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Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation Radiat. Res. (IF 3.4) Pub Date : 2023-12-07 Tarun K. Garg, Sarita Garg, Isabelle R. Miousse, Stephen Y. Wise, Alana D. Carpenter, Oluseyi O. Fatanmi, Frits van Rhee, Vijay K. Singh, Martin Hauer-Jensen
Currently, no radioprotectors have been approved to mitigate hematopoietic injury after exposure to ionizing radiation. Acute ionizing radiation results in damage to both hematopoietic and immune system cells. Pre-exposure prophylactic agents are needed for first responders and military personnel. In this study, the ability of gamma-tocotrienol (GT3), a promising radioprotector and antioxidant, to
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Radiation-Chemical Perspective of the Radiobiology of Pulsed (High Dose-Rate) Radiation (FLASH): A Postscript Radiat. Res. (IF 3.4) Pub Date : 2023-12-05 Peter Wardman
An earlier commentary (Wardman P, Radiat Res. 2020; 194:607-617) discussed possible chemical reaction pathways that might be involved in the differential responses of tissues to high- vs. low-dose-rate irradiation, focusing on reactions between radicals, and radiolytic depletion of a chemical influencing radiosensitivity. This brief postscript updates discussion to consider recent modeling and experimental
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Effect of Infliximab on Radiation-Induced Submandibular Gland Dysfunction in Rats Radiat. Res. (IF 3.4) Pub Date : 2023-12-04 Pengxin Zhang, Maimaitituerxun Abudunaibi, Qi Zhao, Yanhui Wu, Guliziba Aihaiti, Shihan Wu, Jia Qi, Liang Shi, Hui Xu
Inflammatory response is one of the essential parts of various pathogenic mechanisms of radiation-induced salivary dysfunction. The effect of decreasing the levels of inflammatory cytokines on alleviating submandibular gland injuries after irradiation is unclear. This study aimed to explore the effect of the antibody against tumor necrosis factor-alpha, infliximab, on radiation-induced submandibular
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Pharmacokinetics and Biodistribution of 16,16 dimethyl Prostaglandin E2 in Non-Irradiated and Irradiated Mice and Non-Irradiated Non-Human Primates Radiat. Res. (IF 3.4) Pub Date : 2023-11-28 Brooke Langevin, Pratibha Singh, P. Artur Plett, Carol H. Sampson, Andi Masters, Allison Gibbs, Eduardo De Faria, Sarah Triesler, Andrew Zodda, Isabel L. Jackson, Christie M. Orschell, Mathangi Gopalakrishnan, Louis M. Pelus
Exposure to high-dose ionizing radiation can lead to life-threatening injuries and mortality. Bone marrow is the most sensitive organ to radiation damage, resulting in the hematopoietic acute radiation syndrome (H-ARS) with the potential sequelae of infection, hemorrhage, anemia, and death if untreated. The development of medical countermeasures (MCMs) to protect or mitigate radiation injury is a medical
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Development of a Multi-Organ Radiation Injury Model with Precise Dosimetry with Focus on GI-ARS Radiat. Res. (IF 3.4) Pub Date : 2023-11-28 Vidya P. Kumar, Kefale Wuddie, Alena Tsioplaya, Alia Weaver, Gregory P. Holmes-Hampton, Sanchita P. Ghosh
The goal of this study was to establish a model of partial-body irradiation (PBI) sparing 2.5% of the bone marrow (BM2.5-PBI) that accurately recapitulates radiological/nuclear exposure scenarios. Here we have reported a model which produces gastrointestinal (GI) damage utilizing a clinical linear accelerator (LINAC) with precise dosimetry, which can be used to develop medical countermeasures (MCM)
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Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair. Radiat. Res. (IF 3.4) Pub Date : 2023-11-28 John W Warmenhoven,Nicholas T Henthorn,Aimee L McNamara,Samuel P Ingram,Michael J Merchant,Karen J Kirkby,Jan Schuemann,Harald Paganetti,Kevin M Prise,Stephen J McMahon
The induction and repair of DNA double-strand breaks (DSBs) are critical factors in the treatment of cancer by radiotherapy. To investigate the relationship between incident radiation and cell death through DSB induction many in silico models have been developed. These models produce and use custom formats of data, specific to the investigative aims of the researchers, and often focus on particular
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Assessment of Cataract Risk after Diagnostic Head CT Scan Radiation Exposure in Ontario, Canada Radiat. Res. (IF 3.4) Pub Date : 2023-11-28 Pirouz Emami, Katherine Gaudreau, Mark P. Little, Choonsik Lee, Brian Moroz, Douglas R. Boreham, Christopher Thome
