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EXTL3-Associated Immunoskeletal Dysplasia with Neurodevelopmental Abnormalities: A Lethal Phenotype. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-11-20 Engin Demir,Filiz Adım,Mehmet Ercüment Döğen,Ayşe Aydoğdu,Edanur Yeşil,Serdar Mermer,Burak Başer,Gizem Ürel Demir
Background: Immunoskeletal dysplasia with neurodevelopmental abnormalities (ISDNA) caused by Exostosin-Like Glycosyltransferase 3 (EXTL3) biallelic mutations is a very rare syndrome with only 16 cases reported in the literature. Skeletal dysplasia, neurodevelopmental delay, immunodeficiency, liver, and kidney cysts are the most common findings of this syndrome. Case Presentation: Here, we report on
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Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Caused by Itraconazole in a 17-Year-Old Girl. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-09-20 Helena Pires Pereira,Iolanda Alen Coutinho,Isabel Carrapatoso,Ana Todo-Bom
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe adverse drug-induced hypersensitivity reaction. We report a case of DRESS syndrome in a 17-year-old female caused by itraconazole, confirmed by patch testing, that required treatment with both corticotherapy and cyclosporine. Our case highlights the importance of clinical suspicion of this syndrome in pediatric age and the
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Assessing Available Adolescent Self-Reported Measures for Asthma Management: A Systematic Literature Review. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-09-06 Elif Isik,Gardner Mack,Marianna M Sockrider,Nina M Fredland,Ross Shegog
Objective: Asthma is a common chronic disease and a substantial public health problem for children, adolescents, and adults. Adolescence, a period of increased independence and striving for autonomy, is an opportune time for youth transitioning to adulthood to assume more responsibility for their own asthma self-management. However, accurate measures of adolescent asthma outcomes are limited. The purpose
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Application of Asthma Prediction Tools in a Cohort of Infants with Severe Bronchiolitis. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-08-28 Ronaldo C Fabiano Filho,Ruth J Geller,Ludmilla Candido Santos,Janice A Espinola,Lacey B Robinson,Carlos A Camargo
Background: Severe bronchiolitis is a strong childhood asthma risk factor. Early and accurate asthma prediction is key. We applied the Asthma Predictive Index (API), the modified Asthma Predictive Index (mAPI), and the Pediatric Asthma Risk Score (PARS) in a cohort of high-risk infants to predict asthma at age 6 years. Methods: We conducted a 17-center cohort of infants (age <1 year) hospitalized with
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Habits and Perspectives on Reading Allergy Food Labels of Parents of Children with Food Allergies. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-08-09 Selçuk Doğan,Ezgi Ulusoy Severcan,Murat Özer,Ayşegül Ertuğrul
Study Objective: Food allergy is an essential growing public health concern that affects the quality of life of children and their parents. This study aimed to identify the parents' awareness and daily practice about food labels and allergy warnings on packaged foods. Materials and Methods: The study investigated the parents of children with food allergies who applied to the pediatric allergy outpatient
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Recurrent Anaphylaxis with Watermelon and Pumpkin Seeds in a Boy Tolerant to Their Pulps. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-08-08 Tugba Guler,Ilknur Kulhas Celik,Meltem Comert,Hasibe Artac
Background: Seeds are widely consumed as a traditional snack and have rich contents beneficial to health. With an increase in consumption rates, allergic reactions occur more frequently. We focus on multiple seed consumption related to recurrent anaphylaxis in this case. Case Presentation: We evaluated an 11-year-old boy with recurrent anaphylaxis. According to his medical records, he had been hospitalized
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Comparison of Pneumotachometer and Portable Digital Turbine Spirometry for Field-Based Assessment: An Air Quality, Environment, and Respiratory Outcomes in Bronchopulmonary Dysplasia Study. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-07-31 Lana Mukharesh,Morgan Ryan,Lystra P Hayden,Suzanne E Dahlberg,Jonathan M Gaffin
Introduction: Data on the use of remote spirometry are limited in the pediatric population. We sought to assess the feasibility and accuracy of a digital turbine spirometer, Medical International Research (MIR) Spirobank Smart (MIR, New Berlin, WI, USA), compared with a pneumotachography spirometer, Pneumotrac (Vitalograph Inc., Lenexa, KS, USA), in field-based clinical research. Methods: This is a
