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Hecogenin and fluticasone combination attenuates TNBS-induced ulcerative colitis in rats via downregulation of pro-inflammatory mediators and oxidative stress Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2021-01-12 Deepa K. Ingawale; Satish K. Mandlik; Snehal S. Patel
Abstract Objective Ulcerative colitis is common types of severe, progressive, idiopathic inflammatory bowel disease that involves the mucosal lining of the large intestine. The purpose of the study is to explore the effects of hecogenin in TNBS (2, 4, 6- trinitrobenzene sulfonic acid) induced ulcerative colitis model in rats. Material and methods Thirty Wistar rats were randomized into five groups:
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Lactoferrin suppresses LPS-induced expression of HMGB1, microRNA 155, 146, and TLR4/MyD88/NF-кB pathway in RAW264.7 cells Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2021-01-12 Maryam Nemati; Saeideh Akseh; Maryam Amiri; Hamid Reza Nejabati; Ahmadreza Jodati; Nazila Fathi Maroufi; Yousef Faridvand; Mohammad Nouri
Abstract Objective This current study evaluated the underlying mechanisms of LF against the inflammatory microRNAs (miRNAs), HMGB1 expression, and TLR4-MyD88-NF-кB pathway in LPS-activated murine RAW264.7 cells. Methods MTT assay was used to assess cell metabolism and the cell culture levels of the cytokines (TNF-α, IL-6) were evaluated by Enzyme-linked immunosorbent assay (ELISA). The expression of
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Protective effect of the intravenous anesthetic propofol against a local inflammation in the mouse carrageenan-induced air pouch model Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2021-01-11 Takefumi Inada; Takahiko Kamibayashi
Abstract Aim: 2,6-Di-isopropylphenol (propofol) is an intravenous general anesthetic widely used in the operating room for general anesthesia and in the intensive care unit for sedation. The mouse air pouch model is versatile in studying the anti-inflammatory effect of a drug on a local inflammation, which is induced by a variety of substances. In this study, using the carrageenan-induced air pouch
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Interleukin-39 exacerbates concanavalin A-induced liver injury Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2021-01-07 Yan Li; Luping Gong; Linjie Weng; Xiuhe Pan; Chaobo Liu; Mingcai Li
Abstract Background Interleukin (IL)-39 is a novel member of IL-12 family and has been reported to play a pro-inflammatory role in lupus-like mice, but its function in concanavalin A (ConA)-induced liver injury is currently unclear. Materials and methods In this study, we investigated the effects of IL-39 expression in a mouse model of ConA induced-hepatitis. We first showed that delivery of plasmid
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Statins as an adjunctive therapy for COVID-19: the biological and clinical plausibility Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2021-01-06 Tarek Kashour; Rabih Halwani; Yaseen M. Arabi; M. Rizwan Sohail; John C. O’Horo; Andrew D. Badley; Imad M. Tleyjeh
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus disease 2019 (COVID-19) has infected millions of individuals and has claimed hundreds of thousands of human lives worldwide. Patients with underlying cardiovascular conditions are at high risk for SARS-CoV-2 infection, and COVID-19 patients have high incidence of cardiovascular complications such as
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Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2021-01-06 Yinghua Li; Lili Cao; Zhida Qian; Qingyun Guo; Xiaocen Niu; Lili Huang
Abstract Background Previous studies have demonstrated that mifepristone in the daily low-dose affects the function of endometrium. These researches also implied an alteration of endometrium immune balance, which might be involved in regulating endometrial function. However, the detailed mechanisms remain to be further explored. Methods In this study, the expressions of CD80, CD86, and ICAM-1 in dendritic
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Different aspects of convalescent plasma therapy for COVID-19 treatment; a critical review Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-12-27 Sitaram Khadka; Shameem Nisar; Nawazish-i-Husain Syed; Dhan Bahadur Shrestha; Pravash Budhathoki
Abstract The novel coronavirus disease (COVID-19) has been declared a pandemic by the World Health Organization (WHO) and is ominously threatening the survival of humankind on the whole planet. With a quick spread of the outbreak from its origin, Wuhan, China, to almost all over the world, it has affected more than seven million people to date, hence it has devastated every part of the infrastructural
