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Early presentation of allergic contact dermatitis due to paraphenylenediamine Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-03 Irene Andrés Alberola, Eva Jiménez Hernández, José F. Soltero Carracedo, Alba Macías Panedas, Natalia Martín Iranzo, María Bartolomé Morate, Susana Alberola López, Jesús Rodríguez Calleja
Allergic contact dermatitis (ACD) is a more frequent pathology in adults than in children, because, in most cases, allergic sensitization requires a prolonged exposure time to the allergen, mostly months or years. In fact, the actual incidence and prevalence of ACD in children and adolescents is unknown. However, there is a hypothesis that ACD is increasing in the pediatric population. Among the allergens
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Mexican consensus on cow’s milk protein allergy Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Jaime Alfonso Ramírez Mayans, Karen Rubi Ignorosa Arellano, Erik Manuel Toro Monjaraz, Roberto Cervantes Bustamante, Marlene Alejandra Ruiz Castillo, Isabel de Jesús Medina Vera, Ana Gabriela Ayala Germán, Dante Vladimir Bacarreza Nogales, Lucía Casas Guzik, José Antonio Chávez Barrera, Sergio Díaz Madero, Laura Esther Flores Fong, Manuel Enrique Galaz Pantoja Méndez, Judith Ileana Gris Calvo, Rosa
Background: The aim of this study is to present the current views of a diverse group of experts on the diagnosis and treatment of Cow’s Milk Protein Allergy (CMPA) in children under 2 years of age in Mexico. Material and methods: The study, led by a scientific committee of five experts in CMPA, was divided into six phases, including a modified Delphi process. A total of 20 panelists, all of whom were
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Antioxidant defense of children and adolescents with atopic dermatitis: Association with disease severity Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Roseani Da Silva Andrade, Fabíola Isabel Suano de Souza, Carolina Sanchez Aranda, Marcia Carvalho Mallozi, Ariel Cordeiro Ferreira, Talita Lemos Neves Barreto, Fernando Luiz Affonso Fonseca, Roseli Oselka Saccardo Sarni, Dirceu Solé
Background: Atopic dermatitis (AD) is a relapsing, chronic cutaneous inflammatory disease with onset, in general, in early childhood. Chronic skin inflammation is associated with overproduction of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. Oxidative stress, an imbalance between the production of free radicals and antioxidant defense, results in tissue inflammation due to
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The frequency of sleep-disordered breathing in preschool children with asthma and its effects on control of asthma Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Murat Capanoglu, Tayfur Ginis, Betul Buyuktiryaki, Hakan Guvenir, Emine Vezir, Emine Dibek Misirlioglu, Muge Toyran, Refika Ersu, Can Naci Kocabas, Ersoy Civelek
Sleep-disordered breathing (SDB) is more common in asthmatic patients than in non-asthmatic persons, and SDB affects negatively to control asthma. A limited number of studies are discovered on the effect of SDB in preschool asthmatic children. In this study, we aimed to investigate the prevalence of SDB and its effect on control and severity of asthma in preschool children. A pediatric sleep questionnaire
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Toll-like receptors and Streptococcus mutans: An updated review article Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Fatima Zuhair Muhammad Al-Alawi, Ashraf Kariminik, Elaheh Tajbakhsh
It has been reported that toll-like receptors (TLRs) are the main innate immune receptors that recognize gram-positive pathogen-associated molecular patterns (PAMPs). The molecules can induce expression of the innate immune-related molecules that are essential against the bacteria. Streptococcus mutans (S. mutans) is a potential caries-associated pathogen, and innate immunity plays a key role in inhibiting
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Thymus vulgaris ameliorates cough in children with asthma exacerbation: a randomized, triple-blind, placebo-controlled clinical trial Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Elnaz Eskandarpour, Adel Ahadi, Arezoo Moini Jazani, Ramin Nasimi Doost Azgomi, Rasol Molatefi
Background: Asthma is one of the most common chronic respiratory diseases with inflammatory involvement and has a high burden worldwide. This study aimed to determine the effect of Thymus vulgaris (TV) on cough in children between 5 and 12 years old with mild to moderate asthma exacerbation. Methods: In this randomized, triple-blind clinical trial, 60 children between the ages of 5 and 12 with asthma
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Neurological involvement in patients with primary immunodeficiency Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Hulya Kose, Zuhal Karali, Muhittin Bodur, Sukru Cekic, Sara Sebnem Kilic
