-
Differential signaling patterns of stimulated bone marrow-derived dendritic cells under α1-antitrypsin-enriched conditions Cell. Immunol. (IF 4.078) Pub Date : 2021-01-01 Eyal Ozeri; Peleg Rider; Shoham Rigbi; Galit Shahaf; Iulia I. Nita; Israel Sekler; Eli C. Lewis; Ronen Schuster
Dendritic cells (DCs) mature upon an inflammatory trigger. However, an inflammatory trigger can lead to a semi-mature phenotype, allowing DCs to evoke tolerance and expedite the resolution of inflammation. This duality likely involves context-dependent modulation of inflammatory signaling. Human α1-antitrypsin (hAAT) promotes semimature DCs. We examined changes in a wide spectrum of signaling cascades
-
Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection Cell. Immunol. (IF 4.078) Pub Date : 2021-01-06 Junyan Wang; Chuncui Huang; Jinyu Zhou; Keli Zhao; Yan Li
Changes in immunoglobulin G (IgG) glycan structures are currently believed to closely related to the emergence of cancer. In this review, we summarize the current body of evidence suggesting that differences in serum IgG glycosylation patterns correspond to changes in multiple types of cancer. Modifications include IgG terminal N-link galactosylation, IgG core fucosylation, IgG terminal sialylation
-
Galectin-9 as a biomarker of disease severity Cell. Immunol. (IF 4.078) Pub Date : 2021-01-14 Preeti Moar; Ravi Tandon
-
IFN-γ+ CD4+T cell-driven prophylactic potential of recombinant LDBPK_252400 hypothetical protein of Leishmania donovani against visceral leishmaniasis Cell. Immunol. (IF 4.078) Pub Date : 2020-12-21 Sunita Yadav; Jay Prakash; Om Prakash Singh; Mallikarjuna Rao Gedda; Shashi Bhushan Chauhan; Shyam Sundar; Vikash Kumar Dubey
Visceral leishmaniasis (VL) is a potentially fatal parasitic disease causing high morbidity and mortality in developing countries. Vaccination is considered the most effective and powerful tool for blocking transmission and control of diseases. However, no vaccine is available so far in the market for humans. In the present study, we characterized the hypothetical protein LDBPK_252400 of Leishmania
-
Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases Cell. Immunol. (IF 4.078) Pub Date : 2020-12-31 Ziqi Yue; Luningxiao Nie; Peng Zhang; Qin Chen; Qingguo Lv; Qi Wang
-
Importance of myeloid derived suppressor cells in cancer from a biomarker perspective Cell. Immunol. (IF 4.078) Pub Date : 2020-12-31 Suresh Gopi Kalathil; Yasmin Thanavala
Myeloid derived suppressor cells (MDSC) are a heterogenous population of immature myeloid cells that accumulate in tumor bearing host and migrate to lymphoid organs and tumor tissues. This process is controlled by a set of defined pro-inflammatory cytokines and chemokines, which are upregulated in malignancies. MDSC have strong immunosuppressive potential and constitute a major component of the tumor
-
Sorted B cell transcriptomes point towards actively regulated B cell responses during ongoing chronic hepatitis B infections Cell. Immunol. (IF 4.078) Pub Date : 2021-01-09 Stijn Van Hees; Bart Cuypers; Stefan Bourgeois; Zwier M.A. Groothuismink; Pieter Meysman; Pieter Van der Vlies; Rob de Knegt; Luisa Vonghia; Peter Michielsen; Sven Francque; Kris Laukens; Andre Boonstra; Thomas Vanwolleghem
The natural course of chronic hepatitis B virus (HBV) infections follows distinct clinical disease phases, characterized by fluctuating levels of serum HBV DNA and ALT. The immune cells and their features that govern these clinical disease transitions remain unknown. In the current study, we performed RNA sequencing on purified B cells from blood (n=42) and liver (n=10) of healthy controls and chronic
-
Comparing thermal stress reduction strategies that influence MDSC accumulation in tumor bearing mice Cell. Immunol. (IF 4.078) Pub Date : 2021-01-09 Cameron MacDonald; Samuel Ministero; Manu Pandey; Denisha Robinson; Evan Forti Hong; Bonnie Hylander; Philip McCarthy; Christopher Gordon; Elizabeth Repasky; Hemn Mohammadpour
Myeloid derived suppressor cells (MDSCs) are a diverse collection of immune cells that suppress anti-tumor immune responses. Decreasing MDSCs accumulation in the tumor microenvironment could improve the anti-tumor immune response and improve immunotherapy. Here, we examine the impact of physiologically relevant thermal treatments on the accumulation of MDSCs in tumors in mice. We found that different
