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  • The Ontario Neurodegenerative Disease Research Initiative
    medRxiv. Neurol. Pub Date : 2020-08-02
    Kelly M Sunderland; Derek Beaton; Stephen R Arnott; Peter Kleinstiver; Donna Kwan; Jane M Lawrence-Dewar; Joel Ramirez; Brian Tan; Robert Bartha; Sandra E Black; Michael Borrie; Donald Brien; Leanne K Casaubon; Brian Coe; Benjamin Cornish; Allison A Dilliott; Dar Dowlatshahi; Elizabeth Finger; Corinne Fischer; Andrew Frank; Julia Fraser; Morris Freedman; Barry Greenberg; David A Grimes; Ayman Hassan;

    Objective: In individuals over the age of 65, concomitant neurodegenerative pathologies contribute to cognitive and/or motor decline and can be aggravated by cerebrovascular disease, but our understanding of how these pathologies synergize to produce the decline represents an important knowledge gap. The Ontario Neurodegenerative Disease Research Initiative (ONDRI), a multi-site, longitudinal, observational

    更新日期:2020-08-02
  • Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography
    medRxiv. Neurol. Pub Date : 2020-08-01
    Viktor Sip; Meysam Hashemi; Anirudh N Vattikonda; Marmaduke Woodman; Huifang Wang; Julia Scholly; Samuel Medina Villalon; Maxime Guye; Fabrice Bartolomei; Viktor K Jirsa

    Surgical interventions in epileptic patients aimed at the removal of the epileptogenic zone have success rates at only 60-70%. This failure can be partly attributed to the insufficient spatial sampling by the implanted intracranial electrodes during the clinical evaluation, leading to an incomplete picture of spatio-temporal seizure organization in the regions that are not directly observed. Utilizing

    更新日期:2020-08-02
  • KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer's disease
    medRxiv. Neurol. Pub Date : 2020-07-31
    Julia Neitzel; Nicolai Franzmeier; Anna Rubinski; Martin Dichgans; Matthias Brendel; Rainer Malik; Michael Ewers; Alzheimer's Disease Neuroimaging Initiative (ADNI)

    Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer's disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e. the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VShet and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-assessed

    更新日期:2020-08-01
  • Central Nervous System Manifestations in COVID-19 Patients: A Systematic Review and Meta-analysis
    medRxiv. Neurol. Pub Date : 2020-07-29
    Shahrzad Nazari; Amirhossein Azari Jafari; Seyyedmohammadsadeq Mirmoeeni; Saeid Sadeghian; Mohammad Eghbal Heidari; Siavash Sadeghian; Farhad Asarzadegan; Seyed Mahmoud Puormand; Hamid Ebadi; Davood Fathi; Sahar Dalvand

    Background: At the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID-19 initially reported in China, and later known as COVID-19, led to a global pandemic. Despite many studies reporting respiratory infections as the primary manifestations of this illness, an increasing number of investigations have focused on the central nervous system (CNS) manifestations

    更新日期:2020-07-30
  • Mononeuritis multiplex: an unexpectedly common feature of severe COVID-19
    medRxiv. Neurol. Pub Date : 2020-07-29
    Edward Needham; Virginia Newcombe; Andrew Michell; Rachel Thornton; Andrew Grainger; Fahim Anwar; Elizabeth Warburton; David Menon; Monica Trivedi; Stephen Sawcer

    The prolonged mechanical ventilation required by patients with severe COVID-19 is expected to result in significant Intensive Care Unit - Acquired Weakness (ICUAW) in many of the survivors. However, in our post-COVID-19 follow up clinic we have found that, as well as the anticipated global weakness related to loss of muscle mass, a significant proportion of these patients also have disabling focal

    更新日期:2020-07-29
  • Pharmacological and Non-Pharmacological Interventions to Enhance Sleep in Mild Cognitive Impairment and Mild Alzheimer s Disease: A Systematic Review
    medRxiv. Neurol. Pub Date : 2020-07-29
    Jonathan Blackman; Marta Swirski; James Clynes; Sam Harding; Yue Leng; Elizabeth Coulthard

    Suboptimal sleep causes cognitive decline and probably accelerates Alzheimer s Disease (AD) progression. Several sleep interventions have been tested in established AD dementia cases. However early intervention is needed in the course of AD at Mild Cognitive Impairment (MCI) or mild dementia stages to help prevent decline and maintain good quality of life. This systematic review aims to summarize evidence

    更新日期:2020-07-29
  • Evaluation of plasma tau and neurofilament light chain biomarkers in a 12-year clinical cohort of human prion diseases
    medRxiv. Neurol. Pub Date : 2020-07-29
    Andrew Thompson; Prodromos Anastasiadis; Ron Druyeh; Ines Whitworth; Annapurna Nayak; Akin Nihat; Tzehow Mok; Peter Rudge; Jonathan Wadsworth; Jonathan Rohrer; Jonathan Schott; Amanda Heslegrave; Henrik Zetterberg; John Collinge; Graham Jackson; Simon H Mead

    Prion diseases are fatal neurodegenerative conditions with highly accurate CSF and imaging diagnostic markers, but major unmet needs for blood biomarkers. Using ultrasensitive immuno-assays, we measured tau and neurofilament light chain (NfL) protein concentrations in 709 plasma samples taken from 377 individuals with prion disease during a 12-year prospective clinical study, alongside healthy and

    更新日期:2020-07-29
  • SARS-CoV-2 Infection and Stroke: Coincident or Causal?
    medRxiv. Neurol. Pub Date : 2020-07-29
    Melanie Walker; Christopher C. Young; Malveeka Sharma; Michael R Levitt; David L Tirschwell; WWAMI Stroke Investigators

