当前期刊: Immunological Reviews Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Beyond CAR T cells: Engineered Vγ9Vδ2 T cells to fight solid tumors
    Immunol. Rev. (IF 13.939) Pub Date : 2020-09-23
    Chirine Rafia; Christelle Harly; Emmanuel Scotet

    Despite recent significant progress in cancer immunotherapies based on adoptive cell transfer(s)(ACT), the eradication of cancers still represents a major clinical challenge. In particular, the efficacy of current ACT‐based therapies against solid tumors is dramatically reduced by physical barriers that prevent tumor infiltration of adoptively transferred effectors, and the tumor environment that suppress

    更新日期:2020-09-23
  • Cancer immunotherapy harnessing γδ T cells and programmed death-1.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-09-05
    Yoshimasa Tanaka

    Cancer immunotherapy has received increasing attention since the success of CTLA‐4 and programmed death‐1 (PD‐1) immune checkpoint inhibitors and CAR‐T cells. One of the most promising next‐generation cancer treatments is adoptive transfer of immune effector cells. Developing an efficacious adoptive transfer therapy requires growing large numbers of highly purified immune effector cells in a short

    更新日期:2020-09-06
  • Intracellular innate immune receptors: Life inside the cell.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-27
    Thirumala-Devi Kanneganti
    更新日期:2020-08-28
  • The NLRP1 and CARD8 inflammasomes.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-19
    Cornelius Y Taabazuing,Andrew R Griswold,Daniel A Bachovchin

    Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are related germline‐encoded pattern recognition receptors that form inflammasomes, but their activation mechanisms and biological purposes have not yet been fully established. Both NLRP1 and CARD8 undergo post‐translational autoproteolysis

    更新日期:2020-08-28
  • The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis).
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-29
    Min Zheng,Thirumala-Devi Kanneganti

    ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced during influenza virus infection induces cell death in the form of pyroptosis, apoptosis, and necroptosis (PANoptosis). PANoptosis is a coordinated cell death pathway that is driven through a multiprotein complex called the PANoptosome

    更新日期:2020-08-28
  • Pyroptotic and non-pyroptotic effector functions of caspase-11.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-01
    Arwa Abu Khweek,Amal O Amer

    Innate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response. Inflammasomes are highly sophisticated and effective orchestrators of innate immunity. These oligomerized multiprotein complexes are at the center of various innate immune pathways, including modulation of the cytoskeleton, production and maturation

    更新日期:2020-08-28
  • Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    Valerie Harrington,Prajwal Gurung

    Leishmaniasis is a global health problem that affects more than 2 billion people worldwide. Recent advances in research have demonstrated critical roles for cytoplasmic sensors and inflammasomes during Leishmania spp. infection and pathogenesis. Specifically, several studies have focused on the role of nod‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome and inflammasome‐associated

    更新日期:2020-08-28
  • Molecular mechanisms activating the NAIP-NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-29
    Callum Kay,Runli Wang,Max Kirkby,Si Ming Man

    Cytosolic innate immune sensing is a cornerstone of innate immunity in mammalian cells and provides a surveillance system for invading pathogens and endogenous danger signals. The NAIP‐NLRC4 inflammasome responds to cytosolic flagellin, and the inner rod and needle proteins of the type 3 secretion system of bacteria. This complex induces caspase‐1‐dependent proteolytic cleavage of the proinflammatory

    更新日期:2020-08-28
  • AIM2 in health and disease: Inflammasome and beyond.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-26
    Puja Kumari,Ashley J Russo,Sonia Shivcharan,Vijay A Rathinam

    Nucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and the nucleus. Sensing of microbial DNA through these receptors stimulates, in most cases, interferon regulatory factor‐dependent type I IFN synthesis followed

    更新日期:2020-08-28
  • The pyrin inflammasome and the Yersinia effector interaction.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-28
    Haleema S Malik,James B Bliska

    Pyrin is a cytosolic pattern‐recognition receptor that normally functions as a guard to trigger capase‐1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. The MEFV gene encoding human pyrin is preferentially expressed in phagocytes. Key domains in pyrin include a pyrin domain (PYD), a linker region, and a B30.2 domain. Binding of ASC to pyrin by a PYD‐PYD interaction