-
Activated mesangial cells acquire the function of antigen presentation Cell. Immunol. (IF 4.078) Pub Date : 2020-12-31 Yinghua Zhao; Qinggang Li; Qing Ouyang; Lingling Wu; Xiangmei Chen
Mesangial cells (MCs), as resident cells of the kidneys, play an important role in maintaining glomerular function. MCs are located between the capillary loops of the glomeruli and mainly support the capillary plexus, constrict blood vessels, extracellular matrix components, produce cytokines, and perform phagocytosis and clearance of macromolecular substances. When the glomerular environment changes
-
HDAC1 potentiates CD4+ T cell activation by inhibiting miR-124 and promoting IRF1 in systemic lupus erythematosus Cell. Immunol. (IF 4.078) Pub Date : 2021-01-08 Jie Chen; Lihui Peng; Zixia Zhao; Qiuyu Yang; Feng Yin; Mao Liu; Xiao Luo; Chengsong He; Yue He
Systemic lupus erythematosus (SLE) is an autoimmune disease leading to considerable morbidity worldwide, which can be developed from a breakdown in immunological tolerance, resulting in T cell hyperactivation. T cell hyperactivation has been implicated in the tissue damage associated with many diseases. Although many researchers have identified the involvement of T-cell receptor-associated signaling
-
Stem cell-like memory T cells: A perspective from the dark side Cell. Immunol. (IF 4.078) Pub Date : 2021-01-05 Shujun Gao; Xiuting Liang; Hui Wang; Boyang Bao; Keyu Zhang; Yanling Zhu; Qixiang Shao
Much attention has been paid to a newly discovered subset of memory T (TM) cells—stem cell-like memory T (TSCM) cells for their high self-renewal ability, multi-differentiation potential and long-term effector function in adoptive therapy against tumors. Despite their application in cancer therapy, an excess of TSCM cells also contributes to the persistence of autoimmune diseases for their immune memory
-
Usefulness of IL-21, IL-7, and IL-15 conditioned media for expansion of antigen-specific CD8+ T cells from healthy donor-PBMCs suitable for immunotherapy Cell. Immunol. (IF 4.078) Pub Date : 2020-12-14 Julián A. Chamucero-Millares; David A. Bernal-Estévez; Carlos A. Parra-López
Clonal anergy and depletion of antigen-specific CD8+ T cells are characteristics of immunosuppressed patients such as cancer and post-transplant patients. This has promoted translational research on the adoptive transfer of T cells to restore the antigen-specific cellular immunity in these patients. In the present work, we compared the capability of PBMCs and two types of mature monocyte-derived DCs
-
Type 1 helper T cells generate CXCL9/10-producing T-bet+ effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Cell. Immunol. (IF 4.078) Pub Date : 2020-12-30 Tsuyoshi Nakayama; Motoki Yoshimura; Kazuhiko Higashioka; Kohta Miyawaki; Yuri Ota; Masahiro Ayano; Yasutaka Kimoto; Hiroki Mitoma; Nobuyuki Ono; Yojiro Arinobu; Makoto Kikukawa; Hisakata Yamada; Koichi Akashi; Takahiko Horiuchi; Hiroaki Niiro
-
Potential therapeutic effect of low-dose paclitaxel in melanoma patients resistant to immune checkpoint blockade: A pilot study Cell. Immunol. (IF 4.078) Pub Date : 2020-12-28 Christoffer Gebhardt; Sonja C.S. Simon; Rebekka Weber; Mirko Gries; Dong Hun Mun; Raphael Reinhard; Tim Holland-Letz; Viktor Umansky; Jochen Utikal
The low dose application of chemotherapeutic agents such as paclitaxel was previously shown to initiate anti-tumor activity by neutralizing myeloid-derived suppressor cells (MDSCs) in melanoma mouse models. Here, we investigated immunomodulating effects of low-dose paclitaxel in 9 metastatic melanoma patients resistant to prior treatments. Three patients showed response to therapy (two partial responses
-
The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth Cell. Immunol. (IF 4.078) Pub Date : 2020-12-18 Pengxiang Yang; Xingjian Cao; Huilong Cai; Panfeng Feng; Xiang Chen; Yihua Zhu; Yue Yang; Weiwei An; Yumin Yang; Jing Jie
-
Developmental pathways of myeloid-derived suppressor cells in neoplasia Cell. Immunol. (IF 4.078) Pub Date : 2020-12-16 Scott I. Abrams
