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Insights into the role of complement system in the pathophysiology of endometriosis Immunol. Lett. (IF 3.276) Pub Date : 2021-01-15 Danilo Rahal; Fabiana Andrade; Renato Nisihara
Endometriosis (EM) is a gynecologic disorder characterized by the presence of endometrium-like tissue outside of normal location that affects up to 10 % of all women in reproductive age. The pathogenesis of endometriosis is not completely known. The relationship between complement and EM has already been demonstrated in some studies, indicating an important role in the pathophysiology of the disease
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Hispolon inhibits RANKL induced osteoclast differentiation in vitro Immunol. Lett. (IF 3.276) Pub Date : 2021-01-08 Dinesh Thimmuri; Shantanu P.A.; Syamprasad N.P.; Aasiya Khan; Basveshwar Gawali; Bishal Rajdev; Chanakya Adhikari; Ravichandiran V.; Pawan Sharma; VGM Naidu
Hispolon (HISP) is a bioactive compound isolated from Phellinu linteus. It has various pharmacological activities, including antioxidant, anti-inflammatory, and anti-cancer. However, its anti-osteoclastogenic activity has not yet been reported. Hence, in the current study, we have explored the anti-osteoclastogenic activity of HISP and elucidated the molecular mechanisms. HISP inhibited the RANKL induced
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“Oral Co-Administration of Bivalent Protein r-BL with U-Omp19 Elicits Mucosal Immune Responses and reduces S. Typhimurium shedding in BALB/c Mice.” Immunol. Lett. (IF 3.276) Pub Date : 2021-01-15 Pradnya Sukhadev Nikam; Joseph J. Kingston; Anil Kumar Belagal Motatis
The increase in international food trade and travel has dramatically increased the global incidences of Salmonellosis. In the light of widespread resistance to frontline antibiotics, oral vaccines remain the most reliable alternative. In this study, the fusion protein, r-BL was rationally constructed by splicing the Salmonella Typhimurium sseB and ompL genes through G4S linker by over-lap extension
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Immune reactivity during COVID-19: Implications for treatment Immunol. Lett. (IF 3.276) Pub Date : 2021-01-06 Claudio Napoli; Giuditta Benincasa; Clelia Criscuolo; Mario Faenza; Cinzia Liberato; Mariangela Rusciano
Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characterized by cardiovascular comorbidities and immunosenescence. Besides, increased levels
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MicroRNA-144-3p enhances LPS induced septic acute lung injury in mice through downregulating Caveolin-2 Immunol. Lett. (IF 3.276) Pub Date : 2021-01-05 Ruiming Xu; Zhengyi Shao; Qiumei Cao
Objective The emphasis of this study focused on the possible implication and the mechanism of miR-144−3p in septic acute lung injury (ALI) condition. Methods Mice were pre-injected with miR-144−3p agomir, miR-144−3p antagomir, sh-Caveolin-2 or PBS before 10 mg/kg LPS induced sepsis model establishment. The ratio of wet weight of lung tissues and body weight (W/W) was calculated. The pathological changes
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MiR-30a-3p ameliorates oxidative stress in rheumatoid arthritis synovial fibroblasts via activation of Nrf2-ARE signaling pathway Immunol. Lett. (IF 3.276) Pub Date : 2021-01-12 Xiaolong Lv; Jiuqin Huang; Hongqi Wang
The downregulation of miR-30a-3p has been reported in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS); however, it is poorly understood its possible involvement and the underlying mechanism. The effects of miR-30a-3p overexpression on the proliferation and apoptosis as well as oxidative stress injury were evaluated in rats RA-FLS. The targeting relationship between miR-30a-3p and Kelch-like
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Distinct cell death markers identified in critical care patient survivors diagnosed with sepsis Immunol. Lett. (IF 3.276) Pub Date : 2021-01-03 Chandra Shekar Mallarpu; Meenakshi Ponnana; Sudhir Prasad; Maneendra Singarapu; Jean Kim; Neda Haririparsa; Nemanja Bratic; Harvinder Brar; Lakshmi Kiran Chelluri; Charitha Madiraju
Sepsis is an abnormal immune response to infection characterized by an overwhelming systemic inflammation and cell death. Non-apoptotic cell death pertaining to pyroptosis, necroptosis and autophagy contribute to sepsis pathogenesis apart from classical apoptotic cell death. The objective of the current study is to investigate the presence of molecular markers of relevance to apoptotic and non-apoptotic