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Kawasaki Disease Associated with SARS-CoV2 in a Pair of Triplets. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-07-19 Luisa Berenise Gamez-Gonzalez,Luis Xochihua-Díaz,Moises Ramirez-Lopez,Marcela Colmenero-Rascon,Emiy Yokoyama-Rebollar,Itzya Hernández-Santiago,Abner Bojalil-Cabildo,Marco Antonio Yamazaki-Nakashimada
The etiology of Kawasaki disease (KD) and its precise genetic basics remain unknown. Genetic variants affecting immunity have been found in some patients. The occurrence of KD in siblings is rare, but KD pedigrees with multiple affected members have been described in Japan and North America. Cases in twins have been documented. We report 2 pairs of trizygotic triplets who developed KD associated with
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Evaluation of Children with Cow's Milk Allergy Who Received Measles or Measles, Mumps, and Rubella Vaccines Containing Alpha-Lactalbumin. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-07-11 Ezgi Ulusoy Severcan,Aysegul Ertugrul,Serap Ozmen
Objective: Cases of cow's milk allergy (CMA) who reacted to measles or measles, mumps, and rubella (MMR) vaccines containing alpha-lactalbumin have been reported. The purpose of this study was to assess patients with CMA who received measles or MMR vaccines containing alpha-lactalbumin, as well as the characteristics of those who developed reactions to these vaccines. Study Design: Patients followed
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Assessing the Response of Biomarkers to Anti-Inflammatory Medications in PIMS-TS by Longitudinal Multilevel Modeling: Real-World Data from a UK Tertiary Center. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-07-11 Joseph J Tonge,Olivia Stevens,Jeremy Dawson,Daniel Hawley,Caroline Kerrison,Nils Krone,Sarah L Maltby,Anne-Marie McMahon,Fiona Shackley,Rupa Talekar,Carmen Gonzalez-Martinez,Neil Lawrence
Background: Pediatric inflammatory multisystem syndrome temporarily associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PIMS-TS) is an acute complication of previous SARS-CoV-2 exposure. The relationship between inflammatory markers and anti-inflammatory medication in PIMS-TS is unknown. We retrospectively investigated the relationship between demographics, biomarkers
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Leflunomide Is Safe and Effective for the Induction and Maintenance of Idiopathic Pulmonary Hemosiderosis Remission. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-06-02 Haiyan Wang,Rongqiong Ou,Bihong Zhang,Sha Li,Yong Liu,Weiping Tan
Objective: The present study was aimed to investigate the efficacy of leflunomide in idiopathic pulmonary hemosiderosis (IPH) disease control and glucocorticoid attenuation. Methods: The efficacy of leflunomide was determined based on disease control, safety, and glucocorticoid attenuation. Result: A total of 46 children with IPH were included in the present study. Of these 31 patients had been unsuccessfully
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Clinical Features of COVID-19 in Patients with Congenital Central Hypoventilation Syndrome. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-05-18 Ajay S Kasi,Melinda Riccitelli,Sheila S Kun,Adrianna L Westbrook,George L Silva,Thomas G Keens,Lokesh Guglani
Background: The clinical course of COVID-19 in patients with congenital central hypoventilation syndrome (CCHS) is unknown. Methods: We conducted a cross-sectional questionnaire study in 43 patients with CCHS who had COVID-19. Results: The median age of patients was 11 [interquartile range (IQR) 6-22] years and 53.5% required assisted ventilation (AV) through tracheostomy. Disease severity ranged from
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Delayed Severe Gingivitis After Placement of Orthodontic Braces in an Atopic Teenager: A Case Report and Literature Review. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-05-15 Charles W Stewart,Catherine M Hammond,Mitchel S Godat,D Betty Lew
We report a case of a 15-year-old atopic patient presenting with delayed, severe ulcerative hypertrophic gingivitis after placement of orthodontic braces, which required removal of braces and restorative laser surgical procedures. Patch testing to multiple metals and chemicals showed weak positive reactions to steel bands and formaldehyde. The patient experienced urticarial, gingivitis, and other intraoral
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Eruption of Permanent Teeth As Risk Factor for Allergic Reactions During Oral Immunotherapy. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-05-09 Francesca Mori,Benedetta Pessina,Mattia Giovannini,Giulia Liccioli,Lucrezia Sarti,Erika Paladini,Leonardo Tomei,Simona Barni
