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Sympathetic-immune interactions during different types of immune challenge. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-11-26 Adriana Del Rey,Hugo Besedovsky
BACKGROUND The neuro-endocrine regulation of immune functions is based on a complex network of interactions. As part of this series of articles, we refer here to immune-sympathetic interactions that are triggered by different types of immune challenge. SUMMARY We mention the initial hypothesis that led to the proposal that the sympathetic nervous system (SNS) is involved in immunoregulation. We next
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Olfactory cues of naturally occurring systemic inflammation: A pilot study of seasonal allergy. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-11-16 Arnaud Tognetti,Supreet Saluja,Nathalie Lybert,Julie Lasselin,Sandra Tamm,Catarina Lensmar,Bianka Karshikoff,Simon Cervenka,Mats Lekander,Mats J Olsson
INTRODUCTION In an attempt to avoid contact with infectious individuals, humans likely respond to generalised rather than specific markers of disease. Humans may thus perceive a non-infectious individual as socially less attractive if they look (e.g., have facial discoloration), move (e.g., have a slower walking pace), or sound (e.g., sneeze) sick. This pilot study tested whether humans are averse
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Ageing affects thymopoiesis and EAE development in a strain-dependent manner. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-11-10 Zorica Stojić-Vukanić,Marija Petrušić,Ivan Pilipović,Gordana Leposavić
INTRODUCTION Considering significance of mechanisms of central tolerance for development of autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), and suppressive influence of circulating proinflammatory cytokines and alterations in brain-thymus communication characteristic for the central nervous system (CNS) autoimmune diseases, the study was undertaken to identify putative
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Inhibition of galectin-3 in a rat model of epilepsy and kainate-activated BV-2 cells limits microglial activation through NLRP3/pyroptosis pathway. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-11-03 Weiwei Sun,Ying Hao,Chunxiang Li,Yuanyuan Zhao,Haishao Yu,Lin Wang
INTRODUCTION This study aimed to investigate the possible role of galectin-3 in epilepsy and further explore its underlying mechanisms. METHODS Sprague-Dawley rats were intraperitoneally injected with 30 mg/kg pilocarpine to induce an animal model of epilepsy. To inhibit galectin-3, the epilepsy model of rats was intraperitoneally injected with TD139. The severity of the seizure was graded according
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Transcrocetin meglumine salt inhibits spinal glial cell-mediated proinflammatory cytokines and attenuates complete Freund's adjuvant-induced inflammatory pain. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-10-27 Qing Qiao,Dandan Yao,Yongjie Wang,Shuxia Zhang,Gang Chen
INTRODUCTION Inflammatory pain is a significant global clinical challenge that involves both unpleasant sensory and emotional experiences. The treatment of pain is imminent, and we are committed to seeking new analgesics for pain relief. Transcrocetin meglumine salt (TCMS), a saffron metabolite derived from the crocin apocarotenoids, has exhibited the ability to cross the blood-brain barrier and exert
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Chronic Stress Exacerbates Hyperglycemia-Induced Affective Symptoms in Male Mice. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-10-18 Riley G McCready,Kayla R Gilley,Laura E Kusumo,Grace M Hall,Elisabeth G Vichaya
INTRODUCTION Among chronically ill populations, affective disorders remain underdiagnosed and undertreated. A high degree of comorbidity exists between diabetes and affective disorders, particularly depression and anxiety. The mechanisms underlying stress-induced affective dysregulation are likely distinct from that induced by diabetes. A direct comparison between stress- and hyperglycemia-induced
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Age-dependent Effects of Transgenic 2D2 Mice Used to Induce Passive EAE in C57BL/6 Mice. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-10-12 James M Nichols,Barbara L F Kaplan
INTRODUCTION Multiple sclerosis (MS) is a neurodegenerative autoimmune disease which worsens with age. Here we examined the influence of age on passive experimental autoimmune encephalomyelitis (P-EAE), a model to study MS, using young and mature adult 2D2 transgenic donor mice to induce pathology in WT C57BL6/J mice. METHODS Lymphocytes from young adult (i.e., 10-week-old) or mature adult (i.e., 6-month-old)
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How can experimental endotoxemia contribute to our understanding of pain? A narrative review. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-10-05 Sven Benson,Bianka Karshikoff
