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Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes J. Autoimmun. (IF 12.8) Pub Date : 2024-03-08 Ivan Garcia-Loza, David Perna-Barrull, Eva Aguilera, Lidia Almenara-Fuentes, Laia Gomez-Muñoz, Daniela Greco, Maria Vila, Miriam Salvado, Montserrat Mancera-Arteu, Michael W. Olszowy, Jordi Petriz, Marti Dalmases, Silvia Rodriguez-Vidal, Bruna Barneda-Zahonero, Marta Vives-Pi
Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting cells. In this context, antigen-specific immunotherapies have been developed to arrest autoimmunity, such as phosphatidylserine (PS)-liposomes. However, the role of certain antigen-presenting cells in immunotherapy, particularly human macrophages (Mφ) in T1D remains elusive. The
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Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease J. Autoimmun. (IF 12.8) Pub Date : 2024-03-08 Dehao Zhu, Longfang Chen, Jianfen Meng, Mengyan Wang, Yuning Ma, Xia Chen, Yu Xiao, Da Yi, Hui Shi, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Chengde Yang, Jialin Teng, Jinchao Jia, Qiongyi Hu
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by a cytokine storm. Efficient early diagnosis of AOSD-associated MAS requires a sensitive and specific biomarker. In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels
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Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases J. Autoimmun. (IF 12.8) Pub Date : 2024-03-07 Wei Huang, Tianyu Jin, Wei Zheng, Qiaoqiao Yin, Qiqi Yan, Hongying Pan, Chengan Xu
Previous studies on the relationship between systemic lupus erythematosus (SLE) and autoimmune liver diseases (AILDs) are inconclusive. Therefore, we employed Mendelian randomization (MR) to explore the causal associations between SLE and AILDs. A two-sample MR analysis was performed using summary-level statistics sourced from genome-wide association study (GWAS) datasets. Inverse-variance weighting
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Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation J. Autoimmun. (IF 12.8) Pub Date : 2024-03-06 Keer Wang, Xiaoxiao Hou, Haimei Lu, Ning Han, Meijuan Xie, Anran Xi, Zhenghao Xu
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a disabling and potentially life-threatening complication of SLE. This study aims to investigate whether ectopic CD4 T cells in the choroid plexus mediate NPSLE in mice. Intracerebroventricular (ICV) injection of anti-CD4 antibody effectively depleted CP-resident CD4 T cells and alleviated NPSLE-like symptoms in MRL/lpr mice. Following ICV injection
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CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus J. Autoimmun. (IF 12.8) Pub Date : 2024-03-05 Thandiwe Chavula, Sarah To, Jennifer Smith, Mesias Pedroza, Jena Nimri, Sridevi Devaraj, Scott Wenderfer, Tiphanie P. Vogel, Sandeep K. Agarwal
Understanding the regulation of efferocytosis by myeloid phagocytes is important in identifying novel targets in systemic lupus erythematosus (SLE). Cadherin-11 (CDH11), a cell adhesion molecule, is implicated in inflammatory arthritis and fibrosis and recently been shown to regulate macrophage phagocytosis. The extent and mechanism of this regulation is unknown. Our objective was to examine the extent
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Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement J. Autoimmun. (IF 12.8) Pub Date : 2024-03-04 Carolina Gaudenzi, Tiziana Schioppa, Mauro Passari, Giovanni Zucchi, Laura Tiberio, Yasmin Vahidi, Sara Scutera, Tiziana Musso, Silvano Sozzani, Annalisa Del Prete, Valentina Salvi, Daniela Bosisio
Monocyte-derived dendritic cells (DCs) are key players in the induction of inflammation, autoreactive T cell activation and loss of tolerance in rheumatoid arthritis (RA), but the precise mechanisms underlying their activation remain elusive. Here, we hypothesized that extracellular microRNAs released in RA synovial fluids may represent a novel, physiological stimulus triggering unwanted immune response
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Application of laboratory models for sarcoidosis research J. Autoimmun. (IF 12.8) Pub Date : 2024-03-04 Maneesh Bhargava, Elliott D. Crouser
This manuscript will review the implications and applications of sarcoidosis models towards advancing our understanding of sarcoidosis disease mechanisms, identification of biomarkers, and preclinical testing of novel therapies. Emerging disease models and innovative research tools will also be considered.
