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  • Dynamic functional connectivity analysis reveals transiently increased segregation in patients with severe stroke
    medRxiv. Neurol. Pub Date : 2020-06-03
    Anna K Bonkhoff; Markus D Schirmer; Martin Bretzner; Mark Etherton; Kathleen Donahue; Carissa Tuozzo; Marco Nardin; Anne K Giese; Ona Wu; Vince Calhoun; Christian Grefkes; Natalia S Rost

    Background and Purpose To explore the whole-brain dynamic functional network connectivity patterns in acute ischemic stroke (AIS) patients and their relation to stroke severity in the short and long term. Methods We investigated large-scale dynamic functional network connectivity of 41 AIS patients two to five days after symptom onset. Re-occurring dynamic connectivity configurations were obtained

    更新日期:2020-06-03
  • Validation of Remote Testing using BrainCheck, a Computerized Neurocognitive Test
    medRxiv. Neurol. Pub Date : 2020-06-03
    Siao Ye; Bin Huang; Kevin Sun; Huy Phi; Reza Hosseini Ghomi

    Remote computerized neurocognitive testing (CNT) is a promising solution to have these assessments more accessible to a population facing a global pandemic and increased aging. BrainCheck (BC) is a CNT software available on iPhone, iPad, and computer browser, designed to fit the need for remote testing. Consistent measures across these varying platforms are necessary to ensure users have consistent

    更新日期:2020-06-03
  • Cerebrospinal fluid A beta 1-40 peptides increase in Alzheimer's disease and are highly correlated with phospho-tau in control individuals
    medRxiv. Neurol. Pub Date : 2020-06-02
    Sylvain Lehmann; Julien Dumurgier; Xavier Ayrignac; Cecilia Marelli; Daniel Alcolea; Juan Fortea-Ormaechea; Eric Thouvenot; Constance Delaby; Christophe Hirtz; Jerome Vialaret; Nelly Ginestet; Elodie Bouaziz-Amar; Jean-Louis Laplanche; Pierre Labauge; Claire Paquet; Alberto Lleo; Audrey Gabelle; ADNI for the Alzheimer's Disease Neuroimaging Initiative

    Background: Amyloid pathology, which is one of the characteristics of Alzheimer's disease (AD), results from altered metabolism of the beta-amyloid peptide (Aβ) in terms of synthesis, clearance or aggregation. A decrease in cerebrospinal fluid (CSF) level Aβ1-42 is evident in AD, and the CSF ratio Aβ40 /Aβ40 has recently been identified as one of the most reliable diagnostic biomarkers of amyloid pathology

    更新日期:2020-06-02
  • The Mini Linguistic State Examination (MLSE): a brief but accurate assessment tool for classifying Primary Progressive Aphasias
    medRxiv. Neurol. Pub Date : 2020-06-02
    Nikil Patel; Katie A Peterson; Ruth Ingram; Ian Storey; Stefano F Cappa; Eleonora Catricala; Karalyn E Patterson; Matthew A Lambon Ralph; James B Rowe; Peter Garrard

    Background: This paper introduces a new clinical test, the Mini Linguistic State Examination (MLSE), as a short assessment for screening and classification of the different manifestations of primary progressive aphasia (PPA). Differentiation and monitoring of PPA variants are vital for management, planning and development of new treatments. The MLSE is designed to improve the uniformity of testing

    更新日期:2020-06-02
  • Syncope at SARS-CoV-2 onset due to impaired baroreflex response
    medRxiv. Neurol. Pub Date : 2020-06-02
    Ciro Canetta; Silvia Accordino; Elisabetta Buscarini; Gianpaolo Benelli; Giuseppe La Piana; Alessandro Scartabellati; Giovanni Vigano'; Roberto Assandri; Alberto Astengo; Chiara Benzoni; Gianfranco Gaudiano; Daniele Cazzato; Sebastiano Davide Rossi; Susanna Usai; Irene Tramacere; Giuseppe Lauria

    We describe clinical and laboratory findings in 35 consecutive patients tested positive for SARS-CoV-2 by reverse transcriptase-polymerase chain reaction on nasopharyngeal swab that presented one or multiple syncopal events at disease onset. Neurological examination and electrocardiographic findings were normal. Chest computed tomography showed findings consistent with interstitial pneumonia. Arterial

    更新日期:2020-06-02
  • Amyloid-β PET and CSF in an autopsy confirmed cohort
    medRxiv. Neurol. Pub Date : 2020-06-02
    Juhan Reimand; Baayla D.C. Boon; Lyduine E. Collij; Charlotte E. Teunissen; Annemieke J.M. Rozemuller; Bart N.M. van Berckel; Philip Scheltens; Rik Ossenkoppele; Femke Bouwman

    Objective: Accumulation of amyloid-β is among the earliest changes in Alzheimers disease (AD). Amyloid-β positron emission tomography (PET) and Aβ42 in cerebrospinal fluid (CSF) both assess amyloid-β pathology in-vivo, but 10-20% of cases show discordant (CSF+/PET- or CSF-/PET+) results. The neuropathological correspondence with amyloid-β CSF/PET discordance is unknown. Methods: We included 21 patients

    更新日期:2020-06-02
  • Going off the rails: Impaired coherence in the speech of patients with semantic control deficits
    medRxiv. Neurol. Pub Date : 2020-06-02
    Paul Hoffman; Lucy Cogdell-Brooke; Hannah Thompson

    The ability to speak coherently, maintaining focus on the topic at hand, is critical for effective communication and is commonly impaired following brain damage. Recent data suggests that executive processes that regulate access to semantic knowledge (i.e., semantic control) are critical for maintaining coherence during speech. To test this hypothesis, we assessed speech coherence in a case-series

