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Predicting functional outcome in acute ischemic stroke patients after endovascular treatment by machine learning. Trans. Neurosci. (IF 2.1) Pub Date : 2023-11-27 Zhenxing Liu,Renwei Zhang,Keni Ouyang,Botong Hou,Qi Cai,Yu Xie,Yumin Liu
Background Endovascular therapy (EVT) was the standard treatment for acute ischemic stroke with large vessel occlusion. Prognosis after EVT is always a major concern. Here, we aimed to explore a predictive model for patients after EVT. Method A total of 156 patients were retrospectively enrolled. The primary outcome was functional dependence (defined as a 90-day modified Rankin Scale score ≤ 2). Least
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PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice. Trans. Neurosci. (IF 2.1) Pub Date : 2023-11-15 Tiantian Liu,Xinlu Chen,Ziqi Wei,Xue Han,Yujia Liu,Zhengliang Ma,Tianjiao Xia,Xiaoping Gu
Background Due to high rates of incidence and disability, postoperative cognitive dysfunction (POCD) currently receives a lot of clinical attention. Disturbance of fatty acid oxidation is a potential pathophysiological manifestation underlying POCD. Peroxisome proliferator-activated receptor α (PPARα) is a significant transcription factor of fatty acid oxidation that facilitates the transfer of fatty
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Evaluation of the improvement of walking ability in patients with spinal cord injury using lower limb rehabilitation robots based on data science. Trans. Neurosci. (IF 2.1) Pub Date : 2023-11-11 Hui Zhao,Jingyi Yang,Jie Yang,Hongying Jiang,Yecai Qin,Qian Lei
Spinal cord injury (SCI) is a serious disabling injury, and the main factors causing SCI in patients include car accidents, falls from heights, as well as heavy blows and falls. These factors can all cause spinal cord compression or even complete rupture. After SCI, problems with the movement, balance, and walking ability of the lower limbs are most common, and SCI can cause abnormalities in patient's
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Long-term sevoflurane exposure relieves stress-enhanced fear learning and anxiety in PTSD mice. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-28 Ying Du,Minhui Xu,Yan Su,Yujia Liu,Yiming Zhou,Xiaoping Gu,Tianjiao Xia
Objectives Post-traumatic stress disorder (PTSD) is characterized by recurrent episodes of severe anxiety after exposure to traumatic events. It is believed that these episodes are triggered at least in part by environmental stimuli associated with the precipitating trauma through classical conditioning, termed conditioned fear. However, traditional methods of conditioned fear memory extinction are
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Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-25 Li Bao,Xiao-Mei Lan,Guo-Qing Zhang,Xi Bao,Bo Li,Dan-Na Ma,Hong-Yan Luo,Shi-Lu Cao,Shun-Yao Liu,E Jing,Jian-Zhong Zhang,Ya-Li Zheng
Objectives Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells. However, the function of Cdk5 on the transformation of immortalized Cos-7 cells into neuronal-like cells is not clear. Methods Cdk5 kinase activity was measured by [γ-32P] ATP and p81 phosphocellulose pads based method
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7-Day National Institutes of Health Stroke Scale as a surrogate marker predicting ischemic stroke patients' outcome following endovascular therapy. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-19 Yuzheng Lai,Eric Jou,Mohammad Mofatteh,Thanh N Nguyen,Jamie Sin Ying Ho,Francesco Diana,Adam A Dmytriw,Jianfeng He,Wenshan Yan,Yiying Chen,Zile Yan,Hao Sun,Leonard L Yeo,Yimin Chen,Sijie Zhou
Background Early neurological deterioration after endovascular thrombectomy (EVT) is associated with poor prognosis. National Institutes of Health Stroke Scale (NIHSS) score measured at 24 h after EVT may be a better outcome predictor than other methods that focus on changes in NIHSS. Nevertheless, clinical fluctuations in ischemic stroke patients during the immediate phase after symptoms onset are
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Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-18 Abdurrahman Aycan,Abdurrahim Tas,Asli Cilingir Yeltekin,Sama Amer Abbas El-Tekreti,Ayse Arslan,Mustafa Arslan,Nur Aycan
Background Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological
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Excessive MALAT1 promotes the immunologic process of neuromyelitis optica spectrum disorder by upregulating BAFF expression. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-17 Jing Chen,Lijie Zhang,Jingyu Lin,Zeng Wang,Aiyu Lin
Increased B cell activating factor (BAFF) expression in patients with neuromyelitis optica spectrum disorder (NMOSD) is associated with B cell overstimulation, but the underlying mechanism remains unclear. This study aimed to reveal the emerging mechanisms that regulate BAFF expression in the inflammatory process of NMOSD. The results showed that the expression of miR-30b-5p was significantly decreased
