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Characterisation and optimisation of foams for varicose vein sclerotherapy Biorheology (IF 0.889) Pub Date : 2021-01-13 T.G. Roberts; S.J. Cox; A.L. Lewis; S.A. Jones
BACKGROUND:Foam sclerotherapy is the process of using an aqueous foam to deliver surfactant to a varicose vein to damage vein wall endothelial cells, causing the vein to spasm, collapse and ultimately be re-absorbed into the body. Aqueous foams are complex fluids that can exhibit a significant yield stress and high effective viscosity which depend on their composition, particularly the bubble size
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Viscosity and mixing properties of artificial saliva and four different mouthwashes Biorheology (IF 0.889) Pub Date : 2021-01-13 Stevan Hinic; Bojan Petrovic; Sanja Kojic; Nejra Omerovic; Jovana Jevremov; Nina Jelenciakova; Goran Stojanovic
BACKGROUND:Numerous functions of saliva depend on its biophysical properties. Mouth rinses react with saliva and change both their own properties and properties of saliva. OBJECTIVE:The aim of this study was to define the level of mixing of artificial saliva and mouth rinses, define their viscosityand its changes at room and body temperature. METHODS:Artificial saliva, fluoride solutions, chlorhexidine
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Influence of near-wall PIV data on recirculation hemodynamics in a patient-specific moderate stenosis: Experimental-numerical comparison Biorheology (IF 0.889) Pub Date : 2020-11-12 Neha Sharma; Sudeep Sastry; John M. Sankovic; Jaikrishnan R. Kadambi; Rupak K. Banerjee
BACKGROUND:Recirculation zones within the blood vessels are known to influence the initiation and progression of atherosclerotic lesions. Quantification of recirculation parameters with accuracy remains subjective due to uncertainties in measurement of velocity and derived wall shear stress (WSS).OBJECTIVE:The primary aim is to determine recirculation height and length from PIV experiments while validating
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Usefulness of whole blood viscosity estimated by de Simeone's formula to predict left ventricular thrombus formation within one year following acute anterior myocardial infarction. Biorheology (IF 0.889) Pub Date : 2020-05-20 Ömer Faruk Çırakoğlu,Ahmet Oguz Aslan,Ahmet Seyda Yilmaz,Selim Kul,İhsan Dursun
Background:Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke. Objectives:To evaluate the predictive value of estimated whole blood viscosity(WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction
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Porcine bile viscosity is proportional to density. Biorheology (IF 0.889) Pub Date : 2020-04-21 Nguyen Ngoc Minh,Hiromichi Obara
BACKGROUND:The gallbladder filling and emptying cycle controls bile flow into the duodenum. Disruption of this emptying and refilling cycle leads to bile stasis and subsequent gallstone formation. The bile flow rate is inversely proportional to its viscosity. Moreover, bile is a complex material with varying density in different people because of its diverse components. These density changes alter
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Viscoelastic behavior of cardiomyocytes carrying LMNA mutations. Biorheology (IF 0.889) Pub Date : 2020-02-19 Daniele Borin,Brisa Peña,Matthew R G Taylor,Luisa Mestroni,Romano Lapasin,Orfeo Sbaizero
BACKGROUND:Laminopathies are genetic diseases caused by mutations in the nuclear lamina. OBJECTIVE:Given the clinical impact of laminopathies, understanding mechanical properties of cells bearing lamin mutations will lead to advancement in the treatment of heart failure. METHODS:Atomic force microscopy (AFM) was used to analyze the viscoelastic behavior of neonatal rat ventricular myocyte cells expressing
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Viscoelastic characterization of diabetic and non-diabetic human adipose tissue. Biorheology (IF 0.889) Pub Date : 2020-02-17 Benjamin A Juliar,Clarissa Strieder-Barboza,Monita Karmakar,Carmen G Flesher,Nicki A Baker,Oliver A Varban,Carey N Lumeng,Andrew J Putnam,Robert W O'Rourke
BACKGROUND:Obesity-induced chronic inflammation and fibrosis in adipose tissue contributes to the progression of type 2 diabetes mellitus (DM). While fibrosis is known to induce mechanical stiffening of numerous tissue types, it is unknown whether DM is associated with alterations in adipose tissuemechanical properties. OBJECTIVE:The purpose of this study was to investigate whether DM is associated