BACKGROUND The immune system and the central nervous system exchange information continuously. This communication is a prerequisite for adaptive responses to physiological and psychological stressors. While the implicate relationship between inflammation and pain is increasingly recognized in clinical cohorts, the underlying mechanisms and the possibilities for pharmacological and psychological approaches
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Endotoxin-induced physiological and psychological sickness responses in healthy humans: insights into the post-acute phase. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-10-05 Harald Engler,Alexandra Brinkhoff,Benjamin Wilde,Andreas Kribben,Hana Rohn,Oliver Witzke,Manfred Schedlowski,Sven Benson
INTRODUCTION Experimental endotoxemia is a translational model of systemic inflammation that has contributed significantly to our current understanding of sickness behavior and inflammation-associated depression. Previous studies using this model revealed a strong association between cytokine levels, endocrine changes, and psychological sickness symptoms during the acute phase of inflammation. The
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Olfactory bulbs in arthritis model mouse persistently express interleukin-6 before the onset of arthritis: Relationship to food intake. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-09-28 Kazuhiro Otani,Masayuki Yoshiga,Masashi Hirano,Takayuki Matsushita,Kentaro Noda,Daitaro Kurosaka
Introduction Rheumatoid arthritis (RA) can be comorbid with psychiatric symptoms. Brain abnormalities in RA patients and in arthritis models have been reported. However, it remains unclear when these abnormalities occur and where they are distributed. In this study, we analyzed spatiotemporal changes in gene expression in the brains of mice with collagen-induced arthritis (CIA). Methods Mice were divided
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Neuropsychiatric outcomes and sleep dysfunction in COVID-19 patients: risk factors and mechanisms. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-09-27 Aliki Karkala,Asterios Tzinas,Seraphim Kotoulas,Athanasios Zacharias,Evdokia Sourla,Athanasia Pataka
The ongoing global health crisis due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has significantly impacted all aspects of life. While the majority of early research following coronavirus disease caused by the SARS-CoV-2(COVID-19) has focused on the physiological effects of the virus, a substantial body of subsequent studies has shown that the psychological burden of the
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Modulation of neuroinflammation: advances in roles and mechanisms of IL-33/ST2 axis involved in ischemic stroke. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-09-20 Shuang Guo,Chengli Qian,Wenfeng Li,Zhikun Zeng,Junlong Cai,Yi Luo
Interleukin (IL)-33 was initially recognized as a constituent of the IL-1 cytokine family in 2005. It exerts pleiotropic effects by regulating immune responses via its binding to the receptor ST2 (IL-33R). The IL-33/ST2 pathway has been linked to several inflammatory disorders. In human and rodents, the broad expression of IL-33 in spinal cord tissues and brain indicates its central nervous system
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Hypothalamic-pituitary axis function and adrenal insufficiency in COVID-19 patients. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-09-13 Emre Durcan,Aysa Hacioglu,Zuleyha Karaca,Kursad Unluhizarci,Mustafa Sait Gonen,Fahrettin Kelestimur
The outbreak of COVID-19 has affected more than half a billion people worldwide and caused more than 6 million deaths since 2019. The responsible virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affects the lungs, but it has multisystemic effects. It is well known that dysfunction of multiple endocrine organs may occur during or after COVID-19. Impairment of hypothala
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Effect of leuprolide acetate, a GnRH agonist, on neuroinflammation and anxiety-like behavior after mild hypoxic-ischemic encephalopathy in rat model. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-08-22 Karina Alejandra Pedroza-García,Denisse Calderón-Vallejo,Daniel Cervantes-García,Andrés Quintanar-Stephano,Eva Salinas,J Luis Quintanar
BACKGROUND Mild hypoxic-ischemic encephalopathy (HIE) is a condition that predisposes to negative outcomes such as neuroanatomical injury, mood disorders, and motor or cognitive disabilities. The neuroinflammation plays an important role in the neurological damage, therefore reducing it could provide neuroprotection. The leuprolide acetate (LA) has shown to have neuroregenerative and immunomodulator
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2nd European Psychoneuroimmunology Network (EPN) Autumn School: The skin-brain axis and the breaking of barriers. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-08-17 Eva Peters
none.
