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Articular involvement in Henoch-Schönlein Purpura: A review of literature. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Victor Gonzalez-Uribe,Ricardo Martínez-Tenopala,Ana Paula Solórzano-Anduiza,María Fernández-De La Torre,Zaira S Mojica-Gonzalez
BACKGROUND Henoch-Schönlein purpura (HSP), the most typical kind of pediatric vasculitis, can also affect adults. Over the last 10 years, research has been increasing on improvements in HSP diagnosis, physiopathology, symptoms, and therapy. Joint involvement is highly frequent in this condition; however, it typically undergoes spontaneous resolution and does not lead to long-term complications. OBJECTIVE
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Antituberculosis drug-induced non-blistering systemic severe reactions: A 10-year (2012-2022) literature review. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Angela Rizzi,Eleonora Nucera,Sara Urbani,David Longhino,Franziska Michaela Lohmeyer,Giovanni Gambassi,Nateetip Krishnamra,Luca Gammeri,Sebastiano Gangemi,Riccardo Inchingolo
Drug reaction with eosinophilia and systemic symptoms (DRESS) and drug-induced liver injury (DILI) can hamper therapeutic strategy, contribute to multiple drug resistance and serious public health burden. Diagnosis (including allergy assessment) and management of these two severe hypersensitivity reactions in clinical practice are somewhat difficult and published scientific evidence is rather weak
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Benefits of mobile messenger application in caregivers of food allergy children. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Kranjana Chayutimaphan,Jetsada Arnin,Adithep Sawatchai,Watcharoot Kanchongkittiphon,Wiparat Manuyakorn
BACKGROUND Unintentional exposure is common in children with food allergies. OBJECTIVE To assess the benefits of newly developed food allergy application. METHODS Caregivers of children with confirmed immediate reactions to food were enrolled to use the "Kinchew" application for one month. Kinchew provides the detail of food allergens after typing the name of specific food in the chat box. Then, the
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Validity and reliability of the Thai version of Food Allergy Quality of Life Questionnaire - Adult Form (FAQLQ-AF) and Food Allergy Independent Measure - Adult Form (FAIM-AF). Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Chayapat Tangwiwat,Mongkhon Sompornrattanaphan,Torpong Thongngarm,Chamard Wongsa
BACKGROUND Food allergy affects the patient's quality of life (QoL) and leads to anxiety and depression. In addition to routine treatment, QoL evaluation should also be performed in patients with food allergies. The validated Food Allergy Quality of Life Questionnaire - Adult Form (FAQLQ-AF) and Food Allergy Independent Measure - Adult Form (FAIM-AF) have been well accepted and available in many languages
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Bronchoalveolar lavage fluid cytokines and chemokines changes after bronchial thermoplasty in severe asthma. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Nophol Leelayuwatanakul,Pimpayao Sodsai,Ketsupar Jirakran,Vorawut Thanthitaweewat,Virissorn Wongsrichanalai,Thitiwat Sriprasart
BACKGROUND Bronchial thermoplasty (BT) is a non-pharmacological intervention in severe asthma with a well-known mechanism of reducing airway smooth muscle. However, its effect on airway inflammation remains uncertain. OBJECTIVE To investigate the effect of BT on bronchoalveolar lavage fluid (BALF) cytokines and chemokines in severe asthma patients before BT, after the first BT, and 12 weeks after BT
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Meta-analysis and cost-effectiveness analysis of intranasal corticosteroid treatment in allergic rhinitis with ocular symptoms. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Chadakan Yan,Phichayut Phinyo,Bussakorn Mahakkanukrauh,Torsak Bunupuradah,Manish Verma,Abhay Phansalkar,Bhumika Aggarwal
BACKGROUND Intranasal corticosteroid (INCS) has a beneficial effect on ocular symptoms in allergic rhinitis (AR). To our knowledge, the cost-effectiveness of available INCS for AR with ocular symptoms is yet to be demonstrated. OBJECTIVE To evaluate the cost-effectiveness of INCSs including Budesonide (BANS), Mometasone furoate (MFNS), Triamcinolone (TANS), and Fluticasone furoate (FFNS) on ocular
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Global COVID-19 Vaccination in Infants and Children: Effectiveness, Safety, and Challenges. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-23 Watsamon Jantarabenjakul,Napaporn Chantasrisawad,Rapisa Nantanee,Sateesh Ganguli,Thanyawee Puthanakit
COVID-19 Vaccines, which include mRNA and inactivated vaccines, have been proven effective and safe for infants and children aged more than six months in reducing the severity of the disease, hospitalization, multisystem inflammatory syndrome in children, and death. Nonetheless, the real-world effectiveness of these vaccines in preventing infection is generally lower than in clinical trials due to
