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  • Soluble CD163 changes indicate monocyte association with cognitive deficits in Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-10-20
    Sara K Nissen; Sara A Ferreira; Marlene C Nielsen; Claudia Schulte; Kalpana Shrivastava; Dorle Hennig; Anders Etzerodt; Jonas Graversen; Daniela Berg; Walter Maetzler; Anne Panhelainen; Holger J Moller; Kathrin Brockmann; Marina Romero-Ramos

    Background: Parkinson's disease (PD) is a neurodegenerative disorder with a significant immune component, as demonstrated by changes in immune biomarkers in patients' biofluids. However, which specific cells are responsible for those changes is unclear since most immune biomarkers can be produced by various cell types. Objectives and methods: To explore monocyte involvement in PD, we investigated the

    更新日期:2020-10-20
  • Structural and metabolic brain abnormalities in COVID-19 patients with sudden loss of smell
    medRxiv. Neurol. Pub Date : 2020-10-20
    Maxime Niesen; Nicola Trotta; Antoine Noel; Tim Coolen; Georges Fayad; Gil Leurkin-Sterk; Isabelle Delpierre; Sophie Henrard; Niloufar Sadeghi; Jean-Christophe Goffard; Serge Goldman; Xavier De Tiège

    Objectives: Sudden loss of smell is a very common symptom of coronavirus disease 19 (COVID-19). This study characterizes the structural and metabolic cerebral correlates of dysosmia in patients with COVID-19. Methods: Structural brain magnetic resonance imaging (MRI) and positron emission tomography with [18F]-fluorodeoxyglucose (FDG-PET) were prospectively acquired simultaneously on a hybrid PET-MR

    更新日期:2020-10-20
  • Concurrent comorbidities substantially alter long-term health behaviours and outcomes of headache patients
    medRxiv. Neurol. Pub Date : 2020-10-20
    Anthony Nash; Sarah Goodday; Qiang Liu; Alice Fuller; Clare Bankhead; Caleb Webber; Alejo J Nevado-Holgado; M Zameel Cader

    Objectives: To investigate factors affecting the long-term health behaviours and outcomes of headache patients and to design a risk-stratification tool. Methods: A population based observational-longitudinal cohort study using primary care electronic healthcare records from the UK Clinical Practice Research Datalink. 550,103 participants with a headache or migraine diagnosis of which 170,336 patients

    更新日期:2020-10-20
  • CGG expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy with neurological manifestations
    medRxiv. Neurol. Pub Date : 2020-10-20
    Masashi Ogasawara; Aritoshi Iida; Theerawat Kumutpongpanich; Ayami Ozaki; Yasushi Oya; Hirofumi Konishi; Akinori Nakamura; Ryuta Abe; Hiroshi Takai; Ritsuko Hanajima; Hiroshi Doi; Fumiaki Tanaka; Hisayoshi Nakamura; Ikuya Nonaka; Zhaoxia Wang; Shinichiro Hayashi; Satoru Noguchi; Ichizo Nishino

    Background Oculopharyngodistal myopathy (OPDM) is a rare hereditary muscle disease characterized by progressive distal limb weakness, ptosis, ophthalmoplegia, bulbar muscle weakness and rimmed vacuoles on muscle biopsy. Recently, CGG repeat expansions in the noncoding regions of two genes, LRP12 and GIPC1, have been reported to be causative for OPDM. Furthermore, neuronal intranuclear inclusion disease

    更新日期:2020-10-20
  • Autism Spectrum Disorder: A Systematic Review on how Diagnosis, Treatment, and Etiology have been considered in Brazil
    medRxiv. Neurol. Pub Date : 2020-10-20
    Eduardo Listik; Marcia Listik

    Autism spectrum disorder is a group of developmental disorders whose clinical characteristics include socialization impairment, language disability, and unusual behavior. This review aimed to analyze how the Brazilian community researches autism, seeking answers surrounding its treatment, etiology, and diagnosis. The search for publications was based in Elsevier's Scopus Database in June 2019 and was

    更新日期:2020-10-20
  • SARS-CoV-2 infection among patients with multiple sclerosis; A cross-sectional study
    medRxiv. Neurol. Pub Date : 2020-10-20
    Mahnaz Bayat; Alireza Fayyazpoor; Afshin Borhani Haghighi; Daniyal Salehi; Hossein Molavi Vardanjan; Maryam Poursadeghfard

    Background: Neurological disability associated with multiple sclerosis and immunosuppressive or immunomodulatory therapy which is administered for it may increases the risk of SARS-CoV-2 infection and its morbidity/mortality. Objective: In this study, we evaluated the infection rate and the severity of SARS-CoV-2 infection in patients with multiple sclerosis (MS) Methods: One thousand and three hundred

    更新日期:2020-10-20
  • Vascular Risk Factor Prevalence and Trends in Native Americans With Ischemic Stroke - A National Inpatient Sample Analysis
    medRxiv. Neurol. Pub Date : 2020-10-20
    Dinesh V Jillella; Sara Crawford; Rocio Lopez; Atif Zafar; Anne S Tang; Ken Uchino

    Introduction: Native Americans have a higher incidence and prevalence of stroke and the highest stroke-related mortality among race-ethnic groups in the United States. We aimed to analyze trends in the prevalence of vascular risk factors among Native Americans with ischemic stroke over the last two decades along with a comparison to the other race-ethnic groups. Methods: National/Nationwide Inpatient

    更新日期:2020-10-20
  • Characterising factors underlying praxis deficits in chronic left hemisphere stroke patients
    medRxiv. Neurol. Pub Date : 2020-10-20
    Elisabeth Rounis; Ajay Halai; Gloria Pizzamiglio; Matthew A Lambon Ralph

