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  • Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-28
    Virgil Schijns; Alberto Fernández‐Tejada; Žarko Barjaktarović; Ilias Bouzalas; Jens Brimnes; Sergey Chernysh; Sveinbjorn Gizurarson; Ihsan Gursel; Žiga Jakopin; Maria Lawrenz; Cristina Nativi; Stephane Paul; Gabriel Kristian Pedersen; Camillo Rosano; Ane Ruiz‐de‐Angulo; Bram Slütter; Aneesh Thakur; Dennis Christensen; Ed C. Lavelle

    Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non‐infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination can at least in principle be proposed as a therapeutic strategy. Understanding the nature of protective immunity is of vital importance, and the progress made in recent years in defining

    更新日期:2020-06-28
  • How intrinsic and extrinsic regulators of plasma cell survival might intersect for durable humoral immunity
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-26
    Marcus J. Robinson; Rosela H. Webster; David M. Tarlinton

    Plasma cells (PC) are key to protective immunity because they secrete antibodies. Surviving for periods ranging from days to decades in mammals, PC possess varying survival times that cannot be entirely stochastic or extrinsically set, as presumed half‐lives vary with antigenic specificity. Here, we review the signals that impart survival potential to PC. These include signals provided during formation

    更新日期:2020-06-27
  • The role of innate immunity in Alzheimer's disease
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-26
    Hannah E. Ennerfelt; John R. Lukens

    The amyloid hypothesis has dominated Alzheimer's disease (AD) research for almost 30 years. This hypothesis hinges on the predominant clinical role of the amyloid beta (Aβ) peptide in propagating neurofibrillary tangles (NFTs) and eventual cognitive impairment in AD. Recent research in the AD field has identified the brain‐resident macrophages, known as microglia, and their receptors as integral regulators

    更新日期:2020-06-26
  • Cross talk between intracellular pathogens and cell death.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-22
    Benjamin Demarco,Kaiwen W Chen,Petr Broz

    Infections with bacterial pathogens often results in the initiation of programmed cell death as part of the host innate immune defense, or as a bacterial virulence strategy. Induction of host cell death is controlled by an elaborate network of innate immune and cell death signaling pathways and manifests in different morphologically and functionally distinct forms of death, such as apoptosis, necroptosis

    更新日期:2020-06-22
  • Control of foreign Ag-specific Ab responses by Treg and Tfr.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    James B Wing,Ee Lyn Lim,Shimon Sakaguchi

    Regulatory T cells (Tregs) expressing the transcription factor Foxp3 play a critical role in the control of immune homeostasis including the regulation of humoral immunity. Recently, it has become clear that a specialized subset of Tregs, T‐follicular regulatory cells (Tfr), have a particular role in the control of T‐follicular helper (Tfh) cell‐driven germinal center (GC) responses. Following similar

    更新日期:2020-06-22
  • Lipids, inflammasomes, metabolism, and disease.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    Paras K Anand

    Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death, pyroptosis. Several members of the nod‐like receptor family assemble inflammasome in response to specific ligands. An exception to this is the NLRP3 inflammasome which is activated by structurally diverse entities. Recent

    更新日期:2020-06-22
  • Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    Valerie Harrington,Prajwal Gurung

    Leishmaniasis is a global health problem that affects more than 2 billion people worldwide. Recent advances in research have demonstrated critical roles for cytoplasmic sensors and inflammasomes during Leishmania spp. infection and pathogenesis. Specifically, several studies have focused on the role of nod‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome and inflammasome‐associated

    更新日期:2020-06-22
  • Nuclear innate sensors for nucleic acids in immunity and inflammation.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    Hongyu Lin,Xuetao Cao

    Innate sensors recognize pathogen‐associated molecular patterns (PAMPs) or damage‐associated molecular patterns (DAMPs) to initiate innate immune response by activating downstream signaling. These evolutionarily conserved innate sensors usually locate in the plasma membrane or cytoplasm. However, the nucleus‐localized innate sensors are recently found to detect pathogenic nucleic acids for initiating