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Understanding the immune-endocrine effects of vitamin D in SARS-CoV-2 infection: a role in protecting against neurodamage? Neuroimmunomodulation (IF 2.4) Pub Date : 2023-08-09 Emanuele Gotelli,Stefano Soldano,Elvis Hysa,Andrea Casabella,Andrea Cere,Carmen Pizzorni,Sabrina Paolino,Alberto Sulli,Vanessa Smith,Maurizio Cutolo
Calcitriol and hydroxyderivatives of lumisterol and tachisterol are secosteroid hormones with immunomodulatory and anti-inflammatory properties. Since the beginning of the COVID-19 pandemic, several studies have correlated deficient serum concentrations of vitamin D3 (calcifediol) with increased severity of the course of SARS-CoV-2 infection. Among systemic complications, subjective (anosmia, ageusia
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Role of the sympathetic nervous system in mild chronic inflammatory diseases - focus on osteoarthritis. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-07-10 Rebecca Sohn,Zsuzsa Jenei-Lanzl
The sympathetic nervous system (SNS) is a major regulatory mediator connecting the brain and the immune system that influences accordingly inflammatory processes within the entire body. In the periphery, the SNS exerts its effects mainly via its neurotransmitters norepinephrine (NE) and epinephrine (E), which are released by peripheral nerve endings in lymphatic organs and other tissues. Depending
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Role of vagus nerve stimulation in the treatment of chronic pain. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-06-27 Peiqi Shao,Huili Li,Jia Jiang,Yun Guan,Xueming Chen,Yun Wang
Vagus nerve stimulation (VNS) can modulate vagal activity and neuro-immune communication. Human and animal studies have provided growing evidence that VNS can produce analgesic effects in addition to alleviating refractory epilepsy and depression. The vagus nerve (VN) projects to many brain regions related to pain processing, which can be affected by VNS. In addition to neural regulation, the anti-inflammatory
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Therapeutic Benefits of Melatonin Against COVID-19. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-06-19 Muhammad Mubashshir,Nabeel Ahmad,Tripti Negi,Renu Rawal,Nirjara Singhvi,Hina Khatoon,Vijya Laxmi,Om Dubey,Renu Bala Sharma,Ganga Negi,Mohd Ovais
The assumption of the pineal hormone melatonin as a therapeutic use for COVID-19 affected people seems promising. It's intake has shown significant improvement in the patients' conditions. Higher melatonin titres in children may provide a protective shield against this disease. The hormone melatonin works as an anti-inflammatory, antioxidant, immunomodulator and strategically slows down the cytokine
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Acute inhibition of inflammation mediated by sympathetic nerves: the inflammatory reflex. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-06-09 Alessandra Occhinegro,Robin M McAllen,Michael J McKinley,Davide Martelli
In this review we will try to convince the readers that the immune system is controlled by an endogenous neural reflex, termed inflammatory reflex, that inhibits the acute immune response during the course of a systemic immune challenge. We will analyse here the contribution of different sympathetic nerves as possible efferent arms of the inflammatory reflex. We will discuss the evidence that demonstrates
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Chronic effects of the sympathetic nervous system in inflammatory models. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-05-18 Georg Pongratz,Rainer H Straub
The immune system is embedded in a network of regulatory systems to keep homeostasis in case of an immunologic challenge. Neuroendocrine immunologic research revealed several aspects of these interactions over the past decades, e.g. between the autonomic nervous system and the immune system. This review will focus on evidence revealing the role of the sympathetic nervous system (SNS) in chronic inflammation
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Autonomic Regulation of Inflammation in Conscious Animals. Neuroimmunomodulation (IF 2.4) Pub Date : 2023-05-05 Helio Salgado Cesar,Fernanda Brognara,Aline Barbosa Ribeiro,Renata Maria Lataro,Jaci Airton Castania,Luis Ulloa,Alexandre Kanashiro
