An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-24 Ana R Quiñones,Jeffrey Kaye,Heather G Allore,Anda Botoseneanu,Stephen M Thielke
Advancements in Alzheimer’s disease and related dementias (ADRD) research on the U.S. population acknowledge the importance of the high burden of ADRD on segments of the population and yet-to-be characterized risks attributable to the burden of multiple chronic diseases (multimorbidity). These realizations suggest successful strategies in caring for people with ADRD and their caregivers will rely not
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Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-24 Kalpana P Padala,Christopher M Parkes,Prasad R Padala
We present a case report to showcase that behavioral, cognitive, and functional decline may be associated with COVID-19 stay-home guidance among older adults with pre-existent cognitive impairment. In a functionally independent and physically active older adult with Mild Cognitive Impairment, there was worsening in depression and anxiety symptoms associated with the restrictions of COVID-19. Functional
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A Reliable Tool for Assessing MCI and Dementia: Validation Study of DemTect for Turkish Population. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-23 Gozde Sengul Aycicek,Hatice Çalıskan,Cemile Ozsurekci,Pelin Unsal,Josef Kessler,E Kalbe,Mert Esme,Rana Tuna Dogrul,Cafer Balcı,Umran Seven,Erdem Karabulut,Meltem Halil,Mustafa Cankurtaran,Burcu Balam Yavuz
Background and Aim: Mild cognitive impairment (MCI) and dementia prevalence are expected to increase with aging. The DemTect is a very quick and easy tool to administer and recognize the early stages of dementia and MCI. In this study we aimed to evaluate the reliability and validity of a Turkish version of the DemTect and define cut off values for different age and educational levels. One of our aims
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The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-22 Mark Maskery,Elizabeth Mary Goulding,Simon Gengler,Josefine Ulrikke Melchiorsen,Mette Marie Rosenkilde,Christian Hölscher
Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is no cure. Here, we test a dual GLP-1/GIP receptor agonist (DA4-JC) that has a cell penetrating sequence added to enhance blood-brain barrier penetration. We show in a receptor activity study that DA4-JC has balanced activity on both GLP-1 and GIP receptors but not on GLP-2 or Glucagon receptors. A dose-response study in the
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The Pupil Diameter as a Possible Indicator of Neurodegenerative Diseases and Response to Acetylcholinesterase Inhibitors Therapy: In-Depth Measurements Following Topical Administration of Tropicamide and Pilocarpine. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-09-02 Raffaele Nuzzi,Alessandro Bojino,Maria Sole Polito,Chiara Luppi,Federico Tridico,Massimiliano Massaia
Background: The aim of this study is to assess whether pupillary modifications following ocular anticholinergic and cholinergic drugs can identify subjects with neurodegenerative diseases from early stages. Methods: 51 subjects were divided into 3 groups, according to different neurodegenerative diseases, and compared with a control group of 10 patients. Pupil diameter has been measured at different
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Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-08-31 Sumeet Gupta,Anroop Nair,Vikas Jhawat,Nazia Mustaq,Abhishek Sharma,Meenakshi Dhanawat,Shah Alam Khan
Diabetes mellitus is one of the aggressive disorders in global society. No pharmacotherapy is available for permanent diabetes cure, although management is possible with drugs and physical activities. One of the recent complications noticed in type 2 diabetes mellitus includes diabetes-induced Alzheimer. It has been proposed that the possible diabetes-induced Alzheimer could be of type 3 diabetes.