Background: Oral immunotherapy (OIT) increases the threshold of reaction in children older than 4 years with food allergy. The risk for severe allergic reactions (ARs) during OIT has been reported in several studies, often in the presence of concomitant cofactors such as physical exercise, empty stomach, medications, poorly controlled asthma, menses, and alcohol consumption. Cases Presentation: We
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New for 2022: Food and Drug Administration Approvals of Pediatric Respiratory Medications. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-05-09 Scott Bickel,Nemr Eid,Matthew Delaney,Ronald Morton
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Changes in Body Mass Index in Children and Adolescents with Asthma during the COVID-19 Pandemic. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-03-24 Christy Kim,Sankaran Krishnan,John J Welter,Kathleen Fan,Samuel Desantis,Jennifer Kim,Sheila V Krishnan,Diane Lindsay-Adler,Allen J Dozor
Background: Increased weight gain in children during the COVID-19 pandemic has been reported. Changes in weight in children with asthma during this period have not been well described. Methods: Retrospective review of children with asthma, 6-18 years of age, seen in 2019 and 2020. Mean monthly rates of change in body mass index (BMI) were compared between years. Demographic and asthma-related factors
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Neighborhood Characteristics and the Burden of E-Cigarette, or Vaping, Product Use-Associated Lung Injury: An Ecological Comparison Study. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-03-01 Harin Lee,Sitara M Weerakoon,Melissa B Harrell,Sarah E Messiah,Devika R Rao
Purpose: E-cigarette, or vaping, product use-associated lung injury (EVALI) is a severe consequence of vaping first described in 2019. Investigating associations between neighborhood-level characteristics and EVALI cases is an important step in identifying at-risk communities to implement future targeted prevention programs. Methods: We retrospectively identified 41 adolescents <19 years hospitalized
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Low Serum Vascular Endothelial Growth Factor Level Predicts Adverse Outcomes in Neonates with Respiratory Distress Syndrome. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-03-01 Qiuying Cheng,Min Xiao,Jiaolei Chen,Jianwei Ji
Objective: Preterm neonates are susceptible to neonatal respiratory distress syndrome (NRDS). Lower levels of cord blood vascular endothelial growth factor (VEGF) are implicated in NRDS. This study aims to explore whether the serum VEGF level has prognostic values on neonates with respiratory distress syndrome (RDS). Methods: A total of 80 infants diagnosed with NRDS were enrolled, with 70 preterm
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Adolescent Views on Asthma Severity and Management During the COVID-19 Pandemic. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-02-15 Carson M Collins,Amarilis Céspedes,Kayla A Diggs,Jianfang Liu,Jean-Marie Bruzzese
Background: Asthma and COVID-19 have overlapping symptoms. During the 2019-2022 pandemic, pediatric asthma control appears to have improved, with some researchers theorizing that that is due to changes in asthma self-management. This study examined adolescents' views regarding how the pandemic impacted their asthma severity and self-management. Differences by urbanicity, sex, and race/ethnicity were
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Childhood Interstitial Lung Disease Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2023-01-24 Halime Nayir Buyuksahin, Nural Kiper
Childhood interstitial lung disease (chILD) is a heterogeneous group of diseases with various clinical and imaging findings. The incidence and prevalence have increased in recent years, probably due to better comprehension of these rare diseases and increased awareness among physicians. chILDs present with nonspecific pulmonary symptoms, such as tachypnea, hypoxemia, cough, rales, and failure to thrive
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Caregiver Expressed Emotion and Pediatric Asthma: A Call for Culturally Specific Adaptations Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-27 Katherine D. Lohr, Robin S. Everhart, Jessica L. Greenlee, Marcia A. Winter
Background: Expressed emotion is the affective attitudes and behaviors of an individual toward another. In this preliminary study, we described expressed emotion among caregivers of children with asthma living in low-income urban area and evaluated its association with child asthma control.
