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Analysis of altered miRNA profiling in the colon of a mouse model with β-lactoglobulin allergy Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-10-29 Q.-m. Zhang; W.-w. Ni; Y. Li; X. Zhang; J.-c. Hou; X.c. Meng; A.-l. Li; Z.-m. Jiang
Objectives The differences in the expression profiles of colonic miRNAs between β-lactoglobulin (β-Lg) allergic mice and normal mice were analyzed to investigate the important role of the miRNA regulation mechanism in the pathogenesis of cow’s milk allergy. Methods The present study performed Illumina sequencing to characterize the miRNA profile changes in mouse colon responding to β-Lg challenge.
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Evaluation of patients with primary immunodeficiency associated with Bacille Calmette-Guerin (BCG)-vaccine-derived complications Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-10-25 M. Sohani; S. Habibi; S. Delavari; S. Shahkarami; Reza Yazdani; P. Shirmast; F. Nazari; T. Moeini Shad; S. Mamishi; G. Azizi; A.U. Anka; G. Hassanpour; A. Kalantari; M. Shariat; A. Shafiei; H. Abolhassani; A. Aghamohammadi
Background Bacille Calmette-Guerin (BCG) vaccination has a great impact on the prevention of severe complications of tuberculosis. However, in patients with primary immunodeficiencies (PID), it can lead to severe complications such as severe combined immunodeficiency, chronic granulomatous disease, and Mendelian susceptibility to mycobacterial disease. This study highlights the demographics, clinical
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Allergy to beta-lactam antibiotics in children: Looking for a practical approach. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-09-23 J A Porto
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Probiotics function and modulation of the immune system in allergic diseases. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-08-04 M Eslami,A Bahar,M Keikha,M Karbalaei,N M Kobyliak,B Yousefi
Allergic diseases have been a global problem over the past few decades. The effect of allergic diseases on healthcare systems and society is generally remarkable and is considered as one of the most common causes of chronic and hospitalized disease. The functional ability of probiotics to modulate the innate/acquired immune system leads to the initiation of mucosal/systemic immune responses. Gut microbiota
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Asthma control affects school absence, achievement and quality of school life: a multicenter study. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-08-04 M Toyran,I T Yagmur,H Guvenir,I A Haci,S Bahceci,S B Batmaz,O Y Topal,I K Celik,B Karaatmaca,E D Misirlioglu,E Civelek,D Can,C N Kocabas
Introduction and Objectives Asthma may have a detrimental effect on school attendance and achievement. Friend relations, attendance to school activities, quality of life (QOL) of asthmatic children may be negatively affected. The aim of this study was to evaluate factors influencing school functioning for asthmatic school-age children. Materials and Methods From January to May 2019, parents and school-age
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Adverse reactions and influencing factors in children with primary immunodeficiencies receiving intravenous immunglobulin replacement. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-21 I B P Ibis,B Erdur,S B Erdem,S Karaman,N Gulez,F Genel
Objectives We aimed to determine adverse reactions and influencing factors, within the scope of the number of patients and total infusions, in patients with primary immunodeficiencies receiving intravenous immunoglobulin (IVIG) replacement. Materials and methods Children with primary immunodeficiencies receiving IVIG replacement in Izmir Dr Behcet Uz Children’s Hospital, between June 2014 and June
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Effectiveness of allergy testing in milk induced eosinophilic esophagitis. Description and follow-up of patients. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-13 S Terrados,L Villafana,D Antolín-Amérigo,Cristina Camarero,J Martínez-Botas,L Sánchez-Ruano,B de la Hoz
Introduction Eosinophilic esophagitis (EoE) is a chronic, local immune-mediated esophageal disease that has been on the increase lately. There is currently enough evidence to conclude that EoE is an allergic disorder triggered by food allergens, with cow’s milk (CM) being the most frequent. Dietary intervention is the first-line approach. This study aimed to assess the clinical characteristics, the
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Serum sickness-like reactions in Iranian children: a registry-based study in a referral center. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-08 Azam Mohsenzadeh,Masoud Movahedi,Mohammad Saatchi,Nima Parvaneh,Mansoureh Shariat,Asghar Aghamohammadi,Mohammad Gharagozlou