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Development of Professional Care Program for Nurses in Dementia Wards and Its Educational Effects. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-08-31 Yoko Takeuchi,Mayumi Kato,Tatsuru Kitamura,Daisuke Toda,Yoshimi Taniguchi,Miho Shogenji,Hiromasa Tsujiguchi
Purpose: To develop an education program for nurses specializing in dementia care, and to investigate its effects. Methods: An intervention study of nurses was conducted using a quasi-experiment with 3 randomly assigned groups. Participants were 51 nurses from a psychiatric hospital dementia ward, divided into an intervention program group (17 nurses), a knowledge-acquisition-only group (16 nurses)
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International Development of the Alzheimer's Patient Partners Life Impact Questionnaire (APPLIQue). Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-08-27 Stephen P McKenna,Matthew Rouse,Alice Heaney,Peter Hagell
Aim: Informal caregivers play a vital role in the care of people with Alzheimer’s Disease (AD), yet caregiving is associated with caregivers’ burden. The initial objective of the study was to develop a new outcome measure to assess quality of life (QoL) in AD caregivers. Methods: Informal (non-professional) caregivers providing 75% or more of the care activities for, and living in the same household
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High School Students' Knowledge, Attitude and Preventive Practice of Dementia Care in Macao. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-08-20 Iek Long Lo,Wen Zeng,Chin Ion Lei,Chong Lam,Hong Lei Lou
Objective: To investigate knowledge, attitude and preventive practice of dementia care among high school students in Macao. Methods: Questionnaires was developed and distributed to 10 randomly selected high schools in Macao and 586 valid questionnaires were returned. Results: Knowledge, attitude and preventive practice of dementia care were 56.27 ± 24.90, 73.97 ± 7.72 and 68.34 ± 14.05. There were
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Dementia and COVID-19: The Ones Not to Be Forgotten. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-08-19 Duarte Barros,Flávia Borges-Machado,Óscar Ribeiro,Joana Carvalho
Humankind has been dealing with a devastating colossal pandemic, described as the greatest challenge of the 21st century in health and social care – dementia. Worldwide it is estimated that every 3 seconds someone develops dementia. This syndrome prevalence is not slowing down and already more than 50 million people live with it, a number that is expected to increase to 152 million in 2050.1 Supporting
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The Effect of Hormone Replacement Therapy on Cognitive Function in Female Patients With Alzheimer's Disease: A Meta-Analysis. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-17 ChengCheng Zhou,Qingguang Wu,Zongwei Wang,Qi Wang,Youya Liang,Sijun Liu
Previous studies have indicated that estrogen may delay disease progression and minimize the cognitive decline in patients with Alzheimer's disease (AD). However, the evidence for an estrogen deficiency in women with dementia and cognitive dysfunction is inconsistent. In the present review, a fixed effect meta-analysis revealed that the hormone replacement therapy (HRT) group exhibited significant
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Differential Association of Aggression With Sadness for People With Moderate and Severe Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-15 Hannah M O'Rourke,Kimberly D Fraser,Wendy Duggleby
Little is known about how individual behavioral and psychological symptoms of dementia (BPSD) impact the person with dementia. This cross-sectional, retrospective study examined the association between one BPSD, aggressive behavior, and a patient-identified outcome, sadness, among people with moderate and severe dementia (n = 5001) using clinical administrative Resident Assessment Instrument 2.0 data
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PSP-FTD Complex: A Possible Variant of PSP. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-10 Sunil Pradhan,Ruchika Tandon
Introduction: This study tried to find out type of lobar features found in patients with progressive supranuclear palsy (PSP) and whether they differ from those of frontotemporal dementia (FTD) as both of these are tauopathies. Methods: We studied lobar functions of 45 patients with PSP. Results: Five (11.1%) patients had no lobar feature; 11 (24.4%) had PSP-like features like apathy, frontal release
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Practicality Assessment of the Improved ICT-Based Dementia Care Mapping Support System. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-10 Hirotoshi Yamamoto,Yasuyoshi Yokokohji,Tetsuro Ishihara
Objectives: Authors have developed an ICT (Information-Communication Technology)-based Dementia Care Mapping (DCM™) support system and assessed its usefulness previously using videos. The aim of this study is to evaluate practicality of the improved support system by actual mapping. Methods: We obtained highly reliable mapping data by a team of 3 mappers (M1, M2, and M3), who mapped 5 elderly people
