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Dynamic duo: Kir6 and SUR in KATP channel structure and function Channels (IF 3.3) Pub Date : 2024-03-15 Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central...
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Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold Channels (IF 3.3) Pub Date : 2024-03-06 Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding...
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Recent advances on the structure and the function relationships of the TRPV4 ion channel Channels (IF 3.3) Pub Date : 2024-02-14 Raúl Sánchez-Hernández, Miguel Benítez-Angeles, Ana M. Hernández-Vega, Tamara Rosenbaum
The members of the superfamily of Transient Receptor Potential (TRP) ion channels are physiologically important molecules that have been studied for many years and are still being intensively resea...
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A phenylalanine at the extracellular side of Kir1.1 facilitates potassium permeation Channels (IF 3.3) Pub Date : 2024-01-07 Henry Sackin, Mikheil Nanazashvili
The Kir1.1 (ROMK) family of weak inward rectifiers controls K secretion in the renal CCT and K recycling in the renal TALH. A single point mutant of the inward rectifier, F127V-Kir1.1b was used to ...
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Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology Channels (IF 3.3) Pub Date : 2023-12-28 Minas Sakellakis, Sung Mi Yoon, Jashan Reet, Athanasios Chalkias
Preclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regenerat...
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Reducing agents facilitate membrane patch seal integrity and longevity Channels (IF 3.3) Pub Date : 2023-12-28 Damayantee Das, Anson Wong, Timothy N. Friedman, Bradley J Kerr, Harley T. Kurata, Shawn M. Lamothe
The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is requir...
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Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes Channels (IF 3.3) Pub Date : 2023-12-06 Mohammad-Reza Ghovanloo, Sidharth Tyagi, Peng Zhao, Philip R. Effraim, Sulayman D. Dib-Hajj, Stephen G. Waxman
Sexual dimorphism has been reported in multiple pre-clinical and clinical studies on pain. Previous investigations have suggested that in at least some states, rodent dorsal root ganglion (DRG) neu...
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Structural biology of voltage-gated calcium channels Channels (IF 3.3) Pub Date : 2023-12-07 Xia Yao, Shuai Gao, Nieng Yan
Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane depolarization, playing critical roles in diverse physiological processes. Dysfunction or aberrant regulation of Cav...
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A structural atlas of druggable sites on Nav channels Channels (IF 3.3) Pub Date : 2023-11-30 Zhangqiang Li, Qiurong Wu, Nieng Yan
Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological significance, dysfunction, or mutations in thes...
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Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology Channels (IF 3.3) Pub Date : 2023-11-20 William A. Catterall
Voltage-gated sodium channels initiate action potentials in nerve and muscle, and voltage-gated calcium channels couple depolarization of the plasma membrane to intracellular events such as secreti...
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Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models Channels (IF 3.3) Pub Date : 2023-11-20 Jiaqi Bao, Zhicheng Gao, Yilan Hu, Lifang Ye, Lihong Wang
Cardiovascular disease, especially heart failure (HF) is the leading cause of death in patients with diabetes. Individuals with diabetes are prone to a special type of cardiomyopathy called diabeti...
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A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions Channels (IF 3.3) Pub Date : 2023-11-07 Priti Chatterjee, Debaleena Bhowmik, Sib Sankar Roy
Monocarboxylate transporters (MCTs) play an immense role in metabolically active solid tumors by regulating concentration-dependent transport of different important monocarboxylates including pyruv...
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Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels Channels (IF 3.3) Pub Date : 2023-10-31 Zhengshan Hu, Jian Yang
Recent years have seen an outpouring of atomic or near atomic resolution structures of cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially open, and fully op...
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The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment Channels (IF 3.3) Pub Date : 2023-10-31 Yuan Yuan, Zhouhong Xiang, Yuhua Xia, Jiaheng Xie, Xiudi Jiang, Zhicheng Lu
Breast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic character...
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Molecular pharmacology of the onco-TRP channel TRPV6 Channels (IF 3.3) Pub Date : 2023-10-15 Arthur Neuberger, Alexander I. Sobolevsky
TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the gut. Dysregulation of TRPV6 results in disturbed calcium homeostasis leadin...