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MRGPRX2 is critical for clozapine induced pseudo-allergic reactions Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-12-17 Di Wei; Tian Hu; Ya-jing Hou; Xiang-jun Wang; Jia-yu Lu; Shuai Ge; Cheng Wang; Huai-zhen He
Abstract Background Clozapine is one of the most widely used second-generation antipsychotics in clinic. However, allergy-like symptoms such as rash and angioedema have been reported frequently, and the mechanism is still not clear. Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast cells is a crucial receptor for drug induced pseudo-allergic reactions. Therefore, we explored whether
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Regulatory effect of glutathione on treg/Th17 cell balance in allergic rhinitis patients through inhibiting intracellular autophagy Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-12-07 Yuqin Fan; Chenchen Yang; Jieyu Zhou; Xuefeng Cheng; Yu Dong; Qin Wang; Zhentao Wang
Abstract Background Glutathione is a potential therapy for systemic lupus erythematosus, but its role in allergic rhinitis (AR) has not been determined. This report probed into the actions of glutathione in AR, so as to supplement evidence for a therapeutical countermeasure for AR. Methods In this study, peripheral blood mononuclear cells (PBMCs) of patients were extracted and processed with glutathione
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Inhibitory activity of narirutin on RBL-2H3 cells degranulation Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-12-03 Liyan Niu; Jihao Wei; Xuwen Li; Yongri Jin; Xiaolei Shi
Abstract Context: It is an efficient strategy to apply inhibition of mast cell degranulation for evaluating anti-allergic effects of compounds. Previous works confirmed that narirutin had anti–allergic activity in OVA induced allergic asthma murine model. However, the mechanism is not clear. Objective: Here, inhibitory mechanism of narirutin on RBL-2H3 cells degranulation was investigated. Materials
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Etidronate down-regulates Toll-like receptor 2 ligand-inducedchemokine production by inhibiting MyD88 expression and NF-κB activation Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-11-29 Naohito Yambe; Riyoko Tamai; Izumi Mashima; Yusuke Kiyoura
Abstract Objective Pretreatment of J774.1 cells with etidronate, a non-nitrogen-containing bisphosphonate (non-NBP) used as an antibone resorptive drug, was previously reported to inhibit Toll-like receptor (TLR) 2 agonist-induced proinflammatory cytokine production. The present study aimed to examine the effects of etidronate on chemokine production by human monocytic U937 cells incubated with Pam3Cys-Ser-(Lys)4
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New perspectives in bronchial asthma: pathological, immunological alterations, biological targets, and pharmacotherapy. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-27 Deepa S Mandlik,Satish K Mandlik
Abstract Asthma is the most common, long-lasting inflammatory airway disease that affects more than 10% of the world population. It is characterized by bronchial narrowing, airway hyperresponsiveness, vasodilatation, airway edema, and stimulation of sensory nerve endings that lead to recurring events of breathlessness, wheezing, chest tightness, and coughing. It is the main reason for global morbidity
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Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-10-21 Jianping Sheng,Baohang Zhang,Yongfeng Chen,Fuxiang Yu
Abstract Background Capsaicin is a chili pepper extract with multiple therapeutic properties including anti-liver fibrosis. However, the paucity of its underlying mechanisms limited its widely clinical application. Methods In the present study, carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and transforming growth factorβ1 (TGFβ1) was used to mimic liver fibrosis in vitro. Flow
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Immunohistochemical analysis of protective effects of maternal fingolimod on the placenta and fetal lung and brain in chorioamnionitis-induced preterm birth rat model. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-16 And Yavuz,Mekin Sezik,Serenat Eris Yalcin,Halil Asci,Ozlem Ozmen
Abstract Objectives Fingolimod (FIN) is used for multiple sclerosis treatment and has potential antiapoptotic and anti-inflammatory effects. We aimed at expanding our knowledge on various immunohistochemical markers for elucidating the possible mechanisms of action of fingolimod in the placenta and fetal lung and brain. Methods Sixteen pregnant rats were divided into four groups. On gestational day