Introduction and Objectives Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children’s Medical Center. Patients The present study was a registry-based study in which the data of 94 SSLRs
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Hymenoptera venom allergy among children in Italy: time for pediatricians to take action. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-08 M Giovannini,R Castagnoli,F Mori,S Arasi,S Barni,F Saretta,C Mastrorilli,L Pecoraro,L Liotti,L Caminiti,G L Marseglia,E Novembre,
Hymenoptera venom allergy (HVA) is one of the most frequent causes of anaphylaxis following a bee, vespid or ant sting. Real-life data regarding the management of HVA in children are lacking. To address this unmet need, we carried out a survey defining the current management of HVA in children among pediatric allergists in Italy. Educational investments on the improvement of the management of pediatric
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TREE NUTS ALLERGY: Knowledge, gaps and practical implications. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-04 Luis Á Echeverría-Zudaire
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SARS-CoV2 coronavirus: so far polite with children. Debatable immunological and non-immunological evidence. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-03 F Álvez
The reasons for the relative resistance of children to certain infections such as that caused by coronavirus SARS-CoV2 are not yet fully clear. Deciphering these differences can provide important information about the pathogenesis of the disease. Regarding the SARS-CoV2 virus, children are at the same risk of infection as the general population of all ages, with the most serious cases being found in
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BCG as a game-changer to prevent the infection and severity of COVID-19 pandemic? Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-03 A R Sharma,G Batra,M Kumar,A Mishra,R Singla,A Singh,R S Singh,B Medhi
The impact of COVID-19 is changing with country wise and depend on universal immunization policies. COVID-19 badly affects countries that did not have universal immunization policies or having them only for the selective population of countries (highly prominent population) like Italy, USA, UK, Netherland, etc. Universal immunization of BCG can provide great protection against the COVID-19 infection
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COVID-19 and air pollution: A dangerous association? Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-01 M Urrutia-Pereira,C A Mello-da-Silva,D Solé
In late 2019, a new infectious disease (COVID-19) was identified in Wuhan, China, which has now turned into a global pandemic. Countries around the world have implemented some type of blockade to lessen their infection and mitigate it. The blockade due to COVID-19 has drastic effects on the social and economic fronts. However, recent data released by the National Aeronautics and Space Administration
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Road toward rapid-molecular point of care test to detect novel SARS-coronavirus 2019 (COVID-19): Review from updated literature. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-07-01 S Ahmad,N Ali,M Kausar,H Misbah,A Wahid
Coronavirus disease 2019 (COVID-19) named by the WHO as a result of the global public health emergency. COVID-19 is caused by a new coronavirus named as novel coronavirus (2019-nCOV). From the first case reported in December 2019 it is now a pandemic situation and a major public health emergency. The COVID-19 transmission rate is very high, infecting two to three persons on average with contact to
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Atopy patch test in children with cow's milk and hen's egg allergy: Do clinical symptoms matter? Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-10 S Sirin Kose,S Asilsoy,D Tezcan,G Atakul,S Al,O Atay,O Kangalli Boyacioglu,N Uzuner,O Anal,O Karaman
Introduction and objectives Since early 2000s, atopy patch test (APT) has been used to determine non-IgE and mixed-type food allergies. Previous studies have reported conflicting results about the diagnostic value of APT in food allergies, due to non-standardized methods. We aimed to determine the diagnostic efficacy of APT compared to open oral food challenge (OFC) in patients diagnosed with cow's
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The status of FOXP3 gene methylation in pediatric systemic lupus erythematosus. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-29 S Hanaei,G Sanati,S Zoghi,S Gharibzadeh,V Ziaee,N Rezaei