Ionizing radiation is one of the known risk factors for cataract development, however, there is still debate regarding the level of risk after low dose exposures. One of the largest sources of radiation exposure to the lens of the eye is diagnostic CT scans. The aim of this study was to examine whether ionizing radiation associated with head CT scans increases cataract risk in residents of Ontario
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A Novel Platform for Evaluating Dose Rate Effects on Oxidative Damage to Peptides: Toward a High-Throughput Method to Characterize the Mechanisms Underlying the FLASH Effect. Radiat. Res. (IF 3.4) Pub Date : 2023-11-28 Sayan Gupta,Jamie L Inman,Jared De Chant,Lieselotte Obst-Huebl,Kei Nakamura,Shawn M Costello,Susan Marqusee,Jian-Hua Mao,Louis Kunz,Ryan Paisley,Marie-Catherine Vozenin,Antoine M Snijders,Corie Y Ralston
High dose rate radiation has gained considerable interest recently as a possible avenue for increasing the therapeutic window in cancer radiation treatment. The sparing of healthy tissue at high dose rates relative to conventional dose rates, while maintaining tumor control, has been termed the FLASH effect. Although the effect has been validated in animal models using multiple radiation sources, it
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miR-146a-5p Alleviates Radiation-Induced Liver Fibrosis by Regulating PTPRA-SRC Signaling in Mice. Radiat. Res. (IF 3.4) Pub Date : 2023-11-28 Bao-Ying Yuan,Yuan Zhuang,Zhi-Feng Wu,Xiao-Mei Zhao,Li Zhang,Gen-Wen Chen,Zhao-Chong Zeng
Patients with hepatobiliary tumors who accept radiotherapy are at risk for radiation-induced liver fibrosis. MicroRNAs (miRNAs) have been implicated in the pathogenesis of radiation-induced liver damage and possess potential as novel biomarkers and therapeutic targets. However, the role of miR-146a-5p in radiation-induced liver fibrosis is less well understood. The current study was designed to evaluate
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Single-fraction Radiation Treatment Dose Response in a Genetically Engineered Mouse Model of Medulloblastoma. Radiat. Res. (IF 3.4) Pub Date : 2023-11-22 Kevin J Tu,Connor E Stewart,Nerissa T Williams,Yan Ma,Lixia Luo,Debosir Ghosh,Loren B Weidenhammer,Scott R Floyd,Yi Fan,David G Kirsch,Mark Oldham,Zachary J Reitman
Medulloblastoma is the most common malignant brain tumor of children. Although standard of care radiotherapy for pediatric medulloblastoma (PM) can lead to long-term remission or cure in many patients, it can also cause life-long cognitive impairment and other adverse effects. The pathophysiological mechanisms involved in radiation-induced cerebral damage are incompletely understood, and their elucidation
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Chemokine Receptor CXCR4 Radioligand Targeted Therapy Using 177Lutetium-pentixather for Pulmonary Neuroendocrine Cancers Radiat. Res. (IF 3.4) Pub Date : 2023-11-21 Melissa A. Fath, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Ann M. Tomanek-Chalkley, Stephen A. Graves, James R. Howe, Thomas M. O’Dorisio, Prerna Rastogi, Andrew M. Bellizzi, M Sue O’Dorisio, Yusuf Menda, Douglas R. Spitz
Intermediate to high-grade lung neuroendocrine tumors (NETs; i.e., atypical carcinoid tumors) and neuroendocrine carcinomas (NECs) are currently difficult to cure. These tumors were found to express the CXCR4 G-protein coupled receptor that can be targeted with radioligands. PCR and flow cytometric analysis of lung NET and NEC cell lines using an anti-CXCR4 antibody demonstrated that all cell lines
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Naive CD4 T Cells Highly Expressing the Inflammatory Chemokine Receptor CXCR3 Increase with Age and Radiation Exposure in Atomic Bomb Survivors Radiat. Res. (IF 3.4) Pub Date : 2023-11-21 Kengo Yoshida, Munechika Misumi, Mika Yamaoka, Seishi Kyoizumi, Waka Ohishi, Hiromi Sugiyama, Tomonori Hayashi, Yoichiro Kusunoki
The numbers of naive T cells that react to novel pathogens not yet encountered by an immune system, decrease during aging, mainly due to age-associated involution of the thymus. CD45RA+ naive CD4 T cells consist of heterogeneous populations, including highly CXCR3-expressing cells that appear during the homeostatic proliferation of naive T cells and exhibit enhanced type-1 inflammatory phenotypes.