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Immunological effects of AFM1 in experimental subchronic dosing in mice prevented by lactic acid bacteria. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-24 Jalila Ben Salah-Abbès,Hela Belgacem,Khawla Ezdini,Marwa Mannai,Ridha Oueslati,Samir Abbès
Abstract Aim Recently, higher contamination by aflatoxin M1 (AFM1) has been detected in many countries. Unfortunately, many tons of contaminated milk and milk byproducts are removed from the food chain to avoid human contamination; as a consequence of higher economic losses. Fewest number of studies are interested to AFM1 detoxification using lactic acid bacteria. Materials and methods In this study
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Nicorandil and atorvastatin attenuate carbon tetrachloride – induced liver fibrosis in rats Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-10-19 Asmaa Ramadan Abdel-Sattar; Ali Ahmed Abo-Saif; Amira M. Aboyoussef
Abstract Purpose The present study aimed to evaluate the possible hepatoprotective effects of nicorandil and atorvastatin against experimentally induced liver fibrosis. Materials and methods Wistar male rats wereassigned tofivegroups; control group, fibrosis group, the remaining three groups received in addition to CCl4, N-acetyl cysteine (300 mg/kg), nicorandil(15 mg/kg) and atorvastatin (20 mg/kg)
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Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-11-03 Xiao-Sha Li; Xue-Yong Tang; Wei Su; Xin Li
Abstract Introduction Vitiligo is the most common type of depigmented skin disease. Cellular oxidative stress caused by reactive oxygen species (ROS) has been implicated in the pathogenesis of vitiligo. Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway plays an important role in melanocytes against hydrogen peroxide (H2O2) induced oxidative stress. In addition, vitexin
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Discovery of a potential biomarker for immunotherapy of melanoma: PLAC1 as an emerging target Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-10-26 Ahmad-Reza Mahmoudi; Roya Ghods; Azadeh Rakhshan; Zahra Madjd; Mohammad-Reza Bolouri; Jafar Mahmoudian; Shaghayegh Rahdan; Mohammad-Reza Shokri; Shima Dorafshan; Mehdi Shekarabi; Amir-Hassan Zarnani
Abstract Background Melanoma has increased in incidence worldwide prompting investigators to search for new biomarkers for targeted immunotherapy of this disease. Placenta specific 1 (PLAC1) is a new member of cancer-testis antigens with widespread expression in many types of cancer. Here, we aimed to study for the first time the expression pattern of PLAC1 in skin cancer samples including cutaneous
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Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells – induction of MDSC by lipid vesicles (liposome) Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-11-01 Yoichiro Yoshida; Tsunehisa Nagamori; Emi Ishibazawa; Hiroya Kobayashi; Tomoko Kure; Hiromi Sakai; Daisuke Takahashi; Mitsuhiro Fujihara; Hiroshi Azuma
Abstract Context Effects of liposomal particles on immune function have not been adequately investigated. Earlier reports indicate that intravenous injection of rats with pegylated liposomes comprising chemically defined specific lipids produces myeloid derived suppressor-cell (MDSC)-like cells in the spleen. Objectives After liposome injection, we sought a cell surface marker expressed specifically
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Donepezil protects glycerol-induced acute renal failure through the cholinergic anti-inflammatory and nitric oxide pathway in rats Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-11-12 Guodong Sun; Jialei Wang; Pan Wang; Huimin Ren; Yuedong Yue; Zhengmin Song; Xiaobin Fu
Abstract Objectives Inflammation as well as oxygen metabolite play important roles in renal injury during pathogenesis of rhabdomyolysis induced myoglobinuric acute renal failure (ARF). The aim of this study was to investigate the protective effects of donepezil on immune responses in rats with glycerol-induced ARF. Methods Sixty male rats were randomly divided into six groups, the rats were given
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Effects of treatment with hydroxychloroquine on the modulation of Th17/Treg ratio and pregnancy outcomes in women with recurrent implantation failure: clinical trial Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-11-14 Sonia Sadeghpour; Morteza Ghasemnejad Berenji; Hamid Nazarian; Tohid Ghasemnejad; Mohammad Hadi Nematollahi; Sina Abroon; Shahrokh Paktinat; Heidar Heidari Khoei; Hojjat Ghasemnejad berenji; Marefat Ghaffari Novin
