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Correction to: Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine Inflammopharmacology (IF 3.238) Pub Date : 2021-01-04 Fatma Tannich, Asma Tlili, Coralie Pintard, Amina Chniguir, Bruno Eto, Pham My-Chan Dang, Ouajdi Souilem, Jamel El-Benna
Actually, the same mice brain extracts were used in both figures, and we thought it was more accurate to check whether in the same mice brain extracts used.
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Chemical characterization and anti-arthritic appraisal of Monotheca buxifolia methanolic extract in Complete Freund’s Adjuvant-induced arthritis in Wistar rats Inflammopharmacology (IF 3.238) Pub Date : 2021-01-02 Muhammad Furqan Akhtar, Khushdil Khan, Ammara Saleem, Mirza Muhammad Faran Ashraf Baig, Azhar Rasul, Mohamed M. Abdel-Daim
The current study was designed to evaluate the anti-oxidant and anti-arthritic potential of a traditionally used herb, Monotheca buxifolia. The M. buxifolia methanolic extract (MBME) was prepared from the aerial parts of the plant followed by chemical characterization with GC–MS. The anti-oxidant potential of the MBME was demonstrated by DPPH scavenging activity. The effects of MBME on protein denaturation
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Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation Inflammopharmacology (IF 3.238) Pub Date : 2021-01-01 Sree Lalitha Bojja, Bikash Medhi, Shashi Anand, Alka Bhatia, Rupa Joshi, Ranjana W. Minz
The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective properties in numerous studies. The current study attempts to investigate the effect
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Pharmacodynamic mechanisms of anti-inflammatory drugs on the chemosensitization of multidrug-resistant cancers and the pharmacogenetics effectiveness Inflammopharmacology (IF 3.238) Pub Date : 2020-10-17 Neda Gholamian Dehkordi, Seyed Abbas Mirzaei, Fatemeh Elahian
Drug resistance as a remarkable issue in cancer treatment is associated with inflammation which occurs through complex chemical reactions in the tumor microenvironment. Recent studies have implicated that glucocorticoids and NSAIDs are mainly useful combinations for inflammatory response modulation in chemotherapeutic protocols for cancer treatment. Immunosuppressive actions of glucocorticoids and
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Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-α, NF-κB, ILs, and COX-2 activities in in vivo models Inflammopharmacology (IF 3.238) Pub Date : 2020-10-16 Mohammad Saleem, Anam Iftikhar, Muhammad Asif, Khalid Hussain, Alamgeer, Pervaiz Akhtar Shah, Ammara Saleem, Muhammad Furqan Akhtar, Muhammad Tanzeem, Hafiza Sidra Yaseen
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Neuroinflammatory responses in Parkinson’s disease: relevance of Ibuprofen in therapeutics Inflammopharmacology (IF 3.238) Pub Date : 2020-10-14 Ashish Singh, Pratibha Tripathi, Sarika Singh
Parkinson’s disease (PD) pathogenesis inevitably involves neuroinflammatory responses attained through contribution of both neuron and glial cells. Investigation done in both experimental models of PD and in samples of PD patients suggested the involvement of both central and peripheral inflammatory responses during PD pathogenesis. Such neuroinflammatory responses could be regulated by neuron-glia
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Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1 Inflammopharmacology (IF 3.238) Pub Date : 2020-10-13 Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Yang Liu, Weishuai Bian, Wei Chen
Acute pancreatitis (AP) is a common acute abdominal disease with high mortality and mortality rates. Increasing evidences clarified that Traditional Chinese Medicine (TCM) adjuvant therapy for AP can be used and it gives a positive effect. Quercetin (3,3′,4′,5,7-pentahydroxyflavone, QE) is a type of flavone compound with positive effect on cancer and inflammation prevention. The current study aims
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Memantine and Ibuprofen pretreatment exerts anti-inflammatory effect against streptozotocin-induced astroglial inflammation via modulation of NMDA receptor-associated downstream calcium ion signaling Inflammopharmacology (IF 3.238) Pub Date : 2020-10-07 Sandeep K. Mishra, Mahendra Hidau, Shivika Rai
