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Melatonin improves salivary gland damage and hypofunction in pSS by inhibiting IL-6/STAT3 signaling through its receptor-dependent manner Mol. Immunol. (IF 3.6) Pub Date : 2024-03-10 Yi Liu, Fang Wang, Bo Cheng, Gang Zhou
Primary Sjogren's syndrome (pSS) is an autoimmune disease of the exocrine glands with no specific or efficient treatments. Melatonin, a natural hormone, is revealed to show multiple biological functions, both receptor-dependent and independent effects, including anti-apoptotic, antioxidant, and anti-inflammatory activities. However, the potential mechanism by which melatonin protects salivary glands
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Recent advances in potential targets for myocardial ischemia reperfusion injury: Role of macrophages Mol. Immunol. (IF 3.6) Pub Date : 2024-03-05 Qigang Zhuang, Mingyue Li, Desheng Hu, Junyi Li
Myocardial ischemia-reperfusion injury (MIRI) is a complex process that occurs when blood flow is restored after myocardium infarction (MI) with exacerbated tissue damage. Macrophages, essential cell type of the immune response, play an important role in MIRI. Macrophage subpopulations, namely M1 and M2, are distinguished by distinct phenotypes and functions. In MIRI, macrophages infiltrate in infarcted
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Exploring the molecular and immune-landscape of lung cancer associated with cystic airspaces Mol. Immunol. (IF 3.6) Pub Date : 2024-03-01 Xiang Zheng, Li Qiu, Ying Huang, Ran Cheng, Sihe Huang, Ke Xu, Weipeng Cai, Yu Deng, Wei Wang, Xi Zhong, Fei Cui, Zhexue Hao, Jun Liu
To explore the molecular biological characteristics of lung cancer associated with cystic airspaces (LCCA) and its potential roles on prognosis. A total of 165 LCCAs and 201 non-LCCAs were enrolled in this study. Bulk RNA sequencing was implemented in eight LCCAs and nine non-LCCAs to explore the differentially expressed genes. TCGA data were used to analyze LCCA-specific genes that associated with
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Hydrogen ameliorates endotoxin-induced acute lung injury through AMPK-mediated bidirectional regulation of Caspase3 Mol. Immunol. (IF 3.6) Pub Date : 2024-02-29 Qian Li, Min Shi, Yang Ang, Pan Yu, Bing Wan, Bin Lin, Wei Chen, Zichuan Yue, Yadan Shi, Faqi Liu, Hao Wang, Manlin Duan, Yun Long, Hongguang Bao
Septic lung injury is characterized by uncontrollable inflammatory infiltrations and acute onset bilateral hypoxemia. Evidence has emerged of the beneficial effect of hydrogen in acute lung injury (ALI), but the underlying mechanism is unclear. In this research, the recovery action of hydrogen on lipopolysaccharide (LPS)-induced ALI in mice and A549 cells was investigated. The 7-day survival rate and
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Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5 Mol. Immunol. (IF 3.6) Pub Date : 2024-02-29 Zhaohui Shi, Tianfeng Zhao, Dingbo Li, Chong Wang, Yanjie Luo, Yangshan Zheng
Allergic rhinitis (AR) is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens, which leads to mucosal inflammation and barrier dysfunction. The transcription factor forkhead box C1 (FOXC1) has been identified to be associated with allergic inflammation. This study sought to uncover the role of FOXC1 in AR. A murine model of AR was induced by repeated intranasal ovalbumin (OVA)
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The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks Mol. Immunol. (IF 3.6) Pub Date : 2024-02-29 Zhe Liu, Juan Du, Yanhong Wang, Haoyu Song, Ligong Lu, Rui Wu, Chenghao Jin
Salmonella enteritis in poultry can result in reduced immune function, decreased growth rate, and increased mortality. Many farm salmonella strains have developed severe drug resistance and are less susceptible to multiple antibiotics. In the post-antibiotic era, it is of great significance to identify the mechanism of salmonella-induced enteritis in chicks to protect their health and ensure food safety
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Human beta defensin 3 knockdown inhibits the proliferation and migration of airway smooth muscle cells through regulating the PI3K/AKT signaling pathway Mol. Immunol. (IF 3.6) Pub Date : 2024-02-28 Guiying Chen, Yuling Zheng, Nan Wu, Xia Yang, Shuqiang Qu
