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Impact of plasma Epstein–Barr virus DNA in posttreatment nasopharyngeal carcinoma patients after SARS-CoV-2 infection Infect. Agents Cancer (IF 3.7) Pub Date : 2024-03-14 Cheng Lin, Meifang Li, Yingying Lin, Yu Zhang, Hanchuan Xu, Bijuan Chen, Xia Yan, Yun Xu
Nasopharyngeal carcinoma (NPC) is prevalent in southern China. EBV DNA is the most useful biomarker in NPC. However, the value of EBV DNA in posttreatment NPC patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. Sixty-four eligible NPC patients were enrolled between December 2022 and February 2023. Patients who met the following criteria were included:
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Nelfinavir inhibition of Kaposi’s sarcoma-associated herpesvirus protein expression and capsid assembly Infect. Agents Cancer (IF 3.7) Pub Date : 2024-03-04 Maggie Li, Barbara J. Smith, Jaeyeun Lee, Jennifer Petr, Nicole M. Anders, Robyn Wiseman, Michelle A. Rudek, Richard F. Ambinder, Prashant J. Desai
Antiviral therapies that target herpesviruses are clinically important. Nelfinavir is a protease inhibitor that targets the human immunodeficiency virus (HIV) aspartyl protease. Previous studies demonstrated that this drug could also inhibit Kaposi’s sarcoma-associated herpesvirus (KSHV) production. Our laboratory demonstrated nelfinavir can effectively inhibit herpes simplex virus type 1 (HSV-1) replication
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Cox proportional hazard-model application: time to cervical cancer screening among women living with HIV in South Africa Infect. Agents Cancer (IF 3.7) Pub Date : 2024-03-02 Marcus Hollington
There is an increased risk of cervical cancer among women living with HIV. While studies have long examined the association between cervical cancer among women with HIV, no study has examined the time taken for women with HIV to undergo cervical cancer screening as well as the hazard thereof in South Africa. The study used cross-sectional data from the 2016 South Africa Demographic and Health Survey
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The global burden of cervical cancer requiring surgery: database estimates Infect. Agents Cancer (IF 3.7) Pub Date : 2024-02-26 Emma R Allanson, Syed Nabeel Zafar, Chidinma P Anakwenze, Kathleen M Schmeler, Edward L Trimble, Surbhi Grover
Scaling up surgical services for cervical cancer in low and middle income countries requires quantification of the need for those services. The aim of this study was to estimate the global burden of cervical cancer for which access to surgery is required. This was a retrospective analysis of publicly available data. Cervical cancer incidence was extracted for each country from the World Health Organization
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Trends in gynaecologic cancer mortality and the impact of the COVID-19 pandemic in the United States Infect. Agents Cancer (IF 3.7) Pub Date : 2024-02-20 Yuyan Xi, Yuxin Guo, Sikai Qiu, Fan Lv, Yujiao Deng, Jingyi Xie, Zixuan Xing, Yajing Bo, Chenyu Chang, Fan Zhang, Fanpu Ji, Mu Li
Our aim was to assess the trend in gynaecologic cancer (GC) mortality in the period from 2010 to 2022 in the United States, with focus on the impact of the pandemic on increased deaths. GC mortality data were extracted from the Center for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) platform. We analysed mortality trends and evaluated observed vs.
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The causality between CD8+NKT cells and CD16−CD56 on NK cells with hepatocellular carcinoma: a Mendelian randomization study Infect. Agents Cancer (IF 3.7) Pub Date : 2024-01-20 Zhengmei Lu, Xiaowei Chai, Yong Pan, Shibo Li
Hepatocellular carcinoma (HCC), which is featured with high morbidity and mortality worldwide, is a primary malignant tumor of the liver. Recently, there is a wealth of supporting evidence revealing that NK cell-related immune traits are strongly associated with the development of HCC, but the causality between them has not been proven. Two-sample Mendelian randomization (MR) study was performed to
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A systematic review of endometrial cancer clinical research in Africa Infect. Agents Cancer (IF 3.7) Pub Date : 2024-01-12 Chidinma P. Anakwenze, Agnes Ewongwo, Louisa Onyewadume, Ademola Oyekan, Chinelo Onwualu Chigbo, Luca Valle, Yimin Geng, Paul Olapade, Kenechukwu Okwunze, Nwamaka Lasebikan, Anuja Jhingran, Onyinye D. Balogun, Atara Ntekim
Women in Africa are experiencing a rising burden of endometrial cancer. Research and investment to improve treatment and outcomes are critically needed. We systematically reviewed and characterized endometrial cancer-related research within a clinically relevant context to help organize and assess existing endometrial cancer research in Africa. According to PRISMA guidelines, we searched online databases
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The prognostic role of PD-L1 expression and the presence of polyomavirus in Merkel cell carcinoma cases Infect. Agents Cancer (IF 3.7) Pub Date : 2024-01-04 Stella Meireles Siqueira, Gabriella Campos-do-Carmo, Paulo Ricardo Garcia da Silva, Isabele Ávila Small, Andreia Cristina De Melo
Merkel cell carcinoma (MCC) comprises a rare malignant primary skin tumor presenting neuroendocrine differentiation. Recently, agents blocking the programmed cell death protein 1 and programmed cell death protein ligand 1 pathway (PD-1/PD-L1) have demonstrated objective and durable tumor regressions in patients presenting advanced MCC. This study aimed to describe the sociodemographic, clinical, and