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An Automated Approach to Examining Pausing in the Speech of People With Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-10 Rachel A Sluis,Daniel Angus,Janet Wiles,Andrew Back,Tingting Amy Gibson,Jacki Liddle,Peter Worthy,David Copland,Anthony J Angwin
Dementia is a common neurodegenerative condition involving the deterioration of cognitive and communication skills. Pausing in the speech of people with dementia is a dysfluency that may be used to signal conversational trouble in social interaction. This study aimed to examine the speech-pausing profile within picture description samples from people with dementia and healthy controls (HCs) within
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New-Onset Alzheimer's Disease and Normal Subjects 100% Separated Statistically by P300 and ICA. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-07 Barrie William Jervis,Cristin Bigan,Mircea Besleaga
Previously, we described how patients with new-onset Alzheimer’s disease were differentiated from healthy, normal subjects to 100% accuracy, based on the amplitudes of the nonrhythmic back-projected independent components of the P300 peak at the electroencephalogram electrodes and their latency in the response to an oddball, auditory evoked potential paradigm. A neural network and a voting strategy
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The Swinging Self: The Costs of Shifting Between Self-Images in Alzheimer's Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-07-06 Emin Altintas,Ahmed A Moustafa,Karim Gallouj,Mohamad El Haj
Background: We investigated the ability of patients with Alzheimer’s disease (AD) to shift between different self-images. Methods: We developed an original task (shifting-self task) in which we invited 28 patients with AD and 30 control participants to generate “who am I” statements that describe 2 alternative self-images (ie, physical-self vs psychological-self). In a control task, participants had
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Machine-Learning Algorithms Based on Screening Tests for Mild Cognitive Impairment. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-30 Jin-Hyuck Park
Background: The mobile screening test system for mild cognitive impairment (mSTS-MCI) was developed and validated to address the low sensitivity and specificity of the Montreal Cognitive Assessment (MoCA) widely used clinically. Objective: This study was to evaluate the efficacy machine learning algorithms based on the mSTS-MCI and Korean version of MoCA. Method: In total, 103 healthy individuals and
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Longitudinal Sensitivity of Alzheimer's Disease Severity Staging. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-23 Julia S Benoit,Wenyaw Chan,Linda Piller,Rachelle Doody
Understanding Alzheimer’s disease (AD) dynamics is essential in diagnosis and measuring progression for clinical decision-making; however, clinical instruments are imperfect at classifying true disease stages. This research evaluates sensitivity and determinants of AD stage changes longitudinally using current classifications of “mild,” “moderate,” and “severe” AD, using Mini-Mental State Examination
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Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-22 Chengping Hu,Ling Wang,Yi Guo,Zhicheng Cao,Ying Lu,Hongyun Qin
Objective: To evaluate the risk factors for progress of mild cognitive impairment to dementia. Methods: This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and
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In Response to a Letter to the Editor "Frontotemporal Dementia and Suicide; Could Genetics be a Key Factor?" Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-15 Milena Zucca,Elisa Rubino,Alessandro Vacca,Flora Govone,Annalisa Gai,Paola De Martino,Silvia Boschi,Innocenzo Rainero
We thank Dr Fremont et al for their interest in our findings1 and for calling attention to some aspects that may need further explanation.
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Neuroprotective Properties and Therapeutic Potential of Bone Marrow-Derived Microglia in Alzheimer's Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-15 Chang Li,Yu-Hua Chen,Ke Zhang
Alzheimer’s disease (AD) is the most common form of dementia, which is characterized by a progressive cognitive decline and senile plaques formed by amyloid β (Aβ). Microglia are the immune cells of the central nervous system (CNS). Studies have proposed 2 types of microglia, namely, the resident microglia and bone marrow–derived microglia (BMDM). Recent studies suggested that BMDM, not the resident
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Frontotemporal Dementia and Suicide; Could Genetics be a Key Factor? Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-10 Rachel Fremont,Jordan Grafman,Edward D Huey