Asthma, a common pediatric pulmonary disease, significantly affects children’s healthy development. This study aimed to investigate the functions of human β defensin-3 (HBD-3) in asthma progression. For this purpose, blood samples from asthmatic and healthy children were collected. Moreover, the airway smooth muscle cells (ASMCs) were treated with platelet-derived growth factor BB (PDGF-BB) to develop
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Predicting the risk of interstitial lung disease in patients with primary Sjögren's syndrome: Novel nomogram and elevated Th2 cells Mol. Immunol. (IF 3.6) Pub Date : 2024-02-20 Yanlin Wang, Yuhan Jia, Yan Qin, Min Feng, Zhaojun Liang, Xiangcong Zhao, Chong Gao, Hui Guo, Jing Luo
Interstitial lung disease (ILD) is one of the most common pulmonary complications in patients with primary Sjögren’s syndrome (pSS). This study was performed to identify immunological risk factors of pSS-associated ILD (pSS-ILD) and to further establish and evaluate of nomograms predicting the risk of ILD in patients with pSS. A total of 622 patients with pSS (117 with ILD and 505 without lung involvement)
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SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells Mol. Immunol. (IF 3.6) Pub Date : 2024-02-17 Ling Zhang, Wenjing Wang, Ting Chen, Jiuhao Cui, Xin Li, Anran Liu, Rumeng Liu, Liwei Fang, Junhong Jiang, Li Yang, De Wu, Songcheng Ying
Dysfunctional mutations in SAMHD1 cause Aicardi-Goutières Syndrome, an autoinflammatory encephalopathy with elevated interferon-α levels in the cerebrospinal fluid. Whether loss of function mutations in SAMHD1 trigger the expression of other cytokines apart from type I interferons in Aicardi-Goutières Syndrome is largely unclear. This study aimed to explore whether SAMHD1 dysfunction regulated the
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Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis Mol. Immunol. (IF 3.6) Pub Date : 2024-02-17 Ruiyan Liu, Xin Shang, Yu Fu, Ying Wang, Ping Wang, Shuxun Yan
In recent years, mounting evidence has indicated a co-morbid relationship between hypothyroidism and rheumatoid arthritis (RA), however, the shared genetic factors underlying this association remain unclear. This study aims to investigate the common genetic architecture between hypothyroidism and RA. Genome-wide association study (GWAS) summary statistics from recently published studies were utilized
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Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy Mol. Immunol. (IF 3.6) Pub Date : 2024-02-17 Cristina Zanchi, Monica Locatelli, Domenico Cerullo, Verena Aumiller, Daniela Corna, Daniela Rottoli, Steffen Schubert, Marina Noris, Susanna Tomasoni, Giuseppe Remuzzi, Carlamaria Zoja, Ariela Benigni
Complement alternative pathway (AP) dysregulation drives C3 glomerulopathy (C3G), a rare renal disorder characterized by glomerular C3 deposition and glomerular damage, for which no effective treatments are available. Blockade of complement C3 is emerging as a viable therapeutic option. In an earlier study we showed that SLN500, a small interfering RNA targeting liver C3 synthesis, was able to limit
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Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation Mol. Immunol. (IF 3.6) Pub Date : 2024-02-14 Wenxin Sheng, Jianshu Yu, Hao Zhang, Jingbo Zhang
To investigate the anti-inflammatory actions and molecular mechanisms of the sodium/glucose cotransporter 2 (SGLT-2) inhibitor empagliflozin on autoimmune myocarditis. The experimental autoimmune myocarditis (EAM) mouse model was constructed using peptides, and the therapeutic effects of empagliflozin on cardiac inflammation and fibrosis were observed using hematoxylin and eosin (HE), Sirius red staining
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SARS-CoV-2 spike protein receptor binding domain promotes IL-6 and IL-8 release via ATP/P2Y2 and ERK1/2 signaling pathways in human bronchial epithelia Mol. Immunol. (IF 3.6) Pub Date : 2024-02-14 Rui-Gang Zhang, Xing-Jian Liu, Yu-Ling Guo, Chun-Ling Chen
The spike protein of SARS-CoV-2 as well as its receptor binding domain (RBD) has been demonstrated to be capable of activating the release of pro-inflammatory mediators in endothelial cells and immune cells such as monocytes. However, the effects of spike protein or its RBD on airway epithelial cells and mechanisms underlying these effects have not been adequately characterized. Here, we show that