    Limb apraxia, a disorder of skilled action not consequent on primary motor or sensory deficits, has traditionally been defined according to errors patients make on neuropsychological tasks. Previous models of the disorder have failed to provide a unified account of patients deficits, due to heterogeneity in the patients and tasks used. In this study we implemented principal component analysis (PCA)

    更新日期:2020-10-20
  • AUTISM SPECTRUM DISORDER: A POSSIBLE LINK WITH CHONDROITIN SULFATE
    medRxiv. Neurol. Pub Date : 2020-10-20
    Eduardo Listik; Marcia Listik; Clarice Listik; Leny Toma

    This study aimed to determine discrepancies in the urinary glycosaminoglycan profiles of autism spectrum disorder (ASD) patients (n=9) when compared with those from healthy volunteers (HVs, n=3). The guardians and/or educators for each participant also returned a validated Autism Behavior Checklist (ABC). The urinary chondroitin sulfate (CS) concentration was 46.1% lower in the ASD group than in the

    更新日期:2020-10-20
  • Comorbid neuropathological diagnoses in early vs late-onset Alzheimer's disease
    medRxiv. Neurol. Pub Date : 2020-10-20
    Salvatore Spina; Renaud La Joie; Cathrine Petersen; Amber L Nolan; Deion Cuevas; Celica Cosme; Mackenzie Hepker; Ji-Hye Hwang; Zachary A Miller; Eric J Huang; Anna M Karydas; Harli Grant; Adam L Boxer; MariaLuisa Gorno-Tempini; Howard J Rosen; Joel H Kramer; Bruce L Miller; William W Seeley; Gil D Rabinovici; Lea T Grinberg

    Copathologies play an important role in the expression of the AD clinical phenotype and may influence treatment efficacy. Early-onset AD (EOAD), defined as manifesting before age 65, has been viewed as a relatively pure form of AD with a more homogenous neuropathological substrate. We sought to compare the frequency of common neuropathological diagnoses in a consecutive autopsy series of 96 patients

    更新日期:2020-10-20
  • Three-month outcomes in hospitalized COVID-19 patients
    medRxiv. Neurol. Pub Date : 2020-10-18
    Jude P Savarraj; Angela B Burkett; Sarah N Hinds; Atzhiry S Paz; Andres R Assing; Shivanki Juneja; Gabriela D Colpo; Luis F Torres; Aaron M Gusdon; Louise McCullough; Huimahn A Choi

    To date over 36 million people have been infected with the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). While the vast majority will survive, many may be left with residual effects. Acute neurologic symptoms including encephalitis, acute myopathic quadriplegia, strokes and seizures have been reported in COVID-19.1 Anecdotally

    更新日期:2020-10-19
  • Ethical Considerations during the Informed Consent Process for Acute Ischemic Stroke in International Clinical Trials
    medRxiv. Neurol. Pub Date : 2020-10-18
    Tiffany R. Bellomo; Jennifer A. Fokas; Clare Anderson; Noah Tsao; Christopher Becker; Rachel Gioscia-Ryan; William J. Meurer

    Introduction: Obtaining informed consent from acute ischemic stroke patients poses many challenges, especially in the context of a research setting. Specifically, consenting for alternative acute ischemic stroke treatments to the standard of care, Tissue Plasminogen Activator (tPA), can cause delays leading to increased time to reperfusion and worse outcomes. Objectives: We sought to investigate the

    更新日期:2020-10-19
  • Microscale dynamics of electrophysiological markers of epilepsy
    medRxiv. Neurol. Pub Date : 2020-10-16
    Jimmy C Yang; Angelique C Paulk; Sang Heon Lee; Mehran Ganji; Daniel J Soper; Pariya Salami; Daniel Cleary; Mirela Simon; Douglas Maus; Jong Woo Lee; Brian Nahed; Pamela Jones; Daniel P Cahill; Garth Rees Cosgrove; Catherine J Chu; Ziv Williams; Eric Halgren; Shadi Dayeh; Sydney S Cash

    Objective: Interictal discharges (IIDs) and high frequency oscillations (HFOs) are neurophysiologic biomarkers of epilepsy. In this study, we use custom poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) microelectrodes to better understand their microscale dynamics. Methods: Electrodes with spatial resolution down to 50μm were used to record intraoperatively in 30 subjects. For IIDs

    更新日期:2020-10-17
  • p-tau/Aβ42 Ratio Associates with Cognitive Decline in Alzheimer's disease, Mild Cognitive Impairment, and Cognitively Unimpaired Older Adults
    medRxiv. Neurol. Pub Date : 2020-10-16
    Ruchika Shaurya Prakash; Michael R. McKenna; Oyetunde Gbadeyan; Rebecca Andridge; Douglas W. Scharre

    INTRODUCTION: The most well-studied biomarkers in AD are CSF amyloid beta-42 (Aβ42), tau, p-tau, and the ratio p-tau/Aβ42. The ratiometric measure of p-tau/Aβ42 shows the best diagnostic accuracy, and correlates reliably with metrics of cognition in unimpaired participants. However, no study has examined the impact of the CSF p-tau/Aβ42 ratio in predicting cognitive decline in both healthy and AD individuals

    更新日期:2020-10-17
  • Quantitative assessment on the severity degree of Alzheimer dementia by algebraic analysis on cortical thickness profiles of human brains
    medRxiv. Neurol. Pub Date : 2020-10-16
    Sangyeol Kim; Seongjun Park; Iksoo Chang

    Alzheimer disease (AD) affects profoundly the quality of human life. Quantifying the severity degree of Alzheimer dementia for an individual person is critical for the early diagnose and prescription for delaying the further dementia progression. However, the quantitative diagnose for human subjects of the mild cognitively impairment (MCI) or AD with the different degree of dementia severity is a difficult