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Innate immune response in systemic autoimmune diseases: a potential target of therapy Inflammopharmacology (IF 3.238) Pub Date : 2020-10-02 Alireza Hejrati, Alireza Rafiei, Mohsen Soltanshahi, Shahnaz Hosseinzadeh, Mina Dabiri, Mahdi Taghadosi, Saeid Taghiloo, Davood Bashash, Fatemeh Khorshidi, Parisa Zafari
Innate immunity refers to defense mechanisms that are always present, ready to combat microbes and other offending agents. Innate immunity acts as a first-line defense and activates the conventional immune responses; however, it has been speculated that the importance of innate immunity in initiation and development of some disorders is more than just the “first line of defense”. Autoimmune diseases
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Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages Inflammopharmacology (IF 3.238) Pub Date : 2020-10-01 Chun-Ying Qiao, Ying Li, Yue Shang, Min Jiang, Jian Liu, Zi-Ying Zhan, Huan Ye, Yong-Ce Lin, Jing-Ya Jiao, Rong-Hui Sun, Zhi-Hong Zhang, Mei-Hua Piao, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian
Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammation. Treated with lipopolysaccharide (LPS) plus MSU, both mouse peritoneal macrophages
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Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-21 Xiao-Jing Lin,Ruoxu Liu,Chenyi Li,Xueqing Yi,Bo Fu,M J Walker,Xiao-Ming Xu,Gang Sun,Cheng-Hsien Lin
We aimed to elucidate the role of cortical and hippocampal dendritic spines on neurological deficits associated with hippocampal microgliosis, hippocampal neurogenesis, and neuroinflammation in mice with cortical compact impact (CCI) injury. In the present study, we found that CCI reduced spatial memory mean latency (10 s. vs 50 s) and motor dysfunction (130 s. vs 150 s.) in mice, as determined by
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Current and novel therapeutic targets in the treatment of rheumatoid arthritis. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-18 Genu George,G L Shyni,K G Raghu
Rheumatoid arthritis (RA), a multifactorial disease characterized by synovitis, cartilage destruction, bone erosion, and periarticular decalcification, finally results in impairment of joint function. Both genetic and environmental factors are risk factors in the development of RA. Unwanted side effects accompany most of the current treatment strategies, and around 20–40% of patients with RA do not
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Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-16 L M S Elisei,T R Moraes,I H Malta,I Charlie-Silva,I M O Sousa,F P Veras,M A Foglio,L F Fraceto,G Galdino
Artemisinin (ART) was initially described for the control of inflammation and pain. However, the mechanisms involved with its antinociceptive effect are still poorly understood. Thus, this present study aimed to investigate the effect of ART in both free and nanocapsulated form on postoperative pain, as well as the participation of the spinal Toll-like receptor 4 (TLR4) in this process. Postoperative
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Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-15 Sahar M Jaffal,Sawsan A Oran,Mohammad Alsalem
Arbutus andrachne L. is a medicinal plant that grows in Jordan and has many valuable effects. In the present study, the anti-nociceptive effect of A. andrachne methanolic leaf extract was determined in mice using thermal and chemical tests. Our findings show that different doses of A. andrachne extract reduced the number of writhings significantly compared to control group. The leaf extract also reduced
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Alzheimer's disease: natural products as inhibitors of neuroinflammation. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-15 Olumayokun A Olajide,Satyajit D Sarker
Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory
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Actions of Cannabis sativa L. fixed oil and nano-emulsion on venom-induced inflammation of Bothrops moojeni snake in rats. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-14 Helison de Oliveira Carvalho,Danna Emanuelle Santos Gonçalves,Karyny Roberta Tavares Picanço,Abrahão Victor Tavares de Lima Teixeira Dos Santos,Maria Lucia,Xuebo Hu,Caio Pinho Fernandes,Irlon Maciel Ferreira,José Carlos Tavares Carvalho
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ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-12 Mina T Kelleni
During the COVID-19 pandemic, a correspondence, published at the Lancet Respiratory Medicine, that linked angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and ibuprofen to a higher risk of SARS CoV-2 infection and complications, has influenced, when adopted by official health authorities, the practical management of COVID-19 with regard to non-steroidal anti-inflammatory drugs
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Effect of canakinumab on clinical and biochemical parameters in acute gouty arthritis: a meta-analysis. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-12 Monalisa Jena,Amruta Tripathy,Archana Mishra,Rituparna Maiti
Background Targeted anti-IL-1β therapy may be a valuable option for the management of gouty arthritis. The present meta-analysis has evaluated the effect of canakinumab, an anti-IL-1β monoclonal antibody in gouty arthritis. Methods A standard meta-analysis protocol was developed and after performing a comprehensive literature search in MEDLINE, Cochrane, and International Clinical Trial Registry Platform
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Halodule pinifolia (Seagrass) attenuated lipopolysaccharide-, carrageenan-, and crystal-induced secretion of pro-inflammatory cytokines: mechanism and chemistry. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-12 Sajeli Ahil Begum,Kirti Hira,Pragya Paramita Pal,Samrun Nessa,Onkar P Kulkarni,Jeyapragash Danaraj,Ameer Basha Shaik,Hiroshi Araya,Yoshinori Fujimoto
Objectives The study aimed to explore the anti-inflammatory effect, underlying mechanism, and chemistry of Halodule pinifolia extract. Methods The ethyl acetate (EHP) and methanol (MHP) extracts of Halodule pinifolia were screened for pro-inflammatory cytokine inhibition effect under various in vitro (LPSand crystal-induced inflammation) and in vivo models (LPS-induced endotoxaemia model, carrageenan-induced
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Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-10 Mariam I Gamal El-Din,Fadia S Youssef,Riham S Said,Mohamed L Ashour,Omayma A Eldahshan,Abdel Nasser B Singab
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MiR-200a inversely correlates with Hedgehog and TGF-β canonical/non-canonical trajectories to orchestrate the anti-fibrotic effect of Tadalafil in a bleomycin-induced pulmonary fibrosis model. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-10 Suzan M Mansour,Hanan S El-Abhar,Ayman A Soubh
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Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology (IF 3.238) Pub Date : 2020-09-10 Roberto Mikio Kassuya,Joyce Alencar Santos Radai,Luis Fernando Benitez Macorini,Viktor Krejci Nunes,Marcos José Salvador,Patricia Regina Terço Leite,Rodrigo Juliano Oliveira,Júlio Croda,Arielle Cristina Arena,Cândida Aparecida Leite Kassuya
Information on the health benefits of ethanolic extracts obtained from Blutaparon portulacoides stem (EEBP) hasn´t been consistently described in the literature until the present moment. This study investigated the antimycobacterial, anti-inflammatory and toxicological effects of EEBP in models of inflammation/infection, as well as its chemical composition. Chemical analysis of EEBP by electrospray
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COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties. Inflammopharmacology (IF 3.238) Pub Date : 2020-08-14 Muhammad Asif,Mohammad Saleem,Malik Saadullah,Hafiza Sidra Yaseen,Raghdaa Al Zarzour
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A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality. Inflammopharmacology (IF 3.238) Pub Date : 2020-08-14 Lucinda Smart,Neil Fawkes,Paul Goggin,Graham Pennick,K D Rainsford,Bruce Charlesworth,Neil Shah