    更新日期:2020-08-28
  • Lipids, inflammasomes, metabolism, and disease.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    Paras K Anand

    Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death, pyroptosis. Several members of the nod‐like receptor family assemble inflammasome in response to specific ligands. An exception to this is the NLRP3 inflammasome which is activated by structurally diverse entities. Recent

    更新日期:2020-08-28
  • Therapeutic modulation of inflammasome pathways.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-07
    Dhruv Chauhan,Lieselotte Vande Walle,Mohamed Lamkanfi

    Inflammasomes are macromolecular complexes formed in response to pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) that drive maturation of the pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18, and cleave gasdermin D (GSDMD) for induction of pyroptosis. Inflammasomes are highly important in protecting the host from various microbial pathogens and

    更新日期:2020-08-28
  • NOD1 and NOD2 in inflammatory and infectious diseases.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-17
    Bruno C Trindade,Grace Y Chen

    It has been long recognized that NOD1 and NOD2 are critical players in the host immune response, primarily by their sensing bacterial peptidoglycan‐conserved motifs. Significant advances have been made from efforts that characterize their upstream activators, assembly of signaling complexes, and activation of downstream signaling pathways. Disruption in NOD1 and NOD2 signaling has also been associated

    更新日期:2020-08-28
  • Nuclear innate sensors for nucleic acids in immunity and inflammation.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    Hongyu Lin,Xuetao Cao

    Innate sensors recognize pathogen‐associated molecular patterns (PAMPs) or damage‐associated molecular patterns (DAMPs) to initiate innate immune response by activating downstream signaling. These evolutionarily conserved innate sensors usually locate in the plasma membrane or cytoplasm. However, the nucleus‐localized innate sensors are recently found to detect pathogenic nucleic acids for initiating

    更新日期:2020-08-28
  • Cross talk between intracellular pathogens and cell death.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-22
    Benjamin Demarco,Kaiwen W Chen,Petr Broz

    Infections with bacterial pathogens often results in the initiation of programmed cell death as part of the host innate immune defense, or as a bacterial virulence strategy. Induction of host cell death is controlled by an elaborate network of innate immune and cell death signaling pathways and manifests in different morphologically and functionally distinct forms of death, such as apoptosis, necroptosis

    更新日期:2020-08-28
  • What came first, the virus or the egg: Innate immunity during viral coinfections.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-06
    Meagan D Rippee-Brooks,Riley N Marcinczyk,Christopher R Lupfer

    Infections with any pathogen can be severe and present with numerous complications caused by the pathogen or the host immune response to the invading microbe. However, coinfections, also called polymicrobial infections or secondary infections, can further exacerbate disease. Coinfections are more common than is often appreciated. In this review, we focus specifically on coinfections between viruses

    更新日期:2020-08-28
  • The microbiome and cytosolic innate immune receptors.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-13
    Timur Liwinski,Danping Zheng,Eran Elinav

    The discovery of innate immune sensors (pattern recognition receptors, PRRs) has profoundly transformed the notion of innate immunity, in providing a mechanistic basis for host immune interactions with a wealth of environmental signals, leading to a variety of immune‐mediated outcomes including instruction and activation of the adaptive immune arm. As part of this growing understanding of host‐environmental

    更新日期:2020-08-28
  • The role of innate immunity in Alzheimer's disease.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-26
    Hannah E Ennerfelt,John R Lukens

    The amyloid hypothesis has dominated Alzheimer's disease (AD) research for almost 30 years. This hypothesis hinges on the predominant clinical role of the amyloid beta (Aβ) peptide in propagating neurofibrillary tangles (NFTs) and eventual cognitive impairment in AD. Recent research in the AD field has identified the brain‐resident macrophages, known as microglia, and their receptors as integral regulators

    更新日期:2020-08-28
  • Primary immunodeficiencies in cytosolic pattern-recognition receptor pathways: Toward host-directed treatment strategies.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-08
    Caspar I van der Made,Alexander Hoischen,Mihai G Netea,Frank L van de Veerdonk

    In the last decade, the paradigm of primary immunodeficiencies (PIDs) as rare recessive familial diseases that lead to broad, severe, and early‐onset immunological defects has shifted toward collectively more common, but sporadic autosomal dominantly inherited isolated defects in the immune response. Patients with PIDs constitute a formidable area of research to study the genetics and the molecular