Abstract Aim The imbalance of Th17/Treg cells has been recently suggested as a new risk factors for recurrent implantation failure (RIF). Furthermore Th17/Treg cells are involved in immune regulation in peripheral blood and endometrial tissue of patients with RIF. In this research, we investigated the effects of Hydroxychloroquine (HCQ) on the level and function of Th17 and Treg cells in women with
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Biochemical and immunological aspects of Covid-19 infection and therapeutical intervention of oral low dose cytokine therapy: A systematic review Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-10-26 Ratheesh M; Sheethal S; Svenia P Jose; Sony Rajan; Sulumol Thomas; Tariq Jagmag; Jayesh Tilwani
Abstract The novel coronavirus (SARS-CoV-2) pandemichas now spread to all corners of the world. It causes severe respiratory syndromes which is one of the leading causes of death. Evidence shows that the novel SARS-CoV-2 has close similarities with other coronaviruses, SARS and MERS. So, SARS-CoV-2 might use the similar mechanisms of these viruses to attack the host cells. The severity of COVID-19
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Deciphering Vaccines for COVID-19: Where do we stand TODAY? Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-10-14 Tushar Baviskar; Dezaree Raut; Lokesh Kumar Bhatt
Abstract Pneumonia of unknown etiology was detected in a few patients in Wuhan City, Hubei Province, China. The causative agent was named as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the World Health Organisation (WHO). The disease caused by this virus was named as a new coronavirus disease: COVID-19. The disease has a global impact affecting more than 200 nations including
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Expression of concern Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-10-12
(2020). Expression of concern. Immunopharmacology and Immunotoxicology. Ahead of Print.
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Dual role of sirtuin 1 in inflammatory bowel disease. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-07-12 Karam Devi,Nirmal Singh,Amteshwar Singh Jaggi
Silent information regulator-1 (SIRT-1), is a member of the class III group of histone deacetylases and is collectively called sirtuins. There have been preclinical and clinical studies indicating the downregulation and decreased activity of sirtuin 1 in various inflammatory bowel disease models. Furthermore, the downregulation of sirtuin 1 is responsible for the sustained production of proinflammatory
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The double-edged role of IL-22 in organ fibrosis. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-04 Jia Chen,RathnaSilviya Lodi,Shiqing Zhang,Zhaoliang Su,Yan Wu,Lin Xia
Fibrosis is unregulated tissue repair in damaged or diseased organs, and the accumulation of excess extracellular matrix (ECM) impacts the structure and functions of organs, leading to death. Fibrosis is usually triggered by inflammation and tissue damage, and inflammatory mediators stimulate the proliferation of myofibroblasts and the excessive production of ECM. The IL-10 family cytokines play important
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Contribution of inflammasome complex in inflammatory-related eye disorders and its implications for anti-inflammasome therapy. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-29 Seyed Ahmad Rasoulinejad,Ahmad Karkhah,Alireza Paniri,Kiarash Saleki,Marzieh Pirzadeh,Hamid Reza Nouri
Inflammasome complex is regarded as a major molecular regulator that exerts a significant function in caspase-1 activation and consequently, the development of cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). The secretion of these cytokines may induce inflammation. The role of inflammasomes in the pathologic process of eye-related illnesses like glaucoma, age-related macular degeneration
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Toll-like receptor (TLR) gene expression and immunostimulatory effect of CpG oligonucleotides in hormone receptor positive cell line T47D and triple negative breast cancer cell line MDA-MB-468. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-06 Sudhakar Natarajan,Mohan Ranganathan
Background We investigated the expression of TLR genes and the effects of CpG ODN in Estrogen Receptor positive, Progesterone Receptor positive breast cancer cell line (T47D) and a triple-negative breast cancer cell line (MDA-MB-468) followed by studying the immunostimulatory activity of CpG oligonucleotides in breast cancer cell lines T47D and MDA-MB-468. Materials and Methods We evaluated the expression
