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SARS-CoV-2: Remarks on the COVID-19 Pandemic Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-11-13 Egbert Piasecki
The COVID-19 pandemic developing rapidly in 2020 is triggered by the emergence of a new human virus—SARS-CoV-2. The emergence of a new virus is not an unexpected phenomenon and has been predicted for many years. Since the virus has spread all over the world, it will be very difficult or even impossible to eradicate it. A necessary condition for complete or partial elimination of the virus is to have
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Immune Checkpoint Blockade in Cancer Immunotherapy: Mechanisms, Clinical Outcomes, and Safety Profiles of PD-1/PD-L1 Inhibitors Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-11-13 Yan Yan, Li Zhang, Yun Zuo, Heya Qian, Chang Liu
Programmed cell death protein 1 (PD-1) and its ligand PD-L1 are critical for the regulation of T cell exhaustion and activity suppression. Tumor cells expressing immune checkpoints including PD-L1 escape monitoring of T cells from the host immune system. Checkpoint inhibitors are highly promising therapies that function as tumor-suppressing factors via modulation of tumor cell–immune cell interactions
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The Application of CAR-T Cells in Haematological Malignancies Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-11-06 Katarzyna Skorka, Katarzyna Ostapinska, Aneta Malesa, Krzysztof Giannopoulos
Chimeric antigen receptor (CAR)-T cells (CART) remain one of the most advanced and promising forms of adoptive T-cell immunotherapy. CART represent autologous, genetically engineered T lymphocytes expressing CAR, i.e. fusion proteins that combine components and features of T cells as well as antibodies providing their more effective and direct anti-tumour effect. The technology of CART construction
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Astragaloside IV Exerts Anti-tumor Effect on Murine Colorectal Cancer by Re-educating Tumor-Associated Macrophage Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-10-23 Feng Liu, Fang Ran, Hongqin He, Linyun Chen
Astragaloside IV (AS-IV) has shown anti-tumorigenic properties in certain cancers for its effect of boosting the body’s immune system, but its role in colorectal cancer (CRC) remains unclear. In this study, we investigated the therapeutic effect of AS-IV in CRC and explored its underlying mechanism. CT26 colon cancer cells and mouse model by injection of CT26 cells subcutaneously were used as in vitro
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A Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-10-13 Wioletta Ratajczak-Wrona, Natalia Wawrusiewicz-Kurylonek, Marzena Garley, Adam Jacek Kretowski, Ewa Jablonska
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily that was first identified as a factor favoring tumorigenesis. APRIL is important fitness and survival factors for B cells and plasma cells in the periphery. Considering this, as well as the quantitative predominance of neutrophils among the peripheral blood leukocytes, we carried out the first study assessing
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In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-10-04 Theodoros Eleftheriadis, Georgios Pissas, Athanasios Mavropoulos, Evdokia Nikolaou, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis
Hypoxia-inducible factor (HIF) prolyl-hydroxylase inhibitors are currently used for the treatment of renal anemia. Since HIF affects immune cells, we evaluated the effect of such a drug, the roxadustat, on adaptive immunity. Cell proliferation was assessed in a two-way mixed lymphocyte reaction (MLR) with BrdU assay. In CD4+ T cells isolated from the two-way MLRs, western blotting was performed to
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Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-09-22 Katarzyna Donskow-Łysoniewska,Katarzyna Krawczak,Maja Machcińska,Klaudia Brodaczewska
An effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings indicate that previous, subsequent or concurrent intestinal nematode infection affects the formation
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Pattern Recognition Receptors: Significance of Expression in the Liver. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-09-17 Jan Żeromski,Agata Kierepa,Bartosz Brzezicha,Arleta Kowala-Piaskowska,Iwona Mozer-Lisewska