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Immunodeficiency and thymoma in Good syndrome: Two sides of the same coin Immunol. Lett. (IF 3.276) Pub Date : 2021-01-05 Kissy Guevara-Hoyer; Jesús Fuentes-Antrás; Joaquín Calatayud Gastardi; Silvia Sánchez-Ramón
Good Syndrome is a rare clinical entity first described as the conjunction of thymoma and hypogammaglobulinemia, and more recently depicted as a complex disease integrating a medical history of thymoma with humoral immunodeficiency (more accurately stated: hypogammaglobulinemia) with or without cellular immunodeficiency, recurrent infections, autoimmunity, paraneoplastic syndromes and diverse aberrations
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Abnormal Thymic B Cell Activation and Impaired T Cell Differentiation in Pristane-Induced Lupus Mice Immunol. Lett. (IF 3.276) Pub Date : 2021-01-08 Wen-Yan Tang; Yan-Hua Zhang; Yi-Shu Zhang; Yao Liao; Jie-Si Luo; Jia-Hua Liu; Chun-Jin Peng; Yan-Lai Tang; Dan-Ping Huang; Xi Sun; Xue-Qun Luo
Changes in the thymus and potential mechanisms underlying the pathogenesis in pristane-induced lupus (PIL) mice are poorly understood. This study aimed to systematically and specifically examine changes in the thymus and the potential mechanisms responsible for immunological abnormalities in PIL mice. The results showed that PIL mice exhibit serious thymic hyperplasia, an elevated thymus index, a damaged
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Integrin αvβ6 cooperates with resiquimod to restore antigen-specific immune tolerance in airway allergy Immunol. Lett. (IF 3.276) Pub Date : 2020-12-29 Fei Ma; Yuan-Yi Zhang; Gui Yang; Li-Hua Mo; Da-Bo Liu; Li-Teng Yang; Zhi-Gang Liu; Yan Ning; Ping-Chang Yang
Background Integrin αvβ6 can convert the transforming growth factor (TGF)-β precursor to the mature form. Resiquimod (R848) can generate TGF-β-producing regulatory T cells (Treg). Thus, to concurrent administration of specific antigen and R848 may generate antigen-specific Tregs, that is expected to restore immune tolerance in subjects with airway allergic diseases (AAD). Methods A bio-nanoparticle
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Establishment of universal human embryonic stem cell lines Immunol. Lett. (IF 3.276) Pub Date : 2020-12-09 MingYue Kong; Di Zhou
The potential application of human embryonic stem cells in regenerative medicine using cell, tissue or organ transplantation has aroused great interest. However, HLA incompatibility between donor cells or tissues and the recipient is a primary obstacle to the use of unmatched human embryonic stem cells and their derivatives as donor ‘grafts’ for patient treatment without some form of immunosuppressive
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Dynamics of TIGIT and PD-1 expression on NK cells during the course of normal pregnancy Immunol. Lett. (IF 3.276) Pub Date : 2020-12-29 Yanshi Wang; Daojing Li; Ting Yu; Meihong Hu; Juan Xing; Shun Bai; Wanjun Qu; Xianhong Tong
Problem Immune checkpoint molecules are receptors that can transmit inhibitory signals into cells to negatively modulate the immune response. However, their roles in NK cells during normal pregnancy remain poorly understood. Method of Study Peripheral blood samples were collected from women during the first, second and third trimesters of pregnancy. Peripheral blood NK (pNK) cells and T cells were
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Improved pulmonary function test (PFT) after 1 one year of Sublingual Immunotherapy (SLIT) as adjunct to pharmacotherapy in mild allergic asthmatics Immunol. Lett. (IF 3.276) Pub Date : 2020-12-16 Afaq H. Beigh; Roohi Rasool; Fizalah Kawoosa; Sharika manzoor; Rabiya Rashid; Khurshid Iqbal Andrabi; Zafar A. shah; Taha Qureshi
Background Allergen immunotherapy (AIT) is a promising treatment for allergic disease that induces immunological tolerance through the administration of specific allergens. The study of AIT is in its early stage and its clinical effects are not well elucidated. The present study was aimed at determining the effect of AIT on pulmonary function and serum variables of mild allergic asthma patients. Methods
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BML-111, the lipoxin A4 agonist, modulates VEGF or CoCl2-induced migration, angiogenesis and permeability in tumor-derived endothelial cells Immunol. Lett. (IF 3.276) Pub Date : 2020-12-26 Lan Lin; Qingyu Wang; Fen Xu; Xuliang Luo; Jing Xu; Liping Yan; Qing Li; Hua Hao
Tumor angiogenesis plays a vital role in carcinogenesis, cancer progression, and metastasis. Lipoxin A4 (LXA4) is an endogenously-produced family of effective anti-inflammatory with a potent inhibitory effect on angiogenesis. However, BML-111, a LXA4 agonist, its governing tumor-derived endothelial cells (Td-EC) mechanisms remain unknown. In the present study, we utilized VEGF or CoCl2 to mimic tumor