The coronavirus disease 19 (COVID-19) pandemic is currently the most acute healthcare challenge in the world. Despite growing knowledge of the nature of Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), treatment options are still poorly defined. The safety of non-steroidal anti-inflammatory drugs (NSAIDs), specifically ibuprofen, has been openly questioned without any supporting evidence
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Salt-dependent hypertension and inflammation: targeting the gut-brain axis and the immune system with Brazilian green propolis. Inflammopharmacology (IF 3.238) Pub Date : 2020-08-12 Marcos Adriano Carlos Batista,Daiane Cristina de Assis Braga,Sandra Aparecida Lima de Moura,Gustavo Henrique Bianco de Souza,Orlando David Henrique Dos Santos,Leonardo Máximo Cardoso
Systemic arterial hypertension (SAH) is a major health problem around the world and its development has been associated with exceeding salt consumption by the modern society. The mechanisms by which salt consumption increase blood pressure (BP) involve several homeostatic systems but many details have not yet been fully elucidated. Evidences accumulated over the last 60 decades raised the involvement
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Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways. Inflammopharmacology (IF 3.238) Pub Date : 2020-08-12 Eman M Elbaz,Hebat Allah A Amin,Ahmed S Kamel,Sherehan M Ibrahim,Hebatullah S Helmy
Benign prostatic hyperplasia (BPH) is a nonmalignant enlargement of the prostate common in older men. Diallyl sulfide (DAS), a major component of garlic, has been reported to possess antioxidant, anti-inflammatory, and antiproliferative effects. However, the underlying protective immunomodulatory mechanism of DAS on BPH remains vague. Herein, experimental BPH was induced in rats by daily subcutaneous
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The advances of methotrexate resistance in rheumatoid arthritis. Inflammopharmacology (IF 3.238) Pub Date : 2020-08-05 Jun Yu,Peng Zhou
Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and basic pharmacological research. In several observational studies, MTXR, and treatment
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Correction to: Evaluation of in vivo anti-inflammatory and anti-angiogenic attributes of methanolic extract of Launaea spinosa. Inflammopharmacology (IF 3.238) Pub Date : 2020-08-03 Muhammad Asif,Mahrukh,Malik Saadullah,Hafiza Sidra Yaseen,Mohammad Saleem,Hafiz Muhammad Yousaf,Ikram Ullah Khan,Maria Yaseen,Muhammad Usman Shams
Unfortunately, a section under the heading “Materials and Method” has been published with errors.
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TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement. Inflammopharmacology (IF 3.238) Pub Date : 2020-07-21 Hyeonyoul Lee,Heungdeok Kim,Jinwon Seo,Kyoungbaek Choi,Yunsin Lee,Kiwon Park,Sujeong Kim,Ali Mobasheri,Heonsik Choi
Osteoarthritis (OA) is the most common form of arthritis, characterized by cartilage destruction, pain and inflammation in the joints. Existing medications can provide relief from the symptoms, but their effects on the progression of the disease are limited. TissueGene-C (TG-C) is a novel cell and gene therapy for the treatment of OA, comprising a mixture of human allogeneic chondrocytes and irradiated
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Reduced cutaneous inflammation associated with antioxidant action after topical application of the aqueous extract of Annona muricata leaves. Inflammopharmacology (IF 3.238) Pub Date : 2020-07-09 Luana M Cercato,Jéssica M D Araújo,Alan S Oliveira,Allan J O Melo,Bruno S Lima,Edmilson W P Dos Santos,Agenor G Dos S Neto,Ricardo L C de Albuquerque-Júnior,Marcelo C Duarte,Adriano A S Araujo,Ana Mara O Silva,Renata Grespan,Cristiane B Correa,Enilton A Camargo
Annona muricata L. is used in folk medicine for treatment of diseases related to inflammatory and oxidative processes. This study investigated the effect of the aqueous extract of A. muricata leaves (AEAM) on TPA-induced ear inflammation and antioxidant capacity, both in vitro and in vivo. The in vitro antioxidant capacity of AEAM was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing/antioxidant