    Neurological manifestations of SARS-CoV-2 infection described in isolated case reports and single institutions do not accurately reflect the clinical spectrum of disease across all geographies in a global pandemic. Data collected during peak of the Covid-19 pandemic from stroke centers in five states reveal few similarities to what has recently been published. Given the diversity in phenotype, we caution

    更新日期:2020-07-29
  • Complex Autoantibody Responses Occur Following Moderate to Severe Traumatic Brain Injury
    medRxiv. Neurol. Pub Date : 2020-07-27
    Edward J Needham; Oda Stoevesandt; Eric P Thelin; Henrik Zetterberg; Elisa R Zanier; Faiez Al Nimer; Nicholas J Ashton; Joanne G Outtrim; Virginia FJ Newcombe; Hani S Mousa; Joel Simren; Kaj Blennow; Zhihui Yang; Peter J Hutchinson; Fredrik Piehl; Adel Helmy; Mike Taussig; Kevin KW Wang; Joanne L Jones; David K Menon; Alasdair Coles

    The majority of variation in outcome following severe traumatic brain injury (TBI) remains unexplained by currently recognised prognostic factors, suggesting a contribution from unaccounted variables. One key candidate variable is neuroinflammation, including the generation of autoantibodies against brain specific antigens which have been described in some individuals following TBI. Here we hypothesised

    更新日期:2020-07-27
  • Similarities between the neurological symptoms of COVID-19 and Functional Neurological Disorder: A systematic overview of systematic reviews and implications for future neurological healthcare services
    medRxiv. Neurol. Pub Date : 2020-07-27
    Tamar Wildwing; Nicole Holt

    Background: COVID-19, a novel coronavirus, spread rapidly across the world from December 2019. While the main symptoms of the disease are respiratory, extensive research has realised evidence of a variety of neurological symptoms, both catastrophic such as cerebrovascular disease and benign such as hyposmia (loss of smell). Aim: To provide health professionals with better accessibility to available

    更新日期:2020-07-27
  • The left inferior frontal gyrus is causally involved in selective semantic retrieval: Evidence from tDCS in primary progressive aphasia
    medRxiv. Neurol. Pub Date : 2020-07-26
    Zeyi Wang; Bronte N Ficek; Kimberly T Webster; Chiadi U Onyike; John E Desmond; Argye E Hillis; Constantine E Frangakis; Brian Caffo; Kyrana Tsapkini

    Lesion and imaging studies have shown that the left inferior frontal gyrus (IFG) is involved in selective semantic retrieval of information from the temporal lobes. However, causal, i.e., interventional, evidence is sparse. In the present study we addressed this question by testing whether transcranial direct current stimulation (tDCS) over the left IFG in a group of individuals with primary progressive

    更新日期:2020-07-26
  • Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity
    medRxiv. Neurol. Pub Date : 2020-07-26
    Patrick Ostkamp; Anke Salmen; Beatrice Pignolet; Dennis Goerlich; Till F. M. Andlauer; Andreas Schulte-Mecklenbeck; Gabriel Gonzalez-Escamilla; Florence Buciarelli; Isabelle Gennero; Johanna Breuer; Gisela Antony; Tilman Schneider-Hohendorf; Nadine Mykicki; Antonios Bayas; Florian Then Bergh; Stefan Bittner; Hans-Peter Hartung; Manuel A. Friese; Ralf Linker; Felix Luessi; Klaus Lehmann-Horn; Mark Muehlau;

    Background: Multiple sclerosis (MS) disease risk is associated with reduced sun exposure. This study assessed the relationship between measures of sun-exposure (vitamin D (vitD), latitude) and MS disease severity, the mechanisms of action, and effect-modification by medication and sun-sensitivity associated MC1R variants. Methods: Two multi-center cohort studies (nNationMS=946, nBIONAT=991). Outcomes

    更新日期:2020-07-26
  • Mild cognitive impairment is associated with skeletal muscle mitochondrial deficits
    medRxiv. Neurol. Pub Date : 2020-07-25
    Jill K Morris; Colin S. McCoin; Kelly N. Fuller; Casey S. John; Heather M. Wilkins; Xiaowan Wang; Palash Sharma; Jeffrey M. Burns; Eric D. Vidoni; Jonathan D Mahnken; Russell H. Swerdlow; John P. Thyfault

    Alzheimer's Disease (AD) is associated with insulin resistance and low cardiorespiratory fitness, suggestive of impaired skeletal muscle mitochondrial function. We examined if individuals with Mild Cognitive Impairment (MCI), the earliest phase of AD-related cognitive decline, exhibit reduced skeletal muscle mitochondrial function, and if AD medication impacted outcomes. We present data from 50 individuals

    更新日期:2020-07-26
  • Theta and gamma activity is linked with affective and cognitive symptoms in Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-07-25
    Kartik K Iyer; Tiffany R Au; Anthony J Angwin; David A Copland; Nadeeka N Dissanayaka

    Background The progression of Parkinsons disease (PD) can often exacerbate symptoms of depression, anxiety, and/or cognitive impairment. In this study, we explore the possibility that multiple brain network responses are associated with symptoms of depression, anxiety and cognitive impairment in PD. This association is likely to provide insights into a single multivariate relationship, where common

    更新日期:2020-07-26
  • Dynamic Analysis on Simultaneous iEEG-MEG Data via Hidden Markov Model
    medRxiv. Neurol. Pub Date : 2020-07-25
    Siqi Zhang; Chunyan Cao; Andrew Quinn; Umesh Vivekananda; Shikun Zhan; Wei Liu; Boming Sun; Mark W Woolrich; Qing Lu; Vladimir Litvak

    Background: Intracranial electroencephalography (iEEG) recordings are used for clinical evaluation prior to surgical resection of the focus of epileptic seizures and also provide a window into normal brain function. While these recordings afford detailed information about local brain activity, putting this activity in context and comparing results across patients is challenging. Non-invasive whole-brain