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CST3 alleviates bilirubin-induced neurocytes' damage by promoting autophagy. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-16 Zhenkun Li,Yating Du
High concentrations of unconjugated bilirubin (UCB) have toxic effects. The aim of our study was to find a way to elevate UCB tolerance or inhibit its toxicity in neurocytes. It has been reported that cystatin C (CST3) concentrations have a significant positive correlation with total bilirubin (TB) levels and a negative correlation with albumin levels. In addition, CST3 can directly bind UCB, decrease
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Human prion diseases and the prion protein - what is the current state of knowledge? Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-16 Reinhold Nafe,Christophe T Arendt,Elke Hattingen
Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical
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Effects of edaravone dexborneol on neurological function and serum inflammatory factor levels in patients with acute anterior circulation large vessel occlusion stroke. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-12 Xiaohong Hu,Zhenhong Qian,Jianhui Chen,Mingsheng Chen,Wenying Zhong,Chaoxiong Shen,Zhizhou Hu,Rongtong Li
The goal of this study is to evaluate and analyze the effects of edaravone (EDV) dexborneol on neurological function and serum inflammatory factor levels among patients with acute anterior circulation big artery blockage stroke. A total of 142 patients with acute anterior circulation large vessel occlusion (LVO) were randomly allocated to the study group (69 patients) or the control group (73 patients)
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Electroacupuncture inhibits the expression of HMGB1/RAGE and alleviates injury to the primary motor cortex in rats with cerebral ischemia. Trans. Neurosci. (IF 2.1) Pub Date : 2023-10-09 Zeyin Nie,Huachun Miao,Chenyu Li,Feng Wu
Background The high-mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) signaling pathway holds promise as a potential therapeutic target for ischemic brain injury. The effects of FPS-ZM1 and electroacupuncture (EA) on activation of the HMGB1/RAGE signaling pathway after cerebral ischemia remain uncertain. Methods Middle cerebral artery occlusion (MCAO) model was established
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Effects of γ-oryzanol on motor function in a spinal cord injury model. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-20 ZhiYi Fan,WanDa Zhan,Jun Cai
Objective Spinal cord injury (SCI) is caused by disease or trauma and results in a partial or complete loss of motor or sensory function below the injury level. Most patients with SCI are young, and long-term disability imposes both psychological and financial burdens. Rice is the most abundant source of γ-oryzanol, which exhibits both antioxidant and anti-inflammatory properties. γ-Oryzanol has been
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Association between RS3763040 polymorphism of the AQP4 and idiopathic intracranial hypertension in a Spanish Caucasian population. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-11 Juan José Tellería-Orriols,Samsara López-Hernández,Inmaculada Vidriales-Vicente,Carlos Alberto Rodríguez-Arias
Background Idiopathic intracranial hypertension (IIH) is a condition of increased intracranial pressure of unknown aetiology. Principal symptoms are headache, visual disturbances, and obesity, together with elevated intracranial pressure. Unspecified MRI, despite normal ventricle size, suggests alterations in the water flux cellular mediated by the brain water channel aquaporin-4 (AQP4). The association
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Brain functional connectivity and network characteristics changes after vagus nerve stimulation in patients with refractory epilepsy. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-07 Yongqiang Ding,Kunlin Guo,Xinjun Wang,Mingming Chen,Xinxiao Li,Yuehui Wu
Objective This study aims to investigate the impact of vagus nerve stimulation (VNS) on the connectivity and small-world metrics of brain functional networks during seizure periods. Methods Ten refractory epilepsy patients underwent video encephalographic monitoring before and after VNS treatment. The 2-min electroencephalogram segment containing the ictal was selected for each participant, resulting
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PD98059 protects SH-SY5Y cells against oxidative stress in oxygen-glucose deprivation/reperfusion. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-06 Xiang-Zhen Zhuge,Wan-Xiang Hu,Yu-Mei Liu,Chang-Yue Jiang,Xiao-Hua Zhang,Meng-Hua Chen,Lu Xie