Immunotherapy has become a major weapon against the war on cancer. This has culminated from decades of seminal work that led to the discovery of innovative approaches to drive adaptive immunity. Notably, was the discovery of immune checkpoint inhibitory receptors on T cells, and the subsequent development of monoclonal antibodies that target those receptors, known as immune checkpoint inhibitors (ICIs)
-
Reactive Myelopoiesis and the Onset of Myeloid-Mediated Immune Suppression: Implications for Adoptive Cell Therapy Cell. Immunol. (IF 4.078) Pub Date : 2020-12-26 Patrick Innamarato; Shari Pilon-Thomas
Adoptive T cell therapy (ACT) in combination with lymphodepleting chemotherapy is an effective strategy to induce the eradication of cancer, providing long-term regressions in patients. However, only a minority of patients that receive ACT with tumor-specific T cells exhibit durable benefit. Thus, there is an urgent need to characterize mechanisms of resistance and define strategies to alleviate immunosuppression
-
Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses Cell. Immunol. (IF 4.078) Pub Date : 2020-12-24 Stefanie Dietz; Julian Schwarz; Jessica Rühle; Martin Schaller; Birgit Fehrenbacher; Alexander Marmé; Evi Schmid; Andreas Peter; Christian F. Poets; Christian Gille; Natascha Köstlin-Gille
Immunological pregnancy complications are a main challenge in reproductive medicine. Mechanisms regulating the adaptation of the maternal immune system to pregnancy are incompletely understood and therapeutic options limited. Myeloid derived suppressor cells (MDSC) are immune-modulatory cells expanding during healthy pregnancy and seem to play a crucial role for maternal-fetal tolerance. Recent studies
-
Deep sequencing reveals the skewed B-cell receptor repertoire in plaques and the association between pathogens and atherosclerosis Cell. Immunol. (IF 4.078) Pub Date : 2020-12-11 Shucui Zhang; Shigang Zhang; Zongwei Lin; Xinjie Zhang; Xinyao Dou; Xiaoming Zhou; Xiaowei Wang; Zhe Wang; Qunye Zhang
The immune/inflammatory responses regulated by B cells are the critical determinants of atherosclerosis. B-cell receptor (BCR) plays pivotal roles in regulating B cell function. However, the composition and molecular characteristics of the BCR repertoire in atherosclerotic patients have not been fully elucidated. Herein we analyzed BCR repertoire in circulation and plaques of atherosclerotic patients
-
Functional responses of resident human T cells in intact liver tissue Cell. Immunol. (IF 4.078) Pub Date : 2020-12-22 Nicole Hollingshead; Xia Wu; Heidi Kenerson; Antony Chen; Ian Strickland; Helen Horton; Raymond Yeung; Ian N. Crispe
-
Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients Cell. Immunol. (IF 4.078) Pub Date : 2020-12-16 Malgorzata Kloc; Rafik M. Ghobrial; Agnieszka Lipińska-Opałka; Agata Wawrzyniak; Robert Zdanowski; Boleslaw Kalicki; Jacek Z. Kubiak
Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory
-
MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment Cell. Immunol. (IF 4.078) Pub Date : 2020-12-14 T. William Mudd; Chunwan Lu; John D. Klement; Kebin Liu
The majority of human colorectal cancer remains resistant to immune checkpoint inhibitor (ICI) immunotherapy, but the underlying mechanism is incompletely understood. We report here that MS4A1, the gene encoding B cell surface marker CD20, is significantly downregulated in human colorectal carcinoma. Furthermore, MS4A1 expression level in colorectal carcinoma is positively correlated with patient survival
-
Molecular cargo in myeloid-derived suppressor cells and their exosomes Cell. Immunol. (IF 4.078) Pub Date : 2020-12-07 Catherine Fenselau; Suzanne Ostrand-Rosenberg
Collaborative research is reviewed in which mass spectrometry-based proteomics and next generation sequencing were used qualitatively and quantitatively to interrogate proteins and RNAs carried in intact myeloid-derived suppressor cells (MDSC) and exosomes shed in vitro by MDSC. In aggregate exosomes more than 4000 proteins were identified, including annexins and immunosuppressive mediators. Bioassays
-