Introduction: Primary immunodeficiency diseases (PID) are defined by recurrent infections, allergies, autoimmunity, and malignancies. Neurologic symptoms are one of the major components of some immunodeficiency syndromes, such as Ataxia-Telangiectasia (AT), Nijmegen breakage syndrome (NBS), and Purine Nucleoside Phosphorylase (PNP) deficiency, which are considered as the primary involvement. Various
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Studies on the effect and mechanism of CD147 on melanoma stem cells Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Yuan Jiang, Renyi Liang, Liqun Li, Jian Guan
Background: Melanoma is the most aggressive form of skin cancer. Melanoma stem cells (MSCs) are one of the driving forces of melanoma invasion and metastasis. Therefore, it is of great significance to explore the mechanisms that maintain the stemness of MSCs. In this study, CD147-positive (CD147+) MSCs derived from A375 cell line were characterized. Methods: Side population (SP) and non-SP cells were
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Clinical outcome and component-specific antibody levels in egg allergic children after lightened oral immunotherapy Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Anna Koffert, Jussi Liippo, Eliisa Löyttyniemi, Johannes Savolainen
Objective: To evaluate the clinical outcome of lightened version of egg oral immunotherapy (OIT) and to analyze egg allergen component-specific antibody levels during short up-dosing with egg white powder and maintenance by egg in daily diet. Patients and methods: Eighteen egg-allergic children received egg powder with short up--dosing and they maintained tolerance using egg in daily diet. Seventeen
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Polyphyllin II inhibits NLPR3 inflammasome activation and inflammatory response of Mycobacterium tuberculosis–infected human bronchial epithelial cells Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Guodong Cheng, Gengzhi Ye, Ying Ma, Yuqing Wang
Background: The bronchial infection by Mycobacterium tuberculosis (Mtb) is increasing in prevalence and severity worldwide. Despite appropriate tuberculosis treatment, most patients still develop bronchial stenosis, which often leads to disability. Polyphyllin II (PP2) is a steroidal saponin extracted from Rhizoma Paridis. In this study, we aimed to explore the effect of PP2 on the advancement of Mtb-induced
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Snail-induced anaphylaxis in patients with underlying Artemisia vulgaris pollinosis: the role of carbohydrates Allergol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 Manuel Prados-Castaño, Stefan Cimbollek, Borja Bartolomé, Miriam Castillo, Joaquin Quiralte
Purpose: The importance of carbohydrates in anaphylaxis has been described with some foods. The current work intends to obtain clinical and immunological evidence of the importance of the O-glycans for IgE binding activity in anaphylactic reactions due to Helix aspersa (HA) ingestión and Artemisia vulgaris (AV) exposition. Methods: The studio focused on two cases of IgE-mediated anaphylaxis induced
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Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE? Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Sanem Eren Akarcan,Handan Duman Şenol,Figen Gülen,Esen Demir
Oral immunotherapy (OIT) has gained popularity recently for IgE-mediated food allergy. Omalizumab (OMZ) has been used in patients (10-20%) who have too severe/frequent allergic reactions (AR) to continue OIT, to reduce these reactions. In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment.
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Erythropoietin inhibits neutrophil extracellular traps formation to ameliorate lung injury in a pneumonia model. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Sheng Ye,Wei Li,Jinghui Yang,Xiang Xue,Jiao Chen,Wei Zhao,Lei Jiang,Ling Jia
BACKGROUND Severe pneumonia is a kind of disease that develops from lung inflammation, and new drugs are still required to treat the same. Erythropoietin (EPO) is widely used to treat anemia in patients. However, there are fewer studies on the role of EPO in neutrophil extracellular trappings (NETs) and pneumonia, and the mechanism is unclear. OBJECTIVE To investigate the possible effects of EPO on
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Clinical use of ketoprofen lysine salt: a reappraisal in adolescents with acute respiratory infections. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Gian Luigi Marseglia,Giorgio Ciprandi
Upper respiratory infections are widespread, and they are mainly of viral etiology. It has to be remarked that every infection is always associated with an inflammatory response. Inflammation implicates a cascade of bothersome symptoms, including fever, pain (headache, myalgia, and arthralgia), malaise, and respiratory complaints. As a result, anti-inflammatory medications could be beneficial as they
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Changes and clinical significance of serum MMP-9, TIMP-1, COX-2, and immune levels in patients with asthma. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Hong Ming,Youming Huang,Jinjuan Mao,Hui Wang,Xiufeng Gao,Zhidian Li