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Heme Biosynthesis is Crucial for Cell Survival and Mitochondrial OXPHOS after X Irradiation Radiat. Res. (IF 3.4) Pub Date : 2023-11-21 Tomoki Bo, Koen Van Wijk, Osamu Nakajima
Heme is an essential component of the hemoproteins involved in the mitochondrial electron transport chain (ETC). Cancer cells have been reported to display high heme levels and increased activity of heme-containing proteins. Consistently, inhibition of heme biosynthesis by the ALAD inhibitor succinylacetone (SA) has been shown to reduce tumor cell survival. These observations indicate that heme biosynthesis
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Iron Deposition in the Bone Marrow and Spleen of Nonhuman Primates with Acute Radiation Syndrome. Radiat. Res. (IF 3.4) Pub Date : 2023-11-16 Regina M Day,W Bradley Rittase,John E Slaven,Sang-Ho Lee,Grace V Brehm,Dmitry T Bradfield,Jeannie M Muir,Stephen Y Wise,Oluseyi O Fatanmi,Vijay K Singh
The risk of exposure to high levels of ionizing radiation from nuclear weapons or radiological accidents is an increasing world concern. Partial- or total-body exposure to high doses of radiation is potentially lethal through the induction of acute radiation syndrome (ARS). Hematopoietic cells are sensitive to radiation exposure; white blood cells primarily undergo apoptosis while red blood cells (RBCs)
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Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA. Radiat. Res. (IF 3.4) Pub Date : 2023-11-14 Sara Dumit,Guthrie Miller,Olivier Grémy,Deepesh Poudel,Luiz Bertelli,John A Klumpp
This work describes an analysis, using a previously established chelation model, of the bioassay data collected from a worker who received delayed chelation therapy following a plutonium-238 inhalation. The details of the case have already been described in two publications. The individual was treated with Ca-DTPA via multiple intravenous injections and then nebulizations beginning several months after
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Thermoluminescence Characteristics of Copper and Terbium Co-Doped Lithium Tetraborate Glass. Radiat. Res. (IF 3.4) Pub Date : 2023-11-06 Nabil El-Faramawy,Mohamed El-Kinawy,Shrouk Farouk,Mohamed Sabry,Hassan F El-Nashar,Alessia Mafodda,Clemens Woda
In this study, the preparation and characterization of copper (Cu) and terbium (Tb) co-doped lithium borate glass using spectroscopic and thermoluminescence techniques are reported. A thermal treatment was introduced to increase the degree of crystallinity. The thermoluminescence glow curve signal of the samples displayed upon exposure to beta radiation was measured and analyzed. It was found that
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Remodeling of Chromatin Accessibility Regulates the Radiological Responses of NSCLC A549 Cells to High-LET Carbon Ions. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Qian Li,Xiaofei Wang,Shengmin Xu,Biao Chen,Tao Wu,Jie Liu,Guoping Zhao,Lijun Wu
Carbon-ion radiation therapy (CIRT) may offer remarkable advantages in cancer treatment with its unique physical and biological characteristics. However, the underlying epigenetic regulatory mechanisms of cancer response to CIRT remain to be identified. In this study, we showed consistent but different degrees of biological effects induced in NSCLC A549 cells by carbon ions of different LET. The genome-wide
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CR6-Interacting Factor-1 Promotes Osteoclastogenesis Through the NF-κB Signaling Pathway after Irradiation. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Lixin Xiang,Fengjie Li,Yang Xiang,Weiwei Zhang,Dongling Shi,Xiaomei Zhang,Li Chen,Qian Ran,Zhongjun Li
Radiation exposure arising from radiotherapy may induce rapid bone loss and an increase in the extent of bone resorption. Reactive oxygen species (ROS) caused by radiation exposure play a crucial role during the process of osteoclastogenesis. However, the pathological mechanisms underlying radiation-induced osteoclastogenesis have yet to be fully elucidated. CR6-interacting factor-1 (Crif1) as a multifunctional
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Neurocognitive Function in Aged Survivors Exposed to Atomic Bomb Radiation In Utero: The Radiation Effects Research Foundation Adult Health Study. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Hiroko Kitamura,Kayoko Ishihara,Naohiro Kato,Munechika Misumi,Ayumi Hida,Michiko Yamada
Although some adverse effects on neurocognitive function have been reported in children and adolescents irradiated prenatally during the atomic bombings and the Chernobyl nuclear accident, little information is available for effects on the elderly. Here we evaluate the effects of prenatal exposure to atomic bomb radiation on subjective neurocognitive function in aged survivors. To evaluate neurocognitive
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LC3 Accelerated Brain-Lung Axis Abscopal Effects after Fractionated Whole-Brain Radiation by Promoting Motoneurons to Secrete Periostin. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Ke Zhang,Zhuojun Wu,Ying Zhao,Xinyu Qiu,Fang Li,Qiu Chen,Fengmei Cui
The effect of autophagy on the radiation-induced bystander effect (RIBE) in vivo is unclear. Here, the whole brains of microtubule-associated protein 1A/1B-light chain 3 (LC3) and C57BL/6 (B6) mice were irradiated once (10 Gy)(IR1), given 3 fractions in three weeks (IR3), or 6 fractions in six weeks (IR6). The median survival of LC3 mice was 56.5 days, and that of B6 mice was 65 days after IR6. LC3
