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Electroencephalogram-detected stress levels in the frontal lobe region of patients with dry eye Ocul. Surf. (IF 6.4) Pub Date : 2024-03-07 Minako Kaido, Reiko Arita, Yasue Mitsukura, Kazuo Tsubota
To evaluate stress levels extracted from prefrontal electroencephalogram (EEG) signals and investigate their relationship with dry eye symptoms. This prospective, cross-sectional, comparative study included 25 eyes of 25 patients with aqueous tear-deficient dry eye (low Schirmer group), 25 eyes of 25 patients with short tear breakup time dry eye (short breakup time group), and 24 eyes of 24 individuals
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Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia Ocul. Surf. (IF 6.4) Pub Date : 2024-03-01 Sofia De Arrigunaga, Sarah Wall, Despoina Theotoka, Asaf Friehmann, Matthew Camacho, Sander Dubovy, Anat Galor, Carol L. Karp
Chronic inflammation is a predisposing factor for metaplastic changes and ultimately dysplasia. We describe cases of OSSN occurring in the setting of chronic ocular surface inflammation. Sixteen eyes from 14 individuals were included from one ocular oncology clinic between 2010 and 2023. Patients presented with ocular surface squamous neoplasia (OSSN) in the setting of chronic inflammation. The diagnosis
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Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors Ocul. Surf. (IF 6.4) Pub Date : 2024-02-22 Michael E. Stern, Argyrios N. Theofilopoulos, Philipp Steven, Jerry Y. Niederkorn, Robert Fox, Margarita Calonge, Christof Scheid, Stephen C. Pflugfelder
The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, systemic sclerosis and lupus. As the most environmentally exposed mucosal surface of the body, the conjunctiva constantly responds to environmental challenges which
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Heritability of tear fluid cytokines in healthy twins Ocul. Surf. (IF 6.4) Pub Date : 2024-02-20 Jakob Bjerager, Morten Magnø, Xiangjun Chen, Mohamed Belmouhand, Hans Christian D. Aass, Sjur Reppe, Steffen Heegaard, Michael Larsen, Tor P. Utheim
Ocular surface disease is common and it is associated with elevated concentration levels of cytokines in tear fluid. Studies of the normal variation in tear fluid inflammatory markers are lacking. New knowledge may help guide research into ocular surface disease biomarkers and therapeutics. In this prospective twin cohort study, healthy individuals were recruited from a population-based registry. Tear
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Pipeline: Ocular biostatistics: Proper use of proportions Ocul. Surf. (IF 6.4) Pub Date : 2024-02-20 Gary D. Novack
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Culture- and non-culture-based approaches reveal unique features of the ocular microbiome in dry eye patients Ocul. Surf. (IF 6.4) Pub Date : 2024-02-12 Maria Naqvi, Fredrik Fineide, Tor Paaske Utheim, Colin Charnock
The purpose of this study was to investigate the ocular microbiome in individuals with dry eye disease and to identify features of their ocular microbiome of possible health and diagnostic significance. Conjunctival samples were collected from both eyes in duplicate from 91 individuals (61 dry eye, 30 healthy) and used for both culture-dependent and culture-independent analyses. Samples were either
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Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study Ocul. Surf. (IF 6.4) Pub Date : 2024-02-02 Michelle Guo, Gabriela M. Diaz, Yinxi Yu, Chandani A. Patel, John T. Farrar, Penny A. Asbell, Gui-Shuang Ying
Some systemic medications are reported to be associated with dry eye disease (DED), yet their associations with the severity of DED signs and symptoms are not well studied. To evaluate these associations, we performed a secondary analysis of data from the DRy Eye Assessment and Management (DREAM) Study. Participants (N = 535) were assessed for DED signs using tear break-up time (TBUT), Schirmer testing
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The epidemiology of pediatric dry eye disease in the United States: An IRIS® registry (Intelligent Research in Sight) analysis Ocul. Surf. (IF 6.4) Pub Date : 2024-01-28 Vivian Paraskevi Douglas, Nathan Hall, Connor Ross, Konstantinos A.A. Douglas, Tobias Elze, Joan W. Miller, Alice C. Lorch, Aisha S. Traish