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Willingness to accept human papilloma virus vaccination and its associated factors among parents with eligible daughters in Addis Zemen town, Northwest Ethiopia Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-21 Mulugeta Wassie, Alebachew Ferede Zegeye, Wondesen Worku, Tiruye Sisay, Tsadik Eyob, Daniel Ayelegne Gebeyehu
Cervical cancer is one of the most common cancers in women. Evidences show that, routine immunization of girls at age 14 year and immunization of girls at age 9 year through a 5 years extended interval between doses are the most efficient to control the disease. Despite this, there is very little information on parents’ willingness to accept the human papilloma virus vaccine. Therefore, assessing willingness
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Correction: Do women with high-risk HPV E6/E7 mRNA test positivity and NILM cytology need colposcopy? Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-11 Ying Liu, Xiu Jin, Yingying Gong, Yingying Ma, Beibei Du, Linqing Yang, Yunfei Wang, Weipei Zhu
Infectious Agents and Cancer (2023) 18:54 https://doi.org/10.1186/s13027-023-00531-w After publication of this article [1], the authors reported that in this article all authors were assigned to affiliations 1 and 2, but it should be as follows: Ying Liu: 1 and 2; Xiu Jin, Yingying Gong, Yingying Ma, Beibei Du, Linqing Yang and Yunfei Wang: 2; Weipei Zhu: 1. The original article [1] has been corrected
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Polygenic risk scores for cervical HPV infection, neoplasia and cancer show potential for personalised screening: comparison of two methods Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-07 Anna Tisler, Anneli Uusküla, Sven Erik Ojavee, Kristi Läll, Triin Laisk
The era of precision medicine requires the achievement of accurate risk assessment. Polygenic risk scores (PRSs) have strong potential for increasing the benefits of nationwide cancer screening programs. The current pool of evidence on the role of a PRS as a risk stratification model in actual practice and implementation is limited. To better understand the impact of possible method-induced variance
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Post-conization surveillance in an organized cervical screening program with more than 23,000 years of follow-up Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-06 Avalon Sundqvist, Johanna Nicklasson, Pernilla Olausson, Christer Borgfeldt
Cervical cancer is preventable through screening and vaccination against high-risk human papillomavirus (hr-HPV). For a screening program to be successful it is vital that the clinical management and follow-up regime of patients with abnormal screening results is well developed and that the attendance rate for follow-up is high. The aim of the study was to analyze how effective conization with recommended
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Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-06 Dian Jin, Jing Le, Qianqian Yang, Qianqian Cai, Hui Dai, Liufei Luo, Jiaqi Tong, Wenxiu Shu
Previous studies achieved low microbial detection rates in lymphoma patients with interstitial pneumonia (IP) after chemotherapy. However, the metagenomic next-generation sequencing (mNGS) is a comprehensive approach that is expected to improve the pathogen identification rate. Thus far, reports on the use of mNGS in lymphoma patients with chemotherapy-related IP remain scarce. In this study, we summarized
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Clinical characteristics and outcomes of newly diagnosed patients with human immunodeficiency virus-associated Burkitt lymphoma: the Central and Western China AIDS lymphoma league 002 study (CALL-002 study) Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-05 Jinrong Zhao, Haiyan Min, Yunhong Huang, Yaokai Chen, Min Wang, Lirong Xiao, Guo Wei, Yan Wu, Yao Liu, Wei Zhang
Despite the introduction of combined antiretroviral therapy, the clinical outcomes of HIV-associated Burkitt lymphoma (BL) remain poor. To evaluate the clinical characteristics, prognostic factors, and outcomes of HIV-associated BL, we conducted a retrospective analysis of patients from multiple centers in China. The study included 41 patients from 8 medical centers. Among the included population,
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HPV18 L1 and long control region sequences variation and E6/E7 differential expression in nasopharyngeal and cervical cancers: a comparative study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-12-01 Sheila Santa, Charles A. Brown, Patrick K. Akakpo, Lawrence Edusei, Osbourne Quaye, Emmanuel A. Tagoe
The role of high-risk human papillomaviruses (hr-HPVs) in cervical cancer (CC) pathogenesis has long been established. Knowledge about the involvement of hr-HPVs in the etiology of nasopharyngeal cancers (NPC) was not well appreciated until the early 2000s when a clear link began to emerge. However, it is not clear whether HPV oncogenesis in the different epithelial cancers is associated with L1 gene
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Performance of DNA methylation analysis in the detection of high-grade cervical intraepithelial neoplasia or worse (CIN3+): a cross-sectional study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-29 Yuxiang Liu, Yan Chen, Jing Xiong, Peng Zhu, Yuhang An, Shu Li, Puxiang Chen, Qing Li