    更新日期:2020-06-22
  • The NLRP1 and CARD8 inflammasomes.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-19
    Cornelius Y Taabazuing,Andrew R Griswold,Daniel A Bachovchin

    Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are related germline‐encoded pattern recognition receptors that form inflammasomes, but their activation mechanisms and biological purposes have not yet been fully established. Both NLRP1 and CARD8 undergo post‐translational autoproteolysis

    更新日期:2020-06-19
  • T cell help to B cells: Cognate and atypical interactions in peripheral and intestinal lymphoid tissues.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-18
    Adi Biram,Ziv Shulman

    Enduring immunity against harmful pathogens depends on the generation of immunological memory. Serum immunoglobulins are constantly secreted by long‐lived antibody‐producing cells, which provide extended protection from recurrent exposures. These cells originate mainly from germinal center structures, wherein B cells introduce mutations to their immunoglobulin genes followed by affinity‐based selection

    更新日期:2020-06-18
  • Influenza vaccination strategies targeting the hemagglutinin stem region.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-16
    Hidehiro Fukuyama,Ryo Shinnakasu,Tomohiro Kurosaki

    Influenza is one of the best examples of highly mutable viruses that are able to escape immune surveillance. Indeed, in response to influenza seasonal infection or vaccination, the majority of the induced antibodies are strain‐specific. Current vaccine against the seasonal strains with the strategy of surveillance‐prediction‐vaccine does not cover an unmet virus strain leading to pandemic. Recently

    更新日期:2020-06-16
  • Age-related factors that affect B cell responses to vaccination in mice and humans.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-02
    Daniela Frasca,Bonnie B Blomberg,Denisse Garcia,Spencer R Keilich,Laura Haynes

    Aging significantly changes the ability to respond to vaccinations and infections. In this review, we summarize published results on age‐related changes in response to infection with the influenza virus and on the factors known to increase influenza risk infection leading to organ failure and death. We also summarize how aging affects the response to the influenza vaccine with a special focus on B

    更新日期:2020-06-02
  • Factors in B cell competition and immunodominance.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-01
    Robert K Abbott,Shane Crotty

    The majority of all vaccines work by inducing protective antibody responses. The mechanisms by which the B cells responsible for producing protective antibodies are elicited to respond are not well understood. Interclonal B cell competition to complex antigens, particularly in germinal centers, has emerged as an important hurdle in designing effective vaccines. This review will focus on recent advances

    更新日期:2020-06-01
  • The geography of memory B cell reactivation in vaccine-induced immunity and in autoimmune disease relapses.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-30
    Rama Dhenni,Tri Giang Phan

    Memory B cells (Bmem) provide an active second layer of defense against re‐infection by pathogens that have bypassed the passive first layer provided by neutralizing antibodies. Here, we review recent progress in our understanding of Bmem heterogeneity in terms of their origin (germinal center‐dependent vs center‐independent), phenotype (canonical vs atypical vs age‐associated B cells), trafficking

    更新日期:2020-05-30
  • The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics".
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-30
    Mona O Mohsen,Gilles Augusto,Martin F Bachmann

    Vaccines need to be rationally designed in order be delivered to the immune system for maximizing induction of dynamic immune responses. Virus‐like particles (VLPs) are ideal platforms for such 3D vaccines, as they allow the display of complex and native antigens in a highly repetitive form on their surface and can easily reach lymphoid organs in intact form for optimal activation of B and T cells

    更新日期:2020-05-30
  • Signals 1, 2 and B cell fate or: Where, when and for how long?
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-29
    Jackson S Turner,Zachary L Benet,Irina L Grigorova

    Diverse B cell responses are important for generating antibody‐mediated protection against highly variable pathogens. While some antigens can trigger T‐independent B cell proliferation and short‐term antibody production, development of long‐term humoral immunity requires T‐dependent B cell responses. The “two‐signal” model of B cell activation has long been invoked to explain alternate B cell recruitment

    更新日期:2020-05-29
  • T follicular helper cells in germinal center B cell selection and lymphomagenesis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-15
    Michelle A Mintz,Jason G Cyster

    Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long-lived plasma cells. GCs are also the origin of malignancy, namely follicular lymphoma (FL), GC B cell-diffuse large B cell lymphoma (GCB-DLBCL), and Burkitt lymphoma (BL). GC B cell lymphomas maintain their GC transcriptional

    更新日期:2020-05-15
  • Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-23
    Federico Martinelli,Anna Perrone,Isabella Della Noce,Lorenzo Colombo,Stefano Lo Priore,Simone Romano

    The ongoing outbreak of the novel coronavirus (SARS-CoV-2) infection is creating serious challenges for health laboratories that seek to identify viral infections as early as possible, optimally at the earliest appearance of symptom. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where

    更新日期:2020-04-24
  • Immunometabolism: From basic mechanisms to translation.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-01
    Liza Makowski,Mehdi Chaib,Jeffrey C Rathmell

    Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were induced in obese adipose tissue and that these cytokines contributed to metabolic disease, it was clear that metabolism and the immunological state are inextricably linked. With a second research wave arising from studies in cancer metabolism to

    更新日期:2020-04-23
  • Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-01
    Azadeh Bahadoran,Lavanya Bezavada,Heather S Smallwood

    Recent studies support the notion that glycolysis and oxidative phosphorylation are rheostats in immune cells whose bioenergetics have functional outputs in terms of their biology. Specific intrinsic and extrinsic molecular factors function as molecular potentiometers to adjust and control glycolytic to respiratory power output. In many cases, these potentiometers are used by influenza viruses and

    更新日期:2020-04-23
  • Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-01
    Laura M Sipe,Mehdi Chaib,Ajeeth K Pingili,Joseph F Pierre,Liza Makowski

    Bile acids (BAs) are known facilitators of nutrient absorption but recent paradigm shifts now recognize BAs as signaling molecules regulating both innate and adaptive immunity. Bile acids are synthesized from cholesterol in the liver with subsequent microbial modification and fermentation adding complexity to pool composition. Bile acids act on several receptors such as Farnesoid X Receptor and the

    更新日期:2020-04-23
  • The role of B cell antigen presentation in the initiation of CD4+ T cell response.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-18
    Zhaolin Hua,Baidong Hou

    B cells have been known for their ability to present antigens to T cells for almost 40 years. However, the precise roles of B cell antigen presentation in various immune responses are not completely understood. The term "professional" antigen-presenting cells (APCs) was proposed to distinguish APCs that are required for initiating the immune responses from those use antigen presentation to enhance

    更新日期:2020-04-22
  • Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-03
    Nikki van Teijlingen Bakker,Edward J Pearce

    We have only recently started to appreciate the extent to which immune cell activation involves significant changes in cellular metabolism. We are now beginning to understand how commitment to specific metabolic pathways influences aspects of cellular biology that are the more usual focus of immunological studies, such as activation-induced changes in gene transcription, post-transcriptional regulation

    更新日期:2020-04-03
  • Adipose tissue macrophages: Unique polarization and bioenergetics in obesity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-01
    Heather L Caslin,Monica Bhanot,W Reid Bolus,Alyssa H Hasty

    Macrophages comprise a majority of the resident immune cells in adipose tissue (AT) and regulate both tissue homeostasis in the lean state and metabolic dysregulation in obesity. Since the AT environment rapidly changes based upon systemic energy status, AT macrophages (ATMs) must adapt phenotypically and metabolically. There is a distinct dichotomy in the polarization and bioenergetics of in vitro

    更新日期:2020-04-01
  • Chemical individuality in T cells: A Garrodian view of immunometabolism.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-31
    Peter J McGuire

    Metabolically quiescent T cells circulate throughout the body in search of antigen. Following engagement of their cognate receptors, T cells undergo metabolic reprogramming to support their activation, differentiation, and ultimately function. In the spirit of Sir Archibald Garrod, this metabolic reprogramming actually imparts a chemical individuality which confers advantage, while in others confers

    更新日期:2020-03-31
  • mTOR signaling at the crossroads of environmental signals and T-cell fate decisions.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-25
    Hongling Huang,Lingyun Long,Peipei Zhou,Nicole M Chapman,Hongbo Chi