Purpose Dry-eye disease (DED) is a chronic progressive ocular surface disorder with limited studies in the pediatric population. The Academy of Ophthalmology's IRIS® Registry was leveraged to investigate the prevalence of DED in the pediatric population (PDED, patients <18 years old) and the demographic differences of DED between pediatric and adult patients (ADED). Methods Retrospective cohort study
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Corrigendum to “Topical formulations of aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration” [Ocul Surf 30 (2023) 92–103] Ocul. Surf. (IF 6.4) Pub Date : 2024-01-28 Filippo Bonelli, Ibrahim Demirsoy, Romina Mayra Lasagni Vitar, Philippe Fonteyne, Giulio Ferrari
Abstract not available
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Single-cell RNA sequencing reveals the complex cellular niche of pterygium Ocul. Surf. (IF 6.4) Pub Date : 2024-01-28 Xueling Zhang, Peizhen Han, Jini Qiu, Feifei Huang, Qiting Luo, Jingyi Cheng, Kun Shan, Yujing Yang, Chaoran Zhang
Purpose Pterygium is a vision-threatening conjunctival fibrovascular degenerated disease with a high global prevalence up to 12 %, while no absolute pharmacotherapy has been applied in clinics. In virtue of single-cell RNA sequencing (scRNA-seq) technique, our study investigated underlying pathogeneses and potential therapeutic targets of pterygium from the cellular transcriptional level. Methods A
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Corrigendum to “TFOS lifestyle: Impact of lifestyle challenges on the ocular surface” [Ocul Surf 28 (2023) 262–303] Ocul. Surf. (IF 6.4) Pub Date : 2024-01-25 Anat Galor, Alexis Ceecee Britten-Jones, Yun Feng, Giulio Ferrari, David Goldblum, Preeya K. Gupta, Jesus Merayo-Lloves, Kyung-Sun Na, Shehzad A. Naroo, Kelly K. Nichols, Eduardo M. Rocha, Louis Tong, Michael T.M. Wang, Jennifer P. Craig
Abstract not available
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Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43 Ocul. Surf. (IF 6.4) Pub Date : 2024-01-14 Jun Wu, Nu Chen, Elizabeth Grau, Luke Johnson, Yongqing Liu, Chi Li, Patrick A. Scott, Chang Kim, Deming Sun, Henry J. Kaplan, Hui Shao
Purpose Short chain fatty acids (SCFAs) produced by gut microbiota are known to play primary roles in gut homeostasis by immunomodulation partially through G-protein coupled receptors (GPR) 43. Using mouse models of TLR ligand induced keratitis, we investigated whether SCFAs and GPR43 play any regulatory roles in the pathogenesis of inflammatory responses in the eye. Methods Both human and mouse eyes
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Readership awareness series – Paper 9: Retraction of a publication Ocul. Surf. (IF 6.4) Pub Date : 2024-01-17 Mohammad Javed Ali, Ali Djalilian
Abstract not available
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Corneal acetylcholine regulates sensory nerve activity via nicotinic receptors Ocul. Surf. (IF 6.4) Pub Date : 2024-01-17 Takayoshi Masuoka, Takeshi Kiyoi, Shijie Zheng, Qiang He, Li Liu, Junsuke Uwada, Ikunobu Muramatsu
Purpose Sensory nerve terminals are highly distributed in the cornea, and regulate ocular surface sensation and homeostasis in response to various endogenous and exogenous stimuli. However, little is known about mediators regulating the physiological and pathophysiological activities of corneal sensory nerves. The aim of this study was to investigate the presence of cholinergic regulation in sensory
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Readership awareness series – Paper 8: Research ethics and ‘editorial expressions of concern’ Ocul. Surf. (IF 6.4) Pub Date : 2024-01-17 Mohammad Javed Ali, Ali Djalilian
Abstract not available
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The Yin and Yang of non-immune and immune responses in meibomian gland dysfunction Ocul. Surf. (IF 6.4) Pub Date : 2024-01-14 Cole J. Beatty, Raul E. Ruiz-Lozano, Manuel E. Quiroga-Garza, Victor L. Perez, James V. Jester, Daniel R. Saban
Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease and one of the most common ophthalmic conditions encountered in eye clinics worldwide. These holocrine glands are situated in the eyelid, where they produce specialized lipids, or meibum, needed to lubricate the eye surface and slow tear film evaporation – functions which are critical to preserving high-resolution vision. MGD results