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Evaluation Value of Allergy in Adenoid Hypertrophy Through Blood Inflammatory Cells and Total Immunoglobulin E Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Hailing Zhang, Yanliang Sun, Chaofan Shen, Peng Jin, Wei Yue, Qinqin Zhang, Fengjuan Zhu, Hongping Zhang
Objective: Previous reports have indicated the close association of allergy with adenoid hypertrophy (AH). The aim of this study was to evaluate whether the inflammatory cells and total immunoglobulin E (IgE) in blood could be useful in the diagnosis of allergy in AH.
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Role of Serum Endocan Levels in Children with Bacterial and Viral Pneumonia: A Prospective, Case-Control Study Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Serçin Taşar, İlknur Fidancı, İsmail Bulut, Gül Kırtıl, Rukiye Ünsal Saç, Medine Ayşin Taşar
Introduction and Objective: Endocan has been used as a biomarker in the differential diagnosis of pulmonary diseases in adults. However, there are only a limited number of studies on its use in children. In this context, the objective of this study is to evaluate the relationship between serum endocan levels in children with bacterial and viral pneumonia.
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Bridging Knowledge Gaps in Anaphylaxis Management Through a Video-Based Educational Tool Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Jumanah Karim, Sofianne Gabrielli, Bahar Torabi, Adam Byrne, Sarah De Schryver, Vanessa Gadoury-Lévesque, Reza Alizadehfar, Christine McCusker, Matthieu Vincent, Judy Morris, Jennifer Gerdts, Xun Zhang, Moshe Ben-Shoshan
Introduction: We aimed to develop and test the effectiveness of an education tool to help pediatric patients and their families better understand anaphylaxis and its management, and to improve current knowledge and treatment guidelines adherence.
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Indoor Urban Environment and Conventional Risk Factors for Pediatric Tuberculosis Among 1–12 Years Old Children in a Megacity in Pakistan: A Matched Case–Control Study Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Ambreen Sahito, Zafar Fatmi, Muhammad Masood Kadir, Fehmina Arif
Background: Estimated 1.1 million children developed tuberculosis (TB) globally in 2020. Household air pollution has been associated with increased respiratory tract infections among children. Nonetheless, there are scarce data regarding the association of indoor environment with pediatric TB.
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Food-Dependent Exercise-Induced Anaphylaxis Caused by Carrots: A Case Report Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Nami Hirai, Mika Ogata, Jun Kido, Masashi Nakamura, Nayu Sato, Nobue Takamatsu, Naoshi Shimojo, Yuji Aoki, Kayoko Matsunaga, Tomoyuki Mizukami
Background: Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare case of FDEIA caused by eating carrots.
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Children with Near-Fatal Asthma: The Use of Inhaled Volatile Anesthetics and Extracorporeal Membrane Oxygenation Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Chasity M. Custer, Erika R. O'Neil, Janaki Paskaradevan, Brian J. Rissmiller, Maria C. Gazzaneo
Background and Purpose: The use of extracorporeal membrane oxygenation (ECMO) has been described for near-fatal asthma that continues to be refractory despite maximal medical therapy.
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Comparison of Children Hospitalized for Asthma Before and During the COVID-19 Pandemic Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-12-15 Joanne Nazif, Ellen Silver, Chihiro Okada, Elissa Gross
Background: Studies suggest that children with asthma experienced improved symptom control and less frequent inpatient admission during the COVID-19 (coronavirus disease 2019) pandemic. The characteristics of hospitalized children remain less well defined.