Bioelectronic medicine is a novel field in modern medicine based on specific neuronal stimulation to control organ function and cardiovascular and immune homeostasis. However, most studies addressing neuromodulation of the immune system have been conducted on anesthetized animals, which can affect the nervous system and neuromodulation. Here we review recent studies involving conscious experimental
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Association between the Ile164 β2 Adrenergic Receptor Polymorphism and Fatigue in Patients with Rheumatoid Arthritis Neuroimmunomodulation (IF 2.4) Pub Date : 2023-04-21 Julian Philipp, Christoph G. Baerwald, Olga Seifert
Introduction: In the present work, the frequency of inherited polymorphisms of the beta 2 adrenergic receptor (β2AR) gene and their association with fatigue in patients with rheumatoid arthritis (RA) was examined. Methods: An allele-specific polymerase chain reaction was used to determine the common variants of the β2AR at position 16, 27, and 164 in 92 German RA outpatients. Health Assessment Questionnaire
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Immediate and delayed salivary cytokine responses during repeated exposures to Cold Pressor stress Neuroimmunomodulation (IF 2.4) Pub Date : 2023-03-14 Mauro Larra, Silvia Capellino, Elena Schwendich, Leon von Haugwitz, Jörg Reinders, Edmund Wascher
Introduction Excessive stress is increasingly recognized as an important trigger of many diseases prevalent in modern societies and monitoring such stress related effects could aid prevention. The measurement of salivary markers of inflammation is emerging as a promising tool to non-invasively quantify stress’ effects on immune processes in everyday life and thereby detect early aberrations before
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MiR-124 Reduced Neuroinflammation after Traumatic Brain Injury by Inhibiting TRAF6 Neuroimmunomodulation (IF 2.4) Pub Date : 2023-03-01 Yongxiang Yang, Yuqin Ye, Kexia Fan, Jianing Luo, Yongjian Yang, Yuan Ma
Introduction: Neuroinflammation contributes to secondary injury after traumatic brain injury (TBI), which has been mainly mediated by the microglia. MiR-124 was reported to play an important role in the polarization of microglia by targeting TLR4 signaling pathway. However, the role and mechanism of miR-124 in neuroinflammation mediated by microglia after TBI is unclear. To clarify this, we performed
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Aberrant dendritic cell subsets in patients with myasthenia gravis and related clinical features Neuroimmunomodulation (IF 2.4) Pub Date : 2023-02-13 Yan Song, Chunye Xing, Tianyang Lu, Chen Liu, Wei Wang, Shaoqiang Wang, Xungang Feng, Jianzhong Bi, Qian Wang, Chao Lai
Introduction: Dendritic cells (DCs) play critical roles in the pathogenesis of myasthenia gravis (MG), and a series of DC-based experimental strategies for MG have recently been developed. However, the definite roles of different DC subsets in the mechanism of MG have scarcely been covered by previous studies. The present study aimed to investigate the levels of three main DC subsets, plasmacytoid
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Myrtenol Ameliorates Recognition Memories’ Impairment and Anxiety-Like Behaviors Induced by Asthma by Mitigating Hippocampal Inflammation and Oxidative Stress in Rats Neuroimmunomodulation (IF 2.4) Pub Date : 2023-01-19 Mohammad Abbas Bejeshk, Amir Hashem Aminizadeh, Elham Jafari, Sina Motamedi, Iman Zangiabadi, Ahmad Ghasemi, Mazyar Fathi, Akram Nezhadi, Faezeh Akhgarandouz, Fatemeh Bejeshk, Leila Mohammadi, Fatemeh Mohammadi, Mohammad Amin Rajizadeh
Introduction: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of chronic disorders. Thus, the present research was designed to evaluate the impacts of myrtenol on anxiety-like behaviors, cognitive declines, inflammation
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Integrated Proteomic and Phosphoproteomic Analysis of the Hippocampus in a Mouse Model of Early Life Inflammation Neuroimmunomodulation (IF 2.4) Pub Date : 2023-01-04
Introduction: Inflammation in early life is a risk factor for the development of neuropsychiatric diseases later in adolescence and adulthood, yet the underlying mechanism remains elusive. In the present study, we performed an integrated proteomic and phosphoproteomic analysis of the hippocampus to identify potential molecular mechanisms of early life inflammation-induced cognitive impairment. Methods:
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Neurotensin-Binding Immunoglobulin G in Patients with Parkinson’s Disease Neuroimmunomodulation (IF 2.4) Pub Date : 2022-12-14 Zamira M. Muruzheva, Daniil S. Egorov, Margarita T. Absalyamova, Dmitrii S. Traktirov, Marina N. Karpenko, Serguei O. Fetissov