It is commonly accepted that host genes show high methylation in cervical intraepithelial neoplasia 3 (CIN3) or worse (CIN3+). However, study quality varies, as does the clinical performance of markers in different populations. We aimed to validate candidate gene DNA methylation with standardized testing methods in the same batch of samples. We first compared the performance of 16 DNA methylation markers
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Association between co-infection with Chlamydia trachomatis or Mycoplasma genitalium and cervical lesions in HPV-positive population in Hunan, China: a cross-sectional study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-29 Mengjie Jiang, Hui Ding, Ling He, Danning Xu, Ping Jiang, Haoneng Tang, Qian Wang, Xuemei Wang, Lingli Tang
The aim of this study was to determine the prevalence of Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) among HPV-positive women undergoing colposcopy at the Second Xiangya Hospital of Central South University, Hunan, China. Additionally, we aimed to assess the impact of C. trachomatis or M. genitalium co-infection with HPV on the severity of cervical lesions. We collected HPV data, cervical
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Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-28 Meixuan Wan, Xinxin Yang, Lin He, Hongxue Meng
Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing laryngeal cancer, the 5-year survival rate is disappointing. The gradual increase in the incidence of second primary tumors (SPTs) plays a crucial role in determining survival outcomes during long-term follow-up, and the esophagus was the most common site
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Findings from a Malaysian multicentre study on oropharyngeal squamous cell carcinoma Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-28 Hans Prakash Sathasivam, Sangeetha Passu Davan, Szu May Chua, Rahmuna Fazlina Rohaizat, Rohaizam Japar, Zahirrudin Zakaria, Abd Razak Ahmad, Hasmah Hashim, Shashi Gopalan Marimuthu, Yew Toong Liew, Doh Jeing Yong, Pappathy Vairavan, Avatar Singh Mohan Singh, Benjamin Hong Beng Goh, Zulkifli Yusof, Khairul Azlan Shahril Abu Dahari, Ali Haron, Masaany Mansor, Mohd Zambri Ibrahim, Shiraz Qamil Muhammad
In addition to the conventional aetiologic agents of oropharyngeal squamous cell carcinoma (OPSCC) such as tobacco usage, alcohol consumption and betel quid usage, it has been established that a proportion of OPSCC are driven by persistent oncogenic human papillomavirus (HPV) infections. Currently, there is a lack of data on the burden of HPV- associated OPSCC in Asian countries including Malaysia
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IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-13 Xiu Chen, Yu Zhang, Pingping Zhang, Mengzhu Wei, Tian Tian, Yanling Guan, Chenchen Han, Wei Wei, Yang Ma
Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive. Herein, we present evidence highlighting the influence exerted by insulin-like growth factor-binding protein 2 (IGFBP2) as a potent oncogene driving the malignant phenotype. Our investigation
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The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-10 Qiong Chen, Wanglei Qu, Yu Zhao, Li Shu, Yi Wang, Xiangnan Chen
The persistence of HPV infection is a significant etiological factor in the development of cervical cancer. The present study investigated the prevalence and genotype distribution of human papillomavirus (HPV) in a cohort of 164,137 unvaccinated women from Wenzhou, aiming to provide guidance for clinics in the cervical cancer screening and HPV vaccination strategies. The present retrospective study
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Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-08 Luisa Galati, Purnima Gupta, Antonio Tufaro, Mariarosaria Marinaro, Concetta Saponaro, David Israel Escobar Marcillo, Donato Loisi, Rajdip Sen, Alexis Robitaille, Rosario N. Brancaccio, Cyrille Cuenin, Sandrine McKay-Chopin, Angelo Virgilio Paradiso, Václav Liška, Pavel Souček, Francesco Alfredo Zito, David J. Hughes, Massimo Tommasino, Tarik Gheit
Although the role of viral agents, such as human papillomavirus (e.g. HPV16, HPV18) in colorectal cancer (CRC) has been previously investigated, results remain inconclusive. To further evaluate the involvement of oncogenic HPV types in CRC, 40 frozen neoplastic and 40 adjacent colonic tissues collected from Italian patients were analyzed by Luminex-based assays that detect a broad spectrum of HPV types
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Association of naturally acquired type-specific HPV antibodies and subsequent HPV re-detection: systematic review and meta-analysis Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-08 Kana Yokoji, Katia Giguère, Talía Malagón, Minttu M. Rönn, Philippe Mayaud, Helen Kelly, Sinead Delany-Moretlwe, Mélanie Drolet, Marc Brisson, Marie-Claude Boily, Mathieu Maheu-Giroux
Understanding the role of naturally acquired (i.e., infection-induced) human papillomavirus (HPV) antibodies against reinfection is important given the high incidence of this sexually transmitted infection. However, the protective effect of naturally acquired antibodies in terms of the level of protection, duration, and differential effect by sex remains incompletely understood. We conducted a systematic