    更新日期:2020-06-02
  • Left frontal white matter atrophy links to timing mechanisms relevant to apraxia of speech
    medRxiv. Neurol. Pub Date : 2020-06-01
    Rose Bruffaerts; Jolien Schaeverbeke; Manon Grube; Silvy Gabel; An-Sofie De Weer; Eva Dries; Karen Van Bouwel; Timothy Griffiths; Stefan Sunaert; Rik Vandenberghe

    Objective In apraxia of speech (AOS), we observed impaired perceptual timing abilities, which lead us to propose a shared mechanism of impaired perceptual timing underlying impaired rhythm discrimination (perceptual processing) and AOS (motor speech output). Given that considerable white matter damage is observed in these patients, we investigate whether white matter changes are related to impaired

    更新日期:2020-06-01
  • Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients
    medRxiv. Neurol. Pub Date : 2020-06-01
    Benjamin I Ferleger; Brady Houston; Margaret C Thompson; Sarah S Cooper; Kazi Sabrina Sonnet; Andrew L Ko; Jeffrey A Herron; Howard J Chizeck

    Objective: Deep brain stimulation (DBS) is a safe and established treatment for essential tremor (ET) and several other movement disorders. One approach to improving DBS therapy is adaptive DBS (aDBS), in which stimulation parameters are modulated in real time based on biofeedback from either external or implanted sensors. Previously tested systems have fallen short of translational applicability due

    更新日期:2020-06-01
  • Structural neuroplastic responses preserve functional connectivity and neurobehavioural outcomes in children born without corpus callosum
    medRxiv. Neurol. Pub Date : 2020-05-30
    Vanessa Siffredi; Maria G Preti; Valeria Kebets; Silvia Obertino; Richard J Leventer; Alissandra McIlroy; Amanda G Wood; Vicki Anderson; Megan Mary Spencer-Smith; Dimitri Van De Ville

    Background: The corpus callosum is the largest white matter pathway in the brain connecting the left and the right hemispheres. Developmental absence of the corpus callosum is a model disease for exploring disrupted connectivity and in turn understanding plasticity of the human brain, with atypically developing structure and function resulting in a highly heterogeneous clinical and cognitive profile

    更新日期:2020-05-30
  • Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations
    medRxiv. Neurol. Pub Date : 2020-05-30
    Uladzislau Rudakou; Eric Yu; Lynne M Krohn; Jennifer A Ruskey; Yves Dauvilliers; Dan Spiegelman; Lior Greenbaum; Stanley Fahn; Cheryl H Waters; Nicolas Dupré; Guy Rouleau; Sharon Hassin-Baer; Edward A Fon; Roy N Alcalay; Ziv Gan-Or

    Genome-wide association studies (GWAS) have identified numerous loci associated with Parkinson's disease. The specific genes and variants that drive the associations within the vast majority of these loci are unknown. We aimed to perform a comprehensive analysis of selected genes to determine the potential role of rare and common genetic variants within these loci. We fully sequenced 32 genes from

    更新日期:2020-05-30
  • Objective dystonia prediction with MRI after neonatal hypoxic-ischemic encephalopathy
    medRxiv. Neurol. Pub Date : 2020-05-29
    Keerthana Chintalapati; Hanyang Miao; Amit Mathur; Jeff Neil; Bhooma Rajagopalan Aravamuthan

    Aim: To determine an objective and clinically-feasible method to predict dystonia in cerebral palsy (CP) using magnetic resonance imaging (MRI) following neonatal hypoxic-ischemic encephalopathy (HIE). Methods: In this retrospective case-control study, we examined brain MRIs in neonates at age 4-5 days who underwent therapeutic hypothermia for HIE at a single tertiary care center. The lower average

    更新日期:2020-05-29
  • Extensive Healthy Donor Age/Gender Adjustments and Propensity Score Matching Reveal Physiology of Multiple Sclerosis through Immunophenotyping
    medRxiv. Neurol. Pub Date : 2020-05-29
    Paavali Hannikainen; Peter Kosa; Christopher Barbour; Bibiana Bielekova

    Quantifying cell subpopulations in biological fluids aids in diagnosis and understanding of the mechanisms of injury. Although much has been learned from cerebrospinal fluid (CSF) flow cytometry in neuroimmunological disorders such as multiple sclerosis (MS), previous studies did not contain enough healthy donors (HD) to derive age- and gender-related normative data and sufficient heterogeneity of

    更新日期:2020-05-29
  • COVID-19 in Multiple Sclerosis Patients and Risk Factors for Severe Infection
    medRxiv. Neurol. Pub Date : 2020-05-29
    Farhan Chaudhry; Helena Bulka; Anirudha S Rathnam; Omar M Said; Jia Lin; Holly Lorigan; Evanthia Bernitsas; Jacob Rube; Steven J Korzeniewski; Anza B Memon; Phillip D Levy; Adil Javed; Robert Lisak; Mirela Cerghet

    Importance: Multiple sclerosis patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, no study has identified clinical characteristics of multiple sclerosis associated with worse COVID-19 outcomes. Objective: To evaluate the clinical characteristics of multiple sclerosis, including staging, degree of disability

    更新日期:2020-05-29
  • Etiology and Outcomes of Acute Flaccid Paralysis in Adults: A Study in Tertiary Care Center.
    medRxiv. Neurol. Pub Date : 2020-05-29
    Mohit Gupta; Sarav Gunjit Singh Daid

