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Notch signaling pathway-based classification of bladder cancer in relation to tumor immune infiltration Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2024-02-19 Yang Bin, Li Guikang, Huang Jin, Zhang Xue, Wang Ruihan, Zhang Jianchao
Introduction: The role of the Notch signaling pathway in the development of various tumors has received increasing attention, but the relationship between the Notch signaling pathway and the prognosis of bladder cancer has rarely been studied. The aim of this study was to investigate the function and risk evaluation value of Notch signaling pathway-related genes (NRGs) in bladder cancer. Material and
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Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2024-02-19 Jingjing Liu, Yingying Xu, Shijie Cheng, Chenfang Wang, Zhengyu Zhang
Diabetic nephropathy (DN) is a major complication of diabetes. Interleukin-1 receptor-associated kinase 2 (IRAK2) has been implicated in various diseases. This study aimed to investigate the role of IRAK2 in DN progression and its association with inflammation and the nuclear factor-kappa B (NF-κB) signaling pathway. DN model mice were generated by intraperitoneal injection of streptozotocin. IRAK2
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Influence of blood sample storage and different types of anticoagulants on results of NK cytotoxicity tests Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2024-01-15 Katarzyna Popko, Monika Paskudzka, Małgorzata Pieśniewska, Sylwia Dąbrowska, Urszula Demkow, Anna Stelmaszczyk-Emmel
Introduction: Natural killer (NK) cells are important players in the human immune response. Impaired NK function may lead to serious, life-threatening conditions. Defects may be consequences of genetic mutations or results of secondary factors such as infections, malignancies and autoimmune diseases. The cytotoxicity test is very useful, but its accessibility is limited to special immunological laboratories
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COVID-19 vaccination in healthcare workers: Long-term benefits and protection Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2024-01-10 Joanna Szczepanek, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Andrzej Tretyn
Introduction: This study aimed to evaluate the long-term effectiveness of COVID-19 vaccination in healthcare workers by analyzing the population’s response to the vaccine after two years, based on anti-SARS-CoV-2 protein S antibody levels. Additionally, the study aimed to assess the impact of basic factors on antibody levels. Material and methods: A total of 4,090 healthcare workers were included in
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Efficacy of IL-23 inhibitors and IL-12/23 inhibitors in the induction treatment of Crohn’s disease: A meta-analysis based on randomized controlled trials Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2024-01-09 Boyang Gao, Haojie Shentu, Suyong Sha, Dongying Wang, Xi Chen, Zhenwei Huang, Nan Dong, Haijia Lai, Jianying Xu, Xiaoshuai Zhou
Introduction: A growing number of randomized controlled trials (RCTs) have demonstrated the effectiveness of interleukin (IL)-23 and IL-12/23 inhibitors in treating Crohn’s disease (CD). This study evaluated the efficacy of IL-23 and IL-12/23 inhibitors in the induction phase for the treatment of CD. Material and methods: We searched the following databases from inception until December, 2022: Medline
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The pathogenesis and regulatory role of HIF-1 in rheumatoid arthritis Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2024-01-08 Han Li, Qi-Yang Wu, Xu-Heng Teng, Zhi-Peng Li, Meng-Ting Zhu, Chao-Jie Gu, Ben-Jia Chen, Qi-Qi Xie, Xin-Jing Luo
Rheumatoid arthritis (RA) is a prevalent autoimmune disease that involves the overgrowth and inflammation of synovial tissue, leading to the degeneration and impairment of joints. In recent years, numerous studies have shown a close relationship between the hypoxic microenvironment in joints and the occurrence and progression of RA. The main cause of the pathological changes in RA is widely believed
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Hematopoietic stem cell transplantation in a patient with activated phosphoinositide 3‑kinase δ syndrome: A case report and literature review Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-12-21 Mateusz P. Łyżwa, Karolina Kędziora, Natalia Kałamarz, Jowita Frączkiewicz, Anna Panasiuk, Joanna Owoc-Lempach, Barbara Piątosa, Marcin Hennig, Ninela Irga-Jaworska, Krzysztof Kałwak
Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described disease characterized by recurrent infections, lymphoproliferation with a high risk of malignancy, early-onset cytopenia, and a propensity for autoimmune diseases. Hematopoietic stem cell transplantation (HSCT) has proven to be an effective treatment method; however, the recovery process after HSCT is prolonged and accompanied
