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T-Cell Metabolism in Rheumatoid Arthritis: Focus on Mitochondrial and Lysosomal Dysfunction Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-03-13 Asmita Parab, Lokesh Kumar Bhatt
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune cell dysregulation, synovial hyperplasia, and progressive cartilage destruction. The loss of immunological self-t...
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Immunosuppressants against acute kidney injury: what to prefer or to avoid? Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-03-13 Swati Mishra, Vishwadeep Shelke, Neha Dagar, Maciej Lech, Anil Bhanudas Gaikwad
Acute kidney injury (AKI) is a significant global health concern with high mortality rates. Patients who undergo renal transplants and other major surgeries are at a heightened risk of developing A...
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Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-03-11 Jia Jian, Li Yu-qing, Han Rang-yue, Zhong Xia, Xie Ke-huan, Yan Ying, Wang Li, Tan Rui-zhi
Objective: Isorhamnetin (IH) has been reported to have significant anti-inflammatory effects in various diseases, but its role and mechanism in AKI remain unclear. This study aimed to explore the p...
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Correction Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-02-07
Published in Immunopharmacology and Immunotoxicology (Ahead of Print, 2024)
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What factors may affect the effect of ICI-combined therapy in patients with metastatic renal cell carcinoma? A meta-analysis Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-02-06 Haiyang Yan, Zhaohui Xing, Shuai Liu, Peng Gao, Guiying Guo
Objective: The prognostic factors of ICI-including combined therapy in patients with metastatic renal cell carcinoma were analyzed by systematic review.Method: We searched Web of Science, Cochrane,...
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Sirtuins: Exploring Next-Gen Therapeutics in the pathogenesis Osteoporosis and Associated Diseases Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-02-06 Tejal R. Waykar, Satish K. Mandlik, Deepa S. Mandlik
Osteoporosis poses a substantial public health challenge due to an ageing population and the lack of adequate treatment options. The condition is marked by a reduction in bone mineral density, resu...
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The effect of Vortioxetine on the NLRP3 pathway and microglial activity in the prefrontal cortex in an experimental model of depression Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-29 Gulin Ozdamar Unal, Duygu Kumbul, Kuyas Hekimler Ozturk, Gamze Erkılınc, Feyza Donmez, Eltaf Dogan Kıran, Ramazan Oğuz Yuceer
Increasing evidence suggests that early life stress (ELS) and neuroinflammation are associated with the pathophysiology of depression. The purpose of this study was to determine the effects of Vort...
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The protective effect of Teprenone in TNBS-induced ulcerative colitis rats by modulating the gut microbiota and reducing inflammatory response Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-22 Jianfeng Yao, Tao Sun, Songbai Zheng, Jianxia Ma, Qinglian Zeng, Kangwei Liu, Wei Zhang, Yang Yu
Ulcerative colitis (UC), a chronic and refractory non-specific inflammatory bowel disease, affects millions of patients worldwide and increases the risk of colorectal cancer. Teprenone is an acylic...
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Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-21 Ling-Jung Yen, Ying-Chin Chen, Kai-Chun Wang, Meng-Chieh Shih, Chia-Ling Li, Sheng-Jie Yu, Ling-Ying Lu
Hydroxychloroquine (HCQ) is a US Food and Drug Administration (FDA)-approved treatment for systemic lupus erythematosus (SLE) through inhibition of antigen presentation and subsequent reduction in ...
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The transcriptomic profile shows the protective effects of celecoxib on cirrhotic splenomegaly Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-21 Yanting Ye, Shihang Tang, Yang Tai, Chong Zhao, Chengwei Tang, Zhiyin Huang, Jinhang Gao
Splenomegaly can exacerbate liver cirrhosis and portal hypertension. We have previously demonstrated that cyclooxygenase-2 (COX-2) inhibitor can attenuate cirrhotic splenomegaly. However, the mecha...
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Cynarin ameliorates dextran sulfate sodium-induced acute colitis in mice through the STAT3/NF-κB pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-21 Shumin Chen, Shaoshuai Tang, Chunbin Zhang, Yuanyue Li
Cynarin is a derivative of hydroxycinnamic acid presented in various medicinal plants, such as Cynara scolymus L. and Onopordum illyricum L. To date, the antioxidant and antihypertensive activities...