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The Immune Dysregulation of Common Variable Immunodeficiency Disorders Immunol. Lett. (IF 3.276) Pub Date : 2020-12-14 Suran L. Fernando; Helena S-I. Jang; Jamma Li
Common variable immunodeficiency (CVID) is established as a heterogeneous collection of disorders of immune dysregulation rather than an infectious complication of antibody deficiency. Approximately 70% of patients have one or more of the non-infectious complications of autoimmunity, enteropathy, polyclonal lymphocytic and malignancy. The CVID-disorders represent a particular challenge as they fall
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Immuno-hippo: Research progress of the hippo pathway in autoimmune disease Immunol. Lett. (IF 3.276) Pub Date : 2020-12-18 Paipai Guo; Zhen Wang; Zhengwei Zhou; Yu Tai; Aijun Zhang; Wei Wei; Qingtong Wang
Extensive research in Drosophila and mammals has identified the core components of Hippo signaling, which controls gene expression. Studies of Drosophila have demonstrated the highly conserved Hippo pathway controls tissue homeostasis and organ size by regulating the balance between cell proliferation and apoptosis. Recent work has indicated a potential role of the Hippo pathway in regulating the immune
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The impact of ageing on monocytes and macrophages Immunol. Lett. (IF 3.276) Pub Date : 2020-12-10 Roel P.H. De Maeyer; Emma S. Chambers
Ageing is a global burden. Increasing age is associated with increased incidence of infections and cancer and decreased vaccine efficacy. This increased morbidity observed with age, is believed to be due in part to a decline in adaptive immunity, termed immunosenescence. However not all aspects of immunity decrease with age as ageing presents with systemic low grade chronic inflammation, characterised
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Improved engraftment of human peripheral blood mononuclear cells in NOG MHC double knockout mice generated using CRISPR/Cas9 Immunol. Lett. (IF 3.276) Pub Date : 2020-11-27 Yuyo Ka; Ikumi Katano; Eiko Nishinaka; Jochen Welcker; Misa Mochizuki; Kenji Kawai; Motohito Goto; Kayo Tomiyama; Tomoyuki Ogura; Taichi Yamamoto; Mamoru Ito; Ryoji Ito; Riichi Takahashi
Humanized mice are widely used to study the human immune system in vivo and develop therapies for various human diseases. Human peripheral blood mononuclear cells (PBMC)-engrafted NOD/Shi-scid IL2rγnull (NOG) mice are useful models for characterization of human T cells. However, the development of graft-versus-host disease (GVHD) limits the use of NOG PBMC models. We previously established a NOG-major
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Increased peripheral helper T cells type 17 subset correlates with the severity of psoriasis vulgaris Immunol. Lett. (IF 3.276) Pub Date : 2020-11-21 Wenjing Liu; Xuefeng Zhou; Ao Wang; Jie Ma; Yanping Bai
Recently, a new subgroup of T cells, named peripheral helper T (Tph) cells, has been implicated in autoimmune pathogenesis. An imbalance of Tph cell subsets influences the severity of immune-related diseases. However, the characteristics and roles of Tph cell subsets in psoriasis remain unknown. Programmed cell death 1-positive, chemokine C-X-C receptor (CXCR) 5-negative Tph cells can be divided into
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Neuroimmune communication in infection and pain: Friends or foes? Immunol. Lett. (IF 3.276) Pub Date : 2020-11-25 Victor Fattori; Camila R. Ferraz; Fernanda S. Rasquel-Oliveira; Waldiceu A. Verri
Clinically, a variety of micro-organisms cause painful infections. Before seen as bystanders in the context of infections, recent studies have demonstrated that, as immune cells, nociceptors can sense pathogen-derived products. Nociceptors and immune cells, therefore, have evolved to communicate with each other to control inflammatory and host responses against pathogens in a complementary way. This
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Gut microbiota, immunity and pain Immunol. Lett. (IF 3.276) Pub Date : 2020-11-25 Matteo Santoni; Francesca Miccini; Nicola Battelli
The interplay between microbiota and nervous system has been associated with a variety of diseases, including stress, anxiety, depression and cognition. The growing body of evidences on the essential role of gut microbiota in modulating acute and chronic pain has opened a new frontier for pain management. Gut microbiota is involved in the development of visceral, inflammatory and neuropathic pain.