Frontotemporal dementia (FTD) is a neurodegenerative syndrome characterized by degenerative changes in behavior, executive function, and/or language that are accompanied by volume loss in frontal and anterior temporal brain regions.1 Neuropsychiatric symptoms are a prominent feature of this disorder and can include apathy, behavioral disinhibition, loss of empathy, compulsive behaviors, and others
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"What" and "How": A New Perspective for Understanding Unawareness in Alzheimer's Disease Through a Combination of Two Perspectives. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-06-08 Amandine Mayelle,Mohamad El Haj,Pascal Antoine
Objectives: Assessments of unawareness in Alzheimer’s disease mainly focus on the objects (the “what”) of unawareness. A recent person-centered approach proposes to also assess the processes (the “how”). The present study combines 2 approaches to understand this heterogeneity in assessments of unawareness. Method: We recruited 46 participants from 8 nursing homes. They underwent a semi-structured interview
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Risk Factors for Cardiovascular Events in Patients on Antidementia Medications. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-05-08 Meiqi He,James M Stevenson,Yuting Zhang,Inmaculada Hernandez
OBJECTIVE To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications. METHODS Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate
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Association Between Subjective Cognitive Decline and Social and Emotional Support in US Adults. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-05-05 Xingran Weng,Daniel R George,Bibo Jiang,Li Wang
Subjective cognitive decline (SCD) has been linked to Alzheimer's Disease in the literature. However, little is known about whether SCD is associated with social/emotional support (SES). To investigate this association, this study utilized the 2015 and 2016 Behavioral Risk Factor Surveillance System data. A study population of 17206 participants aged 45 years and older who responded to both the Emotional
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A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-05-01 Valeria Isella,Cristina Rosazza,Maria Gazzotti,Jessica Sala,Sabrina Morzenti,Cinzia Crivellaro,Ildebrando Marco Appollonio,Carlo Ferrarese,Claudio Luzzatti
Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced in a picture-naming test by 63
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Evaluating Semantic Knowledge Through a Semantic Association Task in Individuals With Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-04-20 Claudio Luzzatti,Ilaria Mauri,Stefania Castiglioni,Marta Zuffi,Chiara Spartà,Francesco Somalvico,Massimo Franceschi
Conceptual knowledge is supported by multiple semantic systems that are specialized for the analysis of different properties associated with object concepts. Various types of semantic association between concrete concepts-categorical (CA), encyclopedic (EA), functional (FA), and visual-encyclopedic (VEA) associations-were tested through a new picture-to-picture matching task (semantic association task
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Whole-Blood Levels of MicroRNA-9 Are Decreased in Patients With Late-Onset Alzheimer Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-04-17 Vinicius Carolino Souza,Gilberto Santos Morais,Adriane Dallanora Henriques,Wilcelly Machado-Silva,Diego Ignacio Valenzuela Perez,Ciro José Brito,Einstein Francisco Camargos,Clayton Franco Moraes,Otávio Toledo Nóbrega
Recent evidence suggests changes in circulating microRNA levels may be promising biomarkers for the clinical diagnosis of Alzheimer disease (AD). We hypothesized that whole-blood microRNAs may be useful to identify individuals with established AD. For this purpose, a sample of community-dwelling women (≥55 years old) carrying the ApoE ∊4 allele were clinically evaluated using the American Psychiatric
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Loneliness and Burden Perceived by Family Caregivers of Patients With Alzheimer Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-04-13 Verena Bramboeck,Korbinian Moeller,Josef Marksteiner,Liane Kaufmann
BACKGROUND The present study aimed at investigating loneliness and burden experienced by family members caring for relatives diagnosed with Alzheimer disease. METHODS Participants were 40 caregivers of inpatients with Alzheimer disease. Correlation and multiple regression analyses were conducted to investigate whether caregivers' loneliness (uni- and multidimensional) and burden are associated with
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Addressing Behavioral Symptoms of Dementia Through STAR-VA Implementation: Do Outcomes Vary by Behavior Type? Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-04-02 Jenefer M Jedele,Kim Curyto,Brian M Ludwin,Michele J Karel
OBJECTIVES The STAR-VA program in Veterans Health Administration Community Living Centers (CLCs, nursing home settings) trains teams to implement a psychosocial intervention with residents with behavioral symptoms of dementia (BSD). METHODS Across 71 CLCs, 302 residents selected as training cases had target behaviors categorized into one of 5 types: physically aggressive (PA), physically nonaggressive