    The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates signals from the environment to coordinate downstream signaling events and various cellular processes. T cells rely on mTOR activity for their development and to establish their homeostasis and functional fitness. Here, we review recent progress

    更新日期:2020-03-25
  • The role of metabolic checkpoint regulators in B cell survival and transformation.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-17
    Julia Jellusova

    In response to mitogenic stimulation, B cells activate different pro-anabolic signaling pathways such as c-Myc- and mTORC1-dependent networks to satisfy the energetic demands of biomass synthesis and proliferation. In order to preserve viability and function, cell growth cannot progress unchecked and must be adjusted according to the availability of nutrients. Nutrient-sensing proteins such as AMPK

    更新日期:2020-03-17
  • Complement and human T cell metabolism: Location, location, location.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-12
    Erin E West,Natalia Kunz,Claudia Kemper

    The complement system represents one of the evolutionary oldest arms of our immune system and is commonly recognized as a liver-derived and serum-active system critical for providing protection against invading pathogens. Recent unexpected findings, however, have defined novel and rather "uncommon" locations and activities of complement. Specifically, the discovery of an intracellularly active complement

    更新日期:2020-03-12
  • Metabolic determinants of lupus pathogenesis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-12
    Xiangyu Teng,Josephine Brown,Seung-Chul Choi,Wei Li,Laurence Morel

    The metabolism of healthy murine and more recently human immune cells has been investigated with an increasing amount of details. These studies have revealed the challenges presented by immune cells to respond rapidly to a wide variety of triggers by adjusting the amount, type, and utilization of the nutrients they import. A concept has emerged that cellular metabolic programs regulate the size of

    更新日期:2020-03-12
  • Visceral adipose tissue Tregs and the cells that nurture them.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-12
    Chaoran Li,Raul German Spallanzani,Diane Mathis

    Visceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also serves as an important endocrine organ that impacts organismal metabolism. Chronic, low-grade inflammation of VAT, and eventually systemically, is one of the major drivers of obesity-associated insulin resistance and metabolic abnormalities. A unique population of regulatory T cells (Tregs), with a distinct transcriptional

    更新日期:2020-03-12
  • The immunological Warburg effect: Can a metabolic-tumor-stroma score (MeTS) guide cancer immunotherapy?
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-10
    Peter J Siska,Katrin Singer,Katja Evert,Kathrin Renner,Marina Kreutz

    The "glycolytic switch" also known as the "Warburg effect" is a key feature of tumor cells and leads to the accumulation of lactate and protons in the tumor environment. Intriguingly, non-malignant lymphocytes or stromal cells such as tumor-associated macrophages and cancer-associated fibroblasts contribute to the lactate accumulation in the tumor environment, a phenomenon described as the "Reverse

    更新日期:2020-03-10
  • Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-10
    William J Turbitt,Claire Buchta Rosean,K Scott Weber,Lyse A Norian

    Obesity is an established risk factor for many cancers and has recently been found to alter the efficacy of T cell-based immunotherapies. Currently, however, the effects of obesity on immunometabolism remain unclear. Understanding these associations is critical, given the fact that T cell metabolism is tightly linked to effector function. Thus, any obesity-associated changes in T cell bioenergetics

    更新日期:2020-03-10
  • Metabolic adaptation orchestrates tissue context-dependent behavior in regulatory T cells.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-08
    Haiping Wang,Chun-Hao Lu,Ping-Chih Ho

    The diverse distribution and functions of regulatory T cells (Tregs) ensure tissue and immune homeostasis; however, it remains unclear which factors can guide distribution, local differentiation, and tissue context-specific behavior in Tregs. Although the emerging concept that Tregs could re-adjust their transcriptome based on their habitations is supported by recent findings, the underlying mechanisms

    更新日期:2020-03-08
  • Introduction: Evolution of inflammatory arthritis from innate to adaptive immune mechanisms.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-01
    Kristine A Kuhn,Thomas E Morrison
    更新日期:2020-02-27
  • Microbial orchestra in juvenile idiopathic arthritis: Sounds of disarray?
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-13
    Miika Arvonen,Petri Vänni,Aditya Narayan Sarangi,Mysore V Tejesvi,Paula Vähäsalo,Amita Aggarwal,Matthew L Stoll