    更新日期:2020-10-17
  • CN-105 in Participants with Acute SupraTentorial IntraCerebral Hemorrhage (CATCH) Trial
    medRxiv. Neurol. Pub Date : 2020-10-15
    Michael L. James; Jesse Troy; Nahaniel Nowacki; Jordan Komisarow; Christa B. Swisher; Kristi Tucker; Kevin Hatton; Marc A. Babi; Bradrord B. Worrall; Charles Andrews; Daniel Woo; Peter G. Kranz; Christopher Lascola; Maureen Maughan; Daniel T. Laskowitz; CATCH Investigators

    Background: Endogenous apoliloprotein E mediates neuroinflammatory responses and recovery after brain injury. Exogenously administered apolipoprotein E-mimetic peptides can effectively penetrate the brain and down-regulate acute inflammation. CN-105 is a novel apolipoprotein E-mimetic pentapeptide with excellent preclinical evidence as an acute intracerebral hemorrhage (ICH) therapeutic. The CN-105

    更新日期:2020-10-16
  • Local and Distant responses to single pulse electrical stimulation reflect different forms of connectivity
    medRxiv. Neurol. Pub Date : 2020-10-15
    Britni Crocker; Lauren Ostrowski; Ziv M Williams; Darin D Dougherty; Emad N Eskandar; Alik S Widge; Catherine J Chu; Sydney S Cash; Angelique C Paulk

    Background: Measuring connectivity in the human brain can involve innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including the use of external probing stimuli, such as direct electrical stimulation. Objective/Hypothesis: To examine how different measures of connectivity correlate with one another, we compared 'passive' measures

    更新日期:2020-10-16
  • Automatic detection of generalized paroxysmal fast activity in interictal EEG using time-frequency analysis
    medRxiv. Neurol. Pub Date : 2020-10-15
    Amir Omidvarnia; Aaron E.L. Warren; Linda L. Dalic; Mangor Pedersen; Graeme D. Jackson

    Objective: Markup of generalized interictal epileptiform discharges (IEDs) on EEG is an important step in the diagnosis and characterization of epilepsy. However, manual EEG mark-up is a time-consuming, subjective, and highly specialized task where the human reviewer needs to visually inspect a large amount of data to facilitate accurate clinical decisions. The objective of this study was to develop

    更新日期:2020-10-16
  • Tracking the Progression & Influence of Beta-Amyloid Plaques Using Percolation Centrality and Collective Influence Algorithm: A Study using PET images
    medRxiv. Neurol. Pub Date : 2020-10-14
    Gautam Kumar Baboo; Raghav Prasad; Pranav Mahajan; Veeky Baths

    Network analysis allows investigators to explore the many facets of brain networks, particularly the proliferation of disease using graph theory to model the disease movement. The disruption in brain networks in Alzheimer's disease (AD) is due to the abnormal accumulation of beta-amyloid plaques and tau protein tangles. In this study, the potential use of percolation centrality to study the movement

    更新日期:2020-10-15
  • alpha4beta2* Nicotinic Cholinergic Receptor Target Engagement in Parkinson Disease
    medRxiv. Neurol. Pub Date : 2020-10-14
    Roger L. Albin; Martijn L.T.M. Muller; Nicolaas I. Bohnen; Cathie Spino; Martin Sarter; Robert A. Koeppe; Ashley Szpara; Cindy Lustig; William T. Dauer

    Objective: Attentional function deficits secondary to degeneration of brain cholinergic systems are significant contributors to gait-balance deficits in Parkinson disease (PD). To assess whether alpha4beta2* nicotinic acetylcholine receptor (nAChR) stimulation improves attention and gait-balance function, we performed a target engagement study of the alpha4beta2* nAChR partial agonist varenicline.

    更新日期:2020-10-15
  • SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability
    medRxiv. Neurol. Pub Date : 2020-10-13
    Fernanda Crunfli; Victor Corasolla Carregari; Flavio Protasio Veras; Pedro Henrique Vendramini; Aline Gazzola Fragnani Valenca; Andre Saraiva Leao Marcelo Antunes; Carolina Brandao-Teles; Giuliana da Silva Zuccoli; Guilherme Reis-de-Oliveira; Licia C. Silva-Costa; Verônica Monteiro Saia-Cereda; Ana Campos Codo; Pierina Lorencini Parise; Daniel A. Toledo-Teixeira; Gabriela Fabiano de Souza; Stéfanie

    COVID-19 patients may exhibit neuropsychiatric and/or neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild or no respiratory symptoms and are associated with altered cerebral cortical thickness. Using an independent cohort, we found histopathological signs of brain damage in 19% of individuals who died of COVID-19

    更新日期:2020-10-13
  • Two modes of inhibitory neuronal shutdown distinctly amplify seizures in humans
    medRxiv. Neurol. Pub Date : 2020-10-13
    Omar J Ahmed; Tibin T John; Shyam Kumar Sudhakar; Ellen KW Brennan; Alcides Lorenzo Gonzalez; Jason S Naftulin; Emad Eskandar; Joseph R Madsen; G. Rees Cosgrove; Andrew S Blum; N Stevenson Potter; George A Mashour; Leigh R Hochberg; Sydney S Cash

    Inhibitory neurons are critical for normal brain function but dysregulated in disorders such as epilepsy. At least two theories exist for how inhibition may acutely decrease during a seizure: hyperpolarization of fast-spiking (FS) inhibitory neurons by other inhibitory neurons, or depolarization block (DB) of FS neurons resulting in an inability to fire action potentials. Firing rate alone is unable

    更新日期:2020-10-13
  • Individual-level response adaptive crossover trial design for epilepsy: structure and simulation
    medRxiv. Neurol. Pub Date : 2020-10-13
    Wesley T Kerr; Xingruo Zhang; John M Stern