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Nitrite may serve as a combination partner and a biomarker for the anti-cancer activity of RRx-001. Biorheology (IF 0.889) Pub Date : 2019-12-26 Selma Cirrik,Elif Ugurel,Ali Cenk Aksu,Bryan Oronsky,Pedro Cabrales,Ozlem Yalcin
BACKGROUND:RRx-001 is an anti-cancer immunotherapeutic that increases the sensitivity of drug resistant tumors via multiple mechanisms which involve binding to hemoglobin and enhancing nitrite reductase activity of deoxyhemoglobin. OBJECTIVE:In the present study, the effect of clinically used dosesof RRx-001 on erythrocyte deformability was examined. METHODS:A dose dependent effect of RRx-001 (1-1000
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Tensile behavior and extensional viscosity of bile. Biorheology (IF 0.889) Pub Date : 2019-12-26 Nguyen Ngoc Minh,Hiromichi Obara,Kenji Shimokasa,Junfang Zhu
BACKGROUND:Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. OBJECTIVE:We investigated the stretching of bile and evaluated its extensional viscosity using a filament-breakup device. METHODS:A liquid bridge formed between the endplates of the filament-breakup
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Correlation of the cell mechanical behavior and quantified cytoskeletal parameters in normal and cancerous breast cell lines. Biorheology (IF 0.889) Pub Date : 2019-12-26 Mohammad Tabatabaei,Mohammad Tafazzoli-Shadpour,Mohammad Mehdi Khani
BACKGROUND:Cancerous transformation of cells affects their mechanical behavior and cytoskeleton structure. OBJECTIVE:The objective of this research is to investigate a correlation between mechanical properties and cytoskeletal structure features in cancer cell formation. METHODS:Micropipette aspiration was used to compare mechanical properties of normal (MCF10A) and cancerous (T47D) epithelial breast
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Relative shedding of glycosaminoglycans from the endothelial glycocalyx during inflammation and their contribution to stiffness of the glycocalyx. Biorheology (IF 0.889) Pub Date : 2019-01-01 Herbert H Lipowsky
BACKGROUND The endothelial (EC) surface layer (glycocalyx) has been shown to act as a barrier to transvascular exchange of solutes, and adhesion of leukocytes (WBCs) during the inflammatory process. It is a labile structure whose components are readily shed by the action of proteases and endoglycosidases. Details of shedding of specific constituents of the glycocalyx remain to be determined. OBJECTIVES
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Endothelial barrier reinforcement relies on flow-regulated glycocalyx, a potential therapeutic target. Biorheology (IF 0.889) Pub Date : 2019-01-01 Ian C Harding,Ronodeep Mitra,Solomon A Mensah,Alina Nersesyan,Nandita N Bal,Eno E Ebong
BACKGROUND The onset of many disease processes depends on the function of the endothelial cell (EC) glycocalyx (GCX) which acts as a flow-dependent barrier to cellular infiltration and molecular transport across the blood vessel wall. OBJECTIVE This review aims to examine these processes with the potential end goal of implementing GCX repair to restore EC barrier function and slow the progression of
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Comparative adhesive and migratory properties of mesenchymal stem cells from different tissues. Biorheology (IF 0.889) Pub Date : 2019-01-01 Asma Alanazi,Hafsa Munir,Mohammed Alassiri,Lewis S C Ward,Helen M McGettrick,Gerard B Nash
BACKGROUND Mesenchymal stem cells (MSC) are used in therapy, often by injection into the blood. OBJECTIVE We aimed to compare the adhesive and migratory properties of MSC from umbilical cords (UCMSC), bone marrow (BMMSC) or trabecular bone (TBMSC), which might influence delivery to injured tissue. METHODS MSC were perfused through glass capillaries coated with matrix proteins, collagen or fibronectin
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Mechanobiology of the abluminal glycocalyx. Biorheology (IF 0.889) Pub Date : 2019-01-01 Peter J Butler,Amit Bhatnagar
BACKGROUND Endothelial cells (ECs) sense the forces from blood flow through the glycocalyx, a carbohydrate rich luminal surface layer decorating most cells, and through forces transmitted through focal adhesions (FAs) on the abluminal side of the cell. OBJECTIVES This perspective paper explores a complementary hypothesis, that glycocalyx molecules on the abluminal side of the EC between the basement
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Numerical investigation of the effects of blood rheology and wall elasticity in abdominal aortic aneurysm under pulsatile flow conditions. Biorheology (IF 0.889) Pub Date : 2019-01-01 Coşkun Bilgi,Kunt Atalık