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A viral infection explanation for Kawasaki disease in general and for COVID-19 virus-related Kawasaki disease symptoms. Inflammopharmacology (IF 3.238) Pub Date : 2020-07-07 Kevin Roe
SARS-CoV-2, a new virus that appeared in Wuhan, China, in 2019 has approximately an 80% genomic match to the Severe Acute Respiratory Symptom (SARS) virus, which is known to come from a bat virus. Symptoms of Kawasaki disease in general and incomplete Kawasaki disease have been seen in a subset of pediatric patients having a current or previous infection of SARS-CoV-2. A viral infection, such as a
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Anti-inflammatory effect of stevioside abates Freund's complete adjuvant (FCA)-induced adjuvant arthritis in rats. Inflammopharmacology (IF 3.238) Pub Date : 2020-07-02 Sateesh Alavala,Nasiruddin Nalban,Rajendra Sangaraju,Madhusudana Kuncha,Mahesh Kumar Jerald,Eswar Kumar Kilari,Ramakrishna Sistla
Adjuvant arthritis is a chronic, autoimmune and inflammatory disorder of the joints. The occurrence of disorder causes a severe damage to the connective tissue eventually leading to progressive physical disability and eventual death. The recent years of evidence suggests the anti-inflammatory properties of stevioside, a diterpene glycoside. However, the effect of stevioside against adjuvant arthritis
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Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation. Inflammopharmacology (IF 3.238) Pub Date : 2020-07-02 Juriyati Jalil,Ali Attiq,Chiew Chia Hui,Lui Jin Yao,Nurul Aimi Zakaria
The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternatives in this scenario. Genus Uvaria is a part of Annonaceae family, while the majority
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Correction to: 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-29 Cay-Huyen Chen,Ping-Chen Shih,Han-Yu Lin,Po-Kai Wang,Po-Ting Pan,Ching-Wei Chuang,Ming-Chang Kao
Unfortunately, Fig. 5 was incorrectly published in the original publication. The complete corrected Fig. 5 is given below.
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Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-28 Pei Liu,Jianjun Cheng,Shuai Ma,Jianyu Zhou
Neuropathic pain remains one of the most common pain conditions worldwide. Accumulating evidence shows that activation of the NOD-like receptor protein 3 (NLRP3) inflammasome contributes to the pathogenesis of neuropathic pain, although the role of the NLRP3 inflammasome in neuropathic pain has not yet been fully elucidated. In animal models of neuropathic pain, paeoniflorin (PF) was shown to have
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Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-27 Sameh Saber,Eman M Abd El-Kader
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder, which has an increased incidence worldwide. The NLRP3 inflammasome has recently been assigned as a promising target for several inflammatory diseases including bowel inflammation. We aimed to investigate the potential complementary effects of combined therapy of metformin and MCC950 in dextran sodium sulfate (DSS)-induced colitis
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Accelerated ageing profile in inflammatory arthritis is unique and tissue compartment specific. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-27 K S Ross,Y S L Powrie,C Smith
Rheumatoid arthritis is prevalent in more than 1% of the global population, with the highest occurrence between ages 35 and 50, which places a huge burden on the economy. Drug discovery for the prevention of this chronic disease is; therefore, a priority. It is known that subclinical progression of many chronic non-communicable diseases is exacerbated via accelerated ageing, a pro-inflammatory phenotype
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Oral administration of Centella asiatica (L.) Urb leave aqueous extract ameliorates cerebral oxidative stress, inflammation, and apoptosis in male rats with type-2 diabetes. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-25 Nelli Giribabu,Kamarulzaman Karim,Eswar Kumar Kilari,Srinivasa Rao Nelli,Naguib Salleh
Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica leave aqueous extract (C. asiatica) (50, 100, and 200 mg/kg/b.w.) were given to diabetic
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Empagliflozin suppresses inflammation and protects against acute septic renal injury. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-20 Zaid H Maayah,Mourad Ferdaoussi,Shingo Takahara,Shubham Soni,Jason R B Dyck
Background Sepsis-induced systemic inflammation response syndrome is the leading cause of morbidity and mortality among patients in intensive care units in North America. While sepsis is associated with multiple organ damage, acute renal injury represents a hallmark of sepsis. Since systemic and renal inflammation is known to play a vital role in morbidity and mortality associated with sepsis, identifying
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Antinociceptive effect of Lonchocarpus araripensis lectin: activation of L-arginine/NO/cGMP/K+ATP signaling pathway. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-15 Ana Maria S Assreuy,Renata Morais Ferreira Amorim,Stephanie Lian Martins,Maria Gleiciane de Queiroz Martins,João Batista Cajazeiras,Mayara Torquato Lima da Silva,Alana Freitas Pires,Kyria Santiago Nascimento,Benildo Sousa Cavada,Mário Rogério Lima Mota
Objective and design The involvement of nitric oxide pathway in the antinociceptive activity of Lonchocarpus araripensis lectin (LAL) was investigated in the model of carragenan-induced hypernociception. Methods Swiss mice received LAL (0.01–10 mg/kg; i.v.) 30 min before s.c. injection of carragenan in the paws. For the involvement of nociceptive pathways, animals were previously treated with the blockers:
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Retraction Note: Selected TLR7/8 agonist and type I interferon (IFN‑α) cooperatively redefine the microglia transcriptome. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-15 Mst Reshma Khatun,Sarder Arifuzzaman
Since publication, it has become apparent that there are major errors in the qRT-PCR data presented.
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Design, synthesis and pharmacological assessment of new pyrazole compounds. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-11 Jordana C Oliveria,Daiany P B Silva,Iziara F Florentino,Lidya C da Silva,Germán Sanz,Boniek G Vaz,Francine Pazini,Flávio S de Carvalho,Luciano M Lião,Thaís Rosa Marques Dos Santos,Marize C Valadares,Elson A Costa,Fernanda Cristina Alcantara Dos Santos,Bianca Villavicencio,Hugo Verli,Ricardo Menegatti
AimsThis study investigated the antinociceptive and anti-inflammatory effects of new pyrazole compounds LQFM011(5), LQFM043(6) and LQFM044(7) as well as the mechanisms of action and acute in vitro toxicity. Main methodsThe antinociceptive activity was evaluated using the acetic acid-induced abdominal writhing test, formalin-induced pain test and the Randall–Selitto test. The anti-inflammatory activity
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Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-09 Rasool Haddadi,Rojin Rashtiani
BackgroundMany injuries cause pain and inflammation, which are one of the major challenges for physicians. In this study, the analgesic and the anti-inflammatory effects of milnacipran were investigated on carrageenan-induced nociception and inflammation in male rats. MethodsPain and inflammation were induced by injection of λ-carrageenan (1% v/v) into the hind paw. Indomethacin (10 mg/kg: ip) or milnacipran
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Preoperative meloxicam versus postoperative meloxicam for pain control, patients' satisfaction and function recovery in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-06 Lingyun Ren,Li Meng,Hong Yan,Wei Sun,Dan Yao
This study aimed to compare the analgesic effect, patients’ satisfaction, tolerance and hip-joint function recovery by preoperative meloxicam versus postoperative meloxicam in treating hip osteoarthritis (OA) patients receiving total hip arthroplasty (THA). 132 hip OA patients who underwent THA surgery were allocated into postoperative analgesia (POST) and preoperative analgesia (PRE) groups at a 1:1