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Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis J. Autoimmun. (IF 12.8) Pub Date : 2024-03-01 Simone Fischer, Christa Meisinger, Dennis Freuer
Among the over 80 different autoimmune diseases, psoriasis (PsO), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) are common representatives. Previous studies indicated a potential link with cancer risk, but suffered often from low statistical power. Thus, we aimed to synthesize the evidence and quantify the association to different female-specific cancer sites. The systematic review was
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Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy J. Autoimmun. (IF 12.8) Pub Date : 2024-03-01 Kastriot Kastrati, Nasim Nakhost Lotfi, Marwa G. Tawfik, Ellen Gelpi, Simon Hametner, Romana Höftberger, Fritz Zimprich, Hakan Cetin, Elisabeth Lindeck-Pozza, Peter Maximilian Heil, Hans P. Kiener, Leonhard X. Heinz, Daniel Mrak, Daniel Aletaha, Michael Bonelli, Helga Radner
The significance of muscle biopsy as a diagnostic tool in idiopathic inflammatory myopathies (IIM) remains elusive. We aimed to determine the diagnostic weight that has been given to muscle biopsy in patients with suspected IIM, particularly in terms of clinical diagnosis and therapeutic decisions. In this retrospective multicentric study, we analyzed muscle biopsy results of adult patients with suspected
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Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice J. Autoimmun. (IF 12.8) Pub Date : 2024-02-29 Manna Lin, Liuting Huang, Junxia Huang, Jia Yu, Xue Yang, Ji Yang
Expansion of follicular helper T (Tfh) cells and abnormal glucose metabolism are present in patients with systemic lupus erythematosus (SLE). Pyruvate kinase M2 (PKM2) is one of the key glycolytic enzymes, and the underlying mechanism of PKM2-mediated Tfh cell glycolysis in SLE pathogenesis remains elusive. We analyzed the percentage of Tfh cells and glycolysis in CD4 T cells from SLE patients and
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miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-29 Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Francesco Muratore, Luigi Boiardi, Alberto Cavazza, Alessandra Bisagni, Luca Cimino, Luca De Simone, Angelo Ghidini, Giuseppe Malchiodi, Marc Corbera-Bellalta, Maria Cinta Cid, Alessandro Zerbini, Carlo Salvarani, Stefania Croci
Giant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and
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P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO) J. Autoimmun. (IF 12.8) Pub Date : 2024-02-23 Amandine Charras, Sigrun R. Hofmann, Allison Cox, Felix Schulze, Susanne Russ, Sarah Northey, Xuan Liu, Yongxiang Fang, Sam Haldenby, Hella Hartmann, Alexander G. Bassuk, Ana Carvalho, Francesca Sposito, Lev Grinstein, Angela Rösen-Wolff, Almut Meyer-Bahlburg, Michael W. Beresford, Elke Lainka, Dirk Foell, Helmut Wittkowski, Hermann J. Girschick, Henner Morbach, Steffen Uebe, Ulrike Hüffmeier, Polly
Chronic nonbacterial osteomyelitis (CNO), an autoinflammatory bone disease primarily affecting children, can cause pain, hyperostosis and fractures, affecting quality-of-life and psychomotor development. This study investigated CNO-associated variants in , encoding for the ATP-dependent -membrane K channel P2X7, and their effects on NLRP3 inflammasome assembly.
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mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses J. Autoimmun. (IF 12.8) Pub Date : 2024-02-21 Jet van den Dijssel, Mariël C. Duurland, Veronique AL. Konijn, Laura YL. Kummer, Ruth R. Hagen, Lisan H. Kuijper, Luuk Wieske, Koos PJ. van Dam, Eileen W. Stalman, Maurice Steenhuis, Dionne M. Geerdes, Juk Yee Mok, Angela HM. Kragten, Charlotte Menage, Lianne Koets, Barbera Veldhuisen, Niels JM. Verstegen, C Ellen van der Schoot, Wim JE. van Esch, Geert RAM. D'Haens, Mark Löwenberg, Adriaan G. Volkers
SARS-CoV-2-specific CD8 T cells recognize conserved viral peptides and in the absence of cross-reactive antibodies form an important line of protection against emerging viral variants as they ameliorate disease severity. SARS-CoV-2 mRNA vaccines induce robust spike-specific antibody and T cell responses in healthy individuals, but their effectiveness in patients with chronic immune-mediated inflammatory
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Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype J. Autoimmun. (IF 12.8) Pub Date : 2024-02-19 Katharina Wørzner, Julie Zimmermann, Regitze Buhl, Anna Desoi, Dennis Christensen, Jes Dietrich, Nina Dieu Nhien Tran Nguyen, Thomas Lindenstrøm, Joshua S. Woodworth, Reham Sabah Alhakeem, Steven Yu, Niels Ødum, Rasmus Mortensen, Judith F. Ashouri, Gabriel K. Pedersen