    INTRODUCTION: The World Health Organization defines acute flaccid paralysis syndrome as rapid onset of weakness of an individual's extremities, often including weakness of the muscles of respiration and swallowing, progressing to maximum severity within 1 to 10 days. We carried out this observational study in a tertiary care center in North India with the aim of determining the etiology and outcome

    更新日期:2020-05-29
  • Modulation of premotor cortex response to sequence motor learning during escitalopram-intake
    medRxiv. Neurol. Pub Date : 2020-05-29
    Eoin N Molloy; Karsten Mueller; Nathalie Beinhoelzl; Maria Bloechl; Fabian Piecha; Andre Pampel; Christopher Steele; Ulrike Scharrer; Gergana Zheleva; Ralf Regenthal; Bernard Sehm; Vadim Nikulin; Harald Moeller; Arno Villringer; Julia Sacher

    The contribution of selective serotonin reuptake inhibitors (SSRIs) to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we use functional magnetic resonance imaging (fMRI) in a double-blind, randomized controlled study powered

    更新日期:2020-05-29
  • Continuous Electroencephalography (cEEG) Characteristics and Acute Symptomatic Seizures in COVID-19 Patients
    medRxiv. Neurol. Pub Date : 2020-05-28
    Shreya Louis; Andrew Dhawan; Christopher Newey; Dileep Nair; Lara Jehi; Stephen Hantus; Vineet Punia

    Background: Neurological manifestations of COVID-19 have only recently been described, with a paucity of literature reporting the potential relationship between COVID-19 and acute symptomatic seizures. Two prior studies found no clinical or electrographic seizures in their cohorts of COVID-19 patients with altered mental status (AMS) and clinical seizure-like events (SLEs). Methods: In this retrospective

    更新日期:2020-05-28
  • Combining two large clinical cohorts (AIBL and ADNI) to identify multiple lipid metabolic pathways in prevalent and incident Alzheimer's disease.
    medRxiv. Neurol. Pub Date : 2020-05-28
    Kevin Huynh; Florence Lim; Corey Giles; Kaushala S Jayawardana; Agus Salim; Natalie A Mellett; Alexander Smith; Gavriel Olshansky; Brian G Drew; Pratishtha Chatterjee; Ian Martins; Simon M Laws; Ashley I Bush; Christopher C Rowe; Victor L Villemagne; David Ames; Colin L Masters; Matthias Arnold; Kwangsik Nho; Andrew J Saykin; Rebecca Baillie; Xianlin Han; Rima Kaddurah-Daouk; Ralph N Martins; Peter

    Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising of many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 lipid species across 32 lipid (sub)classes) allows for detailed isomeric and isobaric

    更新日期:2020-05-28
  • Human CA1 and subiculum activity forecast stroke chronicity
    medRxiv. Neurol. Pub Date : 2020-05-27
    Diogo Santos-Pata; Belen Rubio Ballester; Riccardo Zucca; Carlos Stefano Filho; Sara Regina Almeida; Li Li Min; Gabriela Castellano; Paul FMJ Verschure

    Following a stroke, the brain undergoes a process of neuronal reorganization to compensate for structural damage and cope with functionality loss. Increases in stroke-induced neurogenesis rates in the dentate gyrus and neural migration from the hippocampus towards the affected site have been observed, suggesting that the hippocampus is involved in functionality gains and neural reorganization. Despite

    更新日期:2020-05-27
  • Characteristics of Ischemic Stroke in COVID-19: A Need for Early Detection and Management
    medRxiv. Neurol. Pub Date : 2020-05-26
    Dinesh V. Jillella; Nicholas J. Janocko; Fadi Nahab; Karima Benameur; James G. Greene; Wendy L. Wright; Mahmoud Obideen; Srikant Rangaraju

    Objective: In the setting of the Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke has been suggested. We aimed to describe the characteristics of patients who were admitted with COVID-19 and had an acute ischemic stroke (AIS). Methods: This is a case series of PCR-confirmed COVID-19 patients with ischemic stroke admitted to

    更新日期:2020-05-26
  • COVID-19 impact on consecutive neurological patients admitted to the emergency department
    medRxiv. Neurol. Pub Date : 2020-05-26
    Andrea Pilotto; Alberto Benussi; Ilenia Libri; Stefano Masciocchi; Loris Poli; Enrico Premi; Antonella Alberici; Enrico Baldelli; Sonia Bonacina; Laura Brambilla; Matteo Benini; Salvatore Caratozzolo; Matteo Cortinovis; Angelo Costa; Stefano Cotti Piccinelli; Elisabetta Cottini; Viviana Cristillo; Ilenia Delrio; Massimiliano Filosto; Massimo Gamba; Stefano Gazzina; Nicola Gilberti; Stefano Gipponi;

    Abstract Objective: Aim of this study was to analyse the impact of COVID-19 on clinical and laboratory findings and outcome of neurological patients consecutively admitted to the emergency department (ED) of a tertiary hub center. Methods: All adult patients consecutively admitted to the ED for neurological manifestations from February 20 th through April 30 th 2020 at Spedali Civili of Brescia entered

    更新日期:2020-05-26
  • Radiofrequency Monitoring of Intracranial Hemorrhage in the Neurological Intensive Care Unit: A Pilot Trial of the SENSE Device
    medRxiv. Neurol. Pub Date : 2020-05-26
    Joseph J Korfhagen; George J Shaw; Matthew L. Flaherty; Opeolu Adeoye; William A. Knight

    Intracerebral hemorrhage (ICH) is a devastating form of stroke, with substantial mortality and morbidity. Hemorrhage expansion (HE) occurs in ∼40% of patients and portends worse neurologic outcome and mortality. Currently, ICH patients are admitted to the intensive care unit (ICU) and monitored for HE with neurologic exam and neuroimaging. By the time a change is detected, it may be too late to mitigate