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Type 3 IP3 receptor: Its structure, functions, and related disease implications Channels (IF 3.3) Pub Date : 2023-10-11 Lvying Wu, Jin Chen
Cell-fate decisions depend on the precise and strict regulation of multiple signaling molecules and transcription factors, especially intracellular Ca2+ homeostasis and dynamics. Type 3 inositol 1,...
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Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses Channels (IF 3.3) Pub Date : 2023-10-08 Simona D Frederiksen, Leigh E Wicki-Stordeur, Leigh Anne Swayne
Many neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neur...
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Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads Channels (IF 3.3) Pub Date : 2023-09-11 K. George Chandy, Karoline Sanches, Raymond S. Norton
ABSTRACT The voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivating mutant of rat KV1.2-KV2.1 paddle chimera (KVChim-W362F+S367T+V377T) reveal that the transition of voltage-gated potassium channels from the open-conducting
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TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism Channels (IF 3.3) Pub Date : 2023-07-31 Matthew Gabrielle, Tibor Rohacs
ABSTRACT TMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be necessary for sensing mechanical pain. TMEM120A’s ion channel function has subsequently been challenged, as attempts to replicate electrophysiological experiments
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Advancements in the study of inward rectifying potassium channels on vascular cells Channels (IF 3.3) Pub Date : 2023-07-18 Chunshu Li, Yan Yang
ABSTRACT Inward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved in maintaining resting membrane potential and signal transduction in most cells, as well as connecting metabolism and membrane excitability of body cells. It is closely related to normal physiological functions of body and the occurrence and development of some diseases. Although the functional
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Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels Channels (IF 3.3) Pub Date : 2023-06-30 Emilio R. Mustafá, Konstantin Weiß, Norbert Weiss
ABSTRACT Missense mutations in the human secretary carrier-associated membrane protein 5 (SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay, epilepsy, and Parkinson’s disease. We recently documented the importance of SCAMP2 in the regulation of T-type calcium channel expression in the plasma membrane. Here, we show that similar to SCAMP2, the co-expression of SCAMP5
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Cycling matters: Sex hormone regulation of vascular potassium channels Channels (IF 3.3) Pub Date : 2023-05-27 Samuel N Baldwin, Thomas A Jepps, Iain A Greenwood
ABSTRACT Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across
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Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels Channels (IF 3.3) Pub Date : 2023-05-17 Abigail García-Morales, Daniel Balleza
ABSTRACT Structural evidence and much experimental data have demonstrated the presence of non-canonical helical substructures (π and 310) in regions of great functional relevance both in TRP as in Kv channels. Through an exhaustive compositional analysis of the sequences underlying these substructures, we find that each of them is associated with characteristic local flexibility profiles, which in
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The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility Channels (IF 3.3) Pub Date : 2023-05-15 Chenyu Zhao, Xi Zhou, Xiaoliu Shi
ABSTRACT The Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel II neurons in enteric nervous system. The small diameter neurons in dorsal root ganglions are the primary sensory neurons of pain conduction
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Identification of SLC2A3 as a prognostic indicator correlated with the NF-κB/EMT axis and immune response in head and neck squamous cell carcinoma Channels (IF 3.3) Pub Date : 2023-05-03 Fangyu Chai, Jingfang Zhang, Tao Fu, Peng Jiang, Yichuan Huang, Lin Wang, Shu Yan, Xudong Yan, Longgang Yu, Zhen Xu, Ruohuang Wang, Bingqing Xu, Xiaoyun Du, Yan Jiang, Jisheng Zhang
ABSTRACT SLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation of SLC2A3 is associated with poor survival and acts as a prognostic marker in a variety of tumors. Unfortunately, the prognostic role of SLC2A3 in head and neck squamous cell carcinoma (HNSC) is less known. In the present study, we analyzed SLC2A3 expression in HNSC and its
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A governance of ion selectivity based on the occupancy of the “beacon” in one- and four-domain calcium and sodium channels Channels (IF 3.3) Pub Date : 2023-04-19 J. David Spafford
ABSTRACT One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion selectivity filter. The HFS+1 site is dubbed a “beacon” for its location at the entryway just above the constricted, minimum radius of the HFS site’s