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Comparison of Acute Phase Thymus and Activation-Regulated Chemokine (TARC) Levels in Food Protein-Induced Enterocolitis Syndrome and IgE-Dependent Food Allergy Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-09-16 Eishi Makita, Daisuke Sugawara, Sae Kuroda, Kae Itabashi, Yuka Hirakubo, Kazuhito Nonaka, Ko Ichihashi
Introduction: Patients with food protein-induced enterocolitis syndrome (FPIES) have elevated thymus and activation-regulated chemokine (TARC) levels in the acute phase. However, to the best of our knowledge, no study has evaluated TARC levels in the acute phase of immunoglobulin E-dependent food allergy (IgE-FA). If TARC elevation is a specific response to FPIES among FAs, TARC measurement may help
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Surfactant for a Patient with Refractory Pyopneumothorax and Acute Respiratory Distress Syndrome Due to Pneumococcal Necrotizing Pneumonia Complicated by a Bronchopleural Fistula Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-09-16 Zeynelabidin Ozturk, Merve Duman Küçükkuray, Suna Özdem, Hasibe Gökçe Çınar, Caner Aytekin, Özgür Çağlar
Background: Necrotizing pneumonia rarely occurs in children, but when it does it can be complicated by bronchopleural fistula, empyema, pneumothorax, sepsis, and acute respiratory distress syndrome (ARDS). Antimicrobial therapy is the cornerstone of its management; however, surgery is necessary in some cases. Ideally, surgical interventions are kept to a minimum, but this is not always possible if
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Variable Expression of Lung Disease Due to a Novel Homozygous ABCA3 Variant Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-09-16 Samia Hamouda, Alix de Becdelièvre, Salma Ben Ameur, Ines Trabelsi, Monique Fabre, Ralph Epaud, Pascale Fanen, Khadija Boussetta
Background: Mutations in the ATP-binding cassette transporter A3 (ABCA3) gene are one of the most common surfactant disorders leading to interstitial lung diseases (ILD). The clinical spectrum and severity of lung disease caused by ABCA3 deficiency due to missense variants is variable.
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A Rare Autoinflammatory Disorder in a Pediatric Patient with Favorable Response to Etanercept: Sideroblastic Anemia with B Cell Immunodeficiency, Periodic Fevers, and Developmental Delay Syndrome Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-09-16 Rabia Miray Kisla Ekinci, Aslıhan Zararsiz, Gizem Urel Demir, Ozlem Anlas
Introduction: Sideroblastic anemia with B cell immunodeficiency, periodic fevers, and developmental delay (SIFD) syndrome is caused by biallelic TRNT1 mutations. TRNT1 gene encodes a CCA-adding tRNA nucleotidyl transferase enzyme. Mutant TRNT1 results in immunodeficiency and anemia in various degrees, accompanied by several organ involvement.