Background Systemic lupus erythematosus (SLE) is an autoimmune disease caused by interaction of genetic, epigenetic, and environmental factors. One of the important epigenetic factors in SLE would be methylation of immune-related genes, such as FOXP3, which plays a role in activating the regulation and also the function of T cells. To date, the relationship between levels of serum bio-markers and the
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Improvement of the sensitivity of the detection of Gal d 6-specific IgE via biotinylation in vivo. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-06-10 L Huang,H Bao,S Li,J Zhang,L Li,B Zhang,Y Yu,Y Liu,H Li
Introduction and objectives This study aimed to compare the effects of different biotinylation methods on the performance characteristics of allergen-specific IgE detection. Materials and methods The Gal d 6 gene was cloned into the pAN6/pAC6 vector, resulting in rGal d 6-Bio/Bio-rGal d 6 vector. The fusion protein was expressed in Escherichia coli AVB101 and simultaneously biotinylated in a site-specific
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Role of nasal saline irrigation in the treatment of allergic rhinitis in children and adults: A systematic analysis. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-21 Y Wang,L Jin,S-X Liu,K Fan,M-L Qin,S-Q Yu
Background This meta-analysis aims to access the efficacy of nasal saline irrigation in the treatment of allergic rhinitis (AR) in adults and children. Methods Two authors independently searched databases up to December 2018. Differences in efficacy between saline irrigation and other treatments were compared. Subgroup analyses of discrepancy in effects between children and adults were performed. Results
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Omalizumab treatment in adolescents with chronic spontaneous urticaria: Efficacy and safety. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-25 M Kahveci,O Soyer,B Buyuktiryaki,B E Sekerel,U M Sahiner
Background Omalizumab is useful as an add-on treatment in patients unresponsive to high doses of second-generation antihistamines. This study aimed to evaluate the efficacy and safety of omalizumab treatment in adolescents with refractory chronic spontaneous urticaria (CSU). Methods CSU patients aged 12–18 years old with the diagnosis of symptomatic CSU and unresponsive to classical treatment were
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Anti-allergic function of α-Tocopherol is mediated by suppression of PI3K-PKB activity in mast cells in mouse model of allergic rhinitis. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-23 Geping Wu,Hongyan Zhu,Xinyang Wu,Lili Liu,Xingkai Ma,Yifang Yuan,Xingli Fu,Ling Zhang,Yan Lv,Di Li,Jianyong Liu,Jianbin Lu,Yan Yu,Menglin Li
Background Alpha-Tocopherol (α-TCP), one major form of vitamin E, has been known as a treatment for airway allergic inflammation. However, the role and mechanism of α-TCP in treating allergic rhinitis remains unclear. Objective In this study we examined the inhibitory function of α-TCP in a mouse model of allergic rhinitis. Methods Allergic phenotype was examined by hematoxylin and eosin staining.
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Minimal agreement between basophil activation test and immunoassay in diagnosis of penicillin allergy. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-06-09 B Leecyous,F Bakhtiar,M M Tang,Z H M Yadzir,N Abdullah
Introduction Basophil activation test (BAT) and immunoassays are the most widely used in vitro tests to diagnose IgE-mediated allergic reactions to penicillin. However, studies to determine if one test is interdependent from another are limited. Objective The present study aimed to measure the agreement between BAT and immunoassay in diagnosis of penicillin allergy. Method BAT was performed using penicillin
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Does delayed urticaria induced by drug allergy exist? Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-06-03 E Del Vescovo,M Gelsomino,G Bersani,S Miceli Sopo
With the help of a routine clinical case about delayed urticaria induced by drug, we have analyzed the scientific societies reports published during the last 5 years on this topic. We highlighted the differences between the EAACI consensus and documents on drug allergy, commenting their positions and some of their definitions on delayed urticaria. However, the question of disagreement between definitions
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The use of in vivo and in vitro tests in children with beta lactam allergy. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-27 O Akcal,S Ozen,I Taskirdi,I A Haci,E T Kanik,C S Karkiner,D Can