    Trials of antiseizure medications involve static group assignments for treatments with pre-specified durations. We propose a response-adaptive crossover design using basic statistical assumptions regarding both seizure count and duration of treatment to determine when a participant can change group assignment. We modelled seizure frequency as a Poisson process and estimated the likelihood that seizure

    更新日期:2020-10-13
  • An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing
    medRxiv. Neurol. Pub Date : 2020-10-13
    Eleanor L S Conole; Anna J Stevenson; Claire Green; Sarah E Harris; Susana Muñoz Maniega; Mathew A Harris; Mark E Bastin; Joanna M Wardlaw; Ian M Deary; Veronique E Miron; Heather C Whalley; Riccardo E Marioni; Simon R Cox

    Low-level chronic inflammation increases with age and is associated with cognitive decline. DNA methylation (DNAm) levels may provide more stable reflections of cumulative inflammatory burden than traditional serum approaches. Using structural and diffusion MRI data from 521 individuals aged 73, we demonstrate that a DNAm proxy of C-Reactive Protein (CRP) shows significantly (on average 6.4-fold) stronger

    更新日期:2020-10-13
  • Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer's disease
    medRxiv. Neurol. Pub Date : 2020-10-09
    Nathalie Giroud; Margaret Pichora-Fuller; Paul Mick; Walter Wittich; Faisal Al-Yawer; Sana Rehan; Joseph B. Orange; Natalie Phillips

    Hearing loss in healthy older adults is associated with accelerated brain volume loss; however, little is known about this association in those with or at risk for dementia. Using data from the COMPASS-ND study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (SCD, N=35), mild cognitive impairment

    更新日期:2020-10-11
  • How deep brain stimulation and levodopa affect gait variability in Parkinson disease
    medRxiv. Neurol. Pub Date : 2020-10-09
    Zi Su; Salil Patel; Bronwyn Gavine; Tim Buchanan; Marko Bogdanovic; Nagaraja Sarangmat; Alexander Green; Tipu Aziz; James FitzGerald; Chrystalina Antoniades

    Background: Disorders of gait are a very common feature of Parkinsons Disease. We examined how deep brain stimulation of the subthalamic nucleus (STN DBS) and dopaminergic medication affect gait and more specifically its rhythmicity. Objectives: We accurately quantified multiple gait parameters in Parkinsons patients during on and off stages of their treatment (levodopa or STN DBS) to compare and contrast

    更新日期:2020-10-11
  • Distinct serum anti-Aβ antibody patterns in hemorrhagic and inflammatory cerebral amyloid angiopathy manifestations
    medRxiv. Neurol. Pub Date : 2020-10-09
    Yannick Chantran; Jean Capron; Diana Doukhi; Johanna Felix; Melanie Feroul; Florian Kruse; Thomas Chaigneau; Guillaume Dorothee; Thibault Allou; Xavier Ayrignac; Zina Barrou; Thomas de Broucker; Corina Cret; Guillaume Turc; Roxane Peres; Anne Wacongne; Marie Sarazin; Dimitri Renard; Charlotte Cordonnier; Sonia Alamowitch; Pierre Aucouturier

    Abstract Objective: To study blood anti-Aβ antibodies in the context of spontaneous inflammatory or hemorrhagic CAA manifestations, which are similar to complications occurring after monoclonal anti-Aβ antibody immunotherapies. Methods: In this case-control study, serum anti-Aβ antibody isotype, concentration, avidity, and reactivity toward soluble or fibrillary Aβ1-40 and Aβ1-42 isoforms were assessed

    更新日期:2020-10-11
  • Near Fibre Electromyography
    medRxiv. Neurol. Pub Date : 2020-10-09
    Mathew Piasecki; Daniel W Stashuk; Oscar Garnes C Estruch

    Near fibre electromyography (NFEMG) is the use of specifically high-pass filtered motor unit potential (MUPs) (i.e. near fibre MUPs (NFMs)) extracted from needle-detected EMG signals for the examination of changes in motor unit (MU) morphology and electrophysiology caused by neuromuscular disorders or ageing. The concepts of NFEMG, the parameters used, including NFM duration and dispersion, which relates

    更新日期:2020-10-11
  • Polygenic associations and causal inferences between serum immunoglobulins and amyotrophic lateral sclerosis
    medRxiv. Neurol. Pub Date : 2020-10-09
    Xu Chen; Xiaojun Shen; Xuzhuo Zhang; Yiqiang Zhan; Fang Fang

    Chronic inflammation might contribute to the development of amyotrophic lateral sclerosis (ALS), the relationship between serum immunoglobulins and risk of ALS remains however unclear. In order to overcome limitations like reverse causation and residual confounding commonly seen in the observational studies, we applied molecular epidemiological analyses to examine the polygenic and causal associations

    更新日期:2020-10-11
  • Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade
    medRxiv. Neurol. Pub Date : 2020-10-07
    Katarzyna Winek; Sebastian Lobentanzer; Bettina Nadorp; Serafima Dubnov; Claudia Dames; Sandra Jagdmann; Gilli Moshitzky; Benjamin Hotter; Christian Meisel; David S Greenberg; Sagiv Shifman; Jochen Klein; Shani Shenhar-Tsarfaty; Andreas Meisel; Hermona Soreq

    Stroke is a leading cause of death and disability. Recovery depends on a delicate balance between inflammatory responses and immune suppression, tipping the scale between brain protection and susceptibility to infection. Peripheral cholinergic blockade of immune reactions fine-tunes this immune response, but its molecular regulators are unknown. Here, we report a regulatory shift in small RNA types

    更新日期:2020-10-07
  • In vivo assessment of neurodegeneration in Spinocerebellar Ataxia type 7
    medRxiv. Neurol. Pub Date : 2020-10-07
    Jacob A Parker; Shabbir H Merchant; Sanaz Attaripour-Isfahani; Hyun Joo Cho; Patrick McGurrin; Brian P Brooks; Albert R La Spada; Mark Hallett; Laryssa A Huryn; Silvina G Horovitz