Identification of H7N9 hemagglutinin novel protein epitopes that elicit strong antibody-dependent, cell-mediated cytotoxic activities with protection from influenza infection in mouse model Cell. Immunol. (IF 4.078) Pub Date : 2020-12-06 Peipei Zhu; Xianghua Yi; Long Zhang; Yuting Liu; Siqi Wang; Jun Gu; Xuyou Zhu; Xiaoting Yu
Background Antibody-dependent cell-mediated cytotoxicity (ADCC) is one of the mechanisms connecting humoral immunity and cellular immunity and has been well-demonstrated in recent studies. Neutralizing antibodies and antibodies can mediate ADCC effects and both build a strong defense against H7N9 influenza virus infection. In our previous study, we found that H7N9 patients’ plasma displayed low neutralizing
-
IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy Cell. Immunol. (IF 4.078) Pub Date : 2020-11-29 Rebekka Weber; Christopher Groth; Samantha Lasser; Ihor Arkhypov; Vera Petrova; Peter Altevogt; Jochen Utikal; Viktor Umansky
Myeloid-derived suppressor cells (MDSC) are generated during tumor progression and suppress the anti-tumor functions of T and natural killer (NK) cells. Their enrichment is associated with a bad prognosis and a worse outcome of immunotherapy in cancer patients. The cytokine interleukin (IL)-6 was found to be a crucial regulator of MDSC accumulation and activation as well as a factor, stimulating tumor
-
Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics Cell. Immunol. (IF 4.078) Pub Date : 2020-12-06 Mireya Becerra-Díaz; Andrew D. Lerner; Diana H. Yu; Jeffrey P. Thiboutot; Mark C. Liu; Lonny B. Yarmus; Sonali Bose; Nicola M. Heller
-
Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy Cell. Immunol. (IF 4.078) Pub Date : 2020-11-13 Haoting Hsu; Sarah Boudova; Godfrey Mvula; Titus H. Divala; David Rach; Randy G. Mungwira; Francesca Boldrin; Giulia Degiacomi; Riccardo Manganelli; Miriam K. Laufer; Cristiana Cairo
Human Vγ9Vδ2 T cells respond to several diverse pathogens by sensing microbial cholesterol intermediates. Unlike CD4 T cells, they are poised for rapid Th1-like responses even before birth, which allows them to play a key role in the first line of defense against pathogens in early life. However, their regulation and functional maturation during infancy (in particular the acquisition of cytotoxic potential)
-
Role of orally induced regulatory T cells in immunotherapy and tolerance Cell. Immunol. (IF 4.078) Pub Date : 2020-11-14 Thais B. Bertolini; Moanaro Biswas; Cox Terhorst; Henry Daniell; Roland W. Herzog; Annie R. Piñeros
-
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury Cell. Immunol. (IF 4.078) Pub Date : 2020-10-31 Xinhao Zhao; Le Yang; Na Chang; Lei Hou; Xuan Zhou; Chengbin Dong; Fuquan Liu; Lin Yang; Liying Li
Excessive neutrophils are recruited to damaged tissue and cause collateral injury under chronic inflammatory conditions. Sphingosine 1-phosphate (S1P) modulates kinds of physiological and pathological actions by inducing recruitment of various cell types through S1P receptors (S1PRs). This study aimed to detect the S1P/S1PRs-mediated effects on neutrophil recruitment during chronic liver inflammation
-
Roxithromycin inhibits compound 48/80-induced pseudo-allergy via the MrgprX2 pathway both in vitro and in vivo Cell. Immunol. (IF 4.078) Pub Date : 2020-10-17 Yongjing Zhang; Jue Wang; Shuai Ge; Yingnan Zeng; Nan Wang; Yuanyuan Wu
Roxithromycin (ROX) is a macrolide antibiotic with a variety of immunological effects. Mast cells (MCs) play a key role in host defense, mediating hypersensitivity and pseudo-allergic reactions. Mas-related G protein-coupled receptor X2 (MrgprX2) is the main receptor related to pseudo-allergy. In this study, we investigated the anti-pseudo-allergy effect of ROX and its underlying mechanism. The effects
-
Effects of omalizumab on basophils: Potential biomarkers in asthma and chronic spontaneous urticaria Cell. Immunol. (IF 4.078) Pub Date : 2020-09-12 Dimitri Poddighe; Luca Vangelista
Omalizumab is an anti-IgE humanized monoclonal antibody approved for the treatment of severe asthma and chronic spontaneous urticaria. Omalizumab binds free serum IgE and antagonizes its interaction with FcεRI, which is considered the main pharmacodynamic mechanism responsible for the clinical response to the treatment. The reduction of IgE serum concentration down-regulates the cellular expression
-