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Comparative analysis of long-term results of three epithelial cell transplantation procedures for treating limbal stem cell deficiency Ocul. Surf. (IF 6.4) Pub Date : 2024-01-13 Sathiya Kengpunpanich, Chareenun Chirapapaisan, Panotsom Ngowyutagon, Suksri Chotikavanich, Rosanun Sikarinkul, Nuttacha Taetrongchit, Simaporn Setthawong, Pinnita Prabhasawat
This study compared the long-term outcome of different epithelial transplantation techniques to treat limbal stem cell deficiency (LSCD). We conducted a retrospective 15-year comparative systematic cohort study of patients with LSCD who underwent either cultivated limbal epithelial transplantation (CLET), simple limbal epithelial transplantation (SLET), or cultivated oral mucosal epithelial transplantation
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Self-complementary AAV vector therapy for treating corneal cloudiness of mucopolysaccharidosis type VII (MPS VII) Ocul. Surf. (IF 6.4) Pub Date : 2024-01-12 Jhuwala Venkatakrishnan, Yong Yuan, Jianhua Zhang, Yang Yu, Yueh-Chiang Hu, Winston W-Y Kao
Purpose To design a novel efficacious scAAV-Gusb viral vector for treating Mucopolysaccharidosis Type VII (MPS VII) caused by a mutation in the β-Glu gene (Gusb allele). Methods β-Glu expression of single-stranded AAV-Gusb (ssAAV-Gusb) and self-complementary AAV (scAAV-Gusb) vectors are tested with cultured murine Gusb fibroblasts. The scAAV-Gusb vector was chosen in further studies to prolong the
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Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in vivo Ocul. Surf. (IF 6.4) Pub Date : 2024-01-06 Rajiv R. Mohan, Suneel Gupta, Rajnish Kumar, Nishant R. Sinha, James Landreneau, Prashant R. Sinha, Ashish Tandon, Shyam S. Chaurasia, Nathan P. Hesemann
Purpose Corneal fibrosis and neovascularization (CNV) after ocular trauma impairs vision. This study tested therapeutic potential of tissue-targeted adeno-associated virus5 (AAV5) mediated decorin (DCN) and pigment epithelium-derived factor (PEDF) combination genes in vivo. Methods Corneal fibrosis and CNV were induced in New Zealand White rabbits via chemical trauma. Gene therapy in stroma was delivered
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Endogenous TSG-6 modulates corneal inflammation following chemical injury Ocul. Surf. (IF 6.4) Pub Date : 2023-12-25 Sudhir Verma, Isabel Y. Moreno, Cassio Prinholato da Silva, Mingxia Sun, Xuhong Cheng, Tarsis F. Gesteira, Vivien J. Coulson- Thomas
Purpose Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) is upregulated in various pathophysiological contexts, where it has a diverse repertoire of immunoregulatory functions. Herein, we investigated the expression and function of TSG-6 during corneal homeostasis and after injury. Methods Human corneas, eyeballs from BALB/c (TSG-6+/+), TSG-6+/− and TSG-6−/− mice, human immortalized corneal epithelial
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A closer look into the cellular and molecular biology of myoepithelial cells across various exocrine glands Ocul. Surf. (IF 6.4) Pub Date : 2023-12-21 Olivier Mauduit, Vanessa Delcroix, Andrew Wong, Anastasiia Ivanova, Hyun Soo Lee, Helen Makarenkova
Myoepithelial cells (MECs) are a unique subset of epithelial cells that possess several smooth muscle cell characteristics, such as a high number of actin-myosin filaments and the ability to contract. These cells are primarily located around the secretory cells of exocrine glands, including the salivary, mammary, lacrimal, and sweat glands. Their primary functions involve the construction of the basement
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Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy Ocul. Surf. (IF 6.4) Pub Date : 2023-12-21 Martin Schicht, Jessica Farger, Saskia Wedel, Marco Sisignano, Klaus Scholich, Gerd Geisslinger, Natarajan Perumal, Franz H. Grus, Swati Singh, Afsun Sahin, Friedrich Paulsen, Elke Lütjen-Drecoll
Purpose Diabetes mellitus (DM) is a leading risk factor for corneal neuropathy and dry eye disease (DED). Another common consequence of DM is diabetic peripheral polyneuropathy (DPN). Both complications affect around 50 % of the DM patients but the relationship between DM, DED and DPN remains unclear. Methods In this study, we examined mice with early onset of DM and PN after streptozotocin (STZ)-induced