Mitochondria play a key role in the cerebral ischemia-reperfusion injury. Although the extracellular signal-regulated kinase 1/2 inhibitor PD98059 (PD) is a selective and reversible flavonoid that can protect the mitochondria in a rat model of cardiac arrest/cardiopulmonary resuscitation, its role requires further confirmation. In this study, we investigated whether PD could maintain mitochondrial
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An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-06 Jing-Kun Zhao,Si-Jia Hou,Ji-Wei Zhao,Hong-Li Yu,Shu-Rong Duan
Background Baicalin has been shown to promote spatial learning and neural regeneration, which might increase the differentiation of neural stem cells in Alzheimer's disease (AD) rat models. We aimed to study the role of baicalin on neuronal pentraxin-1 (NPTX-1), neuronal pentraxin-2 (NPTX-2), and C-reactive protein (CRP) in AD model rats. Methods The 30 male Sprague Dawley rats were divided into three
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TPVB and general anesthesia affects postoperative functional recovery in elderly patients with thoracoscopic pulmonary resections based on ERAS pathway. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-06 Na An,Wenzhe Dong,Guangdong Pang,Yiwei Zhang,Chunling Liu
Objective Thoracic surgery is easy to cause various perioperative complications, especially in elderly patients, due to their physical weakness and physiological function degeneration. Postoperative cognitive dysfunction is a common complication in elderly patients undergoing thoracic surgery. This study focuses on exploring the effects of thoracic paravertebral block (TPVB) combined with general anesthesia
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Effects of enriched environment on the expression of β-amyloid and transport-related proteins LRP1 and RAGE in chronic sleep-deprived mice. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-01 Ren Yuan,Zhang Yisen,Wang Xiu,Tang Wei,Wang Wei
Sleep plays an important role in the learning process and memory consolidation, and sleep deprivation (SD) leads to inadequate memory consolidation and plays an important role in brain development and plasticity. SD increases β-amyloid levels while impairing cognitive function. We explored the effect of enriched environment (EE) on β-amyloid and transporter protein LRP1 and receptor for advanced glycosylation
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Deletion as novel variants in VPS13B gene in Cohen syndrome: Case series. Trans. Neurosci. (IF 2.1) Pub Date : 2023-09-01 Li Kang,Yixuan Ma,Peng Zhao
Background Cohen syndrome (OMIM No. # 216550) is a rare autosomal recessive disorder caused by homozygous mutation in the vacuolar protein sorting 13 homolog B (VPS13B) gene on chromosome 8q22.2. Clinical manifestations include hypermobile joints, microcephaly, intellectual disabilities, craniofacial and limb anomalies, and neutropenia. To date, more than 200 mutations of VPS13B have been reported
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The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway. Trans. Neurosci. (IF 2.1) Pub Date : 2023-08-23 Guiying Kuang,Zhigang Shu,Chunli Zhu,Hongbing Li,Cheng Zhang
Objective The objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor tyrosine kinase with immunoglobulin-like and EGF-like domains (Ang receptor) 2 (Tie-2) signaling pathways, which may underlie the cognitive improvement
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Relationship between serum HIF-1α and VEGF levels and prognosis in patients with acute cerebral infarction combined with cerebral-cardiac syndrome. Trans. Neurosci. (IF 2.1) Pub Date : 2023-08-18 Qing Chang,Hongna Liu,Ermiao Zhang,Qian Xue,Aixia Song
Objective This research was conducted to discuss the recent prognosis of patients with acute cerebral infarction (ACI) combined with cerebral-cardiac syndrome (CCS). Method Eighty-seven patients with ACI were selected, which were divided into the ACI group (52 patients) and the CCS group (35 patients) according to whether the CCS was combined, and another 30 health controls were selected as the control
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CircYIPF6 regulates glioma cell proliferation, apoptosis, and glycolysis through targeting miR-760 to modulate PTBP1 expression. Trans. Neurosci. (IF 2.1) Pub Date : 2023-08-11 Dan Lei,Wenyong Xiao,Bo Zhang
Background Recent studies have highlighted that circular RNAs regulate cancer-related genes' expression by functioning as microRNA sponges in cancers. Herein, we investigated the function and molecular mechanism of circYIPF6 in glioma. Methods 5-Ethynyl-2'-deoxyuridine assay, colony formation, and flow cytometry were performed to assess the proliferation and apoptosis of glioma cells. The levels of