Building a CAR-Treg: Going from the basic to the luxury model Cell. Immunol. (IF 4.078) Pub Date : 2020-09-28 Isaac Rosado-Sánchez; Megan K. Levings
Regulatory T cells (Tregs) control immune homeostasis and prevent exacerbated immune responses, and can be used as cell therapy to dampen a variety of autoimmune or autoinflammatory responses. Treg therapy is significantly more effective if the cells are antigen-specific. One way to re-direct the specificity of Tregs is to engineer them to express a Chimeric Antigen Receptor (CAR). Proof-of-concept
-
Immunogenic properties of immunoglobulin superfamily members within complex biological networks Cell. Immunol. (IF 4.078) Pub Date : 2020-10-11 Josué Odales; Jesus Guzman Valle; Fernando Martínez-Cortés; Karen Manoutcharian
Antibodies, T cell receptors and major histocompatibility complex molecules are members of the immunoglobulin superfamily and have pivotal roles in the immune system. The fine interrelation between them regulates several immune functions. Here, we describe lesser-known functions ascribed to these molecules in generating and maintaining immune response. Particularly, we outline the contribution of antibody-
-
Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity? Cell. Immunol. (IF 4.078) Pub Date : 2020-10-13 Ibo Janssens; Nathalie Cools
In autoimmunity, the important and fragile balance between immunity and tolerance is disturbed, resulting in abnormal immune responses to the body’s own tissues and cells. CD4+CD25hiFoxP3+ regulatory T cells (Tregs) induce peripheral tolerance in vivo by means of direct cell–cell contact and release of soluble factors, or indirectly through antigen-presenting cells (APC), thereby controlling auto-reactive
-
Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19 Cell. Immunol. (IF 4.078) Pub Date : 2020-10-15 Rajesh Rajaiah; Kandahalli V. Abhilasha; Mysore A. Shekar; Stefanie N. Vogel; Bannikuppe S. Vishwanath
-
Development, phenotypes of immune cells in BTBR T+Itpr3tf/J mice Cell. Immunol. (IF 4.078) Pub Date : 2020-09-26 Mohammad Nizam Uddin; Yunyi Yao; Kevin Manley; David A. Lawrence
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by a lack of social interaction, decreased verbal and non-verbal communication skills, and stereotyped repetitive behavior. There is strong evidence that a dysregulated immune response may influence neurodevelopment and thus may have a role in the development of ASD. This study focuses on the characterization
-
DIM mitigates the development of experimental autoimmune encephalomyelitis by maintaining the stability and suppressive function of regulatory T cells Cell. Immunol. (IF 4.078) Pub Date : 2020-10-17 Sujuan Yang; Lixi Tan; Yingying Chen; Aiqun Liu; Mingfan Hong; Zhongxing Peng
Recent studies have revealed that indoles, dietary ligands of the aryl hydrocarbon receptor (AhR), have immunomodulatory characteristics of balancing the differentiation of regulatory T cells (Tregs) and Th17 cells in multiple autoimmune diseases. In this study, we aimed to investigate the potency of the indole, 3,3′-diindolylmethane (DIM), on the stability and suppressive function of Tregs in experimental
-
NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes Cell. Immunol. (IF 4.078) Pub Date : 2020-10-17 Kazunori Nakayama; Hideya Onishi; Akiko Fujimura; Akira Imaizumi; Makoto Kawamoto; Yasuhiro Oyama; Shu Ichimiya; Satoko Koga; Yuichi Fujimoto; Kinichi Nakashima; Masafumi Nakamura
We previously reported that protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is upregulated in activated lymphocytes, acts as an immune checkpoint. However, the mechanism by which PTPN3 expression is enhanced in activated lymphocytes is unknown. In this study, we analyzed the mechanism of PTPN3 expression in activated lymphocytes with a view for developing a novel immune checkpoint inhibitor
-
The impact of TLR7 agonist R848 treatment on mast cell phenotype and activity Cell. Immunol. (IF 4.078) Pub Date : 2020-10-28 Justyna Agier; Ewa Brzezińska-Błaszczyk; Piotr Witczak; Elżbieta Kozłowska; Paulina Żelechowska