OBJECTIVE To detect serum metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases (TIMP-1), cyclooxygenase-2 (COX-2), and T helper cells 1-T helper cells 2 (Th1-Th2) levels in asthma patients and assess their clinical significance. METHODS A total of 72 patients experiencing acute asthma (acute group), 66 stable asthma patients (stable group), and 60 healthy volunteers (control group) were
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Asthma exacerbations in the pediatric emergency area: Evaluation and prospects for improvement of pre-hospital care. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Victor Gonzalez-Uribe,Elsy Maureen Navarrete-Rodríguez,Fernando Sebastián Angeles-Tellez,Jose Angel Montiel-Gonzalez,Jorge Colin-Rubio,Clara Fernanda Gonzalez-Chavarria,Zaira Selene Mojica-Gonzalez
INTRODUCTION The frequency of visits to emergency department for asthma is a significant public health problem in pediatrics. This study aimed to identify the characteristics of children who visited the pediatric emergency department for asthma exacerbation and evaluated their therapeutic management prior to admission. METHODS A prospective study was conducted over a 6-month period in the pediatric
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Corilagin attenuates airway inflammation and collagen deposition in ovalbumin-induced asthmatic mice. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Yan Jin,Chunhua Yi
OBJECTIVE To investigate the effects of corilagin on inflammation and collagen deposition in ovalbumin (OVA)-induced asthma mouse model and uncover the mechanism. METHODS We constructed a mouse model of OVA-induced asthma. Enzyme-linked-immunosorbent serologic assays were conducted to detect the effects of corilagin on cytokines and Immunoglobulin E (IgE) production. Hematoxylin and eosin staining
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Dihydrokaempferol attenuates LPS-induced inflammation and apoptosis in WI-38 cells. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Qiao Wang,Liwen Zhang,Ping Pang
BACKGROUND Globally, pneumonia has been associated as a primary cause of mortality in children aged less than 5 years. Dihydrokaempferol (DHK) has been proposed for being correlated with the process of various diseases. Nevertheless, whether DHK has a role in the progression of infantile pneumonia remains unclear. This study aimed at exploring whether DHK was involved in the progression of infantile
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Clinical manifestations and expression of CD18 to guide the diagnosis of leukocyte adhesion deficiency type 1: Mexico experience. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Elma Isela Fuentes-Lara,Gabriel Emmanuel Arce-Estrada,Abner Bojalil-Cabildo,Marco Antonio Yamazaki-Nakashimada,Sara Elva Espinosa-Padilla,Luisa Berenise Gamez-Gonzalez,Rosa María Nideshda Ramirez-Uribe,Omar Josue Saucedo-Ramirez,Laura Berron-Ruiz
BACKGROUND Leukocyte adhesion deficiency type 1 (LAD-1) is an inborn error of immunity characterized by a defect in leukocyte trafficking. METHODS Patients with clinical suspicion of LAD-1 were referred to our institution. Complete blood count and flow cytometric analysis, to identify the expression of CD18, CD11b, and the lymphocyte population phenotyping, were performed, and statistical analysis
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Coptisine attenuates sepsis lung injury by suppressing LPS-induced lung epithelial cell inflammation and apoptosis. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Junjun Huang,Ke Ren,Lili Huang
OBJECTIVE This study aimed to investigate the functioning and mechanism of coptisine in acute lung injury (ALI). METHODS Murine Lung Epithelial 12 (MLE-12) cells were stimulated with lipopolysaccharide (LPS) to construct an in vitro pulmonary injury model to study the functioning of coptisine in sepsis-induced ALI. The viability of MLE-12 cells was assessed by the cell counting kit-8 assay. The cytokine
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Risk of allergic rhinitis in patients with inflammatory bowel disease: A systematic review and meta-analysis. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Jie Liu,Lun Cai,Rongrong Yang,Liping Wei,Huazheng Luo,Xiongbin Gui
BACKGROUND Numerous parallels exist between inflammatory bowel disease (IBD) and allergic rhinitis (AR), which include risk factors (such as environmental and genetic factors), pathogenesis (immune disorders, epithelial cell barriers, etc.), and treatment (immunosuppressants and immunomodulators, such as cyclosporine and steroids). However, the risk of AR in IBD patients is unknown. OBJECTIVE In this
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Auraptene alleviates inflammatory injury and cell apoptosis in children with pneumonia in vitro. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Yuebin Wang,Shuzhen Yuan,Wei Tan,Yuanyu Zhou,Ruiyun Liao,Wei Su
OBJECTIVE The aim of the present study is to investigate the effects of auraptene on inflammation and apoptosis of pneumonia cell model and uncover the mechanism. METHODS WI-38 cells were treated with lipopolysaccharide (LPS) to construct a pneumonia model. Cell counting kit-8 assay, enzyme-linked-immunosorbent serologic assay, and quantitative polymerase chain reaction assay were conducted to confirm