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Prediction of prognostic and immune therapy response in lung adenocarcinoma based on MHC-I-related genes Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-21 Hangdi Xu, Yanjie Hu, Xiuming Peng, Enguo Chen
The study investigated the prognostic and immune predictive potential of major histocompatibility complex class I (MHC-I) in lung adenocarcinoma (LUAD).With The Cancer Genome Atlas (TCGA)-LUAD and ...
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Ivermectin ameliorates bleomycin-induced lung fibrosis in male rats by inhibiting the inflammation and oxidative stress Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-15 Fatemeh Habibi Razi, Razieh Mohammad Jafari, Mohammad Amin Manavi, Mohammad Sheibani, Amir Rashidian, Seyed Mohammad Tavangar, Mohammad Taghi Beighmohammadi, Ahmad Reza Dehpour
Idiopathic pulmonary fibrosis (IPF) is a pulmonary fibrotic disease characterized by a poor prognosis, which its pathogenesis involves the accumulation of abnormal fibrous tissue, inflammation, and...
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Cycloastragenol restrains keratinocyte hyperproliferation by promoting autophagy via the miR-145/STC1/Notch1 axis in psoriasis Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-09 Jie Xia, Yuan Zhang, Qing Wang, Teng Zhang
Psoriasis is characterized by inflammation and hyperproliferation of epidermal keratinocytes. Cycloastragenol (CAG) is an active molecule of Astragalus membranaceus that potentially plays a repress...
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Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2024-01-04 Pengfei Zhu, Xingyu Bi, Dan Su, Xiaoling Li, Bingbing Chen, Juhua Li, Lijiang Zhao, Yaoqing Wang, Suming Xu, Xueqing Wu
Objective: The activation of the NLRP3 inflammasome has been implicated in male infertility. Our study aimed to investigate the therapeutic role of Thiolutin (THL), an inhibitor of the NLRP3 inflam...
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Hydroxychloroquine ameliorates immune functionality and intestinal flora disorders of IgA nephropathy by inhibition of C1GALT1/Cosmc pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-27 Chaochao Wang, Xiaoqiao Cai, Shengfen Lin, Yongqiang Lin
Background: Hydroxychloroquine (HCQ) has emerged as a potential and secure antiproteinuric agent in Ig A nephropathy (IgAN). This study endeavored to explore the impact of HCQ on the immune functio...
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Celecoxib Alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-29 Yaxian Li, Mengdi Ma, Xiaodong Wang, Jing Li, Ziqing Fang, Jianhui Li, Bo Yang, Yida Lu, Xin Xu, Yongxiang Li
Introduction: Ulcerative colitis (UC) is an inflammatory intestine disease characterized by dysfunction of the intestinal mucosal barrier, ferroptosis, and apoptosis. Previous researches suggest th...
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AFM1 Exposure in Male Balb/c Mice and Intervention Strategies Against Its Immuno-physiological toxicity using Clay Mineral and Lactic Acid Bacteria Alone or in Combination Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-27 Amina Aloui, Jalila Ben Salah-Abbès, Hela Belgacem, Haifa Dhif, Abdellah Zinedine, Amar Riba, Jean Christophe Meile, Noel Durande, Catherine Brabet, Samir Abbès
Aflatoxins are the most harmful mycotoxins that cause human and animal health concerns. Aflatoxin M1 (AFM1) is the primary hydroxylated metabolite of aflatoxin B1 and is linked to the development o...
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Eosinophil to lymphocyte ratio may predict OCS reduction and change in quality of life (AQLQ) resulting from asthma biological treatment Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-27 Olga Branicka, Radosław Gawlik Prof, Joanna Glück Prof
Simple clinical parameters that could be helpful in choice of monoclonal antibodies and prediction of their effectiveness are being sought. The aim was to assess if neutrophil-to-lymphocyte, eosino...
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Endoplasmic reticulum stress is upregulated in inflammatory bowel disease and contributed TLR2 pathway-mediated inflammatory response Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-26 Weijie Wu, Yan Zhao, Tian Hu, Yan Long, Ya Zeng, Mengling Li, Siyuan Peng, Jinyue Hu, Yueming Shen
Endoplasmic reticulum stress (ERS) and Toll-like receptor 2 (TLR2) signaling play an important role in inflammatory bowel disease (IBD); however, the link between TLR2 and ERS in IBD is unclear. Th...