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LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-05 Ilknur Calik,Muhammed Yayla,Irfan Cinar,Elif Cadirci,Abdulmecit Albayrak,Busra Sirin,Muhammet Calik,Zekai Halici
AimThis study aimed to demonstrate the role of serotonin 7 receptor (5-HT7) and the effects of 5-HT7 agonists and antagonists in an indomethacin-induced gastric ulcer. Material and methodMale albino Wistar rats (n = 60) were used in the experiments. LP44 (5-HT7 agonist) and SB269970 (5-HT7 antagonist) were administered at 10 mg/kg as a pre-treatment. One hour after the drug treatments, 25 mg/kg of
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The protective effect of Sophora japonica on prostatic hypertrophy and inflammation in rat. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-05 Ahmed Elberry,Shagufta Mufti,Jaudah Al-Maghrabi,Salah Ghareib,Hisham Mosli,Ali El-Halawany,Essam Abdel-Sattar
The atypical adenomatous hyperplasia (AAH) is invariably an incidental histological change, with no clinical findings specific for its diagnosis, and the mean patient age at diagnosis is 64–70 years. The incidence of AAH varies between 1.5 and 19.6% of transurethral resections and in up to 33% of radical prostatectomies. Herbal medicines are becoming a popular option in the treatment of prostatic-related
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Editorial Special Section: "Commemorating Leading Inflammo-Pharmacologists" : Commemorating the life at 90 years and work of Professor Michael Wellesley Whitehouse, BA, MSc, D Phil, F.R.I.C., FRSB (UK) KSJ. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-03 Kim Drummond Rainsford
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Perindopril ameliorates experimental Alzheimer's disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling. Inflammopharmacology (IF 3.238) Pub Date : 2020-06-01 Basim A S Messiha,Mohammed R A Ali,Mahmoud M Khattab,Amira M Abo-Youssef
Accumulating evidence indicates that over-stimulation of angiotensin-converting enzyme 1 (ACE1) activity is associated with β-amyloid (Aβ) and phosphorylated tau (p-tau)-induced apoptosis, oxido-nitrosative neuroinflammatory stress and neurodegeneration in Alzheimer’s disease (AD). Alternatively, activation of the ACE2, the metalloprotease neprilysin (Neutral Endopeptidase; NEP) and the insulin-degrading
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Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balance. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-29 Kai Zheng,Jia Jia,Shihai Yan,Hong Shen,Ping Zhu,Jiangyi Yu
Immunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (TH17) cells and regulatory T cells (Treg cells) is involved in ulcerative colitis (UC) pathogenesis. Dendritic cells (DCs) are able to induce T cell differentiation. Paeoniflorin (PF) is a monoterpene glucoside that is commonly used for treatment of autoimmune disease
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Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-16 Olumayokun A Olajide,Idowu S Akande,Carlos da Silva Maia Bezerra Filho,Izabela Lepiarz-Raba,Damião Pergentino de Sousa
Methyl 3,4,5-trimethoxycinnamate (MTC) is a bioactive natural phenylpropanoid. We evaluated anti-inflammatory effects of synthetic MTC in RAW264.7 macrophages and RAW264.7-3T3-L1 adipocytes co-culture. Levels of cytokines and chemokines, as well as NO and PGE2 in cell supernatants were analysed using ELISAs, Griess assay and enzyme immunoassays, respectively. In-cell cytoblot was used to assess levels
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Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-16 Yu Yuan,Weidong Men,Xiaosong Shan,Hexin Zhai,Xiaoxia Qiao,Lianting Geng,Chunhui Li
ischaemic stroke accounts for almost 11% of all deaths worldwide and has a high incidence of permanent disability among patients. Baicalein has many beneficial pharmacological properties, including anti-inflammatory and anti-oxidant effects. However, the neuroprotective effect of baicalein is still unclear. The current study scrutinizes the neuroprotective effect of baicalein against the ischaemic/reperfusion
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Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-15 Naveet Pannu,Archana Bhatnagar