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The role of transforming growth factor beta in myopia development Mol. Immunol. (IF 3.6) Pub Date : 2024-02-10 Hsiangyu Ku, Jamie Jiin-Yi Chen, Wei Chen, Peng-Tai Tien, Hui-Ju Lin, Lei Wan, Gezhi Xu
Myopia is widely recognized as an epidemic. Studies have found a link between Transforming Growth Factor-beta (TGF-β) and myopia, but the specific molecular mechanisms are not fully understood. In this study, a monocular model in tree shrews () was established to verify the molecular mechanism of TGF-β in myopia. The results indicated that there were significant changes in TGF-βs during the treatment
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Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway Mol. Immunol. (IF 3.6) Pub Date : 2024-02-03 Guihua Song, Mengmeng Sun, Yan Zhang, Bingxue Zhang, Minghao Peng, Beibei Bao
Asthma is a common chronic respiratory disease characterized by Th2-type inflammation in the airways. Leucine zip transcription factor-like 1 (LZTFL1) has been implicated in the regulation of Th2-related factors. The knockdown of LZTFL1 resulted in decreased levels of IL-4, IL-5, and IL-13. We hypothesize that LZTFL1 may have an effect on asthma. We established an acute asthmatic mouse model using
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ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury Mol. Immunol. (IF 3.6) Pub Date : 2024-02-03 Jifang Liang, Junkun Zhang, Jixiu Fan, Shuxian Chen, Weidong Wu
Acute lung injury (ALI) is a prevailing and deadly complication of sepsis coupled with increasing incidence and fatality rate. Annexin A3 (ANXA3) has been unraveled to be upregulated during sepsis. This study purposed to assess the role and the mechanism of ANXA3 in sepsis-induced ALI. After the construction of mouse model of sepsis, the pathological changes of mice lung tissues were estimated by H&E
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IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway Mol. Immunol. (IF 3.6) Pub Date : 2024-02-01 Chunming Xiong, Bohan Li, Renxing Song, Zizhe Ma, Sally A. Huber, Wei Liu
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α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance Mol. Immunol. (IF 3.6) Pub Date : 2024-01-26 Yuying Yang, Yuqing Deng, Guoqiang Zhang, Xiaoting Xu, Xiaoxiao Xiong, Si Yu, Fanrong Peng, Xuyan Tian, Weiying Ye, Huanpeng Chen, Bolan Yu, Zhonghua Liu, Xixin He, Zhaofeng Huang
Th17 cell, an important subpopulation of helper T cell, plays an important role in the development of inflammatory bowel disease (IBD) and is thought to be a potential target for the treatment of IBD. In our previous study, we demonstrated that α-mangostin could relieve lupus nephritis via inhibiting Th17 cell function. In our preliminary study, we obtained four derivatives by adding chemical modification
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SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation Mol. Immunol. (IF 3.6) Pub Date : 2024-01-24 Dongming Wu, Yong Wang, Jian Xu, Dong Wang, Jiawei Zhang, Lijuan Meng, Yuanchang Hu, Ping Wang, Jinde Lin, Shun Zhou
Background Liver ischemia reperfusion (IR) injury is a common cause of liver dysfunction in patients post liver partial resection and liver transplantation. However, the cellular defense mechanisms underlying IR are not well understood. Macrophage mediated sterile inflammation plays critical roles in liver IR injury. Sorting nexin (SNX) 10, a member of the SNX family which functions in regulation of
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Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization Mol. Immunol. (IF 3.6) Pub Date : 2024-01-24 Takeyuki Shimizu, Lin Sun, Kazuo Ohnishi
During B cell development, pre-B cell receptor (pre-BCR), comprising the immunoglobulin heavy chain (HC) and surrogate light chain (SLC), plays a crucial role. The expression of pre-BCR serves as a certification of HC quality, confirming its ability to associate with the SLC and light chain (LC). In mice lacking SLC, the absence of this quality control mechanism leads to a distorted repertoire of HCs
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Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes Mol. Immunol. (IF 3.6) Pub Date : 2024-01-25 Tetiana Hourani, Mahtab Eivazitork, Thivya Balendran, Kevin MC. Lee, John A. Hamilton, Hong-Jian Zhu, Josephine Iaria, Andrew P. Morokoff, Rodney B. Luwor, Adrian A. Achuthan