Pattern recognition receptors (PRRs) are a pivotal part of the immune system. They are distributed in almost every site of higher organisms, able to recognize foreign pathogens or unwanted remnants of metabolism and mount innate immune response. Moreover, PRRs create bridging signaling to initiate adaptive immunity. The liver being the largest organ of the body, exposed to myriads of foreign substances
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IL-6 Contributes to the TGF-β1-Mediated Epithelial to Mesenchymal Transition in Human Salivary Gland Epithelial Cells. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-09-10 Margherita Sisto,Roberto Tamma,Domenico Ribatti,Sabrina Lisi
To determine the role of IL-6 in bringing about the EMT, in SGEC obtained from healthy subjects. Human salivary gland (SGs) epithelial cells (SGEC) from primary Sjögren’s syndrome (pSS) are able to synthesize interleukin (IL)-6, which is a critical mediator of the SGs modifications in response to chronic inflammation. Recently, a hypothetical link between epithelial-mesenchymal transition (EMT)-dependent
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Gene Expression Profiling Studies Using Microarray in Osteoarthritis: Genes in Common and Different Conditions. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-09-10 Weidong Liu,Yan Jiao,Cheng Tian,Karen Hasty,Lijie Song,Derek M Kelly,Jianwei Li,Hong Chen,Weikuan Gu,Songjiang Liu
Osteoarthritis (OA), which is characterized mainly by cartilage degradation, is the most prevalent joint disorder worldwide. Although OA is identified as a major cause of joint pain, disability, and socioeconomic burden, the etiology of OA is still not clearly known. Recently, gene microarray analysis has become an efficient method for the research of complex diseases and has been employed to determine
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The expression of bitter taste receptor TAS2R38 in patients with chronic rhinosinusitis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-09-10 Karolina Zborowska-Piskadło,Małgorzata Stachowiak,Natalia Rusetska,Elżbieta Sarnowska,Janusz Siedlecki,Karolina Dżaman
Chronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial pathogenesis. Recently, the bitter taste receptor TAS2R38 has been described to play a role in upper airway innate mucosal defense. The aim was to determine the localization and expression of the TAS2R38 in the selected cell lines and tissue collected from patient suffered from CRS as well as to correlate
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Cathepsin G and its Dichotomous Role in Modulating Levels of MHC Class I Molecules. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-08-19 Timo Burster,Uwe Knippschild,Ferdinand Molnár,Anuar Zhanapiya
Cathepsin G (CatG) is involved in controlling numerous processes of the innate and adaptive immune system. These features include the proteolytic activity of CatG and play a pivotal role in alteration of chemokines as well as cytokines, clearance of exogenous and internalized pathogens, platelet activation, apoptosis, and antigen processing. This is in contrast to the capability of CatG acting in a
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Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-08-19 Joanna Wielińska,Katarzyna Kolossa,Jerzy Świerkot,Marta Dratwa,Milena Iwaszko,Bartosz Bugaj,Barbara Wysoczańska,Monika Chaszczewska-Markowska,Sławomir Jeka,Katarzyna Bogunia-Kubik
Inconsistency of the results regarding the genetic variability within genes coding for receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) in rheumatoid arthritis (RA) prompted us to study the RANK and RANKL polymorphisms as potential biomarkers associated with disease predisposition and response to anti-TNF treatment in a group of Polish patients with RA. This study enrolled 318
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Activity-Based Protein Profiling of Serine Proteases in Immune Cells. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-08-19 Jan Pascal Kahler,Roeland Vanhoutte,Steven H L Verhelst
Multiple types of immune cells utilize serine proteases in their mechanisms of defense against pathogens or altered host cells. Dysregulation of the serine protease activity from these cells underlies different diseases. In the past, the technique of activity-based protein profiling proved to be especially useful for the study of proteases, and various studies have used small-molecule activity-based