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Unveiling the role of neutrophils in chronic spontaneous urticaria: Beyond mast cells. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-10-7 Kanokvalai Kulthanan, Leena Chularojanamontri, Papapit Tuchinda, Panyapat Buranaporn, Ekapun Karoopongse
Mast cells and eosinophils are considered pivotal contributors to the pathogenesis of chronic spontaneous urticaria (CSU). However, emerging evidence suggests that neutrophils also play a central role. Cutaneous mast cells and macrophages orchestrate the recruitment of neutrophils through the regulation and activation of diverse processes, including heightened local vascular permeability and chemokine
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Therapeutic effectiveness of probiotics for atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials with subgroup analysis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-08-14 Kyunghoon Kim,Eun Lee,Mina Kim,Kyung Suk Lee,In Suk Sol,Taek Ki Min,Hyeon-Jong Yang,Soo-Jong Hong
BACKGROUND The effect of probiotics in the treatment of atopic dermatitis (AD) is inconclusive, partially due to the heterogeneities of AD. OBJECTIVE The aim of the present study was to investigate the efficacy of probiotics in the treatment of AD with a subgroup analysis according to country, severity of AD, duration of supplementation, and probiotic strain. METHODS Original articles reporting the
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Identifying the stability of a new wheat gliadin extract by protein analysis, skin tests and cell degranulation assay. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-08-14 Chortip Chansangsawat,Surapon Piboonpocanun,Pisit Ubonsri,Punchama Pacharn,Witchaya Srisuwatchari,Kantima Kanchanapoomi,Nualanong Visitsunthorn,Orathai Jirapongsananuruk
BACKGROUND The commercial wheat extract for skin prick test (SPT) provides less sensitivity to predict wheat allergy, compared to in-house gliadin extracts. SPT is a preferred method to study extract stability as it is the aim of developing extract. The role of cell degranulation assay, a functional assay with the same mechanism as SPT, is not widely used to determine extract stability. OBJECTIVE To
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Effect of dyslipidemia, obesity, and atopic status on exhaled and alveolar nitric oxide in asthmatic children. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-08-14 Pakvirin Nanakorn Chanachon,Adithep Sawatchai,Wanlapa Jotikasthira,Potjanee Kiewngam,Watcharoot Kanchongkittiphon,Wiparat Manuyakorn
BACKGROUND Dyslipidemia and obesity contribute to a pro-inflammatory state. Eosinophilic airway inflammation can be indirectly measured by fractional exhaled nitric oxide (FeNO) produced in the airways of asthmatic subjects. OBJECTIVE To compare exhaled nitric oxide (NO) and alveolar NO in asthmatic children with and without dyslipidemia. METHODS Asthmatic children (5-18 years old) had fasting serum
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Development of an immunochromatographic strip test for rapid detection of a potent neutralizing anti-interferon gamma antibody in adult-onset immunodeficiency. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-08-14 Umpa Yasamut,Weeraya Thongkum,Ekkarat Wongsawat,Chatchai Tayapiwatana
BACKGROUND Adult-onset immunodeficiency (AOID) is associated with the presence of anti-interferon gamma autoantibodies (anti-IFN-γ autoAbs), which neutralizes IFN-γ signaling and leads to susceptibility to intracellular opportunistic infections. However, measuring neutralizing autoAbs is not practical for general clinical laboratories. OBJECTIVE This study aims to develop a competitive immunochromatographic
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Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-08-14 Wanying Zhai,Rui Tang,Yali Gao,Huilin Su,Hongjing Mao,Wenhui Liu,Suiting Ao,Jiande Han,Fang Wang
BACKGROUND Negative emotions are a major comorbidity of atopic dermatitis (AD). Evidence that supports the effectiveness of digital cognitive behavioral therapy (dCBT) as an adjuvant therapy for AD remains limited. OBJECTIVE To investigate the preliminary efficacy of additional dCBT and potential neurotransmitter biomarkers for AD accompanied by negative emotions. METHODS Thirty-two patients with AD
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Combined effect of hygienic and polygenic risk scores in children with allergic rhinitis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-07-16 Eom Ji Choi,Kun Baek Song,Eun Young Baek,Min Ji Park,Jisun Yoon,Sungsu Jung,Si Hyeon Lee,Mi-Jin Kang,Hea Young Oh,So-Yeon Lee,Kang Seo Park,Soo-Jong Hong
BACKGROUND Although the development of allergic rhinitis (AR) is associated with multiple genetic and hygienic environmental factors, previous studies have focused mostly on the effect of a single factor on the development of AR. OBJECTIVE This study aimed to investigate the combined effect of multiple genetic and hygienic environmental risk factors on AR development in school children. METHODS We