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Gene expression changes in conjunctival cells associated with contact lens wear and discomfort Ocul. Surf. (IF 6.4) Pub Date : 2023-12-20 Andrés Ángel Calderón-García, Laura Valencia-Nieto, Cristina Valencia-Sandonis, Alberto López-de la Rosa, Marta Blanco-Vazquez, Itziar Fernández, Carmen García-Vázquez, Cristina Arroyo-del Arroyo, María J. González-García, Amalia Enríquez-de-Salamanca
Purpose This study aimed to analyze the differences in the expression of pain-related genes in conjunctival epithelial cells among symptomatic contact lens (CL) wearers (SCLWs), asymptomatic CL wearers (ACLWs), and non-CL wearers (non-CLWs). Methods For this study, 60 participants (20 non-CLWs, 40 CLWs) were enrolled. The CLW group comprised 20 ACLWs and 20 SCLWs according to the Contact Lens Dry Eye
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Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis Ocul. Surf. (IF 6.4) Pub Date : 2023-12-19 Huixiang Ma, Tucan Chen, Chengxu Li, Hao Xu, Qingyu Feng, Yunfei Su, Jianqiu Cai, Qingfu Zhu, Fei Liu, Liang Hu
Purpose Herpes simplex keratitis (HSK), caused by type 1 herpes simplex virus (HSV) reactivation, is a severe infectious disease that leads to vision loss. HSV can trigger metabolic reprogramming in the host cell and change the extracellular vesicles (EV) cargos; however, little is known about the EV metabolic signatures during ocular HSV infection. Here, we aimed to depict the EV-associated metabolic
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A PEDF peptide mimetic effectively relieves dry eye in a diabetic murine model by restoring corneal nerve, barrier, and lacrimal gland function Ocul. Surf. (IF 6.4) Pub Date : 2023-12-14 Shuangping Chen, Colin James Barnstable, Xiaomin Zhang, Xiaorong Li, Shaozhen Zhao, Joyce Tombran-Tink
Purpose The study investigated effectiveness of a novel PEDF peptide mimetic to alleviate dry eye-like pathologies in a Type I diabetic mouse model established using streptozotocin. Methods Mice were treated topically for 3–6 weeks with Ppx (a 17-mer PEDF mimetic) 2x/day or vehicle. Corneal sensitivity, tear film, epithelial and endothelial injury were measured using Cochet-Bonnet esthesiometer, phenol
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Dry eye disease in the young: A narrative review Ocul. Surf. (IF 6.4) Pub Date : 2023-12-07 Fiona Stapleton, Federico G. Velez, Charis Lau, James S. Wolffsohn
Dry eye disease (DED), a multifactorial ocular disease that significantly impacts quality of life, is most commonly reported in adults. This review describes the prevalence, risk factors, diagnosis and management of DED in children. A literature search, conducted from January 2000–December 2022, identified 54 relevant publications. Using similar diagnostic criteria to those reported in adults, namely
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Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjögren's syndrome: A randomized clinical trial Ocul. Surf. (IF 6.4) Pub Date : 2023-12-02 Michael Møller-Hansen, Ann-Cathrine Larsen, Anne K. Wiencke, Lene Terslev, Volkert Siersma, Tobias T. Andersen, Adam E. Hansen, Helle Bruunsgaard, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup, Tor P. Utheim, Steffen Heegaard
Purpose This double-blinded randomized clinical trial aimed to evaluate the efficacy of injecting allogeneic adipose-derived mesenchymal stem cells (ASCs) into the lacrimal gland (LG) for the treatment of dry eye disease (DED) secondary to Sjögren's syndrome (SS). Methods Fifty-four participants with severe DED secondary to SS were included and allocated to either ASCs (n = 20), vehicle (n = 20), or
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Modeling meibum secretion: Alternatives for obstructive Meibomian Gland Dysfunction (MGD) Ocul. Surf. (IF 6.4) Pub Date : 2023-12-01 Shangbang Luo, Gagik P. Djotyan, Rohan Joshi, Tibor Juhasz, Donald J. Brown, James V. Jester
Purpose While changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion. The purpose of this study was to develop a finite element model of meibum secretion and evaluate the effect of various factors that might impact meibum delivery to the eyelid. Methods A finite element analysis in
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Pipeline: Ocular biostatistics: Which is better: One or two? Ocul. Surf. (IF 6.4) Pub Date : 2023-11-22 Gary D. Novack
Abstract not available
