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Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: An in vitro and in vivo study Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-11 Feifei Lu, Qing Wu, Jiaming Lei, Yanhong Zhou, Yifei Liu, Ni Zhu, You Yu, Li Lin, Meichun Hu
To investigate the therapeutic effects of Zeaxanthin (Zea), one of the oxidized xanthophyll carotenoids belonging to the isoprenoids, on inhibiting the angiogenesis and tumor growth of glioblastoma (GBM) via an and study. The effects of Zea on the proliferation, adhesion, migration and invasion of human GBM cell lines were detected by cell proliferation assay, cell adhesion assay and Transwell assay
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Structure-activity relationship and cytotoxicity of the new thiosemicarbazide derivatives and their Cu(II) complexes against prostate and melanoma cancer cells Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-07 Bartłomiej Rogalewicz, Monika Pitucha, Marcin Świątkowski, Ewelina Humeniuk, Grzegorz Adamczuk, Monika Drózd, Zbigniew Karczmarzyk, Elżbieta Kuśmierek, Krzysztof Strzelec, Anita Raducka, Waldemar Wysocki, Alina Olender, Anna Kozub, Dorota Kowalczuk, Ewa Poleszak, Agnieszka Czylkowska
In this study, eighteen new ligands () containing a thiosemicarbazide core were synthesized and characterized in terms of physicochemical properties, molecular docking and biological activity. The structures of eleven ligands were investigated using X-Ray diffraction and Hirschfeld Surface analysis. To study the structure-activity relationship, the organic ligands contained pyridin-2-ylmethyl, pyridin-3-ylmethyl
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Oxidized phospholipid-protein adducts: The future targets of interest Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-07 Helena Beatriz Ferreira, M. Rosário Domingues
Phospholipids are key biomolecules with important roles as components of membranes, lipoproteins and as signalling molecules. However, phospholipids are quite prone to oxidation. Upon oxidation they generate several types of oxidation products including long chain oxidation products, as hydroperoxyl and hydroxy derivatives, and highly reactive oxidation products, like small aldehydes and truncated
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Peculiarities of ion homeostasis in neurons containing calcium-permeable AMPA receptors Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-05 Sergei A. Maiorov, Bakhytzhan K. Kairat, Alexey V. Berezhnov, Valery P. Zinchenko, Sergei G. Gaidin, Artem M. Kosenkov
Glutamate excitotoxicity accompanies numerous brain pathologies, including traumatic brain injury, ischemic stroke, and epilepsy. Disturbances of the ion homeostasis, mitochondria dysfunction, and further cell death are considered the main detrimental consequences of excitotoxicity. It is well known that neurons demonstrate different vulnerability to pathological exposures. In this regard, neurons
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The crucial role of NRF2 in erythropoiesis and anemia: Mechanisms and therapeutic opportunities Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-05 Lei Yang, Yong Chen, Sheng He, Duonan Yu
The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in cellular defense against oxidative and electrophilic stresses. Recent research has highlighted the significance of NRF2 in normal erythropoiesis and anemia. NRF2 regulates genes involved in vital aspects of erythroid development, including hemoglobin catabolism, inflammation, and iron homeostasis in erythrocytes
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Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-01 Beena Thazhackavayal Baby, Aniruddha Murahar Kulkarni, Prasanna Kumar Reddy Gayam, Kuzhuvelil B. Harikumar, Jesil Mathew Aranjani
Hedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it is associated with oncogenesis and is responsible for disease progression and poor clinical outcomes. Hedgehog signaling mediates downstream actions via Glioma Associated Oncogene Homolog (GLI) transcription factors. Inhibiting
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Iron overload and programmed bone marrow cell death: Potential mechanistic insights Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-01 Wanat Wudhikulprapan, Siriporn C. Chattipakorn, Nipon Chattipakorn, Sirinart Kumfu
Iron overload has detrimental effects on bone marrow mesenchymal stem cells (BMMSCs), cells crucial for bone marrow homeostasis and hematopoiesis support. Excessive iron accumulation leads to the production of reactive oxygen species (ROS), resulting in cell death, cell cycle arrest, and disruption of vital cellular pathways. Although apoptosis has been extensively studied, other programmed cell death