Bearing in mind that mast cell contribution to viral clearance is still not fully understood, in this study, we evaluated the effect of Toll-like receptor (TLR)7 viral single-stranded ribonucleic acid (ssRNA) mimic ligand, namely resiquimod (R)848, on mast cell phenotype and activity. We demonstrated that rat peritoneal mast cells exhibit surface and intracellular expression of ssRNA-specific TLR7
-
Sex Differences in EAE Reveal Common and Distinct Cellular and Molecular Components Cell. Immunol. (IF 4.078) Pub Date : 2020-10-22 Jack Wiedrick; Roberto Meza-Romero; Grant Gerstner; Hilary Seifert; Priya Chaudhary; Ashley Headrick; Gail Kent; Ashley Maestas; Halina Offner; Arthur A Vandenbark
Experimental autoimmune encephalomyelitis (EAE) is commonly used as an animal model for evaluating clinical, histological and immunological processes potentially relevant to the human disease multiple sclerosis (MS), for which the mode of disease induction remains largely unknown. An important caveat for interpreting EAE processes in mice is the inflammatory effect of immunization with myelin peptides
-
Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2-based chimeric antigen receptor Cell. Immunol. (IF 4.078) Pub Date : 2020-09-30 Ilian A. Radichev; Jeongheon Yoon; David W. Scott; Kurt Griffin; Alexei Y. Savinov
Type 1 Diabetes (T1D) is an autoimmune disease marked by direct elimination of insulin-producing β cells by autoreactive T effectors. Recent T1D clinical trials utilizing autologous Tregs transfers to restore immune balance and improve disease has prompted us to design a novel Tregs-based antigen-specific T1D immunotherapy. We engineered a Chimeric Antigen Receptor (CAR) expressing a single-chain Fv
-
Conventional T cell therapies pave the way for novel Treg therapeutics Cell. Immunol. (IF 4.078) Pub Date : 2020-10-12 Lucy Z. Li; Zheng Zhang; Vijay G. Bhoj
Approaches to harness the immune system to alleviate disease have become remarkably sophisticated since the crude, yet impressively-effective, attempts using live bacteria in the late 1800s. Recent evidence that engineered T cell therapy can deliver durable results in patients with cancer has spurred frenzied development in the field of T cell therapy. The myriad approaches include an innumerable variety
-
Engineered regulatory T cells expressing myelin-specific chimeric antigen receptors suppress EAE progression Cell. Immunol. (IF 4.078) Pub Date : 2020-10-01 Alessandra De Paula Pohl; Anja Schmidt; Ai-Hong Zhang; Tania Maldonado; Christoph Königs; David W. Scott
The expansion of polyclonal T regulatory cells (Tregs) offers great promise for the treatment of immune-mediated diseases, such as multiple sclerosis (MS). However, polyclonal Tregs can be non-specifically immunosuppressive. Based on the advancements with chimeric antigen receptor (CAR) therapy in leukemia, we previously engineered Tregs to express a T-cell receptor (TCR) specific for a myelin basic
-
Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis Cell. Immunol. (IF 4.078) Pub Date : 2020-09-20 Carol Chase Huizar; Itay Raphael; Thomas G. Forsthuber
Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by autoimmune-mediated inflammatory lesions in CNS leading to myelin damage and axonal loss. MS is a heterogenous disease with variable and unpredictable disease course. Due to its complex nature, MS is difficult to diagnose and responses to specific treatments may vary between individuals. Therefore, there is an indisputable need
-
PHF14 is required for germinal center B cell development Cell. Immunol. (IF 4.078) Pub Date : 2020-09-28 Le Zhang; Yanlai Lu; Yuliang Wang; Feng Wang; Sulan Zhai; Zhengjun Chen; Zhenming Cai
Germinal centers (GCs), which are the site of antibody diversification and affinity maturation, are vitally important for humoral immunity. GC B cell proliferation is essentially for these processes by providing enough templates for somatic hypermutation (SHM) and serving as a critical mechanism of positive selection. In the current study, we found a significant reduction of GC response in the spleens
-
TNF contributes to T-cell exhaustion in chronic L. mexicana infections of mice through PD-L1 up-regulation Cell. Immunol. (IF 4.078) Pub Date : 2020-09-14 Eddie González-Tafoya; Mariana Diupotex; Jaime Zamora‐Chimal; Norma Salaiza‐Suazo; Adriana Ruiz‐Remigio; Ingeborg Becker