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The role of inflammatory and remodelling biomarkers in patients with non-small cell lung cancer Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-12-13 Hemn Abdalla Omer, Christer Janson, Kawa Amin
Introduction: Biomarkers play a crucial role in evaluating the prognosis, diagnosis, and monitoring of non-small cell lung cancer (NSCLC). The aim of this study was to compare the levels of inflammatory and remodelling biomarkers among patients with NSCLC and healthy controls (HCs) and to investigate the correlation between these biomarkers. Material and methods: Blood samples were taken from 93 NSCLC
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Association of human leukocyte antigen class II alleles with epithelial cell apoptosis and extracellular matrix production in acute COVID-19 Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-12-12 Ieva Vanaga, Oksana Kolesova, Aleksandrs Kolesovs, Gunta Sture, Elvira Hagina, Jelena Storozenko, Liene Nikitina-Zake, Ludmila Viksna
Introduction: Pathogenic mechanisms and long-term consequences of COVID-19 require attention in studies on SARS-CoV-2. The association of the severity of COVID-19 with genetic factors, such as human leukocyte antigen (HLA) genes, remains underexplored. Our study assessed the relationships between HLA class II alleles and COVID-19 severity and blood-based indicators of systemic inflammation and organ
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Newly diagnosed seropositive rheumatoid arthritis in a 52-year-old man superimposed on long-standing ankylosing spondylitis during secukinumab treatment Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-10-13 Jaroslaw Nowakowski, Anna Tomoń, Dorota Telesińska-Jasiówka, Mariusz Korkosz
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are severe chronic inflammatory joint diseases with different immune-mediated mechanisms playing a role in their pathogenesis. Rheumatoid arthritis is an erosive arthritis of peripheral joints and AS is a spondyloarthropathy affecting mainly sacroiliac and spinal joints leading to excessive bone formation and ankylosis. The coexistence of RA
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Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-29 Xiaobo Wang, Lei Ren, Linhan Ye, Jing Cao
Colorectal cancer is one of the most frequently diagnosed cancers. Immunotherapy has been proven to be a potential treatment option for colorectal cancer. Colorectal cancer maintains immune escape by expressing low immunogenicity and following the tolerogenic cell death pathway. There is also emerging evidence that oxaliplatin and photodynamic therapy (PDT) can promote anti-tumor immunity. However
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A biomarker and molecular mechanism investigation for thyroid cancer Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-29 Keju Xie
Introduction: This study aimed to reveal the potential molecular mechanism associated with thyroid cancer (THCA) prognosis, and investigate promising biomarkers for THCA. Material and methods: Differentially expressed genes (DEGs) were compared between THCA samples (THCA group) and normal samples (N group). Then, enrichment analysis and protein-protein interaction (PPI) network analysis were performed
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Downregulation of HMGB1 in thymoma cells affects T cell differentiation Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-29 Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang
Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma tissues and peripheral blood. High mobility group box 1 (HMGB1) is an inflammatory mediator and participates in the pathogenesis of various autoimmune
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The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-29 Katarzyna Samelska, Magdalena Kupis, Katarzyna Szymanek, Justyna Izdebska, Anna Zaleska-Żmijewska, Piotr Skopiński
Limbal epithelial stem cells (LSC, LESC) are multipotent cells used as regenerative treatment of the cornea in patients with limbal epithelial stem cell deficiency (LSCD, LESCD). There are different types of stem cell grafting including cultivated limbal epithelial transplantation (CET) and simple limbal epithelial transplantation (SLET). The outcomes of the techniques have been assessed as similar
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Novel inflammatory markers in patients with severe COVID-19 and a pulmonary thrombotic event Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-21 Jarosław Bakiera, Karolina Strzelec-Pawełczak, Katarzyna Czarnek, Ida Osuchowska-Grochowska, Jacek Bogucki, Agnieszka Markiewicz-Gospodarek, Aleksandra Górska, Zuzanna Chilimoniuk, Sebastian Radej, Mateusz Szymański, Piero Portincasa, Cezary Grochowski
Venous thromboembolism (VTE), clinically manifested as deep vein thrombosis (DVT) or acute pulmonary embolism (PE), is the third most common acute cardiovascular syndrome following myocardial infarction and stroke. The annual incidence of PE is between 39 and 115 per 100,000 inhabitants. The incidence of VTE is almost eight times higher in people aged 80 and older than in the fifth decade of life.