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A Data-Driven Variance Reduction Technique for Efficiently Modelling Astronaut Radiation Doses in Spacecraft in High-Energy Isotropic Radiation Fields. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Liam D Moshovelis,Gail N Iles,Rick D Franich
The ionizing radiation exposure to crew on current and future space missions can significantly increase their health risks for cancers, degenerative diseases, and other acute and late effects. A common approach for estimating risk to crew is by completing stochastic (e.g., Monte Carlo) or deterministic particle transport simulations. Within the simulated environment, a small fraction of the particle
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Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Brianne R O'Leary,Amanda L Kalen,Amanda N Pope,Prabhat C Goswami,Joseph J Cullen
Pharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) preferentially sensitizes human pancreas ductal adenocarcinoma (PDAC) cells to radiation-induced toxicity compared to non-tumorigenic epithelial cells. Radiation-induced G2-checkpoint activation contributes to the resistance of cancer cells to DNA damage induced toxicity. We hypothesized that P-AscH- induced radio-sensitization of
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Effects of HZE-Particle Exposure Location and Energy on Brain Inflammation and Oxidative Stress in Rats. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Danielle S Cahoon,Bernard M Rabin,Derek R Fisher,Barbara Shukitt-Hale
Astronauts on exploratory missions will be exposed to particle radiation of high energy and charge (HZE particles), which have been shown to produce neurochemical and performance deficits in animal models. Exposure to HZE particles can produce both targeted effects, resulting from direct ionization of atoms along the particle track, and non-targeted effects (NTEs) in cells that are distant from the
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Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate. Radiat. Res. (IF 3.4) Pub Date : 2023-11-01 Shane R Solst,Kranti A Mapuskar,Claire H Graham,Sarah A King,Rana Rheem,Kyle Current,Bryan G Allen,Joseph M Caster,Douglas R Spitz,Michelle E Howard
Diffuse intrinsic pontine gliomas (DIPG) are an aggressive type of pediatric brain tumor with a very high mortality rate. Surgery has a limited role given the tumor's location. Palliative radiation therapy alleviates symptoms and prolongs survival, but median survival remains less than 1 year. There is no clear role for chemotherapy in DIPGs as trials adding chemotherapy to palliative radiation therapy
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Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure. Radiat. Res. (IF 3.4) Pub Date : 2023-10-30 Miho Noguchi,Tomokazu Ihara,Keiji Suzuki,Akinari Yokoya
Autophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed
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A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta). Radiat. Res. (IF 3.4) Pub Date : 2023-10-30 Allison M Tomasino,John D Olson,George W Schaaf,Anderson O Cox,Cristina M Furdui,J Mark Cline,Eric P Cohen
Late effects of total- or partial-body irradiation include chronic kidney injury (CKI), which increases morbidity and mortality. Glomerular filtration rate (GFR) is the gold standard measure of kidney function. Renal function markers, such as blood urea nitrogen (BUN) and serum creatinine (Cr), may not be higher than reference ranges until 50% or more of nephrons are affected. Currently available methods
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Regulation of Circulating miR-342-3p Alleviates the Radiation-Induced Immune System Injury. Radiat. Res. (IF 3.4) Pub Date : 2023-10-24 Wenjun Wei,Hao Bai,Tianyi Zhang,Shufan Cai,Yumeng Zhou,Min Liu,Yanan Zhang,Yaxiong Chen,Junrui Hua,Jinpeng He,Nan Ding,GuoYing Miao,Jufang Wang
Ionizing radiation in space, radiation devices or nuclear disasters are major threats to human health and public security. Expanding countermeasures for dealing with accidental or occupational radiation exposure is crucial for the protection of radiation injuries. Circulating microRNAs (miRNAs) have emerged as promising radiation biomarkers in recent years. However, the origin, distribution and functions
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Dosimetry of the PIM1 Pion Beam at the Paul Scherrer Institute for Radiobiological Studies of Mice. Radiat. Res. (IF 3.4) Pub Date : 2023-10-01 L Desorgher,A Stabilini,T Rostomyan,D Reggiani,W Hajdas,R M Marcinkowski,M-C Vozenin,C L Limoli,E G Yukihara,C Bailat
Significant past work has identified unexpected risks of central nervous system (CNS) exposure to the space radiation environment, where long-lasting functional decrements have been associated with multiple ion species delivered at low doses and dose rates. As shielding is the only established intervention capable of limiting exposure to the dangerous radiation fields in space, the recent discovery
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Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys. Radiat. Res. (IF 3.4) Pub Date : 2023-10-01 George W Schaaf,John D Olson,Greg O Dugan,Betsy A Pray,Jacob A Cleary,J Mark Cline
Testicular injury is a well-documented acute effect of radiation exposure, though little is known about recovery years after irradiation, especially at higher doses. We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation
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An Epidemiological Study of Lung Cancer and Selected Other Cancers among Namibian Uranium Workers. Radiat. Res. (IF 3.4) Pub Date : 2023-10-01 Raymond Agius,Evridiki Batistatou,Matthew Gittins,Steve Jones,Roseanne McNamee,Hanhua Liu,Amir Rashid,Martie van Tongeren,Gunhild von Oertzen,Richard Wakeford
