Changing the speed, size and material properties of optic flow can significantly alter the experience of vection (i.e. visually induced illusions of self-motion). Until now, there has not been a systematic investigation of the effects of luminance contrast, averaged luminance and stimulus spatial frequency on vection. This study examined the vection induced by horizontally oriented gratings that continuously

Sustained limb motor activity has been used as a therapeutic tool for improving rehabilitation outcomes and is thought to be mediated by neuroplastic changes associated with activity-induced cortical excitability. Although prior research has reported enhancing effects of continuous chewing and swallowing activity on learning, the potential beneficial effects of sustained oromotor activity on speech

The rubber hand illusion is a perceptual illusion in which participants experience an inanimate rubber hand as their own when they observe this model hand being stroked in synchrony with strokes applied to the person’s real hand, which is hidden. Earlier studies have focused on the factors that determine the elicitation of this illusion, the relative contribution of vision, touch and other sensory

Single cutaneous fibers were recorded in the median nerve of the deeply anesthetized rat and the receptor morphology in the forelimb glabrous skin was analyzed to establish a probable correlation between receptor anatomy and physiology. Receptor complexes in the glabrous skin of the rat forelimb were stained immunologically with antibodies NF-200 and PGP-9.5, confirming the presence of Meissner corpuscles

Switching between two or more tasks is a key component in our modern world. Task switching, however, requires time-consuming executive control processes and thus produces performance costs when compared to task repetitions. While executive control during task switching has been associated with activation in the lateral prefrontal cortex (lPFC), only few studies so far have investigated the causal relation

The nociceptive withdrawal reflex (NWR) threshold is commonly employed in the lower limb to assess clinical and experimentally induced pain. However, no studies to date have investigated changes in spinal nociception in the upper limb, via the NWR threshold, following experimentally induced central sensitization (CS). We tested the hypothesis that experimentally induced CS of the C5–C6 spinal segment

Our objective of this study is to determine the molecular mechanism of MAPKs (mitogen activated protein kinase systems) on TRPV4 (transient receptor potential vanilloid 4)-mediated trigeminal neuralgia (TN). Partial chronic constriction injury of the infraorbital nerve (CCI-ION) ligation model was used in this research. When treated with antagonists of p38, JNK or ERK, the mechanical hyperalgesia threshold

Participation in physical activity benefits brain health and function. Cognitive function generally demonstrates a noticeable effect of physical activity, but much less is known about areas responsible for controlling movement, such as primary motor cortex (M1). While more physical activity may support M1 plasticity in older adults, the neural mechanisms underlying this beneficial effect remain poorly

It is known that movements of visual attention are influenced by features in a scene, such as colors, that are associated with value or with loss. The present study examined the detailed nature of these attentional effects by employing the gap paradigm—a technique that has been used to separately reveal changes in attentional capture and shifting, and changes in attentional disengagement. In four experiments

The present study aimed to separate the neural activities between response inhibition and memory updating processes in the Count/Nocount task. Memory load was manipulated to investigate the memory updating process. Within each trial, participants were asked to count/withhold counting the number of O/X letters in the Count/Nocount task. The participants were asked to silently add 1 if a Count letter

The sense of position of the body and its limbs is a proprioceptive sense. Proprioceptors are concerned with monitoring the body’s own actions. Position sense is important because it is believed to contribute to our self-awareness. This review discusses recent developments in the debate about the sources of peripheral afferent signals contributing to position sense and describes different methods of

The visual system is said to be especially sensitive towards spatial but lesser so towards temporal information. To test this, in two experiments, we systematically reduced the acuity and contrast of a visual stimulus and examined the impact on spatial and temporal precision (and accuracy) in a manual interception task. In Experiment 1, we blurred a virtual, to-be-intercepted moving circle (ball).