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Benralizumab in severe eosinophilic asthma: A real-world, single-center, observational study from Mexico. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Miguel Reyes José Luis,López Estrada Erika Del Carmen,Arroyo Rojas Monserrat Arroyo,Salas Hernández Jorge,Castañeda Valdivia Mauricio,Escobar Preciado Monserrat,Cano Salas Maria Del Carmen
INTRODUCTION Urbanization has increased the prevalence of asthma in lower- and middle-income countries. Severe eosinophilic asthma (SEA), a subtype of asthma, can be refractory to standard therapy. Biologics such as benralizumab target interleukin-5 and have demonstrated effectiveness in managing SEA. There exists no real-world evidence on the effectiveness of benralizumab in Mexico. Therefore, this
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Kaempferitrin alleviates LPS-induced septic acute lung injury in mice through downregulating NF-κB pathway. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Xiaoli Zhu,Yongyue Pan,Xin Xu,Jing Xu
BACKGROUND Acute lung injury (ALI) causes severe and uncontrolled pulmonary inflammation and has high morbidity in dying patients. OBJECTIVE This study aimed to evaluate the potential function of Kaempferitrin (Kae) and uncover its mechanisms in ALI. MATERIAL AND METHODS We evaluated the role of Kae in ALI through the lipopolysaccharide (LPS)-induced histopathological changes, lung wet/dry (W/D) ratio
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Evaluation of Psychiatric Symptomatology, Quality of Life, and Caregiver Burden in Mothers and Children with Primary Immunodeficiency. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Nülüfer Kılıç,Şuheda Kaya,Gülay Taşçı,Filiz Özsoy,Mehmet Kılıç
BACKGROUND The present study aimed to evaluate the quality of life, depression, and anxiety scores of children with primary immunodeficiency (PID) and depression, anxiety scores, and the caregiving burden of their mothers. METHODS A total of 149 children aged 2-18 years and their mothers were included in the present study, along with 125 healthy children and their mothers as a control group. The Pediatric
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LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-11-01 Na Li,Yulei Liu
OBJECTIVE To investigate the possible role of La ribonucleoprotein 7 (LARP7) in psoriasis through a mouse model and uncover its underlying mechanism. METHODS The back skin of C57BL/6 mice was smeared with IMquimod (IMQ) cream for 7 days to induce psoriasis. Immunoblot kit was used to detect the deacetylase activity of SIRT1 (member of sirtuin family). Hematoxylin and eosin staining was used to assess
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Oral food challenge in children with contact urticaria in reaction to cow's milk. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Manuela Rodrigues Coimbra,Laura Maria Lacerda Araújo,Nelson Augusto Rosário Filho
OBJECTIVE To evaluate the relationship between the occurrence of contact urticaria in reaction to cow's milk in infants and the diagnosis of cow's milk allergy (CMA) established by supervised oral food challenge. METHODS In this cross-sectional study, we identified 184 children who had undergone 221 oral food challenge (OFC) at a CMA reference center between July 2015 and August 2019. Of these, 23
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Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs in adults: Beyond current classification. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Pamir Çerçi,Reşat Kendirlinan,Suna Büyüköztürk,Aslı Gelincik,Derya Ünal,Semra Demir,Ferda Öner Erkekol,Gül Karakaya,Adile Berna Dursun,Serhat Çelikel,Dane Ediger,Oznur Abadoglu,Sevim Bavbek
BACKGROUND Hypersensitivity reactions (HSRs) to nonsteroidal anti-inflammatory drugs (NSAIDs) are a significant clinical issue. Several classifications have been proposed to categorize these reactions, including the current European Academy of Allergy and Clinical Immunology/European Network for Drug Allergy (EAACI/ENDA) classification. This study aimed to evaluate the applicability of this classification
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Does the severity of atopic dermatitis change with allergic sensitization? Is it real or a myth? Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Serdar Al,Suna Asilsoy,Özge Atay,Özge Kangallı,Nevin Uzuner
OBJECTIVE Atopic dermatitis (AD) is a chronic inflammatory skin disease that can occur at any age. This study aimed to evaluate the impact of food allergy on disease severity as well as clinical/laboratory findings in children with AD. METHODS Clinical and laboratory data of AD patients evaluated for food allergy between January 2021 and December 2022 were examined retrospectively. RESULTS Of the 52
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Risk factors predisposing children to food allergies. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Ecem Firtin,Isılay Turan,Deniz Ozceker,Betul Buyuktiryaki,Gonca Hancioglu,Selami Ulas,Sezin Naiboglu,Ciğdem Aydogmus,Recep Sancak,Mehmet Halil Celiksoy