The Rössing Uranium Limited (RUL) open-cast uranium mine in Namibia has operated since 1976. Studies of underground uranium miners from Europe and North America have shown increased cancer risks (principally lung cancer). We explored the association between radiation doses and selected cancers in RUL mineworkers. Employees with at least one-year of continuous employment between 1976 and 2010 were included
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Longitudinal Analysis of Leukocyte Total and Differential Count of Rhesus Macaques (Macaca mulatta) after Total-Body Irradiation. Radiat. Res. (IF 3.4) Pub Date : 2023-10-01 Yuiko Chino,John D Olson,George W Schaaf,J Mark Cline,Thomas E Johnson
Archival data of leukocyte count and the differentials obtained from control and irradiated Rhesus Macaques (Macaca mulatta) were statistically analyzed to understand the long-term effect of ionizing radiation exposure. Nine animals received total-body irradiation (TBI) of 7.2-8.4 Gy at 3-4 years old. Twelve animals served as age-matched controls with no radiation exposure. The complete blood cell
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Noninvasive Red Laser Intervention before Radiotherapy of Triple-negative Breast Cancer in a Murine Model. Radiat. Res. (IF 3.4) Pub Date : 2023-09-13 Camila R Silva,Saulo T Pereira,Daniela F T Silva,Lucas R De Pretto,Anderson Z Freitas,Carlos A Zeituni,Maria E C M Rostelato,Martha S Ribeiro
Radiotherapy is a well-established cancer treatment; it is estimated that approximately 52% of oncology patients will require this treatment modality at least once. However, some tumors, such as triple-negative breast cancer (TNBC), may present as radioresistant and thus require high doses of ionizing radiation and a prolonged period of treatment, which may result in more severe side effects. Moreover
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Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model Radiat. Res. (IF 3.4) Pub Date : 2023-09-13 Lina Abdelghany, Yong Xu, Reiko Sekiya, Chen Yan, Keiichi Jingu, Tao-Sheng Li
Nicaraven selectively protects normal tissue from radiation-induced injury. To further develop the clinical application of nicaraven for mitigating the side effects of cancer radiotherapy, we investigated the potential effect of nicaraven administration in radiation-induced inhibition of tumor growth. A subcutaneous tumor model was established in mice by the injection of Lewis lung cancer cells at
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Immune Dysfunction from Radiation Exposure Radiat. Res. (IF 3.4) Pub Date : 2023-09-13 David R. Cassatt, Thomas A. Winters, Mercy PrabhuDas
Exposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required
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Immune Dysfunction from Radiation Exposure Radiat. Res. (IF 3.4) Pub Date : 2023-09-13 Brynn A. Hollingsworth, Jennifer T. Aldrich, Cullen M. Case, Andrea L. DiCarlo, Corey M. Hoffman, Ann A. Jakubowski, Qian Liu, Shannon G. Loelius, Mercy PrabhuDas, Thomas A. Winters, David R. Cassatt
The hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune system may result in opportunistic infections and hemorrhage, which could lead to mortality. Inflammation triggered by tissue damage can also lead to additional local or widespread tissue damage. The immune system is responsible for tissue repair and restoration, which is made more challenging when it is in the
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Effect of Temozolomide Combined with Intensity Modulated Radiation Therapy on Serum Factor, Immune Function and Clinical Efficacy in Postoperative Glioma Patients. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Jinjin Yuan,Junqi Liu,Ruitai Fan,Zongwen Liu
To investigate the effect of Temozolomide combined with intensity modulated radiation therapy on serum factor, immune function and clinical efficacy in postoperative glioma patients. One hundred twenty-four patients with high-grade glioma admitted to the First Affiliated Hospital of Zhengzhou University were selected and randomly divided into the study group and the control group, with 62 cases in
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Comparison of Tumor Control and Skin Damage in a Mouse Model after Ultra-High Dose Rate Irradiation and Conventional Irradiation. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Kayla E A Duval,Ethan Aulwes,Rongxiao Zhang,Mahbubur Rahman,M Ramish Ashraf,Austin Sloop,Jacob Sunnerberg,Benjamin B Williams,Xu Cao,Petr Bruza,Alireza Kheirollah,Armin Tavakkoli,Lesley A Jarvis,Philip E Schaner,Harold M Swartz,David J Gladstone,Brian W Pogue,P Jack Hoopes
Recent studies suggest ultra-high dose rate radiation treatment (UHDR-RT) reduces normal tissue damage compared to conventional radiation treatment (CONV-RT) at the same dose. In this study, we compared first, the kinetics and degree of skin damage in wild-type C57BL/6 mice, and second, tumor treatment efficacy in GL261 and B16F10 dermal tumor models, at the same UHDR-RT and CONV-RT doses. Flank skin
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Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Chengcheng Li,Qiuning Zhang,Hongtao Luo,Ruifeng Liu,Shuangwu Feng,Yichao Geng,Lina Wang,Zhen Yang,Yanying Zhang,Xiaohu Wang
Carbon-ion radiotherapy (CIRT) enhanced local control in patients with malignant melanoma. In several in vitro studies, carbon ions (C ions) have been also shown to decrease the metastatic potential of melanoma cells. CXC motif 10 (CXCL10) has been shown to play a crucial role in regulating tumor metastasis and it significantly increase in human embryonic kidney cells after heavy ion irradiations.