    更新日期:2020-08-28
  • γδ T cells and inflammatory skin diseases.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-27
    Mia Hamilton Jee,Veronika Mraz,Carsten Geisler,Charlotte Menné Bonefeld

    Approximately 25% of the population suffers from skin diseases. The most common forms of skin diseases are the inflammatory skin diseases such as allergic contact dermatitis, psoriasis, and atopic dermatitis. These diseases are described as T cell–mediated diseases induced by either allergens or autoantigens. Classically, the focus has been on the role of αβ T cells, but it is becoming increasingly

    更新日期:2020-08-27
  • γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-26
    Matthew A Fischer,Natasha B Golovchenko,Karen L Edelblum

    γδ T cells are found in highest numbers at barrier surfaces throughout the body, including the skin, intestine, lung, gingiva, and uterus. Under homeostatic conditions, γδ T cells provide immune surveillance of the epidermis, intestinal, and oral mucosa, whereas the presence of pathogenic microorganisms in the dermis or lungs elicits a robust γδ17 response to clear the infection. Although T cell migration

    更新日期:2020-08-27
  • Gut γδ T cells as guardians, disruptors, and instigators of cancer.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-08-24
    Toshiyasu Suzuki,Liam Hayman,Anna Kilbey,Joanne Edwards,Seth B Coffelt

    Colorectal cancer is the third most common cancer worldwide with nearly 2 million cases per year. Immune cells and inflammation are a critical component of colorectal cancer progression, and they are used as reliable prognostic indicators of patient outcome. With the growing appreciation for immunology in colorectal cancer, interest is growing on the role γδ T cells have to play, as they represent

    更新日期:2020-08-25
  • Two functionally distinct subsets of IL-17 producing γδ T cells.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-22
    Rebecca L O'Brien,Willi K Born

    The γδ T cells play an important role in both mice and humans as a source of the cytokine IL‐17, which is key for immune resistance to certain pathogens. In mice, most of these IL‐17 producers, termed γδT‐17 cells, actually comprise two distinct types: those expressing an invariant Vγ6Vδ1+ TCR and those expressing a Vγ4+ TCR. Murine γδT‐17 cells acquire an inherent bias to produce IL‐17 and other “type

    更新日期:2020-07-23
  • Deciphering human γδ T cell response in cancer: Lessons from tumor-infiltrating γδ T cells.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-20
    Elena Lo Presti,Francesco Dieli,Jean Jacques Fourniè,Serena Meraviglia

    The finding that γδ T cells are present among tumor‐infiltrating lymphocytes in humans suggests they participate in tumor immune surveillance, but their relevance is unclear because the relative abundance of tumor‐infiltrating γδ T cells correlates with positive or negative, or even do not correlate with prognosis. This likely depends on the fact that tumor‐infiltrating γδ T cells may play substantially

    更新日期:2020-07-21
  • B and Th cell response to Ag in vivo: Implications for vaccine development and diseases.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-19
    Richard B Kennedy,Irina Grigorova

    While vaccines have been the major medical intervention in human history that fundamentally reshaped our life‐expectancy, the global COVID‐19 pandemic reinforced public awareness about the critical need for further advancement of vaccine development. Multiple groups have published on improved and directed efforts to develop vaccines—efforts that are informed by the most up‐to‐date understanding of

    更新日期:2020-07-20
  • Signals 1, 2 and B cell fate or: Where, when and for how long?
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-29
    Jackson S Turner,Zachary L Benet,Irina L Grigorova

    Diverse B cell responses are important for generating antibody‐mediated protection against highly variable pathogens. While some antigens can trigger T‐independent B cell proliferation and short‐term antibody production, development of long‐term humoral immunity requires T‐dependent B cell responses. The “two‐signal” model of B cell activation has long been invoked to explain alternate B cell recruitment

    更新日期:2020-07-20
  • T cell help to B cells: Cognate and atypical interactions in peripheral and intestinal lymphoid tissues.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-18
    Adi Biram,Ziv Shulman

    Enduring immunity against harmful pathogens depends on the generation of immunological memory. Serum immunoglobulins are constantly secreted by long‐lived antibody‐producing cells, which provide extended protection from recurrent exposures. These cells originate mainly from germinal center structures, wherein B cells introduce mutations to their immunoglobulin genes followed by affinity‐based selection