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A new treatment changes the game: An innovative management of a child suffering from severe ligneous conjunctivitis with type 1 plasminogen deficiency Ocul. Surf. (IF 6.4) Pub Date : 2023-11-20 M. Desira, E. Gabison, P.V. Jacomet, D. Denis, F. Dalmas, T. David, A. Aziz
Abstract not available
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Corneal neuroepithelial compartmentalized microfluidic chip model for evaluation of toxicity-induced dry eye Ocul. Surf. (IF 6.4) Pub Date : 2023-11-19 Noémie Bonneau, Anaïs Potey, Michael-Adrien Vitoux, Romain Magny, Camille Guerin, Christophe Baudouin, Jean-Michel Peyrin, Françoise Brignole-Baudouin, Annabelle Réaux-Le Goazigo
Part of the lacrimal functional unit, the cornea protects the ocular surface from numerous environmental aggressions and xenobiotics. Toxicological evaluation of compounds remains a challenge due to complex interactions between corneal nerve endings and epithelial cells. To this day, models do not integrate the physiological specificity of corneal nerve endings and are insufficient for the detection
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Recent advances in age-related meibomian gland dysfunction (ARMGD) Ocul. Surf. (IF 6.4) Pub Date : 2023-11-17 Isabel Moreno, Sudhir Verma, Tarsis Ferreira Gesteira, Vivien J. Coulson- Thomas
Meibomian glands (MGs), located within the tarsal plate of the eyelid, secrete meibum which is the lipid-rich secretion necessary for stabilizing the tear film and preventing tear evaporation. Changes in the quality and quantity of meibum produced causes MG dysfunction (MGD), the leading cause of evaporative dry eye disease (EDED). MGD is an underdiagnosed disease and it is estimated that, in the US
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Impaired healing in an incision wound in corneal stroma in a lumican-null mouse Ocul. Surf. (IF 6.4) Pub Date : 2023-11-14 Eimi Suzuki, Takayoshi Sumioka, Shizuya Saika, Masayasu Miyajima, Shingo Yasuda, Hiroki Iwanishi, Yukihisa Takada, Kana Ichikawa, Jhuwala Venkatakrishnan, Chia-Yang Liu, Winston Whei-Yang Kao, Yuka Okada
Purpose We investigated healing pattern of an incisional wound in corneal stroma of lumican-null (KO) mice. Methods C57BL/6 mice (wild-type, WT) and lumican-null (knockout, KO) mice were used. A linear full-thickness incision was produced in one cornea of each mouse. After intervals of healing, the corneas were processed for the following analyses. Histology was employed to measure the distance between
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Patients with neurotrophic keratitis demonstrate alterations in ocular surface expression of transient receptor potential (TRP) channels Ocul. Surf. (IF 6.4) Pub Date : 2023-11-07 Alessandro Lambiase, Fabiana Mallone, Marta Sacchetti, Marco Segatto, Mayra Colardo, Valerio Di Martino, Alice Bruscolini
Abstract not available
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Readership awareness series – Paper 7: An overview of impact factor and other scientometrics Ocul. Surf. (IF 6.4) Pub Date : 2023-10-09 Mohammad Javed Ali, Ali Djalilian
Abstract not available
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Safety and efficacy of intense pulsed light in the treatment of severe chronic ocular graft-versus-host disease Ocul. Surf. (IF 6.4) Pub Date : 2023-10-07 He Wang, Xiaoyue Yin, Yue Li, Zhaowei Zhang, Kai Zhao, Fen Hu, Qian Liu, Qiuchen Lu, Yining Wang, Ling Zhang, Hui Jia, Jiaxin Han, Jianxin Guo, Mingxin Li
Objective To investigate the safety and efficacy of intense pulsed light (IPL) in the treatment of severe chronic ocular graft-versus-host disease (coGVHD). Methods A prospective cohort study. Seventeen patients with severe coGVHD were selected for inclusion in this study. All subjects were treated with IPL every fortnight together with conventional treatment, observation time points were pre-treatment
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Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent Ocul. Surf. (IF 6.4) Pub Date : 2023-10-07 Antonio Ballesteros-Sánchez, Concepción De-Hita-Cantalejo, María Carmen Sánchez-González, Zane Jansone-Langine, Maria Alvarez de Sotomayor, Josip Culig, José-María Sánchez-González
Perfluorohexyloctane (F6H8), a physically and chemically inert synthetic compound, has recently emerged as a promising candidate for the treatment of DED due to its unique properties. A systematic review that only include full-length randomized controlled studies (RCTs), reporting the effects of F6H8 in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement
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Greater adherence to a mediterranean diet is associated with lower C-reactive protein (CRP) levels, but not to lower odds of having dry eye disease Ocul. Surf. (IF 6.4) Pub Date : 2023-10-01 Morten Schjerven Magno, Emily Moschowits, Mathias Kaurstad Morthen, Marie Wangen Beining, Nomdo M. Jansonius, Christopher J. Hammond, Tor P. Utheim, Jelle Vehof
Purpose To investigate the hypothesis that a Mediterranean diet is associated with a lower risk of having dry eye disease (DED) in the general population. Methods DED was assessed using the Women's Health Study (WHS) dry eye questionnaire in 58,993 participants from the Dutch Lifelines Cohort with complete available dietary data (20–94 years, 60% female). Level of adherence to a traditional Mediterranean
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New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering Ocul. Surf. (IF 6.4) Pub Date : 2023-09-28 Swati Singh, Zoltan Winter, Fabian Necker, Tobias Bäuerle, Michael Scholz, Lars Bräuer, Friedrich Paulsen
Purpose To study the tissue architecture, isthmus (connection between two lobes) of the lacrimal gland using preclinical 7T MRI in combination with histology and electron microscopy. Methods Ten lacrimal glands from Caucasian body donors (mean age 78.7 years) were studied using 7T-MRI (N = 5; scanned at 75-μm intervals), histology, and electron microscopy (N = 5) and 3D cinematic rendering (CR) techniques
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Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells Ocul. Surf. (IF 6.4) Pub Date : 2023-09-26 Menglu Yang, Vanessa Delcroix, Anton Lennikov, Nicholas Wang, Helen P. Makarenkova, Darlene A. Dartt
Purpose Primary Sjögren's syndrome (pSS) is an autoimmune disease that mainly attacks the lacrimal glands causing severe aqueous-deficient dry eye. Clinical evidence indicates the DNA sensing mechanism in the pathogenesis of pSS. The purpose of the present study is to determine the pro-inflammatory effect of self-genomic DNA (gDNA) on myoepithelial cells (MECs), which along with acinar and ductal cells
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Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing Ocul. Surf. (IF 6.4) Pub Date : 2023-09-22 Sudhir Verma, Fernando T. Ogata, Isabel Y. Moreno, Cassio Prinholato da Silva, Tainah Dorina Marforio, Matteo Calvaresi, Mehmet Sen, Vivien J. Coulson-Thomas, Tarsis Ferreira Gesteira
Purpose Lumican is a major extracellular matrix (ECM) component in the cornea that is upregulated after injury and promotes corneal wound healing. We have recently shown that peptides designed based on the 13 C-terminal amino acids of lumican (LumC13 and LumC13C-A) are able to recapitulate the effects of lumican on promoting corneal wound healing. Herein we used computational chemistry to develop peptide
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Intrastromal versus subconjunctival injection of mesenchymal stem/stromal cells for promoting corneal repair Ocul. Surf. (IF 6.4) Pub Date : 2023-09-25 Mohammad Soleimani, Reza Mirshahi, Kasra Cheraqpour, Seyed Mahbod Baharnoori, Hamed Massoumi, Collin Chow, Sumaiya Shahjahan, Bita Momenaei, Mohammad Javad Ashraf, Raghuram Koganti, Mahmood Ghassemi, Khandaker N. Anwar, Elmira Jalilian, Ali R. Djalilian
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Evaluation of ocular neuropathic pain Ocul. Surf. (IF 6.4) Pub Date : 2023-09-23 Damien Tuan-Man Le, Himal Kandel, Stephanie L. Watson
Aim To identify and assess the quality of current validated questionnaires that could be used to evaluate ocular neuropathic pain and its associated aetiologies. Methods A literature search was performed on MEDLINE, PubMed, EMBASE, PsycINFO and The Cochrane Library. Articles evaluating questionnaires for ocular neuropathic pain and its associated aetiologies were included. Data on psychometric properties
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Murine models of graft versus host disease (GVHD): Focus on ocular GVHD Ocul. Surf. (IF 6.4) Pub Date : 2023-09-22 Philipp Steven, Victor L. Perez, Ajay Sharma
