-
Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1α knockout rats BMC Neurosci. (IF 2.4) Pub Date : 2024-03-15 Samuel Marashli, Philipp Janz, Roger L Redondo
Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. There is, however, a limited understanding of ABRs as tools to assess the effect of pharmacological interventions. Therefore, we set out to understand how pharmacological agents that target key transmitter systems of the auditory brainstem circuitry affect ABRs in rats. Given previous
-
Serum interleukin-17 A and homocysteine levels in children with autism BMC Neurosci. (IF 2.4) Pub Date : 2024-03-12 Hui Li, Yunhao Dang, Ying Yan
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that typically emerges early in childhood. This study aimed to explore the potential link between serum levels of vitamin B12 and homocysteine (Hcy) and the severity of ASD symptoms in children. In this study, 50 children diagnosed with ASD comprised the observation group, while 50 healthy children constituted the control group. Serum
-
Administration methods and dosage of poly(lactic acid)-glycol intervention to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalitis mice BMC Neurosci. (IF 2.4) Pub Date : 2024-03-11 Amy E. Wright, Shuhei Nishiyama, Patrick Han, Philip Kong, Michael Levy
Myelin oligodendrocyte glycoprotein-associated disorders (MOGAD) is an autoimmune central nervous system disease. Antigen-specific immune tolerance using nanoparticles such as Polylactic-co-glycolic acid (PLGA) have recently been used as a new therapeutic tolerization approach for CNS autoimmune diseases. We examined whether MOG1-125 conjugated with PLGA could induce MOG-specific immune tolerance in
-
Discrimination of the moving direction is improved depending on the pattern of the mechanical tactile stimulation intervention BMC Neurosci. (IF 2.4) Pub Date : 2024-03-05 Yuki Maruyama, Sho Kojima, Hideaki Onishi
The mechanical tactile stimulation, such as plastic pins and airflow-driven membrane, induces cortical activity. The cortical activity depends on the mechanical tactile stimulation pattern. Therefore, the stimulation pattern of mechanical tactile stimuli intervention may influence its effect on the somatosensory function. However, the effect of the mechanical tactile stimulation input pattern on the
-
State-transition dynamics of resting-state functional magnetic resonance imaging data: model comparison and test-to-retest analysis BMC Neurosci. (IF 2.4) Pub Date : 2024-03-04 Saiful Islam, Pitambar Khanra, Johan Nakuci, Sarah F. Muldoon, Takamitsu Watanabe, Naoki Masuda
Electroencephalogram (EEG) microstate analysis entails finding dynamics of quasi-stable and generally recurrent discrete states in multichannel EEG time series data and relating properties of the estimated state-transition dynamics to observables such as cognition and behavior. While microstate analysis has been widely employed to analyze EEG data, its use remains less prevalent in functional magnetic
-
Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail BMC Neurosci. (IF 2.4) Pub Date : 2024-03-04 Nasrin Niazi Nezhad, Abdolhossein Parnow, Kianoosh Khamoushian, Rasoul Eslami, Julien S Baker
The objectives of the present study was to investigate the effects of resistance training (RT) on serum levels of controlling blood-brain barrier (BBB) permeability indices and cognitive performance in MS women (MS-W). In this randomized control trail study (IRCT registration code: IRCT20120912010824N3, 07.09.2023), twenty-five MS-W were randomly divided into sedentary (MS) and resistance exercise
-
Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons BMC Neurosci. (IF 2.4) Pub Date : 2024-03-04 Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin, Hansjürgen Volkmer
Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used animal models or rather heterogeneous populations of iPSC-derived neurons, generated by undirected
-
Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats BMC Neurosci. (IF 2.4) Pub Date : 2024-03-04 Sarah A. Lechner, David G. S. Barnett, Stephen C. Gammie, Cynthia A. Kelm-Nelson
Parkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly understood; as such, there are no specific prognostic or diagnostic tests. A validated Pink1 genetic knockout rat was used to model early-onset and progressive PD. Male Pink1−/− rats exhibit progressive declines in ultrasonic vocalizations as well as hindlimb and forelimb
-
Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models BMC Neurosci. (IF 2.4) Pub Date : 2024-02-29 Katharina Ritter, Pawit Somnuke, Lingjiao Hu, Eva-Verena Griemert, Michael K.E. Schäfer
TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgical site infections or meningitis are frequent complications following TBI. Whether the use of preventive and/or symptomatic antibiotic therapy improves
-
A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΦGT mice BMC Neurosci. (IF 2.4) Pub Date : 2024-02-21 Anna Velica, Klas Kullander
A pseudotyped modified rabies virus lacking the rabies glycoprotein (G-protein), which is crucial for transsynaptic spread, can be used for monosynaptic retrograde tracing. By coupling the pseudotyped virus with transgene expression of the G-protein and the avian leukosis and sarcoma virus subgroup A receptor (TVA), which is necessary for cell entry of the virus, researchers can investigate specific
-
Multimodal evaluation of the effects of low-intensity ultrasound on cerebral blood flow after traumatic brain injury in mice BMC Neurosci. (IF 2.4) Pub Date : 2024-02-13 Huiling Yi, Shuo Wu, Xiaohan Wang, Lanxiang Liu, Wenzhu Wang, Yan Yu, Zihan Li, Yinglan Jin, Jian Liu, Tao Zheng, Dan Du
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide, and destruction of the cerebrovascular system is a major factor in the cascade of secondary injuries caused by TBI. Laser speckle imaging (LSCI)has high sensitivity in detecting cerebral blood flow. LSCI can visually show that transcranial focused ultrasound stimulation (tFUS) treatment stimulates angiogenesis
-
Modulation of long-term potentiation following microdoses of LSD captured by thalamo-cortical modelling in a randomised, controlled trial BMC Neurosci. (IF 2.4) Pub Date : 2024-02-05 Robin J. Murphy, Kate Godfrey, Alexander D. Shaw, Suresh Muthukumaraswamy, Rachael L. Sumner
Microdosing psychedelics is a phenomenon with claimed cognitive benefits that are relatively untested clinically. Pre-clinically, psychedelics have demonstrated enhancing effects on neuroplasticity, which cannot be measured directly in humans, but may be indexed by non-invasive electroencephalography (EEG) paradigms. This study used a visual long-term potentiation (LTP) EEG paradigm to test the effects
-
Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia BMC Neurosci. (IF 2.4) Pub Date : 2024-02-02 Weili Ma, Jack Oswald, Angela Rios Angulo, Qing Chen
Under pathological conditions, the immune-specialized brain microenvironment contains both resident microglia and bone marrow-derived myeloid cells recruited from peripheral circulation. Due to largely overlapping phenotypic similarities between these ontogenically distinct myeloid populations, studying their individual functions in central nervous system diseases has been challenging. Recently, transmembrane
-
Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α2A-adrenergic receptor BMC Neurosci. (IF 2.4) Pub Date : 2024-01-30 Chaoyong Tian, Yang Yang, Renfeng Wang, Yao Li, Fei Sun, Jun Chen, Dingjun Zha
The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIHL. In this study, we aimed at investigating the effects of a superior cervical ganglionectomy (SCGx) on NIHL in Sprague-Dawley rats. We explored the effects of unilateral and bilateral Superior
-
Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters BMC Neurosci. (IF 2.4) Pub Date : 2024-01-13 Abdul Gofir, Irawan Satriotomo, Yossy Catarina Budi Nur Syamsah, Mawaddah Ar Rochmah, Tommy Rachmat Setyawan, Adika Mianoki, Raymond Aris Nimrod Alvonsius Silalahi, Dhite Bayu Nugroho
Stroke is one of the neurological manifestations of COVID-19, leading to a significant risk of morbidity and mortality. Clinical manifestations and laboratory parameters were investigated to determine mortality predictors in this case. The case control study was conducted at Dr. Sardjito General Hospital,Yogyakarta, Indonesia, with data collected between July 2020 and August 2021. All recorded clinical
-
Ventral tegmental area dopaminergic circuits participates in stress-induced chronic postsurgical pain in male mice BMC Neurosci. (IF 2.4) Pub Date : 2024-01-09 Weizhen Liu, Wang Wang, Ziliang Wang, Ying Xing
Chronic postsurgical pain (CPP) markedly impairs patients’ quality of life. Research has shown that chronic stress may extend incisional nociception in male mice. Dopaminergic (DAergic) neurons in the ventral tegmental area (VTA) are integral to stress-related mental disorders (including major depressive disorder, anxiety disorders, and PTSD) and pain. However, the impact of chronic social defeat stress
-