    Spinocerebellar Ataxia type 7 (SCA7) is a neurodegenerative disease characterized by progressive cerebellar ataxia and retinal degeneration. Increasing loss of visual function complicates the use of clinical scales to track the progression of motor symptoms, hampering our ability to develop accurate biomarkers of disease progression, and thus test the efficacy of potential treatments. In this cross-sectional

    更新日期:2020-10-07
  • Cycles of self-reported seizure likelihood correspond to yield of diagnostic epilepsy monitoring
    medRxiv. Neurol. Pub Date : 2020-10-07
    Philippa J Karoly; Dominique Eden; Ewan S Nurse; Mark J Cook; Janelle Taylor; Sonya Dumanis; Mark P Richardson; Benjamin H Brinkmann; Dean R Freestone

    Objective: Video-electroencephalography (vEEG) is an important component of epilepsy diagnosis and management. Nevertheless, inpatient vEEG monitoring fails to capture seizures in up to one third of patients during diagnostic and pre-surgical monitoring. We hypothesized that personalized seizure forecasts could be used to optimize the timing of vEEG and improve diagnostic yield. Methods: We used a

    更新日期:2020-10-07
  • Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis
    medRxiv. Neurol. Pub Date : 2020-10-07
    Catriona R Stewart; Michael S Stringer; Yulu Shi; Michael J Thrippleton; Joanna M Wardlaw

    Cerebral small vessel disease is a major contributor to stroke and dementia, characterised by white matter hyperintensities (WMH) on neuroimaging. WMH are associated with reduced cerebral blood flow (CBF) cross-sectionally, though longitudinal associations remain unclear. We updated a 2016 meta-analysis, identifying 30 studies, 27 cross-sectional (n=2956) and 3 longitudinal (n=440), published since

    更新日期:2020-10-07
  • Vagus Nerve and Stomach Synucleinopathy in Parkinson Disease, Incidental Lewy Body Disease and Normal Elderly Subjects: Evidence Against the Body-First Hypothesis
    medRxiv. Neurol. Pub Date : 2020-10-06
    Thomas G Beach; Charles H Adler; Lucia I Sue; Holly A Shill; Erika Driver-Dunckley; Shyamal H Mehta; Anthony J Intorcia; Michael J Glass; Jessica E Walker; Richard Arce; Courtney M Nelson; Geidy E Serrano

    Braak and others have proposed that Lewy-type alpha-synucleinopathy (aSyn) in Parkinson disease (PD) may arise from an exogenous pathogen that passes across the gastric mucosa and then is retrogradely transported up the vagus nerve to the medulla. We tested this body-first hypothesis by immunohistochemically staining stomach and vagus nerve tissue from an autopsy series of 111 normal elderly subjects

    更新日期:2020-10-07
  • SMORASO-DT : A hybrid machine learning classification model to classify individuals based on working memory load in mental arithmetic task
    medRxiv. Neurol. Pub Date : 2020-10-05
    Shivabalan K R; BROTOTO DEB; Arivan Ramachandran; Shivam Goel

    Nonlinear dynamics and chaos theory are being widely used nowadays in neuroscience to characterize complex systems within which the change of the output is not proportional to the change applied at the input. Such nonlinear systems compared to linear systems, often appear chaotic, unpredictable, or counterintuitive, however, yet their behaviour is not mapped out as random. Thus, hidden potential of

    更新日期:2020-10-06
  • A machine learning-based holistic approach for the diagnosis of patients suffering from different conditions within the Alzheimer's disease spectrum
    medRxiv. Neurol. Pub Date : 2020-10-05
    Noemi Massetti; Alberto Granzotto; Manuela Bomba; Stefano Delli Pizzi; Alessandra Mosca; Reinhold Scherer; Marco Onofrj; Stefano L. Sensi

    Alzheimer's disease (AD) and related dementias are neurodegenerative conditions driven by a multifactorial etiology. Growing clinical and epidemiological evidence indicates that the convergence of many polygenic, epigenetic, environmental, vascular, and metabolic factors shapes the risk, onset, and progression of the disease. Capturing and framing the complexity of these factors represent an unmet

    更新日期:2020-10-06
  • Large meta-analysis of genome-wide association studies expands knowledge of the genetic etiology of Alzheimer disease and highlights potential translational opportunities
    medRxiv. Neurol. Pub Date : 2020-10-04
    Celine Bellenguez; Fahri Kucukali; Iris Jansen; Victor Andrade; Sonia Morenau-Grau; Najaf Amin; Benjamin Grenier-Boley; Luca Kleideman; Peter Holsman; Pablo Garcia; Rafael Campos Martin; Adam Naj; Yang Qiong; Joshua C Bis; Vincent Damotte; Sven Vander Lee; Anne Boland; Marcos Costa; Julien Chapuis; Vilmentas Giedraitis; Maria J Bullido; Adolfo Lopez de Munain; Jordi Perez-Tur; Pascual Sanchez-Juan;

    Deciphering the genetic landscape of Alzheimer disease (AD) is essential to define the pathophysiological pathways involved and to successfully translate genomics to potential tailored medical care. To generate the most complete knowledge of the AD genetics, we developed through the European Alzheimer Disease BioBank (EADB) consortium a discovery meta-analysis of genome-wide association studies (GWAS)

    更新日期:2020-10-04
  • Clinical and genetic analysis of Costa Rican patients with Parkinson's disease.
    medRxiv. Neurol. Pub Date : 2020-09-30
    Gabriel Torrealba-Acosta; Eric Yu; Tanya Lobo-Prada; Javier Ruiz-Martínez; Ana Gorostidi-Pagola; Ziv Gan-Or; Kenneth Carazo-Céspedes; Jaime Fornaguera-Trías