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Combining miR-23b exposure with mesenchymal stem cell transplantation enhances therapeutic effects on EAE Immunol. Lett. (IF 3.276) Pub Date : 2020-11-22 Ruixue Hu; Weiqi Lv; Sifan Zhang; Yumei Liu; Bo Sun; Yanting Meng; Qingfei Kong; Lili Mu; Guangyou Wang; Yao Zhang; Hulun Li; Xijun Liu
Bone marrow mesenchymal stem cells (BMSCs) have the immuno-modulatory capacity to ameliorate autoimmune diseases, such as multiple schlerosis (MS), systemic lupus erythematosus and rheumatoid arthritis. However, BMSC-mediated immunosuppression can be challenging to achieve. The efficacy of BMSC transplantation may be augmented by an adjuvant therapy. Here, we demonstrated that treatment of mice with
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Ficolin-3 in rheumatic fever and rheumatic heart disease Immunol. Lett. (IF 3.276) Pub Date : 2020-11-21 Sandra Jeremias Catarino; Fabiana Antunes Andrade; Lorena Bavia; Luiza Guilherme; Iara Jose Messias-Reason
Rheumatic fever (RF) and chronic rheumatic heart disease (RHD) are complications of oropharyngeal infection caused by Streptococcus pyogenes. Despite the importance of the complement system against infections and autoimmunity diseases, studies on the role of the lectin pathway in RF and RHD are scarce. Thus, our aim was to evaluate the association of ficolin-3 serum levels, FCN3 polymorphisms and haplotypes
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Progress in research into the role of abnormal glycosylation modification in tumor immunity Immunol. Lett. (IF 3.276) Pub Date : 2020-11-10 Hui-min Liu; Le-le Ma; Bo Cao; Jun-zhi Lin; Li Han; Chun-yu Li; Run-chun Xu; Ding-kun Zhang
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Role, function and regulation of the thymocyte selection-associated high mobility group box protein in CD8+ T cell exhaustion Immunol. Lett. (IF 3.276) Pub Date : 2020-11-11 Yanmin Cheng; Zhaozhao Shao; Li Chen; Qiaoyu Zheng; Qiqi Zhang; Wenjie Ding; Meng Zhang; Qiongfang Yu; Dian Gao
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STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation Immunol. Lett. (IF 3.276) Pub Date : 2020-10-21 Périne Millot; Carine San; Evangeline Bennana; Baptiste Porte; Nicolas Vignal; Jacques Hugon; Claire Paquet; Benoit Hosten; François Mouton-Liger
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Role of adipose-associated lymphoid tissues in the immunological homeostasis of the serosal surface Immunol. Lett. (IF 3.276) Pub Date : 2020-11-06 Xinkai Jia; Gergely Berta; Fanni Gábris; Zoltán Kellermayer; Péter Balogh
Although not typical lymphoid organs, analysis of the visceral adipose-associated lymphoid tissues has recently substantially expanded our knowledge about the immunological features of these elusive compartments. Recent data have highlighted their considerable complexity in cellular organization and interactions in several biological processes, including adaptive immune responses, tissue plasticity
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Pulmonary vascular improvement in severe COVID-19 patients treated with tocilizumab Immunol. Lett. (IF 3.276) Pub Date : 2020-11-05 Lorenzo Salvati; Mariaelena Occhipinti; Leonardo Gori; Luca Ciani; Alessio Mazzoni; Laura Maggi; Manuela Capone; Paola Parronchi; Francesco Liotta; Vittorio Miele; Francesco Annunziato; Federico Lavorini; Lorenzo Cosmi
As of October 2020 management of Coronavirus disease 2019 (COVID-19) is based on supportive care and off-label or compassionate-use therapies. On March 2020 tocilizumab - an anti-IL-6 receptor monoclonal antibody - was suggested as immunomodulatory treatment in severe COVID-19 because hyperinflammatory syndrome occurs in many patients similarly to the cytokine release syndrome that develops after CAR-T
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Combinatmarion treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators Immunol. Lett. (IF 3.276) Pub Date : 2020-11-01 Jooyeon Jhun; Hong-Ki Min; Hyun Sik Na; Ji ye Kwon; Jaeyoon Ryu; Keun-Hyung Cho; JeongWon Choi; KyoungAh Jung; Seon-Yeong Lee; Seok Jung Kim; Chul Woo Yang; Sung-Hwan Park; Mi-La Cho
Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in the treatment of OA. Monosodium iodoacetate (MIA)-induced arthritis of the knee joint