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Loss of Cognitive Flexibility Practice Effects in Female Rats Exposed to Simulated Space Radiation. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Richard A Britten,Arriyam Fesshaye,Alyssa Tidmore,Aiyi Liu,Ashley A Blackwell
During the planned missions to Mars, astronauts will be faced with many potential health hazards including prolonged exposure to space radiation. Ground-based studies have shown that exposure to space radiation impairs the performance of male rats in cognitive flexibility tasks which involve processes that are essential to rapidly and efficiently adapting to different situations. However, there is
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Comparative Analysis of miRNA Expression after Whole-Body Irradiation Across Three Strains of Mice. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Shannon Martello,Michelle A Bylicky,Uma Shankavaram,Jared M May,Sunita Chopra,Mary Sproull,Kevin Mk Scott,Molykutty J Aryankalayil,C Norman Coleman
Whole- or partial-body exposure to ionizing radiation damages major organ systems, leading to dysfunction on both acute and chronic timescales. Radiation medical countermeasures can mitigate acute damages and may delay chronic effects when delivered within days after exposure. However, in the event of widespread radiation exposure, there will inevitably be scarce resources with limited countermeasures
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Mathematical Aspects of a New Synergy Theory Applicable to Malstressor-Dominated Mixtures which Include Damage-Ameliorating Countermeasures. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 R K Sachs,E G Huang,L G Hanin
In radiobiology, and throughout translational biology, synergy theories for multi-component agent mixtures use 1-agent dose-effect relations (DERs) to calculate baseline neither synergy nor antagonism mixture DERs. The most used synergy theory, simple effect additivity, is not self-consistent when curvilinear 1-agent DERs are involved, and many alternatives have been suggested. In this paper we present
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Advances in Polymeric Neutron Shielding: The Role of Benzoxazine-h-BN Nanocomposites in Nuclear Protection. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Slimane Abdous,Mehdi Derradji,Zineb Mekhalif,Karim Khiari,Oussama Mehelli,Younes Bourenane Cherif
Given their substantial neutron capture cross-section, extreme hardness, and high chemical and thermal stability, boron-based materials are widely used as building blocks to protect against highly ionizing radiations such as gamma rays and neutrons. Indeed, uncontrolled nuclear radiation exposure can be highly hazardous to radiation workers and the public. In this sense, this work presents an extensive
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Trends in Radiation Dose to the Contralateral Breast During Breast Cancer Radiation Therapy Radiat. Res. (IF 3.4) Pub Date : 2023-08-16 Gordon P. Watt, Susan A. Smith, Rebecca M. Howell, Angélica Pérez-Andújar, Anne S. Reiner, Laura Cerviño, Beryl McCormick, Daniela Hess, Julia A. Knight, Kathleen E. Malone, Esther M. John, Leslie Bernstein, Charles F. Lynch, Lene Mellemkjær, Roy E. Shore, Xiaolin Liang, Meghan Woods, John D. Boice, Lawrence T. Dauer, Jonine L. Bernstein
Over 4 million survivors of breast cancer live in the United States, 35% of whom were treated before 2009. Approximately half of patients with breast cancer receive radiation therapy, which exposes the untreated contralateral breast to radiation and increases the risk of a subsequent contralateral breast cancer (CBC). Radiation oncology has strived to reduce unwanted radiation dose, but it is unknown
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Connexin26 Modulates Radiation-Induced Skin Damage by Regulating Chemokine CCL27 through MAPK Signaling. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Rui Tao,Yiwen Mao,Yuan Li,Minqiong Sun,Xiaoping Cao,Ni Chen,Shengmin Xu,Dong Wang,Ye Zhao
Connexin26 (Cx26) plays an important role in ionizing radiation-induced damage, and CC chemokine ligand 27 (CCL27) regulates the skin immune response. However, the relationship between Cx26 and CCL27 in radiation-induced skin damage is unclear. After X-ray irradiation, clonogenic survival and micronucleus formation were assessed in immortalized human keratinocytes (HaCaT). Proteins in the mitogen activated
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Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood. Radiat. Res. (IF 3.4) Pub Date : 2023-09-01 Constantinos G Broustas,Sanjay Mukherjee,Igor Shuryak,Alexandra Taraboletti,Jerry Angdisen,Pelagie Ake,Albert J Fornace,Sally A Amundson
High-dose-radiation exposure in a short period of time leads to radiation syndromes characterized by severe acute and delayed organ-specific injury accompanied by elevated organismal morbidity and mortality. Radiation biodosimetry based on gene expression analysis of peripheral blood is a valuable tool to detect exposure to radiation after a radiological/nuclear incident and obtain useful biological