In many autoimmune diseases, autoantigen-specific Th17 cells play a pivotal role in disease pathogenesis. Th17 cells can transdifferentiate into other T cell subsets in inflammatory conditions, however, there have been no attempts to target Th17 cell plasticity using vaccines. We investigated if autoantigen-specific Th17 cells could be specifically targeted using a therapeutic vaccine approach, where
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Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study J. Autoimmun. (IF 12.8) Pub Date : 2024-02-17 Ariela Hoxha, Nicola Perin, Marco Lovisotto, Antonia Calligaro, Teresa Del Ross, Maria Favaro, Marta Tonello, Andrea Doria, Paolo Simioni
Despite anticoagulant therapy, a antiphospholipid syndrome (APS) has a higher rate of recurrent events, which can lead to damage accrual and a negative impact on life quality. : To evaluate the risk factors and APS subsets associated with damage accrual. We conducted a retrospective single-center study. We reviewed the medical records of 282 APS patients, with a median age of 36 (IQR 30–46) years and
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LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation J. Autoimmun. (IF 12.8) Pub Date : 2024-02-17 Rinkesh K. Gupta, Daniela Salgado Figueroa, Kai Fung, Haruka Miki, Jacqueline Miller, Ferhat Ay, Michael Croft
Psoriasis (PS) and atopic dermatitis (AD) are common skin inflammatory diseases characterized by hyper-responsive keratinocytes. Although, some cytokines have been suggested to be specific for each disease, other cytokines might be central to both diseases. Here, we show that Tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, is required for experimental PS, similar to its requirement
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The enigma of sclera-specific autoimmunity in scleritis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-17 Daphne P.C. Vergouwen, Adriaan A. van Beek, Joeri de Hoog, Joke H. de Boer, Leonoor I. Los, Marlies Gijs, Roel J. Erckens, Rob M. Verdijk, Geert W. Haasnoot, Dave L. Roelen, Aniki Rothova, Johan Rönnelid, Josianne C. Ten Berge, Marco W.J. Schreurs
Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands
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T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities J. Autoimmun. (IF 12.8) Pub Date : 2024-02-15 Juexi Yang, Song Zhang, Qixuan Wu, Pu Chen, Yan Dai, Junhao Long, Yan Wu, Yun Lin
Psoriasis, a chronic inflammatory skin condition, is often accompanied by psychiatric comorbidities such as anxiety, depression, suicidal ideation, and other mental disorders. Psychological disorders may also play a role in the development and progression of psoriasis. The intricate interplay between the skin diseases and the psychiatric comorbidities is mediated by the ‘skin-brain axis’. Understanding
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Aberrant B cell receptor signaling in circulating naïve and IgA+ memory B cells from newly-diagnosed autoantibody-positive rheumatoid arthritis patients J. Autoimmun. (IF 12.8) Pub Date : 2024-02-13 Stefan F.H. Neys, Judith W. Heutz, Jennifer A.C. van Hulst, Madelief Vink, Ingrid M. Bergen, Pascal H.P. de Jong, Erik Lubberts, Rudi W. Hendriks, Odilia B.J. Corneth
Altered B cell receptor (BCR) signaling has been implicated in the pathogenesis of rheumatoid arthritis (RA). Here we aimed to identify signaling aberrations in autoantibody-positive and autoantibody-negative RA patients by performing a comprehensive analysis of the BCR signaling cascade in different B cell subsets. We first optimized phosphoflow cytometry for an in-depth analysis of BCR signaling
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Age-related bone diseases: Role of inflammaging J. Autoimmun. (IF 12.8) Pub Date : 2024-02-09 Jiaming Bi, Caimei Zhang, Caihong Lu, Chuzi Mo, Jiawei Zeng, Mingyan Yao, Bo Jia, Zhongjun Liu, Peiyan Yuan, Shuaimei Xu
Bone aging is characterized by an imbalance in the physiological and pathological processes of osteogenesis, osteoclastogenesis, adipogenesis, and chondrogenesis, resulting in exacerbated bone loss and the development of age-related bone diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis, and periodontitis. Inflammaging, a novel concept in the field of aging research, pertains to
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The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial J. Autoimmun. (IF 12.8) Pub Date : 2024-02-07 Roberta Lorenzon, Claire Ribet, Fabien Pitoiset, Selim Aractingi, Beatrice Banneville, Laurent Beaugerie, Francis Berenbaum, Patrice Cacoub, Julien Champey, Olivier Chazouilleres, Christophe Corpechot, Bruno Fautrel, Arsène Mekinian, Elodie Regnier, David Saadoun, Joe-Elie Salem, Jérémie Sellam, Philippe Seksik, Eric Vicaut, Michelle Rosenzwajg, David Klatzmann