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Effects of a new amino acid, rice glucose polymer-based, and commercial amino acid-based formulas on growth and protein status of infants with cow's milk protein allergy. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-07-16 Narumon Densupsoontorn,Pipop Jirapinyo,Hathaichanok Rukprayoon,Supawan Kunnangja,Kwanjai Chotipanang,Punchama Pacharn,Patcharapa Thaweekul,Sira Nanthapisal
BACKGROUND Infants with cow's milk protein allergy (CMPA) are at risk for nutrient inadequacy and impaired growth. OBJECTIVE To evaluate the effect of a new amino acid-based formula (nAAF) compared with commercial amino acid-based formula (cAAF) on growth and protein status of cow's milk protein (CMP)-allergic infants and to compare their growth with those of healthy infants. METHODS Infants less than
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Prevalence and characteristics of adult patients with adult-onset and childhood-onset food allergy. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-07-16 Mongkhon Sompornrattanaphan,Suppachok Ajalasaereewong,Chamard Wongsa,Torpong Thongngarm,Piyaporn Chokevittaya,Irin Vichara-Anont,Kanyada Sirimaskasem,Jarujit Surapinij,Jomgriditip Laomoleethron,Sorawit Wihakhaphirom,Sirapat Haridravedh,Supassorn Limpiyakorn,Teerapat Paringkarn,Thanachit Krikeerati
BACKGROUND IgE-mediated food allergy (FA) affects health-related quality of life, and may cause life-threatening reactions. Few studies characterizing adult FA patients have been reported, especially first ever reaction (FER) in adult-onset. OBJECTIVE We describe the characteristics of adult FA patients, especially FER and compare these characteristics between childhood- and adult-onset FA. METHODS
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Gene expression profiles of mRNA, lncRNA, miRNA, and circRNA and their clinical implications in chronic rhinosinusitis with nasal polyps. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-07-16 Hui Li,Muhan Shi,Yuxiao Wu,Shien Huang,Congli Geng,Yan Liu,Xiaopei Yuan,Zhimin Xing,Deyun Wang,Lisheng Yu,Min Wang
BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease with complex pathophysiology and therapeutic strategies. Moreover, the molecular mechanisms underlying the pathogenesis of CRSwNP are incompletely understood. OBJECTIVE This study aimed to investigate the transcriptomic characteristics, ceRNA networks, and whether these molecular markers play a role in the
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Identification of probable pectinesterase as a major allergen of pollen of the Asian white birch (Betula platyphylla) in northern China. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-07-16 Yingyang Xu,Barbara Gepp,Nina Lengger,Jia Yin,Heimo Breiteneder
BACKGROUND Pollen of the Asian white birch (Betula platyphylla) is a major source of allergens in spring in northern China, yet little research on its pollen allergens has been done so far. OBJECTIVE To analyze the B. platyphylla pollen allergen profile of patients from northern China and to identify the major pollen allergens in this patient cohort. METHODS Sera from 35 Chinese patients with birch
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Practical recommendations for home-nebulized corticosteroid use in children aged ≤ 5 years with asthma: A review and advisory group consensus. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-07-16 Chalerat Direkwattanachai,Jitladda Deerojanawong,Chalermthai Aksilp,Orathai Jirapongsananuruk,Harutai Kamalaporn,Wasu Kamchaisatian,Sorasak Lochindarat,Lina Ngamtrakulpanit,Orapan Poachanukoon,Mongkol Lao-Araya,Jamaree Teeratakulpisarn,Kanokporn Udomittipong,Mukda Vangveeravong,Kanokpan Ruangnapa,Pantipa Chatchatee
BACKGROUND Despite nebulized budesonide being identified by the Global Initiative for Asthma report as a viable alternative to inhaled corticosteroids (ICS) delivered by pressurized metered-dose inhalers (pMDIs) with spacers, practical guidance on nebulized corticosteroid use in the pediatric population remains scarce. OBJECTIVE To review the current literature and provide practical recommendations
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Determination of the number of times for reuse of hemodialysis dialyzer through macrophage responses against dialyzer-eluted protein, a proposed method. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-11 Thansita Bhunyakarnjanarat, Piyapun Prapunwatana, Khajohn Tiranathanagul, Asada Leelahavanichkul
Although the number of times dialyzer-reuse in hemodialysis is currently determined by the total volume of the dialyzer, the determination by macrophage activation using dialyzer-eluted protein might predict systemic inflammation.
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Inhibitory effect of Zingiber cassumunar Roxb. (Phlai) on nasal cytokine productions and eosinophilic recruitment in patients with allergic rhinitis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-11 Nitchanan Achararit, Phuntila Tharabenajsin, Prapasri Kulalert, Paskorn Sritipsukho, Sira Nanthapisal, Noel Pabalan, Nateetip Krishnamra, Panan Suntornsaratoon, Orapan Poachanukoon
Zingiber cassumunar Roxb. (Phlai) has been used for the treatment of allergies including allergic rhinitis (AR). Although the anti-histamine effects have been reported, assessment of nasal cytokine and eosinophil production had not been investigated.