Introduction: Neurotensin (NTS) is a 13-amino acid neuropeptide functionally linked with the brain dopaminergic system via expression of the NTS peptide or its receptor in dopamine neurons. Neuropeptide-binding immunoglobulins (Igs) are present in humans and can be involved in both physiological and pathological processes. Considering the functional link between NTS and dopamine neurons, we studied
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Acknowledgement to Reviewers Neuroimmunomodulation (IF 2.4) Pub Date : 2022-12-13
Neuroimmunomodulation 2022;29:523
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Contents Vol. 29, 2022 Neuroimmunomodulation (IF 2.4) Pub Date : 2022-12-13
Neuroimmunomodulation 2022;29:I–VI
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The Infected Lungs and Brain Interface in COVID-19: The Impact on Cognitive Function Neuroimmunomodulation (IF 2.4) Pub Date : 2022-11-02 Larissa Joaquim, Amanda Della Giustina, Richard Simon Machado, Kiuanne Lino Lobo Metzker, Sandra Bonfante, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Fabricia Petronilho
Many coronavirus disease 2019 (COVID-19)-recovered patients report signs and symptoms and are experiencing neurological, psychiatric, and cognitive problems. However, the exact prevalence and outcome of cognitive sequelae is unclear. Even though the severe acute respiratory syndrome coronavirus 2 has target brain cells through binding to angiotensin-converting enzyme 2 (ACE2) receptor in acute infection
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Autoantibodies against Central Nervous System Antigens and the Serum Levels of IL-32 in Patients with Schizophrenia Neuroimmunomodulation (IF 2.4) Pub Date : 2022-09-19 Fatemeh Keshavarz, Marziyeh Soltani, Kobra Mokhtarian, Pezhman Beshkar, Jafar Majidi, Fatemeh Azadegan-Dehkordi, Maryam Anjomshoa, Nader Bagheri
Background: Schizophrenia is a disease of the nervous system, and immune system disorders can affect its pathogenesis. Activation of microglia, proinflammatory cytokines, disruption of the blood-brain barrier due to inflammation, activation of autoreactive B cells, and consequently the production of autoantibodies against system antigens are among the immune processes involved in neurological diseases
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1st European Psychoneuroimmunology Network (EPN) Autumn School: Lung-Brain Axis in Health and Disease Neuroimmunomodulation (IF 2.4) Pub Date : 2022-09-01 Christoph Rummel, Adriana del Rey, Leona Bähr, Karsten Krüger, Eva Peters
Neuroimmunomodulation 2022;29(suppl 2):3–8
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1st European Psychoneuroimmunology Network (EPN) Autumn School: Lung-Brain Axis in Health and Disease: Abstracts Neuroimmunomodulation (IF 2.4) Pub Date : 2022-09-01 Christoph Rummel
n/a Neuroimmunomodulation 2022;29:9–34
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1st European Psychoneuroimmunology Network (EPN) Autumn School: Lung-Brain Axis in Health and Disease Neuroimmunomodulation (IF 2.4) Pub Date : 2022-09-01
Neuroimmunomodulation 2022;29:1–2
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Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway Neuroimmunomodulation (IF 2.4) Pub Date : 2022-08-22 Yiqin Lin, Yingle Chen, Jingyang Zeng, Shunyuan Li
Background: Inflammatory pain mediated by nuclear factor kappa-B (NF-κB) signal pathway has become an increasingly important clinical issue in the last decade. As a potent antioxidant, Nodakenetin has been shown to have a prominent inhibitory effect on inflammation. However, the therapeutic effects and underlying pharmacological mechanisms of Nodakenetin for inflammatory pain remain unclear. Methods:
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Vascular Endothelial Growth Factor as a Predictive and Prognostic Biomarker for Multiple Sclerosis Neuroimmunomodulation (IF 2.4) Pub Date : 2022-08-18 Ali Amini Harandi, Fatemeh Siavoshi, Siavash Shirzadeh Barough, Asghar Amini Harandi, Hossein Pakdaman, Mohammad Ali Sahraian, Zahra Fathtabar, Faezeh Mohammadi, Faezeh Karamiani, Seyed Hossein Ardehali
Background: Growing bodies of evidence suggest that angiogenesis plays a crucial role in the development and progression of multiple sclerosis (MS). Vascular endothelial growth factor (VEGF) is one of the key factors involved in angiogenesis. Because of this importance, we investigated the serum levels of VEGF in MS patients according to their clinical phase and subtype of MS in this study. Material