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Interstitial Lung Disease in an Adolescent Girl with Lipopolysaccharide-Responsive Beige-Like Anchor Deficiency Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-09-16 Gökçen Dilşa Tuğcu, Sanem Eryılmaz Polat, Ayşe Metin, Diclehan Orhan, Güzin Cinel
Background: Previously, lipopolysaccharide-responsive beige-like anchor (LRBA) deficiency was categorized as a subtype of common variable immune deficiency. Research shows that LRBA deficiency is caused by dysregulation of T cell activation and expansion; it is placed under the category of immune dysregulation with cytotoxic T lymphocyte-associated protein 4 (CTLA-4) haploinsufficiency. Cohort studies
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Digital Inhaler Technology: Is It Ready for Prime Time? Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-09-01 Scott Bickel,Ronald Morton,Nemr Eid
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The Role of Care Coordinators for Children with Respiratory Technologies and Home Nursing Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Sarah A. Sobotka, Emma Lynch, Rishi Agrawal
Background: Children with respiratory technologies, particularly those with mechanical ventilation, represent a growing population that require complex home nursing, medical equipment, outpatient medical and habilitative supports to live and thrive in their community. Care coordination is essential to support these children and their families to navigate and integrate key community-based health and
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Psychological Distress and Drug Provocation Test-Related Anxiety Levels of Pediatric Patients and Their Parents Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Ozge Yilmaz Topal, Irem Turgay Yagmur, Ilknur Kulhas Celik, Ozden Sukran Uneri, Muge Toyran, Betul Karaatmaca, Ersoy Civelek, Emine Dibek Misirlioglu
Background: Drug provocation tests (DPTs) are the gold standard for the diagnosis of drug hypersensitivity reaction (DHR). To the best of our knowledge, there is no previous study reporting DPT-related anxiety levels in children and their parents. This study aimed to determine the difference in pre- and post-DPT anxiety levels of parents and children who were informed of the possibility of another
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School Nurse Perspectives on School-Supervised Asthma Therapy: A Qualitative Study Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Shushmita Hoque, Janki Luther, Raphael Mizrahi, Lynn B. Gerald, Wanda Phipatanakul, Stephenie C. Lemon, Milagros C. Rosal, Nancy Byatt, Lori Pbert, Michelle Trivedi
Background: School-supervised asthma therapy improves asthma outcomes for children, yet this strategy is not widely utilized. School nurses play a vital role in this intervention, yet their perspectives on school-supervised asthma therapy have not been thoroughly examined.
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Evaluation of Frequency and Characteristics of Drug Allergy in Pediatric Patients with Cystic Fibrosis Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Zeynep Şengül Emeksiz, Pınar Metbulut, Şule Selin Akyan Soydaş, Gökçen Tuğcu, Güzin Cinel, Emine Dibek Mısırlıoğlu
Background: Previous studies reported that the prevalence of drug allergy is higher in patients with cystic fibrosis (CF) than in the general population. It is important to exclude or confirm the drug allergy diagnosis with detailed allergic evaluation for preventing drug allergy overdiagnosis. Our study aims to determine the actual frequency of drug allergy proven by diagnostic tests in children with
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Comparison of Two Weaning Methods from Heated Humidified High-Flow Nasal Cannula Therapy in Pediatric Intensive Care Unit Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Muhammed Udurgucu, Hatice Albayrak, Hatice Elif Kinik Kaya, Nazik Yener
Background and Objective: Although high-flow nasal cannula (HFNC) is widely used in children, there is no consensus on the methods for starting, maintenance, and weaning. The aim of this study was to compare weaning methods in children.
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Development and Validation of a Differential Diagnosis Model for Acute Appendicitis and Henoch-Schonlein Purpura in Children Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Yishan Zhan, Min Wu, Kehao Li, Qiang Chen, Nuoya Li, Weiming Zheng, Yourong Zhu, Xiaojie Peng, Shouhua Zhang, Qiang Tao
Objective: To study and develop a predictive model for the differential diagnosis of acute appendicitis (AA) and Henoch-Schonlein purpura (HSP) in children and to validate the model internally and externally.
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Could Age and Oral Challenge Outcomes Identify High-Risk Patients During Cow's Milk Oral Immunotherapy? Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Handan Duman Senol, Ezgi Topyildiz, Ezgi Ulusoy Severcan, Sanem Eren Akercan, Nursen Cigerci Gunaydin, Figen Gulen, Esen Demir
Objective: Severe immunglobuline E (IgE)-mediated reactions during oral immunotherapy (OIT) are major obstacles to treatment. The present study aimed to evaluate and identify clinical and laboratory biomarkers of adverse events during OIT among children with cow's milk (CM) allergy.
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Racial and Ethnic Differences of Influenza-Associated Pediatric Hospitalizations and Deaths, 2008–2017 Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-06-16 Shelease C. O'Bryant, Deepa Dongarwar, Hamisu M. Salihu, Susan Gillespie
Background: Influenza is one of the most common causes of acute respiratory infections in children; its complications are a leading cause of morbidity and mortality. There is a paucity of pediatric data on influenza disparities among racial/ethnic minorities. Our study assesses if there are racial/ethnic differences in hospitalizations and mortality in children infected with influenza.