Depression is a complex etiological disease with limited effective treatments. Previous studies have indicated the involvement of miRNAs in the pathophysiology of mood disorders. In this study, we focused on the role and mechanisms of miR-129-5p in depression by successfully constructing mice models of depressive-like behavior via chronic unpredictable mild stress (CUMS) exposure. Herein, miR-129-5p

The purpose of this study was to determine whether the application of lateral pelvis pulling force toward the non-paretic side during the stance phase of the paretic leg would enhance forced use of the paretic leg and increase weight shift toward the paretic side in stroke survivors. Eleven chronic stroke survivors participated in two experimental sessions, which consisted of (1) treadmill walking

Neurophysiological experiments using transcranial magnetic stimulation (TMS) have sought to probe the function of the motor division of the corpus callosum. Primary motor cortex sends projections via the corpus callosum with a net inhibitory influence on the homologous region of the opposite hemisphere. Interhemispheric inhibition (IHI) experiments probe this inhibitory pathway. A test stimulus (TS)

To investigate the association of miR-106b-5p with neuroinflammation and microglial activation in a status epilepticus (SE) mouse model. We examined changes in the expression of microRNA-106b-5p (miRNA-106b-5p), repulsive guidance molecule A (RGMa), triggering receptor expressed on myeloid cells 2 (TREM2), and the microglia-related markers interleukin (IL)-1β, IL-4, IL-6, IL-10, inducible nitric oxide

The purpose of this study is to clarify that exercise may improve the motor dysfunction of Parkinson’s disease (PD) model rats by increasing the reuptake of glutamate (Glu) in the striatum. The neurotoxin 6-hydroxydopamine (6-OHDA) was injected into the medial forebrain bundle (MFB) of the rats’ right brain to establish PD model rats with unilateral injury, and the sham operation group was given the

Eye movements that are dependent on cognition hold promise in assessing sports-related concussions but research on reliability of eye tracking measurements in athletic cohorts is very limited. This observational test–retest study aimed to establish whether eye tracking technology is a reliable tool for assessing sports-related concussions in youth and adult athletes partaking in contact and collision

In virtual reality (VR), immersion can be created through synchronous visuomotor stimulations and enhanced by adding auditory or kinesthetic stimulations. Multiple patterned vibrations applied at the lower limbs might be a way to induce kinesthetic perception of gait motion that could be combined with VR stimulations to add the perception of self-motion. However, gait motion perception using multiple

The mesopontine tegmental anesthesia area (MPTA) was identified in rats as a singular brainstem locus at which microinjection of minute quantities of GABAergic agents rapidly and reversibly induces loss-of-consciousness and a state of general anesthesia, while lesioning renders animals insensitive to anesthetics at normal systemic doses. Obtaining similar results in mice has been challenging, however

Previous studies have shown that reinforcement-based motor learning requires the brain to process feedback-related information after movement execution. However, whether reinforcement feedback changes how the brain processes motor preparation before movement execution is unclear. By using electroencephalography (EEG), this study investigates whether reinforcement feedback changes cortical preparatory

Inhibitory control, the ability to suppress irrelevant thoughts or actions, is central to cognitive and social development. Protracted maturation of frontal brain networks has been reported as a major restraint for this ability, yet, young children, when motivated, successfully inhibit delayed responses. A better understanding of the age-dependent neural inhibitory mechanism operating during the awaiting-to-respond

Lightness contrast and assimilation are opposite phenomena: in contrast grey targets appear darker when bordering bright rather than dark surfaces; in assimilation grey targets appear lighter when bordering bright rather than dark surfaces. The underlying neurophysiological mechanisms of these phenomena are not known. The aim of this study was to investigate the relationship between contrast and assimilation

Modifying established motor skills is a challenging endeavor due to proactive interference from undesired old to desired new actions, calling for high levels of cognitive control. Motor restrictions may facilitate the modification of motor skills by rendering undesired responses physically impossible, thus reducing demands to response inhibition. Here we studied behavioral and EEG effects of rule changes