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The ligation of CD4 molecules, expressed on monocytes by an anti-CD4 monoclonal antibody, inhibits T cell activation and monocyte mobility. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-11 Witida Laopajon, Passaworn Cheyasawan, Supansa Pata, Nuchjira Takheaw, Watchara Kasinrerk
CD4, a leukocyte surface glycoprotein, is mainly expressed on CD4+ T cells, but is also expressed on monocytes. The difference in the expression level and structure of CD4 on T cells and monocytes predicts the different functions of this molecule in both cell types. Although the function of CD4 on T cells is well characterized, little is known about that expressed on primary monocytes.
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Phase III study of Phlai capsules in the treatment of allergic rhinitis: A randomized, double-blind, placebo-controlled trial. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-11 Minh P Hoang, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Jompol Samuthpongtorn, Kajohnkiat Prasittivatechakool, Pongsakorn Tantilipikorn, Orapan Poachanukoon, Pornthep Kasemsiri, Virat Kirtsreesakul, Jesada Kanjanaumporn, Songklot Aeumjaturapat, Supinda Chusakul, Kornkiat Snidvongs
Preclinical studies demonstrated anti-inflammatory effects of Zingiber montanum (J.König) Link ex Dietr.(Phlai). However, its clinical effect on allergic rhinitis (AR) is not evident.
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Pyroptosis induced by TLR9 ligand, ODN1826, requires ROS production and caspase-11 activation in Raw264.7 cells. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-11 Matsayapan Pudla, Rattatammanoon Saengfak, Chularat Luangjindarat, Pongsak Utaisincharoen
Toll-like receptor 9 (TLR9), located in the endosomal compartment, is known to play a role in inflammation by recognizing oligonucleotides that contain CpG motive (CpG-ODN). Signaling by TLR9 leads to the production of proinflammatory cytokines and can trigger cell death.
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Phenotype characterization and biomarker evaluation in moderate to severe type 2-high asthma. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-11 Sahoko Imoto, Maho Suzukawa, Yuma Fukutomi, Nobuyuki Kobayashi, Masami Taniguchi, Takahide Nagase, Ken Ohta
There are two major pathological phenotypes of asthma, type 2 (T2)-high and T2-low asthma, which are important in determining treatment strategies. However, the characteristics and phenotypes of T2-high asthma have not yet been fully identified.
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Comorbidities & burden of disease in atopic dermatitis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-06-01 Victor Gonzalez-Uribe,Helena Vidaurri-de la Cruz,Andres Gomez-Nuñez,Jordi A Leyva-Calderon,Zaira S Mojica-Gonzalez
BACKGROUND Atopic dermatitis is associated with an increased frequency of other atopic & allergic manifestations, including asthma in 10% to 30% of cases depending on age, allergic rhinitis, food allergies, eosinophilic diseases, and allergic conjunctivitis. The comorbidities outside the atopic march are overall less frequent than in psoriasis. OBJECTIVE This review aims to demonstrate the intense
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Mucosal brushings for nasal specific IgE to predict house dust mite driven allergic rhinitis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Aneeza W Hamizan,Raquel Alvarado,Khaizurin Tajul Arifin,Farah Dayana Zahedi,Ng Chong Sian,Anna Fariza Jumaat,Salina Husain,Man Sau Wong
BACKGROUND Skin prick testing and serological identification of allergen specific immunoglobulin E (spIgE) are standard tests for allergic rhinitis but can only identify systemic responses. In contrast, nasal allergen challenge (NAC), directly assess localized nasal mucosal reactivity, but is time consuming. Identification of spIgE from nasal brushings (nasal spIgE) is an alternative technique. OBJECTIVE
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Prospective Assessment of Penicillin Allergy (PAPA): Evaluating the performance of penicillin allergy testing and post-delabelling outcomes among Hong Kong Chinese. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Tin Sum Li,Harris K S Hui,Andy Ka Chun Kan,Maegan H Y Yeung,Jane C Y Wong,Valerie Chiang,Philip Hei Li
BACKGROUND Incorrect penicillin 'allergy' labels predispose patients to adverse outcomes but are under-recognised in many Asian countries. Studies on performance and post-delabelling outcomes of penicillin allergy evaluation among Chinese remain scarce. OBJECTIVE To evaluate the diagnostic performance of allergy testing and post-delabelling outcomes among Chinese patients in a prospective penicillin
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The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Kantima Kanchanapoomi,Witchaya Srisuwatchari,Punchama Pacharn,Nualanong Visitsunthorn,Orathai Jirapongsananuruk
BACKGROUND Non-allergic rhinitis (NAR) is characterized by symptoms of nasal inflammation without allergic sensitization. The long-term outcome of NAR in children is poorly defined. OBJECTIVE To determine the natural history of childhood-onset NAR and the development of allergic rhinitis (AR) in these children. METHODS NAR patients who were followed for more than 10 years were evaluated at 3-5 years