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Immunoregulatory function of SP-A Mol. Immunol. (IF 3.6) Pub Date : 2024-01-19 Shu Dong, Hongyuan Pang, Fan Li, Mengqing Hua, Meng Liang, Chuanwang Song
Surfactant protein A (SP-A), a natural immune molecule, plays an important role in lung health. SP-A recognizes and binds microbial surface glycogroups through the C-type carbohydrate recognition domain, and then binds corresponding cell surface receptors (such as C1qRp, CRT-CD91 complex, CD14, SP-R210, Toll-like receptor, SIRP-α, CR3, etc.) through collagen-like region, and subsequently mediates biological
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Investigation of T cell-related hub genes in diabetic nephropathy by bioinformatics analysis and experiment validation Mol. Immunol. (IF 3.6) Pub Date : 2024-01-19 Hongyan Luo, Lirong Yang, Danna Ma, Xi Bao, Guoqing Zhang, Bo Li, Shilu Cao, Shunyao Liu, Li Bao, , Yali Zheng
Diabetic nephropathy(DN) remains a significant risk factor for cardiovascular and all-cause mortality, and end-stage renal disease (ESRD) associated with it is growing in prevalence.However, there is absolutely no curative strategy for DN. We subjected db/db and control mouse kidneys to transcriptional sequencing analysis to obtain transcriptome expression profile data in the diabetic nephropathy.We
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A novel Mycobacterium Tuberculosis antigen, MTB48 enhances inflammatory response in LPS-induced RAW264.7 macrophage immune cells Mol. Immunol. (IF 3.6) Pub Date : 2024-01-17 Jun-Young Park, Hee-Do Kim, Fukushi Abekura, Seung-Hak Cho, Cheorl-Ho Kim
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Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway Mol. Immunol. (IF 3.6) Pub Date : 2024-01-12 Dong Yuan, Zhipeng Zheng, Cheng Shen, Jun Ye, Li Zhu
C1s enzyme (active C1s) is a subunit of the complement C1 complex that cleaves low-density lipoprotein receptor-related proteins 5 and 6, leading to Wnt/β-catenin pathway activation in some cell lines. Macrophages have two major functional polarization states (the classically activated M1 state and the alternatively activated M2 state) and play an essential role in atherosclerosis. An increasing amount
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N-terminal ectodomain of BTNL2 inhibits T cell activation via a non-canonical interaction with its putative receptor that results in a delayed progression of DSS-induced ulcerative colitis Mol. Immunol. (IF 3.6) Pub Date : 2024-01-13 Anita Hansda, Saumyadeep Goswami, Sarbartha Mukherjee, Aditya J. Basak, Shirin Dasgupta, Pritam Kumar Roy, Dibyendu Samanta, Gayatri Mukherjee
Butyrophilin-like 2 (BTNL2) is a T cell inhibitory molecule that interacts with unknown binding partners to modulate the immune response in a number of inflammatory and autoimmune diseases. In this study, we found that the inhibitory effects of BTNL2 on T cell activation and effector functions can be executed by its N-terminal IgV domain (BTNL2 IgV1) alone. Structure-guided mutation of key residues
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HDAC6-MYCN-CXCL3 axis mediates allergic inflammation and is necessary for allergic inflammation-promoted cellular interactions Mol. Immunol. (IF 3.6) Pub Date : 2024-01-03 Yoojung Kwon, Yunji Choi, Misun Kim, Hyein Jo, Myeong Seon Jeong, Hyun Suk Jung, Dooil Jeoung
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Towards detection of structurally-diverse glycated epitopes in native proteins: Single-chain antibody directed to non-A1c epitope in human haemoglobin Mol. Immunol. (IF 3.6) Pub Date : 2024-01-04 Miss Lucia Gaetani, Isabel Campos Pinto, Meng Li, Peter O’Connor, Susan Giorgi-Coll, Matthew Tyreman, Katherine L. Rumary, James A. Schouten, Paul Davis, Ann M. Dixon
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Single-cell transcriptional profiling reveals aberrant gene expression patterns and cell states in autoimmune diseases Mol. Immunol. (IF 3.6) Pub Date : 2023-12-29 Zhenyu Liu, Wujun Wei, Junning Zhang, Xueli Yang, Zhihui Feng, Biao Zhang, Xianliang Hou
Multiple sclerosis(MS), primary Sjögren syndrome (pSS), and systemic lupus erythematosus (SLE) share numerous clinical symptoms and serological characteristics. We analyzed 153550 cells of scRNA-seq data of 17 treatment-naive patients (5 MS, 5 pSS, and 7 SLE) and 10 healthy controls, and we examined the enrichment of biological processes, differentially expressed genes (DEGs), immune cell types, and