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HP-NAP ameliorates OXA-induced atopic dermatitis symptoms in mice. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-02 Xun Guo,Cong Ding,Jike Lu,Tingting Zhou,Taotao Liang,Zhenyu Ji,Peng Xie,Xin Liu,Qiaozhen Kang
Background Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by disequilibrium between Th1/Th2 lymphocytes. Helicobacter pylori neutrophil-activating protein (HP-NAP) has been reported that it has the potential immunomodulatory effect able to regulate the Th1/Th2 balance. Objective This study aimed to investigate the therapeutic effect of HP-NAP in AD mice model. Methods The
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Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-20 Ramachandran Vidhya,Carani Venkatraman Anuradha
Context Obesity is a chronic low-grade inflammatory state associated with immune cell infiltration into the adipose tissue (AT). We hypothesize that the anti-obesity and anti-inflammatory effects of troxerutin (TX) are mediated through inhibition of elastase. Objective To determine the inhibitory effect of TX on elastase in vitro and in tumor necrosis factor alpha (TNFα) induced 3T3-L1 adipocytes and
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Atractylenolide III attenuates bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-29 Bin Huai,Jiyu Ding
Background Bleomycin (BLM) is a chemotherapy drug used to treat cancer, one of which side effects is that it can lead to pulmonary fibrosis (PF). Atractylenoide III (AtrIII), derived from the dried roots of rhizoma atractylodis of compositae, is one of the main active substances of rhizoma atractylodis. It has anti-inflammatory, anti-tumor and other effects. This study aimed to investigate whether
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Magnesium isoglycyrrhizinate ameliorates concanavalin A-induced liver injury via the p38 and JNK MAPK pathway. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-29 Yudi Gao,Yuan Tian,Xiangying Zhang,Xiaohui Zhang,Zhongping Duan,Feng Ren,Yu Chen
Context Acute liver failure is a serious disease caused by a variety of factors, and immunological injury is an important pathological process. Comprehensive liver treatment efficacy is poor, and the mortality rate is high. Magnesium isoglycyrrhizinate (MgIG) is a new glycyrrhizin drug extracted from the traditional Chinese medicine licorice. The mechanism by which MgIG regulates ConcanavalinA (ConA)-induced
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Bromosulfophthalein suppresses inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-29 Fuai Cui,Sean B Sequeira,Zhenyue Huang,Guowei Shang,Quanjun Cui,Xinlin Yang
Objective It has been reported that glutathione (GSH), the most abundant cellular antioxidant, can inhibit production of pro-inflammatory cytokines by activated macrophages. Bromosulfophthalein (BSP) has been recognized as an inhibitor of the efflux of reduced GSH from cells, leading to an increase in the intracellular GSH level. In this study, we evaluated, for the first time, whether BSP possessed
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Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4/NF-kB signaling pathway. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-25 Hasan Yousefi-Manesh,Pegah Dejban,Faiza Mumtaz,Alireza Abdollahi,Mohsen Chamanara,Ahmadreza Dehpour,Amin Hasanvand,Amir Rashidian
Aim The purpose of the present study is to explore the anti-inflammatory potential of risperidone in acetic acid-induced rat colitis through inhibition of TLR4/NF-kB pathway. Methods Acute colitis induction was done by intra-rectal administration of 2 mL of 4% diluted acetic acid solution. Two h after colitis induction, dexamethasone (2 mg/kg) as standard drugorrisperidone (2, 4 and 6 mg/kg) were administered
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Amphiregulin alleviated concanavalin A-induced acute liver injury via IL-22. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-04 Qili Wu,Jingrou Chen,Xiaoli Hu,Yinhong Zhu,Shujuan Xie,Changyou Wu,Zhong Pei,Shiqiu Xiong,Yanwen Peng
Objectives Amphiregulin (Areg), a glycoprotein from the epidermal growth factor receptor (EGFR) ligand family, has a well-documented protective role against tissue injury; however, its effects on immune-mediated liver injury are still unclear. Here, we used a concanavalin A (ConA)-induced acute liver hepatitis model to explore the effects of Areg on immune-mediated acute liver injury. Materials and
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Immunotoxicological effects triggered by the rattlesnake Crotalus durissus cumanensis, mapanare (Bothrops colombiensis) venoms and its purified fractions on spleen and lymph nodes cells. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-02 María M Pulido-Méndez,Elvia Azuaje,Alexis Rodríguez-Acosta