    更新日期:2020-05-26
  • COVID-19: A Chronological Review of the Neurological Repercussions - What do We Know by May, 2020?
    medRxiv. Neurol. Pub Date : 2020-05-26
    Paulo Afonso Mei; Laura Loeb

    Abstract Introduction: Despite the new SARS-CoV-2 (COVID-19) be the seventh of the coronavirus family viruses known to cause human disease, little is known about potential symptoms and syndromes secondary to the compromise of the central and peripheral nervous systems. We reviewed neurological manifestations due to the new coronavirus, thus far published in the literature, as well as guidelines issued

    更新日期:2020-05-26
  • Sleep in severe disorders of consciousness: 24-h behavioral and polysomnographic recording
    medRxiv. Neurol. Pub Date : 2020-05-26
    Isabella Mertel; Yuri G. Pavlov; Christine Barner; Friedemann Müller; Susanne Diekelmann; Boris Kotchoubey

    Objectives: To quantify, on a reliable evaluation basis, the distribution of behavioral and neurophysiological sleep patterns in Disorders of Consciousness (DOC) over a 24h period while controlling for environmental factors (by recruiting a group of conscious tetraplegic patients who resided in the same hospital). Methods: We evaluated the distribution of sleep and wakefulness by means of polysomnography

    更新日期:2020-05-26
  • Neuroinflammation predicts disease progression in progressive supranuclear palsy
    medRxiv. Neurol. Pub Date : 2020-05-26
    Maura Malpetti; Luca Passamonti; P. Simon Jones; Duncan Street; Timothy Rittman; Tim D. Fryer; Young T. Hong; Patricia Vasquez-Rodriguez; William Richard Bevan-Jones; Franklin I. Aigbirhio; John T. O'Brien; James B Rowe

    Objective: In addition to tau pathology and neuronal loss, neuroinflammation occurs in progressive supranuclear palsy (PSP). We test the hypotheses that baseline in vivo assessments of regional neuroinflammation ([11C]PK11195 PET), tau pathology ([18F]AV-1451 PET), and atrophy (structural MRI) predict disease progression. Methods: Seventeen patients with PSP-Richardson′s syndrome underwent a baseline

    更新日期:2020-05-26
  • Ataxia as a presenting manifestation of COVID -19: Report of a single case
    medRxiv. Neurol. Pub Date : 2020-05-26
    Debaleena Mukherjee; Peyalee Sarkar; Souvik Dubey; Biman Kanti Ray; Alak Pandit; Durjoy Lahiri

    Even though various neurological presentations of COVID-19 have surfaced up, ataxia as a presenting feature has rarely been reported so far. We hereby describe a confirmed case of SARS-CoV-2 infection which not only presented with ataxia but also had delayed onset of typical respiratory features. This case represents an atypical manifestation of COVID-19.

    更新日期:2020-05-26
  • Mild Behavioral Impairment and Subjective Cognitive Decline predict Mild Cognitive Impairment
    medRxiv. Neurol. Pub Date : 2020-05-25
    Zahinoor Ismail; Alexander McGirr; Sascha Gill; Sophie Hu; Nils D Forkert; Eric E Smith

    Objective: Better methods for detecting preclinical neuropathological change are required for prevention of dementia. Mild behavioral impairment (MBI) and subjective cognitive decline (SCD) can represent neurobehavioral and neurocognitive axes of early stage neurodegenerative processes, which are represented in Stage 2 of the NIA-AA Alzheimers disease research framework. Both MBI and SCD may offer

    更新日期:2020-05-25
  • Effects of Age and Knee Osteoarthritis on the Modular Control of Walking: A Pilot Study
    medRxiv. Neurol. Pub Date : 2020-05-24
    Sarah Anne Roelker; Rebekah R Koehn; Elena J Caruthers; Laura C Schmitt; Ajit MW Chaudhari; Robert A Siston

    Older adults and individuals with knee osteoarthritis (KOA) often exhibit reduced locomotor function and altered muscle activity. Identifying age- and KOA-related changes to the modular control of gait may provide insight into the neurological mechanisms underlying reduced walking performance in these populations. The purpose of this pilot study was to determine if the modular control of walking differs

    更新日期:2020-05-24
  • A super-series of extracellular miRNA in cerebrospinal fluid reveals broad patterns associated with neurologic disease
    medRxiv. Neurol. Pub Date : 2020-05-23
    Andrew Dhawan

    Extracellular non-coding RNA are emerging biomarkers across diseases, as they may represent the functional state of the cells of origin, and have been robustly detected and associated with disease in many biofluids, but not yet at a large scale in cerebrospinal fluid (CSF). While there have been extracellular non-coding RNA (exmiRNA) identified in small associative studies involving the CSF and patients

    更新日期:2020-05-23
  • Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
    medRxiv. Neurol. Pub Date : 2020-05-22
    Christopher Barbour; Peter Kosa; Mihael Varosanec; Mark Greenwood; Bibiana Bielekova

    The inability to measure putative pathogenic processes in the central nervous system (CNS) of living subjects precludes the determination of their temporal distribution, intra-individual heterogeneity, and their ability to predict disease course. Using multiple sclerosis (MS) as an example of a complex neurological disorder, we sought to determine if cerebrospinal fluid (CSF) biomarkers can be aggregated

    更新日期:2020-05-22
  • Ischemic Heart Disease and Cognitive Prognosis in the First Year after Stroke
    medRxiv. Neurol. Pub Date : 2020-05-22
    Michael J O'Sullivan; Paul Wright