    Abstract Background: Parkinson's disease (PD) involves environmental risk and protective factors as well as genetic variance. Most of the research in genomics has been done in subjects of European ancestry leading to sampling bias and leaving Latin American populations underrepresented. Objective: We sought to phenotype and genotype Costa Rican PD cases and controls. Methods: We enrolled 118 PD patients

    更新日期:2020-10-02
  • Neuroanatomical Considerations for Optimizing Thalamic Deep Brain Stimulation in Tourette Syndrome
    medRxiv. Neurol. Pub Date : 2020-09-30
    Takashi Morishita; Yuki Sakai; Hitoshi Iida; Saki Yoshimura; Atsushi Ishii; Shinsuke Fujioka; Saori Tanaka; Tooru Inoue

    Background: Deep brain stimulation (DBS) of the centromedian (CM) thalamic nucleus has reportedly been used to treat severe Tourette syndrome (TS) with promising outcomes; however, it remains unclear how DBS electrode position and stimulation parameters modulate the specific area and related networks. We aimed to evaluate the relationships between the anatomical location of stimulation fields and clinical

    更新日期:2020-10-02
  • Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-09-30
    Semra Smajic; Cesar Augusto Prada-Medina; Zied Landoulsi; Carola Dietrich; Javier Jarazo; Jana Henck; Saranya Balachandran; Sinthuja Pachchek; Christopher M Morris; Paul Antony; Bernd Timmermann; Sascha Sauer; Jens C Schwamborn; Patrick May; Anne Grunewald; Malte Spielmann

    Parkinson's disease (PD) etiology is associated with genetic and environmental factors that lead to a loss of dopaminergic neurons. However, the functional interpretation of PD-associated risk variants and how other midbrain cells contribute to this neurodegenerative process are poorly understood. Here, we profiled >41,000 single-nuclei transcriptomes of postmortem midbrain tissue from 6 idiopathic

    更新日期:2020-10-02
  • Spectrum of spinal cord involvement in COVID-19: A systematic review
    medRxiv. Neurol. Pub Date : 2020-09-30
    Ritwick Mondal; Shramana Deb; Gourav Shome; Upasana Ganguly; Durjoy Lahiri; Julian Benito Leon

    Background and aims- Recent reports reveal incidences of spinal cord involvement in form of para-infectious or post-infectious myelitis raising potential concerns about the possibilities of SARS-CoV-2 behind the pathogenesis of spinal cord demyelination. In this study, we intend to summarise so far available pieces of evidence documenting SARS-CoV-2 mediated spinal demyelination in terms of clinical

    更新日期:2020-10-02
  • Altered EEG markers of synaptic plasticity in a human model of NMDA receptor deficiency: anti-NMDA receptor encephalitis
    medRxiv. Neurol. Pub Date : 2020-09-30
    Silvano R. Gefferie; Angelina Maric; Hanne Critelli; Sophie Gueden; Gerhard Kurlemann; Salome Kurth; Margherita Nosadini; Barbara Plecko; Maya Ringli; Kevin Rostásy; Stefano Sartori; Bernhard Schmitt; Agnese Suppiej; Patrick Van Bogaert; Flavia M. Wehrle; Reto Huber; Bigna K. Bölsterli

    Plasticity of synaptic strength and density is a vital mechanism enabling memory consolidation, learning, and neurodevelopment. It is strongly dependent on the intact function of N-methyl-D-aspartate receptors (NMDAR). The importance of NMDAR is further evident as their dysfunction is involved in many diseases such as schizophrenia, Alzheimer's disease, neurodevelopmental disorders, and epilepsies

    更新日期:2020-10-02
  • The influence of socioeconomic deprivation on dementia mortality, age at death and quality of diagnosis: a nationwide death records study in England and Wales 2001-2017
    medRxiv. Neurol. Pub Date : 2020-09-29
    Mark Jitlal; Guru NK Amirthalingam; Tasvee Karania; Eve Parry; Aidan Neligan; Ruth Dobson; Alastair J Noyce; Charles R Marshall

    Background. Socioeconomic deprivation is postulated to be an important determinant of dementia risk, mortality, and access to diagnostic services. Nevertheless, premature mortality from other causes and under-representation of deprived individuals in research cohorts may lead to this effect being overlooked. Methods. We obtained Office of National Statistics (ONS) mortality data where dementia was

    更新日期:2020-09-29
  • Sleep in severe disorders of consciousness: 24-h behavioral and polysomnographic recording
    medRxiv. Neurol. Pub Date : 2020-09-27
    Isabella Mertel; Yuri G. Pavlov; Christine Barner; Friedemann Müller; Susanne Diekelmann; Boris Kotchoubey

    Background: Sleep-wakefulness cycles are an essential diagnostic criterion for Disorders of Consciousness (DOC), differentiating prolonged DOC from coma. Specific sleep features, like the presence of sleep spindles, are an important marker for the prognosis of recovery from DOC. Based on increasing evidence for a link between sleep and neuronal plasticity, understanding sleep in DOC might facilitate

    更新日期:2020-09-28
  • Dynamic connectivity predicts acute motor impairment and recovery post-stroke
    medRxiv. Neurol. Pub Date : 2020-09-27
    Anna K Bonkhoff; Anne Rehme; Lukas Hensel; Caroline Tscherpel; Lukas Volz; Flor Espinoza; Harshvardhan Gazula; Victor Vergara; Gereon Fink; Vince Calhoun; Natalia Rost; Christian Grefkes

    Objective Thorough assessment of cerebral dysfunction after acute brain lesions is paramount to optimize predicting short- and long-term clinical outcomes. The potential of dynamic resting-state connectivity for prognosticating motor recovery has not been explored so far. Methods We built random forest classifier-based prediction models of acute upper limb motor impairment and recovery after stroke