A Tregs insufficiency is central to autoimmune and inflammatory diseases pathophysiology and low dose interleukin-2 (IL-2) can specifically activate Tregs. To assess IL-2 therapeutic potential and select diseases for further clinical development, we performed an open-label, phase 2a, disease-finding, “basket trial” involving patients with one of 13 different autoimmune diseases. 81 patients treated
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Phenotypes in antiphospholipid syndrome: A hierarchical cluster analysis based on two independent databases J. Autoimmun. (IF 12.8) Pub Date : 2024-02-07 Dov Taieb, Quentin Moyon, Raphael Lhote, Isabella Annesi-Maesano, Julien Haroche, Ricard Cervera, Zahir Amoura, Fleur Cohen Aubart
Antiphospholipid syndrome (APS) is a rare autoimmune disease characterized by thromboses at various sites and obstetric events associated with the persistent presence of antiphospholipid antibodies. The identification of clinical phenotypes in APS patients is a clinical need. In this study, we aimed to determine the clinical phenotypes of APS patients through an unsupervised analysis of two well-characterized
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IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-01 Hiroki Furuya, Cuong Thach Nguyen, Trevor Chan, Alina I. Marusina, Alexander A. Merleev, Maria de la Luz Garcia-Hernandez, Shie-Liang Hsieh, George C. Tsokos, Christopher T. Ritchlin, Ilias Tagkopoulos, Emanual Maverakis, Iannis E. Adamopoulos
IL-23-activation of IL-17 producing T cells is involved in many rheumatic diseases. Herein, we investigate the role of IL-23 in the activation of myeloid cell subsets that contribute to skin inflammation in mice and man. IL-23 gene transfer in WT, IL-23R reporter mice and subsequent analysis with spectral cytometry show that IL-23 regulates early innate immune events by inducing the expansion of a
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CXCL12-CXCR4 mediates CD57+ CD8+ T cell responses in the progression of type 1 diabetes J. Autoimmun. (IF 12.8) Pub Date : 2024-02-01 Ting Zhong, Xinyu Li, Kang Lei, Rong Tang, Zhiguang Zhou, Bin Zhao, Xia Li
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Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study J. Autoimmun. (IF 12.8) Pub Date : 2024-01-28 Shuai Yuan, Daniel Leffler, Benjamin Lebwohl, Peter H.R. Green, Susanna C. Larsson, Jonas Söderling, Jiangwei Sun, Jonas F. Ludvigsson
Objectives Celiac disease (CeD) has been linked to an increased risk of other autoimmune diseases, yet the impact of delayed CeD diagnosis on risk of developing additional autoimmune diseases remains uncertain. We investigated this through a nationwide matched case-control study. Methods Using the ESPRESSO cohort with histophatology data from Sweden's 28 pathology departments, we assessed 46,575 biopsy-confirmed
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Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis J. Autoimmun. (IF 12.8) Pub Date : 2024-01-31 Rui Wang, Qiuxiang Lin, Zhonghua Lu, Haoyu Wen, Fangqin Hu, Jia You, Yonghong He, Yuan Fang, Zhaolian Bian, Qiuchen Hou, Zhaoxia Ju, Yanyan Wang, Min Lian, Xiao Xiao, Li Sheng, Canjie Guo, Jing Hua, Ruqi Tang, Zhengrui You, Xiaoyu Chen, Xiong Ma
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A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile J. Autoimmun. (IF 12.8) Pub Date : 2024-01-13 Linnea Lindelöf, Solbritt Rantapää-Dahlqvist, Christian Lundtoft, Johanna K. Sandling, Dag Leonard, Ahmed Sayadi, Lars Rönnblom, Helena Enocsson, Christopher Sjöwall, Andreas Jönsen, Anders A. Bengtsson, Mun-Gwan Hong, Lina-Marcela Diaz-Gallo, Matteo Bianchi, Sergey V. Kozyrev, Kerstin Lindblad-Toh, , , Kristina Nilsson Ekdahl, Bo Nilsson, Oskar Eriksson
The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of the lectin pathway of complement in humans, but its role in systemic autoimmune disease has not been conclusively determined. Here, we combined biochemical and genetic approaches to assess the contribution of
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Proximity extension assay proteomics and renal single cell transcriptomics uncover novel urinary biomarkers for active lupus nephritis J. Autoimmun. (IF 12.8) Pub Date : 2024-01-08 Yaxi Li, Chenling Tang, Kamala Vanarsa, Nga Thai, Jessica Castillo, Gabrielle Alexis Braza Lea, Kyung Hyun Lee, Soojin Kim, Claudia Pedroza, Tianfu Wu, Ramesh Saxena, Chi Chiu Mok, Chandra Mohan