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Knockdown of circEXOC6 inhibits cell progression and glycolysis by sponging miR-433-3p and mediating FZD6 in glioma. Trans. Neurosci. (IF 2.1) Pub Date : 2023-08-02 Yu Deng,Liu Xu,Yuqiang Li
Background The effect of circular RNA in many human cancers is widely studied. Nevertheless, their specific biological functions and mechanisms in glioma remain unclear. Methods CircEXOC6, miR-433-3p, and frizzled class receptor 6 (FZD6) mRNA expression levels were measured by quantitative reverse transcription polymerase chain reaction assay. Cell proliferation, migration, invasion, apoptosis, and
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Hematoma evacuation based on active strategies versus conservative treatment in the management of moderate basal ganglia hemorrhage: A retrospective study. Trans. Neurosci. (IF 2.1) Pub Date : 2023-07-29 Weihua Zhang,Jian Zhang,Gaoming Huang,Kaichuang Yang
Objective The internal capsule of the basal ganglia is vulnerable to direct pressure from the hematoma and to secondary damage from toxic products of hemorrhage. Our study evaluated the risk and benefits of active strategies including ultra-early surgery and hematoma evacuation through a transsylvian-transinsular approach for moderate basal ganglia hemorrhage. Methods We retrospectively collected patients
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EHMT2 affects microglia polarization and aggravates neuronal damage and inflammatory response via regulating HMOX1. Trans. Neurosci. (IF 2.1) Pub Date : 2023-07-27 Huaitao Yang,Zhifang Chen,Wenhong Gao
Objective This research was designed to ascertain the function of euchromatic histone lysine methyltransferase 2 (EHMT2) in ischemic stroke-induced neuronal damage and inflammatory response and its regulatory mechanism. Methods Mouse microglia (BV-2 cells) were induced by oxygen glucose deprivation/reoxygenation (OGD/R) to establish a cellular model, and then co-cultured with HT22 hippocampal neurons
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Esmolol inhibits cognitive impairment and neuronal inflammation in mice with sepsis-induced brain injury. Trans. Neurosci. (IF 2.1) Pub Date : 2023-07-25 Yanpeng Li,Junli Ma,Jianjun Diao,Wei Chen,Zhihua Wang
Sepsis is a potentially fatal organ failure resulting from a dysregulated host response to infection. It can be a substantial financial burden on families and society due to the high cost of medical care. The study aims to investigate the protective roles of Esmolol in mice with sepsis-induced brain injuries against cognitive dysfunction and neuronal inflammation. Male C57BL/6J mice were intraperitoneally
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HOTAIRM1 knockdown reduces MPP+-induced oxidative stress injury of SH-SY5Y cells by activating the Nrf2/HO-1 pathway. Trans. Neurosci. (IF 2.1) Pub Date : 2023-07-25 Hui-Yu Dai,Ming-Xiu Chang,Ling Sun
Objective Parkinson's disease (PD) is the second most common neurodegenerative disease with complex pathogenesis. Although HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is upregulated in PD, its exact role in HOTAIRM1 is seldom reported. The purpose of this study is to research the effect of HOTAIRM1 on 1-methyl-4-phenylpyridonium (MPP+)-induced cytotoxicity and oxidative stress in SH-SY5Y
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Incomplete circle of Willis as a risk factor for intraoperative ischemic events during carotid endarterectomies performed under regional anesthesia - A prospective case-series. Trans. Neurosci. (IF 2.1) Pub Date : 2023-07-10 Zoltán Gyöngyösi,Ivett Belán,Edit Nagy,Zsófia Fülesdi,Orsolya Farkas,Tamás Végh,Arjan Willem Hoksbergen,Béla Fülesdi
Background The role of the willisian collaterals during carotid endarterectomies (CEAs) is a debated issue. The aim of the present work was to test whether an incomplete or non-functional circle of Willis (CoW) is a risk factor for ischemic events during CEA. Patients and methods CEAs were performed under local anesthesia. Patients were considered symptomatic (SY) if neurological signs appeared after
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Comprehensive behavioral study of C57BL/6.KOR-ApoEshl mice. Trans. Neurosci. (IF 2.1) Pub Date : 2023-06-30 Hiroshi Ueno,Yu Takahashi,Shinji Murakami,Kenta Wani,Tetsuji Miyazaki,Yosuke Matsumoto,Motoi Okamoto,Takeshi Ishihara
Background Apolipoprotein E (ApoE) is associated with Alzheimer's disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoeshl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities
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The clinical characteristics of acute cerebral infarction patients with thalassemia in a tropic area in China. Trans. Neurosci. (IF 2.1) Pub Date : 2023-06-20 Liyuan Liu,Xinyu Ben,Chang Li,Jiaqi Liu,Lin Ma,Xiaoping Liao,Qin Zou,Qifu Li