BACKGROUND Food allergies are the most common cause of anaphylaxis in children, and their incidence is increasing globally. The aim of this study was to determine the risk factors leading to food allergies in childhood. METHODS Children with food allergies and non-atopic healthy children were compared using a questionnaire that included prenatal, neonatal, and postnatal risk factors. RESULTS A total
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Quality of life in children with food allergies, psychiatric symptoms, and caregiving burden of their mothers. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Nülüfer Kılıç,Şuheda Kaya,Gülay Taşçı,Filiz Özsoy,Mehmet Kılıç
OBJECTIVE The present study aimed to evaluate the quality of life in children with food allergies, the accompanying depression and anxiety disorders, and caregiving burden of their mothers. MATERIAL AND METHODS A total of 168 children with food allergy visiting our clinic and their mothers were included in the study group. The control group included 152 children who visited the healthy child follow-up
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Exposure to farm environment and its correlations with total IgE, IL-13, and IL-33 serum levels in patients with atopy and asthma. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Paulina Dydak,Barbara Sozańska
BACKGROUND The aim of the study was to evaluate total immunoglobulin E (IgE), IL-13, and IL-33 serum level in people with bronchial asthma and atopy, and in healthy control group depending on their exposure to farm animals currently and in the first year of life. METHODS The study included 174 individuals living in rural areas and in a small town. Standardized questions from the International Study
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PSTPIP2 is associated with disease severity in patients with pressure ulcer sepsis and has anti-inflammatory effects. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Xiaoxia Wang,Youli Wang,Jianjun Luo,Lipeng Wang,Liye Guo,Xinxin Zhu
BACKGROUND One of the common adverse reactions in patients with pressure ulcers (PU) is sepsis, which is mainly related to microbial infections caused by pathogenic organisms. The activation of nuclear factor kappa-B (NF-κB) frequently occurs in conjunction with pathogenic microbial infections. Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is closely related to inflammatory disorders
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Time effect of dupilumab to treat severe uncontrolled asthma in adolescents: A pilot study. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Cristiana Indolfi,Giulio Dinardo,Angela Klain,Marcella Contieri,Giuseppina Rosaria Umano,Alberto Decimo,Giorgio Ciprandi,Michele Miraglia Del Giudice
BACKGROUND Dupilumab is a new biological drug approved for the treatment of type 2 inflammatory diseases, such as asthma. Dupilumab is a fully humanized monoclonal antibody that acts against both interleukin-4 and interleukin-13 receptors. This study evaluated the time--dependent effect of dupilumab on asthma exacerbations and quality of life in adolescents with uncontrolled severe asthma. MATERIALS
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An unusual case of acquired angioedema associated with monoclonal gammopathies of uncertain significance. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Yun Liu,Guofeng Fan,Fei He,Hanwen Tong,Chenxiao Jiang,Peng Xu,Jun Wang
Acquired angioedema (AAE) is a rare disease due to the C1 esterase inhibitor (C1-INH) deficiency. Clinically, its symptoms are similar to hereditary angioedema (HAE) with hereditary C1-INH deficiency. Both conditions have the potential to cause upper airway obstruction, which can be fatal in clinical practice and thus require intense attention. Here, we'd like to discuss the clinical presentation,
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Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Lijun Meng,Tijun Gu,Jinhai Wang,He Zhang,Chao Nan
OBJECTIVE To investigate the regulatory mechanism of pleckstrin homology-like domain, family A, member 1 (PHLDA1) in sepsis-induced acute lung injury (ALI). METHOD Mice model of sepsis were established by cecal ligation and puncture (CLP). The expression of PHLDA1 was reduced by injecting short hairpin RNA (shRNA)-PHLDA1 into the tail vein. The levels of PHLDA1, pro-inflammatory cytokines, such as
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Prevalence and time trends of symptoms of allergic rhinitis and rhinoconjunctivitis in Spanish children: Global Asthma Network (GAN) study. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-09-01 Alberto Bercedo-Sanz,Antonela Martínez-Torres,Angel López-Silvarrey Varela,Francisco Javier Pellegrini Belinchón,Ines Aguinaga-Ontoso,Carlos González Díaz,Luis García-Marcos,Grupo Gan Spain