    更新日期:2020-07-25
  • Thalamohippocampal atrophy in focal epilepsy of unknown cause at the time of diagnosis
    medRxiv. Neurol. Pub Date : 2020-07-25
    Nicola J. Leek; Barbara A. K. Kreilkamp; Mollie Neason; Christophe de Bezenac; Besa Ziso; Samia Elkommos; Kumar Das; Anthony G. Marson; Simon S. Keller

    Background: Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed focal epilepsy (NDfE), despite it being a crucial point in time for understanding the underlying biology of the disorder. We aimed to determine whether patients with NDfE show evidence

    更新日期:2020-07-25
  • Neuroanatomic markers of post-traumatic epilepsy based on magnetic resonance imaging and machine learning
    medRxiv. Neurol. Pub Date : 2020-07-24
    Haleh Akrami; Richard M Leahy; Andrei Irimia; Paul E Kim; Christianne Heck; Anand Joshi

    Although post-traumatic epilepsy (PTE) is a common complication of traumatic brain injury (TBI), the relationship between these conditions is unclear, early PTE detection and prevention being major unmet clinical challenges. This study aims to identify imaging biomarkers that distinguish PTE and non-PTE subjects among TBI survivors based on a magnetic resonance imaging (MRI) dataset. We performed tensor-based

    更新日期:2020-07-25
  • Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome
    medRxiv. Neurol. Pub Date : 2020-07-24
    Stephen Keddie; Julia Pakpoor; Christina Mousele; Menelaos Pipis; Pedro M Machado; Mark Foster; Christopher J Record; Ryan Keh; Janev Fehmi; Ross W Paterson; Viraj Bharambe; Lisa Clayton; Claire Allen; Olivia Price; Jasmine Wall; Annamaria Kiss-csenki; Dipa P Rathnasabapathi; Ruth Geraldes; Tatyana Yermakova; Josh King-Robson; Maya Zosmer; Sanjeev Rajakulendran; Ross Nortley; Charles Marshall; Edward

    Background Reports of Guillain-Barre Syndrome (GBS) have emerged during the Coronavirus Disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to investigate any causative association between COVID-19 infection and GBS. Methods The epidemiology of GBS cases reported via the UK National Immunoglobulin Database were studied from 2016-2019 and compared to cases reported during

    更新日期:2020-07-25
  • Plasma amyloid, phosphorylated tau, and neurofilament light for individualized risk prediction in mild cognitive impairment
    medRxiv. Neurol. Pub Date : 2020-07-24
    Nicholas C. Cullen; Antoine Leuzy; Sebastian Palmqvist; Shorena Janelidze; Erik Stomrud; Pedro Pesini; Leticia Sarasa; Jose Antonio Allue; Nicholas K. Proctor; Henrik Zetterberg; Jeffrey L. Dage; Kaj Blennow; Niklas Mattsson-Carlgren; Oskar Hansson

    We developed models for individualized risk prediction of cognitive decline in mild cognitive impairment (MCI), using plasma biomarkers of beta-amyloid (Ab), tau, and neurodegeneration. We included MCI patients from the Swedish BioFINDER study (n=148) and the Alzheimer's Disease Neuroimaging Initiative (ADNI; n=86 for model selection; n=425 for prognostic validation). The primary outcomes were longitudinal

    更新日期:2020-07-24
  • Cerebral Microvascular Injury in Severe COVID-19
    medRxiv. Neurol. Pub Date : 2020-07-24
    John Conklin; Matthew P. Frosch; Shibani Mukerji; Otto Rapalino; Mary Maher; Pamela W. Schaefer; Michael H. Lev; Ramon G. Gonzalez; Sudeshna Das; Samantha N. Champion; Colin Magdamo; Pritha Sen; George Kyle Harrold; Haitham Alabsi; Erica Normandin; Bennett Shaw; Jacob Lemieux; Pardis Sabeti; John A. Branda; Emery N. Brown; M. Brandon Westover; Susie Y. Huang; Brian L Edlow

    IMPORTANCE: Microvascular lesions are common in patients with severe COVID-19. Radiologic-pathologic correlation in one case suggests a combination of microvascular hemorrhagic and ischemic lesions that may reflect an underlying hypoxic mechanism of injury, which requires validation in larger studies. OBJECTIVE: To determine the incidence, distribution, and clinical and histopathologic correlates of

    更新日期:2020-07-24
  • Abnormalities in cortical pattern of coherence in interictal migraine detected using ultra high-density EEG
    medRxiv. Neurol. Pub Date : 2020-07-20
    Alireza Chamanzar; Sarah M Haigh; Pulkit Grover; Marlene Behrmann

    Individuals with migraine generally experience photophobia and/or phonophobia during and between migraine attacks. Many different mechanisms have been postulated to explain these migraine phenomena including abnormal patterns of connectivity across the cortex. The results, however, remain contradictory and there is no clear consensus on the nature of the cortical abnormalities in migraine. Here, we

    更新日期:2020-07-20
  • An optimal 1H-MRS technique at 7T: Proof-of-principle in Chronic Multiple Sclerosis and Neuromyelitis Optica Brain Lesions and Normal Appearing Brain Tissue.
    medRxiv. Neurol. Pub Date : 2020-07-20
    George Tackley; Yazhuo Kong; Rachel Minne; Silvia Messina; Anderson Winkler; Ana Cavey; Rosie Everett; Gabriele C DeLuca; Andrew Weir; Matthew Craner; Irene Tracey; Jacqueline Palace; Charlotte Stagg; Uzay Emir

    Magnetic Resonance Spectroscopy (MRS) allows for the non-invasive quantification of neurochemicals and has the potential to differentiate between the pathologically distinct diseases, multiple sclerosis (MS) and AQP4Ab-positive neuromyelitis optica spectrum disorder (AQP4Ab-NMOSD). In this study we characterised the metabolite profiles of brain lesions in 11 MS and 4 AQP4Ab-NMOSD patients using an