This study aimed to explore the clinical characteristics of acute cerebral infarction (ACI) patients with thalassemia through the analysis of clinical data. Adult patients with ACI who were admitted to the First Affiliated Hospital of Hainan Medical College, the Second Affiliated Hospital of Hainan Medical College, Hainan Provincial People's Hospital, and the Department of Neurology of Haikou People's
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Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway. Trans. Neurosci. (IF 2.1) Pub Date : 2023-06-09 Qian Sun,Xiangjian Zhang,Jingyi Fan,Lan Zhang,Hui Ji,Jing Xue,Cong Zhang,Rong Chen,Jing Zhao,Junmin Chen,Xiaoxia Liu,Degang Song
Context Accumulated evidence indicates that geniposide exhibits neuroprotective effects in ischemic stroke. However, the potential targets of geniposide remain unclear. Objective We explore the potential targets of geniposide in ischemic stroke. Materials and methods Adult male C57BL/6 mice were subjected to the middle cerebral artery occlusion (MCAO) model. Mice were randomly divided into five groups:
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Arterial spin labeling for moyamoya angiopathy: A preoperative and postoperative evaluation method. Trans. Neurosci. (IF 2.1) Pub Date : 2023-06-07 Sun Yuxue,Wang Yan,Xue Bingqian,Liang Hao,Li Chaoyue
Objectives Studies have shown that arterial spin labeling (ASL) effectively replaces traditional MRI perfusion imaging for detecting cerebral blood flow (CBF) in patients with Moyamoya angiopathy (MMA). However, there are few reports on the relationship between neovascularization and cerebral perfusion in patients with MMA. The aim of this study is to investigate the effects of neovascularization on
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Thyroid hormone levels paradox in acute ischemic stroke. Trans. Neurosci. (IF 2.1) Pub Date : 2023-06-07 Chunhui Xie,Yi Jiang,Xiaozhu Shen,Mengqian Liu,Yiwen Xu,Wen Zhong,Zhonglin Ge,Mingyue Qian,Nan Dong,Chen Gong,Guanghui Zhang
Objective Accumulating evidence has suggested that thyroid hormone levels affect the prognosis of acute ischemic stroke (AIS), but the results have been inconsistent. Methods Basic data, neural scale scores, thyroid hormone levels, and other laboratory examination data of AIS patients were collected. The patients were divided into excellent and poor prognosis group at discharge and 90 days after discharge
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miR-101-3p improves neuronal morphology and attenuates neuronal apoptosis in ischemic stroke in young mice by downregulating HDAC9. Trans. Neurosci. (IF 2.1) Pub Date : 2023-05-26 Mengru Zhang,Jianjun Wang,Jinfang Li,Fanxin Kong,Songjun Lin
Objective MiRNAs play a key role in ischemic stroke (IS). Although miR-101-3p can participate in multiple disease processes, its role and mechanism in IS are not clear. The aim of the present study was to observe the effect of miR-101-3p activation on IS in young mice and the role of HDAC9 in this effect. Methods The young mice were first subjected to transient middle cerebral artery occlusion (tMCAO)
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A custom-made weight-drop impactor to produce consistent spinal cord injury outcomes in a rat model. Trans. Neurosci. (IF 2.1) Pub Date : 2023-05-26 Ali Jarragh,Ali Shuaib,Ghanim Al-Khaledi,Fatima Alotaibi,Sulaiman Al-Sabah,Willias Masocha
Objective The main objective of this study is to design a custom-made weight-drop impactor device to produce a consistent spinal cord contusion model in rats in order to examine the efficacy of potential therapies for post-traumatic spinal cord injuries (SCIs). Methods Adult female Sprague-Dawley rats (n = 24, 11 weeks old) were randomly divided equally into two groups: sham and injured. The consistent
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Inactivation of CACNA1H induces cell apoptosis by initiating endoplasmic reticulum stress in glioma. Trans. Neurosci. (IF 2.1) Pub Date : 2023-05-26 Sheng Liu,Ying Ba,Chenglong Li,Guangming Xu
Background Ca2+ channels are abnormally expressed in various tumor cells and are involved in the progression of human glioma. Here, we explored the role of a calcium channel, voltage-dependent, T-type, alpha 1H subunit (CACNA1H), which encodes T-type Ca2+ channel Cav3.2 in glioma cells. Methods Cell viability and apoptosis were detected using cell-counting kit-8 and flow cytometry, respectively. The
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Does the patellar tendon reflex affect the postural stability in stroke patients with blocked vision? Trans. Neurosci. (IF 2.1) Pub Date : 2023-04-17 Ziyou Zhou,Zhen Hu,Wei Bao,Ying Yang,Kai Chen
Background Stroke patients often show postural instability. The patellar tendon reflex is a basic physical examination for stroke patients. This study aimed to explore the correlation between patellar tendon reflex grade and postural stability among stroke patients. Methods A total of 37 elderly stroke patients, each with the same quadriceps muscle strength but different patellar tendon reflex levels