Objective To identify urinary biomarkers that can distinguish active renal involvement in Lupus Nephritis (LN), a severe manifestation of systemic lupus erythematosus (SLE). Methods Urine from 117 subjects, comprised of inactive SLE, active non-renal lupus, active LN, and healthy controls, were subjected to Proximity Extension Assay (PEA) based comprehensive proteomics followed by ELISA validation
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Hoigné’s syndrome, an uncommon mimicker of anaphylaxis: Systematic literature review J. Autoimmun. (IF 12.8) Pub Date : 2024-01-08 Danilo Consolascio, Gabriel Bronz, Pietro F. Lardelli, Gregorio P. Milani, Sebastiano A.G. Lava, Benedetta Terziroli Beretta Piccoli, Mario G. Bianchetti, Marcel M. Bergmann, Mattia Rizzi
The term Hoigné’s syndrome denotes a mimicker of anaphylaxis, which occurs immediately after the parenteral administration of a drug and is likely caused by non-thrombotic pulmonary and systemic drug micro-embolization. It has so far been documented uniquely in case reports and small case series. Because this condition has never been systematically evaluated, we performed a structured literature review
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Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis J. Autoimmun. (IF 12.8) Pub Date : 2023-12-30 Xuening Peng, He Li, Lei Zhu, Sichen Zhao, Zhaohuai Li, Si Li, , Jialing Chen, Songguo Zheng, Wenru Su
Autoimmune uveitis (AU) is a severe disorder causing poor vision and blindness. However, the cellular dynamics and pathogenic mechanisms underlying retinal injury in uveitis remain unclear. In this study, single-cell RNA sequencing of the retina and cervical draining lymph nodes in experimental autoimmune uveitis mice was conducted to identify the cellular spatiotemporal dynamics and upregulation of
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Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis J. Autoimmun. (IF 12.8) Pub Date : 2023-12-23 Li Gao, Wei Zhang, Lina Zhang, Barbora Gromova, Guanqing Chen, Eva Csizmadia, Cortney Cagle, Silvia Nastasio, Yun Ma, Alan Bonder, Vilas Patwardhan, Simon C. Robson, Sizun Jiang, Maria Serena Longhi
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Tofacitinib restores psoriatic arthritis fibroblast-like synoviocytes function via autophagy and mitochondrial quality control modulation J. Autoimmun. (IF 12.8) Pub Date : 2023-12-22 Ettore Silvagni, Sonia Missiroli, Simone Patergnani, Caterina Boncompagni, Clotilde D'Ugo, Carlo Garaffoni, Maria Sofia Ciliento, Giovanni Lanza, Massimo Bonora, Roberta Gafà, Mariasole Perrone, Alessandra Bortoluzzi, Carlotta Giorgi, Marcello Govoni, Carlo Alberto Scirè, Paolo Pinton
Objectives To evaluate the in vitro effect of tofacitinib on autophagy activity of psoriatic arthritis (PsA) fibroblast-like synoviocytes (FLS), and to confirm its activity on inflammatory and invasive properties of FLS and synovial cells, deepening the impact on mitochondrial function. Methods FLS, peripheral blood mononuclear cells (PBMCs), and synovial cells from active PsA patients were cultured
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Gene-expression profiling of laser-dissected islets and studies in deficient mice reveal chemokines as differential driving force of type 1 diabetes J. Autoimmun. (IF 12.8) Pub Date : 2023-12-22 Christine Bender, Peter Müller, Camilla Tondello, Jessica Horn, Martin Holdener, Stanley Lasch, Monika Bayer, Josef M. Pfeilschifter, Frank Tacke, Andreas Ludwig, Martin-Leo Hansmann, Claudia Döring, Edith Hintermann, Urs Christen
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High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome J. Autoimmun. (IF 12.8) Pub Date : 2023-12-18 Emiko Desvaux, Patrice Hemon, Perrine Soret, Christelle Le Dantec, Loukas Chatzis, Divi Cornec, Valérie Devauchelle-Pensec
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Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown J. Autoimmun. (IF 12.8) Pub Date : 2023-12-09 Quentin Reuschlé, Laurien Van Heddegem, Victor Bosteels, Matthieu Moncan, Sabine Depauw, Nadège Wadier, Sandra Maréchal, Clint De Nolf, Virginia Delgado, Yosra Messai, Marie-Claude Stolzenberg, Aude Magérus, Angélique Werck, Jérôme Olagne, Quan Li, Guillaume Lefevre, Anne-Sophie Korganow, Frédéric Rieux-Laucat, Sophie Janssens, Pauline Soulas-Sprauel
Anti-nuclear antibodies are the hallmark of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma. However, the molecular mechanisms of B cell tolerance breakdown in these pathological contexts are poorly known. The study of rare familial forms of autoimmune diseases could therefore help to better describe common biological mechanisms leading to B cell tolerance breakdown.