BACKGROUND Previous studies on aneurysm modeling have focused on the blood rheology and vessel elasticity separately. The combined effects of blood shear thinning properties and wall elasticity need to be revealed. OBJECTIVE To provide insights on how pulsatile hemodynamics vary with blood rheology and vessel elasticity for a developed abdominal aortic aneurysm (AAA). METHOD An Arbitrary Lagrangian-Eulerian
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Rheological properties and efficacy of the formulation of hyaluronic acid with tamarind seed polysaccharide for arthritis. Biorheology (IF 0.889) Pub Date : 2019-01-01 Won Ho Yoon,Keyong Ho Lee
BACKGROUND Tamarind seed polysaccharide (TSP) is used as a texturizing agent and a thickener in food and pharmaceutical products. There are no publications describing the addition of TSP to intra-articular injection formulations for arthritis. OBJECTIVE The purpose of this study was to investigate the rheology and efficacy of the formulation of TSP with hyaluronic acid (HA) as a new material for injection
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Microvascular hemodynamics: System properties1. Biorheology (IF 0.889) Pub Date : 2019-01-01 Axel R Pries
The hemodynamics of the microcirculation reflect system properties of the involved components. The blood itself is a complex suspension of water, small and large molecules and different cell types. Under most conditions, its rheologic properties are dominated by the different behaviour of fluid and cellular compartments. When perfused through small-bore tubes or vessels, the suspension exhibits specific
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Shear-thickening fluids in biologically relevant agents. Biorheology (IF 0.889) Pub Date : 2019-01-01 Peter Kilbride,Marina Vazquez Rull,Adam Townsend,Helen Wilson,John Morris
BACKGROUND The rheology of shear thickening fluids is well characterized for many physical applications, however the literature surrounding biologically or cryobiologically compatible shear thickening fluids is less well understood. OBJECTIVE This study examined fluids consisting of corn-derived hydroxyethyl starch with a variety of sugars and cryoprotectants to characterize their shear-rate viscosity
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The cancer cell glycocalyx proteoglycan Glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis. Biorheology (IF 0.889) Pub Date : 2019-01-01 Heriberto Moran,Limary M Cancel,Mariya A Mayer,Henry Qazi,Lance L Munn,John M Tarbell
BACKGROUND Previous studies have demonstrated that the glycosaminoglycans (GAGs) heparan sulfate (HS) and hyaluronic acid (HA) are mechanosensors for interstitial flow on cancer cells. The proteins that link the GAGs to the cancer cell for mechanotransduction, however, are not known. OBJECTIVE To assess whether the HS proteoglycan core proteins, Glypican-1 and Syndecan-1, or the HA receptor, CD44,
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Endothelial glycocalyx restoration by growth factors in diabetic nephropathy. Biorheology (IF 0.889) Pub Date : 2019-01-01 Sara Desideri,Karen L Onions,Siân L Baker,Monica Gamez,Hesham El Hegni E Hussien,Amy Russell,Simon C Satchell,Rebecca R Foster
The endothelial glycocalyx (eGlx) constitutes the first barrier to protein in all blood vessels. This is particularly noteworthy in the renal glomerulus, an ultrafiltration barrier. Leakage of protein, such as albumin, across glomerular capillaries results in albumin in the urine (albuminuria). This is a hall mark of kidney disease and can reflect loss of blood vessel integrity in microvascular beds
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Endothelial surface glycocalyx (ESG) components and ultra-structure revealed by stochastic optical reconstruction microscopy (STORM). Biorheology (IF 0.889) Pub Date : 2019-01-01 Jie Fan,Yi Sun,Yifan Xia,John M Tarbell,Bingmei M Fu
BACKGROUND In order to play different roles in vascular functions as a mechanosensor to blood flows and as a barrier to transvascular exchange, the endothelial surface glycocalyx (ESG) should have an organized structure. Due to the limitations of optical and electron microscopy, the ultra-structure of ESG has not been revealed until the recent development of super-resolution optical microscopy, STORM
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Blood flow distribution and the endothelial surface layer in the diabetic retina. Biorheology (IF 0.889) Pub Date : 2019-01-01 Norman R Harris,Wendy Leskova,Gaganpreet Kaur,Randa S Eshaq,Patsy R Carter