Leishmania mexicana can produce chronic infections leading to exhausted T cell phenotypes, mediated by PD-1/PD-L1. Little is known on mechanisms that induce these inhibitory molecules in chronic leishmaniasis. We analyzed factors that contribute to exhausted phenotypes in chronic L. mexicana infections of mice. Our results show that draining lymph node cells express enhanced levels of PD-1/PD-L1. T
-
CD4+ T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice Cell. Immunol. (IF 4.078) Pub Date : 2020-09-16 Richard Y. Fu; Alex C. Chen; Meghan J. Lyle; Chun-Yu Chen; Chao Lien Liu; Carol H. Miao
Although protein replacement therapy provides effective treatment for hemophilia A patients, about a third of severe patients develop neutralizing inhibitor antibodies to factor VIII. Adoptive transfer of regulatory T cells (Tregs) has shown promise in treating unwanted immune responses. In previous studies, transferred polyclonal Tregs ameliorated the anti-factor VIII immune responses in hemophilia
-
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence Cell. Immunol. (IF 4.078) Pub Date : 2020-09-05 Nianbin Song; Srona Sengupta; Stanislav Khoruzhenko; Robin A. Welsh; AeRyon Kim; Mithra R. Kumar; Søren Ulrik Sønder; John-William Sidhom; Hao Zhang; Chunfa Jie; Robert F. Siliciano; Scheherazade Sadegh-Nasseri
-
TLR engagement induces ARID3a in human blood hematopoietic progenitors and modulates IFNα production Cell. Immunol. (IF 4.078) Pub Date : 2020-09-09 Michelle L. Ratliff; Malini Shankar; Joel M. Guthridge; Judith A. James; Carol F. Webb
The DNA binding protein AT-rich interacting domain 3a (ARID3a)2 is expressed in healthy human hematopoietic cord blood progenitors where its modulation influences myeloid versus B lineage development. ARID3a is also variably expressed in subsets of adult peripheral blood hematopoietic progenitors where the consequences of ARID3a expression are unknown. In B lymphocytes, Toll-like receptor (TLR)3 signaling
-
Cellular uptake and anti-inflammatory effects of palm oil-derived delta (δ)-tocotrienol in microglia Cell. Immunol. (IF 4.078) Pub Date : 2020-08-28 Shi Wei Tan; Daud Ahmad bin Israf Ali; Huzwah Khaza'ai; Jia Woei Wong; Sharmili Vidyadaran
-
Human and murine memory γδ T cells: Evidence for acquired immune memory in bacterial and viral infections and autoimmunity Cell. Immunol. (IF 4.078) Pub Date : 2020-09-16 Kevin Comeau; Pierre Paradis; Ernesto L. Schiffrin
γδ T cells are unconventional lymphocytes that could play a role in bridging the innate and adaptive immune system. Upon initial exposure to an antigen, some activated T cells become memory T cells that could be reactivated upon secondary immune challenge. Recently, subsets of γδ T cells with a restricted antigen repertoire and long-term persistence have been observed after clearance of viral and bacterial
-
CD8+ T cells: The past and future of immune regulation Cell. Immunol. (IF 4.078) Pub Date : 2020-09-04 Jason R. Lees
Regulation of the adaptive immune response is critical for health. Regulatory activity can be found in multiple components of the immune system, however, the focus on particular components of the immune regulatory network has left many aspects of this critical immune component understudied. Here we review the evidence for activities of CD8+ T cells in immune homeostasis and regulation of autoimmune
-
Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use Cell. Immunol. (IF 4.078) Pub Date : 2020-09-09 Alaa Alzhrani; Matthew Bottomley; Kathryn Wood; Joanna Hester; Fadi Issa
Transplantation is limited by the need for life-long pharmacological immunosuppression, which carries significant morbidity and mortality. Regulatory T cell (Treg) therapy holds significant promise as a strategy to facilitate immunosuppression minimization. Polyclonal Treg therapy has been assessed in a number of Phase I/II clinical trials in both solid organ and hematopoietic transplantation. Attention
-
Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner Cell. Immunol. (IF 4.078) Pub Date : 2020-09-02 Irina G. Luzina; Rita Fishelevich; Brian S. Hampton; Jean-Paul Courneya; Francesca R. Parisella; Katerina N. Lugkey; Frank X. Baleno; Dohyun Choi; Pavel Kopach; Virginia Lockatell; Nevins W. Todd; Sergei P. Atamas