Graph neural network and machine learning analysis of functional neuroimaging for understanding schizophrenia BMC Neurosci. (IF 2.4) Pub Date : 2024-01-02 Gayathri Sunil, Smruthi Gowtham, Anurita Bose, Samhitha Harish, Gowri Srinivasa
Graph representational learning can detect topological patterns by leveraging both the network structure as well as nodal features. The basis of our exploration involves the application of graph neural network architectures and machine learning to resting-state functional Magnetic Resonance Imaging (rs-fMRI) data for the purpose of detecting schizophrenia. Our study uses single-site data to avoid the
-
Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways BMC Neurosci. (IF 2.4) Pub Date : 2024-01-02 Sadie B. Baer, Adrianah D. Dorn, Danielle M. Osborne
Obesity rates in the U.S. continue to increase, with nearly 50% of the population being either obese or morbidly obese. Obesity, along with female sex, are leading risk factors for sporadic Alzheimer’s Disease (AD) necessitating the need to better understand how these variables impact cellular function independent of age or genetic mutations. Animal and clinical studies both indicate that autophagy-lysosomal
-
Regulatory effect of bacterial melanin on the isoforms of new superoxide-producing associates from rat tissues in rotenone-induced Parkinson’s disease BMC Neurosci. (IF 2.4) Pub Date : 2023-12-20 Margarita Danielyan, Kristina Nebogova, Ruzan Simonyan, Anichka Hovsepyan, Zubeida Avetisyan, Karen Simonyan, Gegham Simonyan, Vahagn Khachatryan, Kristine Karapetyan
According to recent research, selective neuronal vulnerability in Parkinson’s disease (PD) results from several phenotypic traits, including calcium-dependent, feed-forward control of mitochondrial respiration leading to elevated reactive oxygen species and cytosolic calcium concentration, an extensive axonal arbor, and a reactive neurotransmitter. Therefore, antioxidant therapy is a promising direction
-
Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer’s disease BMC Neurosci. (IF 2.4) Pub Date : 2023-12-18 Attila Kolonics, Zoltán Bori, Ferenc Torma, Dora Abraham, János Fehér, Zsolt Radak
It has been suggested that exercise training and postbiotic supplement could decelerate the progress of functional and biochemical deterioration in double transgenic mice overexpresses mutated forms of the genes for human amyloid precursor protein (APPsw) and presenilin 1 (m146L) (APP/PS1TG). Our earlier published data indicated that the mice performed better than controls on the Morris Maze Test parallel
-
Behavioral photosensitivity of multi-color-blind medaka: enhanced response under ultraviolet light in the absence of short-wavelength-sensitive opsins BMC Neurosci. (IF 2.4) Pub Date : 2023-12-14 Kiyono Mizoguchi, Mayu Sato, Rina Saito, Mayu Koshikuni, Mana Sakakibara, Ran Manabe, Yumi Harada, Tamaki Uchikawa, Satoshi Ansai, Yasuhiro Kamei, Kiyoshi Naruse, Shoji Fukamachi
The behavioral photosensitivity of animals could be quantified via the optomotor response (OMR), for example, and the luminous efficiency function (the range of visible light) should largely rely on the repertoire and expression of light-absorbing proteins in the retina, i.e., the opsins. In fact, the OMR under red light was suppressed in medaka lacking the red (long-wavelength sensitive [LWS]) opsin
-
Cognitive dysfunction in systemic lupus erythematosus is associated with disease activity and oxidative stress: a comparative study with rheumatoid arthritis for identifying biomarkers BMC Neurosci. (IF 2.4) Pub Date : 2023-12-13 Daniela Cabral de Sousa, Emmanuelle Silva Tavares Sobreira, Werbety Lucas Queiroz Feitosa, Ticiana Maria Pinto Moreira Aires, Leticia Pastuszka Paz Araújo, Andressa Laura Castro Silva, Caroline Brandão Joventino, Nathalia Maria Tomaz Silveira, Adriano José Maia Chaves-Filho, Danielle Silveira Macêdo, Pedro Braga-Neto
The prevalence and pathophysiological mechanisms of cognitive deficits (CD) Systemic Lupus Erythematosus (SLE) and Rheumatoid arthritis (RA) are very heterogeneous and poorly understood. We characterized CD in patients with SLE compared with RA patients and healthy controls. We compared the neuropsychological profile of SLE and RA with patients’ oxidative/inflammatory biomarkers for CD. We performed
-
Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders BMC Neurosci. (IF 2.4) Pub Date : 2023-12-12 Iryna S. Palamarchuk, George M. Slavich, Tracy Vaillancourt, Tarek K. Rajji
In this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that drive cognitive decline and behavioral change. First, we describe the general neurobiology of the stress response to define neurocognitive stress reactivity. Second, we review aspects of epigenetic regulation