Background Drug allergies are reactions within the context of drug hypersensitivity reactions, which are caused by immunological mechanisms due to a previously sensitising drug. Beta-lactam antibiotics (BLA) are the leading agents causing drug hypersensitivity reactions in children. The aim of this study is to evaluate the diagnostic importance of in vivo and in vitro diagnostic tests in children with
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Venom allergy and knowledge about anaphylaxis among beekeepers and their families. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-24 Zeynep Hızlı Demirkale,E Yücel,Sevgi Sipahi Çimen,A Süleyman,C Özdemir,A Kara,Z Tamay
Background Beekeepers and their families are at an increased risk of life-threatening anaphylaxis due to recurrent bee-sting exposures. Objective The aim of this study is to evaluate the demographic features, previous history of anaphylaxis among beekeepers and their family members, and their knowledge about the symptoms and management of anaphylaxis. Methods A standardized questionnaire was administered
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Contact haptens in emollients marketed in two European countries (Poland and Spain). Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-24 K Kunkiel,M Sojewska,W Feleszko
Introduction and objectives Atopic dermatitis (AD) is the most common skin disease among pediatric patients, which affects up to 20% of children worldwide. Characterized by pruritus and eczema, it is also associated with improper skin barrier function and allergen sensitization. Here, we aimed to assess the presence of haptens in emollients marketed in two European countries: in Poland and Spain, as
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Allergy to beta-lactam antibiotics in children: Risk factors for a positive diagnostic work-up. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-24 E Dias de Castro,F Carolino,L Carneiro-Leão,J Barbosa,L Ribeiro,J R Cernadas
Background Allergy to beta-lactam (βL) antibiotics is highly reported in children, but rarely confirmed. Risk factors for a positive diagnostic work-up are scarce. The primary aim was to characterize the cases of children with confirmed βL allergy, investigating potential risk factors. Secondary aims were to assess the prevalence of allergy to βL in this population and to confirm the safety of less
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Seasonal allergic rhinitis and the role of apitherapy. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-22 Karsten Münstedt,Heidrun Männle
Background Apitherapy represents a certain form of complementary and alternative medicine that uses bee products in combination with other methods from this field. One of the basic concepts of this type of medicine is that all diseases can be treated using apitherapy. This study was performed to assess the recommendations from authors of books on apitherapy regarding the treatment of seasonal allergic
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Comparison of methemoglobin levels in food protein-induced enterocolitis syndrome and other gastrointestinal diseases in neonates. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-22 Eishi Makita,Sae Kuroda,Hiroaki Sato,Kae Itabashi,Atsuko Kawano,Misa Matsuura,Yohei Sugiyama,Daisuke Sugawara,Asami Maruyama,Ko Ichihashi
Introduction and objectives Methemoglobinemia has been reported to be associated with severe food protein-induced enterocolitis syndrome (FPIES). However, no reports have evaluated methemoglobin (MHb) levels in FPIES without symptomatic methemoglobinemia or the usefulness of MHb measurement for the diagnostic prediction of FPIES. To evaluate the MHb levels of patients with neonatal-onset FPIES and
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Antihistamines in children and adolescents: A practical update. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-21 G F Parisi,S Leonardi,G Ciprandi,A Corsico,A Licari,M Miraglia Del Giudice,D Peroni,C Salpietro,G L Marseglia
Histamine is a chemical mediator, released predominantly by tissue mast cells, circulating basophils, and neurons, which are activated in response to various immunological and non-immunological stimuli. Histamine has to bind to specific receptors to exert its physiological and pathophysiological functions. Endogenous histamine is the main mediator of the immediate allergic response, which moreover
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Lung disease in patients with common variable immunodeficiency. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-21 A L López,M V Paolini,D S Fernández Romero
Background Common Variable Immunodeficiency (CVID) is characterized by an impaired antibody production and a higher susceptibility to encapsulated bacterial infections. Lung disease is considered to be the most important cause of morbidity and mortality. Methods We analyzed clinical, radiological and functional characteristics in 80 patients with CVID assisted in the Unidad Inmunologia e Histocompatibilidad