INTRODUCTION The time trends of the prevalence of rhinitis, rhinoconjunctivitis and nasal allergy previously described in the ISAAC (International Study of Asthma and Allergies in Childhood) in 2002 are unknown; or if the geographical or age differences in Spain persist. OBJECTIVE To describe the prevalence of rhinitis, rhinoconjunctivitis and nasal allergy in different Spanish geographical areas and
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Inhibition of CREB promotes glucocorticoids action on airway inflammation in pediatric asthma by promoting ferroptosis of eosinophils. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Tong Yu,Yiping Yu,Yingyu Ma,Guoqing Chen
BACKGROUND Pediatric asthma is a common chronic disease of childhood with airway inflammation. Cyclic adenosine monophosphate response element binding protein (CREB) plays a significant role in the transcription of proinflammatory genes, but its role in pediatric asthma has remained unclear. Herein, we investigated the functions of CREB in pediatric asthma. METHODS Eosinophils were purified from the
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MG53 alleviates airway inflammatory responses by regulating nuclear factor-κB pathway in asthmatic mice. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Sijia Tan,Mengtian Li,Xiaoxi Song
BACKGROUND Asthma is a common lung disease with increasing incidence and prevalence globally, thereby imposing a substantial global health and economic burden. Recently, studies have shown that Mitsugumin 53 (MG53) exhibits multiple biological functions and plays a protective role in a variety of diseases. However, the role of MG53 in asthma remained unknown; hence, in the present study we aimed to
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Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Fangfang Chu,Lei Liang,Fuzhe Chen
BACKGROUND AND AIM Bronchial asthma is a prevalent type of respiratory disease that affects a large proportion of pediatric patients. The purpose of this study is to further investigate the clinical effects of budesonide combined with montelukast sodium in treating bronchial asthma. METHODS Eighty six children with bronchial asthma were equally divided into study and control groups via randomized double-blind
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Effects of omalizumab combined with budesonide formoterol on clinical efficacy, pulmonary function, immune function, and adverse reactions in children with moderate and severe allergic asthma. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Fuzhe Chen,Lei Liang,Fang Fang Chu,Changlong Lu,Chongyu Xu
OBJECTIVE To evaluate the clinical efficacy and safety of combining omalizumab with budesonide formoterol to treat children with moderate and severe allergic asthma, and investigate the effect of this combination therapy on pulmonary and immune functions. METHODS The data of 88 children with moderate and severe allergic asthma, who were admitted to our hospital between July 2021 and July 2022, were
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Frequency of allergic reactions in egg allergic patients after receiving the yellow fever vaccine. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Maria Beatriz García-Paba,Camila Aparicio,Mateo Rodríguez,Sergio Moreno,Elizabeth García
BACKGROUND Immunization with live attenuated viral yellow fever vaccine (YFV) grants effective immunity in most cases, and is recommended and prioritized for residents and travelers of endemic countries. YFV is seldom administered to egg-allergic patients (EAP) since it is cultivated in embryonated chicken eggs and may contain residual egg proteins, being a problem for egg-allergic residents and travelers
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Effects of training on teachers' food allergy and anaphylaxis management self-efficacy levels. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Atiye Yıldırım,Meryem Ozturk Haney
BACKGROUND Children are affected by food allergies more than adults, so teachers have the most significant responsibility for food allergy management in schools. OBJECTIVE To determine the effect of food allergies and anaphylaxis management training on Turkish teachers' self-efficacy. MATERIAL AND METHODS In this study, 90 teachers were selected using convenience sampling. Data were collected before
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IgG food hypersensitivity: A potential hidden precipitant for chronic spontaneous urticaria A case report. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Emad Abdulkader Koshak,Ali Fahad Atwah,Hanan Mohammed Yaqoob Ahmad
BACKGROUND While the link between foods and chronic spontaneous urticaria (CSU) is controversial, many immunological mechanisms have been proposed to establish a causal relationship. OBJECTIVE To explore the potential benefit of avoiding immunoglobulin G (IgG)-mediated food hypersensitivity as a triggering factor in a case with CSU. HISTORY The patient is a 50-year-old woman who complained of CSU for
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Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Jing Chen,Mengtian Zhao,Wei Fang,Chaojun Du