-
Symptomatic intracranial hemorrhage mediates the association between eosinophils and 90-day outcomes after mechanical thrombectomy for acute ischemic stroke BMC Neurosci. (IF 2.4) Pub Date : 2023-12-08 Shuhong Yu, Xiaocui Wang, Hao Huang, Yi Luo, Zhiliang Guo
Decreased eosinophil level is associated with poor outcomes after mechanical thrombectomy in patients with acute ischemic stroke (AIS), but the underlying mechanism of this association is elusive. We aimed to assess the mediation effect of symptomatic intracranial hemorrhage (sICH) on the aforementioned association. A total of 328 consecutive AIS patients undergoing mechanical thrombectomy between
-
Effects of electroacupuncture on imaging and behavior in rats with ischemic stroke through miR-212-5p BMC Neurosci. (IF 2.4) Pub Date : 2023-12-06 Sisi Li, Xiangxin Xing, Xuyun Hua, Yuwen Zhang, Jiajia Wu, Chunlei Shan, Mouxiong Zheng, He Wang, Jianguang Xu
Ischemic stroke is a serious disease leading to significant disability in humans worldwide. Increasing evidence suggests that some microRNAs (miRNAs) participate in the pathophysiology of ischemic stroke. A key role for MiR-212 has been found in neuronal function and synaptic plasticity. Ischemic stroke can be effectively treated with electroacupuncture (EA); however, there is a lack of understanding
-
Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS BMC Neurosci. (IF 2.4) Pub Date : 2023-11-23 Oony-Iye Eepho, Al-Amin M. Bashir, Adesola A. Oniyide, Ayodeji Aturamu, Olutunmise V. Owolabi, Isaac O. Ajadi, Adedamola A. Fafure, Mary B. Ajadi, Stephanie E. Areloegbe, Kehinde S. Olaniyi
Polycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various neurodegenerative conditions. Hence, this study investigates the impact of butyrate in reversing hypothalamic-related disorder, possibly through γ aminobutyric acid (GABA) in a rat model of PCOS. Eight-week-old female Wistar rats were allotted into four groups
-
Monitoring the neural activity associated with praying in Sahaja Yoga meditation BMC Neurosci. (IF 2.4) Pub Date : 2023-11-13 Oscar Perez-Diaz, Alfonso Barrós-Loscertales, Uffe Schjoedt, José L. González-Mora, Katya Rubia, José Suero, Sergio Elías Hernández
Sahaja Yoga Meditation draws on many religious traditions and uses a variety of techniques including Christian prayer to reach a state known as thoughtless awareness, or mental silence. While there are many studies on the neural correlates of meditation, few studies have focused on the neural correlates of praying. Thus, the aim of our research was to study the neural activity associated with the prayer
-
Cycle-dependent sex differences in expression of membrane proteins involved in cerebrospinal fluid secretion at rat choroid plexus BMC Neurosci. (IF 2.4) Pub Date : 2023-11-09 Ida Marchen Egerod Israelsen, Christina Kamp-Jensen, Connar Stanley James Westgate, Bjarne Styrishave, Rigmor H. Jensen, Sajedeh Eftekhari
Female sex is a known risk factor of brain disorders with raised intracranial pressure (ICP) and sex hormones have been suggested to alter cerebrospinal fluid (CSF) dynamics, thus impairing ICP regulation in CSF disorders such as idiopathic intracranial hypertension (IIH). The choroid plexus (CP) is the tissue producing CSF and it has been hypothesized that altered hormonal composition could affect
-
Melatonin inhibits Japanese encephalitis virus replication and neurotoxicity via calcineurin-autophagy pathways BMC Neurosci. (IF 2.4) Pub Date : 2023-11-06 Ji-Hong Moon, Jeong-Min Hong, Jae-Won Seol, Byung-Yong Park, Seong Kug Eo, Sang-Youel Park
Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that has no specific treatment except for supportive medical care. JEV is a neurotropic virus that affects the nervous system and triggers inflammation in the brain. Melatonin is used as a sleep-inducing agent in neurophysiology and may serve as a protective agent against neurological and neurodegenerative diseases. Herein, we investigated
-
The molecular architecture of a complex social behavior: gregarious song BMC Neurosci. (IF 2.4) Pub Date : 2023-11-02 Tyler J. Stevenson
The medial preoptic area (mPOA) regulates the probability and intensity of singing behavior in birds. Polzin and colleagues examined the molecular changes in the mPOA that were associated with gregarious song in European starlings (Sturnus vulgaris). High-throughput transcriptome analyses identified glutamate and dopamine pathways were highly enriched with gregarious song.