Purpose: The snakes in Venezuela vary in their different venom composition amid the species. In this sense, studies have been carried out elucidating mechanisms related to their immunostimulatory and/or immunosuppressive effects in vitro, measuring inhibition or stimulation on the mice spleen and lymph nodes lymphocytes under the rattlesnake (Crotalus durissus cumanensis) (Cdc) and mapanare (Bothrops
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Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-29 Basel A Abdel-Wahab,Fares E M Ali,Saad A Alkahtani,Ali M Alshabi,Mater H Mahnashi,Emad H M Hassanein
Objectives The fact that methotrexate (MTX) is hepatotoxic is an important reason to limit its clinical use. Rebamipide (REB) has antioxidant and anti-inflammatory properties and is useful for the treatment of gastro-duodenal ulcers. This study investigated the impact and protective mechanisms of REB against MTX-induced hepatotoxicity in rats. Materials and Methods Animals were divided into four groups
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Steviol, the active principle of the stevia sweetener, causes a reduction of the cells of the immunological system even consumed in low concentrations. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-02 Thaís Pasqualli,Pamella Eduardha Espindola Chaves,C Lavínia da Veiga Pereira,Élvio Adílio Serpa,Luís Flávio Souza de Oliveira,Michel Mansur Machado
Aim Steviol is a natural diterpenoid glycoside isolated from Stevia rebaudiana Bertoni leaves and widely used as a non-caloric sweetener. In addition to their sweet taste, Steviol glycosides may also have some therapeutic benefits. There are few reports on the cytotoxicity of Steviol in human cells. Our objective was to test this sweetener under and at average concentrations of consumption, evaluating
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Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund's adjuvant (CFA)-induced arthritis model of rats. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-02 Stephen Adeniyi Adefegha,Nathieli Bianchin Bottari,Daniela Bitencourt Leal,Cínthia Melazzo de Andrade,Maria Rosa Schetinger
Background This study sought to assess the effect of hesperidin on serum inflammatory cytokines and oxidative damage in liver of complete Freund’s adjuvant (CFA)-induced arthritic rats. Method Fifty-six adult female Wistar rats (220–250 g) were acclimatized for two weeks. Intraplantar injection of CFA was done for the induction of arthritis and confirmed on the 14th day prior to oral administration
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Kupffer cell inactivation ameliorates immune liver injury via TNF-α/TNFR1 signal pathway in trichloroethylene sensitized mice. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-13 Jia-Xiang Zhang,Qiong-Ying Xu,Yi Yang,Na Li,Yan Zhang,Li-Hua Deng,Qi-Xing Zhu,Tong Shen
Abstract Aim: The present study aims to explore the important role of Kupffer cell and its related cytokine TNF-α in immune liver injury induced by trichloroethylene (TCE). Methods 36 female BALB/c mice were selected and randomly divided the mice into four groups. We established a BALB/c mouse model of TCE sensitization and pretreatment with GdCl3 (40 mg/kg) by intraperitoneal injection during the
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Future perspective: biologic agents in patients with severe COVID-19. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-09-04 Arzu Didem Yalcin,Ata Nevzat Yalcin
The SARS-CoV-2 is a β-CoV, which is enveloped by non-segmented positive- stranded RNA virüs. When β-CoV infects the respiratory tract, it can cause mild and/or severe acute respiratory syndrome with consequent release of cytokines/mediators, including interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8(CXCL8), IL-10, IP10, IL-12, IL-13, IL-17, IL-33, IL-25, IL-37, IL-38, GCSF, GM-CSF, HGF,IP-10
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Immunotoxinological effects triggered by the rattlesnake Crotalus durissus cumanensis, mapanare (Bothrops colombiensis) venoms and its purified fractions on spleen and lymph nodes cells Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-17 María. M. Pulido-Méndez; Elvia Azuaje; Alexis Rodríguez-Acosta
The snakes in Venezuela vary in their different venom composition amid the species. In this sense, studies have been carried out elucidating mechanisms related to their immunostimulatory and/or immunosuppressive effects in vitro,measuring inhibition or stimulation on the mice spleen and lymph nodes lymphocytes under the rattlesnake (Crotalus durissus cumanensis)(Cdc) and mapanare (Bothrops colombiensis)