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Immunogenicity of a new allergoid from Felis domesticus. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-20 J P Sola González,E Bravo Hernández,A Cerezo Abellán,M Peñalver-Mellado
Background The chemical modification of allergens with glutaraldehyde improves safety while maintaining clinical efficacy, which permits the administration of higher doses of immunotherapy, reducing the risk of adverse reactions. The aim of this study is to evaluate the immunogenic capacity of a new cat dander polymer by immunizing mice and quantifying immunoglobulin s in serum, in comparison with the
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Illness perceptions and quality of life in families with child with atopic dermatitis. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-20 V Siafaka,A Zioga,T Evrenoglou,D Mavridis,S Tsabouri
Objective To assess the Quality of Life (QoL) of children with Atopic Dermatitis (AD) and their families and the impact of the mothers’ illness perceptions on the family QoL. Materials and methods Seventy-five children with AD (54 infants and 21 children) and their mothers participated in the study. The following questionnaires were administrated: 1. Brief Illness Perception Questionnaire (Brief IPQ);
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Dust mite-derived Enterobacterial fimbriae H protein enforces the allergen specific immunotherapy in asthma mice. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-20 X Yang,H Wang,D Zhao,J Wang,X Liu,X Yuan,M Zhang,G Li,P Ran,P Yang,Z Liu
Background The mite alimentary canal contains plenty of microbiota. It is accepted that some of the microbial products function as adjuvants to speed up immune responses. Objectives We identified five bacterial proteins from dust mite, and Enterobacterial fimbriae H (FimH) was one of them. This study aims to test a hypothesis that the FimH protein enforces immunotherapy in asthmatic mice. Methods Asthmatic
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Autoimmune and inflammatory manifestations in pediatric patients with primary immunodeficiencies and their importance as a warning sign. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-20 M Yildirim Kaplan,S Ozen,O Akcal,N Gulez,F Genel
Introduction and objectives As well as increased susceptibility to infections, autoimmune and inflammatory manifestations also eventuate due to dysregulation of immune system in a substantial proportion of patients with primary immunodeficiency (PID). Autoimmune and inflammatory manifestations can occur prior or after diagnosis of PID. This study aimed to evaluate autoimmune and inflammatory complications
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Food allergen sensitization patterns in a large allergic population in Mexico. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-20 L T Ruiz Segura,E Figueroa Pérez,A Nowak-Wegrzyn,T Siepmann,D Larenas-Linnemann
Introduction and objectives Although food allergy is recognized as a growing worldwide public health problem, there continues to be limited data on prevalence rates in developing and emerging countries. Most prevalence estimates are based on self-reports, with only few studies using objective assessments. The aim was to analyze the frequency of sensitization to food allergens by serum specific IgE
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Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-18 K Tanaka,M Arakawa,Y Miyake
Background There is limited evidence on the association between prenatal smoking exposure and the risk of asthma in children. The aim of this prebirth cohort study was to investigate the association between prenatal and postnatal tobacco smoke exposure and the risk of asthma in Japanese children. Methods Study subjects were 1304 mother–child pairs. Information on the variables under study was obtained
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Prevalence of asthma, allergic rhinitis and pollinosis in a city of Brazil: A monitoring study. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-18 T B Oliveira,A L K Persigo,C C Ferrazza,E N N Ferreira,A B G Veiga
Background Allergic respiratory diseases such as asthma and allergic rhinitis have increased considerably in the last decades. Objective The present study estimates prevalence trends of asthma, allergic rhinitis and pollinosis in the population of a city of Southern Brazil, without restriction of age, from 2011 to 2018, using the ISAAC standardized questionnaire. Methods Data was collected from March
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Clinical and anatomopathological features of eosinophilic oesophagitis in children and adults. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-15 A Agulló-García,J L Cubero,A Lezaun,J Boné,I Guallar,C Colás