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Network of extracellular vesicles surrounding senescent cells Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-03-01 Hikaru Okawa, Yoko Tanaka, Akiko Takahashi
Extracellular vesicles (EVs) are small lipid bilayers released from cells that contain cellular components such as proteins, nucleic acids, lipids, and metabolites. Biological information is transmitted between cells via the EV content. Cancer and senescent cells secrete more EVs than normal cells, delivering more information to the surrounding recipient cells. Cellular senescence is a state of irreversible
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Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-29 Hebatalla Mohamed, Stella A. Child, Daniel Z. Doherty, John B. Bruning, Stephen G. Bell
The cytochrome P450 family of heme metalloenzymes (CYPs) catalyse important biological monooxygenation reactions. contains a gene encoding a CYP105Q4 enzyme of unknown function. Other members of the CYP105 CYP family have key roles in bacterial metabolism including the synthesis of secondary metabolites. We produced and purified the cytochrome P450 enzyme CYP105Q4 to enable its characterization. Several
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Kinetic characterization of a flavin-dependent monooxygenase from the insect food crop pest, Zonocerus variegatus Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-29 Sydney B. Johnson, Kathryn Paasch, Starlina Shepard, Pablo Sobrado
or the painted grasshopper, is a food crop pest endemic in Western and Central Africa. Agricultural industries in these regions rely heavily on natural defense mechanisms to control the grasshopper population such as plant-secreted alkaloid compounds. In recent years, the population has continued to rise due to acquired resistance to alkaloids. Here we focus on the kinetic characterization of a flavin-dependent
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Cellular HSF1 expression is induced during HIV-1 infection by activation of its promoter mediated through the cooperative interaction of HSF1 and viral Nef protein Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-28 Alapani Mitra, Anindita Dasgupta, Debashis Mitra
The Human Immunodeficiency Virus-1 (HIV-1) tends to activate cellular promoters driving expression of pro-viral genes by complex host-virus interactions for productive infection. We have previously demonstrated that expression of such a positive host factor HSF1 (heat shock factor 1) is elevated during HIV-1 infection; however, the mechanism remains to be elucidated. In the present study, we therefore
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RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-27 Wenhui Dong, Xiaofei Li, Lulu Cheng, Jing Yang, Ziyan Zhao, Xihui Qiang, Pengmei Li, Ju Wu, Lianyi Guo
The purpose of this study was to explore the role of RAE1 in the invasion and metastasis of gastric cancer (GC) cells. RAE1 expression in GC cells was determined by reverse-transcription polymerase chain reaction (qRT-PCR) and Western blotting (WB). Cell models featuring RAE1 gene silencing and overexpression were constructed by lentiviral transfection; The proliferation, migration, and invasion ability
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Inhibiting apoptosis and GSDME-mediated pyroptosis attenuates hepatic injury in septic mice Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-24 Na Lu, Hongqian Qin, Zhaofei Meng, Ying Yu, Qin Gao, Zhipeng Cheng, Chuanmiao Liu, Junfeng Hu
Sepsis is characterized by severe inflammation and organ dysfunction resulting from a dysregulated organismal response to infection. Although pyroptosis has been presumably shown to be a major cause of multiple organ failure and septic death, whether gasdermin E (GSDME)-mediated pyroptosis occurs in septic liver injury and whether inhibiting apoptosis and GSDME-mediated pyroptosis can attenuate septic
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Purification and characterisation of the platelet-activating GPVI/FcRγ complex in SMALPs Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-22 Xueqing Wang, Alexandre Slater, Sarah C. Lee, Neale Harrison, Naomi L. Pollock, Saskia E. Bakker, Stefano Navarro, Bernhard Nieswandt, Tim R. Dafforn, Ángel García, Steve P. Watson, Michael G. Tomlinson
The collagen/fibrin(ogen) receptor, glycoprotein VI (GPVI), is a platelet activating receptor and a promising anti-thrombotic drug target. However, while agonist-induced GPVI clustering on platelet membranes has been shown to be essential for its activation, it is unknown if GPVI dimerisation represents a unique conformation for ligand binding. Current GPVI structures all contain only the two immunoglobulin