    更新日期:2020-07-20
  • Alzheimer s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
    medRxiv. Neurol. Pub Date : 2020-07-20
    Vincenzo Muto; Ekaterina Koshmanova; Pouya Ghaemmaghami; Mathieu Jaspar; Christelle Meyer; Mahmoud Elansary; Maxime Van Egroo; Daphne Chylinski; Christian Berthomier; Marie Brandewinder; Charlotte Mouraux; Christina Schmidt; Gregory Hammad; Wouter Coppieters; Naima Ahariz; Christian Degueldre; Andre Luxen; Eric Salmon; Christophe Phillips; Simon N Archer; Loic Yengo; Enda Byrne; Fabienne Collette;

    Study Objectives. Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer s disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. Methods. We computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under different

    更新日期:2020-07-20
  • A phenome-wide association study identifying risk factors for pediatric post-concussion syndrome
    medRxiv. Neurol. Pub Date : 2020-07-17
    Aaron M Yengo-Kahn; Natalie Hibshman; Christopher M Bonfield; Eric S Torstenson; Katherine A Gifford; Daniil Belikau; Lea K Davis; Scott L Zuckerman; Jessica K Dennis

    Objective: To identify risk factors and generate hypotheses for pediatric post-concussion syndrome (PCS) using a phenome-wide association study (PheWAS). Methods: A PheWAS (case-control) was conducted following the development and validation of a novel electronic health record-based algorithm that identified PCS cases and controls from an institutional database of >2.8 million patients. Cases were

    更新日期:2020-07-18
  • Confirmed central olfactory system lesions on brain MRI in COVID-19 patients with anosmia: a case-series
    medRxiv. Neurol. Pub Date : 2020-07-17
    Yannick Girardeau; Yoan GALLOIS; Guillaume DE BONNECAZE; Bernard ESCUDE; Clarisse LAFONT; Gilles CHATELLIER; Mathieu MARX

    Objective: Anosmia has been listed as a key-symptom associated with the COVID-19 infection. Because it often occurs without any sign of rhinitis, lesions of the central olfactory system have been suspected. To date, however, there is no evidence that anosmia caused by SARS-CoV2 could be the result of brain damage. Methods: We conducted a case-series on 10 consecutive COVID-19 patients who reported

    更新日期:2020-07-18
  • The Effect of the COVID-19 Pandemic on People with Parkinson's Disease
    medRxiv. Neurol. Pub Date : 2020-07-17
    Ethan G Brown; Lana M Chahine; Samuel M. Goldman; Monica Korell; Emerald Mann; Daniel R. Kinel; Vanessa Arnedo; Kenneth L. Marek; Caroline M Tanner

    Objective: To rapidly identify areas of need and improve care in people with Parkinson's disease (PwPD) affected by the COVID-19 pandemic, we deployed a survey focusing on the presentation and complications of COVID-19 infection and the effect of the COVID-19 pandemic among those not infected. Methods: Individuals with and without PD participating in the online study Fox Insight (FI) were invited to

    更新日期:2020-07-17
  • Genetic risk for Alzheimer's disease influences neuropathology via multiple biological pathways
    medRxiv. Neurol. Pub Date : 2020-07-17
    Eilis Hannon; Gemma L Shireby; Keeley Brookes; Johannes Attems; Rebecca Sims; Nigel J Cairns; Seth Love; Alan J Thomas; Kevin Morgan; Paul T Francis; Jonathan Mill

    Alzheimer's disease is a highly heritable, common neurodegenerative disease characterised neuropathologically by the accumulation of β-amyloid plaques and tau-containing neurofibrillary tangles. In addition to the well-established risk associated with the APOE locus, there has been considerable success in identifying additional genetic variants associated with Alzheimer's disease. Major challenges

    更新日期:2020-07-17
  • Acute Demyelinating Encephalomyelitis (ADEM) in COVID-19 infection: A Case Series.
    medRxiv. Neurol. Pub Date : 2020-07-17
    Michaela McCuddy; Praful Kelkar; Yu Zhao; David Wicklund

    Objective: To report three patients infected with COVID-19 with severe respiratory syndrome requiring intubation, who developed acute demyelinating encephalomyelitis (ADEM). Method: Patient data were obtained from medical records from the North Memorial Health Hospital, Robbinsdale, MN, USA Results: Three patients (two men and one woman, aged 38 - 63) presented with fatigue, cough and fever leading

    更新日期:2020-07-17
  • Systematic identification of modifiable risk factors and drug repurposing options for Alzheimer's disease: Mendelian randomization analyses
    medRxiv. Neurol. Pub Date : 2020-07-16
    Chong Wu; Lang Wu; Jingshen Wang; Lifeng Lin; Yanming Li; Qing Lu; Hong-Wen Deng

    Introduction: Several Mendelian randomization studies have been conducted, which identified multiple risk factors for Alzheimer's disease (AD). However, they typically focus on a few pre-selected risk factors. Methods: Two-sample Mendelian randomization (MR) study was used to systematically examine the potential causal associations of 1,054 risk factors/medical conditions and 28 drugs with the risk

    更新日期:2020-07-16
  • Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative
    medRxiv. Neurol. Pub Date : 2020-07-16
    Thomas K Karikari; Andréa L. Benedet; Nicholas J Ashton; Juan Lantero Rodriguez; Anniina Snellman; Marc Suárez-Calvet; Paramita Saha Chaudhuri; Firoza Lussier; Hlin Kvartsberg; Alexis Moscoso Rial; Tharick A Pascoal; Ulf Andreasson; Michael K Schöll; Pedro Rosa-Neto; Kaj Blennow; Henrik Zetterberg; Alzheimer's Disease Neuroimaging Initiative

    Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-beta and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad implementation in clinical and trial settings are restricted by high cost and limited accessibility. Plasma phosphorylated-tau181 (p-tau181) is a promising blood-based biomarker that is specific for AD, correlates

    更新日期:2020-07-16
  • Sleep quality, mental health and circadian rhythms during COVID lockdown: Results from the SleepQuest Study
    medRxiv. Neurol. Pub Date : 2020-07-15
    Neil Carrigan; Alfie R Wearn; Saba Meky; James Selwood; Hugh Piggins; Nicholas Turner; Rosemary Greenwood; Elizabeth Coulthard

    Behavioural responses to COVID19 lockdown will define the long-term impact of psychological stressors on sleep and brain health. Here we tease apart factors that help protect against sleep disturbance. We capitalise on the unique restrictions during COVID19 to understand how time of day of daylight exposure and outside exercise interact with chronotype and sleep quality. 3474 people from the UK (median

    更新日期:2020-07-16
  • In vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies
    medRxiv. Neurol. Pub Date : 2020-07-15
    Carla Palleis; Julia Sauerbeck; Leonie Beyer; Stefanie Harris; Julia Schmitt; Estrella Morenas-Rodriguez; Anika Finze; Alexander Nitschmann; Francois Ruch-Rubinstein; Florian Eckenweber; Gloria Biechele; Tanja Blume; Yuan Shi; Endy Weidinger; Catharina Prix; Kai Boetzel; Adrian Danek; Boris Rauchmann; Sophia Stoecklein; Marcus Unterrainer; Nathalie L. Albert; Christian Wetzel; Rainer Rupprecht; Axel

    Objective: The aim of this cross−sectional single center study was to investigate 18kDa translocator protein (TSPO)−PET as a biomarker for microglial activation in the 4−repeat tauopathies corticobasal degeneration and progressive supranuclear palsy (PSP). Methods: Specific binding of the TSPO tracer 18F−GE−180 was determined by serial PET during pharmacological depletion of microglia in a 4−repeat

    更新日期:2020-07-15
  • Clinical Electroencephalography Findings and Considerations in Hospitalized Patients with Coronavirus SARS-CoV-2
    medRxiv. Neurol. Pub Date : 2020-07-15
    Neishay Ayub; Joseph Cohen; Jin Jing; Aayushee Jain; Ryan Tesh; Shibani S. Mukerji; Sahar F. Zafar; M. Brandon Westover; Eyal Y Kimchi

    Background and Purpose Reports have suggested that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes neurologic manifestations including encephalopathy and seizures. However, there has been relatively limited electrophysiology data to contextualize these specific concerns and to understand their associated clinical factors. Our objective was to identify EEG abnormalities present in

    更新日期:2020-07-15
  • The Canadian ALS Neuroimaging Consortium (CALSNIC) - a multicentre platform for standardized imaging and clinical studies in ALS
    medRxiv. Neurol. Pub Date : 2020-07-15
    Sanjay Kalra; Muhammad Umer Khan; Laura Barlow; Christian Beaulieu; Michael Benatar; Hannah Briemberg; Sneha Chenji; Miriam Garrido Clua; Andre Cormier; Sumit Das; Annie Dionne; Nicholas Dupre; Derek Emery; Dean Eurich; Richard Frayne; Angela Genge; Summer Gibson; Simon Graham; Christopher Hanstock; Abdullah Ishaque; Jeffrey T. Joseph; Julia Keith; Lawrence Korngut; Dennell Krebs; Cheryl R. McCreary;

    Background: Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. Increasing age is an important risk factor for developing ALS, thus the societal impact of this devastating disease will become more profound as the population ages. A significant hurdle to finding effective treatment has been an inability to accurately quantify cerebral degeneration associated

    更新日期:2020-07-15
  • MIND diet associated with later onset of Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-07-14
    Avril Metcalfe-Roach; Adam Yu; Ella Golz; Kristen Sundvick; Mihai Cirstea; Daniel Kliger; Liam Foulger; Melissa Mackenzie; Brett Finlay; Silke Cresswell

    Background: The MIND diet has been linked with prevention of cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). Objective: To determine whether MIND diet adherence is associated with the age of Parkinson's disease onset. Methods: Food Frequency Questionnaires from 181 participants with PD were scored for MIND adherence and correlated with age of onset using

    更新日期:2020-07-14
  • Time course of phosphorylated tau181 in blood across the Alzheimer's disease spectrum
    medRxiv. Neurol. Pub Date : 2020-07-14
    Alexis Moscoso; Michel J. Grothe; Nicholas J. Ashton; Thomas K Karikari; Juan Lantero Rodriguez; Anniina Snellman; Marc Suarez Calvet; Henrik Zetterberg; Kaj Blennow; Michael Schoell

    Tau phosphorylated at threonine 181 (p-tau181) measured in blood plasma has recently been proposed as an accessible, scalable, and highly specific biomarker for Alzheimer's disease. Longitudinal studies, however, investigating the temporal dynamics of this novel biomarker are lacking. It is therefore unclear when in the disease process plasma p-tau181 increases above physiological levels and how it

    更新日期:2020-07-14
  • Novel intraoperative online functional mapping of somatosensory finger representations for targeted stimulating electrode placement
    medRxiv. Neurol. Pub Date : 2020-07-14
    David McMullen; Tessy M Thomas; Matthew S Fifer; Daniel N. Candrea; Francesco V. Tenore; Robert W. Nickl; Eric A. Pohlmeyer; Christopher Coogan; Luke Osborn; Adam Schiavi; Teresa Wojtasiewicz; Chad Gordon; Adam B. Cohen; Nick F. Ramsey; Wouter Schellekens; Sliman Bensmaia; Gabriela L. Cantarero; Pablo A. Celnik; Brock A. Wester; William S. Anderson; Nathan E. Crone