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The use of topical nasal steroids to improve continuous positive airway pressure compliance in patients with obstructive sleep apnea: An updated systematic review and meta-analysis of randomized control trials. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Charnsiri Segsarnviriya,Mantana Prakassajjatham,Naricha Chirakalwasan,Prakobkiat Hirunwiwatkul,Busarakum Chaitusaney,Natamon Charakorn
BACKGROUND Nasal steroids are commonly prescribed to reduce nasal side effects, which are the primary cause of continuous positive airway pressure (CPAP) intolerance in obstructive sleep apnea (OSA) patients. OBJECTIVE We conducted a systematic review and meta-analysis of OSA patients to assess the effect of nasal steroids on CPAP compliance and nasal symptoms. METHODS PubMed, Scopus, Ovid, and Cochrane
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Safety of House Dust Mite Subcutaneous Immunotherapy with a rush and cluster combination protocol in the build-up phase. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Araya Yuenyongviwat,Nutchaya Jintanapanya,Pasuree Sangsupawanich,Vanlaya Koosakulchai
BACKGROUND Conventional and cluster subcutaneous immunotherapy (SCIT) are effective but may be time-consuming. Rush SCIT may offer a more convenient treatment option to patients and be of shorter duration; however, it is also associated with a higher incidence of systemic adverse reactions. Therefore, a combination of protocols between rush and cluster SCIT could have a superior risk-benefit ratio
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Human milk oligosaccharides in Chinese lactating mothers and relationship with allergy development in offspring. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Yehao Chen,Amber Jiachi Chiou,Agnes Sze Yin Leung,Kate Ching Ching Chan,Mei Kam Chang,Nam Sze Cheng,Paul Kay Sheung Chan,Man Sau Wong,Wing Hung Tam,Ting Fan Leung
BACKGROUND The health benefits of breastfeeding are partly contributed by human milk oligosaccharides (HMOs), but there is limited data on breast milk (BM) HMO composition in Chinese. OBJECTIVE This study investigated the association between early-life HMO intake and allergy occurrence in Chinese children. METHODS 103 healthy Chinese pregnant women regardless of allergy history were recruited into
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Efficacy and safety of low- and high-dose slow oral egg immunotherapy for hen's egg allergy: Single-center non-inferiority randomized trial. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-04-17 Yuri Takaoka,Yoichi M Ito,Junko Kumon,Tomohiro Yamaguchi,Rumi Ueno,Yuki Tsurinaga,Tamana Nakano,Yohei Fukasawa,Amane Shigekawa,Yukinori Yoshida,Makoto Kameda,Satoru Doi
BACKGROUND Low-dose oral immunotherapy (OIT) is a safe treatment for hen's egg allergy; however, comparison of its therapeutic effects with those of high-dose OIT has not been reported. OBJECTIVE To compare the efficacy of low- and high-dose boiled egg-white (EW) OIT for hen's egg allergy. METHODS Patients with hen's egg allergy were randomly assigned to two groups: OIT using hard-boiled EW with a
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Prevalence of concomitant angioedema in chronic spontaneous urticaria: A systematic review and meta-analysis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-4-9 Puncharas Weerasubpong, Sukhum Jiamton, Phumithep Phumariyapong, Patompong Ungprasert, Kanokvalai Kulthanan
Angioedema (AE) is a condition associated with considerable morbidity and mortality that can significantly affect quality of life. AE often occurs in patients with CSU although the true prevalence remains unknown. Therefore, we conducted this systematic review and meta-analysis to summarize the available data.
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Chikungunya vaccines: An update in 2023. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-4-9 Pitchapa Roongaraya, Siwaporn Boonyasuppayakorn
A recent chikungunya outbreak affected 1.5 million cases in more than 60 countries. The virus causes low mortality but moderate to severe morbidities such as high fever, myalgia, and polyarthritis. The chikungunya virus is transmitted by Aedes spp. mosquitoes, of which the population has increased due to urbanization and global warming. Currently, no commercial vaccine is available, but several candidates
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Humoral and cellular immune responses against SARS-CoV-2 variants of concern induced by heterologous CoronaVac/ChAdOx-1 versus homologous ChAdOx-1 vaccination in the elderly. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-02-11 Chalerm Liwsrisakun, Supansa Pata, Witida Laopajon, Nuchjira Takheaw, Warawut Chaiwong, Pilaiporn Duangjit, Juthamas Inchai, Kantinan Chuensirikulchai, Passaworn Cheyasawan, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Watchara Kasinrerk
The concept of heterologous vaccination against SARS-CoV-2 infection has been adopted in Thailand with limited data on the induction of humoral and cellular immunity, particularly the CoronaVac/ChAdOx-1 (CoVac/ChAd) regimen in the elderly.
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Children with wheat anaphylaxis and with low wheat specific IgE have a different IgE immunoblot pattern than those with high wheat specific IgE. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-02-11 Nuntanut Rutrakool, Surapon Piboonpocanun, Unchalee Wangthan, Witchaya Srisuwatchari, Torpong Thongngarm, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Pakit Vichyanond, Punchama Pacharn
Children with wheat anaphylaxis can present with a wide range of wheat-specific IgE (sIgE).