Graft versus host disease (GVHD) remains a major and serious complication of allogeneic hematopoietic stem cell transplantation. Based on the time of onset, clinical phenotypes, progression kinetics, and pathophysiology, GVHD is stratified into acute, chronic, and overlapping types. The eyes are among the most commonly affected organs in GVHD. Mouse models have played an important role in understanding
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Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration Ocul. Surf. (IF 6.4) Pub Date : 2023-09-09 Filippo Bonelli, Ibrahim Demirsoy, Romina Mayra Lasagni Vitar, Philippe Fonteyne, Giulio Ferrari
Purpose To test long-term ocular toxicity and analgesic/anti-inflammatory efficacy of two novel ocular formulations of neurokinin 1 receptor (NK1R) antagonist Aprepitant. Methods for toxicity studies, two Aprepitant formulations (X and Y) were tested on C57BL/6 N mice. Gold standards were 0.4% Oxybuprocaine, 0.1% Diclofenac, or saline. For efficacy studies, C57BL/6 N mice underwent corneal alkali burn
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Conjunctival transcriptomics in ocular mucous membrane pemphigoid Ocul. Surf. (IF 6.4) Pub Date : 2023-09-09 Jesse Panthagani, Kusy Suleiman, Rachel C. Vincent, Hon Shing Ong, Graham R. Wallace, Saaeha Rauz
Purpose Ocular Mucous Membrane Pemphigoid (OcMMP) is an orphan disease characterized by chronic autoimmune-driven conjunctival inflammation leading to progressive scarring, debilitating symptoms, and blinding sequelae. This feasibility study aims to demonstrate conjunctival genetic transcriptomic analyses as a putative tool for interrogation of pathogenic signaling pathways in OcMMP. Methods Conjunctival
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Retinol palmitate in management of chronic Steven-Johnson Syndrome with ocular surface keratinization Ocul. Surf. (IF 6.4) Pub Date : 2023-09-07 Ananya Parampalli Ravindra, Rajesh Sinha, Aafreen Bari, T. Velpandian, Seema Sen, Tushar Agarwal, Namrata Sharma, Jeewan Singh Titiyal
Purpose To study the outcomes of topical Retinol Palmitate ophthalmic solution in chronic Stevens-Johnson Syndrome with ocular surface keratinisation. Methods It was a comparative interventional study conducted at Rajendra Prasad Centre for Ophthalmic Sciences, Delhi, India from 2020 to 2022 evaluating outcomes of addition of topical Retinol Palmitate to conventional treatment objectively as well as
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A review of the epithelial and stromal effects of corneal collagen crosslinking Ocul. Surf. (IF 6.4) Pub Date : 2023-09-06 Samantha Bradford, Shangbang Luo, Donald Brown, Tibor Juhasz, James Jester
Induced corneal collagen crosslinking and mechanical stiffening via ultraviolet-A photoactivation of riboflavin (UVA CXL) is now a common treatment for corneal ectasia and Keratoconus. Some effects of the procedure such as induced mechanical stiffening, corneal flattening, and cellular toxicity are well-known, but others remain more controversial. Authors report a variety of contradictory effects,
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Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas Ocul. Surf. (IF 6.4) Pub Date : 2023-08-30 Kristen L. Segars, Vickery Trinkaus-Randall
Maintaining the clarity of the cornea is essential for vision, and is achieved through an exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the identity and modifications of the glycosaminoglycans (GAGs) are seen both throughout the normal wound healing process and in pathological conditions resulting in corneal opacity. Understanding these changes has been
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Neurotrophic keratopathy: An updated understanding Ocul. Surf. (IF 6.4) Pub Date : 2023-09-04
Purpose To propose an updated definition and staging system for neurotrophic keratopathy (NK) and provide consensus on diagnosis and treatment. Methods A study group was convened to review the data pertinent to NK using a modified nominal group process. They proposed an updated definition for NK and a new 6-step staging system (Neurotrophic Keratopathy Study Group [NKSG] Classification) that can be
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TFOS Lifestyle Report Executive Summary: A Lifestyle Epidemic - Ocular Surface Disease Ocul. Surf. (IF 6.4) Pub Date : 2023-09-01 Jennifer P. Craig, Monica Alves, James S. Wolffsohn, Laura E. Downie, Nathan Efron, Anat Galor, José Alvaro P. Gomes, Lyndon Jones, Maria Markoulli, Fiona Stapleton, Christopher E. Starr, Amy Gallant Sullivan, Mark D.P. Willcox, David A. Sullivan