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Anticitrullinated antibodies recognize rheumatoid arthritis associated T-cell epitopes modified by bacterial L-asparaginase Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-21 Tsvetelina Batsalova, Ivanka Teneva, Krum Bardarov, Dzhemal Moten, Balik Dzhambazov
Citrullinated proteins and anti-citrullinated protein antibodies (ACPAs) play an important role in the pathogenesis of rheumatoid arthritis (RA). It has been suggested that during inflammation or dysbiosis, bacteria could initiate production of ACPAs. Most patients with RA are seropositive for ACPAs, but these antibodies have overlapping reactivity to different posttranslational modifications (PTMs)
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Exposure duration of ambient fine particulate matter determines the polarization of macrophages Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-19 Xiangru Li, Hongyan Cai, Wei Wu, Shaoyan Si, Minli Zhu
Ambient fine particulate matter (FPM) promotes airway inflammation and aggravates respiratory and cardiovascular diseases. Macrophage polarization plays an essential role in FPM-induced inflammation and tissue repair. The balance of pro-inflammatory M1-type and anti-inflammatory M2-type macrophages determines the fate of tissues and is involved in the pathogenesis of various FPM-induced diseases. The
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Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-05 Ildikó Tar, Márta Szegedi, Ewa Krasuska-Sławińska, Edyta Heropolitańska-Pliszka, Ewa A. Bernatowska, Elif Öncü, Sevgi Keles, Sukru N. Guner, Ismail Reisli, Nevena Gesheva, Elissaveta Naumova, Lydie Izakovicova-Holla, Jiri Litzman, Igor Savchak, Larysa Kostyuchenko, Melinda Erdős
Autosomal dominant hyper-IgE syndrome (AD-HIES) is an inborn error of immunity (IEI) caused by a dominant-negative mutation in the signal transducer and activator of transcription 3 (STAT 3). This disease is characterized by chronic eczematoid dermatitis, recurrent staphylococcal skin abscesses, pneumonia, pneumatoceles, and extremely high serum IgE levels. Loss-of-function STAT3 mutations may also
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Chronic active Epstein-Barr virus infection as the basis of neoplasm development. Transformation of chronic lymphocytic leukaemia to NK-cell lymphoma/leukaemia was observed by flow cytometry – a diagnostic report Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-09-04 Katarzyna Karwicka, Olga Jankowska-Łęcka, Marek Hus
The case report presents a patient with chronic lymphocytic leukaemia that was diagnosed in 2006 in Rotterdam, the Netherlands. In September 2010, the patient was admitted to the Department of Haematology in Poland due to progression of the underlying disease. The clinical problem during treatment was the suspicion of Richter’s transformation into another, more aggressive non-Hodgkin lymphoma. The
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Severe complications of nivolumab monotherapy in an adolescent with malignant melanoma Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-08-30 Aleksandra Grzegorczyk, Zuzanna Marczyńska, Rafał Matkowski, Marcin Ziętek, Wojciech Pietras, Elżbieta Latos-Grażyńska, Krzysztof Kałwak, Iwona Dachowska-Kałwak
This study presents a case of a 17-year-old female patient who had previously undergone surgical resection of melanoma in the right periscapular area. She was administered adjuvant treatment with the PD-1 inhibitor nivolumab as monotherapy. The mechanism of action of this drug is based on increased stimulation of the immune system. The patient developed a series of complications including capillary
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The role of murine M1 macrophages from different sources in unilateral ureteral obstruction Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-07-20 Xinyu Cui, Yaowen Hu, Genhong Zhang, Li Zhao, Tong Ye, Qingyan Zhang, Jing Liu, Chunming Jiang, Wei Zhu
Introduction: The unilateral ureteral obstruction (UUO) model is the most extensively used model to investigate chronic renal fibrosis. Macrophages play a critical role in the UUO model. We aimed to analyze the phenotype of macrophages from different sources activated in vitro and explore the role of M1 macrophages from various sources in UUO. Material and methods: C57BL/6 mice were randomly allocated
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Prognostic value and immunological role of PTPN21 in pan-cancer analysis Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-07-20 Yane Yang, WenChao Yang, Xingxing Su, CaiXia Cheng
Introduction: At present, cancer remains a persistent public health challenge facing the whole world. Studies have found that PTPN21 is associated with the development of cancer. However, the prognostic potential of PTPN21 in pan-cancer remains unclear. In this work, we aimed to analyze the expression and prognostic value of PTPN21 in pan-cancer and to further study the relationship between PTPN21