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Professor Elwira Lisowska Celebrates Her 90th Birthday : AITE Editor (1975-1980), Member of AITE Advisory Board (1980-2016). Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-07-12 Hubert Krotkiewski,Marcin Czerwinski,Ewa Jaskiewicz,Kazimiera Wasniowska,Radoslaw Kaczmarek
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A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-06-16 Bert A 't Hart
Using a non-human primate model of the autoimmune neuroinflammatory disease multiple sclerosis (MS), we have unraveled the role of B cells in the making and breaking of immune tolerance against central nervous system myelin. It is discussed here that B cells prevent the activation of strongly pathogenic T cells present in the naïve repertoire, which are directed against the immunodominant myelin antigen
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Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-06-12 Michał Janyst,Beata Kaleta,Karolina Janyst,Radosław Zagożdżon,Ewa Kozlowska,Witold Lasek
T regulatory (Treg) cells play a critical role in the maintenance of self-tolerance, as well as in inhibition of inflammation and exaggerated immune response against exogenous antigens. They develop in the thymus (tTreg cells) but also may be generated at the peripheral tissues, including tumor microenvironment (pTreg cells), or induced in vitro in the presence of transforming growth factor (TGF)-β
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Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-06-01 Ahmed Uosef,Nicole Vaughn,Xiufeng Chu,Mahmoud Elshawwaf,Ahmed Adel Abbas Abdelshafy,Kamal Mamdoh Kamal Elsaid,Rafik Mark Ghobrial,Malgorzata Kloc
The Siponimod (Mayzent) is a newly developed drug, similar to Fingolimod (FTY720) but with fewer side effects, approved by the Food and Drug Administration for the treatment of multiple sclerosis (MS). The therapeutic effect of siponimod and FTY720 in MS relies on their inhibitory effect on the sphingosine 1-phosphate (S1P) signaling. These drugs bind to the S1P receptors and block the CCL2 chemokine
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WNT7A Expression is Downregulated in T Lymphocytes after T-Cell Receptor Activation Due to Histone Modifications and in T-ALL by DNA Methylation. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-05-26 Christian Barreto-Vargas,Monserrat Alvarez-Zavala,Mariel Garcia-Chagollan,Georgina Hernandez-Flores,Adriana Aguilar-Lemarroy,Luis F Jave-Suarez
WNT signaling pathway regulates several processes involved in the homeostasis of normal cells. Its dysregulation is associated with pathological outcomes like cancer. We previously demonstrated that downregulation of WNT7A correlates with higher proliferation rates in acute lymphoblastic leukemia. However, the regulation of this gene in pathological and normal conditions remains unexplored. In this
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Exopolysaccharide from Lactobacillus rhamnosus KL37 Inhibits T Cell-dependent Immune Response in Mice. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-05-25 Bernadeta Nowak,Małgorzata Śróttek,Marta Ciszek-Lenda,Anna Skałkowska,Andrzej Gamian,Sabina Górska,Janusz Marcinkiewicz
Exopolysaccharides (EPSs), major components of the bacterial biofilm, display strong strain-specific immunomodulatory properties. Previously, we have shown that crude EPS derived from Lactobacillus rhamnosus KL37 depresses the production of arthritogenic anti-collagen IgG and ameliorates collagen-induced arthritis (CIA) in DBA/1 mice, when lipopolysaccharide (LPS) was used as adjuvant. In this study
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Decreased Serum Adiponectin Reflects Low Vitamin D, High Interleukin 6, and Poor Physical Performance in Knee Osteoarthritis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-05-24 Wanvisa Udomsinprasert,Pacharee Manoy,Pongsak Yuktanandana,Aree Tanavalee,Wilai Anomasiri,Sittisak Honsawek
Obesity is a major contributor to deterioration of physical function toward sarcopenia in knee osteoarthritis (OA) due to its effect mediated through adipokines-derived molecules that have pro-/anti-inflammatory properties. This study aimed to investigate relationships of serum adiponectin, 25-hydroxyvitamin D (25(OH)D), interleukin (IL)-6, and physical performance in knee OA patients. A total of 175
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BW5147 and Derivatives for the Study of T Cells and their Antigen Receptors. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-05-18 Janice White,Rebecca L O'Brien,Willi K Born