Diabetic retinopathy is known as a microvascular complication of hyperglycemia, with a breakdown of the blood-retinal barrier, loss of pericytes, formation of microhemorrhages, early decreases in perfusion and areas of ischemia, with the latter speculated to induce the eventual proliferative, angiogenic phase of the disease. Our animal models of diabetic retinopathy demonstrate similar decreases in
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Understanding endothelial glycocalyx function under flow shear stress from a molecular perspective. Biorheology (IF 0.889) Pub Date : 2019-01-01 Xi Zhuo Jiang,Yufang Lu,Kai H Luo,Yiannis Ventikos
BACKGROUND The endothelial glycocalyx plays a pivotal role in regulating blood flow, filtering blood components, sensing and transducing mechanical signals. These functions are intimately related to its dynamics at the molecular level. OBJECTIVE The objective of this research is to establish the relationship between the functions of the endothelial glycocalyx and its dynamics at the molecular level
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The endothelial glycocalyx: Barrier functions versus red cell hemodynamics: A model of steady state ultrafiltration through a bi-layer formed by a porous outer layer and more selective membrane-associated inner layer. Biorheology (IF 0.889) Pub Date : 2019-01-01 FitzRoy E Curry,C Charles Michel
BACKGROUND Ultrastructural investigations of the endothelial glycocalyx reveal a layer adjacent to the cell surface with a structure consistent with the primary ultrafilter of vascular walls. Theory predicts this layer can be no greater than 200-300 nm thick, a result to be reconciled with observations that red cells and large macromolecules are excluded from a region 1 micrometer or more from the
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Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days. Biorheology (IF 0.889) Pub Date : 2018-12-12 Emine Kilic-Toprak,Fatma Unver,Ozgen Kilic-Erkek,Halil Korkmaz,Yasin Ozdemir,Burak Oymak,Alten Oskay,Melek Bor-Kucukatay
BACKGROUND Isokinetic exercise is used to reduce strength imbalance and to enhance performance. OBJECTIVE The aim of this study was to investigate the acute effects of a single bout of eccentric isokinetic exercise on hemorheology (erythrocyte deformability and aggregation), total oxidant/antioxidant status (TOS/TAS) and oxidative stress index (OSI) in active individuals. METHODS The study comprises
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Rheological parameters of saliva in comparison with taste examination. Biorheology (IF 0.889) Pub Date : 2018-12-12 Anna Marcinkowska-Gapińska,Kamila Linkowska-Świdzińska,Teodor Świdziński,Anna Surdacka
BACKGROUND It is generally unknown if taste sensitivity is dependent upon saliva viscosity. The rheological properties of saliva result from many factors and it has been shown to behave as a non-Newtonian fluid whose viscosity decreases with increasing shear rate. Taste sensitivity may be quantitatively assayed by electro-gustometry. OBJECTIVES The aim of this work was to compare saliva rheological
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Characterization of the visco-elastic properties of hyaluronic acid. Biorheology (IF 0.889) Pub Date : 2018-10-16 Beatriz Lázaro,Prudencio Alonso,Andrea Rodriguez,Manuel La Nuez,Florencio Marzo,Julio G Prieto
BACKGROUND Hyaluronic acid (HA) is a polysaccharide present in almost all animal tissues, in which it carries out important biological functions, among them, the protection of the joints by lubricating them and dampening the tension in them. OBJECTIVE This study compares the viscoelastic properties of several commercial preparations of HA, to determine their suitability for use as viscosupplementation
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Biomechanical properties of veins cultured in vitro under elevated internal pressure. Biorheology (IF 0.889) Pub Date : 2018-07-17 Kozaburo Hayashi,Masuya Kurimoto
BACKGROUND The venous response to elevated blood pressure (BP) is of major importance because it is closely related to the etiology of venous diseases and the competency of vein grafts. In vitro culture experiments may provide useful information on the function of vein grafts because it is easier to separate mechanical and hemodynamic effects from other systemic influences compared to in vivo experiments