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An unusual cause of rapidly progressive glomerulonephritis associated with ANCA vasculitis and ovarian malignancy – a relapse 39 years after initial treatment Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-07-18 Nikola Simovic, Petar Djuric, Jelena Stojsic, Nada Dimkovic, Radomir Naumovic
A 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly progressive renal failure. She was admitted to the nephrology department due to severe deterioration of renal function with complaints of malaise, fever, dry cough and occasional epistaxis that appeared 2 months prior to admission. Histopathologic examination of a specimen from kidney biopsy and immunologic
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Phenotypical changes of hematopoietic stem and progenitor cells in COVID-19 patients: Correlation with disease status Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-07-17 Hosni A. M. Hussein, Ali A. A. Thabet, Taha I. A. Mohamed, Mohamed E. Elnosary, Ali Sobhy, Ahmed M. El-Adly, Ahmed A. Wardany, Elsayed K. Bakhiet, Magdy M. Afifi, Usama M. Abdulraouf, Samah . M. Fathy, Noha G. Sayed, Asmaa M. Zahran
Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) play a crucial role in the context of viral infections and their associated diseases. The link between HSCs and HPCs and disease status in COVID-19 patients is largely unknown. This study aimed to monitor the kinetics and contributions of HSCs and HPCs in severe and non-severe COVID-19 patients and to evaluate their diagnostic
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Effects of theophylline combined with inhaled corticosteroids on patients with moderate and severe asthma and changes of T lymphocyte subsets in peripheral blood Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-06-30 Xiaozhen Cai, Rong Rong, Yidan Huang, Xiaowen Pu, Nanhai Ge
Introduction: Asthma is a common respiratory disease. Theophylline combined with inhaled corticosteroids (ICS) is a promising therapy for asthma. This study explored the therapeutic effects of ICS combined with theophylline on moderate and severe asthma patients and T lymphocyte subsets (CD3+CD8+ T cells) in peripheral blood. Material and methods: A total of 202 moderate and severe asthma patients
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A rare cause of steroid-resistant nephrotic syndrome – a case report Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-06-30 Paulina Kuran, Emilia Platos, Małgorzata Mizerska-Wasiak, Małgorzata Pańczyk-Tomaszewska
Steroid resistance is a common condition occurring in children with nephrotic syndrome. Until now, over 50 genes involved in steroid-resistant nephrotic syndrome (SRNS) pathogenesis have been identified, among which the most prevalent are NPHS1, NPHS2, CD2AP, and PTPRO. The patterns of inheritance of SRNS are autosomal recessive, autosomal dominant, or mitochondrial, and tissues of those patients show
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Efficacy evaluation of direct antiviral drugs against hepatitis B virus in improving the degree of liver fibrosis Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-06-01 Liang Miao, Lihua Cao, Guiqiang Wang
Introduction: The aim of the study was to find an ideal index reflecting inflammation and fibrosis for patients after antiviral treatment, and compare it with imaging examination (liver stiffness measurement – LSM) and traditional liver fibrosis models (APRI and FIB-4). Material and methods: A total of 77 chronic hepatitis B (CHB) patients who achieved a sustained virological response (SVR) after entecavir
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Immunological mechanisms of arterial damage in pediatric patients with primary hypertension Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-05-27 Adam Bujanowicz, Piotr Skrzypczyk
Primary hypertension is a disease that is being diagnosed with increasing frequency in pediatric patients, and many of them are found to have hypertension-mediated organ damage (HMOD), including arterial damage. The pathophysiology of primary hypertension and the formation of HMOD is multifactorial. One mechanism studied in recent years is the subclinical inflammation accompanying the elevation of
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Abnormal expression of CXCL13, MIF and IL-35 in patients with primary Sjögren’s syndrome and its relationship with disease severity Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-05-25 Ronghua Wang, Yushu Yang, Xuying Liu, Lingyan Lei, Xuan Qi
Introduction: The aim of the study was to detect the saliva chemokine (C-X-C motif) ligand 13 (CXCL13), macrophage migration inhibitory factor (MIF), and interleukin 35 (IL-35) levels in patients with primary Sjögren’s syndrome (pSS) and pSS-associated interstitial lung disease (pSS-ILD), and to explore the relationship between CXCL13, MIF, IL-35 levels, and disease severity. Material and methods:
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Prognostic values of regulatory T cells (Tregs) and Treg-related genes in gastric cancer Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-04-20 Liang Zheng, Luping Lin, Jintian Song, Sha Huang, Lizhu Chen, Hui Li, Ning Ma, Qingyue Chen, Yigui Chen