    Importance: Cognitive impairment is the greatest single source of unmet need identified by stroke survivors. Knowledge of the factors that influence cognitive prognosis will lead to better preventive and rehabilitation strategies. Objective: To identify the factors that influence general cognitive function, memory and executive function in the first year after ischemic stroke. Design: Single centre

    更新日期:2020-05-22
  • Biomarkers of Parkinson's Disease: Screening Vital Signs and Routine Blood Tests
    medRxiv. Neurol. Pub Date : 2020-05-22
    Hirotaka IWAKI; Hampton L. Leonard; Sara Bandres Ciga; Cornelis Blauwendraat; Mary B. Makarious; Sonja W. Scholz; Noriko Nishikawa; Faraz Faghri; Mark Frasier; J. Raphael Gibbs; Andrew B. Singleton; Mike A. Nalls; Dena G. Hernandez

    BACKGROUND: There is a need for reliable, objective, and easily accessible biomarkers for Parkinson's disease. OBJECTIVES: The purpose of this study was to screen biomarkers from vital signs and routine blood tests. METHODS: Longitudinal data of up to 7 years of vital signs and routine blood tests from 418 patients with Parkinson's disease (PD) untreated at baseline and 185 individuals without any

    更新日期:2020-05-22
  • Normal Human Brain Growth
    medRxiv. Neurol. Pub Date : 2020-05-22
    Mallory R Peterson; Venkateswararao Cherukuri; Joseph N Paulson; Paddy Ssentongo; Abhaya Kulkarni; Benjamin C Warf; Vishal Monga; Steven J Schiff

    Brain growth is affected by a broad range of childhood conditions that affect cognitive development, but definitive growth curves for the brain throughout childhood have not been available. We studied the brain volume growth from 1,067 normal MRI scans from 505 normal healthy children from birth through age 18. Brain volume peaked at 10-12 years of age. Males exhibited larger age-adjusted total brain

    更新日期:2020-05-22
  • A computational biomarker of juvenile myoclonic epilepsy from resting-state MEG
    medRxiv. Neurol. Pub Date : 2020-05-22
    Marinho A Lopes; Dominik Krzemiński; Khalid Hamandi; Krish D. Singh; Naoki Masuda; John R. Terry; Jiaxiang Zhang

    Objective Functional networks derived from resting-state scalp EEG from people with idiopathic (genetic) generalized epilepsy (IGE) have been shown to have an inherent higher propensity to generate seizures than those from healthy controls when assessed using the concept of brain network ictogenicity (BNI). Herein we test whether the BNI framework is applicable to resting-state MEG and whether it may

    更新日期:2020-05-22
  • Risk of Ischemic Stroke in Patients with Covid-19 versus Patients with Influenza
    medRxiv. Neurol. Pub Date : 2020-05-21
    Alexander E. Merkler; Neal S. Parikh; Saad Mir; Ajay Gupta; Hooman Kamel; Eaton Lin; Joshua Lantos; Edward J. Schenck; Parag Goyal; Samuel S. Bruce; Joshua Kahan; Kelsey N. Lansdale; Natalie M. LeMoss; Santosh B. Murthy; Philip E. Stieg; Matthew E. Fink; Costantino Iadecola; Alan Z. Segal; Thomas R. Campion; Ivan Diaz; Cenai Zhang; Babak B. Navi

    Importance: Case series without control groups suggest that Covid-19 may cause ischemic stroke, but whether Covid-19 is associated with a higher risk of ischemic stroke than would be expected from a viral respiratory infection is uncertain. Objective: To compare the rate of ischemic stroke between patients with Covid-19 and patients with influenza, a respiratory viral illness previously linked to stroke

    更新日期:2020-05-21
  • Smartphone-Based Symbol-Digit Modalities Test Reliably Measures Cognitive Function in Multiple Sclerosis Patients
    medRxiv. Neurol. Pub Date : 2020-05-20
    Linh Pham; Thomas Harris; Mihael Varosanec; Peter Kosa; Bibiana Bielekova

    Limited time for patient encounters prevents reliable evaluation of all neurological functions in routine clinical practice. Quantifying neurological disability in a patient-autonomous manner via smartphones may remedy this problem, if such tests provide reliable, disease-relevant information. We developed a smartphone version of the cognitive processing speed test, the Symbol-Digit Modalities Test

    更新日期:2020-05-20
  • High-contrast in-vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies
    medRxiv. Neurol. Pub Date : 2020-05-18
    Kenji Tagai; Maiko Ono; Manabu Kubota; Soichiro Kitamura; Keisuke Takahata; Chie Seki; Yuhei Takado; Hitoshi Shinotoh; Yasunori Sano; Kiwamu Matsuoka; Hiroyuki Takuwa; Masafumi Shimojo; Manami Takahashi; Kazunori Kawamura; Tatsuya Kikuchi; Maki Okada; Haruhiko Akiyama; Hisaomi Suzuki; Mitsumoto Onaya; Takahiro Takeda; Kimihito Arai; Nobutaka Arai; Nobuyuki Araki; Yuko Saito; Yasuyuki Kimura; Masanori

    A panel of radiochemicals has enabled in-vivo positron emission tomography (PET) of tau pathologies in Alzheimer′s disease (AD), while sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse tau deposits. In-vitro assays demonstrated the reactivity of this compound with tau pathologies