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Depletion-model-based numerical simulation of the kinetics of red blood cell aggregation under sinusoidal pulsatile flow. Biorheology (IF 0.889) Pub Date : 2018-07-17 Cheong-Ah Lee,Qi Kong,Dong-Guk Paeng
BACKGROUND Previous numerical modeling studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under steady flow. However, information on the cyclic variation in RBC aggregation under pulsatile flow remains lacking. OBJECTIVE RBC aggregation was simulated to investigate the complex interrelationships among the parameters of RBC motion
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Rheological characterization of an in vitro model for salmonid chyme to quantify changes in feed composition. Biorheology (IF 0.889) Pub Date : 2018-04-18 Mark Schumann,Alexander Brinker,Christian Friedrich
BACKGROUND Developments in the production of aquacultural salmonid feeds in the last 20 years have led to extruded diets with extremely low water content and a shift from mainly marine fish based ingredients towards plant content. These changes expose the industry to the vagaries of the highly dynamic plant protein market. Resulting variations in the precise composition of aqua feeds may carry unpredictable
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Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique. Biorheology (IF 0.889) Pub Date : 2018-04-05 Takahiro Sasaki,Junji Seki,Tomoaki Itano,Masako Sugihara-Seki
BACKGROUND In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a
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Recovery time course of erythrocyte deformability following exposure to shear is dependent upon conditioning shear stress. Biorheology (IF 0.889) Pub Date : 2018-03-27 Lennart Kuck,Marijke Grau,Michael J Simmonds
BACKGROUND Red blood cell (RBC) deformability may increase, or decrease, following application of shear stress ("shear conditioning"), depending upon the specific magnitude and duration of exposure. However, the time course of altered RBC deformability following shear remains unresolved. OBJECTIVE We utilised shear conditioning known to increase (10 Pa) or decrease (64 Pa) RBC deformability and subsequently
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Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl:WI) rats. Biorheology (IF 0.889) Pub Date : 2018-03-23 Viktoria Somogyi,Katalin Peto,Adam Deak,Bence Tanczos,Norbert Nemeth
BACKGROUND Age- and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. OBJECTIVE We aimed to investigate the influence of aging and gender on hemorheological parameters in rats. METHODS Coeval
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Remodeling of the arterial wall: Response to restoration of normal blood flow after flow reduction. Biorheology (IF 0.889) Pub Date : 2018-01-30 Kozaburo Hayashi,Daichi Kakoi,Akihisa Makino
BACKGROUND Although many studies have shown that arteries change diameter in response to chronic change in blood flow (BF), keeping wall shear stress (WSS) at physiologically normal levels, relatively little is known about the effects of flow restoration after flow reduction and also the role of vascular smooth muscle (VSM) during such a remodeling process. OBJECTIVE To elucidate the biomechanical
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Articular cartilage response to a sliding load using two different-sized spherical indenters1. Biorheology (IF 0.889) Pub Date : 2018-01-30 Oliver R Schätti,Vera Colombo,Peter A Torzilli,Luigi M Gallo
BACKGROUND Cartilage surface contact geometry influences the deformational behavior and stress distribution throughout the extracellular matrix (ECM) under load. OBJECTIVE To test the correlation between the mechanical and cellular response of articular cartilage when loaded with two different-sized spherical indenters under dynamic reciprocating sliding motion. METHODS Articular cartilage explants
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In vitro measurement of platelet adhesion to intact endothelial cells under low shear conditions. Biorheology (IF 0.889) Pub Date : 2018-01-23 Yuki Ogawa,Takuma Nakahara,Yuma Nishida,Chihiro Kobayashi,Takamichi Hirata,Hideaki Nagano,Suguru Shiratori,Kenjiro Shimano
BACKGROUND Prediction of thrombus formation at intact arterial walls under low shear flow conditions is clinically important particularly for better prognoses of embolisation in cerebral aneurysms. Although a new mathematical model for this purpose is necessary, little quantitative information has been known about platelet adhesion to intact endothelial cells. OBJECTIVE The objective of this study