-
Cytokine levels reflect tic symptoms more prominently during mild phases BMC Neurosci. (IF 2.4) Pub Date : 2023-10-31 SuHyuk Chi, Young Eun Mok, June Kang, Jeong-An Gim, Changsu Han, Moon-Soo Lee
Tic disorder is a neuropsychiatric condition that affects 3% of all children and can have a significant impact on their quality of life. Cytokines, interferons, interleukins, lymphokines, and tumor necrosis factors are involved in the neuroinflammatory circuitry of tic disorders. This study aimed to identify the cytokines involved in the pathogenesis of tic disorders. We enrolled 44 patients with tic
-
ANDA: an open-source tool for automated image analysis of in vitro neuronal cells BMC Neurosci. (IF 2.4) Pub Date : 2023-10-24 Hallvard Austin Wæhler, Nils-Anders Labba, Ragnhild Elisabeth Paulsen, Geir Kjetil Sandve, Ragnhild Eskeland
Imaging of in vitro neuronal differentiation and measurements of cell morphologies have led to novel insights into neuronal development. Live-cell imaging techniques and large datasets of images have increased the demand for automated pipelines for quantitative analysis of neuronal morphological metrics. ANDA is an analysis workflow that quantifies various aspects of neuronal morphology from high-throughput
-
Mindfulness interventions for craving reduction in substance use disorders and behavioral addictions: systematic review and meta-analysis of randomized controlled trials BMC Neurosci. (IF 2.4) Pub Date : 2023-10-18 Anastasia Demina, Benjamin Petit, Vincent Meille, Benoit Trojak
High-quality evidence is still required to affirm the efficacy of mindfulness-based interventions (MBIs) in craving reduction. MBIs may be particularly appropriate for this purpose given the neurobiological mechanisms of addiction with automatic behavior in response to the negative affect. In this systematic review and meta-analysis, we aimed to study the efficacy of MBIs in craving reduction and to
-
Metabolomics in severe traumatic brain injury: a scoping review BMC Neurosci. (IF 2.4) Pub Date : 2023-10-16 Riley Page Fedoruk, Chel Hee Lee, Mohammad Mehdi Banoei, Brent W. Winston
Diagnosis and prognostication of severe traumatic brain injury (sTBI) continue to be problematic despite years of research efforts. There are currently no clinically reliable biomarkers, though advances in protein biomarkers are being made. Utilizing Omics technology, particularly metabolomics, may provide new diagnostic biomarkers for sTBI. Several published studies have attempted to determine the
-
Comparison of efficacy of non-pharmacological intervention for post-stroke dysphagia: a systematic review and Bayesian network meta-analysis BMC Neurosci. (IF 2.4) Pub Date : 2023-10-16 Hao Zhu, Xinyuan Deng, Guorui Luan, Yu Zhang, Yichen Wu
Increasingly, non-pharmacological interventions are being identified and applied to post-stroke dysphagia. Nevertheless, there is insufficient evidence to assess which type of interventions are more effective. In this study, the randomized controlled trials of non-pharmacological interventions on post-stroke dysphagia were retrieved from the relevant databases. Including 96 studies and 12 non-drug
-
Effects of isoflurane and urethane anesthetics on glutamate neurotransmission in rat brain using in vivo amperometry BMC Neurosci. (IF 2.4) Pub Date : 2023-10-10 Joshua A. Beitchman, Gokul Krishna, Caitlin E. Bromberg, Theresa Currier Thomas
Aspects of glutamate neurotransmission implicated in normal and pathological conditions are predominantly evaluated using in vivo recording paradigms in rats anesthetized with isoflurane or urethane. Urethane and isoflurane anesthesia influence glutamate neurotransmission through different mechanisms; however, real-time outcome measures of potassium chloride (KCl)-evoked glutamate overflow and glutamate
-
Typical metabolic pattern of 18F-FDG PET in Anti-NMDAR encephalitis in the acute and subacute phases and its correlation with T2 FLAIR-MRI features BMC Neurosci. (IF 2.4) Pub Date : 2023-09-25 Leilei Yuan, Guangjuan Mao, Yudi Zhang, Yang Xu, Qian Chen, Baoci Shan, Tao Cui, Lin Ai
Early diagnosis of Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis with non-invasive imaging modalities benefiting is crucial to guarantee prompt treatments decision-making and good prognosis for patients. The present study aimed to explore the correlation of MRI features with brain metabolism characteristics of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) and to describe
-
Machine learning and EEG can classify passive viewing of discrete categories of visual stimuli but not the observation of pain BMC Neurosci. (IF 2.4) Pub Date : 2023-09-15 Tyler Mari, Jessica Henderson, S. Hasan Ali, Danielle Hewitt, Christopher Brown, Andrej Stancak, Nicholas Fallon