    更新日期:2020-07-20
  • T follicular helper cells in germinal center B cell selection and lymphomagenesis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-15
    Michelle A Mintz,Jason G Cyster

    Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long‐lived plasma cells. GCs are also the origin of malignancy, namely follicular lymphoma (FL), GC B cell‐diffuse large B cell lymphoma (GCB‐DLBCL), and Burkitt lymphoma (BL). GC B cell lymphomas maintain their GC transcriptional

    更新日期:2020-07-20
  • The geography of memory B cell reactivation in vaccine-induced immunity and in autoimmune disease relapses.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-30
    Rama Dhenni,Tri Giang Phan

    Memory B cells (Bmem) provide an active second layer of defense against re‐infection by pathogens that have bypassed the passive first layer provided by neutralizing antibodies. Here, we review recent progress in our understanding of Bmem heterogeneity in terms of their origin (germinal center‐dependent vs center‐independent), phenotype (canonical vs atypical vs age‐associated B cells), trafficking

    更新日期:2020-07-20
  • How intrinsic and extrinsic regulators of plasma cell survival might intersect for durable humoral immunity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-26
    Marcus J Robinson,Rosela H Webster,David M Tarlinton

    Plasma cells (PC) are key to protective immunity because they secrete antibodies. Surviving for periods ranging from days to decades in mammals, PC possess varying survival times that cannot be entirely stochastic or extrinsically set, as presumed half‐lives vary with antigenic specificity. Here, we review the signals that impart survival potential to PC. These include signals provided during formation

    更新日期:2020-07-20
  • Control of foreign Ag-specific Ab responses by Treg and Tfr.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-20
    James B Wing,Ee Lyn Lim,Shimon Sakaguchi

    Regulatory T cells (Tregs) expressing the transcription factor Foxp3 play a critical role in the control of immune homeostasis including the regulation of humoral immunity. Recently, it has become clear that a specialized subset of Tregs, T‐follicular regulatory cells (Tfr), have a particular role in the control of T‐follicular helper (Tfh) cell‐driven germinal center (GC) responses. Following similar

    更新日期:2020-07-20
  • Factors in B cell competition and immunodominance.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-01
    Robert K Abbott,Shane Crotty

    The majority of all vaccines work by inducing protective antibody responses. The mechanisms by which the B cells responsible for producing protective antibodies are elicited to respond are not well understood. Interclonal B cell competition to complex antigens, particularly in germinal centers, has emerged as an important hurdle in designing effective vaccines. This review will focus on recent advances

    更新日期:2020-07-20
  • Influenza vaccination strategies targeting the hemagglutinin stem region.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-16
    Hidehiro Fukuyama,Ryo Shinnakasu,Tomohiro Kurosaki

    Influenza is one of the best examples of highly mutable viruses that are able to escape immune surveillance. Indeed, in response to influenza seasonal infection or vaccination, the majority of the induced antibodies are strain‐specific. Current vaccine against the seasonal strains with the strategy of surveillance‐prediction‐vaccine does not cover an unmet virus strain leading to pandemic. Recently

    更新日期:2020-07-20
  • Age-related factors that affect B cell responses to vaccination in mice and humans.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-02
    Daniela Frasca,Bonnie B Blomberg,Denisse Garcia,Spencer R Keilich,Laura Haynes

    Aging significantly changes the ability to respond to vaccinations and infections. In this review, we summarize published results on age‐related changes in response to infection with the influenza virus and on the factors known to increase influenza risk infection leading to organ failure and death. We also summarize how aging affects the response to the influenza vaccine with a special focus on B

    更新日期:2020-07-20
  • The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics".
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-30
    Mona O Mohsen,Gilles Augusto,Martin F Bachmann

    Vaccines need to be rationally designed in order be delivered to the immune system for maximizing induction of dynamic immune responses. Virus‐like particles (VLPs) are ideal platforms for such 3D vaccines, as they allow the display of complex and native antigens in a highly repetitive form on their surface and can easily reach lymphoid organs in intact form for optimal activation of B and T cells