Introduction Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation. Objective To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital. Method Descriptive, retrospective and cross-sectional
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Tyrophagus putrescentiae group 4 allergen allergenicity and epitope prediction. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-14 F-X Teng,H-F Huang,D-Z Ge,L-L Yu,C Xu,Y-B Cui
Introduction and objectives Allergen-specific immunotherapy (ASIT) is the only allergic disease-modifying therapy available for children and adults, and recombinant allergens are an interesting approach to improve allergy diagnosis and ASIT. Tyrophagus putrescentiae is a common storage mite that produces potent allergens. The aim of this study was to express and characterize recombinant group 4 allergen
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Evaluation of the frequency and diagnostic delay of primary immunodeficiency disorders among suspected patients based on the 10 warning sign criteria: A cross-sectional study in Iran. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-11 A Bahrami,S Sayyahfar,Z Soltani,M Khodadost,B Moazzami,N Rezaei
Introduction The prevalence of undiagnosed primary immunodeficiency diseases is remarkably high and contributes to increasing the rate of morbidity and mortality among this group of patients. Objective To examine the 10 warning sign scoring system in patients suspected of primary immune deficiency and also estimate the diagnostic delay in patients with proven disease. Methods This descriptive cross-sectional
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Adverse reaction with hexavalent vaccine: An unusual case. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-10 M Tomás-Pérez,C Gómez-Traseira,M González-Muñoz,S Quirce
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Predictors of a positive oral food challenge to cow's milk in children sensitized to cow's milk. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-10 R Ayats-Vidal,L Valdesoiro-Navarrete,M García-González,O Asensio-De la Cruz,H Larramona-Carrera,M Bosque-García
Introduction and objectives The diagnosis of IgE-mediated cow's milk allergy (CMA) is often based on clinical history and on specific IgE levels and/or skin-prick tests (SPT), both of which are sensitive but not specific. The gold standard, oral food challenge (OFC), is expensive and time-consuming and involves a risk of severe allergic reactions. This study aimed to determine the value of specific
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Atopic dermatitis incidence and risk factors in young adults in Castellon (Spain): A prospective cohort study. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-10 A Arnedo-Pena,J Puig-Barberà,A Artero-Civera,M A Romeu-Garcia,N Meseguer-Ferrer,C Fenollosa-Amposta,A Vizcaino-Batllés,E Silvestre-Silvester,M R Pac-Sa,L Segura-Navas,M A Dubón,J Fabregat-Puerto,J B Bellido-Blasco
Introduction There are few atopic dermatitis (AD) incidence cohort studies in young adults, the etiology of this disease remains obscure, and AD risk factors in adults are not well understood. The objective of this study was to estimate AD ten-year incidence and prevalence in a cohort of adolescent aged 14–16 at inception in Castellon province in Valencia Region, Spain and describe related risk factors
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Factors associated with wheezing among Lebanese children: Results of a cross-sectional study. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-10 Diana Malaeb,Souheil Hallit,Hala Sacre,Rabih Hallit,Pascale Salameh
Background In Lebanon, asthma is underdiagnosed due to low access to healthcare, particularly in rural areas, although asthma diagnosis in children is based mainly on clinical symptoms. Thus, wheezing might be more suggestive of undiagnosed respiratory diseases including asthma in Lebanese children. This study aimed to determine the factors associated with wheezing in Lebanese children without asthma
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LTP allergy/sensitization in a pediatric population. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-10 A Aruanno,S Urbani,F Frati,E Nucera
Plant lipid transfer proteins (LTPs) are widespread plant food allergens, highly resistant to food processing and to the gastrointestinal environment, which have been described as the most common food allergens in the Mediterranean area. LTP allergy is widely described in adults, but it represents an emerging allergen also in the pediatric population. Little is known about the real prevalence and the