Previous studies have demonstrated the potential of machine learning (ML) in classifying physical pain from non-pain states using electroencephalographic (EEG) data. However, the application of ML to EEG data to categorise the observation of pain versus non-pain images of human facial expressions or scenes depicting pain being inflicted has not been explored. The present study aimed to address this
-
A spine segmentation method based on scene aware fusion network BMC Neurosci. (IF 2.4) Pub Date : 2023-09-14 Elzat Elham Yilizati-Yilihamu, Jintao Yang, Zimeng Yang, Feihao Rong, Shiqing Feng
Intervertebral disc herniation, degenerative lumbar spinal stenosis, and other lumbar spine diseases can occur across most age groups. MRI examination is the most commonly used detection method for lumbar spine lesions with its good soft tissue image resolution. However, the diagnosis accuracy is highly dependent on the experience of the diagnostician, leading to subjective errors caused by diagnosticians
-
Low-intensity transcranial ultrasound stimulation modulates neural activities in mice under propofol anaesthesia BMC Neurosci. (IF 2.4) Pub Date : 2023-08-30 Meiqi Liu, Yi Yuan, Xingran Wang, Teng Wang, Nannan Bian, Li Zhao, Guangying Cui, Wenchao Liu, Zhongfeng Ma, Xiaochun Yang, Shujuan Liang, Zhuo Liu
Previous studies have reported that transcranial focused ultrasound stimulation can significantly decrease the time to emergence from intraperitoneal ketamine-xylazine anaesthesia in rats. However, how transcranial focused ultrasound stimulation modulates neural activity in anaesthetized rats is unclear. In this study, to answer this question, we used low-intensity transcranial ultrasound stimulation
-
Enhancing research culture in academia: a spotlight on early career researchers BMC Neurosci. (IF 2.4) Pub Date : 2023-08-29 Kim I Chisholm, Mattéa J. Finelli
This editorial highlights common challenges faced by early career researchers (ECRs) who play a crucial role in our research community. We propose that enhancing the experiences of ECRs will yield benefits to the entire scientific community and we give practical suggestions on how such improvements may be achieved.
-
Correction: Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β1–42 rat model BMC Neurosci. (IF 2.4) Pub Date : 2023-08-28 Mara A. Guzmán‑Ruiz, Amor Herrera‑González, Adriana Jiménez, Alan Candelas‑Juárez, Crystal Quiroga‑Lozano, Claudia Castillo‑Díaz, Erika Orta‑Salazar, Diana Organista‑Juárez, Sofía Díaz‑Cintra, Rosalinda Guevara‑Guzmán
Correction: BMC Neurosci (2021) 22:14 https://doi.org/10.1186/s12868-021-00620-9 Following publication of the original article [1], the authors identified errors in Fig. 2b and e and Additional file 1: Fig. S2. In Fig. 2b we have now changed the APN-βA representative figure for IBA1 micrographs. In the original figure the same APN-βA section for Fig. 2b, e since it was the best preserved section.
-
Correction: Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity BMC Neurosci. (IF 2.4) Pub Date : 2023-08-24 Yulan Liu, Yang Meng, Chenliang Zhou, Juanjuan Yan, Cuiping Guo, Weiguo Dong
Correction: BMC Neurosci 24, 14 (2023) https://doi.org/10.1186/s12868-023-00782-8 Following the publication of the original article [1], the editors reported that there were some inconsistencies in the use of English. The authors provided an edited version of the manuscript. The original article [1] has been updated. The content was not affected by this correction. Liu Y, Meng Y, Zhou C, et al. Activation
-
Related neural networks underlie suppression of emotion, memory, motor processes as identified by data-driven analysis BMC Neurosci. (IF 2.4) Pub Date : 2023-08-24 Karisa J. Hunt, Lindsay K. Knight, Brendan E. Depue
Goal-directed behavior benefits from self-regulation of cognitive and affective processes, such as emotional reactivity, memory retrieval, and prepotent motor response. Dysfunction in self-regulation is a common characteristic of many psychiatric disorders, such as PTSD and ADHD. This study sought to determine whether common intrinsic connectivity networks (ICNs; e.g. default mode network) are involved
-
Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein BMC Neurosci. (IF 2.4) Pub Date : 2023-08-23 Ashoka C. Bandla, Aditya S. Sheth, Sara M. Zarate, Suraj Uskamalla, Elizabeth C. Hager, Victor A. Villarreal, Maribel González-García, Rafael P. Ballestero
Studies of the molecular mechanisms of nerve regeneration have led to the discovery of several proteins that are induced during successful nerve regeneration. RICH proteins were identified as proteins induced during the regeneration of the optic nerve of teleost fish. These proteins are 2’,3’-cyclic nucleotide, 3’-phosphodiesterases that can bind to cellular membranes through a carboxy-terminal membrane