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Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program J. Autoimmun. (IF 12.8) Pub Date : 2023-12-08 Emily C. Somers, Jaclyn M. Goodrich, Lu Wang, Sioban D. Harlow, Wendy Marder, Afton L. Hassett, Suzanna M. Zick, W Joseph McCune, Caroline Gordon, Kamil E. Barbour, Charles G. Helmick, Faith M. Strickland
Background Environmental factors can influence epigenetic regulation, including DNA methylation, potentially contributing to systemic lupus erythematosus (SLE) development and progression. We compared methylation of the B cell costimulatory CD70 gene, in persons with lupus and controls, and characterized associations with age. Results In 297 adults with SLE and 92 controls from the Michigan Lupus Epidemiology
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High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain J. Autoimmun. (IF 12.8) Pub Date : 2023-12-02 Nataliya Slater, Anuradha Sooda, Emily McLeish, Kelly Beer, Anna Brusch, Rakesh Shakya, Christine Bundell, Ian James, Abha Chopra, Frank L. Mastaglia, Merrilee Needham, Jerome D. Coudert
Objectives Inclusion body myositis (IBM) is a progressive inflammatory-degenerative muscle disease of older individuals, with some patients producing anti-cytosolic 5′-nucleotidase 1A (NT5C1A, aka cN1A) antibodies. Human Leukocyte Antigens (HLA) is the highest genetic risk factor for developing IBM. In this study, we aimed to further define the contribution of HLA alleles to IBM and the production
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Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2023-12-01 Hélène Greigert, André Ramon, Coraline Genet, Claudie Cladière, Claire Gerard, Marion Cuidad, Marc Corbera-Bellalta, Roser Alba-Rovira, Louis Arnould, Catherine Creuzot-Garcher, Laurent Martin, Georges Tarris, Thibault Ghesquière, Sethi Ouandji, Sylvain Audia, Maria C. Cid, Bernard Bonnotte, Maxime Samson
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) through their capacity to produce chemokines recruiting T cells and monocytes in the arterial wall and their ability to migrate and proliferate in the neointima where they acquire a myofibroblast (MF) phenotype, leading to vascular stenosis. This study aimed to investigate if MFs could
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AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions J. Autoimmun. (IF 12.8) Pub Date : 2023-11-25 Keisuke Yasuda, Shieri Shimodan, Natsumi Maehara, Aika Hirota, Ruka Iijima, Akemi Nishijima, Haruka Mori, Ran Toyama, Atsumi Ito, Yuri Yoshikawa, Satoko Arai, Toru Miyazaki
The hallmark of autoimmune arthritis is the preceding autoantibody production and the following synovial inflammation with hyperplasia and tissue destruction of the joints. The joint inflammation is mediated not only by effector lymphocytes and auto-antibodies but also chronic activation of innate immunity, particularly promoted by the danger-associated molecular patterns (DAMPs). Here we show that
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2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-14 Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Dörner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Background Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints and produces pain, swelling, and stiffness. It has a lifetime prevalence of up to 1% worldwide. An extract of Tripterygium wilfordii Hook F (TwHF), a member of the Celastraceae herbal family widely available in south China, has been used for treatment of RA since 1960s. Methods The current consensus practice
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Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4+ T cells in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Elio G. Carmona, José Luis Callejas-Rubio, Enrique Raya, Raquel Ríos-Fernández, Gonzalo Villanueva-Martín, María C. Cid, José Hernández-Rodríguez, Esteban Ballestar, Bernd Timmermann, Norberto Ortego-Centeno, Javier Martín, Ana Márquez
Giant cell arteritis (GCA) is a systemic vasculitis mediated by an aberrant immunological response against the blood vessel wall. Although the pathogenic mechanisms that drive GCA have not yet been elucidated, there is strong evidence that CD4+ T cells are key drivers of the inflammatory process occurring in this vasculitis. The aim of this study was to further delineate the role of CD4+ T cells in
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Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Shane Kelly, Katherine JL. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Background PR3 autoantibodies are essential to the diagnosis and monitoring of granulomatosus with polyangiitis, but to date no PR3 autoantibody sequences have been published. Objectives To identify and characterise PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. Methods Peripheral blood mononuclear cells from seven patients with PR3 autoantibodies were stained with
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Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19 J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. McCoy, Irene M. Ong, Miriam A. Shelef