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Asthma diagnosis and lung testing: Where is the boundary of asthma? Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-07 Luis Moral
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Disagreement between guidelines regarding the third step of asthma drug therapy for school-age children. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-05-04 S Miceli Sopo,G Bersani,E Del Vescovo,M Gelsomino
With the help of a routine clinical case, we highlighted the difference between two of the best asthma guidelines available at the time regarding therapeutic suggestions for the so-called “third step” for school-age asthmatic children. We have analyzed the scientific evidence that each of the two guidelines brings to support their position. Finally, we have motivatedly solved the clinical scenario
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Network pharmacology-based study of the protective mechanism of conciliatory anti-allergic decoction on asthma. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-28 Xiaobo Xuan,Ziyan Sun,Chenhuan Yu,Jian Chen,Mei Chen,Qili Wang,Lan Li
Background This study aimed to explore the underlying anti-asthma pharmacological mechanisms of conciliatory anti-allergic decoction (CAD) with a network pharmacology approach. Methods Traditional Chinese medicine related databases were utilized to screen the active ingredients of CAD. Targets of CAD for asthma treatment were also identified based on related databases. The protein-protein interaction
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The MEFV gene and its association with familial Mediterranean fever, severe atopy, and recurrent respiratory tract infections. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-28 M H Celiksoy,C Dogan,B Erturk,E Keskin,B S Ada
Background Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease and is characterized by self-limiting episodes of fever and polyserositis. The aim of this study was to determine the atopic clinical findings associated with the MEFV gene. Methods A retrospective chart review was conducted of pediatric patients who had received a diagnosis of familial Mediterranean fever between
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Activated PI3K-delta syndrome in an Egyptian pediatric cohort with primary immune deficiency. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-27 Alshymaa A Ahmed,Alia A El Shahaway,Sameh A Hussien
Background Activated Phospho-Inositide 3 (PI3) Kinases Delta syndrome (APDS) can underlie primary immune deficiency. The prevalence and phenotypic characterization of these patients are not well described in Egypt. Objectives To describe patients with APDS in hospitalized children with recurrent respiratory tract infections with suspected primary immune deficiency. Methods 79 patients were included
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Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-21 Witchaya Srisuwatchari,Surapon Piboonpocanun,Unchalee Wangthan,Orathai Jirapongsananuruk,Nualanong Visitsunthorn,Punchama Pacharn
Introduction and Objectives Wheat and cereal grains have a broad range of cross-reactivity, but the clinical relevance of this cross-reactivity is uncertain. This study aimed to evaluate clinical and in vitro cross-reactivity with barley, oat, and Job’s tears among wheat-allergic patients. Materials and Methods Patients aged 5 to 15 years with IgE-mediated wheat allergy were enrolled. Skin prick test
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Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-17 E Keklikian,P Cornes,C J Cela,M Sanchez Solis,L García Marcos,J A Castro-Rodriguez
Introduction and objectives Wheezing (RW) infants with a positive asthma predictive index (API+) have a lower lung function as measured by forced expiratory techniques. Tidal flow-volume loops (TFVL) are easy to perform in infants, and sedation is not necessary. Materials and methods A total of 216 wheezing infants were successfully measured, and 183 of them were followed for over a year. TFVL loops
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Reference values of leukocyte and lymphocytes populations in umbilical cord and capillary blood in healthy Mexican newborns. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-04-17 S Scheffer-Mendoza,S E Espinosa-Padilla,G López-Herrera,F Mujica-Guzmán,M G López-Padilla,L Berrón-Ruiz
Introduction In newborns, dramatic changes occur in the blood and bone marrow during the first hours; there are rapid fluctuations in the quantities of leukocytes populations. In this work, we investigated leukocytes subsets counts in two types of blood samples (cord blood and capillary blood) extracted from healthy newborns. Methods Blood samples from Mexican neonates were collected by Instituto Nacional