Introduction: This study attempted to investigate the potential of a risk model constructed for regulatory T cells (Tregs) and their related genes in predicting gastric cancer (GC) prognosis. Material and methods: We used flow cytometry to detect the content of CD4+CD25+ Tregs. After detecting expression of five Treg-related genes by quantitative real-time polymerase chain reaction (qRT-PCR), Pearson
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Immunotherapy of B cell lymphoma with CD22-redirected CAR NK-92 cells Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-04-14 Xiaopeng Tian, Ruixi Zhang, Huimin Qin, Xiangru Shi, Wenhui Qi, Dongpeng Jiang, Tingting Zhu, Aining Sun
Introduction: Chimeric antigen receptor (CAR)-NK cells are considered safer than CAR-T cells due to their short lifetime and production of lower toxicity cytokines. By virtue of unlimited proliferative ability in vitro, NK-92 cells could be utilized as the source for CAR-engineered NK cells. CD22 is highly expressed in B cell lymphoma. The goal of our study was to determine whether CD22 could become
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The role of monocytes in malaria infection Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-04-13 Keh Min Xuan, Nurhidanatasha Abu Bakar, Khairul Mohd Fadzli Mustaffa, Maryam Azlan
Malaria remains one of the most common human infections worldwide. In endemic areas, malaria is a leading cause of morbidity and mortality and it imposes significant socioeconomic burdens on the people affected. Monocytes are part of the immune system controlling parasite burden and protecting the host against malaria infection. Monocytes play their protective roles against malaria via phagocytosis
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HMBOX1, a member of the homeobox family: current research progress Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-04-12 Yu Jiang, Hongli Mu, Hengli Zhao
Homeobox containing 1 (HMBOX1) is a transcription factor that was identified in 2006 from a cDNA library of the human pancreas. It belongs to the HNF gene class of the homeobox family. HMBOX1 is widely expressed in normal human tissues; however, its expression level is rather uneven. Homeobox members have been widely reported to participate in embryonic development and differentiation as well as in
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The persistence of SARS-CoV-2 neutralizing antibodies after COVID-19: A one-year observation. Is a SARS-CoV-2 vaccination booster dose necessary? Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-03-28 Adam Tworek, Krzysztof Jaroń, Małgorzata Cicha, Andrzej Rydzewski, Waldemar Wierzba, Artur Zaczyński, Zbigniew Król, Grażyna Rydzewska
Introduction: The aim of this study was to investigate the persistence of SARS-CoV-2 neutralizing antibodies (NAbs) one year after contracting COVID-19. Material and methods: The study included 38 patients – 34 men and 4 women – suffering from COVID-19 between March 15 and May 26, 2020. The median age in the group was 31 years, ranging from 22 to 67 years. The levels of neutralizing antibodies were
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Trigeminal neuralgia occurring after the third dose of Pfizer BioNTech COVID-19 vaccine. Complication or coincidence? An illustrative case report and literature review Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-02-27 Kacper Chrostowski, Michał Piasecki, Joanna Bielewicz
The coronavirus disease 2019 pandemic is an ongoing concern for medical care worldwide. Since its emergence, multiple COVID-19 vaccines have been designed, allowing for more effective control of the pandemic. COVID-19 vaccines, like any other form of medical intervention, may cause adverse and unforeseen side effects, varying in frequency and severity. Determining a correlation between the occurring
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Manifestation of severe congenital neutropenia in the oral cavity. Case report Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-02-24 Ewa Krasuska-Sławińska, Maja Klaudel-Dreszler, Marta Minota, Magdalena Pożyczka-Fedor, Dorota Olczak-Kowalczyk, Izabela Minko-Chojnowska
Severe congenital neutropenia (SCN) comprises a heterogenous group of disorders characterized by a constantly low absolute neutrophil count (ANC) below 0.5 × 109/l in the peripheral blood and maturation arrest of the myelopoiesis in the bone marrow at the promyelocyte/myelocyte stage that lead to early onset of severe bacterial infections in affected patients. Clinical symptoms of congenital neutropenia
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Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy – one-center preliminary study Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-02-23 Tomasz Koszutski, Łukasz Mielańczyk, Grażyna Kucharska, Natalia Matysiak, Agnieszka Wiernik, Grzegorz Kudela, Lidia Hyla-Klekot
Introduction: Juvenile systemic lupus erythematosus (jSLE) is an autoimmune disease that develops as a result of multi-level immune dysregulation, including the interferon pathway. Nephropathy develops at an early stage and eventually affects 90% of patients. A renal biopsy allows one to classify lupus nephritis and determine the proper treatment. Biopsy assessment should be done not only in a light