Like B cells, T cells can be immortalized through hybridization with lymphoma cells, a technique that has been particularly useful in the study of the T cell receptors (TCR) for antigen. In T cell hybridizations, the AKR mouse strain-derived thymus lymphoma BW5147 is by far the most popular fusion line. However, the full potential of this technology had to await inactivation of the productively rearranged
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HLA-A and -B Type and Haplotype Frequencies in IgG Subclass Deficiency Subgroups. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-20 James C Barton,Jackson C Barton,Luigi F Bertoli,Ronald T Acton
We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal IgG1/IgG3) and controls (1,321 for types; 751 for haplotypes). We selected types and
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Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-15 Paulina Niedźwiedzka-Rystwej,Mikołaj Wołącewicz,Piotr Cywoniuk,Marta Klak,Michał Wszoła
Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being
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Specific T-Cell Subsets Can Predict the Efficacy of Anti-TNF Treatment in Inflammatory Bowel Diseases. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-04 Sonja Dulic,Gergely Toldi,Florentina Sava,László Kovács,Tamás Molnár,Ágnes Milassin,Klaudia Farkas,Mariann Rutka,Attila Balog
The effect of TNF-blockers on T-lymphocyte subsets is largely unknown in inflammatory bowel diseases (IBDs). The aim of the present study was to analyze the prevalence of T-cell subtypes and their correlation to therapeutic response. Sixty-eight patients with Crohn's disease (CD), 46 with ulcerative colitis (UC) were enrolled. (1) The clinical course was followed after the initiation of TNF-blockers
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Antibodies to Heat Shock Proteins 90α and 90β in Psoriasis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-01 Aleksandra Damasiewicz-Bodzek,Magdalena Szumska,Krystyna Tyrpień-Golder
One of many hypotheses of psoriasis pathogenesis supposes an overexpression of heat shock proteins (Hsps) in different skin layers and systemic immunologic response to them. Hsp90 is one of the most abundant chaperone in eukaryotic cells. The number of studies concerning the role of Hsp90 and anti-Hsp90 antibodies in etiopathogenesis of various diseases is also constantly expanding. Still, there are
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Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-01 Seyede Sara Seyedizade,Khashayar Afshari,Saba Bayat,Fatemeh Rahmani,Saeideh Momtaz,Nima Rezaei,Amir Hossein Abdolghaffari
Chronic inflammation of the gastrointestinal system is mediated by both the immune system activity and homeostasis, mainly through releasing of various cytokines and chemokines, as well as the transmigration of the inflammatory cells to the affected site. In between, macrophages are key mediators of the immune system, nearly located all over the gastrointestinal tract. Macrophages have vital influence
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Food Allergy Insights: A Changing Landscape. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-01 Massimo De Martinis,Maria Maddalena Sirufo,Angelo Viscido,Lia Ginaldi
The panorama of food allergies (FA) has changed profoundly in recent years. In light of recent advances in knowledge of pathogenetic mechanisms and a greater attention to the multifaceted range of possible clinical manifestations, there is a need for a critical review of past classifications. Changes in nutrition, environment and lifestyles around the world are modifying the global FA epidemiology
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In Vitro Immunological Effects of CXCR3 Inhibitor AMG487 on Dendritic Cells. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-04-01 Chenchen Qin,Huihui Liu,Bo Tang,Min Cao,Zhengyu Yu,Beichen Liu,Wei Liu,Yujun Dong,Hanyun Ren
AMG 487 is the targeted blocker of chemokine receptor CXCR3 and improves inflammatory symptoms by blocking the inflammatory cycle. Here we investigated whether AMG 487 affects dendritic cell (DC) biology and function. The expression of co-stimulatory markers on DCs was reduced, indicating the semi-mature state of DC when AMG 487 was added throughout the in vitro differentiation period. Additionally
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Correction to: Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-02-20 Wiem Chaabane, Saeid Ghavami, Andrzej Małecki, Marek J. Łos
The authors would like to correct the following error.