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How Evidence-Based Practice (E3BP) Informs Speech-Language Pathology for Primary Progressive Aphasia. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-03-30 Leanne Ruggero,Karen Croot,Lyndsey Nickels
Amelioration of communication impairment in primary progressive aphasia (PPA) is an area of clinical importance and current research. Speech-language pathologists (SLPs) have a range of skills and interventions to support communication in PPA; however, underrecognition of their role and low referral rates is an ongoing concern. The E3BP conceptualization of evidence-based practice comprises 3 components:
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Insulin Resistance Is Independently Associated With Enlarged Perivascular Space in the Basal Ganglia in Nondiabetic Healthy Elderly Population. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-03-17 Danhong Wu,Xiaoli Yang,Ping Zhong,Xiaofei Ye,Chen Li,Xueyuan Liu
OBJECTIVES To investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population. METHODS A total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. The homeostasis model assessment-estimated insulin resistance index (HOMA-IR) was used for
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Antidiabetic Drugs for the Risk of Alzheimer Disease in Patients With Type 2 DM Using FAERS. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-03-12 Hayato Akimoto,Akio Negishi,Shinji Oshima,Haruna Wakiyama,Mitsuyoshi Okita,Norimitsu Horii,Naoko Inoue,Shigeru Ohshima,Daisuke Kobayashi
Alzheimer disease (AD) may develop after the onset of type 2 diabetes mellitus (T2DM), and the risk of AD may depend on the antidiabetic drug administered. We compared the risk of AD among 66 085 patients (≥ 65 years) with T2DM (1250 having concomitant AD) who had been administered antidiabetic drug monotherapy for T2DM who had voluntarily reported themselves in the Food and Drug Administration Adverse
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Combined Influences of Dementia Exposure and Personality on Self-Reported Memory Problems. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-03-12 Jacqueline Mogle,Nikki L Hill,Tyler Reed Bell,Sakshi Bhargava,Emily Bratlee-Whitaker,Rachel K Wion,Pooja Anushka Tiwari
The current study investigated whether having a first-degree relative with dementia influenced older adults' self-reported memory, if personality traits moderated these associations, and whether these associations differed by the type of item asked (ie, frequency of memory problems vs perceived memory decline). Data drawn from the Einstein Aging study included 454 older adults (M age = 76.64, standard
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BESI: Behavioral and Environmental Sensing and Intervention for Dementia Caregiver Empowerment-Phases 1 and 2. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-03-12 Azziza Bankole,Martha S Anderson,Nutta Homdee,Ridwan Alam,Ashley Lofton,Nykesha Fyffe,Hilda Goins,Temple Newbold,Tonya Smith-Jackson,John Lach
BACKGROUND AND OBJECTIVES Caregiver burden associated with dementia-related agitation is one of the commonest reasons a community-dwelling person with dementia (PWD) transitions to a care facility. Behavioral and Environmental Sensing and Intervention for Dementia Caregiver Empowerment (BESI) is a system of body-worn and in-home sensors developed to provide continuous, noninvasive agitation assessment
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Primary Progressive Aphasia Education and Support Groups: A Clinical Evaluation. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-25 Cathleen Taylor-Rubin,Lisa Azizi,Karen Croot,Lyndsey Nickels
OBJECTIVES To evaluate the benefits of a primary progressive aphasia (PPA) education and support session for people with PPA (pwPPA) and their caregivers. METHOD Thirty-eight individuals (20 pwPPA, 18 caregivers) were invited to participate in the study. Twenty-five individuals (12 pwPPA, 13 caregivers) completed questionnaires before and after an education and support group session provided by a speech
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Nutritional and Functional Indicators and Their Association With Mortality Among Older Adults With Alzheimer's Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-24 O Vicente de Sousa,J Mendes,T F Amaral
This study investigated how different nutritional and functional status indicators are associated with mortality in patients with Alzheimer's disease (AD). A prospective cohort study was conducted among 79 community-dwelling older adults with AD. Follow-up was 60 months. Undernutrition status was evaluated by Mini Nutritional Assessment (MNA), body mass index, mid-arm muscle circumference (MAMC), calf
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Caregiver Psychological Distress: Longitudinal Relationships With Physical Activity and Diet. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-17 Shane A Snyder,Peter P Vitaliano