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The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-02-23 Ljiljana Božić, Darija Knežević, Maja Travar, Nataša Miljuš, Miroslav Petković, Jela Aćimović, Jelena Djaković Dević, Miloš P. Stojiljković, Dejan Bokonjić, Ranko Škrbić
Introduction: During the last two and a half years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread around the world. Most of the SARS-CoV-2 vaccines are designed to produce anti-SARS-CoV-2 immunoglobulin G (IgG) against the viral S-glycoprotein. The aim of this study was to measure the anti-S antibody titres among the medical personnel who had been fully vaccinated
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Molecular regulatory mechanism of LILRB4 in the immune response Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-02-23 Haiyin Liu, Jun Yang, Jing Zhang, Peiyue Zhang, Mengting Zhang, Chaojun Yang, Li Liu, Cuiyuan Huang, Wei Wang, Yuhong Zhai, Jian Yang
Immune diseases are caused by the imbalance of immune regulation. This imbalance is regulated by many factors, both negative and positive. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a member of leukocyte immunoglobulin-like receptors (LILRs). LILRs are expressed constitutively on the surface of multiple immune cells which associate with membrane adaptors to signal through multi- ple cytoplasmic
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Interleukin 35: protective role and mechanism in type 1 diabetes Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-02-14 Si-Ming Zhang, Jun Liang, Ji-Ping Xia, Li Li, Li Zheng, Ya-Lan Wang, Yan-Hong Li, Yan Li, Yu Lu
Interleukin 35 (IL-35), a cytokine secreted by regulatory T (Treg) cells from the differentiation of conventional CD4+ T cells, is a member of the IL-12 family. The IL-12 family of cytokines exhibits an anti-inflammatory property. IL-35 has recently been shown to influence the immune modulation in various diseases, including inflammatory bowel disease, Graves’ disease, rheumatoid arthritis, colitis
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The absence of early malignant changes in women subjected to Aquafilling breast augmentation on the basis of E-cadherin and N-cadherin immunohistochemical expression Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Michał Chalcarz, Jakub Żurawski
The use of Aquafilling can be associated with a variety of health complications. The filler is an inflammatory process trigger at the site of tissue contact. The aim of this study was to semiquantitatively compare the immunohistochemical expression of E-cadherin and N-cadherin in tissue material from two groups of patients. The first group underwent surgical removal of Aquafilling from the breast,
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Evaluation of immunological abnormalities in patients with rare syndromes Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Yahya Gul, Hasan Kapakli, Selma Erol Aytekin, Şukru Nail Guner, Sevgi Keles, Ayşe Gül Zamani, Mahmut Selman Yildirim, Ïsmail Reisli
Introduction: Recurrent infections are important problems in syndromic patients. This study aimed to evaluate immunological abnormalities in patients who presented with recurrent infections and were diagnosed with rare syndromes. Material and methods: This retrospective analysis included 14 patients with complaints of recurrent infections, all of whom were diagnosed with a rare syndrome. Results: The
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ELF3-induced miR-182 inhibits adipogenic differentiation in Graves’ orbitopathy by targeting thyrotropin receptor Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Sha Wang, Lu Chen, Bei Xu
Introduction: Graves’ orbitopathy (GO) is a common autoimmune disease, but its specific pathogenesis has not been fully elucidated. MicroRNAs (miRNAs) possess an important regulatory function in the occurrence and development of autoimmune diseases. In the present study, we explored the potential role of miR-182 in the diagnosis of GO. Material and methods: The expression of miR-182, thyrotropin receptor
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AgNOR patterns and configurations in adult acute leukemia patients Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Małgorzata Gajewska, Iwona Kwiecień, Elżbieta Rutkowska, Piotr Rzepecki, Kazimierz Sułek
The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation
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Implementation of TREC/KREC detection protocol for newborn SCID screening in Bulgaria: a pilot study Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Marina Marinova, Atanaska Georgyeva, Viktoriya Yordanova, Nedelcho Ivanov, Valentina Atanasova, Elissaveta Naumova, Snezhina Mihailova Kandilarova
Neonatal screening for inborn errors of immunity (IEI), based on quantification of T-cell-receptor- excision circles (TRECs) and kappa-deleting recombination-excision circles (KRECs) from dried blood spots (DBS), allows early diagnosis and improved outcomes for the affected children. Determination of TREC/KREC levels from prospectively collected newborns’ Guthrie cards and from DBS samples of patients