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Engineered small extracellular vesicles as a novel platform to suppress human oncovirus-associated cancers Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-01 Iman Owliaee, Mehran khaledian, Armin Khaghani Boroujeni, Ali Shojaeian
Cancer, as a complex, heterogeneous disease, is currently affecting millions of people worldwide. Even if the most common traditional treatments, namely, chemotherapy (CTx) and radiotherapy (RTx), have been so far effective in some conditions, there is still a dire need for novel, innovative approaches to treat types of cancer. In this context, oncoviruses are responsible for 12% of all malignancies
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Epidemiology and survival outcomes of HIV-associated cervical cancer in Nigeria Infect. Agents Cancer (IF 3.7) Pub Date : 2023-11-01 Jonah Musa, Masha Kocherginsky, Francis A. Magaji, Ali J. Maryam, Joyce Asufi, Danjuma Nenrot, Kirsten Burdett, Neelima Katam, Elizabeth N. Christian, Nisha Palanisamy, Olukemi Odukoya, Olugbenga A. Silas, Fatimah Abdulkareem, Philip Akpa, Kabir Badmos, Godwin E. Imade, Alani S. Akanmu, Demirkan B. Gursel, Yinan Zheng, Brian T. Joyce, Chad J. Achenbach, Atiene S. Sagay, Rose Anorlu, Jian-Jun Wei, Folasade
Invasive cervical cancer (ICC) is an HIV-associated cancer that is preventable and precancerous stages including early ICC stages could be detected through screening offering opportunities for treatment and cure. The high incidence in women living with HIV and late presentation often at advanced stages of ICC with limited treatment facilities often result in early mortality. We sought to compare the
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Distribution patterns of human papillomavirus genotypes among women in Guangzhou, China Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-31 Shu Li, Kelan Zhang, Liu Yang, Jia Wu, Neha Bhargava, Yinghua Li, Fei Gao
Cervical cancer is associated with high‐risk human papillomavirus (HR-HPV) infection in the world. We aimed to evaluate the status of HPV infection among women in Guangzhou, China. The study recruited 28,643 female patients from the Guangzhou Women and Children’s Medical Center for HPV genotype testing between 2019 and 2021. 5668 patients were infected with HPV, resulting in an overall infection prevalence
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Can prophylactic HPV vaccination reduce the recurrence of cervical lesions after surgery? Review and prospect Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-29 Ling Han, Bingyi Zhang
Women with HSIL typically undergo conization/LEEP to remove cervical lesions, but the risk of HSIL lesions returning after surgical treatment remains higher than in the general population. HPV vaccination is essential to prevent cervical cancer. However, the effect of prophylactic HPV vaccination on reducing the risk of recurrent cervical lesions after surgical treatment remains unclear. This review
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Characterizing HIV status documentation among cancer patients at regional cancer centers in Malawi, Zimbabwe, and South Africa Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-26 Michalina A. Montaño, Takudzwa Mtisi, Ntokozo Ndlovu, Margaret Borok, Agatha Bula, Maureen Joffe, Rachel Bender Ignacio, Maganizo B. Chagomerana
In East and Southern Africa, people with HIV (PWH) experience worse cancer-related outcomes and are at higher risk of developing certain cancers. Siloed care delivery pathways pose a substantial barrier to co-management of HIV and cancer care delivery. We conducted cross-sectional studies of adult cancer patients at public radiotherapy and oncology units in Malawi (Kamuzu Central Hospital), Zimbabwe
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Impact of NLRP3 gene polymorphisms (rs10754558 and rs10733113) on HPV infection and cervical cancer in southern Chinese population Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-26 Qingchun Lu, Xiaoxia Lao, Jinghua Gan, Ping Du, Yingpei Zhou, Wenzheng Nong, Zhige Yang
Mutations in the NLRP3gene have previously been linked to certain forms of cancer, but there have not been any specific studies examining the association between NLRP3 polymorphisms and cervical cancer (CC). This study was therefore designed to investigate the effect of NLRP3 gene polymorphisms on HPV infection and cervical cancer in southern Chinese population. Multiplex PCR and next-generation sequencing
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Oral-genital HPV infection transmission, concordance of HPV genotypes and genital lesions among spouses/ partners of patients diagnosed with HPV-related head and neck squamous cell carcinoma (HNSCC): a scoping review Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-19 Nadia Kalinganire, Annette Uwineza, Lynnette Kyokunda, Cecily Banura
There is an increase in number of Human Papillomavirus related head and neck squamous cell carcinoma (HPV-related HNSCC) High risk HPV(HR-HPV) types can be cleared by an infected person, however, some can persist and develop HN cancer. There is a broad knowledge gap regarding HPV and related cancers. The aim of this review is to assess existing published knowledge on oral-genital HPV transmission,
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Exploring hematic crasis variations in cancer patients following SARS-CoV-2 vaccination: a real-practice study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-17 Liliana Montella, Carmela Dell’Aversana, Daniela Pacella, Simona Troise, Paola Russo, Valentina Cacciapuoti, Alessandro Ottaiano, Luigi Di Marino, Paola Coppola, Carmela Liguori, Massimiliano Berretta, Salvatore Maddaluno, Lucia Altucci, Gaetano Facchini