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Perioperative immediate hypersensitivity incidence, clinical characteristics, and outcomes after allergological evaluation: A multi-disciplinary protocol from tertiary hospital, Thailand. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-02-11 Thanachit Krikeerati, Chamard Wongsa, Torpong Thongngarm, Patcharapong Rujirawan, Nutsakol Borrisut, Pattrapun Wongsripuemtet, Papapit Tuchinda, Yuttana Srinoulprasert, Chanika Subchookul, Chalisa Veerapong, Pattarapa Khunsakdeeyodom, Mongkhon Sompornrattanaphan
Perioperative immediate hypersensitivity reaction (POH) is an immediate hypersensitivity reaction during an anesthesiologist monitored procedure. We report data of clinically-suspected POH (csPOH) patients undergoing an allergist-performed unified diagnostic workup algorithm for POH.
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IgE-mediated fish allergy in Singaporean children. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-02-11 Lynette Liling Tan, May Ping Lee, Wenyin Loh, Anne Goh, Si Hui Goh, Kok Wee Chong
Fish is one of the common causes of food allergy and there is limited literature about fish allergy in Singapore.
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Skin prick test and serum specific IgE in predicting dust mite-induced allergic rhinitis diagnosed from nasal provocation test in chronic rhinitis children. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-02-11 Natchanun Klangkalya, Watcharoot Kanchongkittiphon, Adithep Sawatchai, Potjanee Kiewngam, Wanlapa Jotikasthira, Wiparat Manuyakorn
Allergen skin prick test (SPT) and serum specific immunoglobulin E (sIgE) are effective diagnostic tests in allergic rhinitis (AR), however, positive results may not always correlate with clinical allergies. A nasal provocation test (NPT) can identify the causative allergen for immunotherapy, but it's not routinely performed.
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Allergen immunotherapy for respiratory allergies in clinical practice: A comprehensive review. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-1-22 Mongkol Lao-Araya, Mongkhon Sompornrattanaphan, Dichapong Kanjanawasee, Pongsakorn Tantilipikorn
Allergen-specific immunotherapy (AIT) is the only treatment that modifies the underlying pathophysiology of IgE-mediated allergic diseases. Evidence shows the efficacy in achieving better control of the symptoms and reduction in medication use in patients with allergic rhinoconjunctivitis and/or asthma. It should be used in association with proper pharmacotherapy for at least three years. The benefits
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The relationship between outdoor air pollutants and atopic dermatitis of adults: A systematic review and meta-analysis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-1-22 Yu-Yu Hsiao, Yi-Hsing Chen, Wei-Ting Hung, Kuo-Tung Tang
Atopic dermatitis (AD) poses a significant disease burden in adults. Environmental factors are essential in its pathogenesis.
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Adult IgE-mediated food allergy is on the rise: A review of phenotypes, pathophysiologic mechanisms, diagnosis, and advances in management. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-1-22 Chanita Unhapipatpong, Narachai Julanon, Thanachit Krikeerati, Irin Vichara-Anont, Mongkhon Sompornrattanaphan
The prevalence of adult food allergies is increasing worldwide. Many aspects of food allergy in adulthood are different from childhood. We review the current evidence on adult food allergy regarding the global prevalence, adult phenotypes, cofactors, diagnostic methods, and management. A high proportion of severe reactions and unique phenotypes in adults have been characterized. Individual comorbidities
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Binding and neutralizing antibody levels and vaccine efficacy/effectiveness compared between heterologous and homologous primary series COVID-19 vaccination: A systematic review and meta-analysis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-1-22 Nasikarn Angkasekwinai, Juthamas Prawjaeng, Pattara Leelahavarong, Sarayuth Khuntha, Chatkamol Pheerapanyawaranun, Natthakan Chitpim, Varalak Srinonprasert, Kulkanya Chokephaibulkit
The data on the immunogenicity and efficacy of heterologous primary series COVID-19 vaccination are still limited.
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Did variants in inborn errors of immunity genes contribute to the extinction of Neanderthals? Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-1-22 Zijun Zhou, Sigrid M A Swagemakers, Mirthe S Lourens, Narissara Suratannon, Peter J van der Spek, Virgil A S H Dalm, Willem A Dik, Hanna IJspeert, P Martin van Hagen
Neanderthals were a species of archaic humans that became extinct around 40,000 years ago. Modern humans have inherited 1-6% of Neanderthal DNA as a result of interbreeding. These inherited Neanderthal genes have paradoxical influences, while some can provide protection to viral infections, some others are associated with autoimmune/auto-inflammatory diseases.