There is a steadily growing number of mobile communication systems that provide spatially encoded tactile information to the humans’ torso. However, the increased use of such hands-off displays is currently not matched with or supported by systematic perceptual characterization of tactile spatial discrimination on the torso. Furthermore, there are currently no data testing spatial discrimination for

Recent evidences suggest that binaural vestibular stimulation affects tactile temporal processing. However, it remains difficult to determine the physiological mechanisms supporting the vestibular–somatosensory interactions observed during a TOJ task. Controlling the activation of the right or left vestibular system separately could allow to better understand the physiological bases of these findings

This study investigated evoked and oscillatory brain activity in response to forward visual motion at three different ecologically valid speeds, simulated through an optic flow pattern consisting of a virtual road with moving poles at either side of it. Participants were prelocomotor infants at 4–5 months, crawling infants at 9–11 months, primary school children at 6 years, adolescents at 12 years

The human brain creates an external world representation based on magnitude judgments by estimating distance, numerosity, or size. The magnitude and spatial representation are hypothesized to rely on common mechanisms shared by different sensory modalities. We explored the relationship between magnitude and spatial representation using two different sensory systems. We hypothesize that the interaction

Previous studies have proposed that holding soft objects can increase expectations to be included in a Cyberball task. The present study investigated whether effects of holding soft objects on expectations are restricted to social contexts or can appear in non-social contexts. Sixty-six participants performed a social or non-social ball task, both modified versions of the Cyberball task. In the social

People react faster to visuo-tactile stimuli presented near the body (i.e., in peripersonal space) than to tactile stimuli presented alone. This multi-sensory facilitation effect has been used as a measurement of peripersonal space. Previous research has reported that peripersonal space representations can be modulated by actively using hand-held tools or disconnected hand avatars. However, previous

When lifting or moving a novel object, humans are routinely able to quickly characterize the nature of the unknown load and swiftly achieve the desired movement trajectory. It appears that both tactile and proprioceptive feedback systems help humans develop an accurate prediction of load properties and determine how associated limb segments behave during voluntary movements. While various types of

We revisit the concept of synergy based on the recently translated classical book by Nikolai Bernstein (On the construction of movements, Medgiz, Moscow 1947; Latash, Bernstein’s Construction of Movements, Routledge, Abingdon 2020b) and progress in understanding the physics and neurophysiology of biological action. Two aspects of synergies are described: organizing elements into stable groups (modes)

Transcranial magnetic stimulation (TMS) is used to investigate corticomotor neurophysiology associated with functional recovery in individuals with spinal cord injury (SCI). There is insufficient evidence about test–retest measurement properties of TMS in SCI. Therefore, we investigated test–retest agreement and reliability of TMS metrics representing corticomotor excitability, output, gain, map (representation)

It is debated whether the representation of numbers is endowed with a directional-spatial component so that perceiving small-magnitude numbers triggers leftward shifts of attention and perceiving large-magnitude numbers rightward shifts. Contrary to initial findings, recent investigations have demonstrated that centrally presented small-magnitude and large-magnitude Arabic numbers do not cause leftward

Previously, we reported that distal Schaffer collaterals undergo biphasic changes in excitability during high-frequency stimulation (HFS), with an early hyper-excitability period followed by an excitability depression period. The extracellular divalent cations calcium and magnesium can regulate membrane excitability in neuronal tissue. Therefore, we hypothesized that altering the concentrations of

Two rhythmic coordinations, 0° and 180° relative phase, can be performed stably at preferred frequency (~ 1 Hz) without training. Evidence indicates that both 0° and 180° coordination entail detection of the relative direction of movement. At higher frequencies, this yields instability of 180° and spontaneous transition to 0°. The ability to perform a 90° coordination can be acquired by learning to