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Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-02-19 Shenling Li,Xiaotian Zhang,Zhiyuan Li,Xiaodan Jiang,Niankai Zhang,Jisheng Zhang,Yichuan Huang,Han Zhao,Yan Jiang,Na Li
Allergic rhinitis (AR) is an IgE-mediated inflammation which causes olfactory dysfunction. Antihistamines have been widely used to treat AR while few studies have investigated the effect of antihistamines on improving the sense of smell. In addition, the underlying mechanisms are not well elucidated. We established the ovalbumin (OVA)-induced allergic rhinitis rat model and administrated desloratadine
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Autotransplantation of the Adipose Tissue-Derived Mesenchymal Stromal Cells in Therapy of Venous Stasis Ulcers. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-02-14 Leszek Masłowski,Maria Paprocka,Agnieszka Czyżewska-Buczyńska,Aleksandra Bielawska-Pohl,Danuta Duś,Ryszard Grendziak,Wojciech Witkiewicz,Anna Czarnecka
Adipose tissue is a reliable source of mesenchymal stromal cells (MSC) for use in regenerative medicine. The aim of this pilot study was to describe the method, and assess the safety and the potential efficacy of transplantation of autologous adipose tissue-derived MSC for the treatment of chronic venous stasis ulcers. Study group consisted of 11 patients (mean age: 66.6 ± 9.5 years) with chronic venous
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Can Interferon-γ Release Assays Be Useful for Monitoring the Response to Anti-tuberculosis Treatment?: A Systematic Review and Meta-analysis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-02-03 Babak Pourakbari,Setareh Mamishi,Sepideh Benvari,Ilaria Sauzullo,Andrea Bedini,Piero Valentini,Naoto Keicho,Shima Mahmoudi
The number of studies which evaluated interferon-gamma release assays (IGRAs) results after anti-tuberculosis (TB) treatment has been rapidly increasing. The aim of this study was to investigate the potential use of IGRAs (QFT-GIT, T-SPOT.TB, QFT-Plus) in assessing the response to anti-TB treatment. We searched all studies in English language published from 1 October 2011 to 18 November 2018 in PubMed
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Treatment with Lycopodium clavatum 200dH Intensifies Kidney and Liver Injury in Mice Infected with Toxoplasma gondii. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-01-21 Andréia Vieira Pereira,Marcelo Biondaro Gois,Katiucha Rebeca Jennifer Lopes Lera,Milena Menegazzo Miranda-Sapla,Gislane Janaina Falkowski-Temporini,Juliana Evangelista Bezerril,Gerson Zanusso-Junior,Fabiana Nabarro Ferraz,Suelen Santos da Silva,Denise Lessa Aleixo,Ivete Conchon-Costa,Debora de Mello Gonçales Sant'Ana,Idessania Nazareth da Costa,Silvana Marques de Araújo,Wander Rogério Pavanelli
The effects of infection with Toxoplasma gondii vary from asymptomatic to the development of alterations in various organs (including the liver and kidneys) which may be irreversible, and lead to the death of the host. Whereas homeopathy is an alternative and effective method for treating various diseases, including those caused by protozoa, we questioned the effect of using Lycopodium clavatum in
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HER2-Positive Breast Cancer Immunotherapy: A Focus on Vaccine Development. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-01-09 Atefeh Arab,Rezvan Yazdian-Robati,Javad Behravan
Clinical progress in the field of HER2-positive breast cancer therapy has been dramatically improved by understanding of the immune regulatory mechanisms of tumor microenvironment. Passive immunotherapy utilizing recombinant monoclonal antibodies (mAbs), particularly trastuzumab and pertuzumab has proved to be an effective strategy in HER2-positive breast cancer treatment. However, resistance to mAb
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Type III Interferons (Lambda Interferons) in Rheumatic Autoimmune Diseases Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2020-01-09 Tania Mora-Arias, Luis M. Amezcua-Guerra
Abstract The last 2 decades have witnessed the discovery and characterization of a new family of cytokines with immunological characteristics similar to those described for type I interferons, type III or lambda interferons. Unraveling the molecular mechanisms underlying each type of interferon has allowed us to understand how some autoimmune diseases can be considered as interferonopathies. Under
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Induction of Chronic Subclinical Systemic Inflammation in Sprague-Dawley Rats Stimulated by Intermittent Bolus Injection of Lipopolysaccharide. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-07-05 Yazan Ranneh,Abdah Md Akim,Hasiah Ab Hamid,Huzwah Khazaai,Norhafizah Mokhtarrudin,Abdulmannan Fadel,Mohammed H K Albujja