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Effect of truncation on TRPM7 channel activity Channels (IF 3.3) Pub Date : 2023-04-11 Zhuqing Xie, Nashat Abumaria
ABSTRACT Transient receptor potential melastatin-like 7 (TRPM7) is a key player in various physiological and pathological processes. TRPM7 channel activity is regulated by different factors. The effects of cleavage of different domains on channel activity remain unknown. Here, we constructed several TRPM7 clones and explored the effects of truncating the mouse TRPM7 at different locations on the ion
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Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells Channels (IF 3.3) Pub Date : 2023-03-27 Wenfeng Lin, Jiaqi Xiong, Yefan Jiang, Hao Liu, Jinhui Bian, Juejin Wang, Yongfeng Shao, Buqing Ni
ABSTRACT Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of MFS and to identify a potential effective target for attenuating MFS. KEGG enrichment analysis showed
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Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels Channels (IF 3.3) Pub Date : 2023-03-21 Thomas Heigl, Michael A. Netzer, Lucia Zanetti, Matthias Ganglberger, Monica L. Fernández-Quintero, Alexandra Koschak
ABSTRACT Cav1.4 L-type calcium channels are predominantly expressed at the photoreceptor terminals and in bipolar cells, mediating neurotransmitter release. Mutations in its gene, CACNA1F, can cause congenital stationary night-blindness type 2 (CSNB2). Due to phenotypic variability in CSNB2, characterization of pathological variants is necessary to better determine pathological mechanism at the site
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Bibliometric analysis of recent research on the association between TRPV1 and inflammation Channels (IF 3.3) Pub Date : 2023-03-15 Pan Xu, Ru-Ru Shao, Yuan He
ABSTRACT TRPV1 channel is a sensitive ion channel activated by some noxious stimuli and has been reported to change many physiological functions after its activation. In this paper, we present a scientometric approach to explore the trends of the association between TRPV1 channel and inflammation and our goal is to provide creative directions for future research. The related literature was retrieved
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SLC26A9 in airways and intestine: secretion or absorption? Channels (IF 3.3) Pub Date : 2023-03-03 Karl Kunzelmann, Raquel Centeio, Jiraporn Ousingsawat, Khaoula Talbi, Ursula Seidler, Rainer Schreiber
ABSTRACT SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gained attention because of its modifier role in the gastrointestinal manifestation of cystic fibrosis (CF). SLC26A9 appears to have an impact on the extent
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L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development Channels (IF 3.3) Pub Date : 2023-02-19 Madelyn R. Baker, Andrew S. Lee, Anjali M. Rajadhyaksha
ABSTRACT Recent human genetic studies have linked a variety of genetic variants in the CACNA1C and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not surprising given the work from multiple laboratories using cell and animal models that have established that Cav1.2 and Cav1.3 L-type calcium channels (LTCCs), encoded by CACNA1C and CACNA1D, respectively, play a key role
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The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity Channels (IF 3.3) Pub Date : 2023-02-03 Karen M Page, Vadim M Gumerov, Shehrazade Dahimene, Igor B Zhulin, Annette C Dolphin
ABSTRACT In this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are present in all α2δ proteins. We have also included new data on the key function of these domains with respect to amino acid and gabapentinoid binding to the
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Advances in CaV1.1 gating: New insights into permeation and voltage-sensing mechanisms Channels (IF 3.3) Pub Date : 2023-01-15 Hugo Bibollet, Audra Kramer, Roger A. Bannister, Erick O. Hernández-Ochoa
ABSTRACT The CaV1.1 voltage-gated Ca2+ channel carries L-type Ca2+ current and is the voltage-sensor for excitation-contraction (EC) coupling in skeletal muscle. Significant breakthroughs in the EC coupling field have often been close on the heels of technological advancement. In particular, CaV1.1 was the first voltage-gated Ca2+ channel to be cloned, the first ion channel to have its gating current
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Calmodulin Mutations in Human Disease Channels (IF 3.3) Pub Date : 2023-01-11 John W. Hussey, Worawan B. Limpitikul, Ivy E. Dick
ABSTRACT Calcium ions (Ca2+) are the basis of a unique and potent array of cellular responses. Calmodulin (CaM) is a small but vital protein that is able to rapidly transmit information about changes in Ca2+ concentrations to its regulatory targets. CaM plays a critical role in cellular Ca2+ signaling, and interacts with a myriad of target proteins. Ca2+-dependent modulation by CaM is a major component