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The validity and reliability of a Thai version of the Angioedema Control Test: Which recall period is preferable? Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-01-03 Leena Chularojanamontri, Kanokvalai Kulthanan, Papapit Tuchinda, Chuda Rujitharanawong, Kanyalak Munprom, Oraya Pochanapan, Waratchaya Panjapakkul, Marcus Maurer, Karsten Weller
The Angioedema Control Test (AECT) is a questionnaire that monitors disease control in patients with angioedema, with a recall period of 4 weeks (AECT-4wk) or 3 months (AECT-3mo).
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COVID-19 Vaccine Allergy Safety Track (VAS-Track) pathway: real-world outcomes on vaccination rates and antibody protection. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-01-03 Valerie Chiang, Kelvin Kai Wang To, Ivan Fan Ngai Hung, Chinmoy Saha, Jackie Sh Yim, Jane Chi Yan Wong, Elaine Yl Au, Tik Suet Chan, Andy Ka Chun Kan, Yuh Dong Hong, Jiaxi Ye, Carmen S Ng, Carmen Tk Ho, Chak Sing Lau, Tommy Ty Lam, Esther Wy Chan, Jianchao Quan, Philip Hei Li
Misdiagnosed vaccine-related "allergies" lead to unnecessary vaccine deferrals and incomplete vaccinations, leaving patients unprotected against COVID-19. To overcome limitations and queues for Allergist assessment, the "VAS-Track" pathway was developed to evaluate patients via a multi-disciplinary triage model including nurses, non-specialists, and Allergists.
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Humoral SARS-CoV-2 immunogenicity wanes 3 months after heterologous inactivated vaccine followed by ChAdOx1 nCoV-19 in autoimmune rheumatic diseases. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-01-03 Parichat Uea-Areewongsa, Nawamin Pinpathomrat, Jomkwan Ongarj, Ratchanon Sophonmanee, Purilap Seepathomnarong, Bunya Seeyankem, Smonrapat Surasombatpattana, Porntip Intapiboon
Alongside vaccine hesitancy, impaired and waning immunity in autoimmune rheumatic diseases (ARDs) are barriers to immunization. The timeframe of immunity waning in ARD remains unclear.
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The association between MTHFR polymorphism, dietary methyl donors, and childhood asthma and atopy. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-01-03 Yean Jung Choi, So-Yeon Lee, Sung-Ok Kwon, Mi-Jin Kang, Ju-Hee Seo, Jisun Yoon, Hyun-Ju Cho, Sungsu Jung, Soo-Jong Hong
Studies investigating the genetic association of the C677T methylenetetrahydrofolate reductase (MTHFR) genotype and dietary methyl donors with asthma and atopy are limited, and have variable results.
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Improving cytokine-induced killer cell expansion using a gas-permeable culture method for clinical-scale production. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2023-01-03 Supannikar Tawinwung, Suparat Tudsamran, Rattapoom Thaiwong, Thiti Asawapanumas, Kitsada Wudhikarn, Chantiya Chanswangphuwana, Nattiya Hirankarn, Udomsak Bunworasate, Koramit Suppipat
Cytokine-induced killer (CIK) cells are a heterogeneous group of immune cells that exert potent MHC-unrestricted cytotoxicity toward various cancer cells in both solid and hematological malignancies.
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House dust mite allergen immunotherapy for monosensitized versus polysensitized patients with allergic rhinitis: A systematic review and meta-analysis. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-12-01 Phichayut Phinyo,Thanachit Krikeerati,Pakpoom Wongyikul,Mongkol Lao-Araya,Torpong Thongngarm
BACKGROUND Most patients with allergic rhinitis are polysensitized. The efficacy of house dust mite (HDM) allergen immunotherapy (AIT) compared between monosensitized and polysensitized patients remains limited. OBJECTIVE To systematically review the efficacy and safety of HDM AIT compared between monosensitized and polysensitized patients with allergic rhinitis. METHODS We searched PubMed/MEDLINE
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An online survey of clinical practice for allergic rhinitis among the Asia-Pacific representatives. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-10-18 Ming Zheng,Xiangdong Wang,Amir Hamzah Abdul Latiff,Ashok Shah,Duy Le Pham,Dong Young Kim,Jae Won Oh,Jiu Yao Wang,Kiat Ruxrungtham,Marysia Recto,Niken Lestari Poerbonegoro,Narantsetseg Logi,Sonomjamts Munkhbayarlakh,Ting Fan Leung,Takeshi Shimizu,Wen Chin Chiang,Wasu Kamchaisatian,Ruby Pawankar,Luo Zhang
BACKGROUND Physicians' knowledge and practice which are consistent with evidence-based guidelines can improve allergic rhinitis (AR) patients' care. Compared with western countries, the available literature about Asian doctors' perceptions and clinical practices regarding Allergic Rhinitis and its Impacts on Asthma (ARIA) guidelines is limited. OBJECTIVE To collect detailed information about the practical
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Real-life efficacy and drug continuation of secukinumab in treating moderate to severe plaque psoriasis in Aegean region of Turkey: a multicenter retrospective study and systematic review of the literature. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-10-18 Nida Kaçar,Didem Didar Balcı,Sinan Doğan,Meltem Türkmen,Melis Gönülal,Gökhan Çınar