BACKGROUND Pneumonia is an acute respiratory infection with increasing global incidences. Children are more susceptible to pneumonia than adults, and its incidences grow extremely high during peak seasons. Thus, it is necessary to investigate the pathogenesis and molecular mechanism of childhood pneumonia. METHODS This study examined the role of tumor necrosis factor alpha-inducible protein 1 (TNFAIP1)
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Tamibarotene targets heparin-binding protein for attenuating lung injury in sepsis. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Chuanjie Xu,Jianping Li
BACKGROUND Excessively active pulmonary inflammation is a hallmark of sepsis-induced lung damage. A synthetic retinoid drug called tamibarotene reduces inflammation in a variety of conditions, including acute promyelocytic leukemia (APL), renal fibrosis, and neuroinflammation. Its effect on sepsis-related lung injury, however, has not been explained. PURPOSE The purpose of the study was to investigate
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Therapeutic action of Kushen recipe extractive and its inhibitory effect on eotaxin in mouse models with contact dermatitis. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Cheng Peng,Quangang Zhu,Jiyong Liu,Jishun Yang,Benming You,Hualin Zhang,Yu Zhu,Jinhong Hu
BACKGROUND Treatment of skin allergic diseases remains a challenging research topic. OBJECTIVE To investigate the effect of Kushen recipe extractive (KS) gel on contact dermatitis (CD) of mouse. METHODS Allergic contact dermatitis (ACD) model of mouse was established. Immunohistochemical method (ICH) and flow cytometry method (FCM) were used to detect CD4+ and CD8+ T lymphocytes and explore the regulation
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Effect of budesonide formoterol combined with tiotropium bromide on pulmonary function and inflammatory factors in patients with asthma-COPD overlap syndrome. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Ting Jiang,Pengfei Li,Yang Wang
OBJECTIVE To investigate the clinical efficacy of combining budesonide formoterol with tiotropium bromide for treating asthma-chronic obstructive pulmonary disease overlap syndrome (AOCS). METHODS The data of 104 patients with AOCS admitted to our hospital from December 2019 to December 2020 were assessed, randomly and divided into an experimental group (comprising 52 patients, receiving drug combination
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Rapid maxillary expansion and nasal patency in mouth breathing children with maxillary atresia due to or not due to allergic rhinitis. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Paulo de Tarso Almeida Carvalho,Mario Cappellette Junior,Gustavo Falbo Wandalsen,Dirceu Solé
AIM To evaluate the effects of rapid maxillary expansion (RME) on nasal patency in mouth breathing (MB) children with maxillary atresia due to or not due to allergic rhinitis (AR) associated with asthma. METHODS Fifty-three MB children/adolescents (aged 7-14 years) with mixed or permanent dentition and maxillary atresia participated, with or without unilateral or bilateral crossbite. They formed the
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CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Hai Lin,Jinrong Yi
BACKGROUND Asthma is a common illness with chronic airway inflammation. C1q/tumor necrosis factor (TNF)-related protein 3 (CTRP3) plays a vital role ininflammatory response, but its effect on asthma is imprecise. Herein, we analyzed the functions of CTRP3 in asthma. METHODS The BALB/c mice were randomized into four groups: control, ovalbumin (OVA), OVA+vector, and OVA+CTRP3. The asthmatic mice model
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Prevalence of atopic dermatitis in the adolescent population of Catalonia (Spain). Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Toni Mora,Irene Sánchez-Collado,Joaquim Mullol,Rosa Muñoz-Cano,Paula Ribó,Antonio Valero
BACKGROUND Studies on the prevalence of atopic dermatitis (AD) for the adolescent cohort in general-based large populations are scarce worldwide. We performed a retrospective population--based observational cohort study of 76,665 adolescent patients diagnosed with AD in Catalonia (Spain). We studied the prevalence of AD by age, gender, disease severity, comorbidities, serum total immunoglobulin E (tIgE)
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FoxO4 mediates macrophage M2 polarization by promoting LXA4R expression in an ovalbumin-induced allergic asthma model in mice. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Tong Yu,Yiping Yu,Yingyu Ma,Guoqing Chen
BACKGROUND Asthma imposes a heavy burden due to its high prevalence. Forkhead box O4 (FoxO4) proteins participate in the modulation of cell progression. However, the role and mechanism of FoxO4 in asthma remains uncharted. METHODS An allergic asthma model was constructed by the induction of ovalbumin and interleukin (IL)-4 in mice and monocyte/macrophage-like Raw264.7 cells, respectively. The role
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Factors associated with allergic rhinitis and combined allergic rhinitis and asthma syndrome (CARAS) in adults undergoing immunotherapy in a tropical country: Is ISAAC-III questionnaire useful in adult populations? Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Augusto Peñaranda,Lucía C Pérez-Herrera,Manuela Gantiva,Sergio Moreno-López,Julian Manrique,Daniel Peñaranda,Elizabeth García