SARS-CoV-2 vaccination is strongly recommended, particularly for fragile patients such as those undergoing active oncological treatments. It is crucial to conduct post-marketing surveillance in this patient population. In our study, we conducted a retrospective analysis of real-world data, including 136 patients who received SARS-CoV-2 vaccines and were undergoing anticancer treatments between March
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Validation in Zambia of a cervical screening strategy including HPV genotyping and artificial intelligence (AI)-based automated visual evaluation Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-16 Groesbeck P. Parham, Didem Egemen, Brian Befano, Mulindi H. Mwanahamuntu, Ana Cecilia Rodriguez, Sameer Antani, Samson Chisele, Mukatimui Kalima Munalula, Friday Kaunga, Francis Musonda, Evans Malyangu, Aaron Lunda Shibemba, Silvia de Sanjose, Mark Schiffman, Vikrant V. Sahasrabuddhe
WHO has recommended HPV testing for cervical screening where it is practical and affordable. If used, it is important to both clarify and implement the clinical management of positive results. We estimated the performance in Lusaka, Zambia of a novel screening/triage approach combining HPV typing with visual assessment assisted by a deep-learning approach called automated visual evaluation (AVE). In
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The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-12 Marwan K. Saeed, B. A. Al-Ofairi, Mohammed A. Hassan, M. A. Al-Jahrani, Ahmed M. Abdulkareem
Helicobacter pylori (H. pylori) is a carcinogenic bacterium, it is the greatest risk factor for gastric cancer (GC), according to these evidences, there may be a certain association between chronic H. pylori infections and serum levels of tumor markers. This study was conducted to determine serum levels of some tumor markers, namely carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and cancer
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Acceptance of human papillomavirus vaccination and parents’ willingness to vaccinate their adolescents in Ethiopia: a systematic review and meta-analysis Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-11 Awoke Derbie, Daniel Mekonnen, Eyaya Misgan, Melanie Maier, Yimtubezinash Woldeamanuel, Tamrat Abebe
Despite the global vaccination campaign to prevent HPV-related morbidity, HPV vaccination uptake remains unacceptably low in the developing world, like Ethiopia. For strong interventional measures, compiled data in the field is required which is otherwise missed in the Ethiopian context. Therefore, this systematic review aimed to provide an estimate of the HPV vaccination uptake, mothers‘ willingness
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Imaging of human papilloma virus (HPV) related oropharynx tumour: what we know to date Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-09 Eleonora Bicci, Leonardo Calamandrei, Francesco Mungai, Vincenza Granata, Roberta Fusco, Federica De Muzio, Luigi Bonasera, Vittorio Miele
The tumours of head and neck district are around 3% of all malignancies and squamous cell carcinoma is the most frequent histotype, with rapid increase during the last two decades because of the increment of the infection due to human papilloma virus (HPV). Even if the gold standard for the diagnosis is histological examination, including the detection of viral DNA and transcription products, imaging
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Risk of cervical intraepithelial neoplasia grade 3 or more diagnoses for human papillomavirus16/18-positive women by cytology and co-infection status Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-09 Mengyin Ao, Xiaoxi Yao, Danxi Zheng, Xuesai Gu, Mingrong Xi
Human papillomavirus (HPV) 16 and 18 cause approximately 70% of cervical cancer cases. The aim of this study was to evaluate whether co-infected with other HPV genotypes will affect the risk of cervical carcinogenesis in HPV16/18 positive-women. In this cross-sectional study, cervical cytology and histological classifications from women who tested positive for HPV 16/18 and underwent colposcopy within
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Correction: Cancer signs and risk factors awareness in Addis Ababa, Ethiopia: a population-based survey Infect. Agents Cancer (IF 3.7) Pub Date : 2023-10-03 Zinaye Tekeste, Nega Berhe, Mahlet Arage, Abraham Degarege, Yohannes Adama Melaku
Correction to: Infectious Agents and Cancer (2023) 18:1. https://doi.org/10.1186/s13027-022-00477-5 Following publication of the original article [1], the authors identified an error in the authorship: due to miscommunication, the last author (Amy Reynolds) did not have the opportunity to appropriately contribute to the manuscript, which violates the ICMJE criteria for authorship and her name therefore
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Epstein–Barr virus (EBV) antibody changes over time in a general population cohort in rural Uganda, 1992–2008 Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-29 Katherine R. Sabourin, Joseph Mugisha, Gershim Asiki, Angela Nalwoga, Nazzarena Labo, Wendell Miley, Rachel Beyer, Rosemary Rochford, Thomas W. Johnston, Robert Newton, Denise Whitby