Given limited longitudinal research with caregivers (CGs, n = 122) of spouses with Alzheimer disease, and demographically matched noncaregivers (NCGs, n = 117), we compared these groups on psychological distress (anxiety, depression), burden, and health behaviors over 2 years. Analyses examined group differences in relationships of micronutrient recommended daily allowances (RDAs) and physical activity
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Anxiety and Depression Are Not Related to Increasing Levels of Burden and Stress in Caregivers of Patients With Alzheimer's Disease. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-13 Tiziana Tentorio,Sharon Dentali,Camilla Moioli,Marta Zuffi,Rosy Marzullo,Stefania Castiglioni,Massimo Franceschi
Sixty-nine dyads of patients with Alzheimer's disease and primary caregivers have been followed up for 1 year to evaluate cognitive (Mini-Mental State Examination), functional (Instrumental Activities of Daily Living), and behavioral (Neuropsychiatric Inventory) decline of patient in relation to burden (Caregiver Burden Inventory), stress (Relative Stress Scale), anxiety (State-Trait Anxiety Inventory
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Disclosure of Amyloid Status for Risk of Alzheimer Disease to Cognitively Normal Research Participants With Subjective Cognitive Decline: A Longitudinal Study. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-13 Taisei Wake,Hajime Tabuchi,Kei Funaki,Daisuke Ito,Bun Yamagata,Takahito Yoshizaki,Tadaki Nakahara,Masahiro Jinzaki,Haruo Yoshimasu,Iori Tanahashi,Hiroumi Shimazaki,Masaru Mimura
This study aimed to investigate the long-term impacts of disclosing amyloid status for a risk of Alzheimer disease (AD) to cognitively normal research participants with subjective cognitive decline (SCD), which represents an initial manifestation of AD. Forty-two participants were classified as the amyloid-positive (n = 10) or amyloid-negative (n = 32) groups. We assessed symptoms of anxiety, depression
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Determining Middle-Aged and Older Adults' Health Beliefs to Change Lifestyle and Health Behavior for Dementia Risk Reduction. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-12 Merve Aliye Akyol,Lemye Zehirlioğlu,Merve Erünal,Hatice Mert,Nur Şehnaz Hatipoğlu,Özlem Küçükgüçlü
BACKGROUND Global population is getting older and the prevalence of dementia continuously increases. Understanding the related health beliefs is bound to enable lifestyle-based interventions that maximize public engagement in dementia risk reduction behaviors. The aim of this study was to determine health beliefs on dementia prevention behaviors and lifestyle changes and to determine the factors influencing
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Reduction of Amyloid in the Brain and Retina After Treatment With IVIG for Mild Cognitive Impairment. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-02-12 Shawn Kile,William Au,Carol Parise,Jaideep Sohi,Tracy Yarbrough,Alan Czeszynski,Ken Johnson,Dan Redline,Tammy Donnel,Andrea Hankins,Kimberley Rose
OBJECTIVE To assess whether intravenous immunoglobulin (IVIG) in subjects with mild cognitive impairment (MCI) results in a reduction in amyloid in the central nervous system (CNS). METHODS Five subjects with MCI underwent baseline Florbetapir positron emission tomography and retinal autofluorescent imaging. All were administered IVIG (Octagam 10%) at 0.4 g/kg every 14 days for a total of 5 infusions
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Effect of Self-Efficacy on Quality of Life in People With Mild Cognitive Impairment and Mild Dementia: The Mediating Roles of Depression and Anxiety. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-01-09 Johanne B Tonga,Dag-Erik Eilertsen,Ingrid K Ledel Solem,Espen A Arnevik,Maria S Korsnes,Ingun D Ulstein
OBJECTIVES To examine the mediating effects of depression and anxiety in the relationship between self-efficacy and quality of life among people with mild cognitive impairment (MCI) or mild dementia. METHOD A total of 196 patients diagnosed with MCI or dementia due to Alzheimer disease completed structured measures of self-efficacy, quality of life, and depressive and anxiety symptoms. We examined
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Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2020-01-06 Hong Wang,Xiangrong Shi,Hannah Schenck,James R Hall,Sarah E Ross,Geoffrey P Kline,Shande Chen,Robert T Mallet,Peijie Chen
Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT's safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O2 and room-air, each 5 minutes, for 8 cycles/session, 3 sessions/wk
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The Turkish Version of the Telephone Cognitive Screen for Detecting Cognitive Impairment in Older Adults. Am. J. Alzheimers Dis. Other Demen. (IF 1.544) Pub Date : 2019-11-22 Mehmet Ilkin Naharci,Fatih Celebi,Ekin Oktay Oguz,Osman Yilmaz,Ilker Tasci
The ability to screen Turkish-speaking older adults for cognitive impairment by phone is lacking. The aim of this study was to translate th