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Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon. Biorheology (IF 0.889) Pub Date : 2018-01-15 Shang-Jen Yu,James P Buerck,Edgar A O'Rear,Thomas L Whitsett
BACKGROUND Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation. OBJECTIVE To assess possible red cell contributions to post-thrombolytic no-reflow phenomenon. METHODS Blood clots were formed
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Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD). Biorheology (IF 0.889) Pub Date : 2017-12-28 C J Nettle,L Jenkins,D Curtis,N Badiei,K Lewis,P R Williams,D R Daniels
BACKGROUND The rheological properties of sputum may influence lung function and become modified in disease. OBJECTIVE This study aimed to correlate the viscoelastic properties of sputum with clinical data on the severity of disease in patients with chronic obstructive pulmonary disease (COPD). METHODS Sputum samples from COPD patients were investigated using rheology, simple mathematical modelling
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Simultaneous assessment of blood coagulation and hematocrit levels in dielectric blood coagulometry. Biorheology (IF 0.889) Pub Date : 2017-08-12 Yoshihito Hayashi,Marc-Aurèle Brun,Kenzo Machida,Seungmin Lee,Aya Murata,Shinji Omori,Hidetoshi Uchiyama,Yoshinori Inoue,Toshifumi Kudo,Takahiro Toyofuku,Masayuki Nagasawa,Isao Uchimura,Tomomasa Nakamura,Takeshi Muneta
BACKGROUND In a whole blood coagulation test, the concentration of any in vitro diagnostic agent in plasma is dependent on the hematocrit level but its impact on the test result is unknown. OBJECTIVE The aim of this work was to clarify the effects of reagent concentration, particularly Ca2+, and to find a method for hematocrit estimation compatible with the coagulation test. METHODS Whole blood coagulation
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Impact of training volume and intensity on RBC-NOS/NO pathway and endurance capacity. Biorheology (IF 0.889) Pub Date : 2017-07-13 Christina Koliamitra,Bastian Holtkamp,Philipp Zimmer,Wilhelm Bloch,Marijke Grau
BACKGROUND Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear. OBJECTIVE To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity. METHODS 38 healthy male subjects were randomly
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Effect of ovariectomy and Sideritis euboea extract administration on large artery mechanics, morphology, and structure in middle-aged rats. Biorheology (IF 0.889) Pub Date : 2017-03-25 Dimitrios P Sokolis,Constantinos A Dimitriou,Pavlos Lelovas,Nikolaos G Kostomitsopoulos,Ismene A Dontas
BACKGROUND Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of the carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract
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The autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1. Biorheology (IF 0.889) Pub Date : 2017-03-09 Geert W Schmid-Schönbein
Transformation of circulating leukocytes from a dormant into an activated state with changing rheological properties leads to a major shift of their behavior in the microcirculation. Low levels of pseudopod formation or expression of adhesion molecules facilitate relatively free passage through microvessels while activated leukocytes with pseudopods and enhanced levels of adhesion membrane proteins
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Prediction of the level and duration of shear stress exposure that induces subhemolytic damage to erythrocytes. Biorheology (IF 0.889) Pub Date : 2017-02-23 Michael J Simmonds,Herbert J Meiselman
BACKGROUND Current generation mechanical circulatory assist devices are designed to minimize high shears to blood for prolonged durations to avoid hemolysis. However, red blood cells (RBC) demonstrate impaired capacity to deform when exposed to shear stress (SS) well below the "hemolytic threshold". OBJECTIVE We endeavored to identify how changes in the magnitude and duration of SS exposure alter RBC
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Creep compliance rheology with a probe-like cylindrical geometry. Biorheology (IF 0.889) Pub Date : 2017-02-23 Kelly Connelly,Pooria Sharif-Kashani,Matt Farajzadeh,Jean-Pierre Hubschman,H Pirouz Kavehpour
BACKGROUND Rheology experiments have been performed on the vitreous humor, a soft gel that rests inside of the eye, to study its viscoelastic behavior and underlying macromolecular structure. A significant challenge for experimentalists is preserving the macromolecular structure when removing vitreous from in vivo conditions. OBJECTIVE We have developed a novel probe-like rheometer geometry that allows