Chronic subclinical systemic inflammation has a key role in stimulating several chronic conditions associated with cardiovascular diseases, cancer, rheumatoid arthritis, diabetes, and neurodegenerative diseases. Hence, developing in vivo models of chronic subclinical systemic inflammation are essential to the study of the pathophysiology and to measure the immunomodulatory agents involved. Male Sprague-Dawley
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Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-09-18 Asmaa M Zahran,Alameldin M Abdallah,Khaled Saad,Naglaa S Osman,Mervat A M Youssef,Yasser Farouk Abdel-Raheem,Khalid I Elsayh,Amir M Abo Elgheet,Sanaa F Darwish,Mohamd A Alblihed,Amira Elhoufey
Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case-control study included 20 children with JIA as well as 20 healthy children with matching age and sex as a control group. All patients included in the study were in activity as determined by visual
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Modulatory Effect of the Euro-Lupus Low-Dose Intravenous Cyclophosphamide Regimen on Circulating Immune Cells in Systemic Lupus Erythematosus. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-10-16 Gabriela Gabcova,Pavel Horak,Zuzana Mikulkova,Martina Skacelova,Sarka Zehnalova,Andrea Smrzova,Anna Petrackova,Frantisek Mrazek,Eva Kriegova
A Euro-Lupus regimen of low-dose intravenous cyclophosphamide (CFA) is commonly used to treat severe organ manifestations of systemic lupus erythematosus (SLE), particularly lupus nephritis (LN). There are no data on the distributions and dynamics of immune cell populations in patients with various treatment outcomes. The circulating immune cells of 11 female SLE patients were assessed before and after
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Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-07-19 Zbigniew Wyżewski,Karolina P Gregorczyk-Zboroch,Matylda B Mielcarska,Magdalena Bossowska-Nowicka,Justyna Struzik,Joanna Szczepanowska,Felix N Toka,Marek G Niemiałtowski,Lidia Szulc-Dąbrowska
Poxviruses utilize multiple strategies to prevent activation of extrinsic and intrinsic apoptotic pathways for successful replication. Mitochondrial heat shock proteins (mtHsps), especially Hsp60 and its cofactor Hsp10, are engaged in apoptosis regulation; however, until now, the influence of poxviruses on mtHsps has never been studied. We used highly infectious Moscow strain of ectromelia virus (ECTV)
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Gut Microbiota in Neurological Disorders. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-10-01 Marta Grochowska,Tomasz Laskus,Marek Radkowski
The incidence of neurological disorders such as multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD) is increasing throughout the world, but their pathogenesis remains unclear and successful treatment remains elusive. Bidirectional communications between the central nervous system and gut microbiota may play some role in the pathogenesis of the above disorders. Up to a thousand
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Interleukin-1 Genotype in Periodontitis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-07-19 Aniela Brodzikowska,Renata Górska,Jan Kowalski
This paper presents the current knowledge concerning the role of polymorphisms of IL1A and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the pathogenesis of the disease, and to the significance of a genetic test, investigating the presence of composite two polymorphisms of IL-1 gene, as a risk factor for severe periodontitis. The significance of this test for prevention
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Retinoids as an Immunity-modulator in Dermatology Disorders. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-09-24 Wangqing Chen,Shuang Zhao,Wu Zhu,Lisha Wu,Xiang Chen
The skin is the largest epithelial surface protecting the body from invading microbes. Vitamin A plays vital roles in the host defence of the skin, including promoting epithelial cell integrity, proliferation, and differentiation and even mediating immune responses. Furthermore, vitamin A derivatives, retinoid drugs, are widely used to treat skin diseases, such as acne and psoriasis. However, the immunoregulatory
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Correction to: Significance and Role of Pattern Recognition Receptors in Malignancy. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-08-31 Jan Żeromski,Mariusz Kaczmarek,Maciej Boruczkowski,Agata Kierepa,Arleta Kowala-Piaskowska,Iwona Mozer-Lisewska
The authors would like to correct the following error.