    Defining eloquent cortex intraoperatively, traditionally performed by neurosurgeons to preserve patient function, can now help target electrode implantation for restoring function. Brain-machine interfaces (BMIs) have the potential to restore upper-limb motor control to paralyzed patients but require accurate placement of recording and stimulating electrodes to enable functional control of a prosthetic

    更新日期:2020-07-14
  • Frontal and cerebellar atrophy supports FTSD-ALS clinical continuum
    medRxiv. Neurol. Pub Date : 2020-07-13
    Beatrice Pizzarotti; Fulvia Palesi; Paolo Vitali; Gloria Castellazzi; Nicoletta Anzalone; Elena Alvisi; Daniele Martinelli; Sara Bernini; Matteo Cotta Ramusino; Mauro Ceroni; Giuseppe Micieli; Elena Sinforiani; Egidio D'Angelo; Alfredo Costa; Claudia Angewla Michela Gandini Wheeler-Kingshott

    Background: Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS and ALS patients to further understand this clinical continuum. Methods: We used voxel-based

    更新日期:2020-07-14
  • Effects of High Intensity Interval Exercise on Cerebrovascular Function: A Systematic Review
    medRxiv. Neurol. Pub Date : 2020-07-13
    Alicen A Whitaker; Mohammed Alwatban; Andrea Freemyer; Jaime Perales-Puchalt; Sandra A Billinger

    High intensity interval exercise (HIIE) improves aerobic fitness with decreased exercise time compared to moderate continuous exercise. A gap in knowledge exists regarding the effects of HIIE on cerebrovascular function such as cerebral blood velocity and autoregulation. The objective of this systematic review was to ascertain the effect of HIIE on cerebrovascular function in healthy individuals. We

    更新日期:2020-07-14
  • Quantitative assessment of motor neglect
    medRxiv. Neurol. Pub Date : 2020-07-12
    Monica N. Toba; Chiara Pagliari; Marco Rabuffetti; Norbert Nighoghossian; Gilles Rode; Francois Cotton; Lucia Spinazzola; Francesca Baglio; Raffaella Migliaccio; Paolo Bartolomeo

    Objectives. Patients with unilateral brain damage may avoid moving the limbs contralateral to their lesion, even in the absence of sensorimotor deficits. However, when asked to move their limbs these patients typically show normal strength and dexterity. In their seminal 1983 article on the Journal of Neurology, Neurosurgery and Psychiatry, Laplane and Degos dubbed this condition Motor Neglect (MN)

    更新日期:2020-07-13
  • Accurate classification of secondary progression in multiple sclerosis
    medRxiv. Neurol. Pub Date : 2020-07-11
    Ryan Ramanujam; Feng Zhu; Katharina Fink; Virginija Danylaite Karrenbauer; Johannes Lorscheider; Pascal Benkert; Elaine Kingwell; Helen Tremlett; Jan Hillert; Ali Manouchehrinia; The BeAMS Study group

    Transition from a relapsing-remitting to the secondary progressive phenotype is an important milestone in the clinical evolution of multiple sclerosis. In the absence of reliable imaging or biological markers of phenotype transition, assignment of current phenotype status relies on retrospective evaluation of the medical history of an individual. Here, we sought to determine if demographic and clinical

    更新日期:2020-07-13
  • Brain Malformations in Zika Virus Related Congenital Microcephaly: interactions among clinical and imaging scores and a semi-automated classification of severity based on MRI indices (RaRe - Radiological Reading score)
    medRxiv. Neurol. Pub Date : 2020-07-11
    Nathalia Bianchini Esper; Alexandre Rosa Franco; Ricardo Bernardi Soder; Rodrigo Cerqueira Bomfim; Magda Lahorgue Nunes; Graciane Radaelli; Katherine Bianchini Esper; Aline Kotoski; Willian Pripp; Felipe Kalil Neto; Luciana Schermann Azambuja; Nathalia Mathias; Danielle Irigoyen da Costa; Mirna Wetters Portuguez; Jaderson Costa da Costa; Augusto Buchweitz

    Objectives: We propose and evaluate a system for assessing severity of ZikV-related microcephaly brain abnormalities called RaRe (Radiological Reading score). The system is a combination of neuroradiologist evaluation scores; we also propose and evaluate its semi-automated version, which is generated from MRI indices. Design: We carried out a cross-sectional study with retrospective data collection

    更新日期:2020-07-13
  • Clustering fibromyalgia patients: A combination of psychosocial and somatic factors leads to resilient coping in a subgroup of fibromyalgia patients
    medRxiv. Neurol. Pub Date : 2020-07-10
    Alexandra Braun; Dimitar Evdokimov; Johanna Frank; Paul Pauli; Nurcan Üceyler; Claudia Sommer

    Background: Coping strategies and their efficacy vary greatly in patients suffering from fibromyalgia syndrome (FMS). Objective: We aimed to identify somatic and psychosocial factors that might contribute to different coping strategies and resilience levels in FMS. Subjects and methods: Standardized questionnaires were used to assess coping, pain, and psychological variables in a cohort of 156 FMS

    更新日期:2020-07-10
  • Advanced imaging to improve remission rates in patients undergoing transsphenoidal surgery for Cushings disease: A protocol for systematic review and meta-analysis
    medRxiv. Neurol. Pub Date : 2020-07-09
    Chan Hee Koh; Danyal Zaman Khan; Hugo Layard Horsfall; Ahmad Ali; Ronneil Digpal; Jane Evanson; Hani J Marcus; Marta Korbonits

    INTRODUCTION: Cushings disease is a condition of hypercortisolaemia caused by a functional adrenocorticotropic hormone secreting pituitary adenoma. Surgical management is the first line of treatment for Cushings disease, but remains challenging in some cases. Various imaging modalities have been tried in an attempt to improve surgical remission rates. However, the sizes and certainties of any effect