    更新日期:2020-07-20
  • Modulation of immune responses using adjuvants to facilitate therapeutic vaccination.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-06-28
    Virgil Schijns,Alberto Fernández-Tejada,Žarko Barjaktarović,Ilias Bouzalas,Jens Brimnes,Sergey Chernysh,Sveinbjorn Gizurarson,Ihsan Gursel,Žiga Jakopin,Maria Lawrenz,Cristina Nativi,Stephane Paul,Gabriel Kristian Pedersen,Camillo Rosano,Ane Ruiz-de-Angulo,Bram Slütter,Aneesh Thakur,Dennis Christensen,Ed C Lavelle

    Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non‐infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination can at least in principle be proposed as a therapeutic strategy. Understanding the nature of protective immunity is of vital importance, and the progress made in recent years in defining

    更新日期:2020-07-20
  • Imprinting, immunodominance, and other impediments to generating broad influenza immunity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-14
    Matthew Knight,Siriruk Changrob,Lei Li,Patrick C Wilson

    Natural influenza virus infections and seasonal vaccinations often do not confer broadly neutralizing immunity across diverse influenza strains. In addition, the virus is capable of rapid antigenic drift in order to evade pre‐existing immunity. The surface glycoproteins, hemagglutinin, and neuraminidase can easily mutate their immunodominant epitopes without impacting fitness. Skewing human antibody

    更新日期:2020-07-20
  • The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-07-13
    Inna G Ovsyannikova,Iana H Haralambieva,Stephen N Crooke,Gregory A Poland,Richard B Kennedy

    This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus‐mediated disease. The initial sections focus on seasonal coronaviruses, SARS‐CoV, and MERS‐CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS‐CoV‐2 and

    更新日期:2020-07-20
  • Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-23
    Federico Martinelli,Anna Perrone,Isabella Della Noce,Lorenzo Colombo,Stefano Lo Priore,Simone Romano

    The ongoing outbreak of the novel coronavirus (SARS-CoV-2) infection is creating serious challenges for health laboratories that seek to identify viral infections as early as possible, optimally at the earliest appearance of symptom. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where

    更新日期:2020-04-24
  • Immunometabolism: From basic mechanisms to translation.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-01
    Liza Makowski,Mehdi Chaib,Jeffrey C Rathmell

    Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were induced in obese adipose tissue and that these cytokines contributed to metabolic disease, it was clear that metabolism and the immunological state are inextricably linked. With a second research wave arising from studies in cancer metabolism to

    更新日期:2020-04-23
  • Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-01
    Azadeh Bahadoran,Lavanya Bezavada,Heather S Smallwood

    Recent studies support the notion that glycolysis and oxidative phosphorylation are rheostats in immune cells whose bioenergetics have functional outputs in terms of their biology. Specific intrinsic and extrinsic molecular factors function as molecular potentiometers to adjust and control glycolytic to respiratory power output. In many cases, these potentiometers are used by influenza viruses and

    更新日期:2020-04-23
  • Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-05-01
    Laura M Sipe,Mehdi Chaib,Ajeeth K Pingili,Joseph F Pierre,Liza Makowski

    Bile acids (BAs) are known facilitators of nutrient absorption but recent paradigm shifts now recognize BAs as signaling molecules regulating both innate and adaptive immunity. Bile acids are synthesized from cholesterol in the liver with subsequent microbial modification and fermentation adding complexity to pool composition. Bile acids act on several receptors such as Farnesoid X Receptor and the

    更新日期:2020-04-23
  • The role of B cell antigen presentation in the initiation of CD4+ T cell response.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-18
    Zhaolin Hua,Baidong Hou

    B cells have been known for their ability to present antigens to T cells for almost 40 years. However, the precise roles of B cell antigen presentation in various immune responses are not completely understood. The term “professional” antigen‐presenting cells (APCs) was proposed to distinguish APCs that are required for initiating the immune responses from those use antigen presentation to enhance

    更新日期:2020-04-18
  • Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-03
    Nikki van Teijlingen Bakker,Edward J Pearce

    We have only recently started to appreciate the extent to which immune cell activation involves significant changes in cellular metabolism. We are now beginning to understand how commitment to specific metabolic pathways influences aspects of cellular biology that are the more usual focus of immunological studies, such as activation-induced changes in gene transcription, post-transcriptional regulation

    更新日期:2020-04-03
  • Adipose tissue macrophages: Unique polarization and bioenergetics in obesity.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-04-01
    Heather L Caslin,Monica Bhanot,W Reid Bolus,Alyssa H Hasty