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TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways. Trans. Neurosci. (IF 2.1) Pub Date : 2023-04-11 Rui Jian,Xin He
Objective Anesthetic exposure causes learning and memory impairment, the mechanisms of which remain unknown. It has been reported that tumor necrosis factor-α-inducer protein 8-like 2 (TIPE2) is a newly discovered immune negative regulator that is essential for maintaining immune homeostasis. This study aimed to examine the role of TIPE2 in isoflurane-induced postoperative cognitive decline (POCD)
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Leptin ameliorates Aβ1-42-induced Alzheimer's disease by suppressing inflammation via activating p-Akt signaling pathway. Trans. Neurosci. (IF 2.1) Pub Date : 2023-04-06 Lin Lu,Zijuan Fu,Bing Wu,Dongsen Zhang,Ying Wang
Background Alzheimer's disease (AD) is characterized by progressive neuronal loss, cognitive disorder, and memory decline. Leptin has been reported to have a neuroprotective effect on neurodegenerative diseases. Objective Our aim was to investigate whether intraperitoneal injection of leptin has a neuroprotective effect and to explore its underlying mechanisms in the AD mouse model. Methods Aβ1-42
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Middle cerebral artery dynamic cerebral autoregulation is impaired by infarctions in the anterior but not the posterior cerebral artery territory in patients with mild strokes. Trans. Neurosci. (IF 2.1) Pub Date : 2023-04-01 Manuel Bolognese,Grzegorz Karwacki,Mareike Österreich,Martin Müller,Lehel Lakatos
Objective The aim of this study was to ascertain whether dynamic cerebral autoregulation (CA) in the middle cerebral artery (MCA) is disturbed by cerebral infarctions outside the MCA territory. Methods We estimated transfer function parameters gain and phase from simultaneous recordings of spontaneous oscillation in blood pressure and MCA cerebral blood flow velocity in 10 consecutive patients with
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Enriched environment can reverse chronic sleep deprivation-induced damage to cellular plasticity in the dentate gyrus of the hippocampus. Trans. Neurosci. (IF 2.1) Pub Date : 2023-03-21 Xue Shixing,Hou Xueyan,Ren Yuan,Tang Wei,Wang Wei
Objective We studied whether enriched environment (EE), a classic epigenetics paradigm, can prevent cellular plasticity damage caused by chronic sleep deprivation (SD). Methods We performed SD in mice by a modified multi-platform method (MMPM). Mice in the SD group were deprived of sleep for 18 h a day. In addition, half of the mice in the chronic SD group were exposed to EE stimuli for 6 h per day
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The correlation between non-arteritic anterior ischemic optic neuropathy and cerebral infarction. Trans. Neurosci. (IF 2.1) Pub Date : 2023-03-18 Xiaochun Li,Xiaolu Cao,Fenglou Ma,Peipei Jia,Fuyin Wang,Xiaoguang Cao
Background The aim of this study was to explore the correlation between non-arteritic anterior ischemic optic neuropathy (NAION) and cerebral infarction (CI). Moreover, the ocular and systemic parameters are also compared between NAION patients with or without CI. Methods Retrospective analysis is performed for NAION patients and the controls. The controls were collected at the eye outpatient with
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Translation of surface electromyography to clinical and motor rehabilitation applications: The need for new clinical figures. Trans. Neurosci. (IF 2.1) Pub Date : 2023-03-14 Roberto Merletti,Federico Temporiti,Roberto Gatti,Sanjeev Gupta,Giorgio Sandrini,Mariano Serrao
Advanced sensors/electrodes and signal processing techniques provide powerful tools to analyze surface electromyographic signals (sEMG) and their features, to decompose sEMG into the constituent motor unit action potential trains, and to identify synergies, neural muscle drive, and EEG-sEMG coherence. However, despite thousands of articles, dozens of textbooks, tutorials, consensus papers, and European
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Omega-3 polyunsaturated fatty acids alleviate early brain injury after traumatic brain injury by inhibiting neuroinflammation and necroptosis. Trans. Neurosci. (IF 2.1) Pub Date : 2023-03-06 Yali Wu,Jing Zhang,Xiaoyan Feng,Wei Jiao
Presently, traumatic brain injury (TBI) is a leading contributor to disability and mortality that places a considerable financial burden on countries all over the world. Docosahexaenoic acid and eicosapentaenoic acid are two kinds of omega-3 polyunsaturated fatty acids (ω-3 PUFA), both of which have been shown to have beneficial biologically active anti-inflammatory and antioxidant effects. However