    更新日期:2020-05-18
  • Immunosurveillance of CCR6+ T-cells predicts treatment response to dimethyl-fumarate: implications for personalized treatment strategies in multiple sclerosis
    medRxiv. Neurol. Pub Date : 2020-05-18
    Constantinos Alifieris; Seunghee Kim-Schulze; Ilana Katz Sand; Patrizia Casaccia; Achilles Ntranos

    Objective: The field of multiple sclerosis (MS) has seen a tremendous expansion of treatments in the past decade. However, treatment response in individual patients can currently be determined only by waiting for breakthrough disease activity to occur. This highlights a critical need for biomarkers that can predict treatment response and stratify the risk of impeding disease activity before damage

    更新日期:2020-05-18
  • A concise, machine learning-based questionnaire that screens for insomnia and apnoea in the general population
    medRxiv. Neurol. Pub Date : 2020-05-18
    Yizhou Yu; Samantha Jackson; Erla Bjornsdottir; Charles Oulton

    Poor sleep is a major public health problem with implications for a wide range of critical health outcomes, including cardiovascular disease, obesity, mental health, and neurodegenerative disease.1,2 The most prevalent sleep disorders are insomnia and sleep apnoea. While questionnaires aimed at detecting and quantifying sleep problems have been used for years and proven to be reliable,3-6 they are

    更新日期:2020-05-18
  • COVID-19 OUTCOMES IN MS: EARLY EXPERIENCE FROM NYU MULTIPLE SCLEROSIS COMPREHENSIVE CARE CENTER
    medRxiv. Neurol. Pub Date : 2020-05-18
    Erica Parrotta; Ilya Kister; Leigh Charvet; Carrie Sammarco; Valerie Saha; R.E. Charlson; Jonathan Howard; Josef Maxwell Gutman; Malcolm Gottesman; Nada Abou-Fayssal; Robyn Wolintz; Marshall Keilson; Cristina Fernandez-Carbonell; Lauren B Krupp; Lana Zhovtis Ryerson

    Objective: Report outcomes on patients with Multiple Sclerosis (MS) and related disorders with COVID-19 illness. Methods: From March 16 to April 30th, 2020, patients with MS or related disorders at NYU Langone MS Comprehensive Care Center (MSCC) were identified with laboratory-confirmed or suspected COVID-19. The diagnosis was established using a standardized questionnaire or by a review of in-patient

    更新日期:2020-05-18
  • Investigation of somatic mutations in human brains targeting genes associated with Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-05-18
    Melissa Leija-Salazar; Alan Pittman; Katya Mokretar; Huw Morris; Anthony HV Schapira; Christos Proukakis

    Background: Somatic mutations occur in neurons but their role in synucleinopathies is unknown. Aim: We aimed to identify disease-relevant low-level somatic single nucleotide variants (SNVs) in brains from sporadic patients with synucleinopathies and a monozygotic twin carrying LRRK2 G2019S, whose penetrance could be explained by somatic variation. Methods and Results: We included different brain regions

    更新日期:2020-05-18
  • Gait variability and its progression over time in Parkinson's disease is linked to the cortical cholinergic system
    medRxiv. Neurol. Pub Date : 2020-05-16
    Kevin B Wilkins; Jordan E Parker; Helen M Bronte-Stewart

    Background: Gait impairment has a detrimental effect on the lives of individuals with Parkinson's disease (PD). Although PD is typically characterized as a dopaminergic-depletion disorder, accumulating evidence implicates cholinergic dysfunction as an additional contributor. Whereas the dopaminergic system has been widely connected to cardinal motor signs, the cortical cholinergic system plays a crucial

    更新日期:2020-05-16
  • Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder: The roles of BDNF and APOE polymorphisms
    medRxiv. Neurol. Pub Date : 2020-05-15
    Ali Jannati; Mary A Ryan; Gabrielle Block; Fae B. Kayarian; Lindsay M. Oberman; Alexander Rotenberg; Alvaro Pascual-Leone

    Objective. To assess the utility of the modulation of motor cortex (M1) excitability by continuous theta-burst stimulation (cTBS) as a physiologic biomarker for adults with autism spectrum disorder (ASD), and to evaluate the influences of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms on cTBS aftereffects. Methods. 44 neurotypical individuals (NT; age 21-65, 34 males)

    更新日期:2020-05-15
  • Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients
    medRxiv. Neurol. Pub Date : 2020-05-15
    Ketevan Berekashvili; Adam A Dmytriw; Volodomyr Vulkanov; Shashank Agarwal; Amit Khaneja; David Turkel-Parella; Jeremy Liff; Jeffrey Farkas; Thambirajah Nandakumar; Ting Zhou; Jennnifer Frontera; David E Kahn; Sun Kim; Kelly A Humbert; Matthew D Sanger; Shadi Yaghi; Aaron Lord; Karthikeyan Arcot; Ambooj Tiwari

    Objective: To describe the ischemic stroke etiopathogenesis related to COVID-19 in a cohort of NYC hospitals. Background: Extra-pulmonary involvement of COVID-19 has been reported in the hepatic, renal and hematological systems. Most neurological manifestations are non-focal but few have reported the characteristics of ischemic strokes or investigated its pathophysiology. Methods: Over the last 6 weeks

    更新日期:2020-05-15
  • In vivo PET imaging of neuroinflammation in familial frontotemporal dementia
    medRxiv. Neurol. Pub Date : 2020-05-14
    Maura Malpetti; Timothy Rittman; P Simon Jones; Thomas E Cope; Luca Passamonti; William Richard Bevan Jones; Karalyn Patterson; Tim D Fryer; Yong T Hong; Franklin I Aigbirhio; John T O'Brien; James B Rowe