    The role of the microbiota in multiple autoimmune diseases, including juvenile idiopathic arthritis (JIA) has earned substantial attention in the last 10 years. Increasing evidence suggests that the microbiota's link to JIA begins in early childhood, as early life events that influence the nature of the microbiota also appear to influence disease risk. In this review, we discuss these early life events

    更新日期:2020-02-27
  • Interleukin-23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-19
    Charlie Bridgewood,Kassem Sharif,Jonathan Sherlock,Abdulla Watad,Dennis McGonagle

    The inflammatory disorders collectively termed the seronegative spondyloarthropathies (SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the arthritis associated with inflammatory bowel disease including Crohn's disease and ulcerative colitis, the arthritis related to anterior uveitis, and finally, somewhat controversially Behcet's disease. All of these diseases

    更新日期:2020-02-27
  • Inflammasomes contributing to inflammation in arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-16
    Lotte Spel,Fabio Martinon

    Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory responses in response to pathogens and cellular damage. Active inflammasomes induce the enzymatic activity of caspase-1, resulting in the induction of inflammatory cell death, pyroptosis, and the maturation and secretion of inflammatory cytokines IL-1β and IL-18. Inflammasomes are activated in many inflammatory

    更新日期:2020-02-27
  • A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-13
    Michelle A E Brouwer,Freek R van de Schoor,Hedwig D Vrijmoeth,Mihai G Netea,Leo A B Joosten

    Articular joints are a major target of Borrelia burgdorferi, the causative agent of Lyme arthritis. Despite antibiotic treatment, recurrent or persistent Lyme arthritis is observed in a significant number of patients. The host immune response plays a crucial role in this chronic arthritic joint complication of Borrelia infections. During the early stages of B. burgdorferi infection, a major hinder

    更新日期:2020-02-27
  • Pathogenic Th1 responses in CHIKV-induced inflammation and their modulation upon Plasmodium parasites co-infection.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-26
    Anthony Torres-Ruesta,Teck-Hui Teo,Yi-Hao Chan,Laurent Rénia,Lisa F P Ng

    The induction of polyarthritis and polyarthralgia is a hallmark of arthritogenic alphavirus infections, with an exceptionally higher morbidity observed with chikungunya virus (CHIKV). While the mechanisms underlying these incapacitating acute symptoms remain partially understood, the progression to chronic conditions in some cases remains unanswered. The highly pro-inflammatory nature of alphavirus

    更新日期:2020-02-27
  • Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-19
    Georgiana Cabău,Tania O Crișan,Viola Klück,Radu A Popp,Leo A B Joosten

    Trained immunity is a process in which innate immune cells undergo functional reprogramming in response to pathogens or damage-associated molecules leading to an enhanced non-specific immune response to subsequent stimulation. While this capacity to respond more strongly to stimuli is beneficial for host defense, in some circumstances it can lead to maladaptive programming and chronic inflammation

    更新日期:2020-02-27
  • Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-13
    Laura C Cappelli,Mekha A Thomas,Clifton O Bingham,Ami A Shah,Erika Darrah

    The development of inflammatory arthritis in patients receiving immune checkpoint inhibitor therapy is increasingly recognized due to the growing use of these drugs for the treatment of cancer. This represents an important opportunity not only to define the mechanisms responsible for the development of this immune-related adverse event and to ultimately predict or prevent its development, but also

    更新日期:2020-02-27
  • Lung inflammation in the pathogenesis of rheumatoid arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-02-06
    M Kristen Demoruelle,Timothy M Wilson,Kevin D Deane

    The primary manifestation of rheumatoid arthritis (RA) is articular disease; however, extra-articular disease can also occur. In particular, pulmonary disease is a leading cause of morbidity and mortality in individuals with RA. Herein, we will review the types, prevalence, risk factors, and potential pathophysiology of lung disease in individuals with established RA. We will also discuss the emerging

    更新日期:2020-02-27
  • Insights into the study and origin of the citrullinome in rheumatoid arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-25
    Justyna Fert-Bober,Erika Darrah,Felipe Andrade