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HIF-1α participates in secondary brain injury through regulating neuroinflammation. Trans. Neurosci. (IF 2.1) Pub Date : 2023-02-09 Xiaojian Xu,Mengshi Yang,Bin Zhang,Jinqian Dong,Yuan Zhuang,Qianqian Ge,Fei Niu,Baiyun Liu
A deeper understanding of the underlying biological mechanisms of secondary brain injury induced by traumatic brain injury (TBI) will greatly advance the development of effective treatments for patients with TBI. Hypoxia-inducible factor-1 alpha (HIF-1α) is a central regulator of cellular response to hypoxia. In addition, growing evidence shows that HIF-1α plays the important role in TBI-induced changes
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Nanotechnology-based drug delivery for the treatment of CNS disorders. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-31 Khushi R Mittal,Nandini Pharasi,Bhavya Sarna,Manisha Singh,Rachana,Shazia Haider,Sachin Kumar Singh,Kamal Dua,Saurabh Kumar Jha,Abhijit Dey,Shreesh Ojha,Shalini Mani,Niraj Kumar Jha
Approximately 6.8 million people die annually because of problems related to the central nervous system (CNS), and out of them, approximately 1 million people are affected by neurodegenerative diseases that include Alzheimer's disease, multiple sclerosis, epilepsy, and Parkinson's disease. CNS problems are a primary concern because of the complexity of the brain. There are various drugs available to
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Brain and gut microbiota disorders in the psychopathology of anorexia nervosa. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-31 Mercedes Garcia-Gil,Maria Rachele Ceccarini,Fabrizio Stoppini,Samuela Cataldi,Claudia Mazzeschi,Elisa Delvecchio,Elisabetta Albi,Giulia Gizzi
Studies of pathophysiological mechanisms involved in eating disorders (EDs) have intensified over the past several years, revealing their unprecedented and unanticipated complexity. Results from many articles highlight critical aspects in each member of ED family. Notably, anorexia nervosa (AN) is a disorder due to undefined etiology, frequently associated with symptoms of depression, anxiety, obs
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The possible association between neurodegenerative/demyelinating neurological disorders in achalasia patients. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-31 Salim T Khoury,Amir Mari
The precise pathogenesis of achalasia is still unclear. Neurodegenerative and/or demyelinating disorders (NDD) appear to share some common pathophysiological pathways described in achalasia such as inflammation, autoimmune, mitochondrial dysfunction, and neurodegeneration. Jerie et al. have published on the October issue a prospective study assessing the prevalence of several NDD in achalasia patients
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Fronto-parietal single-trial brain connectivity benefits successful memory recognition. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-31 Soyeon Jun,Yihyun Joo,Youjin Sim,Chuyun Pyo,Keunsoo Ham
Successful recognition has been known to produce distinct patterns of neural activity. Many studies have used spectral power or event-related potentials of single recognition-specific regions as classification features. However, this does not accurately reflect the mechanisms behind recognition, in that recognition requires multiple brain regions to work together. Hence, classification accuracy of
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Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-29 Zhen-Kun Gao,Xin-Ya Shen,Yu Han,Yi-Sha Guo,Kai Li,Xia Bi
Introduction Mitogen-activated protein kinase (MAPK) pathway is a major mechanism of acute brain damage in ischemic stroke. Pre-ischemic exercise is an effective method to reduce ischemic injury. However, the regulation by pre-ischemic exercise of MAPK pathway and associated mechanisms in animal models remains unclear. Materials and methods In this study, Male SD rats were randomly divided into sham
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Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-21 Xin Zhang,Lijun Xu,Xiang Chen,Xianjie Zhou,Lanhua Cao
Spinal cord injury (SCI) is a severe central nervous system disease, which may cause serious locomotor deficit. Acacetin is a flavone that possesses antioxidant and anti-inflammatory effects in different human diseases. The main purpose of this study was to explore whether acacetin ameliorates SCI in mice. A model of SCI was established in C57BL/6 mice. The Basso Mouse Scale (BMS) score, BMS subscore
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The value of transcranial Doppler monitoring of cerebral blood flow changes during carotid endarterectomy performed under regional anesthesia - A case series. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-16 Zoltán Gyöngyösi,Orsolya Farkas,Lóránd Papp,Fruzsina Bodnár,Tamás Végh,Béla Fülesdi