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GPCRs in the round: SMA-like copolymers and SMALPs as a platform for investigating GPCRs Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-22 Hoor Ayub, Rebecca J. Murray, Gestél C. Kuyler, Farhaan Napier-Khwaja, Joseph Gunner, Tim R. Dafforn, Bert Klumperman, David R. Poyner, Mark Wheatley
G-protein-coupled receptors (GPCRs) are the largest family of membrane proteins, regulate a plethora of physiological responses and are the therapeutic target for 30–40% of clinically-prescribed drugs. They are integral membrane proteins deeply embedded in the plasma membrane where they activate intracellular signalling via coupling to G-proteins and β-arrestin. GPCRs are in intimate association with
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Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-22 Na Wang, Yanan Sheng, Yutong Liu, Yaoting Guo, Jun He, Jinsong Liu
As one of the oldest infectious diseases in the world, tuberculosis (TB) is the second most deadly infectious disease after COVID-19. Tuberculosis is caused by (Mtb), which can attack various organs of the human body. Up to now, drug-resistant TB continues to be a public health threat. Pyrazinamide (PZA) is regarded as a sterilizing drug in the treatment of TB due to its distinct ability to target
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Structure and dynamics of the cyanobacterial regulator SipA Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-21 José L. Neira, María Luisa López-Redondo, Ana Cámara-Artigas, Alberto Marina, Asunción Contreras
The small, 78-residue long, regulator SipA interacts with the non-bleaching sensor histidine kinase (NblS). We have solved the solution structure of SipA on the basis of 990 nuclear Overhauser effect- (NOE-) derived distance constraints. The average pairwise root-mean-square deviation (RMSD) for the twenty best structures for the backbone residues, obtained by CYANA, was 1.35 ± 0.21 Å, and 1.90 ± 0
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Insights into membrane interactions and their therapeutic potential Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-21 Calum Upton, Joseph Healey, Alice J. Rothnie, Alan D. Goddard
Recent research into membrane interactions has uncovered a diverse range of therapeutic opportunities through the bioengineering of human and non-human macromolecules.
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Activation of adenosine A2B receptor alleviates myocardial ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress and restoring autophagy flux Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-21 Feng He, Fuyu Wang, Hanmin Xiang, Yunna Ma, Qing Lu, Yun Xia, Huimin Zhou, Yanlin Wang, Jianjuan Ke
Myocardial ischemia-reperfusion injury (MIRI) poses a significant threat to patients with coronary heart disease. Adenosine A2A receptors have been known as a protective role in MIRI by regulating autophagy, so we assumed that activation of adenosine A2B receptor (A2BAR) might exert a similar effect during MIRI and underlying mechanism be related to proteostasis maintenance as well. hearts were subjected
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Designing a structure-function alphabet of helix based on reduced amino acid clusters Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-20 Siqi Yang, Dongyang Liu, Yancheng Song, Yuchao Liang, Haoyu Yu, Yongchun Zuo
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Dye-decolorizing peroxidase of Thermobifida halotolerance displays complex kinetics with both substrate inhibition and apparent positive cooperativity Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-19 Hegne Pupart, Tiit Lukk, Priit Väljamäe
Dye-decolorizing peroxidases (DyPs) have been intensively investigated for the purpose of industrial dye decolorization and lignin degradation. Unfortunately, the characterization of these peroxidases is hampered by their non-Michaelis-Menten kinetics, exemplified by substrate inhibition and/or positive cooperativity. Although often observed, the underlying mechanisms behind the unusual kinetics of
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The catalytic action of human d-lactate dehydrogenase is severely inhibited by oxalate and is impaired by mutations triggering d-lactate acidosis Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-17 Alessandra Stefan, Alberto Mucchi, Alejandro Hochkoeppler
-lactate dehydrogenases are known to be expressed by prokaryotes and by eukaryotic invertebrates, and over the years the functional and structural features of some bacterial representatives of this enzyme ensemble have been investigated quite in detail. Remarkably, a human gene coding for a putative -lactate dehydrogenase (DLDH) was identified and characterized, disclosing the occurrence of alternative