BACKGROUND Allergic diseases affect about 10-30% of the population in low- or middle-income tropical countries. Few studies describe the factors associated with allergic diseases in adult patients undergoing immunotherapy in Latin American countries. OBJECTIVE This study aimed to determine the factors associated with allergic rhinitis (AR) and AR in comorbidity with asthma (CARAS) in adults treated
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Protective effects of aloin on asthmatic mice by activating Nrf2/HO-1 pathway and inhibiting TGF-β/Smad2/3 pathway. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Siyu Wu,Yan Xia,Chengcheng Yang,Mei Li
BACKGROUND Asthma is a severe chronic respiratory disease affecting all age groups with increasing prevalence. Anti-inflammatory strategies are promising options for the treatment of asthma. Although the inhibitory effect of aloin on inflammation has been demonstrated in various diseases, its effect on asthma remains unknown. METHODS A mice asthma model was established by treating with ovalbumin (OVA)
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Circulating Pentraxin-3 and its association with C-reactive protein levels and disease activity in patients with chronic spontaneous urticaria. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Şengül Beyaz,Serkan Belkaya,Nida Öztop
INTRODUCTION Pentraxin-3 (PTX3) is a soluble long pentraxin molecule that regulates inflammatory responses. This study aimed to determine the plasma levels of plasma PTX-3 as an inflammation marker in chronic spontaneous urticaria (CSU) and whether the PTX3 levels correlate with disease activity and other clinical parameters, including acute phase reactants and biomarkers. METHODS The study included
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Cardiac arrhythmia and immune response in COVID-19 patients. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Chunlian Wang,Wenqiang Hao
The coronavirus disease 2019 (COVID-19) pandemic has presented substantial challenges for providing health care due to the numerous complications on the respiratory and cardiovascular systems of people. Cardiac arrhythmia is one of the cardiac complications, and it was observed in COVID-19 patients. Moreover, arrhythmia and cardiac arrest are common in COVID-19 patients in the intensive care unit.
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A different starting line for allergic march: food protein-induced allergic proctocolitis. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Semiha Bahceci,Pınar Kuyum Töz,Figen Celebi Celik,Demet Can
OBJECTIVE The aim of this study is to investigate the long-term prognosis of food protein--induced allergic proctocolitis (FPIAP) patients, the risk of developing both allergic and gastrointestinal diseases, and to evaluate whether it leads to allergic march. METHODS A total of 149 children who were diagnosed with FPIAP and developed tolerance at least 5 years prior to the study and 41 children (with
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Echinacoside alleviates airway remodeling and inflammation in an ovalbumin-induced neonatal mouse model of asthma by modulating the SIRT1-NF-κB pathway. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Yunbo Pan,Yijun Liu
PURPOSE Echinacoside (ECH) has been reported to have anti-inflammatory and anti-immune effects, and may be effective for treating asthma. This study aimed to investigate the effect of ECH on asthma. METHODS A mouse model of asthma was established by ovalbumin (OVA) induction, and the effect of ECH on airway remodeling in mice was evaluated using the Periodic Acid-Schiff stain and enzyme-linked immunosorbent
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Rosavin inhibits neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury by regulating the MAPK pathway. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Tianwei Gao,Juan Li,Lei Shi,Bo Hu
BACKGROUND Sepsis is a systemic organ dysfunction caused by infection, and the most affected organ is the lungs. Rosavin, a traditional Tibetan medicine, exerts an impressive anti--inflammatory effect. However, its effects on sepsis-related lung damage have not been investigated. PURPOSE This study aimed to investigate the effects of Rosavin on cecal ligation and puncture (CLP)-induced lung injury
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RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo. Allergol. Immunopathol. (IF 1.8) Pub Date : 2023-07-01 Junxiang Liu,Xuri Wu,Haixia Qin,Ying Hu,Zhiyun Zhang,Yanmei Wang,Jinlan Li
BACKGROUND Type 1 diabetes is one of the chronic autoimmune diseases. Its features include the immune-triggered pancreatic beta-cells destruction. Ubiquitin ligases RNF20 and RNF40 have been discovered to participate into beta cells gene expression, insulin secretion, and expression of vitamin D receptors (VDRs). However, no reports about the role of RNF20/RNF40 in type 1 diabetes are known till now