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Determination of in vitro and in vivo immune response to recombinant cholesterol oxidase from Mycobacterium tuberculosis Immunol. Lett. (IF 3.276) Pub Date : 2020-11-07 Izabela Szulc-Kielbik; Anna Brzostek; Justyna Gatkowska; Michal Kielbik; Magdalena Klink
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PD-1 Expression on CD8+CD28- T cells within inflammatory synovium is associated with Relapse: A cohort of Rheumatoid Arthritis Immunol. Lett. (IF 3.276) Pub Date : 2020-10-15 Faezeh Ajam; Mehrdad Aghaei; Saeed Mohammadi; Hadiseh Samiei; Nasser Behnampour; Ali Memarian
Defect in T lymphocyte homeostasis could implicate initiation and development of rheumatoid arthritis (RA). Since PD-1 plays a key role in the regulation of T lymphocytes, its expression pattern in various CD8+ T cell subsets could be so effective in RA pathogenesis. Here, we investigated the expression of PD-1 and CXCR3 on CD8+CD28- T cells in association with the IFN-γ levels in patients with RA
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Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion Immunol. Lett. (IF 3.276) Pub Date : 2020-09-28 James J. DiNicolantonio; Jorge Barroso-Aranda; Mark F. McCarty
Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation
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Two genetic variants in the promoter region of the CCL5 gene are associated with the risk of acute coronary syndrome and with a lower plasma CCL5 concentration Immunol. Lett. (IF 3.276) Pub Date : 2020-10-18 Gabriel Herrera-Maya; Gilberto Vargas-Alarcon; Julian Ramirez-Bello; Oscar Perez-Mendez; Rosalinda Posadas-Sanchez; Rebeca Lopez-Marure; Julio Granados; Betzabe Nieto-Lima; Jose Manuel Fragoso
Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three polymorphisms located in the promoter region of the CCL5 gene [CCL5 -28 G/C (rs2280788)
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Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils Immunol. Lett. (IF 3.276) Pub Date : 2020-10-24 Gui Yang; Jiang-Qi Liu; Li-Hua Mo; Xiang-Qian Luo; Jianxiang Li; Zhi-Qiang Liu; Da-Bo Liu; Zhi-Gang Liu; Ping-Chang Yang; Jian-Bo Shi
Background The pathogenesis of airway allergic disorders (AAD) needs to be further investigated. Eosinophils (Eos) are the canonical effector cells in AAD attacks. Bcl2 like protein-12 (Bcl2L12) is an apoptosis inhibitor and an immune regulator. Eos have the defects of apoptosis. This study aims to investigate the role of Bcl2L12 in the AAD pathogenesis by regulating Eo activities. Methods Human nasal
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Aryl hydrocarbon receptor connects dysregulated immune cells to atherosclerosis Immunol. Lett. (IF 3.276) Pub Date : 2020-10-11 Fengge Wang; Shuangchao Liang; Jiqiong Hu; Yuekang Xu
As a chronic inflammatory disease with autoimmune components, atherosclerosis is the major cause of cardiovascular morbidity and mortality. Recent studies have revealed that the development of atherosclerosis is strongly linked to the functional activities of aryl hydrocarbon receptor (AHR), a chemical sensor that is also important for the development, maintenance, and function of a variety of immune
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Antigenic competition in the generation of multi-virus-specific cell lines for immunotherapy of human cytomegalovirus, polyomavirus BK, Epstein-Barr virus and adenovirus infection in haematopoietic stem cell transplant recipients Immunol. Lett. (IF 3.276) Pub Date : 2020-10-05 Kateřina Roubalová; Šárka Němečková; Jitka Kryštofová; Petr Hainz; Markéta Pumannová; Eva Hamšíková
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IL-18 variant increases risk of enhanced HBV DNA replication in chronic hepatitis Immunol. Lett. (IF 3.276) Pub Date : 2020-10-07 Walid Ben Selma; Sana Alibi; Mohamed Ali Smach; Afef Saad; Jalel Boukadida
Background The outcome ofhepatitis B (HBV) infection is influenced by immune responses and host genetics. Interleukin-18 (IL-18) is a determinant factor in controlling the balance of Th1/Th2 during antiviral response.Weexamine therole of two functional polymorphisms -607A/C and-137A/C inIL-18 gene with risk of chronic HBV infection. Methods and Results Genomic DNA isolates were obtained from 200 seropositive