Although voluntary muscle contraction modulates spinal reflex excitability of contracted muscles and other muscles located at other segments within a limb (i.e., intra-limb modulation), to what extent corticospinal pathways are involved in intra-limb modulation of spinal reflex circuits remains unknown. The purpose of the present study was to identify differences in the involvement of corticospinal

Virtual reality head mounted display (VR HMD) systems are increasingly utilised in combination with electroencephalography (EEG) in the experimental study of cognitive tasks. The aim of our investigation was to determine the similarities/differences between VR HMD and the computer screen (CS) in response to an n-back working memory task by comparing visual electrophysiological event-related potential

Recent animal and human studies connected the Morc family CW-type zinc finger 1 (Morc1) gene with early life stress and depression. Moreover, the Morc superfamily is related to epigenetic regulation in diverse nuclear processes. So far, the Morc1 gene was mainly studied in spermatogenesis, whereas its distribution and function in the brain are still unknown. In a first attempt to characterize Morc1

Traumatic brain injury (TBI) is one of the main causes of death and disability in both civilian and military population. TBI may occur via a variety of etiologies, all of which involve trauma to the head. However, the neuroprotective drugs which were found to be very effective in animal TBI models failed in phase II or phase III clinical trials, emphasizing a compelling need to review the current status

The purpose of this study was to determine the form of the relation between the mean amplitude and variance of motor-evoked potentials (MEP). To this end, single-pulse transcranial magnetic stimulation (TMS) was applied over the motor cortex of seventeen neurologically normal adult human subjects. The coil was positioned at a locus on the scalp that elicited an MEP in the first dorsal interosseous

Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that causes neuronal growth cones to collapse and neurites to retract through a RhoA-ROCK mediated pathway. It has been reported that the NSAID ibuprofen improves regeneration after spinal cord injury through a mechanism of inhibiting RhoA. This leads to the hypothesis that ibuprofen should block LPA-mediated growth cone collapse. We tested

A rapid increase in the number of patients with Alzheimer’s disease (AD) is expected over the next decades. Accordingly, there is a critical need for early-stage AD detection methods that can enable effective treatment strategies. In this study, we consider the ability of episodic-memory measures to predict mild cognitive impairment (MCI) to AD conversion and thus, detect early-stage AD. For our analysis

We explored the organization of motor units recorded in the flexor digitorum superficialis into stable groups (MU-modes) and force-stabilizing synergies in spaces of MU-modes. Young, healthy participants performed one-finger and three-finger accurate cyclical force production tasks. Two wireless sensor arrays (Trigno Galileo, Delsys, Inc.) were placed over the proximal and distal portions of the muscle

Infants acquire the ability to roll over from the supine to the prone position, which requires body coordination of multiple degrees of freedom under dynamic interactions with the ground. Although previous studies on infant rolling observed kinematic characteristics, little is known about the kinetic characteristics of body segments in contact with the surface. We measured the ground contact pressure

Subpopulations of primary nociceptors (C- and Aδ-fibers), express the TRPV1 receptor for heat and capsaicin. During cutaneous inflammation, these afferents may become sensitized, leading to primary hyperalgesia. It is known that TRPV1+ nociceptors are involved in heat hyperalgesia; however, their involvement in mechanical hyperalgesia is unclear. This study explored the contribution of capsaicin-sensitive

Sensorimotor adaptation can involve multiple learning processes with different time courses, and these processes may have different patterns of transfer. In this study, we tested how slow learning and fast learning transfer across tasks, and the specificity of transfer. We tested two natural goal-directed tasks: pointing and walking toward a visible target. We also tested a novel “hand locomotion”

Cancellation tasks have been widely used to neurologically assess selective attention and visual search in various clinical and research settings. However, there is still a lack of evidence regarding the effect of the level of task difficulty on brain activity in the prefrontal cortex (PFC). This study implemented cancellation tasks to investigate the effects of varying task difficulty on oxygenated