    The presence of autoantibodies and autoreactive T cells to citrullinated proteins and citrullinating enzymes in patients with rheumatoid arthritis (RA), together with the accumulation of citrullinated proteins in rheumatoid joints, provides substantial evidence that dysregulated citrullination is a hallmark feature of RA. However, understanding mechanisms that dysregulate citrullination in RA has important

    更新日期:2020-02-27
  • Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-16
    Mikhail Volkov,Karin Anna van Schie,Diane van der Woude

    Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In the last few decades, new insights into RA-specific autoantibodies and B cells have greatly expanded our understanding of the disease. The best-known autoantibodies in RA-rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA)-are present long before disease onset, and both responses show signs

    更新日期:2020-02-27
  • Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-16
    Yusuke Takeuchi,Keiji Hirota,Shimon Sakaguchi

    Mutations of the genes encoding T-cell receptor (TCR)-proximal signaling molecules, such as ZAP-70, can be causative of immunological diseases ranging from T-cell immunodeficiency to T-cell-mediated autoimmune disease. For example, SKG mice, which carry a hypomorphic point mutation of the Zap-70 gene, spontaneously develop T-cell-mediated autoimmune arthritis immunopathologically similar to human rheumatoid

    更新日期:2020-02-27
  • Immunometabolism in the development of rheumatoid arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-27
    Cornelia M Weyand,Jörg J Goronzy

    In rheumatoid arthritis (RA), breakdown of self-tolerance and onset of clinical disease are separated in time and space, supporting a multi-hit model in which emergence of autoreactive T cells is a pinnacle pathogenic event. Determining factors in T cell differentiation and survival include antigen recognition, but also the metabolic machinery that provides energy and biosynthetic molecules for cell

    更新日期:2020-02-27
  • Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-28
    Tiffany Amariuta,Yang Luo,Rachel Knevel,Yukinori Okada,Soumya Raychaudhuri

    Rheumatoid arthritis (RA) risk has a large genetic component (~60%) that is still not fully understood. This has hampered the design of effective treatments that could promise lifelong remission. RA is a polygenic disease with 106 known genome-wide significant associated loci and thousands of small effect causal variants. Our current understanding of RA risk has suggested cell-type-specific contexts

    更新日期:2020-02-27
  • Innate immunity to malaria-The role of monocytes.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-16
    Katherine R Dobbs,Juliet N Crabtree,Arlene E Dent

    Monocytes are innate immune cells essential for host protection against malaria. Upon activation, monocytes function to help reduce parasite burden through phagocytosis, cytokine production, and antigen presentation. However, monocytes have also been implicated in the pathogenesis of severe disease through production of damaging inflammatory cytokines, resulting in systemic inflammation and vascular

    更新日期:2020-01-06
  • Differentiation and adaptation of natural killer cells for anti-malarial immunity.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-24
    Martin R Goodier,Asia-Sophia Wolf,Eleanor M Riley

    Natural killer cells employ a diverse arsenal of effector mechanisms to target intracellular pathogens. Differentiation of natural killer (NK) cell activation pathways occurs along a continuum from reliance on innate pro-inflammatory cytokines and stress-induced host ligands through to interaction with signals derived from acquired immune responses. Importantly, the degree of functional differentiation

    更新日期:2020-01-06
  • Complement in malaria immunity and vaccines.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-09-26
    Liriye Kurtovic,Michelle J Boyle,D Herbert Opi,Alexander T Kennedy,Wai-Hong Tham,Linda Reiling,Jo-Anne Chan,James G Beeson

    Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this has proven to be immensely challenging over the decades. One major hindrance is the incomplete understanding of specific immune responses that confer protection against disease and/or infection. While antibodies to play a crucial role in malaria immunity, the functional

    更新日期:2020-01-06
  • B-cell memory in malaria: Myths and realities.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-16
    Damián Pérez-Mazliah,Francis M Ndungu,Racheal Aye,Jean Langhorne

    B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting B-cell memory has been shown to occur in response to Plasmodium spp. in experimental model infections, and in human malaria. However, there are reports that antibody responses to several