The Tear Film & Ocular Surface Society (TFOS) Workshop entitled ‘A Lifestyle Epidemic: Ocular Surface Disease’ was a global initiative undertaken to establish the direct and indirect impacts of everyday lifestyle choices and challenges on ocular surface health. This article presents an executive summary of the evidence-based conclusions and recommendations of the 10-part TFOS Lifestyle Workshop report
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Diagnostic capacity for fungal keratitis in Africa – Survey in 50 African countries Ocul. Surf. (IF 6.4) Pub Date : 2023-09-01 Jean Claude Makangara Cigolo, Rita O. Oladele, Stephen B. Kennedy, Michelle Bignoumba, Hassane Mahamat Hassane, Victor Bucumi, Guyguy Kamwiziku, Stephen Kojo Eduful, Alice Afonso Manjate, Sahra Isse Mohamed, Furahini Mbise, Mutinta E. Shisholeka, Richard O.S. Penney, Emma Orefuwa, David W. Denning
Abstract not available
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Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction Ocul. Surf. (IF 6.4) Pub Date : 2023-08-22 Guoliang Wang, Lina Xu, Ruize Shi, Yingyue Ye, Baihui Zeng, Xiuqin Yang, Zeyu Liu, Zhen Liu, Shurong Wang, Yuhua Xue, Cheng Li
Purpose Meibomian glands (MGs) are crucial for maintaining tear film stability and ocular surface health. Here, we aim to establish a novel organotypic culture model of MGs and explore the risk factors of MG dysfunction (MGD). Methods We developed a novel organotypic culture model for MGs at the air-liquid interface. The viability and cell proliferation of MGs were assessed using CCK-8, immunofluorescence
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TNF is a critical cytokine in age-related dry eye disease Ocul. Surf. (IF 6.4) Pub Date : 2023-08-25 Yashaswini Kelagere, Kaitlin K. Scholand, Erica N. DeJong, Andrea I. Boyd, Zhiyuan Yu, Roger A. Astley, Michelle C. Callegan, Dawn ME. Bowdish, Helen P. Makarenkova, Cintia S. de Paiva
Aging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated
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A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells Ocul. Surf. (IF 6.4) Pub Date : 2023-08-25 Lina Xu, Guoliang Wang, Ruize Shi, Baihui Zeng, Yan Zhang, Zhen Liu, Shurong Wang, Nuo Dong, Cheng Li
Purpose The conjunctival epithelial cells cultured with bovine serum or feeder cells were not suitable for clinical application. Therefore, we developed a novel serum-free and feeder cell-free culture system containing only a cocktail of three chemicals (3C) to expand the conjunctival epithelial cells. Methods The cell proliferative ability was evaluated by counting, crystal violet staining and Ki67
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Dry eye disease sustainability Ocul. Surf. (IF 6.4) Pub Date : 2023-08-22 Francesc March de Ribot, Jose M. Benitez Del Castillo, Gerd Geerling, Elisabeth M. Messmer, Christophe Baudouin, Monica Alves
Abstract not available
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Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test Ocul. Surf. (IF 6.4) Pub Date : 2023-08-16 Saumya Srivastav, Sayan Basu, Swati Singh
Purpose To assess the real-time changes in the tear film and ocular surface of symptomatic video display terminal (VDT) versus asymptomatic users. Methods A total of 35 symptomatic (29 ± 5.6 years; Group 1, mild dry eye disease) and 35 asymptomatic (24.1 ± 4.6 years; Group 2) VDT users with a mean OSDI of 28 ± 11 and 0.86 ± 2.1, respectively, had tear film examination (Oculus Keratograph 5 M and Tearlab
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Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery Ocul. Surf. (IF 6.4) Pub Date : 2023-08-03 Satinder Kaur, Peri Sohnen, Sudha Swamynathan, Yiqin Du, Edgar M. Espana, Shivalingappa K. Swamynathan
The structural and functional integrity of the ocular surface, a continuous epithelial structure comprised of the cornea, the conjunctiva, and the ductal surface of the lacrimal as well as meibomian glands, is crucial for proper vision. The ocular surface barrier function (OSBF), sum of the different types of protective mechanisms that exist at the ocular surface, is essential to protect the rest of
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Clinical trials submissions to The Ocular Surface Ocul. Surf. (IF 6.4) Pub Date : 2023-08-06 Gary D. Novack, Cintia S. de Paiva
Abstract not available