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Gabapentinoids Suppress Lipopolysaccharide-Induced Interleukin-6 Production in Primary Cell Cultures of the Rat Spinal Dorsal Horn Neuroimmunomodulation (IF 2.4) Pub Date : 2022-07-15 Franz Nürnberger, Christoph Rummel, Daniela Ott, Rüdiger Gerstberger, Martin J. Schmidt, Joachim Roth, Stephan Leisengang
Introduction: Gabapentin and pregabalin are drugs to treat neuropathic pain. Several studies highlighted effects on presynaptic terminals of nociceptors. Via binding to α2δ subunits of voltage-gated calcium channels, gabapentinoids modulate the synaptic transmission of nociceptive information. However, recent studies revealed further properties of these substances. Treatment with gabapentin or pregabalin
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Clinical Experience in the Diagnosis and Treatment of Adult Acute Necrotizing Encephalopathy Neuroimmunomodulation (IF 2.4) Pub Date : 2022-06-27 Mei-Ling Wang, Rui Liu, Li-Mei Zhang, Bin Zhao, Rui Jia, Yang Zhao, Ya-Lin Xi, Jing-Xia Ma, He Ma
Purpose: We report two cases diagnosed as acute necrotizing encephalopathy (ANE) with acute onset and various clinical manifestations. Methods: The patients’ data were obtained from the medical records of the Binzhou Medical University Hospital in Binzhou, China. The clinical symptoms, laboratory examination, neuroimaging, treatment, and prognosis of the 2 patients were collected and analyzed. Results:
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Irisin Protects Cerebral Neurons from Hypoxia/Reoxygenation via Suppression of Apoptosis and Expression of Pro-Inflammatory Cytokines Neuroimmunomodulation (IF 2.4) Pub Date : 2022-06-15 Qian Yu, Guangyao Li, Jiangjing Li, Li Sun, Yonghui Yang, Lei Tao
Background: Ischemic stroke is a major health issue that causes high incidents of morbidity and mortality worldwide. Irisin is an excise-induced protein that has exhibited pleiotropic properties. Accumulating evidence reveals its critical roles in the regulation of various cellular functions, including nervous system functions. This study aims to disclose the effect of irisin on rat cerebral neurons
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Role of Immune and Inflammatory Mechanisms in Stroke: A Review of Current Advances Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-31 Hui Zhao, Yan Li, Ying Zhang, Wen-Yan He, Wei-Na Jin
Stroke accounts for a large proportion of morbidity and mortality burden in China. Moreover, there is a high prevalence of the leading risk factors for stroke, including hypertension and smoking. Understanding the underlying mechanisms and developing effective therapeutic interventions for patients with stroke is a key imperative. The pathophysiology of stroke involves a complex interplay between the
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Analysis of Resting Energy Consumption and Its Influencing Factors in Stroke Patients with Severe Neurological Diseases: A Retrospective Clinical Study Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-25 Hui Feng, Huaping Pan, Wei Yao, Chengyao Mei
Background: This study aimed to observe the changes of resting energy metabolism in patients with severe neurological diseases, and to explore the effects of tracheostomy status, stroke severity, and complications on resting energy expenditure (REE) and respiratory quotient (RQ). Methods: A retrospective study was conducted in 105 patients with neurological rehabilitation who were hospitalized in the
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Silencing of TRIM44 Inhibits Inflammation and Alleviates Traumatic Brain Injury in Rats by Downregulating TLR4-NF-κB Signaling Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-24 Lin Zhu, Ce Dong, Xiongfei Yue, Pengzhen Ge, Guozhen Zheng, Zhanying Ye, Baogen Pan
Background: Neuroinflammation subsequent to traumatic brain injury (TBI) is important for the recovery of patients and is associated with neurodegenerative changes post-TBI. The tripartite motif containing 44 (TRIM44) protein is an E3 ligase involved in the regulation of immune function with no previously known link to TBI. This study explores the connection between TRIM44 and TBI. Methods: After induction