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Is Bronchodilation Testing Routinely Useful in All Asthmatic Children? Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-21 Maria Angela Tosca, Irene Schiavetti, Maria Binelli, Miraglia del iudice Michele, Giorgio Ciprandi
Background: The reversibility of bronchial obstruction is needed to diagnose asthma. Bronchodilation (BD) testing is, therefore, used in asthma work-up. This study explored the benefit of performing BD testing in asthmatic children without bronchial obstruction.
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Cost Utility of Intermittent Inhaled Corticosteroids in Preschoolers with Viral-Triggered Wheeze Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-21 Jefferson Antonio Buendía, Diana Guerrero Patiño, Juan Esteban Giraldo Ramírez
Background: Evidence has demonstrated that adding intermittent inhaled corticosteroids (ICS) to treatment with short-acting b2-agonists (SABAs) in children 5 years of age and younger who experience intermittent viral-induced wheezing (VIW) reduces the risk of severe exacerbations. However, there is concern about whether the extra benefit offered by this drug outweighs the additional cost. This study
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Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-21 Zeynep Kihtir, Kıymet Çelik, Funda Tayfun Küpesiz, Osman Alphan Küpesiz, Dilara Fatma Kocacik Uygun, Sema Arayici, Hakan Ongun, İpek Acarbulut, Celal Sağlam, Gülay Ceylaner, Ayşen Bingöl
Background: Specific granule deficiency (SGD) is a rare immunodeficiency associated with CCAT/enhancer-binding protein epsilon (CEBPE) gene variants. It can cause severe recurrent infections and is lethal without successful stem cell transplantation. Few cases with SGD of both type 1 and type 2 have been described in the literature. In this study, we present the first report of a case with a novel
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Anxiety Levels and Changes in Health and Hygiene Behaviors in Mothers of Children with Asthma in Early COVID-19 Lockdown in Turkey Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-21 Ozlem Sancakli, Tuba Tuncel, Sanem Eren Akarcan, Ali Kanık, Gonca Özyurt, Emine Ece Ozdogru
Objective: The restrictions imposed by the coronavirus disease 2019 (COVID-19) pandemic have caused significant changes in people's lives. This study aimed to investigate anxiety levels and changes in health and hygiene behaviors in mothers of children with asthma in early COVID-19 lockdown in Turkey.
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Inhaled Dry Powder Mannitol Treatment in Pediatric Patients with Cystic Fibrosis: Evaluation of Clinical Data in a Real-World Setting Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-21 Ipek Duman, Gokcen Ünal, Asli Imran Yilmaz, Ahmet Yasin Güney, Yasemin Durduran, Sevgi Pekcan
Background: Cystic fibrosis (CF) is a genetic disorder, in which defective clearance of airway secretions leads to progressive lung function loss. Inhaled mannitol is used to increase sputum and mucociliary clearance. There are little data from real-world studies on the effectiveness of mannitol in children. Our objective was to evaluate the spirometry and clinical results of mannitol in pediatric
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Psychological State of Parents of Children with Primary Immunodeficiencies During the COVID-19 Pandemic Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-21 Berhan Akdağ, Arif Önder, Özge Gizli Çoban, Dilara Fatma Kocacık Uygun, Aslı Sürer Adanır, Aybike Erdem, Enes Çelik, Zehra Ece Soğucak, Ayşen Bingöl
Background: COVID-19 has affected humanity not only physically but also mentally. It was expected to have impact on high-risk groups such as the immunocompromised patients and parents/caregivers of them. Our study was aimed to investigate the COVID-19 related anxiety, post-traumatic stress levels, and sleep-related parameters of the parents of children with primary immunodeficiency.