    更新日期:2020-01-06
  • The regulation of CD4+ T cells during malaria.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-01
    Rajiv Kumar,Jessica R Loughland,Susanna S Ng,Michelle J Boyle,Christian R Engwerda

    Malaria is a major global health problem. Despite decades of research, there is still no effective vaccine to prevent disease in the majority of people living in malaria-endemic regions. Additionally, drug treatment options are continually threatened by the emergence of drug-resistant parasites. Immune responses generated against Plasmodium parasites that cause malaria are generally not sufficient

    更新日期:2020-01-06
  • Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-01
    Komi Gbedande,Victor H Carpio,Robin Stephens

    Plasmodium falciparum infection and malaria remain a risk for millions of children and pregnant women. Here, we seek to integrate knowledge of mouse and human T helper cell (Th) responses to blood-stage Plasmodium infection to understand their contribution to protection and pathology. Although there is no complete Th subset differentiation, the adaptive response occurs in two phases in non-lethal rodent

    更新日期:2020-01-06
  • Deciphering host immunity to malaria using systems immunology.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-10-14
    Claire Loiseau,Martha M Cooper,Denise L Doolan

    A century of conceptual and technological advances in infectious disease research has changed the face of medicine. However, there remains a lack of effective interventions and a poor understanding of host immunity to the most significant and complex pathogens, including malaria. The development of successful interventions against such intractable diseases requires a comprehensive understanding of

    更新日期:2020-01-06
  • Decoding the complexities of human malaria through systems immunology.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-03
    Tuan M Tran,Peter D Crompton

    The complexity of the Plasmodium parasite and its life cycle poses a challenge to our understanding of the host immune response against malaria. Studying human immune responses during natural and experimental Plasmodium infections can enhance our understanding of malaria-protective immunity and inform the design of disease-modifying adjunctive therapies and next-generation malaria vaccines. Systems

    更新日期:2020-01-06
  • The immunology of Plasmodium vivax malaria.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-10-23
    Lis R Antonelli,Caroline Junqueira,Joseph M Vinetz,Douglas T Golenbock,Marcelo U Ferreira,Ricardo T Gazzinelli

    Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America, affects ~14 million individuals annually, with considerable adverse effects on wellbeing and socioeconomic development. A clinical hallmark of Plasmodium infection, the paroxysm, is driven by pyrogenic cytokines produced during the immune response. Here, we review studies on the role of specific immune cell types

    更新日期:2020-01-06
  • Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-16
    Roos M de Jong,Surafel K Tebeje,Lisette Meerstein-Kessel,Fitsum G Tadesse,Matthijs M Jore,Will Stone,Teun Bousema

    The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes. Here, we summarize evidence for naturally acquired anti-gametocyte immunity and the current state of transmission blocking vaccines (TBV). Although gametocytes are intra-erythrocytic when present in infected

    更新日期:2020-01-06
  • The immune response to malaria in utero.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-09-25
    Margaret E Feeney

    Malaria causes tremendous early childhood morbidity and mortality, providing an urgent impetus for the development of a vaccine that is effective in neonates. However, the infant immune response to malaria may be influenced by events that occur well before birth. Placental malaria infection complicates one quarter of all pregnancies in Africa and frequently results in exposure of the fetus to malaria

    更新日期:2020-01-06
  • Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-09-27
    Anja Ramstedt Jensen,Yvonne Adams,Lars Hviid

    Malaria, a mosquito-borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium-parasites have the unique capacity to infect and replicate within host erythrocytes. By expressing variant surface antigens Plasmodium falciparum has evolved to avoid protective immune responses; as a result in endemic areas anti-malaria

    更新日期:2020-01-06
  • Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-10-12
    Xi Zen Yap,Matthew B B McCall,Robert W Sauerwein

    Controlled human malaria infection (CHMI) is an established model in clinical malaria research. Upon exposure to Plasmodium falciparum parasites, malaria-naive volunteers differ in dynamics and composition of their immune profiles and subsequent capacity to generate protective immunity. CHMI volunteers are either inflammatory responders who have prominent cellular IFN-γ production primarily driven

    更新日期:2020-01-06
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