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Psychedelics as a novel approach to treating autoimmune conditions Immunol. Lett. (IF 3.276) Pub Date : 2020-10-07 Caitlin Thompson; Attila Szabo
With a rise in the incidence of autoimmune diseases (AiD), health care providers continue to seek out more efficacious treatment approaches for the AiD patient population. Classic serotonergic psychedelics have recently been gaining public and professional interest as novel interventions to a number of mental health afflictions. Psychedelics have also been shown to be able to modulate immune functions
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“Cytokine storm”, not only in COVID-19 patients. Mini-review Immunol. Lett. (IF 3.276) Pub Date : 2020-09-29 Norbert Lukan
Cytokine storm is a form of uncontrolled systemic inflammatory reaction activated by a variety of factors and leading to a harmful homeostatic process, even to patient’s death. Triggers that start the reaction are infection, systemic diseases and rarely anaphylaxis. Cytokine storm is frequently mentioned in connection to medical interventions such as transplantation or administration of drugs. Presented
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Regulation of cellular immunity by activating transcription factor 4 Immunol. Lett. (IF 3.276) Pub Date : 2020-09-28 Debasmita Mukherjee; Lena S. Bercz; Molly A. Torok; Thomas A. Mace
Activating transcription factor 4 (ATF4) is a DNA binding transcription factor belonging to the family of basic Leucine zipper proteins. ATF4 can be activated in response to multiple cellular stress signals including endoplasmic reticulum stress in the event of improper protein folding or oxidative stress because of mitochondrial dysfunction as well as hypoxia. There are multiple downstream targets
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Successful DAA therapy for chronic hepatitis C reduces HLA-DR on monocytes and circulating immune mediators: a long-term follow-up study. Immunol. Lett. (IF 3.276) Pub Date : 2020-09-15 Natalia Fonseca Rosário,Geórgia do Nascimento Saraiva,Thalia Medeiros,Mariana Gandini,Gilmar de Souza Lacerda,Paulo Emílio Corrêa Leite,Thaís Guaraná de Andrade,Elzinandes Leal de Azeredo,Analúcia Rampazzo Xavier,Andrea Alice Silva
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Interplays between inflammasomes and viruses, bacteria (pathogenic and probiotic), yeasts and parasites Immunol. Lett. (IF 3.276) Pub Date : 2020-09-22 Hanna Antushevich
In recent years, scientists studying the molecular mechanisms of inflammation have discovered an amazing phenomenon – the inflammasome – a component of the innate immune system that can regulate the functional activity of effector cells during inflammation. At present, it is known that inflammasomes are multimolecular complexes (cytosolic multiprotein oligomers of the innate immune system) that contain
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Plasticity and regulatory mechanisms of human ILC2 functions. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-18 Laura Maggi,Capone Manuela,Alessio Mazzoni,Francesco Liotta,Lorenzo Cosmi,Francesco Annunziato
Human group 2 innate lymphoid cells (ILC2) represent the innate counterpart of Th2 cells and cooperate with them in helminths protection and in the pathogenesis of allergic diseases. Some reports described ILC2 plasticity and few studies investigated the cellular and molecular mechanisms regulating human ILC2 functions. The aim of this study is to define how immune deviation and immune regulation control
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The effect of anti IL-2/IL-2 complex versus stand-alone low dose of IL-2 on Imiquimod induced psoriasis like skin inflammation model. Immunol. Lett. (IF 3.276) Pub Date : 2020-09-16 Samar Salman,Yasmina Ahmed El Attar,Mohamed Labib Salem,Shaimaa Mostafa Kashef,Abdel-Aziz A Zidan,Amany Mohammad Abdel-Latif
Background Psoriasis is a chronic inflammatory skin condition. Low dose Il-2 and anti IL2/IL-2 complex were recently thought to induce T regulatory cells inhibiting the autoinflammatory reaction. Aim of the work The aim of the work is to assess the effect of anti IL2/IL-2 complex versus low dose of IL2 on psoriasis like skin inflammation induced by imiquimod in mouse model and its effect on Treg cells