    更新日期:2020-07-09
  • Two Separate, Large Cohorts Reveal Modifiers of Age-Related Change in Visual Reaction Time Performance
    medRxiv. Neurol. Pub Date : 2020-07-08
    Joshua S Talboom; Matt D De Both; Marcus A Naymic; Annie M Schmidt; Candace R Lewis; Wayne Mathew Jepsen; Asta K Haberg; Tatjana Rundek; Bonnie E Levin; Siobhan M Hoscheidt; Yvette Bolla; Roberta Diaz Brinton; Nicholas J Schork; Meredith Hay; Carol A. Barnes; Elizabeth Glisky; Lee Ryan; Matt Huentelman

    To help identify factors influencing age-related cognitive decline and disease, a web-based simple visual reaction time (RT and svRT respectively, index of processing speed) and paired-associate learning (PAL, indexing of verbal episodic memory) task were implemented. Test results were combined with 22 survey questions. An analysis of RT and svTR data from the MindCrowd (n=75,666) cohort revealed education

    更新日期:2020-07-08
  • Can antiepileptic drug efficacy be studied from electronic health records? A review of current approaches
    medRxiv. Neurol. Pub Date : 2020-07-07
    Barbara McElwee Decker; Chloe Electra Hill; Steven N Baldassano; Pouya Khankhanian

    As automated data extraction and natural language processing (NLP) are rapidly evolving, applicability to harness large data to improve healthcare delivery is garnering great interest. Assessing antiepileptic drug (AED) efficacy remains a barrier to improving epilepsy care. In this review, we examined automatic electronic health record (EHR) extraction methodologies pertinent to epilepsy examining

    更新日期:2020-07-07
  • Adverse Events in Surgical Neurology: The Novel Therapy-Disability-Neurology (TDN) Grade
    medRxiv. Neurol. Pub Date : 2020-07-07
    Alexis Paul Romain Terrapon; Costanza Maria Zattra; Stefanos Voglis; Julia Velz; Flavio Vasella; Kevin Akeret; Ulrike Held; Silvia Schiavolin; Oliver Bozinov; Paolo Ferroli; Morgan Broggi; Johannes Sarnthein; Luca Regli; Marian Christoph Neidert

    Background The most widely used classifications of adverse events (AE) in surgical neurology assign a grade to AE that depends on the therapy used to treat them or on new neurologic deficits. Both concepts have substantial shortcomings in grading AE severity. We present a novel multidimensional approach to this challenge and aim at validating the new grading system. Methods The new Therapy-Disability-Neurology

    更新日期:2020-07-07
  • High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms
    medRxiv. Neurol. Pub Date : 2020-07-06
    Christiana Franke; Caroline Ferse; Jakob Kreye; Momsen Reincke; Elisa Sanchez-Sendin; Andrea Rocco; Mirja Steinbrenner; Stefan Angermair; Sascha Treskatsch; Daniel Zickler; Kai-Uwe Eckardt; Rick Dersch; Jonas Hosp; Heinrich J. Audebert; Matthias Endres; Christoph J. Ploner; Harald Pruess

    COVID-19 intensive care patients occasionally develop neurological symptoms. The absence of SARS-CoV-2 in most cerebrospinal fluid (CSF) samples suggests the involvement of further mechanisms including autoimmunity. We therefore determined whether anti-neuronal or anti-glial autoantibodies are present in eleven consecutive severely ill COVID-19 patients presenting with unexplained neurological symptoms

    更新日期:2020-07-07
  • Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma
    medRxiv. Neurol. Pub Date : 2020-07-05
    Dieter Henrik Heiland; Robin Ohle; Debora Cipriani; Pamela Franco; Daniel Delev; Simon P. Behriger; Elias Kellner; Gergana Petrova; Nicolas Neidert; Irina Mader; Mateo Farina Nunez; Horst Urbach; Roman Sankowski; Juergen Beck; Oliver Schnell

    Background: Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10-20 years. However, during the course of the disease, multiple recurrences occur and

    更新日期:2020-07-05
  • Maternal biomarkers for early prediction of the neural tube defects pregnancies
    medRxiv. Neurol. Pub Date : 2020-07-05
    Upendra Yadav; Pradeep Kumar; Vandana Rai

    Neural tube defects (NTD) are the most common congenital birth defects. The reason for the NTD cause is still not completely known, but it is believed that some genetic and environmental factors might play a role in its etiology. Among the genetic factors the polymorphism in the folate gene pathway is crucial. Numerous studies have suggested the possible role of maternal higher plasma concentration

    更新日期:2020-07-05
  • Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade
    medRxiv. Neurol. Pub Date : 2020-07-05
    Katarzyna Winek; Sebastian Lobentanzer; Bettina Nadorp; Serafima Dubnov; Claudia Dames; Gilli Moshitzky; Benjamin Hotter; Christian Meisel; David S Greenberg; Sagiv Shifman; Jochen Klein; Shani Shenhar-Tsarfaty; Andreas Meisel; Hermona Soreq

    Stroke is a leading cause of death and disability. Recovery depends on balance between inflammatory response and immune suppression, which can be CNS-protective but may worsen prognosis by increasing patients' susceptibility to infections. Peripheral cholinergic blockade of immune reactions fine-tunes this immune response, but its molecular regulators are unknown. Therefore, we sought small RNA balancers

    更新日期:2020-07-05
  • Convolutional neural networks on eye tracking trajectories in patients with spatial neglect
    medRxiv. Neurol. Pub Date : 2020-07-05
    Benedetta Franceschiello; Alexia Bourgeois; Astrid Minier; Micah M. Murray; Pierre Pouget; Paolo Bartolomeo; Fabio Anselmi