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Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve Channels (IF 3.3) Pub Date : 2022-10-14 Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze, Andrea K. Houghton
ABSTRACT As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to rodents produced changes in cardiovascular parameters and respiratory cessation. We sought to determine the mechanism of the in vivo adverse effects by studying
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Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters Channels (IF 3.3) Pub Date : 2022-09-08 Sharon R. Stevens, Matthew N. Rasband
ABSTRACT The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body. These include voltage-gated sodium, potassium, and calcium channels in the nervous system, heart, lungs, and muscle. At these sites, ankyrins recruit ion
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Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels Channels (IF 3.3) Pub Date : 2022-08-26 Aida Calderon-Rivera, Santiago Loya-Lopez, Kimberly Gomez, Rajesh Khanna
ABSTRACT Voltage-gated sodium and calcium channels (VGSCs and VGCCs) play an important role in the modulation of physiologically relevant processes in excitable cells that range from action potential generation to neurotransmission. Once their expression and/or function is altered in disease, specific pharmacological approaches become necessary to mitigate the negative consequences of such dysregulation
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Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers Channels (IF 3.3) Pub Date : 2022-08-10 Thomas W. Comollo, Xinle Zou, Chuangeng Zhang, Divya Kesters, Thomas Hof, Kevin J. Sampson, Robert S. Kass
ABSTRACT The congenital long QT syndrome (LQTS), one of the most common cardiac channelopathies, is characterized by delayed ventricular repolarization underlying prolongation of the QT interval of the surface electrocardiogram. LQTS is caused by mutations in genes coding for cardiac ion channels or ion channel-associated proteins. The major therapeutic approach to LQTS management is beta blocker therapy
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Genetic and cellular characterization of MscS-like putative channels in the filamentous fungus Aspergillus nidulans Channels (IF 3.3) Pub Date : 2022-08-08 Mariangela Dionysopoulou, Nana Yan, Bolin Wang, Christos Pliotas, George Diallinas
ABSTRACT Mechanosensitive ion channels are integral membrane proteins ubiquitously present in bacteria, archaea, and eukarya. They act as molecular sensors of mechanical stress to serve vital functions such as touch, hearing, osmotic pressure, proprioception and balance, while their malfunction is often associated with pathologies. Amongst them, the structurally distinct MscL and MscS channels from
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Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis Channels (IF 3.3) Pub Date : 2022-08-08 Yanjie Xiong, Liru Dong, Yun Bai, Hui Tang, Shuang Li, Dan Luo, Fang Liu, Jie Bai, Shikun Yang, Xudong Song
ABSTRACT Ovarian cancer (OC) is a highly malignant cancer with great metastatic potential. Here we aimed to investigate the role of Piezo1, a gene related to the mechanical environment of the tumor, in promoting the metastasis of OC. We performed Piezo1 knockdown in A-1847 cells using small hairpin RNAs, and the cells were inoculated subcutaneously in nude mice. Piezo1 knockdown decreased the tumor
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Cardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review Channels (IF 3.3) Pub Date : 2022-08-08 Nikolaus Schreiber, Martin Manninger, Sascha Pätzold, Alexander C. Reisinger, Stefan Hatzl, Gerald Hackl, Christoph Högenauer, Philipp Eller
ABSTRACT Ingestion of leaves of the European yew tree (Taxus baccata) can result in fatal cardiac arrhythmias and acute cardiogenic shock. This cardiotoxicity derives from taxine alkaloids that block cardiac voltage-gated sodium and calcium channels. Prompt initiation of venoarterial extracorporeal membrane oxygenation is essential to bridge these critically ill patients to recovery, as there is no
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Non-conducting functions of ion channels: The case of integrin-ion channel complexes Channels (IF 3.3) Pub Date : 2022-08-08 Elena Forzisi, Federico Sesti
ABSTRACT Started as an academic curiosity more than two decades ago, the idea that ion channels can regulate cellular processes in ways that do not depend on their conducting properties (non-ionic functions) gained traction and is now a flourishing area of research. Channels can regulate physiological processes including actin cytoskeletal remodeling, cell motility, excitation-contraction coupling
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Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes Channels (IF 3.3) Pub Date : 2022-06-27 Zhongcheng Liu, Yuchen Tang, Liangzhi He, Bin Geng, Fan Lu, Jinwen He, Qiong Yi, Xuening Liu, Kun Zhang, Lifu Wang, Yayi Xia, Jin Jiang