    更新日期:2020-09-28
  • An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study
    medRxiv. Neurol. Pub Date : 2020-09-27
    Lars B Hindenes; Asta Kristine Håberg; Ellisiv B Mathiesen; Torgil R Vangberg

    Objective The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. Methods In a cross-sectional

    更新日期:2020-09-28
  • Aerobic exercise improves hippocampal blood flow for hypertensive APOE4 carriers
    medRxiv. Neurol. Pub Date : 2020-09-25
    Carolyn S Kaufman; Robyn A Honea; Joseph Pleen; Rebecca J Lepping; Amber Watts; Jill K Morris; Sandra A Billinger; Jeffrey M Burns; Eric Vidoni

    Background: Evidence increasingly suggests cerebrovascular dysfunction plays an early and important role in the pathogenesis of Alzheimer′s disease (AD). Studies have shown the strongest known genetic risk factor for sporadic AD, Apolipoprotein E4 (APOE4), may act synergistically with vascular risk factors to promote dementia development. Aerobic exercise may attenuate cognitive decline at least partially

    更新日期:2020-09-25
  • NeuroPM toolbox: integrating Molecular, Neuroimaging and Clinical data for Characterizing Neuropathological Progression and Individual Therapeutic Needs
    medRxiv. Neurol. Pub Date : 2020-09-25
    Yasser Iturria-Medina; Felix Carbonell; Atoussa Assadi; Quadri Adewale; Ahmed F. Khan; Robert Baumeister; Lazaro M Sanchez-Rodriguez

    There is a critical need for a better multiscale and multifactorial understanding of neurological disorders, covering from genes to neuroimaging to clinical factors and treatments effects. Here we present NeuroPM-box, a cross-platform, user-friendly and open-access software for characterizing multiscale and multifactorial brain pathological mechanisms and identifying individual therapeutic needs. The

    更新日期:2020-09-25
  • More than words: Extra-Sylvian neuroanatomic networks support indirect speech act discourse comprehension in behavioral variant frontotemporal dementia
    medRxiv. Neurol. Pub Date : 2020-09-25
    Meghan Healey; Erica Howard; Molly Ungrady; Christopher Olm; Naomi Nevler; David J Irwin; Murray Grossman

    Indirect speech acts responding 'I forgot to wear my watch today' to someone who asked for the time are ubiquitous in daily conversation, but are understudied in current neurobiological models of language. To comprehend an indirect speech act like this one, listeners must not only decode the lexical-semantic content of the utterance, but also make a pragmatic, bridging inference. This inference allows

    更新日期:2020-09-25
  • Genetic Associations with Age at Dementia Onset in the PSEN1 E280A Colombian Kindred
    medRxiv. Neurol. Pub Date : 2020-09-25
    J. Nicholas Cochran; Juliana Acosta-Uribe; Lucia Madrigal; David Aguillón; Gloria P. Garcia; Margarita M. Giraldo; Natalia Acosta-Baena; Francisco Piedrahita; Diana Alzate; Hugo E. Lopez; Kevin Roberts; Devin Absher; Richard M. Myers; Francisco Lopera; Kenneth S. Kosik

    Background: Genetic associations with Alzheimer's disease (AD) age at onset (AAO) have revealed genetic variants with the potential for therapeutic application. Such studies in late onset AD are limited by population heterogeneity and co-morbidities associated with aging. Studies to date in ADAD (autosomal dominant AD) have been limited by their small sample size. The large Colombian kindred presented

    更新日期:2020-09-25
  • Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations
    medRxiv. Neurol. Pub Date : 2020-09-25
    Uladzislau Rudakou; Eric Yu; Lynne M Krohn; Jennifer A Ruskey; Farnaz Asayesh; Yves Dauvilliers; Dan Spiegelman; Lior Greenbaum; Stanley Fahn; Cheryl H Waters; Nicolas Dupré; Guy Rouleau; Sharon Hassin-Baer; Edward A Fon; Roy N Alcalay; Ziv Gan-Or

    Genome-wide association studies (GWAS) have identified numerous loci associated with Parkinson's disease. The specific genes and variants that drive the associations within the vast majority of these loci are unknown. We aimed to perform a comprehensive analysis of selected genes to determine the potential role of rare and common genetic variants within these loci. We fully sequenced 32 genes from

    更新日期:2020-09-25
  • Left hemisphere lateralization of epileptic focus can be more frequent in temporal lobe epilepsy surgical patients with no consensus associated with depression lateralization.
    medRxiv. Neurol. Pub Date : 2020-09-24
    Graciane Radaelli; Fernanda Majolo; Eduardo Leal-Conceicao; Francisco Souza Santos; Vinicius Escobar; Gislaine Baroni; Gabriele Zanirati; Mirna Portuguez; Fulvio alexandre Scorza; Jaderson Costa da Costa

    Temporal Lobe Epilepsy (TLE) is considered to be the most common form of epilepsy, and it has been seen that most patients are refractory to antiepileptic drugs. A strong association of this ailment has been established with psychiatric comorbidities, primarily mood and anxiety disorders. The side of epileptogenic may contribute to depressive and anxiety symptoms; thus, in this study, we performed

    更新日期:2020-09-25
  • Low lymphocyte count is a risk factor for Parkinsons disease
    medRxiv. Neurol. Pub Date : 2020-09-24
    Melanie Peta Jensen; Benjamin M Jacobs; Ruth Dobson; Sara Bandres-Ciga; Cornelis Blauwendraat; Anette Schrag; The International Parkinsons Disease Genomics Consortium; Alastair J Noyce

    Importance: Biomarkers for the early detection of Parkinsons disease (PD) are needed. Patients with PD display differences in peripheral blood biomarkers of immune function, including leukocyte differential counts and C-reactive protein (CRP), compared to controls. These differences may be useful biomarkers to predict PD, and may shed light on PD pathogenesis. Objectives: To identify whether peripheral