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Effect of circulating tissue factor on hypercoagulability in type 2 diabetes mellitus studied by rheometry and dielectric blood coagulometry. Biorheology (IF 0.889) Pub Date : 2016-11-20 Isao Uchimura,Makoto Kaibara,Masayuki Nagasawa,Yoshihito Hayashi
BACKGROUND Hypercoagulability in type 2 diabetes mellitus (T2DM) patients increases their risk of cardiovascular diseases. OBJECTIVE The aim of this work was to investigate the hypercoagulation mechanism in T2DM patients in terms of circulating tissue factor (TF). METHODS Whole blood coagulation tests by damped oscillation rheometry and dielectric blood coagulometry (DBCM) were performed. RESULTS The
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Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry. Biorheology (IF 0.889) Pub Date : 2016-11-20 Haoming Lin,Yuanyuan Shen,Xin Chen,Ying Zhu,Yi Zheng,Xinyu Zhang,Yanrong Guo,Tianfu Wang,Siping Chen
BACKGROUND Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established. OBJECTIVE To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to conventional rheometry methods. In addition, to determine if combining these two methods could
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Osteoarthritic synovial fluid and correlations with protein concentration. Biorheology (IF 0.889) Pub Date : 2016-10-22 Anwar Madkhali,Michael Chernos,Samin Fakhraei,Dana Grecov,Ezra Kwok
BACKGROUND Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. The effects of osteoarthritis on the extensional rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE The purpose of this work is to study the extensional rheology of osteoarthritic synovial fluid and to investigate a possible
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Osteoarthritic synovial fluid rheology and correlations with protein concentration. Biorheology (IF 0.889) Pub Date : 2016-10-22 Anwar Madkhali,Michael Chernos,Dana Grecov,Ezra Kwok
BACKGROUND Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE The purpose of this study is to investigate the effects of protein content on synovial
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Biphasic impairment of erythrocyte deformability in response to repeated, short duration exposures of supraphysiological, subhaemolytic shear stress. Biorheology (IF 0.889) Pub Date : 2016-09-24 Antony P McNamee,Geoff D Tansley,Surendran Sabapathy,Michael J Simmonds
INTRODUCTION Despite current generation mechanical assist devices being designed to limit shear stresses and minimise damage to formed elements in blood, severe secondary complications suggestive of impaired rheological functioning are still observed. At present, the precise interactions between the magnitude-duration of shear stress exposure and the deformability of red blood cells (RBC) remain largely
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The effect of acute and short term normobaric hyperoxia on hemorheologic parameters. Biorheology (IF 0.889) Pub Date : 2016-08-29 Pinar Ulker
Backround:Possible toxic effects of hyperoxia have been reported previously. However, the number of studies investigating the influence of hyperoxia on blood cells is limited and there are no data regarding its hemorheological effects. OBJECTIVE The aim of this study was to investigate the effects of acute hyperoxia, performed in human subjects at normal atmospheric pressure, on the rheological properties
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Large artery biomechanical, geometrical, and structural remodeling elicited by long-term propranolol administration in an animal model. Biorheology (IF 0.889) Pub Date : 2016-07-30 Konstantinos M Lampropoulos,Dimitrios P Sokolis
BACKGROUND Limited attention has been paid to the role of beta-adrenergic blocking agents on large artery function/structure, despite being clinically useful for treating many forms of cardiovascular disease. OBJECTIVE To assess long-term consequences of beta-blocker administration on the biomechanical properties, geometry, and histological structure of two major elastic arteries. METHODS Healthy male
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Rheological effects of macromolecular interactions in synovial fluid. Biorheology (IF 0.889) Pub Date : 2016-07-30 L Martin-Alarcon,T A Schmidt