ABSTRACT Piezo1, a mechanosensitive ion channel, participates in a variety of biological processes in maintaining bone homeostasis. As the most abundant cells in bones of the mammals, osteocytes play an essential role in bone formation, remodeling, and bone mass maintenance. Here, by exposing MLO-Y4 osteocytes to the fluid shear stress (FSS) microenvironment, we explored the effect of Piezo1-mediated
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Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels Channels (IF 3.3) Pub Date : 2022-06-27 Bo Yang, Jia-Lu Yao, Jian-Yi Huo, Yu-Long Feng, William A. Coetzee, Guang-Yin Xu, Hua-Qian Yang
ABSTRACT ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection. However, the molecular mechanisms regulating KATP channel internalization and endocytic recycling, which directly affect the surface expression of KATP channels, are poorly understood
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Hippocampus-related cognitive disorders develop in the absence of epilepsy and ataxia in the heterozygous Cacna1a mutant mice tottering Channels (IF 3.3) Pub Date : 2022-05-12 Akito Nakao, Katsumi Hayashida, Hiroo Ogura, Yasuo Mori, Keiji Imoto
ABSTRACT CACNA1A-associated epilepsy and ataxia frequently accompany cognitive impairments as devastating co-morbidities. However, it is unclear whether the cognitive deficits are consequences secondary to the neurological symptoms elicited by CACNA1A mutations. To address this issue, Cacna1a mutant mice tottering (tg), and in particular tg/+ heterozygotes, serve as a suitable model system, given that
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Mechanism of carvedilol induced action potential and calcium alternans Channels (IF 3.3) Pub Date : 2022-05-02 Elizabeth Martinez-Hernandez, Giedrius Kanaporis, Lothar A. Blatter
ABSTRACT Carvedilol is a nonspecific β-blocker clinically used for the treatment of cardiovascular diseases but has also been shown to have profound effects on excitation-contraction coupling and Ca signaling at the cellular level. We investigate the mechanism by which carvedilol facilitates Ca transient (CaT) and action potential duration (APD) alternans in rabbit atrial myocytes. Carvedilol lowered
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Capsaicin as an amphipathic modulator of NaV1.5 mechanosensitivity Channels (IF 3.3) Pub Date : 2022-04-12 Luke M. Cowan, Peter R. Strege, Radda Rusinova, Olaf S. Andersen, Gianrico Farrugia, Arthur Beyder
ABSTRACT SCN5A-encoded NaV1.5 is a voltage-gated Na+ channel that drives the electrical excitability of cardiac myocytes and contributes to slow waves of the human gastrointestinal smooth muscle cells. NaV1.5 is mechanosensitive: mechanical force modulates several facets of NaV1.5’s voltage-gated function, and some NaV1.5 channelopathies are associated with abnormal NaV1.5 mechanosensitivity (MS).
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Integrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma. Channels (IF 3.3) Pub Date : 2022-12-01 Zixuan Gong,Jiaheng Xie,Liang Chen,Qikai Tang,Yiming Hu,Aiming Xu,Zengjun Wang
The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the expression and prognosis of TRPV family and tumor-infiltrating immune cells in ccRCC are obscure. This study aimed to explore the prognostic and therapeutic
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Integrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma Channels (IF 3.3) Pub Date : 2022-04-07 Zixuan Gong, Jiaheng Xie, Liang Chen, Qikai Tang, Yiming Hu, Aiming Xu, Zengjun Wang
ABSTRACT The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the expression and prognosis of TRPV family and tumor-infiltrating immune cells in ccRCC are obscure. This study aimed to explore the prognostic
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Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V Channels (IF 3.3) Pub Date : 2022-04-04 Xu Dehong, Wu Wenmei, Hong Siqin, Zeng Peng, Wang Xianchun, Zeng Xiongzhi
ABSTRACT JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1.2–1.4. However, the underlying action mechanism of JZTX-V on Kv4.3 remains unclear. In our study, JZTX-V could inhibit not only transient
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AMP-activated protein kinase(AMPK) channel: A Global Bibliometric analysis From 2012 to 2021 Channels (IF 3.3) Pub Date : 2022-03-21 Tianyi Lyu, Chuanxi Tian, Tianyang Tan, Jiaxuan Lyu, Kang Yan, Xirui Zhao, Ruoshui Wang, Chaoyang Zhang, Meng Liu, Yulong Wei
ABSTRACT In recent years, AMPK channel has gained considerable attention in a variety of research areas, and several academic journals have published articles on AMPK research. However, few attempts have been made to thoroughly assess the scientific output and current status systematically in this topic from a worldwide viewpoint. As a result, it is critical to adopt an appropriate visualization method
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Bibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020) Channels (IF 3.3) Pub Date : 2022-03-02 Chuanxi Tian, Xueping Zhu, Qiuyuan Wang, Tianyi Lv, Siyi Cheng, Daowen Yang
(2022). Bibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020) Channels: Vol. 16, No. 1, pp. 49-59.