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Multiple Mesh-type Real Human Cell Models for Dosimetric Application Coupled with Monte Carlo Simulations. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 YiDi Wang,Dong Kong,Han Gao,ChuanSheng Du,HuiYuan Xue,Kun Liu,XiangHui Kong,WenYue Zhang,YuChen Yin,Tao Wu,Yang Jiao,Liang Sun
The mesh-type models are superior to voxel models in cellular dose assessment coupled with Monte Carlo codes. The aim of this study was to expand the micron-scale mesh-type models based on the fluorescence tomography of real human cells, and to investigate the feasibility of these models in the application of various irradiation scenarios and Monte Carlo codes. Six different human cell lines, including
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Electron, Photon, and Neutron Dose Conversion Coefficients of Lens and Non-Lens Tissues Using a Multi-Tissue Eye Model to Assess Risk of Cataracts and Retinitis. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 Fawaz Ali,Richard B Richardson
Previous publications describe the estimation of the dose from ionizing radiation to the whole lens or parts of it but have not considered other eye tissues that are implicated in cataract development; this is especially critical for low-dose, low-ionizing-density exposures. A recent review of the biological mechanisms of radiation-induced cataracts showed that lenticular oxidative stress can be increased
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Noncancer Effects of Ionizing Radiation Exposure on the Eye, the Circulatory System and beyond: Developments made since the 2011 ICRP Statement on Tissue Reactions Radiat. Res. (IF 3.4) Pub Date : 2023-07-07 Nobuyuki Hamada
For radiation protection purposes, noncancer effects with a threshold-type dose-response relationship have been classified as tissue reactions (formerly called nonstochastic or deterministic effects), and equivalent dose limits aim to prevent occurrence of such tissue reactions. Accumulating evidence demonstrates increased risks for several late occurring noncancer effects at doses and dose rates much
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Feasibility of Reducing Animal Numbers in Radiation Countermeasure Experiments from Historic Levels when using Sample Size Calculations. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 Reid D Landes,Kimberly J Jurgensen,William K J Skinner,Horace J Spencer,Lynnette Cary
Historically, animal numbers have most often been in the hundreds for experiments designed to estimate the dose reduction factor (DRF) of a radiation countermeasure treatment compared to a control treatment. Before 2010, researchers had to rely on previous experience, both from others and their own, to determine the number of animals needed for a DRF experiment. In 2010, a formal sample size formula
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The Regulation of Exosome-Mediated miR-132-3p/miR-132-3p-UUU on Radiation-Induced Esophageal Injury. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 Muzi Liu,Zhiqiang Sun,Yiting Tang,Shuyu Zhang,Judong Luo
Radiation-induced esophageal injury (RIEI) is a major dose-limiting complication of radiotherapy, mainly acute esophagitis. However, understanding of radiation injury and repair mechanisms in esophageal epithelial cells remains limited. MiR-132-3p and its uridylated isoform (miR-132-3p-UUU) are upregulated in radiation esophageal injury, yet their role in radiation-induced esophageal injury progression
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Formulation of Time-Dependent Cell Survival with Saturable Repairability of Radiation Damage. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 Takeji Sakae,Kenta Takada,Satoshi Kamizawa,Toshiyuki Terunuma,Koichi Ando
This study aims to provide a model that compounds historically proposed ideas regarding cell survival irradiated with X rays or particles. The parameters used in this model have simple meanings and are closely related to cell death-related phenomena. The model is adaptable to a wide range of doses and dose rates and thus can consistently explain previously published cell survival data. The formulas
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TLR4 Agonist MPLA Ameliorates Heavy-Ion Radiation Damage via Regulating DNA Damage Repair and Apoptosis. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 Tingting Liu,Hang Wang,Hui Shen,Zhipeng Du,Zhijie Wan,Junshi Li,Xide Zhang,Zhuqing Li,Nan Yang,Yanyong Yang,Yuanyuan Chen,Fu Gao,Kun Cao
Heavy-ion radiation received during radiotherapy as well as the heavy-ion radiation received during space flight are equally considered harmful. Our previous study showed that TLR4 low toxic agonist, monophosphoryl lipid A (MPLA), alleviated radiation injury resulting from exposure to low-LET radiation. However, the role and mechanism of MPLA in heavy-ion-radiation injury are unclear. This study aimed
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RENEB Inter-Laboratory Comparison 2021: Inter-Assay Comparison of Eight Dosimetry Assays. Radiat. Res. (IF 3.4) Pub Date : 2023-06-01 M Port,J-F Barquinero,D Endesfelder,J Moquet,U Oestreicher,G Terzoudi,F Trompier,A Vral,Y Abe,L Ainsbury,L Alkebsi,S A Amundson,C Badie,A Baeyens,A S Balajee,K Balázs,S Barnard,C Bassinet,L A Beaton-Green,C Beinke,L Bobyk,P Brochard,K Brzoska,M Bucher,B Ciesielski,C Cuceu,M Discher,M C D Oca,I Domínguez,S Doucha-Senf,A Dumitrescu,P N Duy,F Finot,G Garty,S A Ghandhi,E Gregoire,V S T Goh,I Güçlü,L Hadjiiska