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tRNA-derived fragments: Key determinants of cancer metastasis with emerging therapeutic and diagnostic potentials Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-16 Mohammad Salehi, Mohammad Javad Kamali, Aliakbar Rajabzadeh, Shima Minoo, Hamidreza Mosharafi, Fatemeh Saeedi, Abdolreza Daraei
Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical
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Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-15 Yue Lai, Shushan Guo, Qiongwei Tang, Gaomei Chang, Hui Zhang, Bo Li, Qilin Feng, Ke Hu, Zhijian Xu, Xuejie Gao, Qikai Zhang, Hongfei Yi, Dongliang Song, Yifei Zhang, Yu Peng, Haiyan Cai, Weiliang Zhu, Jumei Shi
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Although treatment options have improved, a large proportion of patients show low survival rates, highlighting an urgent need for novel therapeutic strategies. The aim of this study was to investigate the efficacy of the new small-molecule compound dihydrocelastrol (DHCE), acquired through the structural modification
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Interrogating l-fuconate dehydratase with tartronate and 3-hydroxypyruvate reveals subtle differences within the mandelate racemase-subgroup of the enolase superfamily Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-12 Laura C. McGary, Christopher M. Fetter, Minglu Gu, Meghan C. Hamilton, Himank Kumar, Oliver P. Kuehm, Colin D. Douglas, Stephen L. Bearne
Enzymes of the enolase superfamily share a conserved structure and a common partial reaction (, metal-assisted, Brønsted base-catalyzed enol(ate) formation). The architectures of the enolization apparatus at the active sites of the mandelate racemase (MR)-subgroup members MR and -fuconate dehydratase (FucD) are almost indistinguishable at the structural level. Tartronate and 3-hydroxypyruvate (3-HP)
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Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-12 Tianzhu Guan, Ning Li, Xiangxiu Xu, Dan Xiong, Bo Wang, Lixia Xiao, Weikang Yang, Ganghui Chu, Abdulla Yusuf, Jie Zhang, Weiming Yue
Sinomenine is a pure alkaloid isolated from . This study is aimed to investigate the critical role of the nuclear factor erythroid 2-related factor 2 (Nrf2)-kelch-like ECH-associated protein-1(Keap1)-antioxidant response element (ARE) antioxidative signaling pathway in protecting sinomenine against HO-induced oxidative injury. Cytotoxicity and antioxidant experiments to initially determine the protective
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Hyperglycemia – A culprit of podocyte pathology in the context of glycogen metabolism Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-11 Olga Żołnierkiewicz, Dorota Rogacka
Prolonged disruption in the balance of glucose can result in metabolic disorders. The kidneys play a significant role in regulating blood glucose levels. However, when exposed to chronic hyperglycemia, the kidneys' ability to handle glucose metabolism may be impaired, leading to an accumulation of glycogen. Earlier studies have shown that there can be a significant increase in glucose storage in the
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Molecular basis of ligand recognition specificity of flavone glucosyltransferases in Nemophila menziesii Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-10 Kazutaka Murayama, Miyuki Kato-Murayama, Toshiaki Hosaka, Naoko Okitsu, Yoshikazu Tanaka, Mikako Shirouzu
Of the more than 100 families of glycosyltransferases, family 1 glycosyltransferases catalyze glycosylation using uridine diphosphate (UDP)-sugar as a sugar donor and are thus referred to as UDP-sugar:glycosyl transferases. The blue color of the flower is derived from metalloanthocyanin, which consists of anthocyanin, flavone, and metal ions. Flavone 7--β-glucoside-4′--β-glucoside in the plant is sequentially
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YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1 Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-09 Guozhi Yin, Siying Jia, Youju Zhang, Yao Xian, Yong Guo, Qingguang Liu
Zinc finger protein 131 (ZNF131), a member of BTB-ZF transcription factors, has been previously reported as an oncogene in several human cancers. However, the function and underlying mechanism of ZNF131 in hepatocellular carcinoma (HCC) are still unclear. In our study, the upregulated expression of ZNF131 mRNA was confirmed in HCC tissues by analyzing the TCGA and GEO datasets. The immunohistochemical