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Clinical and molecular characteristics of myotonia congenita in China: Case series and a literature review Channels (IF 3.3) Pub Date : 2022-02-16 Yifan Li, Mao Li, Zhenfu Wang, Fei Yang, Hongfen Wang, Xiujuan Bai, Bo Sun, Siyu Chen, Xusheng Huang
ABSTRACT Myotonia congenita (MC) is a rare genetic disease caused by mutations in the skeletal muscle chloride channel gene (CLCN1), encoding the voltage-gated chloride channel ClC-1 in skeletal muscle. Our study reported the clinical and molecular characteristics of six patients with MC and systematically review the literature on Chinese people. We retrospectively analyzed demographics, clinical features
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A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC) Channels (IF 3.3) Pub Date : 2022-02-03 Eric E. Figueroa, Jerod S. Denton
ABSTRACT Newly emerging roles of LRRC8 volume-regulated anion channels (VRAC) raise important questions about the therapeutic potential of VRAC in the treatment of epilepsy, type 2 diabetes, and other human diseases. A critical barrier to evaluating whether VRAC represents a viable drug target is the lack of potent and specific small-molecule inhibitors and activators of the channel. Here we review
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Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats Channels (IF 3.3) Pub Date : 2022-01-05 Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna
ABSTRACT The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However, targeting this channel directly has failed, and an indirect approach – disruption of interactions with accessory protein partners – has emerged as a viable alternative
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Nitrergic modulation of ion channel function in regulating neuronal excitability Channels (IF 3.3) Pub Date : 2021-11-22 Jereme G Spiers, Joern R Steinert
ABSTRACT Nitric oxide (NO) signaling in the brain provides a wide range of functional properties in response to neuronal activity. NO exerts its effects through different signaling pathways, namely, through the canonical soluble guanylyl cyclase-mediated cGMP production route and via post-translational protein modifications. The latter pathways comprise cysteine S-nitrosylation and 3-nitrotyrosination
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PANX1 is a potential prognostic biomarker associated with immune infiltration in pancreatic adenocarcinoma: A pan-cancer analysis Channels (IF 3.3) Pub Date : 2021-11-19 Lingling Bao, Kai Sun, Xuede Zhang
ABSTRACT Pannexin 1 (PANX1) channel is a critical ATP-releasing pathway that modulates tumor immunity, progression, and prognosis. However, the roles of PANX1 in different cancers remain unclear. We analyzed the expression of PANX1 in human pan-cancer in the Oncomine and GEPIA2.0 databases. The prognostic value of PANX1 expression was determined using Kaplan-Meier plotter and OncoLnc tools. The correlation
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Transient Receptor Potential channels: A Global Bibliometric analysis From 2012 to 2021 Channels (IF 3.3) Pub Date : 2021-11-13 Xueping Zhu, Chuanxi Tian, Yan Zhou, Jingjing Shi, Guozhen Yuan, Limei Zhang, Yuchen Jiang, Wenjing Xue, Yihang Du, Yuanhui Hu
(2021). Transient Receptor Potential channels: A Global Bibliometric analysis From 2012 to 2021. Channels: Vol. 15, No. 1, pp. 624-634.
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Regulation of acid-sensing ion channels by protein binding partners Channels (IF 3.3) Pub Date : 2021-10-27 Megan M. Cullinan, Robert C. Klipp, John R. Bankston
ABSTRACT Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels that contribute to a diverse array of functions including pain sensation, cell death during ischemia, and more broadly to neurotransmission in the central nervous system. There is an increasing interest in understanding the physiological regulatory mechanisms of this family of channels. ASICs have relatively short