Rheumatoid factors (RFs), polyreactive antibodies canonically known to bind two conformational epitopes of IgG Fc, are a hallmark of rheumatoid arthritis but also can arise in other inflammatory conditions and infections. Also, infections may contribute to the development of rheumatoid arthritis and other autoimmune diseases. Recently, RFs only in rheumatoid arthritis were found to bind novel linear
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Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Johanne Liberatore, Yann Nguyen, Jérôme Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puéchal, Loïc Guillevin, Benjamin Terrier
Objectives B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) is a risk factor for hypogammaglobulinemia. Aggregating data on gammaglobulin levels kinetics during RTX and its association with the risk of relapse and severe infection is of interest. Methods Gammaglobulin levels were collected before induction therapy and during RTX maintenance therapy. We used different
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Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-08 Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Sander W. Tas
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a long-term, peripheral B cell depletion, but allows for the survival of long-lived plasma cells. Therefore, there is an unmet need for more reversible and full B lineage cell targeting
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Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum J. Autoimmun. (IF 12.8) Pub Date : 2023-11-07 Joshua A. Reynolds, Yaxi Li, Leal Herlitz, Chandra Mohan, Chaim Putterman
Objectives The difficulty of monitoring organ-specific pathology in systemic lupus erythematosus (SLE) often complicates disease prognostication and treatment. Improved non-invasive biomarkers of active organ pathology, particularly lupus nephritis, would improve patient care. We sought to validate and apply a novel strategy to generate the first comprehensive serum proteome of a lupus mouse model
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Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus J. Autoimmun. (IF 12.8) Pub Date : 2023-11-06 Chuqiao Xu, Tianyu Zhang, Hailun Wang, Lin Zhu, Yue Ruan, Zixuan Huang, Jingying Wang, Haiqin Zhu, Chuanxin Huang, Meng Pan
Pemphigus, an autoimmune bullous disease affecting the skin and mucosal membranes, is primarily driven by anti-desmoglein (Dsg) autoantibodies. However, the underlying immune mechanisms of this disease remain largely elusive. Here, we compile an unbiased atlas of immune cells in pemphigus cutaneous lesions at single-cell resolution. We reveal clonally expanded antibody-secreting cells (ASCs) that exhibit
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K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies J. Autoimmun. (IF 12.8) Pub Date : 2023-11-05 Christopher Nelke, Thomas Müntefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preuße, Alexander P.E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Tobias Ruck
K2P2.1 (TREK1), a two-pore domain potassium channel, has emerged as regulator of leukocyte transmigration into the central nervous system. In the context of skeletal muscle, immune cell infiltration constitutes the pathogenic hallmark of idiopathic inflammatory myopathies (IIMs). However, the underlying mechanisms remain to be elucidated. In this study, we investigated the role of K2P2.1 in the autoimmune
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Lung transplantation in pulmonary sarcoidosis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-03 Jin Sun Kim, Rohit Gupta
Sarcoidosis is a systemic inflammatory disease of unknown etiology and variable clinical course. Pulmonary sarcoidosis is the most common presentation and accounts for most morbidity and mortality related to sarcoidosis. While sarcoidosis generally has good outcomes, few patients experience chronic disease. A minority of patients progress to a specific phenotype of sarcoidosis referred to advanced
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Pathogenicity of functionally activated PD-1+CD8+ cells and counterattacks by muscular PD-L1 through IFNγ in myositis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-04 Hirokazu Sasaki, Natsuka Umezawa, Takuji Itakura, Hideyuki Iwai, Shinsuke Yasuda
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Genetic predisposition to sarcoidosis J. Autoimmun. (IF 12.8) Pub Date : 2023-10-19 Shu-Yi Liao, Tasha Fingerlin, Lisa Maier
Sarcoidosis is a complex systemic disease with clinical heterogeneity based on varying phenotypes and natural history. The detailed etiology of sarcoidosis remains unknown, but genetic predisposition as well as environmental exposures play a significant role in disease pathogenesis. We performed a comprehensive review of germline genetic (DNA) and transcriptomic (RNA) studies of sarcoidosis, including
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Pulmonary sarcoidosis: A comprehensive review: Past to present J. Autoimmun. (IF 12.8) Pub Date : 2023-10-19 John A. Belperio, Michael C. Fishbein, Fereidoun Abtin, Jessica Channick, Shailesh A. Balasubramanian, Joseph P. Lynch III