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Cinnamaldehyde attenuates TNF-α induced skeletal muscle loss in C2C12 myotubes regulation of protein synthesis, proteolysis, oxidative stress and inflammation Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-08 Nirmaljeet Kaur, Prachi Gupta, Vikas Dutt, Onkar Sharma, Sanjeev Gupta, Anita Dua, Elisha Injeti, Ashwani Mittal
Inflammation is the primary driver of skeletal muscle wasting, with oxidative stress serving as both a major consequence and a contributor to its deleterious effects. In this regard, regulation of both can efficiently prevent atrophy and thus will increase the rate of survival (Meng and Yu, 2010) [1]. With this idea, we hypothesize that preincubation of Cinnamaldehyde (CNA), a known compound with anti-oxidative
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TRIM34 suppresses non-small-cell lung carcinoma via inducing mTORC1-dependent glucose utilization and promoting cellular death Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-07 Pengfei Zhang, Zhida Chen, Juan Li, Hui Mao, Yi Hu
Non-small-cell lung carcinoma (NSCLC) is a type of pernicious tumor, which owns high morbidity and mortality. TRIM34 has a stimulative role in cell apoptosis and a suppressive role in inflammation. However, no studies were focused on the regulatory impacts of TRIM34 in NSCLC. This study aimed to examine the underlying regulatory effects of TRIM34 in NSCLC. TRIM34 exhibited lower expression in NSCLC
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PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-05 Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Kuo Shen, Hao Guan
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UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-30 Zhengguang Geng, Wenbo Chen, Qinju Lu, Bao Fu, Xiaoyun Fu
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A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2 Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-01 James I. Mitchell-White, Deborah A. Briggs, Sarah J. Mistry, Hannah A. Mbiwan, Barrie Kellam, Nicholas D. Holliday, Stephen J. Briddon, Ian D. Kerr
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Biomolecular fingerprints of the effect of zoledronic acid on prostate cancer stem cells: Comparison of 2D and 3D cell culture models Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-01 Günnur Güler, Eda Acikgoz, Günel Mukhtarova, Gulperi Oktem
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GDNF facilitates the differentiation of ADSCs to Schwann cells and enhances nerve regeneration through GDNF/MTA1/Hes1 axis Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-01 Weixia Cai, Yang Liu, Ting Zhang, Peng Ji, Chenyang Tian, Jiaqi Liu, Zhao Zheng
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Interaction of the antifungal ketoconazole and its diphenylphosphine derivatives with lipid bilayers: Insights into their antifungal action Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-02-01 Andreia Bento-Oliveira, Radosław Starosta, Rodrigo F.M. de Almeida
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Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-26 Asma Akhter, Sultan Alouffi, Uzma Shahab, Rihab Akasha, Mohd Fazal-Ur-Rehman, Mohamed E. Ghoniem, Naved Ahmad, Kirtanjot Kaur, Ramendra Pati Pandey, Ahmed Alshammari, Firoz Akhter, Saheem Ahmad
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Anti-glycating and anti-cytotoxic effect of silibinin on albumin at early glycation: A physiochemical study Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-31 Km Neelofar, Jamshed Haneef, Jamal Ahmad, Khursheed Alam, Rana Zaidi
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Collagen I protects human keratinocytes HaCaT against UVB injury via restoring PINK1/parkin-mediated mitophagy Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-26 Yuying Zhu, Wendie Xiang, Sijun He, Zhao San, Weiwei Liu, Jin Wu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
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Impact of chlorogenic acid on surface and phase properties of cholesterol-enriched phosphatidylcholine membranes Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-28 Jimena del P. Cejas, Antonio S. Rosa, Agustín N. González Paz, Edgardo A. Disalvo, María de A. Frías
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A vivid outline demonstrating the benefits of exosome-mediated drug delivery in CNS-associated disease environments Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-23 Rachayeeta Ray, Sougata Ghosh Chowdhury, Parimal Karmakar
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Prediction and biological analysis of yeast VDAC1 phosphorylation Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-28 André D. Sousa, Ana Luisa Costa, Vítor Costa, Clara Pereira