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Diverse Activity of IL-17+ Cells in Chronic Skin and Mucosa Graft-Versus-Host Disease. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-06-08 Aleksandra Klimczak,Krzysztof Suchnicki,Mariola Sedzimirska,Andrzej Lange
Excessive inflammatory environment in a course of chronic graft-versus-host disease (cGvHD) is associated with T-cell trafficking into inflamed tissues. This study focused on the identification of IL-17-producing cells in the tissue biopsies of cGvHD patients. Forty-one biopsy specimens of cGvHD lesions of the skin (n = 27), gastrointestinal tract (n = 9) and oral mucosa (n = 5), examined in 24 patients
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Clinical and Immunological Features of 78 Adult Patients with Primary Selective IgG Subclass Deficiencies. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-07-30 Amrita Khokar,Sudhir Gupta
The purpose of this study is to describe both clinical and immunological features in large cohort of adult patients with IgG subclass deficiency, and response to immunoglobulin therapy. This is a retrospective study of data obtained from electronic medical records and paper charts of 78 patients with IgG subclass deficiency seen and followed at our immunology clinics from 2010 to 2016. Both isolated
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Adjuvant Allergen Fusion Proteins as Novel Tools for the Treatment of Type I Allergies. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-06-20 Frank Blanco-Pérez,Garibald Papp,Alexandra Goretzki,Tobias Möller,Martina Anzaghe,Stefan Schülke
While acute allergic symptoms can be managed by emergency medication, to date, allergen-specific immunotherapy (SIT) with allergen extracts is the only available curative treatment option. However, the risk of anaphylactic reactions, long treatment duration, varying extract quality, and underrepresentation of certain allergens currently prevent many patients from successfully undergoing SIT. Novel
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90th Birthday of Prof. Czesław Radzikowski. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-09-01 Piotr Kuśnierczyk
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Role of Macrophages in Pregnancy and Related Complications. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-07-08 Manoj K Jena,Neha Nayak,Kang Chen,Nihar R Nayak
Macrophages (MФs) are the leukocytes produced from differentiation of monocytes and are located in almost all tissues of human body. They are involved in various processes, such as phagocytosis, innate and adaptive immunity, proinflammatory (M1) and anti-inflammatory (M2) activity, depending on the tissue microenvironment. They play a crucial role in pregnancy, and their dysfunction or alteration of
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CTLA-4 Expression Inversely Correlates with Kidney Function and Serum Immunoglobulin Concentration in Patients with Primary Glomerulonephritides. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-06-08 Ewelina Grywalska,Iwona Smarz-Widelska,Sebastian Mertowski,Krzysztof Gosik,Michał Mielnik,Martyna Podgajna,Monika Abramiuk,Bartłomiej Drop,Jacek Roliński,Wojciech Załuska
Major causes of chronic kidney disease are primary proliferative and nonproliferative glomerulonephritides (PGN and NPGN). However, the pathogenesis of PGN and NPGN is still not fully understood. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a T-cell membrane receptor that plays a key role in T-cell inhibition. Despite its role in autoimmunological diseases, little is known about the involvement
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Variant and Specific Forms of Autoimmune Cholestatic Liver Diseases. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-06-05 George N Dalekos,Nikolaos K Gatselis
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. IgG4-associated sclerosing cholangitis is another distinct immune-mediated cholestatic disorder of unknown aetiology that is frequently associated with autoimmune pancreatitis or other IgG4-related diseases. Although the majority of PBC and PSC patients have a typical presentation
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Proportion of Cytotoxic Peripheral Blood Natural Killer Cells and T-Cell Large Granular Lymphocytes in Recurrent Miscarriage and Repeated Implantation Failure: Case-Control Study and Meta-analysis. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-05-30 Kamila Kolanska,Ludovic Suner,Jonathan Cohen,Yasmine Ben Kraiem,Leo Placais,Olivier Fain,Marie Bornes,Lise Selleret,François Delhommeau,Frédéric Feger,Emmanuelle Mathieu d'Argent,Emile Darai,Nathalie Chabbert-Buffet,Jean-Marie Antoine,Gilles Kayem,Arsène Mekinian
We aimed to compare the proportion of peripheral blood natural killer (NK) cells (CD3-CD56+) and T-cell large granular lymphocytes (CD8+CD57+) during preconception in a homogenous group of women with unexplained well-defined recurrent miscarriage (RM) and repeated implantation failure (RIF) vs healthy controls in relation to pregnancy outcomes. This case-control study followed by a literature review