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Amphiregulin Alleviated Concanavalin A-induced Acute Liver Injury via IL-22 Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-08-17 Qili Wu; Jingrou Chen; Xiaoli Hu; Yinhong Zhu; Shujuan Xie; Changyou Wu; Zhong Pei; Shiqiu Xiong; Yanwen Peng
Objectives Amphiregulin (Areg), a glycoprotein from the epidermal growth factor receptor (EGFR) ligand family, has a well-documented protective role against tissue injury; however, its effects on immune-mediated liver injury are still unclear. Here, we used a concanavalin A (ConA)-induced acute liver hepatitis model to explore the effects of Areg on immune-mediated acute liver injury. Materials and
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A case of asthma with Behcet's disease: successful treatment with omalizumab and its effects on recurrent aphthous lesions. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-07-01 Arzu Didem Yalcin,Ata Nevzat Yalcin
Context: Monoclonal antibody therapies have revolutionized the treatment of autoinflammatory-immune/genetic disease including spondylarthritis, asthma and rheumatoid arthritis. Behcet’s disease (BD) is a multi-systemic vasculitis, which is generally recurrent aphthous lesions (RAL) as well as ocular and skin lesions. Today, the immunohistopathogenesis of BD is mostly unknown. Method: Omalizumab (Anti-IgE
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Carnosic acid inhibits inflammatory cytokines production in human periodontal ligament cells. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-14 Ikuko Hosokawa,Yoshitaka Hosokawa,Kazumi Ozaki,Takashi Matsuo
Objectives: Carnosic acid (CA), which is one of bioactive compounds from rosemary, has various biological activities. However, the effect of CA on periodontal ligament cells is still uncertain. The aim of this study was to examine the effects of CA on inflammatory cytokines production in human periodontal ligament cells. Methods: Cytokine and chemokine levels were measured by ELISA. Activations of
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The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-14 Yuan Li,Bide Duan,Ying Li,Shujun Yu,Yanyun Wang
Background: Gestational diabetes mellitus (GDM) is a medical complication and metabolic disorder associated with pregnancy. Calycosin is a traditional Chinese herbal medicine that is used for the treatment of multiple diseases. This study focused on exploring the effects and underlying mechanisms of Calycosin on GDM. Methods: The db/+ diabetic mice model of GDM was used to evaluate the effects of calycosin
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Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-09 Cenk Serhan Özverel,Yiğit Uyanikgil,İsmail Karaboz,Ayse Nalbantsoy
Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cancers including 25% of breast cancers. Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic
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Dioscin exhibits anti-inflammatory effects in IL-1β-stimulated human osteoarthritis chondrocytes by activating LXRα. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-09 Haitao Wang,Haifeng Zhu,Xiaodong Yang
Objective: Osteoarthritis (OA) is the most common joint disease that characterized by the degradation of articular cartilage. In this study, we aimed to investigate the anti-inflammatory activity of dioscin on IL-1β-stimulated human osteoarthritis chondrocytes. Methods: The production of PGE2 and NO was measured in this study. MMP1 and MMP3 were detected by ELISA. The expression of LXRα and NF-κB were
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15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene-12-one sensitizes rectal tumor cells to anti-PD1 treatment through agonism of CD11b. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-07 Qingye Zhao,Lin Lu,Guowei Du,Zhihai Wang,Xutong Li,Fang Ju
Purpose: Although immunotherapies have resulted in durable clinical responses, not all tumor types have seen substantial benefit. Extensive recruitment and accumulation of immunosuppressive myeloid cells into the tumor tissues has been postulated as a major mechanism of resistance to immunotherapies. Strategies targeting on single immunosuppressive cell type, in combination with checkpoint inhibitors
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Statement of Retraction: Laquinimod inhibits MMP-induced NLRP3 inflammasome activation in human neuronal cells. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-05
(2020). Retraction: Laquinimod inhibits MMP-induced NLRP3 inflammasome activation in human neuronal cells. Immunopharmacology and Immunotoxicology. Ahead of Print.