Insulin deficiency or resistance can promote dementia and hallmarks of Alzheimer's disease (AD). The formation of neurofibrillary tangles of p-TAU protein, extracellular Aβ plaques, and neuronal loss is related to the switching off insulin signaling in cognition brain areas. Metformin is a biguanide antihyperglycemic drug used worldwide for the treatment of type 2 diabetes. Some studies have demonstrated

Phoenixin-14 (PNX-14) has a wide bioactivity in the central nervous system. Its role in the hypothalamus has been investigated, and it has been reported that it is involved in the regulation of excitability in hypothalamic neurons. However, its role in the regulation of excitability in entorhinal cortex and the hippocampus is unknown. In this study, we investigated whether i. PNX-14 induces any synchronous

The cerebral integration of somatosensory inputs from multiple sources is essential to produce adapted behaviors. Previous studies suggest that bilateral somatosensory inputs interact differently depending on stimulus characteristics, including their noxious nature. The aim of this study was to clarify how bilateral inputs evoked by noxious laser stimuli, noxious shocks, and innocuous shocks interact

It is commonly accepted that the brains capacity to change, known as plasticity, declines into old age. Recent studies have used a variety of non-invasive brain stimulation (NIBS) techniques to examine this age-related decline in plasticity in the primary motor cortex (M1), but the effects seem inconsistent and difficult to unravel. The purpose of this review is to provide an update on studies that

After hindlimb unloading (HU), the adaptive changing of the rat step cycle duration, kinematics of the ankle and knee joints, and duration of one-joint ankle extensor m. soleus (SOL) activity are detected. However, how the activity of their synergist gastrocnemius medialis muscle (GM) changes in locomotion after HU remains unknown. GM is a two-joint muscle that produces both extension and flexion torques

Nowadays a popular technique to improve mood and cognition is auditory beat stimulation (ABS), which is thought to induce a frequency-following response of brainwaves. The main types of ABS are monaural beats (MB) and binaural beats (BB). BB involves the presentation of a specific frequency to one ear and another frequency to the other ear which may induce neural entrainment. A difference between the

Analysing a visual scene requires the brain to briefly keep in memory potentially relevant items of that scene and then direct attention to their locations for detailed processing. To reveal the neuronal basis of the underlying working memory and top-down attention processes, we trained macaques to match two patterns presented with a delay between them. As the above processes are likely to require

This study explored the relationship between single motor unit (MU) firing rates (FRs) and limb movement velocity during voluntary shortening contractions when accounting for the effects of time course variability between different kinematic comparisons. Single MU trains recorded by intramuscular electromyography in agonist muscles of the anconeus (n = 15 participants) and lateral head of the triceps

Binaural beat (BB) is a promising technique for memory improvement in elderly or people with neurological conditions. However, the related modulation of cortical networks followed by behavioral changes has not been investigated. The objective of this study is to establish a relationship between BB oscillatory brain activity evoked by stimulation and a behavioral response in a short term memory task

Motion perception deficits in dyslexia show a large intersubjective variability, partly reflecting genetic factors influencing brain architecture development. In previous work, we have demonstrated that dyslexic carriers of a mutation of the DCDC2 gene have a very strong impairment in motion perception. In the present study, we investigated structural white matter alterations associated with the poor

To investigate the role of GluN2A and GluN2B in neuroprotective effect of sevoflurane preconditioning against cerebral ischemia–reperfusion injury (CIRI). Rats were randomly divided into five groups as follows: control, ischemia–reperfusion (I/R) 6 h, sevoflurane preconditioning (SP), SP + amantadine, SP + NMDA. Immunoblot and immunoprecipitation were used to detect the tyrosine phosphorylation of

Working memory (WM)—the ability to keep information in mind for short periods of time—is linked to attention and inhibitory abilities, i.e., the capacity to ignore task-irrelevant information. These abilities have been associated with brain oscillations, especially parietal gamma and alpha bands, but it is yet unknown whether these oscillations also modulate attention and inhibitory abilities. To test