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Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Spaska Lesichkova, Snezhina Mihailova, Elisaveta Naumova, Petya Yankova, Yana Krasteva, Ralitsa Marinova
The association of immunocompromised patients and severity of COVID-19 infection is not well established. According to the Centers for Disease Control and Prevention (CDC), primary immune deficiencies (PIDs) are among the conditions that can predispose to a more severe course of COVID-19. We report the clinical course and immunological evaluation of five patients with common variable immune deficiency
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Interleukin 25 and its biological features and function in intestinal diseases Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Wei Jiang, Zehui Wang, Jun Zhang, Minghui Li
Interleukin 25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and an important regulator of the type 2 immune response. Accumulating evidence suggests that IL-25 interacts with diverse immune as well as non-immune cells and plays a rather complicated role in different backgrounds of multiple organs. IL-25 has been studied in the physiology and pathology of the intestine to
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The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-31 Yahui Wang, Ying Chu, Fenghua Cao, Zhihong Chen, Huaxi Xu, Shengjun Wang, Jie Ma
Triggering receptor expressed on myeloid cell-2 (TRE M2) is a transmembrane receptor which is specifically expressed on myeloid cells. To date, TRE M2 has been confirmed as a key factor in many pathologies, such as Alzheimer’s disease, obesity-related metabolic syndrome, fatty liver and atherosclerosis. However, the role of TRE M2 in tumors remains poorly understood. TRE M2 is highly expressed in more
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The analysis of Fe-dependent serum enzymes in severe COVID-19 with a pulmonary thrombotic event Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-13 Jarosław Bakiera, Cezary Grochowski, Karolina Strzelec-Pawełczak, Ida Osuchowska-Grochowska, Mateusz Szymański, Aleksander Michalski, Kinga Kulczycka, Katarzyna Czarnek, Jacek Bogucki, Eliza Blicharska
Introduction: COVID-19 patients in critical condition requiring ICU admission are more likely to experience thromboembolic complications, especially pulmonary embolism. Since the outbreak of coronavirus disease 2019 (COVID-19), clinicians have struggled with the attempt to diagnose and manage the severe and fatal complications of COVID-19 appropriately. Several reports have described significant procoagulatory
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β2-microglobulin alters the profiles of inflammatory cytokines and of matrix metalloprotease in macrophages derived from the osteoarthritic synovium Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2023-01-13 Kyoko Muneshige, Kentaro Uchida, Jun Aikawa, Dai Iwase, Shotaro Takano, Masayuki Miyagi, Gen Inoue, Masashi Takaso
Several studies have implicated b2-microglobulin (B2M) in osteoarthritis (OA) pathology. Of the main constituents of synovial tissue, synovial fibroblasts and macrophages, the latter play a pivotal role in inflammation. Although several studies have investigated the effects of B2M on synovial fibroblasts, few have examined the impact on synovial macrophages. Here, we investigated the effect of B2M
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Characterization of 5-inflammatory-gene signature to affect the immune status and predict prognosis in breast cancer Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-11-16 Hongyan Zang, Gaofeng Ni, Liguo Gong
Introduction Breast cancer (BC) is associated with an inflammatory microenvironment. In BC, epidemiological evidence suggests that inflammation is associated with a poor prognosis. However, approaches to determine the extent of inflammation in the tumor microenvironment remain unclear. Material and methods We downloaded the expression profiles and corresponding clinicopathological information of 1050
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Constructing a thyroid cancer prognostic risk model based on CD8+ T cell associated genes Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-11-16 Yaojie Hu, Xin Guo, Hong Chen, Qing Chang, Haodong Lu, Yanbing Li, Chunyou Chen
Thyroid cancer (TC) is a common and curable endocrine tumor occurring in the head and neck characterized by a low mortality rate compared to other malignancies. In this study, the immune microenvironment of TC was investigated to identify biomarkers. The mRNA and clinical data available in this study were accessed from The Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA) dataset. Differences in immune
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Immune cell-specific smoking-related expression characteristics are revealed by re-analysis of transcriptomes from the CEDAR cohort Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-11-16 Jan Nowak, Emilia Dybska, Alex Adams, Jaroslaw Walkowiak