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Time to treat the climate and nature crisis as one indivisible global health emergency Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-05 Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E. Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
Published in Immunopharmacology and Immunotoxicology (Vol. 45, No. 6, 2023)
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Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-12-05 Mukaddes Esrefoğlu, Tugce Kubra Kalkan, Ersin Karatas, Birsen Elibol, E. Rumeysa Hekimoglu, Fatma Bedia Karakaya Cimen, Arzu Hanim Yay
One of the serious complications of sepsis is liver damage and liver failure. This study aimed to evaluate the protective and therapeutic potential of melatonin in rats with lipopolysaccharide-indu...
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The potential role of hydrogen sulfide in regulating macrophage phenotypic changes via PINK1/parkin-mediated mitophagy in sepsis-related cardiorenal syndrome Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-11-16 Yuxuan Chen, Wei Cao, Bin Li, Xiaofei Qiao, Xiangdong Wang, Guang Yang, Siying Li
Objective: Sepsis is one of major reasons of cardiorenal syndrome type 5 (CRS-5), resulting in irreversible tissue damage and organ dysfunction. Macrophage has been demonstrated to play key role in...
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Songorine inhibits oxidative stress-related inflammation through PI3K/AKT/NRF2 signaling pathway to alleviate lipopolysaccharide-induced septic acute lung injury Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-11-17 Jingjing Fang, Qin Huang, Chaolu Shi, Lei Gai, Xinnian Wang, Biqing Yan
The present study aimed to investigate the protective action and mechanism of songorine on sepsis-induced acute lung injury (ALI).The sepsis-induced ALI mouse and cell models were established by li...
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Gigantol protects retinal pigment epithelial cells against high glucose-induced apoptosis, oxidative stress and inflammation by inhibiting MTDH-mediated NF-kB signaling pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-09-08 You Chen, Tong Zhao, Mengyu Han, Yi Chen
As a frequent complication of diabetes mellitus (DM), diabetic retinopathy (DR) is now one of the major causes of blindness. Recent reports have shown that retinal pigment epithelial cell (RPEC) da...
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Expression of calcitonin gene-related peptide in atopic dermatitis and correlation with distress Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-09-07 Saly Abdelhadi, Klas Nordlind, Björn Johansson, Elvar Theodorsson, Mikael Holst, Louise Lönndahl
Atopic dermatitis (AD) is a chronic, inflammatory, often severely itching skin disorder. It may worsen due to stress, depression, or anxiety. Calcitonin gene-related peptide (CGRP) may be involved ...
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Withaferin A suppressed hepatocellular carcinoma progression through inducing IGF2BP3/FOXO1/JAK2/STAT3 pathway-mediated ROS production Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-09-06 Jinhai Li, Mengchen Ge, Pengcheng Deng, Xinquan Wu, Longqing Shi, Yu Yang
This study aimed to investigate the underlying molecular mechanisms of Withaferin A (WA) in hepatocellular carcinoma (HCC).The gene and protein expression were analyzed using RT-qPCR and western bl...
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Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-09-06 Dilek Çevik, Nurhan Gümral, Rahime Aslankoç, Özlem Özmen, Arzu Yalçın, Oğuzhan Kavrık
We investigated the protective effects of pregabalin (PRG) on kidney and renal endothelial damage in sepsis induced by Lipopolysaccharide (LPS).Rats were randomly divided into three groups as contr...
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Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-09-04 Zhiming Wu, Qin Liu, Zhengliu Cao, Hui Li, Yifen Zhou, Peng Zhang
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation and joint damage, leading to pain and reduced joint function. Icariin, a flavonoid compound, has been studi...
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Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-30 Pedram Basirjafar, Raziyeh Zandvakili, Javad Masoumi, Nahid Zainodini, Zahra Taghipour, Hossein Khorramdelazad, Soheila Yousefi, Tayyebeh Tavakoli, Mahboobeh Vatanparast, Sepehr Safdel, Mahsa Gheitasi, Fatemeh Ayoobi, Bahar Naseri, Abdollah Jafarzadeh
In dendritic cells (DCs), leptin as an immune-regulating hormone, increases the IL-12 generation whereas it reduces the IL-10 production, thus contributing to TH1 cell differentiation. Using a muri...