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Retraction Statement Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-23 Rainer H. Straub , Wilson Savino, John Blundell, Adriana Del Rey, Oscar A. Bottasso, J.M. Krueger, H. Ovadia, Keith W. Kelley, Rainer H. Straub, Agustín G. Zapata, James M. Krueger, Andrew N. Margioris, Haim Ovadia, Valeria Rettori, Bryan L. Spangelo, Errol B. De Souza, Esther M. Sternberg, Judith Szelenyi, Takeshi Tabira, Dennis D. Taub, Athanasios G. Tzioufas, João Palermo-Neto, Marta C. Romano,
Neuroimmunomodulation
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Pathophysiology and Clinical Management of Autoimmune Encephalitis-Associated Seizures Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-17 Shaofang Zhu, Jiabin Yu, Youliang Wu, Ju Peng, Xuemin Xie, Xiaojing Zhang, Haitao Xie, Lisen Sui
Seizures are a very common manifestation of autoimmune encephalitis (AE), ranging from 33% to 100% depending on the antigen, most often accompanied by other clinical features such as behavioral changes, movement disorders, memory deficits, autoimmune disturbances, and altered levels of consciousness. Unusual seizure frequency, resistance to antiepileptic treatment, and often, definitive response to
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Increased Concentrations of Circulating Interleukins following Non-Invasive Vagus Nerve Stimulation: Results from a Randomized, Sham-Controlled, Crossover Study in Healthy Subjects Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-16 Elisabeth Veiz, Susann-Kristin Kieslich, Dirk Czesnik, Christoph Herrmann-Lingen, Thomas Meyer, Julia Staab
Objective: The vagus nerve constitutes the main component of the parasympathetic nervous system and plays an important role in the regulation of neuro-immune responses. Invasive stimulation of the vagus nerve produces anti-inflammatory effects; however, data on humoral immune responses of transcutaneous vagus nerve stimulation (tVNS) are rare. Therefore, the present study investigated changes in serum
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Catalpol Alleviates Isoflurane-Induced Hippocampal Learning and Memory Dysfunction and Neuropathological Changes in Aged Mice Neuroimmunomodulation (IF 2.4) Pub Date : 2022-05-11 Weiqing Shi, Wenbing Zhang, Jinping Wang
Introduction: Isoflurane-associated perioperative neurocognitive disorders (PNDs) is a common complication that occurs commonly in elderly patients characterized by deterioration of hippocampus-dependent cognitive function. Mounting evidence has shown that hippocampal impairment and inflammatory processes are implicated in the pathogenesis of PNDs. Catalpol has been suggested to play a role in the
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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Presenting with Area Postrema Syndrome-Like Symptoms without Medulla Oblongata Lesions Neuroimmunomodulation (IF 2.4) Pub Date : 2022-04-14 Kosuke Iwami, Taichi Nomura, Sho Seo, Shingo Nojima, Kazufumi Tsuzaka, Akio Kimura, Takayoshi Shimohata, Ichiro Yabe
Introduction: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently described steroid-responsive meningoencephalomyelitis positive for cerebrospinal fluid (CSF) anti-GFAP antibody. Area postrema syndrome (APS) involves intractable hiccups, nausea, and vomiting, which is caused by medulla oblongata (MO) impairment. APS is a characteristic symptom of aquaporin-4 (AQP4) autoimmunity
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Analysis of the Mechanism of RAD18 in Glioma Neuroimmunomodulation (IF 2.4) Pub Date : 2022-04-01 Jiahua Sun, Jun Li, Zhengrong Lu, Lin Chen, Junfeng Ma
Introduction: This study aimed to evaluate the regulatory mechanism of RAD18 in glioma development. Methods: RAD18 expression was compared in glioma tumors and normal samples. Furthermore, we investigated the association between gene transcription and clinical factors in glioma samples, followed by functional enrichment analysis, screening for key Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways
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Construction and Validation of a Glioma Prognostic Model Based on Immune Microenvironment Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-30 Jian Zhou, Yuan Guo, Jianhui Fu, Qihan Chen
Objective: This study aims to construct a prognostic model based on the different immune infiltration statuses of the glioma samples. Methods: Glioma-associated dataset was assessed from The Cancer Genome Atlas database. Hierarchical cluster analysis was performed to classify the glioma samples. Single-sample gene set enrichment analysis was introduced to the glioma samples for immune infiltration