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Recombinant human scFv antibody fragments against phospholipase A2 from Naja naja and Echis carinatus snake venoms: In vivo neutralization and mechanistic insights Mol. Immunol. (IF 3.6) Pub Date : 2023-12-27 Amit Kumar, Zaid Kamal Madni, Shivam Chaturvedi, Dinakar M. Salunke
Snake envenomation results in a range of clinical sequelae, and widely used animal-based conventional antivenoms exhibit several limitations including the adverse immunological effects in human snake bite victims. Therefore, human monoclonal anti-snake venom antibodies or fragments can be an alternate therapy for overcoming the existing limitations. We developed venom-neutralizing humanized scFv antibodies
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Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury Mol. Immunol. (IF 3.6) Pub Date : 2023-12-27 Yao Wang, Sha She, Wenyuan Li, Jiling Zhu, Xun Li, Fan Yang, Kai Dai
Objective Cells can produce stress granules (SGs) to protect itself from damage under stress. The cGAS-STING pathway is one of the important pattern recognition pathways in the natural immune system. This study was investigated whether human mesenchymal stem cells (hMSCs) could protect the liver by inducing M2 macrophages to produce SGs during acute drug induced liver injury (DILI) induced by acetaminophen
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Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration Mol. Immunol. (IF 3.6) Pub Date : 2023-12-23 Siddharth Jindal, Dennis Vestergaard Pedersen, Nimish Gera, Julian Chandler, Rekha Patel, Alyssa Neill, Josh Cone, Yuchun Zhang, Chao-Xing Yuan, Ellen E. Millman, Dan Carlin, Bridget Puffer, Douglas Sheridan, Gregers Rom Andersen, Paul Tamburini
The bispecific antibody gefurulimab (also known as ALXN1720) was developed to provide patients with a subcutaneous treatment option for chronic disorders involving activation of the terminal complement pathway. Gefurulimab blocks the enzymatic cleavage of complement component 5 (C5) into the biologically active C5a and C5b fragments, which triggers activation of the terminal complement cascade. Heavy-chain
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Corrigendum to: “Identification of an AnnexinB9 involve in white spot syndrome virus infection in red claw crayfish Cherax quadricarinatus” [Mol. Immunol. 162 (2023) 21–29] Mol. Immunol. (IF 3.6) Pub Date : 2023-12-21 Shan Liu, Tengping Jiang, Lei Dai
Abstract not available
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The SpyCatcher-SpyTag interaction mediates tunable anti-tumor cytotoxicity of NK cells Mol. Immunol. (IF 3.6) Pub Date : 2023-12-20 Changjiang Guo, Xiali Guo, Xiaojuan Li, Meng Dong, Xiang Wang, Shizhuang Cheng, Lingtong Zhi, Zhiyuan Niu, Wuling Zhu
Chimeric antigen receptor (CAR)-modified T and NK cell immunotherapy is a promising approach for cancer treatment. Due to the lack of tunability in anti-tumor activity, conventional CAR therapies have limited efficacy at low tumor antigen densities. To tune the CAR response to tumor cell surface antigens, we have developed a split CAR using the SpyCatcher-SpyTag system. The SpyCatcher serves as the
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B7-H3 promotes angiogenesis in rheumatoid arthritis Mol. Immunol. (IF 3.6) Pub Date : 2023-12-21 Jie Yang, Jian Xiong, Yuling Sun, Li Gu, Yachun Chen, Yundi Guo, Cuiping Liu, Jing Sun
Objective The primary pathological changes of rheumatoid arthritis (RA) include chronic synovial inflammation, bone destruction, and aggressive pannus formation on cartilage, in which angiogenesis plays a critical role. B7-H3, an important immune checkpoint molecule, represents a novel target in tumor therapy and plays a significant role in the pathogenesis of autoimmune diseases. However, its biological
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Mosquito allergy: Immunological aspects and clinical management Mol. Immunol. (IF 3.6) Pub Date : 2023-11-30 Jose Fernando Cantillo, Elizabeth Garcia, Enrique Fernandez-Caldas, Leonardo Puerta
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Corrigendum to “DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells” [Mol. Immunol. 131 (2021) 6222] Mol. Immunol. (IF 3.6) Pub Date : 2023-11-24 Can Li, Weiwei Liu, Fang Wang, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
Abstract not available