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Prophylactic effect of Biochanin A in lipopolysaccharide-stimulated BV2 microglial cells. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-06-01 Mehmet Berköz,Mirosław Krośniak,Ferbal Özkan-Yılmaz,Arzu Özlüer-Hunt
Aim/Purpose of the study:Inhibition of microglial activation using phytochemicals may be a potential candidate for the prevention of neurodegenerative diseases caused by neuroinflammation and oxidative stress. The goal of this study was to investigate the protective role of Biochanin A on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. BV2 microglial cells were treated with LPS in the presence
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Immunotherapy in patients with local HPV infection and high-grade squamous intraepithelial lesion following uterine cervical conization. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-05-19 Stefan Miladinov Kovachev
Objective: To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix.Materials and methods: Over the six-year study period, 32 women with cervical HPV infection following electroconization (loop electrosurgical
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Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-05-18 Jiaji Lei,Yongbin Shen,Guangquan Xv,Zhixin Di,Yongchao Li,Guanghua Li
Objective: The purpose of this study was to explore the protective effects and potential mechanisms of aloin on lipopolysaccharide (LPS)-induced acute lung injury (ALI).Methods: Mice were pretreatment with aloin 1 h before LPS administration. The number of inflammatory cells and the levels of TNF-α and IL-1β was detected. The lung histopathological changes, wet/dry ratio, MPO activity, GSH, MDA, SOD
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Phenotypic analysis of tumor-infiltrating lymphocytes from non-small cell lung cancer and their potential application for adoptive cell therapy. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-05-18 Yipeng Ma,Jiayu Ou,Tong Lin,Lei Chen,Juntao Wang,Dongjuan Qiao,Shuoyan Lai,Chaojun Duan,Yuanda Cheng,Ruimin Chang,Chunfang Zhang,Mingjun Wang
Aim: Adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TILs) has demonstrated clinical benefits in metastatic melanoma treatment. However, the clinical application of TILs produced by a widely used standard protocol from non-small cell lung cancer (NSCLC) can be quite challenging because of the limited clinical benefits. A comprehensive phenotypic knowledge of TILs obtained from NSCLC
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Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-05-12 Tomoshi Sugiyama,Miyoko Matsushima,Tomoko Ohdachi,Naozumi Hashimoto,Yoshinori Hasegawa,Kohei Yokoi,Tsutomu Kawabe
Aim: Acute rejection is still a major problem in transplantation and one of the most important causes of late graft loss. Cyclosporine and tacrolimus are widely used for suppression of T cell function to avoid graft rejection, but long-term use of these compounds is associated with serious toxicities. Quercetin, a flavonoid found in fruits and vegetables, has been demonstrated to exhibit cytoprotective
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The expression of thioredoxin-1 and inflammatory cytokines in patients with sepsis. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-04-23 Ruifei Shao,Yan Yang,Yixin Zhang,Shimin Zhao,Zhirong Zheng,Guobing Chen
Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Inflammatory response and oxidative stress play an important role in the pathophysiological process of sepsis. Thioredoxin-1 (Trx-1) is a small ubiquitous thiol protein with redox/inflammation modulatory properties relevant to the pathogenesis of sepsis. We therefore investigated the expression
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Protective effect of dapsone against renal ischemia-reperfusion injury in rat. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-04-23 Sadaf Nezamoleslami,Mohammad Sheibani,Fatemeh Jahanshahi,Faiza Mumtaz,Ata Abbasi,Ahmad Reza Dehpour
Background: Ischemia/reperfusion can cause injury to tissues and compromise functionality of organs due to inflammatory processes. Significantly, development of these effects in kidney tissue has been a challenging issue that leads to acute renal injury. In this study, anti-inflammatory, anti-oxidative, and protective features of dapsone on kidney ischemia/reperfusion injury were investigated.Material
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Ketoprofen hypersensibility and idiosyncratic response - a case report. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-02-21 Marcio Antonio Rodrigues Araujo
Context: Ketoprofen is widely used to remove pain. A steady increase on allergic reactions and photoallergic contact dermatitis related to ketoprofen has been reported when there is topical use. However, there are few documented cases of hypersensitivity when it is administered systemically.Objective: Present a case of hypersensitivity reaction after systemic administration of ketoprofen for pain control
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The potential hepatoprotective effects of lovastatin combined with oral hypoglycemic agents in streptozotocin-induced diabetes in rats. Immunopharmacol. Immunotoxicol. (IF 2.352) Pub Date : 2020-03-02 Souty M Z Sharkawi,Ehab A M El-Shoura,Amira M Abo-Youssef,Ramadan A M Hemeida
Aims: Epidemiologic studies have shown that individuals with diabetes have a higher risk of hepatic diseases which represent a true clinical problem. The purpose of the present study was to assess the possible modulatory effect of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor lovastatin on therapeutic efficiency of traditional antidiabetics, as metformin and gliclazide, regarding