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Anti-IgLON5 Encephalopathy with Concomitant Herpes Virus Encephalitis Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-30 Yuge Wang, Rui Li, Xiaobo Sun, Jinchi Liao, Jianfang Li, Han Xia, Lisheng Peng, Wei Qiu, Yaqing Shu
Anti-IgLON5 encephalopathy is a new and rare autoimmune encephalitis with unclear pathophysiology. In this study, we reported an unusual case of anti-IgLON5 encephalopathy with concomitant herpes virus encephalitis. A 51-year-old man with HLA-DQB1*05:01 and HLA-DRB1*10:01, who suffered from an episode of acute encephalitis, mental disorders, and memory impairment was admitted to our hospital. Human
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14th Conference of the German Endocrine-Brain-Immune-Network (GEBIN) Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-28 Harald Engler
None Neuroimmunomodulation 2022;29:1–50
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Interleukin-10 Attenuates Behavioral, Immune and Neurotrophin Changes Induced by Chronic Central Administration of Interleukin-1β in Rats Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-22 Yong-Ping Zhang, Yu-Yu Li, Cai Zhang, Ya-Jun Li, Bai-Ping Liu, Yan Zhang, Ju-Da Lin, Cai Song
Background: Activated microglia can trigger pro-inflammatory cytokine releases and neuroinflammation, which may inhibit astrocytes to produce neurotrophins and anti-inflammatory factors. Both eventually lead to neuron apoptosis or death. Furthermore, effective antidepressant or anti-dementia treatments can reduce pro-inflammatory cytokines, while enhance interleukin (IL)-10 production. However, the
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Animal Model of Neonatal Immune Challenge by Lipopolysaccharide: A Study of Sex Influence in Behavioral and Immune/Neurotrophic Alterations in Juvenile Mice Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-10 Larissa Maria Frota Cristino, Adriano José Maia Chaves Filho, Charllyany Sabino Custódio, Silvânia Maria Mendes Vasconcelos, Francisca Cléa F. de Sousa, Lia Lira O. Sanders, David Freitas de Lucena, Danielle S. Macedo
Introduction: The prenatal/perinatal exposure to infections may trigger neurodevelopmental alterations that lead to neuropsychiatric disorders such as autism spectrum disorder (ASD). Previous evidence points to long-term behavioral consequences, such as autistic-like behaviors in rodents induced by lipopolysaccharide (LPS) pre- and postnatal (PN) exposure during critical neurodevelopmental periods
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Could SARS-CoV-2 Infection Be a Novel Risk Factor for Multiple Sclerosis? Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-02 Rehab Magdy, Mona Hussein
The outbreak of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has challenged the healthcare community worldwide. The SARS-CoV-2 primarily affects the respiratory system; however, strong evidence suggests that SARS-CoV-2 can be neuroinvasive, resulting in several neurological complications. It was previously assumed that some coronaviruses are involved in multiple sclerosis
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Retraction Statement Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-01 Rainer H. Straub , Wilson Savino, John Blundell, Adriana Del Rey, Oscar A. Bottasso, J.M. Krueger, H. Ovadia, Keith W. Kelley, Rainer H. Straub, Agustín G. Zapata, James M. Krueger, Andrew N. Margioris, Haim Ovadia, Valeria Rettori, Bryan L. Spangelo, Errol B. De Souza, Esther M. Sternberg, Judith Szelenyi, Takeshi Tabira, Dennis D. Taub, Athanasios G. Tzioufas, João Palermo-Neto, Marta C. Romano,
Neuroimmunomodulation
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Retraction Statement Neuroimmunomodulation (IF 2.4) Pub Date : 2022-03-01 Rainer H. Straub , Wilson Savino, John Blundell, Adriana Del Rey, Oscar A. Bottasso, J.M. Krueger, H. Ovadia, Keith W. Kelley, Rainer H. Straub, Agustín G. Zapata, James M. Krueger, Andrew N. Margioris, Haim Ovadia, Valeria Rettori, Bryan L. Spangelo, Errol B. De Souza, Esther M. Sternberg, Judith Szelenyi, Takeshi Tabira, Dennis D. Taub, Athanasios G. Tzioufas, João Palermo-Neto, Marta C. Romano,
Neuroimmunomodulation
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Neurofilament Light Chain Determination: Referee for Future Vitamin D3 Supplementation in Multiple Sclerosis? Neuroimmunomodulation (IF 2.4) Pub Date : 2022-02-09 Hans-Klaus Goischke
Neuroimmunomodulation