-
Retraction Note: Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line BMC Neurosci. (IF 2.4) Pub Date : 2023-08-14 Samin Hong, Jong Eun Lee, Chan Yun Kim, Gong Je Seong
BMC Neuroscience volume (2007) 81 The Editor has retracted this article. Overlap has been detected within the figures of this article, specifically: In Fig. 5A there appears to be overlap between the blots for the 3h pJNK and the 6h pJNK In Fig. 6A the NF-κB (Nucleus) 30min blot appears to overlap with the pNF-κB (cytoplasm) 30 min blot in Fig. 6B In Fig. 6A the pNF-κB (Nucleus) 1h blot appears to
-
Distinct patterns of gene expression in the medial preoptic area are related to gregarious singing behavior in European starlings (Sturnus vulgaris) BMC Neurosci. (IF 2.4) Pub Date : 2023-08-03 Brandon J. Polzin, Sharon A. Stevenson, Stephen C. Gammie, Lauren V. Riters
Song performed in flocks by European starlings (Sturnus vulgaris), referred to here as gregarious song, is a non-sexual, social behavior performed by adult birds. Gregarious song is thought to be an intrinsically reinforced behavior facilitated by a low-stress, positive affective state that increases social cohesion within a flock. The medial preoptic area (mPOA) is a region known to have a role in
-
Transcriptome analysis reveals the neuroprotective effect of Dlg4 against fastigial nucleus stimulation-induced ischemia/reperfusion injury in rats BMC Neurosci. (IF 2.4) Pub Date : 2023-07-31 Jinggui Gao, Xiaomin Pang, Lei Zhang, Shenghua Li, Zhenxiu Qin, Xiaoyun Xie, Jingli Liu
Previous studies have demonstrated that electrical stimulation of the cerebellar fastigial nucleus (FNS) can considerably decrease infarction volume and improve neurofunction restoration following cerebral ischemia. Nevertheless, the molecular mechanism of the neuroprotective effect of FNS is still vague. In this study, we developed a rat model of ischemia/reperfusion that included 1 h FNS followed
-
Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice BMC Neurosci. (IF 2.4) Pub Date : 2023-07-31 Dong Ho Kang, Sunjoo Ahn, Jung Woo Chae, Jin Sook Song
Several phosphodiesterase 4 (PDE4) inhibitors have emerged as potential therapeutics for central nervous system (CNS) diseases. This study investigated the pharmacological effects of two selective PDE4 inhibitors, roflumilast and zatolmilast, against lipopolysaccharide-induced neuroinflammation. In BV-2 cells, the PDE4 inhibitor roflumilast reduced the production of nitric oxide and tumor necrosis
-
Mini review: Current status and perspective of S100B protein as a biomarker in daily clinical practice for diagnosis and prognosticating of clinical outcome in patients with neurological diseases with focus on acute brain injury BMC Neurosci. (IF 2.4) Pub Date : 2023-07-20 Tammam Abboud, Veit Rohde, Dorothee Mielke
Prognosticating the clinical outcome of neurological diseases is essential to guide treatment and facilitate decision-making. It usually depends on clinical and radiological findings. Biomarkers have been suggested to support this process, as they are deemed objective measures and can express the extent of tissue damage or reflect the degree of inflammation. Some of them are specific, and some are
-
Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner BMC Neurosci. (IF 2.4) Pub Date : 2023-07-20 Yuanyuan Bai, Wen Mi, Xiaoyin Meng, Beibei Dong, Yi Jiang, Yuechun Lu, Yonghao Yu
Hydrogen (H2) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. We examined whether it is related to PPARα and its regulatory targets, ABC efflux transporters. After injection with DMSO/GW6471 (a PPARα inhibitor), the mice subjected to sham/caecal ligation and puncture (CLP) surgery were treated with H2 for 60 min postoperation
-
Correction to: Similar cortical morphometry trajectories from 5 to 9 years in children with perinatal HIV who started treatment before age 2 years and uninfected controls BMC Neurosci. (IF 2.4) Pub Date : 2023-07-12 Emmanuel C. Nwosu, Martha J. Holmes, Mark F. Cotton, Els Dobbels, Francesca Little, Barbara Laughton, Andre van der Kouwe, Frances Robertson, Ernesta M. Meintjes
Correction to: BMC Neuroscience (2023) 24:15 https://doi.org/10.1186/s12868-023-00783-7 Following publication of the original article [1], the authors identified errors in Table 1 and 2. The correct Tables are given hereafter. Table 1 Biographical data for all participants (N = 141; 75 PHIV, 66 HIV-)Full size table Table 2 Clinical data for all children with PHIV (N = 75)Full size table The original
-
Psychedelics and neural plasticity BMC Neurosci. (IF 2.4) Pub Date : 2023-06-30 Rachael Sumner, Kacper Lukasiewicz