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Effects of erucin on inflammatory mediators and antioxidant enzymes’ expression in TNF-α-stimulated human oral epithelial cells Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-30 Masahiro Shimoyama, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Keiichi Hosaka
Periodontitis is a chronic inflammatory disease induced by periodontal disease-causing bacteria. It has been shown that excessive immune response against bacteria is involved in periodontal tissue ...
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Ciclopirox mitigates inflammatory response in LPS-induced septic shock via inactivation of SORT1-mediated wnt/β-Catenin signaling pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-22 Liangliang Zhou, Yingfeng He, Yijun Deng, Xinxin Li, Wei Wang, Jianjun Chen
Septic shock, the most severe stage of sepsis, is a deadly inflammatory disorder with high mortality. Ciclopirox (CPX) is a broad-spectrum antimycotic agent which also exerts anti-inflammatory effe...
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Macrophages morphology and cytokine reeducation by ex situ copper thiol complexes Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-16 Jorge Xool-Tamayo, Víctor Ermilo Arana-Argaez, Fabiola Villa-de la Torre, Ivan Chan-Zapata, Rossana F. Vargas-Coronado, Juan V. Cauich-Rodríguez
To study the reeducation effect of copper thiol complexes on macrophage morphology and cytokine expression.The effect of copper thiol complexes was assessed on murine macrophages by the cell morpho...
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mTORC1 inhibition may improve T lymphocytes affected by aging Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-15 F. Asghari, M. H. Karimi, A. A. Pourfathollah
Due to the increase of the elderly’s population and related social and economic problems, it is very important to provide strategies on health. In this regard, induction of T lymphocytes responses,...
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HIV protease inhibitor saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-07 Kai Yao, Zheng Wang, Cheng Peng, Yong Wang, Bichen Xue, Yulin Tang, Zhichao Wang, Hongbo Xu
Toll-like receptor 4 (TLR4) is crucial in induction of innate immune response through recognition of invading pathogens or endogenous alarming molecules. Ligand-triggered dimerization of TLR4 is es...
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Immunomodulatory effect of vitamin D supplementation on Behçet’s disease patients: effect on nitric oxide and Th17/Treg cytokines production Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-03 Randa Oubouchou, Zineb Ait Arab -Djeraba, Yassmine Kemikem, Fifi Otmani, Chafia Touil-Boukoffa
In the last decade, an immuno-modulatory effect of vitamin D supplementation have emerged as a potential therapeutic approach for some inflammatory and autoimmune diseases. As previously reported, ...
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Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF-κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-03 Hanaa M. Tashkandi, Hanan S. Althagafy, Fatima A. Jaber, Turki Alamri, Nouf S. Al-Abbas, Nehad A. Shaer, Steve Harakeh, Emad H. M. Hassanein
Methotrexate (MTX) is an antimetabolite agent widely used to manage a variety of tumors and autoimmune diseases. Nonetheless, MTX-induced intestinal intoxication is a serious adverse effect limitin...
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Cancer-associated immune cells and their modulation by melatonin Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-08-03 Shirin Hekmatirad, Milad Moloudizargari, Marjan Fallah, Atena Rahimi, Vahdat Poortahmasebi, Mohammad Hossein Asghari
Rapidly growing evidence suggests that immune cells play a key role in determining tumor progression. Tumor cells are surrounded by a microenvironment composed of different cell populations includi...
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Forkhead box A1 induces angiogenesis through activation of the S100A8/p38 MAPK axis in cutaneous wound healing Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-17 Zhongzhi Zhou, Meilin Zou, Hongping Chen, Furong Zhu, Tingting Wang, Xinling Huang
The association between S100 calcium-binding protein A8 (S100A8) and angiogenesis has been reported in previous reports. This study focuses on the roles of S100A8 in the angiogenesis of human derma...
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Leukoreduced PRP enhanced proliferation and ECM production yet inhibited senescence, inflammation, and multi-differentiation potential of AFSCs by downregulating HMGB1 Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-12 Baoshan Hu, Lianxin Wang, Naikun Sun, Gang Rui, Shengrong Lin
This study assessed the role and potential mechanism of platelet-rich plasma (PRP) in the progression of intervertebral disk degeneration (IVDD).Annulus fibrosus (AF)-derived stem cells (AFSCs) fro...