Introduction Smoking is known to affect whole-blood expression and methylation profiles. Although whole-genome methylation studies indicated that effects observed in blood may be driven by changes within leukocyte subtypes, these phenomena have not been explored using expression profiling. Material and methods This study reanalyzed data from the Correlated Expression and Disease Association Research
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Primary hypertrophic osteoarthropathy – a rare cause of pain and arthritis in children. Description of 5 cases Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-11-16 Joanna Wójtowicz, Beata Kołodziejczyk, Agnieszka Gazda, Piotr Gietka
Primary hypertrophic osteoarthropathy (PHOA) is a very rare disease. The typical triad of symptoms, i.e. digital clubbing, periosteal bone formation with bone and joint deformities and skin hypertrophy, may be accompanied by other specific conditions. In the majority of patients, the picture of the disease is incomplete. The dominant clinical symptom may be osteoarticular complaints. Moreover, the
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Could veterinarians be immune to contracting SARS-CoV-2? Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-10-04 Monika Anna Kozłowska-Geller, Piotr Lewitowicz, Aneta Węgierek-Ciuk, Wioletta Adamus Białek, Agnieszka Piechowska, Stanisław Zbigniew Głuszek
Introduction The aim of the study was to assess the epidemic situation among veterinarians of the Świętokrzyskie Voivodeship, Poland, in relation to the control group. Material and methods The research was divided into 3 stages. Stage I involved the selection of subjects. In stage II, flow cytometry for immunophenotyping was performed and the percentage of the sub-population of CD4 cells and CD8 cells
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Identification of key biomarkers and signaling pathways and analysis of their association with immune cells in immunoglobulin A nephropathy Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-09-29 Guoxin Zhang, Lanfen Xue, Shanshan Zhang, Na Liu, Xing Yao, Jieqiong Fu, Limin Nie
Introduction Immunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide, with a poor prognosis. The aim of our study was to identify key biomarkers and their associations with immune cells to aid in the study of IgAN pathology and immunotherapy. Material and methods The data of IgAN were downloaded from a public database. The metaMA package and limma package were used to identify
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Toll-like receptor (TLR2, TLR4) polymorphisms and their influence on the incidence of urinary tract infections in children with and without urinary tract malformation Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-09-21 Anna Krakowska, Maciej Cedzyński, Agnieszka Wosiak, Rafal Swiechowski, Adrian Krygier, Marcin Tkaczyk, Krzysztof Zeman
Introduction Toll-like receptors (TLRs) contribute to the innate immune system. They are an element of non-specific immunity, which enables organisms to react quickly to foreign antigens, without being previously exposed to them. TLRs are pattern recognition receptors. TLR gene polymorphisms are widely investigated in connection with various infections. The aims of the study were: to investigate the
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Rapamycin relieves lupus nephritis by regulating TIM-3 and CD4+CD25+Foxp3+ Treg cells in an MRL/lpr mouse model Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-09-15 Yan-fang Gao, Xiu-zhao Fan, Rong-shan Li, Xiao-shuang Zhou
Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus (SLE) and is an important driver of morbidity and mortality in SLE. Treg cells and TIM-3 play an important role in the pathogenesis of LN. The beneficial effect of rapamycin on LN has been confirmed in both mouse models and patients, but the effect of rapamycin on Treg cells and TIM-3 is not yet completely understood. In this
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Ischemic stroke as a rare complication of wasp venom allergy: two clinical scenarios Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-09-06 Marita Nittner-Marszalska, Konstanty Guranski, Joanna Bladowska, Agnieszka Kopeć, Maria Ejma
Neurological complications after a single Hymenoptera insect sting are very rare. The authors of this paper describe two instances of cerebral ischemic stroke that occurred immediately after a wasp sting. Two distinct pathomechanisms involved in the cases are put forward. When diagnosing such cases, it is vital to rule out the possibility of an immunoglobulin E (IgE)-dependent reaction of hypersensitivity
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Humoral immune response to COVID-19 infection or vaccination among celiac disease patients Cent. Eur. J. Immunol. (IF 1.3) Pub Date : 2022-08-17 Eman Albatayneh, Yasmeen Alabdallat, Eman Kreishan, Hanin Ayash, Mohammad Abu-Lubad
Introduction Celiac disease (CD) is the most common autoimmune disease (AD) of the small intestine, affecting 1-2% of the population globally. It is characterized by the serological presence of autoantibodies (Abs), tissue transglutaminase antibody (tTGA), immunoglobulin (Ig) A, and IgG. Production of antibodies against SARS-CoV-2 after infection with the virus or vaccination is not well understood