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Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-05-29 Xin-Tong Wu,Abdur Rahman Ansari,Xin-Xin Pang,Hui-Zhen Li,Zhe-Wei Zhang,You Luo,Muhammad Arshad,Hui Song
Visfatin is involved in the body's inflammation and immune response. Inflammation could promote, while visfatin may directly or indirectly mitigate the effects of apoptosis and autophagy. Whether visfatin lessens the detrimental effects of lipopolysaccharide (LPS)-induced mouse acute lung injury (ALI) is poorly understood yet. Therefore, in the current study, the regulation mechanism of visfatin on
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MicroRNAs: Potential Biomarkers and Targets of Therapy in Allergic Diseases? Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-05-28 Krzysztof Specjalski,Ewa Jassem
MicroRNAs (miRNAs) are small non-coding RNA molecules that are 18-22 nucleotides long and highly conserved throughout evolution. Currently, they are considered one of the fundamental regulatory mechanisms of genes expression. It has been demonstrated that miRNAs are involved in many biologic processes, such as signal transduction, cell proliferation and differentiation, apoptosis and stress responses
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IgG from Non-atopic Individuals Induces In Vitro IFN-γ and IL-10 Production by Human Intra-thymic γδT Cells: A Comparison with Atopic IgG and IVIg. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-05-13 Ludimila Souza Santos,Fábio da Ressureição Sgnotto,Amanda Harumi Sabô Inoue,Archangelo Fernandes Padreca,Ricardo Palamar Menghini,Alberto José da Silva Duarte,Jefferson Russo Victor
Matured in the thymus, γδT cells can modulate the development of allergy in humans. The main γδT cell subsets have been described as interleukin (IL)-17A or interferon (IFN)-γ producers, but these cells can also produce other modulatory cytokines, such as IL-4 and IL-10. Here, we aimed to evaluate whether IgG can modulate the profile of cytokine production by γδT cells during their maturation in the
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The Influence of Antidepressants on the Immune System. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-04-30 Łukasz P Szałach,Katarzyna A Lisowska,Wiesław J Cubała
Depression is one of the most frequently diagnosed condition in psychiatry. Despite the availability of many preparations, over 30% of treated patients do not achieve remission. Recently the emphasis is put on the contribution of the body's inflammatory response as one of the causes of depression. The interactions between nervous and immune systems are the main issue addressed by psychoneuroimmunology
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Post-transplant Alternative Complement Pathway Activation Influences Kidney Allograft Function. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-04-28 Dorota Bartoszek,Oktawia Mazanowska,Katarzyna Kościelska-Kasprzak,Agnieszka Lepiesza,Marta Myszka,Marcelina Żabińska,Magdalena Krajewska,Marian Klinger
The complement system is one of the crucial pathophysiological mechanisms that directly influence the function of a transplanted kidney. Since the complement pathways' activation potential can be easily determined via their functional activity measurement, we focused on fluctuation in the cascade activity in the early post-transplant period. The aim of the study was to relate the kidney transplantation-induced
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Conjugation of Meningococcal Lipooligosaccharides Through Their Non-Reducing Terminus Results in Improved Induction a Protective Immune Response. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-04-27 Małgorzata Mieszała,Harold J Jennings,Marek Drab,Andrzej Gamian
The present studies prove that conjugation of meningococcal lipooligosaccharides through their non-reducing terminus conserves their inner epitopes resulting in conjugates potent to induce a protective immune response. Four different oligosaccharides were obtained by specific degradations of the same L7 lipooligosaccharide (L7-LOS), and each was linked to tetanus toxoid by direct reductive amination
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Heterogeneous Mixture of Amniotic Cells is Likely a Better Source of Stem Cells than Adipose Tissue. Arch. Immunol. Ther. Exp. (IF 3.2) Pub Date : 2019-04-17 Diana Kitala,Agnieszka Klama-Baryła,Marcelina Misiuga,Wojciech Łabuś,Małgorzata Kraut,Michał Szapski,Marta Lesiak,Daniel Krakowian,Aleksander L Sieroń,Marek J Łos,Marek Kucharzewski
Stem cells are increasingly being used in the course of burn treatment. As several different types of stem cells are available for the purposes, it is important to chose the most efficient and the most practicable stem cell type. The aim of this study was to compare the potential of heterogeneous amnion cell mixture with the presently used standard therapy, the adipose tissue-derived stem cells. The