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Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-07 Xiulian Zhang, Xueliang Li, Wei Ma, Fangying Liu, Pinxian Huang, Lei Wei, Li Li, Yechang Qian
Chronic obstructive pulmonary disease (COPD) has a high fatality rate and poses a great threat to human health. Astragaloside IV (AS-IV) is proven to attenuate cigarette smoke (CS)-induced pulmonar...
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CD26 CAR-T cells have attenuated mitochondrial and glycolytic metabolic profiling Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-06 Xiaoying Zhu, Zhaodong Zhong, Fankai Meng, Ping Zou, Yong You, Qing Li, Xiaojian Zhu
Multiple targets of chimeric antigen receptor T cells (CAR-T cells) are shared expressed by tumor cells and T cells, these self-antigens may stimulate CAR-T cells continuously during the expansion....
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Sufentanil inhibits the metastasis and immune response of breast cancer via mediating the NF-κB pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-06 Mingming Li, Kuo Gu, Qingling Kong, Guonian Wang, Jing Gu
Breast cancer (BC) causes cancer-related death in women. Sufentanil is used for cancer pain and postoperative analgesia. This study aimed to explore the role of sufentanil in BC.BC cells were treat...
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TNF-α promotes CXCL-1/8 production in keratinocytes by downregulating galectin-3 through NF-κB and hsa-miR-27a-3p pathway to contribute psoriasis development Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-03 Xiao-nan Qiu, Dan Hong, Zhen-rui Shi, Si-yao Lu, Yu-xian Lai, Yan-ling Ren, Xiu-ting Liu, Chi-peng Guo, Guo-zhen Tan, Liang-chun Wang
Treatment with TNF-α inhibitors improve psoriasis with minimize/minor neutrophils infiltration and CXCL-1/8 expression in psoriatic lesions. However, the fine mechanism of TNF-α initiating psoriati...
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A case report and literature review on respiratory failure with immune checkpoint inhibitors: a life-threatening adverse event Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-03 Xinqing Lin, Wenhui Guan, Bingliang Li, Haiyi Deng, Yan Chen, Yiling Yang, Guihuan Qiu, Xiaohong Xie, Chengzhi Zhou
Neuromuscular associated respiratory failure is a rare toxicity of immunotherapy for malignant tumors. In most cases, it may overlap with the symptoms of the primary disease or myocarditis, myositi...
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Secreted phosphoprotein 1 regulates natural compound 3’,4’,5,7-tetrahydroxyflavone to inhibit mast cell-mediated allergic inflammation Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-07-03 Shiling Hu, Jue Wang, Haoyun Bai, Chaohua Feng, Zhenqi Zhou, Zhuoyin Xue, Wen Zhang, Yongjing Zhang, Nan Wang, Langchong He
Mast cells (MCs) are important effector cells in anaphylaxis and anaphylactic disease. 3’,4’,5,7-tetrahydroxyflavone (THF) presents in many medicinal plants and exerts a variety of pharmacological ...
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Targeting the cGAS-STING pathway as an inflammatory crossroad in coronavirus disease 2019 (COVID-19) Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-06-19 Reza Elahi, Salar Hozhabri, Amirhosein Moradi, Amir Siahmansouri, Armin Jahani Maleki, Abdolreza Esmaeilzadeh
The emerging pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has imposed significant mortality and morbidity on the world. A...
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Molecular mechanisms mediate roflumilast protective effect against isoprenaline-induced myocardial injury Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-06-19 Marwa Monier Mahmoud Refaie, Manar Fouli Gaber Ibrahim, Michael Atef Fawzy, Elshymaa A. Abdel-Hakeem, Eman Shaaban Mahmoud Abd El Rahman, Nagwa M. Zenhom, Sayed Shehata
Myocardial necrosis is one of the most common cardiac and pathological diseases. Unfortunately, using the available medical treatment is not sufficient to rescue the myocardium. So that, we aimed i...
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Knockdown of A20 attenuates microglial susceptibility to OGD/R-induced ferroptosis and upregulates inflammatory responses Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-06-06 Xiaorong Liu, Xiaomei Jin, Xianhui Wang, Xiaodan Yan, Chi Wang, Kaiyue Wang, Xiaoyan He, Wanqing Zhai
The A20 protein is considered to have a potent anti-inflammatory effect, but its mechanism of action in the regulation of ferroptosis and inflammation after stroke is still unknown. In this study, ...