Tools for radiation exposure reconstruction are required to support the medical management of radiation victims in radiological or nuclear incidents. Different biological and physical dosimetry assays can be used for various exposure scenarios to estimate the dose of ionizing radiation a person has absorbed. Regular validation of the techniques through inter-laboratory comparisons (ILC) is essential
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Of Men and Mice: Using Terrestrial Radiation Epidemiology Methods to Inform Analysis of Animal Models for Space Radiation Risk Assessment. Radiat. Res. (IF 3.4) Pub Date : 2023-08-01 Lori J Chappell,Katherine M Rahill,S Robin Elgart
Prediction of cancer risk from space radiation exposure is critical to ensure spaceflight crewmembers are adequately informed of the risks they face when accepting assignments to ambitious long-duration exploratory missions. Although epidemiological studies have assessed the effects of exposure to terrestrial radiation, no robust epidemiological studies of humans exposed to space radiation exist to
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Advanced Boron Neutron Capture Therapy Targeting Cancer Stem Cells by Selective Induction of LAT1 Overexpression. Radiat. Res. (IF 3.4) Pub Date : 2023-07-01 Toshiaki Tani,Tomoya Fujita,Masaki Misawa,Naomi Tojo,Naoto Shikano,Minoru Suzuki,Ken Ohnishi
This study conducted fundamental research to develop a more effective BNCT targeting cancer stem cells. We constructed plasmids that induced the overexpression of L-type amino acid transporter 1 (LAT1) tagged with tdTomato on the cytoplasmic membranes of CD133 expressing cancer cells. After transfection of the plasmids into a glioblastoma cell line (T98G), several clones overexpressing LAT1-tdTomato
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Variable Dose Rates in Realistic Radiation Exposures: Effects on Small Molecule Markers of Ionizing Radiation in the Murine Model. Radiat. Res. (IF 3.4) Pub Date : 2023-07-01 Evan L Pannkuk,Evagelia C Laiakis,Guy Garty,Brian Ponnaiya,Xuefeng Wu,Igor Shuryak,Shanaz A Ghandhi,Sally A Amundson,David J Brenner,Albert J Fornace
Novel biodosimetry assays for use in preparedness and response to potential malicious attacks or nuclear accidents would ideally provide accurate dose reconstruction independent of the idiosyncrasies of a complex exposure to ionizing radiation. Complex exposures will consist of dose rates spanning the low dose rates (LDR) to very high-dose rates (VHDR) that need to be tested for assay validation. Here
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Downregulation of β-Catenin Contributes to type II Alveolar Epithelial Stem Cell Resistance to Epithelial-Mesenchymal Transition by Lowing Lin28/let-7 Ratios in Fibrosis-Resistant Mice after Thoracic Irradiation. Radiat. Res. (IF 3.4) Pub Date : 2023-07-01 Dandan Xuan,Chunyan Du,Wendi Zhao,Jianwei Zhou,Shan Dai,Tingting Zhang,Mengge Wu,Jian Tian
Transdifferentiation of type II alveolar cells (AECII) is a major cause for radiation-induced lung fibrosis (RILF). Cell differentiation phenotype is determined by Lin28 (undifferentiated marker) and let-7 (differentiated marker) in a see-saw-pattern. Therefore, differentiation phenotype can be extrapolated based on Lin28/let-7 ratio. Lin28 is activated by β-catenin. To the best of our knowledge this
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The Effect of Prostate-Specific Antigen (PSA) Test on Radiation Risk Estimate for Prostate Cancer Incidence among Atomic-Bomb Survivors. Radiat. Res. (IF 3.4) Pub Date : 2023-07-01 Mai Utada,Alina V Brenner,Dale L Preston,Michiko Yamada,Eric J Grant,Hiromi Sugiyama,Ritsu Sakata,Elizabeth K Cahoon,Kotaro Ozasa,Kiyohiko Mabuchic
Following our previous report on the radiation dose-response for prostate cancer incidence rates in the Life Span Study (LSS) cohort of atomic bomb survivors, we reevaluated the radiation-related risk adjusting for differences in baseline cancer incidence rates among three subsets of the LSS cohort defined by the timing of their first participation in biennial health examinations offered to the Adult
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Joseph L. Roti Roti, PhD (1943-2023). Radiat. Res. (IF 3.4) Pub Date : 2023-07-01 Julie Schwarz,Michael L Freeman
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Genomic Loss and Epigenetic Silencing of the FOSL1 Tumor Suppressor Gene in Radiation-induced Neoplastic Transformation of Human CGL1 Cells Alters the Tumorigenic Phenotype In Vitro and In Vivo. Radiat. Res. (IF 3.4) Pub Date : 2023-07-01 Jake Pirkkanen,Sujeenthar Tharmalingam,Christopher Thome,Helen Chin Sinex,Laura V Benjamin,Adam C Losch,Anthony J Borgmann,Ryan M Dhaemers,Christopher Gordon,Douglas R Boreham,Marc S Mendonca
The CGL1 human hybrid cell system has been utilized for many decades as an excellent cellular tool for investigating neoplastic transformation. Substantial work has been done previously implicating genetic factors related to chromosome 11 to the alteration of tumorigenic phenotype in CGL1 cells. This includes candidate tumor suppressor gene FOSL1, a member of the AP-1 transcription factor complex which