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Tanshinone IIA attenuates osteoarthritis via inhibiting aberrant angiogenesis in subchondral bone Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-20 Hong-Zhou Li, Dong Han, Rui-Feng Ao, Zhi-Hai Cai, Guo-Zheng Zhu, Di-Zheng Wu, Jia-Wen Gao, Jing-shen Zhuang, Chen Tu, Kai Zhao, Zhi-Yong Wu, Zhao-Ming Zhong
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Role of HIF-1α in hypercoagulable state of COPD in rats Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-20 Ruicheng Deng, Xiaoyong Ma, Huifang Zhang, Juanxia Chen, Meifang Liu, Lijun Chen, Haiyang Xu
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Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-19 Jianhui Chen, Zuoman Zhang, Ling Feng, Weihua Liu, Xin Wang, Haishan Chen, Hequn Zou
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Ferulic acid protects against gamma-radiation induced liver injury via regulating JAK/STAT/Nrf2 pathways Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-19 Rania A. Gawish, Esraa M. Samy, Maha M. Aziz
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Naringin-induced M2 macrophage polarization facilitates osteogenesis of BMSCs and improves cranial bone defect healing in rat Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-19 Jiaohong Liu, Fuyao Li, Yuanting Ouyang, Zhikang Su, Ding Chen, Zitian Liang, Zhiyi Zhang, Ruofei Lin, Tao Luo, Lvhua Guo
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Characterization of haloacid dehalogenase superfamily acid phosphatase from Staphylococcus lugdunensis Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-15 Harry Kaur, Surabhi Rode, Sandra KP, Jai Krishna Mahto, Md Shahid Alam, Deena Nath Gupta, Bibekananda Kar, Jitin Singla, Pravindra Kumar, Ashwani Kumar Sharma
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A multifactorial study of in situ antioxidant activity of modified GrO in myocardial reperfusion injury using the Langerdorff model Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-15 Kateryna V. Sencha-Hlevatska, Yury I. Sementsov, Sergey V. Zhuravskyi, Lidia A. Mys, Yulia P. Korkach, Hristo Kolev, Vadym F. Sagach, Yulia V. Goshovska
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Hemin competitively inhibits HSPA8 ATPase activity mitigating its foldase function Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-10 Alok Kumar Pandey, Vishal Trivedi
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Echinacoside stimulates myogenesis and ATP-dependent thermogenesis in the skeletal muscle via the activation of D1-like dopaminergic receptors Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-11 Kiros Haddish, Jong Won Yun
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The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-09 Emilia Reszczyńska, Anna Wiśniewska-Becker, Mariusz Duda, Alicja Sęk, Wiesław I. Gruszecki, Agnieszka Hanaka
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Functional regulation of the protein phosphatase PPM1M by phosphorylation at multiple sites with Ser/Thr-Pro motifs Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-14 Jin Osawa, Masataka Karakawa, Aoi Taniguchi, Yuiko Inui, Chika Usuki, Atsuhiko Ishida, Isamu Kameshita, Noriyuki Sueyoshi
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Computer-made peptide RQ18 acts as a dual antifungal and antibiofilm peptide though membrane-associated mechanisms of action Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-11 Claudiane Vilharroel Almeida, Caio Fernando Ramalho de Oliveira, Luís Henrique de Oliveira Almeida, Suellen Rodrigues Ramalho, Camila de Oliveira Gutierrez, Janaina de Cassia Orlandi Sardi, Octávio Luiz Franco, Marlon Henrique Cardoso, Maria Ligia Rodrigues Macedo
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FKBP38 suppresses endometrial cancer cell proliferation and metastasis by inhibiting the mTOR pathway Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-11 Yunjing Yan, Shuai Wang, Zongmeng Zhang, Minyi Tang, Allan Z. Zhao, Zhuang Li, Xiaoli Wu, Fanghong Li
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Myopathy-causing mutation R91P in the TPM3 gene drastically impairs structural and functional properties of slow skeletal muscle tropomyosin γβ-heterodimer Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-06 Anastasiia D. Gonchar, Natalia A. Koubassova, Galina V. Kopylova, Anastasia M. Kochurova, Victoria V. Nefedova, Daria S. Yampolskaya, Daniil V. Shchepkin, Sergey Y. Bershitsky, Andrey K. Tsaturyan, Alexander M. Matyushenko, Dmitrii I. Levitsky
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G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Arch. Biochem. Biophys. (IF 3.9) Pub Date : 2024-01-10 Julia Tutzauer, D. Stephen Serafin, Tobias Schmidt, Björn Olde, Kathleen M. Caron, L.M. Fredrik Leeb-Lundberg