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Immunomodulation by mesenchymal stem cells during osteogenic differentiation: Clinical implications during bone regeneration Mol. Immunol. (IF 3.6) Pub Date : 2023-11-26 Aditi Mahajan, Shalmoli Bhattacharyya
Critical bone defects resulting in delayed and non-union are a major concern in the field of orthopedics. Over the past decade, mesenchymal stem cells (MSCs) have become a promising frontier for bone repair and regeneration owing to their high expansion rate and osteogenic differentiation potential ex vivo. MSCs have also long been associated with their ability to modulate immune response in the recipients
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Molecular cloning of the hepcidin gene from crescent sweetlips (Plectorhinchus cinctus) and characterization of its encoded antimicrobial peptide Mol. Immunol. (IF 3.6) Pub Date : 2023-11-24 Peixin Wang, Zhongjing Lin, Shaoling Lin, Yujie Dai, Baodong Zheng, Yi Zhang, Jiamiao Hu
Hepcidin has been identified as an important antimicrobial peptide exerting important innate immunomodulatory activities in many fish species. In the present study, reverse transcription PCR coupled with the rapid amplification of cDNA ends was used to obtain the full-length cDNA of the crescent sweetlips hepcidin gene, which is 829 bp in length and includes an 273 bp ORF encoding a peptide with 90
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Identification and functional characterization of Caspase-9 in goldfish (Carassius auratus L.) in response to Aeromonas hydrophila infection Mol. Immunol. (IF 3.6) Pub Date : 2023-11-25 Xinyuan Yue, Jingyi Liu, Ziqi Ban, Xionglin Li, Jianhu Jiang, Jiasong Xie
Apoptosis plays a pivotal role in the immune response to combat pathogen infections. In mammals, caspase-9, abbreviated as Casp9, plays an irreplaceable role in the initiation phase of the apoptotic cascade. To investigate the role of Casp9 in teleosts, we conducted a functional characterization of Casp9 in goldfish (Carassius auratus L.). The open reading frame of GfCasp9 spans 1296 base pairs (bp)
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Interleukins-6 −174G/C (rs1800795) and −572C/G (rs1800796) polymorphisms and prostate cancer risk Mol. Immunol. (IF 3.6) Pub Date : 2023-11-20 Muhammad Sarfaraz Iqbal, Kaoqing Peng, Nimra Sardar, Muhammad Hasnain Iqbal, Muhammad Usman Ghani, Fouzia Tanvir, Di Gu, Zeng Guohua, Xiaolu Duan
Prostate cancer (PCa) is an aggressive cancer influenced by a complex interplay of genetic and environmental factors. Amongst these risk factors, the impact of Interleukin6 (IL6) gene polymorphisms in PCa risk has received a lot of attention. IL-6 is a cytokine that has been implicated in the pathogenesis of several malignancies, including PCa. Two IL-6 gene polymorphisms, − 174 G/C (rs1800795) and
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Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells Mol. Immunol. (IF 3.6) Pub Date : 2023-11-21 C. Mardones, C. Navarrete-Munoz, ME Armijo, K. Salgado, F. Rivas-Valdes, V. Gonzalez-Pecchi, C. Farkas, A. Villagra, MI Hepp
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Silencing of STUB1 relieves osteoarthritis via inducing NRF2-mediated M2 macrophage polarization Mol. Immunol. (IF 3.6) Pub Date : 2023-11-21 Nan Cao, Danni Wang, Bin Liu, Yu Wang, Wenfeng Han, Jing Tian, Liangbi Xiang, Zheng Wang
Objectives Shifting macrophages towards an anti-inflammatory state is key in treating osteoarthritis (OA) by reducing inflammation and tissue damage. However, the underlying mechanisms guiding this shift remain largely undefined. STUB1, an E3 ubiquitin ligase, known for its regulatory role in macrophage polarization. This study aims to explore the function and underlying action mechanisms of STUB1
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Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the microRNA-410–3p Mol. Immunol. (IF 3.6) Pub Date : 2023-11-17 Zan Jie Feng, Liu Song Wang, Xuan Ma, Kai Li, Xin Yao Li, Yi Tang, Ci Jun Peng
Background Hepatic ischemia-reperfusion (I/R) injury involves inflammatory necrosis of liver cells as a significant pathological mechanism. Catapol possesses anti-inflammatory activity that is extracted from the traditional Chinese medicine, Rehmannia glutinosa. Methods The liver function and histopathology, Oxidative stress, and aseptic inflammatory responses were assessed in vivo, and the strongest