    Macrophages comprise a majority of the resident immune cells in adipose tissue (AT) and regulate both tissue homeostasis in the lean state and metabolic dysregulation in obesity. Since the AT environment rapidly changes based upon systemic energy status, AT macrophages (ATMs) must adapt phenotypically and metabolically. There is a distinct dichotomy in the polarization and bioenergetics of in vitro

    更新日期:2020-04-01
  • Chemical individuality in T cells: A Garrodian view of immunometabolism.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-31
    Peter J McGuire

    Metabolically quiescent T cells circulate throughout the body in search of antigen. Following engagement of their cognate receptors, T cells undergo metabolic reprogramming to support their activation, differentiation, and ultimately function. In the spirit of Sir Archibald Garrod, this metabolic reprogramming actually imparts a chemical individuality which confers advantage, while in others confers

    更新日期:2020-03-31
  • mTOR signaling at the crossroads of environmental signals and T-cell fate decisions.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-25
    Hongling Huang,Lingyun Long,Peipei Zhou,Nicole M Chapman,Hongbo Chi

    The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates signals from the environment to coordinate downstream signaling events and various cellular processes. T cells rely on mTOR activity for their development and to establish their homeostasis and functional fitness. Here, we review recent progress

    更新日期:2020-03-25
  • The role of metabolic checkpoint regulators in B cell survival and transformation.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-17
    Julia Jellusova

    In response to mitogenic stimulation, B cells activate different pro-anabolic signaling pathways such as c-Myc- and mTORC1-dependent networks to satisfy the energetic demands of biomass synthesis and proliferation. In order to preserve viability and function, cell growth cannot progress unchecked and must be adjusted according to the availability of nutrients. Nutrient-sensing proteins such as AMPK

    更新日期:2020-03-17
  • Complement and human T cell metabolism: Location, location, location.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-12
    Erin E West,Natalia Kunz,Claudia Kemper

    The complement system represents one of the evolutionary oldest arms of our immune system and is commonly recognized as a liver-derived and serum-active system critical for providing protection against invading pathogens. Recent unexpected findings, however, have defined novel and rather "uncommon" locations and activities of complement. Specifically, the discovery of an intracellularly active complement

    更新日期:2020-03-12
  • Metabolic determinants of lupus pathogenesis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-12
    Xiangyu Teng,Josephine Brown,Seung-Chul Choi,Wei Li,Laurence Morel

    The metabolism of healthy murine and more recently human immune cells has been investigated with an increasing amount of details. These studies have revealed the challenges presented by immune cells to respond rapidly to a wide variety of triggers by adjusting the amount, type, and utilization of the nutrients they import. A concept has emerged that cellular metabolic programs regulate the size of

    更新日期:2020-03-12
  • Visceral adipose tissue Tregs and the cells that nurture them.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-12
    Chaoran Li,Raul German Spallanzani,Diane Mathis

    Visceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also serves as an important endocrine organ that impacts organismal metabolism. Chronic, low-grade inflammation of VAT, and eventually systemically, is one of the major drivers of obesity-associated insulin resistance and metabolic abnormalities. A unique population of regulatory T cells (Tregs), with a distinct transcriptional

    更新日期:2020-03-12
  • The immunological Warburg effect: Can a metabolic-tumor-stroma score (MeTS) guide cancer immunotherapy?
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-10
    Peter J Siska,Katrin Singer,Katja Evert,Kathrin Renner,Marina Kreutz

    The "glycolytic switch" also known as the "Warburg effect" is a key feature of tumor cells and leads to the accumulation of lactate and protons in the tumor environment. Intriguingly, non-malignant lymphocytes or stromal cells such as tumor-associated macrophages and cancer-associated fibroblasts contribute to the lactate accumulation in the tumor environment, a phenomenon described as the "Reverse

    更新日期:2020-03-10
  • Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-10
    William J Turbitt,Claire Buchta Rosean,K Scott Weber,Lyse A Norian

    Obesity is an established risk factor for many cancers and has recently been found to alter the efficacy of T cell-based immunotherapies. Currently, however, the effects of obesity on immunometabolism remain unclear. Understanding these associations is critical, given the fact that T cell metabolism is tightly linked to effector function. Thus, any obesity-associated changes in T cell bioenergetics