AbstractSystemic lupus erythematosus is a multisystem autoimmune disease. Apart from usual treatments, approximately 50% of lupus patients use complementary medicine. Resveratrol is a phytoalexin with various pharmacological properties. We hypothesised that prophylactic treatment with resveratrol may abrogate manifestations in pristane-induced murine model of lupus-like disease and piperine; a bio-enhancer
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Methanolic extract of Ephedra ciliata promotes wound healing and arrests inflammatory cascade in vivo through downregulation of TNF-α. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-08 Hafiza Sidra Yaseen,Muhammad Asif,Malik Saadullah,Mahrukh,Sajid Asghar,Muhammad Usman Shams,Rizwan Rashid Bazmi,Mohammad Saleem,Hafiz Muhammad Yousaf,Maria Yaseen
Chronic wounds may lead to the development of various pathological conditions such as diabetic foot ulcers and pressure sores. The current study evaluated wound healing and anti-inflammatory potentials of methanolic extract of Ephedra ciliata using series of in vivo models. Methanolic extract of Ephedra ciliata was prepared by maceration (Ec.Me). Qualitative and quantitative (HPLC) phytochemical and
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APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-07 A L Cross,J Hawkes,H L Wright,R J Moots,S W Edwards
Neutrophils are key players in the pathophysiological process underlying inflammatory conditions not only by release of tissue-damaging cytotoxic enzymes, reactive oxygen species (ROS) but also by secretion of important immunomodulatory chemokines and cytokines. Here, we report the effects of the novel agent APPA, undergoing formal clinical development for treatment of osteoarthritis, and its constituent
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Lapatinib inhibits doxorubicin induced migration of HER2-positive breast cancer cells. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-06 Naveen Chintalaramulu,Raja Vadivelu,Nam-Trung Nguyen,Ian Edwin Cock
Inflammatory breast cancer (IBC) is an uncommon and highly aggressive form of breast cancer. The disease is characterized by rapid progression with approximately 50% of IBC patients to have human epidermal growth factor receptor 2 (HER2) amplification. HER2-positive IBC is associated with unfavourable prognosis and increased risk of brain metastasis. Ironically, HER2-positive metastatic breast cancer
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Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-05 Nandhine Rajasekar,Ayyanar Sivanantham,Amrita Kar,Santanu Kar Mahapatra,Rajesh Ahirwar,Rajesh K Thimmulappa,Sudhakar Gandhi Paramasivam,Rajasekaran Subbiah
Pulmonary fibrosis (PF) is a chronic and irreversible scarring disease in the lung with limited treatment options. Therefore, it is critical to identify new therapeutic options. This study was undertaken to identify the effects of tannic acid (TA), a naturally occurring dietary polyphenol, in a mouse model of PF. Bleomycin (BLM) was intratracheally administered to induce PF. Administration of TA significantly
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Correction to: Appraisal of disease-modifying potential of amlodipine as an anti-arthritic agent: new indication for an old drug. Inflammopharmacology (IF 3.238) Pub Date : 2020-05-02 Sumera Qasim,Alamgeer,Saima Kalsoom,Muhammad Shahzad,Hafiz Muhammad Irfan,Muhammad Shoaib Zafar,Ishfaq Ali Bukhari,Fahim Vohra,Sibtain Afzal
Unfortunately, the 4th author name was incorrectly published in the original publication.
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Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-кB inflammatory signalling. Inflammopharmacology (IF 3.238) Pub Date : 2020-04-30 Jia-Huan Sun,Hong-Xia Yang,Ting-Ting Yao,Yuan Li,Lin Ruan,Geng-Rui Xu,Chuang Zhang,Guo-Xin Guo,Ai-Ying Li
Gentianella acuta (G. acuta), as a folk medicine, was used to treat heart disease by the Ewenki people in Inner Mongolia. However, the effect of G. acuta on acute myocardial infarction (AMI) is not clear. To explore the mechanisms of G. acuta on isoproterenol (ISO)-induced AMI, rats were administered G. acuta for 28 days, then injected intraperitoneally with ISO (85 mg/kg) on days 29 and 30. An electrocardiogram