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Health Disparities in Communities of Color During the COVID-19 Pandemic Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2022-03-01 Mary Cataletto,LeRoy Graham,Michelle Yu,Michael Foggs
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Diurnal Variations in Skin Prick Testing Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-12-15 Elisa Ochfeld, Brian Cheng, Nina Bowsher, Anna Fishbein
Background: Prior research suggests that skin prick testing (SPT) might be larger in the afternoon, with unclear clinical significance.
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The Effect of Serum Vitamin D Level on Allergic Rhinitis Symptoms in Children Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-12-16 Zeynep Haziroglu Okmen, Mehmet Halil Celiksoy, Erdem Topal
Background: Allergic rhinitis (AR) is a chronic disease that is becoming increasingly common worldwide and has a negative impact on school performance, work performance, and quality of life. The aim of this study was to investigate the effect of vitamin D on the symptoms of AR in children.
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Salivary C-Reactive Protein and Mean Platelet Volume in the Diagnosis and Follow-Up of Community-Acquired Pneumonia in Infants Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-12-16 Ahmed Omran, Hala Abohadid, Mai H.S. Mohammad, Sherien Shalaby
Background: Community-acquired pneumonia (CAP) in infants is a major cause of morbidity and mortality, especially in developing countries. Increased salivary C-reactive protein (CRP) levels have been demonstrated in neonatal pneumonia and other diseases. We investigated the applicability of CRP and mean platelet volume (MPV) in the diagnosis and follow-up of CAP in infants.
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Th17 Lymphocytes in Children with Asthma: Do They Influence Control? Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-12-16 Verónica Moreno-Córdova, Roberto Berra-Romani, Lilian K. Flores Mendoza, Julio Reyes-Leyva
Background: Allergic asthma was considered as an inflammation mediated by specific CD4+ helper lymphocytes (Th2); however, this paradigm changed in 2005, when a third group of helper cells called Th17 cells were identified. Th17 lymphocytes are the main source of interleukin (IL)-17A–F, IL-21, and IL-22; however, their physiological role in children is unclear. This study aimed to determine the percentage
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Telehealth and Remote Patient Monitoring After the COVID Pandemic. Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-11-01 Satyanarayan Hegde,Nemr S Eid
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Determining the Best Tool Comparable with Global Initiative for Asthma Criteria for Assessing Pediatric Asthma Control Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-09-08 Ayşegül Akan, Emine Dibek Mısırlıoğlu, Ersoy Civelek, Can Naci Kocabaş
Background: Guidelines such as Global Initiative for Asthma (GINA) recommend disease control as the mainstay of asthma management.
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Annual Respiratory Evaluations in Congenital Central Hypoventilation Syndrome and Changes in Ventilatory Management Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-09-08 Amit S. Shah, Roberta M. Leu, Thomas G. Keens, Ajay S. Kasi
Background: Annual in-hospital respiratory evaluations (AREs) during wakefulness and sleep are recommended to assess ventilatory requirements in patients with congenital central hypoventilation syndrome (CCHS) aged ≥2–3 years based on expert consensus. This study aimed to determine if AREs in patients with CCHS led to changes in ventilatory management.
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A Serum Level of Squamous Cell Carcinoma Antigen as a Real-Time Biomarker of Atopic Dermatitis Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-09-08 Masaki Shimomura, Yuka Okura, Yutaka Takahashi, Ichiro Kobayashi
Background: Although serum levels of squamous cell carcinoma antigen (SCCA) are elevated in atopic dermatitis (AD), their clinical utility has not been fully elucidated.
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Successful Rapid Desensitization to Micafungin in a Pediatric Patient Pediatr. Allergy Immunol. Pulmonol. (IF 0.9) Pub Date : 2021-09-08 Stephanie L. Ward, Michelle C. Maciag, Sarah Jones, Joyce Lee, John Lee, Ana Dioun Broyles
Introduction: Echinocandin antifungal medications including micafungin are being used more commonly in the treatment of invasive fungal infections in both pediatric and adult patients. Micafungin is also a first-line therapeutic option for candidemia and antifungal prophylaxis in a variety of clinical settings. Hypersensitivity reactions have not been well described; however, isolated cases have been