    更新日期:2020-03-10
  • Metabolic adaptation orchestrates tissue context-dependent behavior in regulatory T cells.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-08
    Haiping Wang,Chun-Hao Lu,Ping-Chih Ho

    The diverse distribution and functions of regulatory T cells (Tregs) ensure tissue and immune homeostasis; however, it remains unclear which factors can guide distribution, local differentiation, and tissue context-specific behavior in Tregs. Although the emerging concept that Tregs could re-adjust their transcriptome based on their habitations is supported by recent findings, the underlying mechanisms

    更新日期:2020-03-08
  • Introduction: Evolution of inflammatory arthritis from innate to adaptive immune mechanisms.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-03-01
    Kristine A Kuhn,Thomas E Morrison
    更新日期:2020-02-27
  • Microbial orchestra in juvenile idiopathic arthritis: Sounds of disarray?
    Immunol. Rev. (IF 13.939) Pub Date : 2019-12-13
    Miika Arvonen,Petri Vänni,Aditya Narayan Sarangi,Mysore V Tejesvi,Paula Vähäsalo,Amita Aggarwal,Matthew L Stoll

    The role of the microbiota in multiple autoimmune diseases, including juvenile idiopathic arthritis (JIA) has earned substantial attention in the last 10 years. Increasing evidence suggests that the microbiota's link to JIA begins in early childhood, as early life events that influence the nature of the microbiota also appear to influence disease risk. In this review, we discuss these early life events

    更新日期:2020-02-27
  • Interleukin-23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-19
    Charlie Bridgewood,Kassem Sharif,Jonathan Sherlock,Abdulla Watad,Dennis McGonagle

    The inflammatory disorders collectively termed the seronegative spondyloarthropathies (SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the arthritis associated with inflammatory bowel disease including Crohn's disease and ulcerative colitis, the arthritis related to anterior uveitis, and finally, somewhat controversially Behcet's disease. All of these diseases

    更新日期:2020-02-27
  • Inflammasomes contributing to inflammation in arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-16
    Lotte Spel,Fabio Martinon

    Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory responses in response to pathogens and cellular damage. Active inflammasomes induce the enzymatic activity of caspase-1, resulting in the induction of inflammatory cell death, pyroptosis, and the maturation and secretion of inflammatory cytokines IL-1β and IL-18. Inflammasomes are activated in many inflammatory

    更新日期:2020-02-27
  • A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.
    Immunol. Rev. (IF 13.939) Pub Date : 2020-01-13
    Michelle A E Brouwer,Freek R van de Schoor,Hedwig D Vrijmoeth,Mihai G Netea,Leo A B Joosten

    Articular joints are a major target of Borrelia burgdorferi, the causative agent of Lyme arthritis. Despite antibiotic treatment, recurrent or persistent Lyme arthritis is observed in a significant number of patients. The host immune response plays a crucial role in this chronic arthritic joint complication of Borrelia infections. During the early stages of B. burgdorferi infection, a major hinder

    更新日期:2020-02-27
  • Pathogenic Th1 responses in CHIKV-induced inflammation and their modulation upon Plasmodium parasites co-infection.
    Immunol. Rev. (IF 13.939) Pub Date : 2019-11-26
    Anthony Torres-Ruesta,Teck-Hui Teo,Yi-Hao Chan,Laurent Rénia,Lisa F P Ng

    The induction of polyarthritis and polyarthralgia is a hallmark of arthritogenic alphavirus infections, with an exceptionally higher morbidity observed with chikungunya virus (CHIKV). While the mechanisms underlying these incapacitating acute symptoms remain partially understood, the progression to chronic conditions in some cases remains unanswered. The highly pro-inflammatory nature of alphavirus

    更新日期:2020-02-27
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
物理学研究前沿热点精选期刊推荐
chemistry
《自然》编辑与您分享如何成为优质审稿人-信息流
欢迎报名注册2020量子在线大会
化学领域亟待解决的问题
材料学研究精选新
GIANT
自然职场线上招聘会
ACS ES&T Engineering
ACS ES&T Water
ACS Publications填问卷
屿渡论文,编辑服务
阿拉丁试剂right
张晓晨
田蕾蕾
李闯创
刘天飞
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界