When it comes to studying neural plasticity and psychedelics, the numerous and diverse neuroscientific fields converging on the topic provide unique insight into a complex picture. This editorial will describe the major ways in which the known effects of psychedelics on plasticity are being studied. We lay out strengths of different techniques and the major gaps and room for future research, particularly
-
A novel approach to CSF pressure measurement via lumbar puncture that shortens the measurement time with a high level of accuracy BMC Neurosci. (IF 2.4) Pub Date : 2023-06-18 Duygu Yücel, Yekta Ülgen
Intracranial pressure (ICP) is an important parameter in clinical management and diagnosis of several neurological diseases which is indirectly measured via lumbar puncture (LP). In routine measurements of cerebrospinal fluid pressure (PCSF) from lumbar region, a spinal needle and a spinal manometer are used. PCSF measurement via LP with the use of a spinal manometer may not yield correct PCSF results
-
iAstrocytes do not restrain T cell proliferation in vitro BMC Neurosci. (IF 2.4) Pub Date : 2023-06-07 Emanuela Colombo, Anthea De Angelis, Claudia Bassani, Francesca Ruffini, Linda Ottoboni, Livia Garzetti, Annamaria Finardi, Gianvito Martino, Roberto Furlan, Cinthia Farina
The cross-talk between T cells and astrocytes occurring under physiological and, even more, neuroinflammatory conditions may profoundly impact the generation of adaptive immune responses in the nervous tissue. In this study, we used a standardized in vitro co-culture assay to investigate the immunomodulatory properties of astrocytes differing for age, sex, and species. Mouse neonatal astrocytes enhanced
-
The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain BMC Neurosci. (IF 2.4) Pub Date : 2023-06-01 Mikaela M. Ceder, Hannah M. Weman, Ebba Johansson, Katharina Henriksson, Kajsa A. Magnusson, Erika Roman, Malin C. Lagerström
The glycinergic system plays an important inhibitory role in the mouse central nervous system, where glycine controls the excitability of spinal itch- and pain-mediating neurons. Impairments of the glycine receptors can cause motor and sensory deficits. Glycine exerts inhibition through interaction with ligand-gated ion channels composed of alpha and beta subunits. We have investigated the mRNA expression
-
Correction: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats BMC Neurosci. (IF 2.4) Pub Date : 2023-05-22 Junjie Zhou, Chao Zhang, Xu Fang, Naixin Zhang, Xiaoxi Zhang, Zhaoqiong Zhu
Correction: BMC Neurosci 24, 9 (2023) https://doi.org/10.1186/s12868-023-00777-5 Following publication of the original article [1], the authors reported that the order of affiliations was inverted. The corrected affiliations are the following: 1Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan District, 563,000, Zunyi, Guizhou, China. 2Zunyi Medical University, 6 Xuefu West
-
High frequencies (HF) repetitive transcranial magnetic stimulation (rTMS) increase motor coordination performances in volleyball players BMC Neurosci. (IF 2.4) Pub Date : 2023-05-09 Fiorenzo Moscatelli, Giusi Antonia Toto, Anna Valenzano, Giuseppe Cibelli, Vincenzo Monda, Pierpaolo Limone, Nicola Mancini, Antonietta Messina, Gabriella Marsala, Giovanni Messina, Rita Polito
It is widely demonstrated that high frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has facilitative effects and is therefore capable to inducing changes in motor responses. One of the most investigated areas is the dorsolateral prefrontal cortex (DLPFC) as it plays a special executive attention role in actively preserving access to stimulus representations and objectives in environments
-
Characterization of the planarian surface electroencephalogram BMC Neurosci. (IF 2.4) Pub Date : 2023-05-03 Jannes Freiberg, Lukas Lang, Christian Kaernbach, Julian Keil
Despite large morphological differences between the nervous systems of lower animals and humans, striking functional similarities have been reported. However, little is known about how these functional similarities translate to cognitive similarities. As a first step towards studying the cognitive abilities of simple nervous systems, we here characterize the ongoing electrophysiological activity of
-
Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway BMC Neurosci. (IF 2.4) Pub Date : 2023-05-01 Jiyun Choi, Jinsu Hwang, Mahesh Ramalingam, Han-Seong Jeong, Sujeong Jang
Histone deacetylase (HDAC) inhibitors affect cell homeostasis, gene expression, and cell cycle progression and promote cell terminal differentiation or apoptosis. However, the effect of HDAC inhibition on SH-SY5Y cells, which are neuroblastoma cells capable of differentiating into neurons under specific conditions, such as in the presence of retinoic acid (RA), is unknown. In this study, we hypothesized