Epstein–Barr virus (EBV) infection is ubiquitous and in sub-Saharan Africa, occurs early in life. In a population-based rural African cohort, we leveraged historical samples from the General Population Cohort (GPC) in Uganda to examine the epidemiology of infection with EBV over time, in the era of HIV. We used 9024 serum samples collected from the GPC in 1992, 2000, 2008, from 7576 participants across
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Do women with high-risk HPV E6/E7 mRNA test positivity and NILM cytology need colposcopy? Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-29 Ying Liu, Xiu Jin, Yingying Gong, Yingying Ma, Beibei Du, Linqing Yang, Yunfei Wang, Weipei Zhu
This study aimed to assess the value of an HPV E6/E7 mRNA assay and HPV 16 18/45 genotype assay combined with age stratification for triaging women negative for intraepithelial lesions or malignancy (NILM) cytology. From January 2017 to December 2021, a total of 162,309 eligible women underwent cervical cancer screening at the Affiliated Hospital of Jining Medical University, China. Excluding those
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Sociodemographic characteristics, attitudes, and knowledge associated with previous screening for cervical cancer among women in western Jamaica Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-23 Pauline E. Jolly, Anna Junkins, Maung Aung
About 90% of new cervical cancer cases and deaths worldwide in 2020 occurred in low- and middle-income countries. This can be attributed to the low rates of cervical cancer screening in these countries. This study was conducted to identify factors associated with lack of cervical cancer screening among women in western Jamaica with the aim to increase screening and decrease cervical cancer risk. This
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Prevalence of blood stream infections and associated factors among febrile neutropenic cancer patients on chemotherapy at Ocean Road Cancer Institute, Tanzania Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-20 Lambert C. Safari, Doreen Mloka, Omary Minzi, Nazima J. Dharsee, Rabson Reuben
Febrile Neutropenia (FN) caused by bacteria in cancer patients is associated with poor prognosis. The aim of this study was to determine the prevalence of FN and associated factors among cancer patients on chemotherapy at Ocean Road Cancer Institute (ORCI), Tanzania. A cross-sectional study was conducted from June to September 2019. Study participants were conveniently recruited. A desk review of participants
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Human parvovirus B19 infection in malignant and benign tissue specimens of different head and neck anatomical subsites Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-14 Haniyeh Abuei, Sepide Namdari, Tahereh Pakdel, Fatemeh Pakdel, Azadeh Andishe-Tadbir, Abbas Behzad-Behbahani, Mohammad J. Ashraf, Parnian Alavi, Ali Farhadi
The role of human parvovirus B19 (B19V) infection in malignant and benign lesions such as head and neck squamous cell carcinomas (HNSCCs) and oral mucocele lesions has not been established. Herein, we examined, for the first time, the presence of B19V in HNSCCs from Iranian subjects. One hundred and eight HNSCC specimens were analyzed for the presence of B19V using nested polymerase chain reaction
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COVID-19 vaccination is associated with enhanced efficacy of anti-PD-(L)1 immunotherapy in advanced NSCLC patients: a real-world study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-07 Yunfei Qian, Zhuxian Zhu, Yin-Yuan Mo, Ziqiang Zhang
Coronavirus disease 2019 (COVID-19) vaccine has played a major role in ending the pandemic. However, little is known about the influence of COVID-19 vaccine on the efficacy of immunotherapy in patients with non-small cell lung cancer (NSCLC). The goal of this study is to explore whether COVID-19 vaccine impacts the efficacy of immune checkpoint inhibitors (ICIs) in NSCLC patients. We retrospectively
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An overview of mouse models of hepatocellular carcinoma Infect. Agents Cancer (IF 3.7) Pub Date : 2023-09-05 Hua-chuan Zheng, Hang Xue, Wen-Jing Yun
Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective treatments for HCC are limited. The lack of suitable preclinical models may contribute to a major failure of drug development for HCC. Here, we overview several well-established mouse models of HCC, including genetically engineered mice, chemically-induced models
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Evaluation of enterotoxigenic Bacteroides fragilis correlation with the expression of cellular signaling pathway genes in Iranian patients with colorectal cancer Infect. Agents Cancer (IF 3.7) Pub Date : 2023-08-29 Leila Dadgar-Zankbar, Aref Shariati, Narjess Bostanghadiri, Zahra Elahi, Shiva Mirkalantari, Shabnam Razavi, Fatemeh Kamali, Davood Darban-Sarokhalil
Colorectal cancer (CRC) is one of the most common cancers all over the world, and dysbiosis in the gut microbiota may play a role in colorectal carcinogenesis. Bacteroides fragilis can lead to tumorigenesis by changing signaling pathways, including the WNT/β-catenin pathway. Therefore, in the present study, we investigated the correlation between the enterotoxigenic B. fragilis amount and the expression
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Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma Infect. Agents Cancer (IF 3.7) Pub Date : 2023-08-28 Amal Alotaibi, Veerendra P. Gadekar, Pranav Swaroop Gundla, Sumana Mandarthi, Nidhi Jayendra, Asna Tungekar, B. V. Lavanya, Ashok Kumar Bhagavath, Mary Anne Wong Cordero, Janne Pitkaniemi, Shaik Kalimulla Niazi, Raghavendra Upadhya, Asmatanzeem Bepari, Prashantha Hebbar