Sarcoidosis is a sterile non-necrotizing granulomatous disease without known causes that can involve multiple organs with a predilection for the lung and thoracic lymph nodes. Worldwide it is estimated to affect 2–160/100,000 people and has a mortality rate over 5 years of approximately 7%. For sarcoidosis patients, the cause of death is due to sarcoid in 60% of the cases, of which up to 80% are from
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Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome J. Autoimmun. (IF 12.8) Pub Date : 2023-10-18 Jelle R. Miedema, Lieke J. de Jong, Denise van Uden, Ingrid M. Bergen, Mirjam Kool, Caroline E. Broos, Vivienne Kahlmann, Marlies S. Wijsenbeek, Rudi W. Hendriks, Odilia B.J. Corneth
Rationale Disease course in sarcoidosis is highly variable. Bronchoalveolar lavage fluid and mediastinal lymph nodes show accumulation of activated T cells with a T-helper (Th)17.1 signature, which correlates with non-resolving sarcoidosis. We hypothesize that the peripheral blood (PB) T cell phenotype may correlate with outcome. Objectives To compare frequencies, phenotypes and function of circulating
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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease J. Autoimmun. (IF 12.8) Pub Date : 2023-10-14 Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-ni Fu, Derek VanDyke, Peter G. Traber, Jamie B. Spangler, Sheldon S. Leung, Petr O. Ilyinskii
Interleukin-2 (IL-2) therapies targeting the high affinity IL-2 receptor expressed on regulatory T cells (Tregs) have shown promising therapeutic benefit in autoimmune diseases through nonselective expansion of pre-existing Treg populations, but are potentially limited by the inability to induce antigen-specific Tregs, as well as by dose-limiting activation of effector immune cells in settings of inflammation
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Cognition following chimeric antigen receptor T-cell therapy: A systematic review J. Autoimmun. (IF 12.8) Pub Date : 2023-10-12 Christina Kazzi, Valeriya Kuznetsova, Pakeeran Siriratnam, Sarah Griffith, Shu Wong, Constantine S. Tam, Rubina Alpitsis, Andrew Spencer, Terence J. O'Brien, Charles B. Malpas, Mastura Monif
Background This systematic review aimed to characterise the cognitive outcomes of patients who received chimeric antigen receptor T-cell therapy. Methods A systematic search of the literature was performed using PubMed, PsycINFO, SCOPUS, EMBASE, Medline, and CINAHL (February 2023). Risk of bias was assessed using the JBI Checklist for Case Reports and the Risk of Bias Assessment Tool for Non-randomised
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Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients J. Autoimmun. (IF 12.8) Pub Date : 2023-10-10 Christa Lichtensteiger, Maximilian Koblischke, Fiamma Berner, Ann-Kristin Jochum, Tobias Sinnberg, Beatrice Balciunaite, Mette-Triin Purde, Vincent Walter, Marie-Therese Abdou, Kathrin Hofmeister, Philipp Kohler, Pietro Vernazza, Werner C. Albrich, Christian R. Kahlert, Alexander Zoufaly, Marianna T. Traugott, Lukas Kern, Urs Pietsch, Gian-Reto Kleger, Miodrag Filipovic, Lukas Flatz
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Quality of life in sarcoidosis J. Autoimmun. (IF 12.8) Pub Date : 2023-10-08 Catharina C. Moor, Ogugua Ndili Obi, Vivienne Kahlmann, Katharina Buschulte, Marlies S. Wijsenbeek
Having sarcoidosis often has a major impact on quality of life of patients and their families. Improving quality of life is prioritized as most important treatment aim by many patients with sarcoidosis, but current evidence and treatment options are limited. In this narrative review, we describe the impact of sarcoidosis on various aspects of daily life, evaluate determinants of health-related quality
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Autoimmune pancreatitis type 2 (idiopathic duct-centric pancreatitis): A comprehensive review J. Autoimmun. (IF 12.8) Pub Date : 2023-10-10 Yang Li, Hanyi Song, Xiangzhen Meng, Runzhuo Li, Patrick S.C. Leung, M. Eric Gershwin, Shucheng Zhang, Siyu Sun, Junmin Song
Autoimmune pancreatitis (AIP) is an uncommon fibro-inflammatory disorder precipitated by autoimmune/inflammatory reactions. Currently, there are two clinical subtypes of AIP (type 1 [AIP-1] and type 2 [AIP-2]) that correspond to two histologic descriptors (lymphoplasmacytic sclerosing pancreatitis and idiopathic duct-centric pancreatitis, respectively). While our understanding of AIP-1 has evolved
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Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights J. Autoimmun. (IF 12.8) Pub Date : 2023-10-08 Elizabeth V. Arkema, Marios Rossides, Yvette C. Cozier
Several epidemiological studies show a co-occurrence of sarcoidosis with other immune-mediated diseases (IMD). There are many similarities between sarcoidosis and IMDs in their geographical distribution and risk factors. Understanding these similarities and identifying the differences can help us to better understand sarcoidosis and put it into context with other IMDs. In this review, we present the