    INTRODUCTION: We report in vivo patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotemporal dementia with mutations in MAPT, GRN and C9orf72 genes. METHODS: Using positron emission tomography (PET), we explored the association of the distribution of activated microglia, as measured by the radioligand [11C]PK11195, and the regional distribution of tau- or

    更新日期:2020-05-14
  • Steroid-responsive encephalitis in Covid-19 disease
    medRxiv. Neurol. Pub Date : 2020-05-14
    Andrea Pilotto; SIlvia Odolini; Stefano Masciocchi; Agnese Comelli; Irene Volonghi; Stefano Gazzina; Sara Nocivelli; Alessandro Pezzini; Emanuele Focà; Arnaldo Caruso; Matilde Leonardi; Maria Pia Pasolini; Roberto Gasparotti; Francesco Castelli; Nicholas J Ashton; Kaj Blennow; Henrik Zetterberg; Alessandro Padovani

    SARS-CoV-2 infection has the potential for targeting central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. Here we described the case of an otherwise healthy 60-year old subject with SARS-CoV-2 infection but only mild respiratory abnormalities who developed severe progressive encephalopathy associated with mild pleocytosis and hyperproteinorrachia

    更新日期:2020-05-14
  • Body mass index and carpal tunnel syndrome: a Mendelian randomization study
    medRxiv. Neurol. Pub Date : 2020-05-12
    Iyas Daghlas; Nathan Varady

    Introduction We investigated whether higher body mass index (BMI) may causally increase risk of carpal tunnel syndrome using Mendelian randomization (MR). Methods The exposure included genetic instruments comprising independent variants associated with BMI (n=322,154). Associations of these variants with CTS were obtained from a genome-wide association study conducted in UK Biobank (UKB; 12,312 cases/389

    更新日期:2020-05-12
  • Tracking multi-site seizure propagation using ictal high frequency activity
    medRxiv. Neurol. Pub Date : 2020-05-12
    Steven Tobochnik; Lisa M. Bateman; Cigdem I. Akman; Deepti Anbarasan; Carl W. Bazil; Michelle Bell; Hyunmi Choi; Neil A. Feldstein; Paul F. Kent; Danielle McBrian; Guy M. McKhann; Anil Mendiratta; Alison M. Pack; Tristan T. Sands; Sameer A. Sheth; Shraddha Srinivasan; Catherine A. Schevon

    Objective: Characterization of progressive multi-site seizure recruitment using high frequency oscillations. Methods: Ictal and interictal high frequency oscillations were identified in a series of 13 patients with 72 seizures recorded by stereotactic depth electrodes, using previously validated methods. Channels with ictal high frequency oscillations were assigned to distinct spatial clusters, and

    更新日期:2020-05-12
  • NILOTINIB IN PATIENTS WITH ADVANCED PARKINSONS DISEASE: A RANDOMIZED PHASE 2A STUDY (NILO-PD)
    medRxiv. Neurol. Pub Date : 2020-05-12
    Tanya Simuni; Brian Fiske; Kalpana Merchant; Christopher Coffey; Elizabeth Klingner; Chelsea Caspell-Garcia; David-Erick Lafontant; Helen Matthews; Richard K. Wyse; Patrik Brundin; David K. Simon; Michael Schwarzschild; David Weiner; Jaime Adams; Charles Venuto; Ted Dawson; Liana Baker; Melissa Kostrzebski; Tina Ward; Gary Rafaloff

    Background: Nilotinib, a tyrosine kinase Abelson inhibitor, exhibits neuroprotective effects in preclinical Parkinson disease (PD) models. Methods: This Phase 2A double-blind placebo-controlled study in moderate/advanced PD randomized participants 1:1:1 to placebo:150:300 mg nilotinib once daily for 6 months. The primary outcomes were safety and tolerability, the latter defined as ability to complete

    更新日期:2020-05-12
  • Effectiveness of 2nd Skull Products in Reducing Head Impact in Simulated Sports
    medRxiv. Neurol. Pub Date : 2020-05-12
    Marina Ritchie; Honghuang Lin; Rhoda Au

    Cumulative effects of repetitive head impact have been highly associated with short and long term neurological conditions. Despite high rates of head injuries, many people in the U.S. and around the world continue to participate in collision sports. As one approach to address this concern, 2nd Skull has developed supplemental protective headgears including a skull cap, scrum cap and headband that can

    更新日期:2020-05-12
  • Nonlinear Classification of EEG recordings from patients with Alzheimer's Disease using Gaussian Process Latent Variable Model
    medRxiv. Neurol. Pub Date : 2020-05-11
    Shenal R.A.S Gunawardena; Fei He; Ptolemaios Sarrigiannis; Daniel J Blackburn

    In this work, nonlinear temporal features from multi-channel EEGs are used for the classification of Alzheimer's disease patients from healthy individuals. This was achieved by temporal manifold learning using Gaussian Process Latent Variable Models (GPLVM) as a nonlinear dimensionality reduction technique. Classification of the extracted features was undertaken using a nonlinear Support Vector Machine

    更新日期:2020-05-11
  • Early postmortem brain MRI findings in COVID-19 non-survivors
    medRxiv. Neurol. Pub Date : 2020-05-08
    Tim Coolen; Valentina Lolli; Niloufar Sadeghi; Antonin Rovai; Nicola Trotta; Fabio S Taccone; Jacques Creteur; Sophie Henrard; Jean-Christophe Goffard; Olivier Dewitte; Gilles Naeije; Serge Goldman; Xavier De Tiege

    Importance: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered to have potential neuro-invasiveness that might lead to acute brain disorders or contribute to respiratory distress in patients with coronavirus disease 2019 (COVID-19). Brain magnetic resonance imaging (MRI) data in COVID-19 patients are scarce due to difficulties to obtain such examination in infected unstable