The rheological properties of synovial fluid (SF) are largely attributed to the presence of high molecular weight hyaluronan (HA). However, rheological differences between SF and pure HA solutions suggest that SF proteins actively contribute towards the bulk viscoelasticity of this biological fluid. Due to various experimental challenges involved with the rheometry of low-viscosity biological fluids
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Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline. Biorheology (IF 0.889) Pub Date : 2016-07-30 Mark B Plotnikov,Oleg I Aliev,Alexey V Nosarev,Alexander Y Shamanaev,Anastasia V Sidekhmenova,Yana Anfinogenova,Anna M Anishchenko,Ekaterina V Pushkina
BACKGROUND Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. OBJECTIVE The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment
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Heterogeneous phase fibrinolysis rates by damped oscillation rheometry. Biorheology (IF 0.889) Pub Date : 2016-07-30 Jae-Suk Lee,Makoto Kaibara,Edgar A O'Rear
BACKGROUND Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion in a monolithic structure differs from the physical situation of thrombolytic therapy
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Atrial natriuretic peptide down-regulates neutrophil recruitment on inflamed endothelium by reducing cell deformability and resistance to detachment force. Biorheology (IF 0.889) Pub Date : 2016-07-10 Vasilios A Morikis,Chris Radecke,Yanyan Jiang,Volkmar Heinrich,Fitz-Roy Curry,Scott I Simon
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Optical twisting to monitor the rheology of single cells. Biorheology (IF 0.889) Pub Date : 2016-05-28 Matthieu Robert de Saint Vincent
BACKGROUND Biological cells exhibit complex mechanical properties which determine their responses to applied force. OBJECTIVE We developed an optical method to probe the temporal evolution of power-law rheology of single cells. METHODS The method consisted in applying optically a constant mechanical torque to a birefringent microparticle bound to the cell membrane, and observing dynamics of the particle's
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Deformation and rupture of Dunaliella salina at high shear rates without the use of thickeners. Biorheology (IF 0.889) Pub Date : 2016-03-12 Dimitrios Kokkinos,Haider Dakhil,Andreas Wierschem,Heiko Briesen,André Braun
BACKGROUND High-density cultures require operating below the critical threshold of shear stress, in order to avoid reducing the specific growth rate of the cells. When determining this threshold, direct inspection of the cells in flow provides insight into the conditions of shearing. OBJECTIVE Aim of this study was using a novel rheo-optical setup for the observation of cells in laminar shear flow
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Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hypertension. Biorheology (IF 0.889) Pub Date : 2016-02-19 Yali Wang,Feng Hu,Xiaoyan Mu,Feng Wu,Dechun Yang,Guixiang Zheng,Xiaoning Sun,Kaizheng Gong,Zhengang Zhang
OBJECTIVES Drag-reducing polymers (DRPs) are blood-soluble macromolecules which may increase blood flow and reduce vascular resistance. The purpose of the present study was to observe the effect of DRPs on monocrotaline-induced pulmonary hypertension (PH) in the rat model. METHODS A total of 64 male Wistar rats were randomly divided into four groups: Group I (pulmonary hypertension model + DRP treatment);
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The expression dynamics of mechanosensitive genes in extra-embryonic vasculature after heart starts to beat in chick embryo. Biorheology (IF 0.889) Pub Date : 2016-02-19 Saranya Rajendran,Lakshmikirupa Sundaresan,Krithika Rajendran,Monica Selvaraj,Ravi Gupta,Suvro Chatterjee
BACKGROUND Fluid flow plays an important role in vascular development. However, the detailed mechanisms, particularly the link between flow and modulation of gene expression during vascular development, remain unexplored. In chick embryo, the key events of vascular development from initiation of heart beat to establishment of effective blood flow occur between the stages HH10 and HH13. Therefore, we
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Hemorheological effects of secoisolariciresinol in ovariectomized rats. Biorheology (IF 0.889) Pub Date : 2016-01-13 Mikhail Y Maslov,Tatiana M Plotnikova,Anna M Anishchenko,Oleg I Aliev,Nikolay E Nifantiev,Mark B Plotnikov
BACKGROUND Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor. OBJECTIVE We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-related and/or surgical menopause induced by ovariectomy in rats. METHODS Arterial blood
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