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Efficacy and safety of the combined use of ipilimumab and nivolumab for melanoma patients with brain metastases: a systematic review and meta-analysis Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-05-25 Mengmeng Su, Yuyan Yang, Peng Wang
Immune checkpoint inhibitors have advanced immunotherapy for melanoma patients.Objective: This study evaluates efficacy and safety of ipilimumab and nivolumab combination (IN) for melanoma brain me...
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Efficacy and safety of immune checkpoint inhibitors combined with anti-VEGF therapy in the treatment of unresectable or advanced liver cancer: a systematic review Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-05-25 Wenchao Yang, Xiaofang Li, Jiana He, Qingqing Xuan, Haiyan Si, Weifen Yao
This study aimed to evaluate the clinical effects and safety of immune checkpoint inhibitors (ICIs) combined with anti-VEGF therapy for the treatment of unresectable or advanced liver cancer.Relate...
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The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-26 Mina Djalali, Sepide Talebi, Ehsan Djalali, Mina Abdolahi, Nikolaj Travica, Mahmoud Djalali
Imbalances in immune regulation are important features of migraine pathophysiology. In line with this, the current study investigated the efficacy of omega-3 fatty acids supplementation on inflamma...
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Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-20 Marwa M. M. Refaie, Maram El-Hussieny, Sayed Shehata, Nermeen N. Welson, Walaa Yehia Abdelzaher
Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its clinical use is challenged by various types of injuries, including hepatotoxic side effects. Therefore, finding new protec...
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Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-20 Zeinab Faghfoori, Zeinab Javadivala, Yeganeh Khalili, Aida Malek Mahdavi
Adjuvant therapies especially medicinal plants have gained lots of attention nowadays and have been consumed all over the world for treating different diseases particularly rheumatoid arthritis (RA...
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Imperatorin inhibits LPS-induced bone marrow-derived macrophages activation by decreased NF-κB p65 phosphorylation Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-11 Yuan Jiang, Hui Fang, Siqi Lin, Yunyun Chen, Yuanzheng Fu, Yifan Tu, Qiang Li, Zhaoyuan Hui
Imperatorin (IMP) is a secondary metabolite of plants and is the most abundant in Angelica dahurica. Previous studies showed that IMP exhibited anti-inflammatory activity in RAW264.7 cell line. Her...
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Two flavonoids, baicalein and naringin, are effective as anti-inflammatory and anti-oxidant agents in a rat model of polymicrobial sepsis Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-11 Pinar Bayram, Selina Aksak Karamese, Bengul Ozdemir, Cagatay Salum, Huseyin Serkan Erol, Murat Karamese
In this study, our aim was to investigate the possible protective and therapeutic effects of these two flavonoids, baicalein, and naringin, in 50 and 100 mg/kg doses applied both before and after c...
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Phloroglucinol possesses anti-inflammatory activities by regulating AMPK/Nrf2/HO-1 signaling pathway in LPS-stimulated RAW264.7 murine macrophages Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-11 Chathuri Kaushalya Marasinghe, Won-Kyo Jung, Jae-Young Je
Inflammation is closely related to the pathogenesis of chronic illnesses. Secondary metabolites of marine seaweeds are recognized as reliable sources of bioactive compounds due to their health bene...
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Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1 Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-04-05 Eri Asami, Megumi Kitami, Takako Ida, Tadaharu Kobayashi, Makio Saeki
2-Methoxy-4-vinylphenol (2M4VP) is a natural anti-inflammatory compound derived from red wine, but its underlying mechanism remains unclear. Heme oxygenase-1 (HO-1), an anti-inflammatory enzyme, in...
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Correction Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-03-27
Published in Immunopharmacology and Immunotoxicology (Vol. 45, No. 5, 2023)
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IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway Immunopharmacol. Immunotoxicol. (IF 3.3) Pub Date : 2023-03-27 Xiaoyu Chen, Xunxia Zhu, Xiaoyong Shen, Yang Liu, Wentao Fu, Bin Wang
Abstract Objectives The tumor-promoting function of IGF2BP3 has been reported in several cancers. The present study aimed to explore the function and molecular mechanisms of IGF2BP3 are elusive in lung adenocarcinoma (LUAD). Methods IGF2BP3 expression in LUAD and its prognostic value were estimated by bioinformatics. RT-qPCR was employed to detect the expression of IGF2BP3 and confirm the transfection