    更新日期:2020-05-08
  • WMHs AND HOMOCYSTEINE LEVELS AS CANDIDATE BIOMARKER FOR COGNITIVE IMPAIRMENT
    medRxiv. Neurol. Pub Date : 2020-05-08
    Vivek Misra; Ennapadam Srinivas Krishnamoorthy; Shruti Balaji; Jayandrakumar K; Nagarajan K

    The aim of this pilot study was to test the hypotheses that a) WMHs would be a biological marker in South Indian patients who present with either cognitive impairment, dementia or depression and b) presence of WMHs would be related to other blood biochemical markers. A significant positive correlation was present between temporal WMHs and increased homocysteine levels. A significant inverse correlation

    更新日期:2020-05-08
  • Pontine Lesions Impair Visually Guided Eye and Hand Movements
    medRxiv. Neurol. Pub Date : 2020-05-08
    Friedemann Bunjes; Hans-Peter Thier

    Although animal research and some rare human case reports suggest that lesions of the dorsal pons yield saccadic and smooth pursuit eye movement deficits, little is known about the functional topology of the human pontine nuclei (PN) and whether limb movements are similarly affected as eye movements. Saccadic as well as SP eye and pointing movements were measured in six patients with lesions in the

    更新日期:2020-05-08
  • Chronic use of a sensitized bionic hand does not remap the sense of touch
    medRxiv. Neurol. Pub Date : 2020-05-06
    Max Ortiz-Catalan; Enzo Mastinu; Sliman Bensmaia

    Electrical stimulation of tactile nerve fibers that innervated an amputated hand results in vivid sensations experienced at a specific location on the phantom hand, a phenomenon that can be leveraged to convey tactile feedback through bionic hands. Ideally, electrically evoked tactile sensations would be experienced on the appropriate part of the hand: Touch with the bionic index fingertip, for example

    更新日期:2020-05-06
  • Personalized Early Stage Alzheimer's Disease Detection: A Case Study of President Reagan's Speeches
    medRxiv. Neurol. Pub Date : 2020-05-06
    Ning Wang; Fan Luo; Vishal Peddagangireddy; K.P Subbalakshmi; Rajarathnam Chandramouli

    Alzheimer's disease (AD)-related global healthcare cost is estimated to be $1 trillion by 2050. Currently, there is no cure for this disease; however, clinical studies show that early diagnosis and intervention helps to extend the quality of life and inform technologies for personalized mental healthcare. Clinical research indicates that the onset and progression of Alzheimer's disease lead to dementia

    更新日期:2020-05-06
  • COVID-19 in Children with Brain-Based Developmental Disabilities: A Rapid Review
    medRxiv. Neurol. Pub Date : 2020-05-06
    Michele Dugas; Valerie Carnovale; Andree-Anne Poirier; Benoit Mailot; Becky Skidmore; Lena Faust; Carrie Costello; Donna Thomson; Annette Majnemer; Dan Goldowitz; Steven Miller; Annie LeBlanc

    Background. The prevalence of symptomatic COVID-19 in children remains low to date. In just a few months, COVID-19 has affected millions of people worldwide, and as of the date of this publication, the pandemic continues. Based on the current available evidence, children do not appear to be at higher risk of contracting COVID-19 than adults. However, children with neurological and neuromuscular conditions

    更新日期:2020-05-06
  • Changes in soluble CD163 indicate monocyte involvement in cognitive deficits in Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-05-06
    Sara K Nissen; Sara A Ferreira; Claudia Schulte; Kalpana Shrivastava; Dorle Hennig; Jonas Graversen; Walter Maetzler; Daniela Berg; Anne Panhelainen; Holger J Moller; Kathrin Brockmann; Marina Romero-Ramos

    Parkinson's disease is a neurodegenerative disorder with a significant immune component. Numerous studies have reported alterations on immune biomarkers in CSF and serum that associate with symptoms in PD patients. However, it is unclear, which specific immune cells are responsible for the changes in those biomarkers; since most of these cytokines or chemokines, can be produced by a variety of immune

    更新日期:2020-05-06
  • Objective extraction of movement features prompting expert-identification of dystonia in ambulatory children with cerebral palsy
    medRxiv. Neurol. Pub Date : 2020-05-06
    Bhooma Rajagopalan Aravamuthan; Keisuke Ueda; Hanyang Miao; Laura Gilbert; Sarah E Smith; Toni Pearson

    Aim: To determine the specific movement features in children with cerebral palsy (CP) that prompt expert identification of dystonia Methods: Dystonia identification in CP, particularly when co-morbid with spasticity, can be difficult. For this retrospective case-control study, we conducted a qualitative thematic analysis of consensus-building discussions between three pediatric movement disorders physicians

    更新日期:2020-05-06
  • Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta
    medRxiv. Neurol. Pub Date : 2020-05-05
    Till F. M. Andlauer; Jenny Link; Dorothea Martin; Malin Ryner; Christina Hermanrud; Verena Grummel; Michael Auer; Harald Hegen; Lilian Aly; Christiane Gasperi; Benjamin Knier; Bertram Müller-Myhsok; Poul Erik Hyldgaard Jensen; Finn Sellebjerg; Ingrid Kockum; Tomas Olsson; Marc Pallardy; Sebastian Spindeldreher; Florian Deisenhammer; Anna Fogdell-Hahn; Bernhard Hemmer; ABIRISK consortium

    Background: Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies in multiple sclerosis patients treated

    更新日期:2020-05-05
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