IL-33 has emerged as a central mediator of immune, inflammatory, and fibrotic responses. Many studies have focused on mature IL-33, but elevated expression of the precursor, full-length IL-33 (FLIL33), has also been implicated in a spectrum of diseases, including tissue fibrosis. We previously reported and now confirmed that overexpression of FLIL33 induced phosphorylation of the key profibrotic signaling
-
Schwann cells promote lung cancer proliferation by promoting the M2 polarization of macrophages Cell. Immunol. (IF 4.078) Pub Date : 2020-09-08 Yan Zhou; Jingwen Li; Baohui Han; Runbo Zhong; Hua Zhong
The interplay between immune cells and tumor cells determines the fate of tumorigenesis. Targeting the abnormal immune response of tumors has been recently achieved great success in some patients. Emerging evidence demonstrated the nervous system plays vital roles in immune regulation, but if the nervous system affects the immune-tumor response and the possible mechanism involved remain largely unexplored
-
Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor Cell. Immunol. (IF 4.078) Pub Date : 2020-09-11 Sigrid Dubois; Thomas A. Waldmann; Jürgen R. Müller
The development of T cell lymphomas in mice that constitutively express a single T cell receptor is surveilled by the action of NK cells. We investigated the effects of engaging the lymphoma TCR in this mouse model. We stimulated lymphoma cells expressing an ovalbumin-specific TCR in vivo using listeria monocytogenes as a vehicle. Infections with listeria expressing ovalbumin but not with control bacteria
-
Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon. Cell. Immunol. (IF 4.078) Pub Date : 2020-08-28 Helen J von Richthofen,Doron Gollnast,Toni M M van Capel,Barbara Giovannone,Geertje H A Westerlaken,Lisanne Lutter,Bas Oldenburg,DirkJan Hijnen,Michiel van der Vlist,Esther C de Jong,Linde Meyaard
Signal Inhibitory Receptor on Leukocytes-1 (SIRL-1) is expressed on human blood monocytes and granulocytes and inhibits myeloid effector functions. On monocytes, but not granulocytes, SIRL-1 expression is low or absent in individuals with the single nucleotide polymorphism (SNP) rs612529C. The expression of SIRL-1 in tissue and the influence of rs612529 hereon is currently unknown. Here, we used flow
-
Interferon-gamma increases monocyte PD-L1 but does not diminish T-cell activation. Cell. Immunol. (IF 4.078) Pub Date : 2020-08-21 Norman J Galbraith,Samuel P Walker,Sarah A Gardner,Campbell Bishop,Susan Galandiuk,Hiram C Polk
Immune dysfunction can occur during sepsis or following major trauma. Decreased monocyte HLA-DR expression and cytokine responses are associated with mortality. Recent studies have shown that adaptive immune system defects can also occur in such patients, characterised by increased PD-L1 expression and associated T-cell anergy. The aim of this study was to determine the effects of an immune adjuvant
-
Deciphering the role of calcium homeostasis in T cells functions during mycobacterial infection. Cell. Immunol. (IF 4.078) Pub Date : 2020-08-21 Aayushi Singh,Vandana Anang,Ankush Kumar Rana,Chaitenya Verma,Shakuntala Surender Kumar Saraswati,Priyanka Kumari,Aarti Singh,Krishnamurthy Natarajan
Calcium plays an important role in regulating cell physiology and immune responses to various pathogens. Our recent work has highlighted the crucial role for calcium homeostasis in dendritic cells and macrophages during various infections. Here we investigated the effect of calcium homeostasis in regulating T cell activation and function during mycobacterial infection. Results show that calcium homeostasis
-
The hepatic microenvironment and regulatory T cells. Cell. Immunol. (IF 4.078) Pub Date : 2020-08-14 Daniel Osei-Bordom,Amber G Bozward,Ye Htun Oo
The human liver is regarded as a lymphoid organ that contributes to both local and systemic immune response. Intrahepatic immune cells including regulatory T cells (Tregs) reside in the hepatic microenvironment which is enriched with proinflammatory cytokines, chemokines and metabolites. In addition, the hepatic microenvironment has the unique ability to establish and maintain immune tolerance despite
Contents have been reproduced by permission of the publishers.