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. Despite numerous transcriptomics studies to understand its molecular basis, the impact of population-specific differences on this disease remains unexplored. This study aimed to investigate the population-specific differences in gene expression patterns among ESCC samples obtained
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Antiproliferative effects of mesenchymal stem cells carrying Newcastle disease virus and Lactobacillus Casei extract on CT26 Cell line: synergistic effects in cancer therapy Infect. Agents Cancer (IF 3.7) Pub Date : 2023-07-31 Akbar Ghorbani Alvanegh, Majid Mirzaei Nodooshan, Ruhollah Dorostkar, Reza Ranjbar, Bahman Jalali Kondori, Alireza Shahriary, Karim Parastouei, Soheil Vazifedust, Elmira Afrasiab, Hadi Esmaeili Gouvarchinghaleh
Colorectal Cancer (CRC) is a frequent malignancy with a high mortality rate. Specific inherited and environmental influences can affect CRC. Oncolytic viruses and bacteria in treating CRC are one of the innovative therapeutic options. This study aims to determine whether mesenchymal stem cells (MSCs) infected with the Newcastle Disease Virus (NDV) in combination with Lactobacillus casei extract (L
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Cancerogenic parasites in veterinary medicine: a narrative literature review Infect. Agents Cancer (IF 3.7) Pub Date : 2023-07-26 Niccolò Fonti, Francesca Parisi, Francesca Mancianti, Giulia Freer, Alessandro Poli
Parasite infection is one of the many environmental factors that can significantly contribute to carcinogenesis and is already known to be associated with a variety of malignancies in both human and veterinary medicine. However, the actual number of cancerogenic parasites and their relationship to tumor development is far from being fully understood, especially in veterinary medicine. Thus, the aim
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Frequency of viral infections in adolescent and adult in-patient Ethiopians with acute leukemia at presentation to a tertiary care teaching hospital: a cross-sectional study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-07-12 Jemal Alemu, Balako Gumi, Aster Tsegaye, Abdulaziz Abubeker, Fisihatsion Tadesse, Abel Shewaye, Ziyada Rahimeto, Adane Mihret, Andargachew Mulu, Amha Gebremedhin, Rawleigh Howe
Leukemic patients are prone to infectious agents such as viruses due to dysregulated immune system resulting from infiltration of the bone marrow by malignant cells, chronic stimulation, reactivation of some viruses and viral pathogenicity as well as rarely from acquisition of a new infections leading to severe complications. However, the prevalence of these infections has not been systematically documented
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p16INK4a and pRb expression in laryngeal squamous cell carcinoma with and without infection by EBV or different genotypes of HPV: a retrospective study Infect. Agents Cancer (IF 3.7) Pub Date : 2023-07-11 Jose Manuel Vazquez-Guillen, Gerardo C. Palacios-Saucedo, Alondra Yamileth Alanis-Valdez, Andrea Huerta-Escobedo, Angel Zavala-Pompa, Lydia Guadalupe Rivera-Morales, Ana Carolina Martinez-Torres, Vianey Gonzalez-Villasana, Julio Cesar Serna-Hernandez, Silvia Judith Hernandez-Martinez, Edmundo Erbey Castelan-Maldonado, Martha Socorro Montalvo-Bañuelos, Cesar Alejandro Alonso-Tellez, Ethel Corinthia
Laryngeal squamous cell carcinoma (LSCC) represents one of the principal tumors of the head and neck. Human papillomavirus (HPV) and Epstein–Barr virus (EBV) are considered risk factors for the development and the clinical prognosis of LSCC. High levels of p16INK4a are suggested as a surrogate marker of HPV or EBV infection in some head and neck tumors but in LSCC is still controversial. Furthermore
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Association of dietary intake and cervical cancer: a prevention strategy Infect. Agents Cancer (IF 3.7) Pub Date : 2023-07-06 Elham Nazari, Malihe Hasanzadeh, Reza Rezvani, Marzieh Rejali, Mohaddeseh Badpeyma, Zeinab Delaram, Leila Mousavi-Seresht, Mahdieh Akbari, Majid Khazaei, Gordon A. Ferns, Amir Avan
Cervical cancer is one of lethal cancers in women. As a global concern, identifying important factors of cancer is a useful strategy for prevention. Due to the role of diet/nutrition factors for cancer, the purpose of our study was to determine the impact of 150 nutrition/vitamin factors and 50 non-nutritional factor in cervical cancer and phase. Population samples of 2088 healthy subjects and patients
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A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification Infect. Agents Cancer (IF 3.7) Pub Date : 2023-07-01 Shenghao Li, Liyuan Hao, Xiaoyu Hu, Luya Li
Chronic hepatitis B virus (HBV) infection is the major etiology of hepatocellular carcinoma (HCC). However, the mechanism of hepatitis B-related hepatocellular carcinoma (HBV-related HCC) is still unclear. Therefore, understanding the pathogenesis and searching for drugs to treat HBV-related HCC was an effective strategy to treat this disease. Bioinformatics was used to predict the potential targets
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Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis Infect. Agents Cancer (IF 3.7) Pub Date : 2023-06-29 Francesca Parisi, Niccolò Fonti, Francesca Millanta, Giulia Freer, Mauro Pistello, Alessandro Poli
Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple agents have been implicated in various forms of neoplasia, with viruses as the most frequent. In recent years, investigation on viral mechanisms underlying tumoral transformation in cancer development and progression are in the spotlight, both in human and
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Prevalence of MMTV-like sequences in breast cancer samples in Romanian patients-there is a geographic difference compared to the Western world Infect. Agents Cancer (IF 3.7) Pub Date : 2023-06-20 Zsolt Fekete, Bristena Octavia Tertan, Lajos Raduly, Dan Tudor Eniu, Rares Buiga, Mihaela Galatar, Ioana Berindan-Neagoe
Breast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent cancer types. Mouse-mammary tumor virus (MMTV) is involved in breast cancer in mice and dogs and might play a role in the etiology of some breast cancers in humans, since an MMTV-like sequence was identified in 20–40% of breast cancer samples in Western Europe, USA,
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Comparison of Epstein–Barr virus and Kaposi’s sarcoma-associated herpesvirus viral load in peripheral blood mononuclear cells and oral fluids of HIV-negative individuals aged 3–89 years from Uganda Infect. Agents Cancer (IF 3.7) Pub Date : 2023-06-14 Angela Nalwoga, Vickie Marshall, Wendell Miley, Nazzarena Labo, Denise Whitby, Robert Newton, Rosemary Rochford
We previously found that age, sex and malaria were associated with KSHV in individuals from Uganda. In this study, we have evaluated these same factors in relation to EBV in the same specimens. Overall, 74% (oral fluids) and 46% (PBMCs) had detectable EBV. This was significantly higher than observed for KSHV (24% oral fluids and 11% PBMCs). Individuals with EBV in PBMCs were more likely to have KSHV
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Detection of Epstein–Barr virus infection in thymic epithelial tumors by nested PCR and Epstein–Barr-encoded RNA ISH Infect. Agents Cancer (IF 3.7) Pub Date : 2023-06-09 Li Zhao, Jian-Yong Ding, Yun-Lan Tao, Kun Zhu, Gang Chen
Epstein–Barr virus (EBV) is well known to be associated with a lot of tumors, including lymphoma, nasopharyngeal carcinoma, EBV-associated gastric carcinoma, and some other carcinomas with similar lymphoepithelioma-like features. However, the association between EBV and thymic epithelial tumors (TETs) is inconclusive as reports in this regard are not entirely consistent and the methods employed are
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Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series Infect. Agents Cancer (IF 3.7) Pub Date : 2023-06-02 Maria Balestrieri, Caterina Carnovale-Scalzo, Anna Rosa Garbuglia, Maria Vincenza Chiantore, Luisa Accardi, Paola Di Bonito
This report covers the case of 7 women affected by pathologies related to genital Herpesvirus and Papillomavirus. They were referred to the gynaecology outpatient clinic for colposcopic examination, and received pharmacological antiviral treatment. The patients presented clinical signs of genital Herpesvirus infections in the cervix and vulva. Cervical lesions and condylomatosis, which are characteristic
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Use of programmed cell death protein 1 (PD-1) inhibitor therapy in HIV-infected patients with advanced cancer: a single-center study from China Infect. Agents Cancer (IF 3.7) Pub Date : 2023-05-30 Luling Wu, Jie Su, Junyang Yang, Ling Gu, Renfang Zhang, Li Liu, Hongzhou Lu, Jun Chen
Anti-PD-1 antibodies have been approved for treating several cancer. However, data regarding the safety and efficacy of these agents in HIV-infected patients with cancer is lacking, because these patients are frequently omitted from clinical trials. The primary aim of our research is to assess the safety, activity, and long-term outcomes of PD-1 inhibitors in the treatment of HIV-infected patients
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Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center Infect. Agents Cancer (IF 3.7) Pub Date : 2023-05-27 Vincenza Granata, Roberta Fusco, Alberta Villanacci, Francesca Grassi, Roberta Grassi, Federica Di Stefano, Ada Petrone, Nicoletta Fusco, Stefania Ianniello
Objective: to evaluate the efficacy of US, both qualitatively and semi-quantitatively, in the selection of treatment for the Covid-19 patient, using patient triage as the gold standard. Methods: Patients admitted to the Covid-19 clinic to be treated with monoclonal antibodies (mAb) or retroviral treatment and undergoing lung ultrasound (US) were selected from the radiological data set between December
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High-risk human papillomavirus genotype distribution among women living with HIV; implication for cervical cancer prevention in a resource limited setting Infect. Agents Cancer (IF 3.7) Pub Date : 2023-05-26 Patrick Kafui Akakpo, Sebastian Ken-Amoah, Nancy Innocentia Ebu Enyan, Elizabeth Agyare, Emmanuel Salia, Ibrahim Baidoo, Leonard Derkyi-Kwarteng, Matthew Asare, George Adjei, Stephen Ayisi Addo, Dorcas Obiri-Yeboah
For women living with HIV (WLHIV), the burden of persistent HPV infection, cervical pre-cancerous lesions and cancer have been demonstrated to be higher than among HIV-negative women. As Ghana and other lower-middle-income countries (LMIC) work toward developing national cervical cancer programmes, it is essential that local scientific evidence be provided to guide policy decisions, especially for