Recent evidence suggests no difference between patient outcomes when carotid endarterectomies (CEAs) are performed under general or regional anesthesia. However, for detecting the need for a shunt, general anesthesia has the drawback of monitoring needs in the intraoperative setting. In the present study, we attempted to perform intraoperative transcranial Doppler (TCD) monitoring for CEAs performed
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A rare lymphoplasmacyte-rich meningioma involving the dura of the skull base and cervical spinal cord: A case report. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-13 Siyao Zhu,Yuting Zou,Ya Wang,Gongxun Xie,Shengying Xiao,Furen Zeng,Yichen Lu
Lymphoplasmacyte-rich meningioma (LPRM) is a rare subtype of meningioma, the specific pathogenesis of which remains unclear. Herein, we report the case of a 48-year-old Asian man who experienced progressive deafness and limb weakness. Magnetic resonance imaging revealed extramedullary masses diffusely growing, wrapping, and compressing the cervical spinal cord. The dural lesion was partially excised
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Application of auditory mismatch negativity in tinnitus patients based on high-resolution electroencephalogram signals. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-08 Kunkun Wang,Xiaoling Lu,Shan Sun
Objective The purpose of this study was to investigate the significance of mismatch negativity (MMN) by comparing high-resolution electroencephalogram signals from tinnitus patients and healthy controls. Methods The study included eight subjects with chronic subjective idiopathic tinnitus and seven healthy controls. Participants with clinical speech (512-2,000 Hz) hearing thresholds less than 25 dB
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Factors influencing recovery of upper limb motor function during constraint-induced movement therapy for people with stroke. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-08 Auwal Abdullahi,Bishir Sabo,Umaru Muhammad Badaru,Wim Saeys,Steven Truijen
Objective The aim of this study is to determine the personal and clinical factors that can predict recovery of motor function in people with stroke. Methods Characteristics of the study participants such as age, sex, time since stroke and type of stroke, motor function, shoulder pain, amount and quality of use of the affected limb in the real world, wrist and elbow spasticity, handedness, central post-stroke
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Correlations between EEG and intestinal electrical stimulation. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-06 Nora Vanessa de Camp,Jürgen Bergeler
Many diseases affect the autonomous nervous system and the central nervous system simultaneously, for example Parkinson's disease or irritable bowel syndrome. To study neurophysiologic interactions between the intestinal electrical activity and the electroencephalography (EEG) pattern of the brain, we combined intestinal electrical stimulation (IES) and non-invasive telemetric full-band DC EEG recordings
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Esketamine improves propofol-induced brain injury and cognitive impairment in rats. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-06 Guiping Xu,Yang Wang,Zhe Chen,Yuxuan Zhang,Xuexue Zhang,Guichao Zhang
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. Esketamine is a sedative that has been proven to have an antidepressant effect. However, its effect on propofol-induced neurotoxicity and
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Mild acute stress prevents the memory impairment induced by long-term isoflurane anesthesia. Trans. Neurosci. (IF 2.1) Pub Date : 2022-12-01 Tiantian Liu,Yutong Dai,Minhui Xu,Ying Chen,Tianjiao Xia,Xin Zhao
Objectives Long-term isoflurane anesthesia exposure could result in postoperative cognitive dysfunction (POCD). Preoperative stress is also reported to be a risk factor of POCD. However, it is unknown whether acute stress could impair memory after long-term isoflurane anesthesia. Methods In this study, we categorized the mice with acute stress into mild (30 min restraint stress), moderate (60 min restraint
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Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex. Trans. Neurosci. (IF 2.1) Pub Date : 2022-11-30 Abdulrahman Alhamyani,Prabhat R Napit,Khaggeswar Bheemanapally,Paul W Sylvester,Karen P Briski
Brain metabolic-sensory targets for modulatory glucose-sensitive endocrine and neurochemical signals remain unidentified. A hypothalamic astrocyte primary culture model was here used to investigate whether glucocorticoid receptor (GR) and noradrenergic signals regulate astrocyte glucose (glucose transporter-2 [GLUT2], glucokinase) and/or energy (5'-AMP-activated protein kinase [AMPK]) sensor reactivity