BACKGROUND Secukinumab was demonstrated to be efficient in the treatment of moderate to severe plaque psoriasis in the phase studies. Real-life treatment experiences obtained from patients that do not meet the inclusion criteria of phase studies can provide valuable information on efficacy and safety results. Results may also differ in different ethnic populations. OBJECTIVE To investigate short and
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NLRP12 attenuates tumor necrosis factor-α production in Burkholderia pseudomallei-infected RAW264.7 macrophages. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-10-18 Matsayapan Pudla,Poramed Onsoi,Pongsak Utaisincharoen
BACKGROUND NLRP12 has been shown to play an essential role as a negative regulator in several bacterial infection. OBJECTIVE The purpose of this study is to elucidate the role of NLRP12 in B. pseudomallei-infected RAW264.7 macrophages. METHODS The protein expression and the level of TNF-α production were determined by immunoblotting and ELISA assay, respectively. RESULTS The results demonstrated that
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Disease activity of patients with chronic urticaria receiving COVID-19 vaccines. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-10-18 Papapit Tuchinda,Kanokvalai Kulthanan,Leena Chularojanamontri,Bawonpak Pongkittilar,Oraya Pochanapan,Chuda Rujitharanawong
BACKGROUND Cutaneous adverse events after receiving a COVID-19 vaccine were identified. The disease activity of urticaria after a COVID-19 vaccine has never been explored in chronic urticaria patients. OBJECTIVE To evaluate disease activity of chronic urticaria after receiving a COVID-19 vaccine. METHODS A prospective cross-sectional study was conducted in chronic urticaria patients aged 18 or above
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Bosentan versus nifedipine in the treatment of vasculopathy in systemic sclerosis patients: A randomized control trial. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-10-18 Trinh Ngoc Phat,Vu Huy Luong,Vu Nguyet Minh,Le Huyen My,Hoang Thi Phuong,Nguyen Thi Ha Vinh,Le Huu Doanh
BACKGROUND Bosentan is effective agent in scleroderma vasculopathy. However, there are no studies evaluating effectiveness of bosentan in Vietnamese patients, where nifedipine is still the common treatment. OBJECTIVE To compare the efficacy of bosentan versus nifedipine in scleroderma vasculopathy in Vietnamese patients. METHODS We randomly assigned 70 patients in a 2:1 ratio to receive oral bosentan
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Efficacy of antimalarial agents to prevent the progression of discoid lupus erythematosus to systemic lupus erythematosus: A retrospective cross-sectional study. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-08-22 Thanaporn Puaratanaarunkon, Stephen J Kerr, Pawinee Rerknimitr
Discoid Lupus Erythematosus (DLE) patients have the potential to developing Systemic Lupus Erythematosus (SLE) at a later time. The prescription of antimalarial agents might be beneficial to prevent this progression but the validated data is still lacking.
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Oleuropein attenuates inflammation and regulates immune responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-08-22 Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Jane C-J Chao, Chun-Hsun Huang, Shu-Ju Wu
Olive (Olea europaea Linn) leaves contain a phenolic compound oleuropein (Ole) has antioxidant, anti-inflammatory, and immunomodulatory activities. However, whether Ole might be an effective treatment for atopic dermatitis (AD) remains unknown.
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Systemic absorption of epinephrine compared between the intranasal and intramuscular routes of administration in healthy adults. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-08-22 Chatchawan Srisawat, Rattana Pipitpreecha, Weerawadee Chandranipapongse, Piyapat Pongnarin, Supornchai Kongpatanakul, Apirom Laocharoenkiat, Orathai Jirapongsananuruk, Nualanong Visitsuntorn, Pakit Vichyanond
Epinephrine 5 mg administered via the intranasal (IN) route was shown to be bioequivalent to epinephrine 0.3 mg administered via the intramuscular (IM) route in our preliminary study.
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Expression of ASC splice variant found in Japanese patients with palindromic rheumatism is regulated by rs8056505 single nucleotide polymorphism and interleukin-1 beta. Asian Pac. J. Allergy Immunol. (IF 5.0) Pub Date : 2022-08-22 Masaya Hattori, Atsuko Yabuuchi, Hayate Tanaka, Taketo Kawara, Hongyan Wang, Koji Inoue, Shunichi Shiozawa, Koichiro Komai
Palindromic rheumatism (PR) is an infrequent form of periodic arthritis. Based on the similarity of the pathogenesis of PR to autoinflammatory syndromes, we previously found that the dominant-active splice variant of the inflammasome adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which lacks exon 2 (Δexon2), is expressed in Japanese patients with PR.