    Eye-movement trajectories are rich behavioral data, providing a window onto how the brain processes information. Analyses of these trajectories can be automated and benefit from machine learning algorithms. Among those, deep learning has recently proven very successful, setting new state-of-art results in many computer vision applications, including medical diagnosis systems. In this paper, we address

    更新日期:2020-07-05
  • Impact of Viz LVO on Time-to-Treatment and Clinical Outcomes in Large Vessel Occlusion Stroke Patients Presenting to Primary Stroke Centers
    medRxiv. Neurol. Pub Date : 2020-07-05
    Jacob R Morey; Emily Fiano; Kurt A Yaeger; Xiangnan Zhang; Johanna T Fifi

    Introduction: Randomized controlled trials have demonstrated the importance of time-to-treatment on clinical outcomes in large vessel occlusion (LVO) stroke. Delays in interventional radiology (INR) consultation are associated with a significant delay in overall time to endovascular treatment (EVT). Delays in EVT are particularly prevalent in Primary Stroke Centers (PSC), hospitals without thrombectomy

    更新日期:2020-07-05
  • Determinants of quality of life in Latin American people with drug-resistant epilepsy: A cross-sectional, correlational study
    medRxiv. Neurol. Pub Date : 2020-07-04
    Marco Antonio Diaz-Torres; Edith Giselle Buzo-Jarquin; Aime Carolina Rodriguez-Martinez; Diana Laura de Leon-Altamira; Gerardo Padilla-Rivas; Sergio Andres Castillo-Torres; Jaime E. G. Olivas-Reyes; Miguel Cisneros-Franco

    One third of people with epilepsy (PWE) continue to have seizures despite adequate antiepileptic drug treatment. This condition, known as drug-resistant epilepsy (DRE) significantly impairs their social, family and work environment. The aims of this study were to assess the quality of life (QoL) in PWE with DRE and to investigate which factors are associated with a better QoL. This was a cross-sectional

    更新日期:2020-07-05
  • APOE4 Copy Number-Dependent Proteomic changes in the Cerebrospinal Fluid
    medRxiv. Neurol. Pub Date : 2020-07-02
    Miles Berger; Mary Cooter; Alexander S. Roesler; Stacey Chung; John Park; Jennifer L. Modliszeski; Keith W. VanDusen; Will Thompson; Arthur Moseley; Michael J. Devinney; Shayan Smani; Ashley Hall; Victor Cai; Jeffrey N. Browndyke; Michael W. Lutz; David L. Corcoran; Alzheimer's Disease Neuroimaging Initiative

    Background: APOE4 has been hypothesized to increase Alzheimer's disease risk by increasing neuroinflammation, though the specific neuroinflammatory pathways involved are unclear. Objectives: To characterize CSF proteomic changes as a function of APOE4 copy number. Methods: We analyzed targeted proteomic data obtained on ADNI CSF samples using a linear regression model adjusting for age, sex, and APOE4

    更新日期:2020-07-02
  • Discriminating cognitive performance using biomarkers extracted from linear and nonlinear analysis of EEG signals by machine learning
    medRxiv. Neurol. Pub Date : 2020-07-02
    Shivabalan K R; BROTOTO DEB; Shivam Goel; Sivanesan S

    Nonlinear dynamics and chaos theory are being widely used nowadays in neuroscience to characterize complex systems within which the change of the output isn't proportional to the change of the input. Nonlinear systems compared to linear systems, often appear chaotic, unpredictable, or counterintuitive, and yet their behaviour isn't random. The importance of the time series analysis, which exhibits

    更新日期:2020-07-02
  • Resting-state fMRI Connectivity between Semantic and Phonologic Regions of Interest May Inform Language Targets in Aphasia
    medRxiv. Neurol. Pub Date : 2020-07-01
    Amy E. Ramage; Semra Aytur; Kirrie J. Ballard

    Purpose: Brain imaging has provided puzzle pieces in the understanding of language. In neurologically healthy populations, structure of certain brain regions is associated with particular language functions (e.g., semantics, phonology). In studies on focal brain damage, certain brain regions or connections are considered sufficient or necessary for a given language function. However, few of these account

    更新日期:2020-07-01
  • Developing and Validating a New Web-Based Tapping Test for Measuring Distal Bradykinesia in Parkinson's Disease
    medRxiv. Neurol. Pub Date : 2020-07-01
    Noreen Akram; Haoxuan Li; Aaron Ben-Joseph; Caroline Budu; David Gallagher; Jonathan P Bestwick; Alastair J Noyce; Cristina Simonet

    Background: Disability in Parkinson′s disease (PD) is measured by standardised scales including the MDS-UPDRS, which are subject to high inter and intra-rater variability and fail to capture subtle motor impairment. The BRadykinesia Akinesia INcoordination (BRAIN) test is a previously validated keyboard tapping test, evaluating proximal upper-limb motor impairment. Here, a new Distal Bradykinesia Tapping

    更新日期:2020-07-01
  • Impact of COVID-19 related lockdown on cognition and emotion: A pilot study
    medRxiv. Neurol. Pub Date : 2020-07-01
    Durjoy Lahiri; Souvik Dubey; Alfredo Ardila

    COVID-19 pandemic has posed an unprecedented challenge in front of the world contributed mostly by social distancing and lockdown. Among several other effects this pandemic has wreaked havoc on the psychology and cognition of people across the globe. In this paper we attempted to find out the impact of lockdown and social isolation on the cognition and emotion of young healthy adults with high education

    更新日期:2020-07-01
  • Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study
    medRxiv. Neurol. Pub Date : 2020-06-29
    Lars B Hindenes; Asta K Håberg; Liv Hege Johnsen; Ellisiv B Mathiesen; David Robben; Torgil R Vangberg

    The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibit considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40 - 87 years)

    更新日期:2020-06-30
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