    更新日期:2020-09-24
  • LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson′s disease
    medRxiv. Neurol. Pub Date : 2020-09-24
    Yuri L Sosero; Eric Yu; Lynne Krohn; Uladzislau Rudakou; Kheireddin Mufti; Jennifer Ruskey; Farnaz Asayesh; Sandra B Laurent; Dan Spiegelman; Stanley Fahn; Cheryl Waters; S. Pablo Sardi; International Parkinson Disease Genomics Consortium (IPDGC); Sara Bandres Ciga; Roy N Alcalay; Ziv Gan-Or; Konstantin Senkevich

    Background and objectives: The LRRK2 p.G2019S Parkinson′s disease (PD) variant is associated with elevated glucocerebrosidase (GCase) activity in peripheral blood. We aimed to evaluate the association of other LRRK2 variants with PD and its association with GCase activity. Methods: LRRK2 and GBA were fully sequenced in 1,309 PD patients and 648 controls from the Columbia and PPMI cohorts, in which

    更新日期:2020-09-24
  • Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.
    medRxiv. Neurol. Pub Date : 2020-09-24
    Owen A Williams; Andrea T Shafer; Evian Perez Rivra; Yang An; Bennett Allen Landman; Luigi Ferrucci; Susan M Resnick

    INTRODUCTION: Little is known about longitudinal decline in white matter (WM) microstructure and its associations with cognition in preclinical Alzheimers disease (AD). METHODS: Longitudinal diffusion tensor imaging and neuropsychological testing from 50 older adults who subsequently developed mild cognitive impairment or dementia (subsequently impaired, SI) and 200 cognitively normal controls. Rates

    更新日期:2020-09-24
  • Reliable detection of focal-onset seizures in the human anterior nucleus of the thalamus using non-linear machine learning
    medRxiv. Neurol. Pub Date : 2020-09-23
    Emilia Toth; Sachin S Kumar; Ganne Chaitanya; Kristen Riley; Karthi Balasubramanian; Sandipan Pati

    Objective: There is an unmet need to develop seizure detection algorithms from brain regions outside the epileptogenic cortex. The study aimed to demonstrate the feasibility of classifying seizures and interictal states from local field potentials (LFPs) recorded from the human thalamus- a subcortical region remote to the epileptogenic cortex. We tested the hypothesis that spectral and entropy-based

    更新日期:2020-09-23
  • Heterogeneous distribution of tau pathology in the behavioral variant of Alzheimer's disease
    medRxiv. Neurol. Pub Date : 2020-09-23
    Ellen H. Singleton; Oskar Hansson; Anke A. Dijkstra; Renaud La Joie; William G. Mantyh; Pontus Tideman; Erik Stomrud; Antoine Leuzy; Maurits Johansson; Olof Strandberg; Ruben Smith; Evi Berendrecht; Bruce L Miller; Leonardo Iaccarino; Lauren Edwards; Amelia Storm; Emma Wolters; Emma M. Coomans; Denise Visser; Sandeep S.V. Golla; Hayel Tuncel; Femke Bouwman; John van Swieten; Janne M. Papma; Bart van

    Objective: The clinical phenotype of the rare behavioral variant of Alzheimer's disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in bvAD, in-vivo and ex-vivo, using PET and postmortem examination. Methods: For the tau PET study, seven amyloid-β positive bvAD patients underwent [18F]flortaucipir

    更新日期:2020-09-23
  • Structural Connectivity in Children Treated with Therapeutic Hypothermia for Neonatal Encephalopathy
    medRxiv. Neurol. Pub Date : 2020-09-23
    Arthur P C Spencer; Jonathan C W Brooks; Naoki Masuda; Hollie Byrne; Richard Lee-Kelland; Sally Jary; Marianne Thoresen; James Tonks; Marc Goodfellow; Frances M Cowan; Ela Chakkarapani

    Neonatal encephalopathy leads to high risk of death and neurodevelopmental impairment, including cerebral palsy. Treatment with therapeutic hypothermia offers improved outcome. However, recent studies have shown that school-age children treated with therapeutic hypothermia for neonatal encephalopathy have reduced performance on cognitive and motor tests, attention difficulties, slower reaction times

    更新日期:2020-09-23
  • Contrasting the brain imaging features of MOG-Antibody disease, with AQP4-Antibody NMOSD and Multiple Sclerosis
    medRxiv. Neurol. Pub Date : 2020-09-23
    Silvia Messina; Romina Mariano; Adriana Roca-Fernandez; Ana Cavey; Maciej Jurynczyk; Maria Isabel Leite; Massimiliano Calabrese; Mark Jenkinson; Jacqueline Palace

    Neuromyelitis optica associated with aquaporin-4-antibodies (NMOSD-AQP4) and myelin oligodentrocyte-glycoprotein antibody-associated disorder (MOGAD) have been recently recognised as different from multiple sclerosis. Although conventional MRI may help distinguish multiple sclerosis from antibody-mediated diseases, the use of quantitative and non-conventional imaging may give more pathological information

    更新日期:2020-09-23
  • MIND diet associated with later onset of Parkinson's disease
    medRxiv. Neurol. Pub Date : 2020-09-22
    Avril Metcalfe-Roach; Adam Yu; Ella Golz; Kristen Sundvick; Mihai Cirstea; Daniel Kliger; Liam Foulger; Melissa Mackenzie; Brett Finlay; Silke Cresswell

    Background: The MIND diet has been linked with prevention of Alzheimer's disease and cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). Objective: To determine whether MIND diet adherence is associated with the age of Parkinson's disease onset in a manner superior to that of the Mediterranean diet. Methods: Food Frequency Questionnaires from 167 participants

    更新日期:2020-09-23