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Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-02-13 Lígia Cristina Fonseca Lahoz Melli,Mírian Silva do Carmo-Rodrigues,Humberto Bezerra Araújo-Filho,Carolina Santos Mello,Soraia Tahan,Antônio Carlos Campos Pignatari,Dirceu Solé,Mauro Batista de Morais
BACKGROUND It is possible that imbalances in the composition of the gut microbiota or the relationship of the microbiota with the host may be implicated in the origin of allergy. Therefore, we studied the intestinal microbiota of children with atopic dermatitis (AD). METHODS Cross-sectional study with 81 children aged 5-11; 23 with AD and 58 controls. Surveys were conducted to obtain demographic, socioeconomic
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Exploratory study of language paediatricians use to promote adherence to long-term controller medication in children with asthma. Allergol. Immunopathol. (IF 1.276) Pub Date : 2020-02-25 Tom Koole,A Debbie C Jaarsm,Paul L P Brand
INTRODUCTION AND OBJECTIVES Although patient centred communication is associated with patients' daily medication adherence, the exact communication phenomena promoting high treatment adherence remain elusive. PATIENTS AND METHODS We used conversation analysis of videotaped follow-up consultations of seven outpatients (4-13 years of age) with chronic asthma and their caregivers, consulting two paediatric
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Assessment of regular drug use and inhaler technique skills in asthmatic children. Allergol. Immunopathol. (IF 1.276) Pub Date : 2019-10-16 Ceren Can,Emre Akkelle,Pınar Gökmirza Özdemir,Mehtap Yazıcıoğlu,Necdet Süt
OBJECTIVE This study aimed to assess the regular use of long-term asthma-control medication and to determine inhaler techniques in asthmatic children. METHODS The study was conducted on asthmatic children aged 6-18 years. Information on rescue and controller medications was given and the proper inhalation technique was demonstrated. One month later, patients and parents were asked to answer a questionnaire
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IL-33 is associated with allergy in children sensitized to the cat. Allergol. Immunopathol. (IF 1.276) Pub Date : 2019-08-30 K Smejda,A Borkowska,J Jerzynska,A Brzozowska,W Stelmach,I Stelmach
BACKGROUND Several studies suggest that early-life exposure to animal allergens constitutes a relevant risk factor for the development of allergic sensitization. OBJECTIVES The aim of the present study was to determine the role of interleukin-33 in children sensitive to cat allergen with allergic rhinitis and/or asthma. METHODS The study included 51 children aged 5-18 years, both sexes, allergic to
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Relationship between nasal mucociliary clearance and disease severity in children with allergic rhinitis: A comparative cross-sectional study. Allergol. Immunopathol. (IF 1.276) Pub Date : 2019-08-30 S B Batmaz,S Alicura Tokgöz
OBJECTIVES Mucociliary clearance (MCC) is impaired due to chronic inflammation in allergic rhinitis. Our aim was to evaluate MCC in children with allergic rhinitis, to determine its relationship with disease severity and evaluate MCC change after nasal irrigation. MATERIALS AND METHODS Saccharin test was performed in 51 patients with allergic rhinitis and in 50 controls. Nasal irrigation was performed
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Direct medical costs of pediatric asthma exacerbations requiring hospital attendance in a middle-income country. Allergol. Immunopathol. (IF 1.276) Pub Date : 2019-10-07 C E Rodriguez-Martinez,M P Sossa-Briceño,J A Castro-Rodriguez
INTRODUCTION AND OBJECTIVES With the aim of making informed decisions on resource allocation, there is a critical need for studies that provide accurate information on hospital costs for treating pediatric asthma exacerbations, mainly in middle-income countries (MICs). The aim of the present study was to evaluate the direct medical costs associated with pediatric asthma exacerbations requiring hospital
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Modulation effect of Lactobacillus acidophilus KLDS 1.0738 on gut microbiota and TLR4 expression in β-lactoglobulin-induced allergic mice model. Allergol. Immunopathol. (IF 1.276) Pub Date : 2019-08-30 W-W Ni,Q-M Zhang,X Zhang,Y Li,S-S Yu,H-Y Wu,Z Chen,A-L Li,P Du,C Li
OBJECTIVES β-lactoglobulin (β-Lg)-sensitized mice model was employed to investigate the correlation between Lactobacillus acidophilus KLDS 1.0738 (Lap KLDS 1.0738) modulating gut microbiota and inducting Toll-like receptors (TLRs) expression. METHODS The alterations of mice fecal microbiota were analyzed by 16S rRNA gene sequencing. The serum cytokines production and TLR4/NF-κB mRNA expression in the
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