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Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments Mol. Immunol. (IF 3.6) Pub Date : 2023-11-18 Hugo Valencia-Martínez, Lidia Riaño-Umbarila, Timoteo Olamendi-Portugal, José Alberto Romero-Moreno, Lourival D. Possani, Baltazar Becerril
The first toxic component identified against mammals in the venom from Centruroides tecomanus scorpion from Colima, Mexico was Ct1a toxin, which was neutralized by human single chain variable fragment (scFv) RAS27. Venom characterization from these scorpions collected on the Pacific coast of Colima, enabled the identification of a second component of medical importance named Ct71 toxin. Amino acid
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Progesterone-mediated immunoregulation of cytokine signaling by miRNA-133a and 101-3p in Chlamydia trachomatis-associated recurrent spontaneous abortion Mol. Immunol. (IF 3.6) Pub Date : 2023-11-10 Ankita Ray, Tanu Bhati, Renu Arora, Sangita Rastogi
miRNAs regulate the expression of various genes involved in cellular and metabolic pathways in pregnancy related complications including recurrent spontaneous abortion (RSA). Modulation of progesterone and associated pro-inflammatory cytokines by miRNAs in Chlamydia trachomatis-associated RSA is still under investigation. Present study aimed to evaluate the expression/correlation of serum-circulating
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Differential expression of interleukin-35 receptor distinguishes different subsets of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in a mouse endometriosis model Mol. Immunol. (IF 3.6) Pub Date : 2023-11-07 Fengqin Lin, Hongbo Yu, Li Zhang, Jing Zhou, Yuan Cao, Songli Wu, Junjie Wang
The immune system contributes to the pathophysiology of endometriosis. The role of ThGM cells, which produce granulocyte macrophage-colony-stimulating factor (GM-CSF), in the pathogenesis of endometriosis remains unknown. To analyze the features of ThGM cells in endometriosis, a mouse endometriosis model was established. ThGM cells in the spleen, peritoneal fluid (PF), and endometriotic lesions (EL)
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A novel intergenic variant, rs2004339 A/G, of the gene encoding interleukin-40, C17orf99, is associated with risk of rheumatoid arthritis in Iraqi women Mol. Immunol. (IF 3.6) Pub Date : 2023-11-09 Dhuha F.N. Bani-Wais, Ali H. Ad'hiah
Interleukin-40 (IL-40) is a novel cytokine encoded by the chromosome 17 open reading frame 99 (C17orf99) gene. Recent studies have shown that IL-40 levels are significantly up-regulated in patients with rheumatoid arthritis (RA). However, the association of genetic variants of the C17orf99 gene with the risk of RA has not been investigated. In this case-control study, two intergenic variants, rs2004339
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Differential gene expression of cytokines, receptors, and miRNAs in individuals living with HIV-1 and vaccinated against yellow fever Mol. Immunol. (IF 3.6) Pub Date : 2023-11-10 Karine Venegas Macieira, Diogo Gama Caetano, Sheila Maria Barbosa De Lima, Carmem Beatriz Wagner Giacoia-Gripp, Fernanda Heloise Côrtes, Andressa Da Silva Cazote, Adriana De Souza Azevedo Soares, Nathalia Dos Santos Alves, Marcel De Souza Borges Quintana, Marcellus Costa, Luciana Gomes Pedro Brandão, Michelle Morata De Andrade, Beatriz Grinsztejn, Lara Esteves Coelho, Dalziza Victalina De Almeida
Between 2016 and 2018, Brazil faced a yellow fever (YF) outbreak, which led to an expansion of vaccination coverage. The coexistence of the YF outbreak and the HIV-1 epidemic in Brazil raised concerns regarding the immune response and vaccine effectiveness in individuals living with HIV (PLWH). The aim of this study was to investigate the immune response to YF vaccination in PLWH and HIV-uninfected
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Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation Mol. Immunol. (IF 3.6) Pub Date : 2023-11-03 Goutham V. Ganesh, Kunka Mohanram Ramkumar
Pterostilbene (PTS), known for its diverse beneficial effects via Nuclear factor erythroid-2 related factor (Nrf2) activation, holds potential for Diabetic Foot Ulcer (DFU) treatment. However, PTS-mediated Nrf2 regulation in diabetic wounds has yet to be elucidated. We used IC21 macrophage-conditioned media to simulate complex events that can influence the fibroblast phenotype using L929 cells during
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The ELOVL6 homolog in Penaeus vannamei plays a dual role in fatty acid metabolism and immune response Mol. Immunol. (IF 3.6) Pub Date : 2023-10-22 Yuqing Zhou, Jude Juventus Aweya, Zishu Huang, Ying Chen, Ziqiang Tang, Zihao Shi, Zhihong Zheng, Yueling Zhang
In mammals, elongation of very long chain fatty acid protein 6 (ELOVL6), a key enzyme in long chain fatty acids elongation, has been reported to regulate other metabolism processes and immunity, including inflammation in vertebrates. However, little is currently known about the ELOVL6 homolog in invertebrates, especially its role in immune response. In this study, the ELOVL6 ortholog in Penaeus vannamei
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Clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) sepsis and non-SFTS sepsis Mol. Immunol. (IF 3.6) Pub Date : 2023-10-20 Ying Xu, Xilan Yang, Chen Qu, Jian Jia
Severe fever with thrombocytopenia syndrome (SFTS) is a new infectious disease caused by bunyavirus, and the critically cases conform to the definition of sepsis. In order to compare the differences between SFTS sepsis and non-SFTS sepsis, a retrospective analysis was performed. Thirty-seven SFTS sepsis and 96 non-SFTS sepsis patients were enrolled. The clinical characteristics, laboratory results
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ROS-mediated MAPK activation aggravates hyperoxia-induced acute lung injury by promoting apoptosis of type II alveolar epithelial cells via the STAT3/miR-21–5p axis Mol. Immunol. (IF 3.6) Pub Date : 2023-10-14 Song Qin, Jun-ya Liu, Xiao-qin Wang, Bang-hai Feng, Ying-cong Ren, Jie Zheng, Kun Yu, Hong Yu, Kang Li, Feng Zhu, Miao Chen, Xiaoyun Fu, Tao Chen, Zhou-xiong Xing, Hong Mei
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Rac2 mediate foam cell formation and associated immune responses in THP-1 to promote the process of atherosclerotic plaques Mol. Immunol. (IF 3.6) Pub Date : 2023-10-13 Ling Xu, He Ren, Daqing Xie, Feng Zhang, Xiaoxiao Hu, Shu Fang, Hongli Wang, Dan He
Macrophages play an important role in the pathogenesis of atherosclerosis (AS) by mediating oxidative stress, inflammation and lipid metabolism, which can lead to the formation of vascular plaque. The Rac family isoforms of small molecules GTPase are active by binding to GTPase, but are inactivated by binding to GDP, and play a role in the switch of cell information conduction. This experiment adopts
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Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma Mol. Immunol. (IF 3.6) Pub Date : 2023-10-12 Lauren C. Morehead, Brian Koss, Daniel Fil, Billie Heflin, Sarita Garg, Katherine F. Wallis, Alan J. Tackett, Isabelle R. Miousse
Immune checkpoint inhibitor therapy has drastically improved outcomes in treating cancer, particularly in melanoma. However, half of melanoma patients are resistant to treatment. One mechanism used by tumor cells to evade immune attack is to down-regulate major histocompatibility complex (MHC) class I molecules, which are required for cytotoxic CD8 T-cells to eliminate cancer cells. To increase immunotherapeutic
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Comparison and subsets analysis of peripheral CD4+T cells in patients with psoriasis and psoriatic arthritis Mol. Immunol. (IF 3.6) Pub Date : 2023-10-07 Weiqin Gao, Yunxuan Lei, Xin Guo, Yanping Luo, Zhenghua Zhang, Yebin Xi, Weifeng Wang, Wenjie Xia, Zhaojun Wang, Xiaoyin Niu, Guangjie Chen, Tao Yue
Psoriatic arthritis (PsA) is a disease that transformed from psoriasis (PsO), and its underlying mechanisms are still not fully understood. Overactivation of the immune system is a key factor driving inflammatory diseases. Our goal is to define the unbalanced subsets of peripheral blood CD4 +T cells between PsO and PsA patients. Blood samples from 43 patients (23 PsA and 20 PsO) and 36 healthy donors
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The role of the Gas6/TAM signal pathway in the LPS-induced pulmonary epithelial cells injury Mol. Immunol. (IF 3.6) Pub Date : 2023-10-09 Yujing Cheng, Xin Yang, Ying Wang, Quan Ding, Yu Huang, Chan Zhang
Background Acute lung injury (ALI) is an acute inflammatory respiratory disease. The interaction between growth arrest-specific 6 (Gas6) and tyrosine kinases of the Tyro3, Axl, Mer (TAM) family plays an important role in a variety of physiological and pathological processes, including inflammation. In this study, we mainly clarified the mechanism of the Gas6/TAM signal pathway in lipopolysaccharide