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Macrophage-derived exosomes in cancers: Biogenesis, functions and therapeutic applications. Immunol. Lett. (IF 3.276) Pub Date : 2020-09-02 Junjiang Liu,Fanglong Wu,Hongmei Zhou
Macrophages are fundamental to promote tumorigenesis, tumor development and metastasis, and chemotherapy resistance through modulating tumor microenvironment and cancer cells. Recently, increasing studies have shown that exosomes could play a crucial role in orchestrating the crosstalk between macrophages and cancer cells. Exosomes, as one of the extracellular vehicles, deliver a diverse cast of molecules
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Abnormal membrane-bound and soluble programmed death ligand 2 (PD-L2) expression in systemic lupus erythematosus is associated with disease activity. Immunol. Lett. (IF 3.276) Pub Date : 2020-09-03 Min Tong,Xiaohui Fang,Jie Yang,Pingping Wu,Yundi Guo,Jing Sun
Programmed death ligand (PD-L) 2 and PD-L1 are the second and first ligands, respectively, for programmed cell death-1 protein (PD-1), which is one of the key factors responsible for inhibitory T cell signaling, mediating mechanisms of tolerance and providing immune homeostasis. Studies have shown that PD-1 and its ligand PD-L1 are abnormally expressed in autoimmune diseases, such as rheumatoid arthritis
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An assessment of toll-like receptor 7 and 8 gene polymorphisms with susceptibility to HIV-1 infection, AIDS development and response to antiretroviral therapy. Immunol. Lett. (IF 3.276) Pub Date : 2020-09-01 Imane Zaidane,Ahd Ouladlahsen,Rajaa Bensghir,Hajar Chihab,Fatima Zahra Jadid,Raouia El Fɩhry,Hanâ Baba,Kamal Marhoum El Filali,Mounia Oudghiri,Lahcen Wakrim,Soumaya Benjelloun,Sayeh Ezzikouri
Toll-like receptors (TLRs) play an important role in activating the innate immune response, inducing inflammation and initiating the adaptive immune response. In this study, we assess the influence of TLR7 and TLR8 gene polymorphisms on HIV-1 susceptibility, AIDS development, and treatment outcomes. The TLR7 and TLR8 single nucleotide polymorphisms (SNPs) were genotyped through real-time PCR in 222
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Long-term omalizumab efficacy in allergic rhinitis. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-13 Carlo Cavaliere,Elona Begvarfaj,Cristoforo Incorvaia,Bruno Sposato,Marco Brunori,Andrea Ciofalo,Antonio Greco,Marco de Vincentiis,Simonetta Masieri
Background Omalizumab therapy was found to be safe and effective as an add-on therapy for patients with poorly controlled severe asthma. Although several studies over the last decade have demonstrated its efficacy in other Immunoglobulin E related diseases, its use in such conditions is off-label. Objective This study aimed to assess the effectiveness of long-term therapy with Omalizumab in patients
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Immunoglobulin deficiency associated with a MAP2K1-related mutation causing cardio-facio-cutaneous syndrome. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-28 Chiara Leoni,Marta Tedesco,Roberta Onesimo,Valentina Giorgio,Donato Rigante,Giuseppe Zampino
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The neuro-immune axis in cancer: Relevance of the peripheral nervous system to the disease. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-19 Nina Cortese,Alessandra Rigamonti,Alberto Mantovani,Federica Marchesi
The peripheral nervous system and the immune system are critically involved in the surveillance of our body, having the ability to sense the environment, recognize danger signals and orchestrate an appropriate response. Despite the fact that these two systems have been historically considered autonomous entities, a large body of evidence has shown how they interact in many homeostatic responses and
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Plasticity of monocyte development and monocyte fates. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-16 Sébastien Trzebanski,Steffen Jung
Monocytes are circulating myeloid immune precursor cells that are generated in the bone marrow. Mature monocytes are released into the circulation and, in case of need, recruited to peripheral sites of inflammation to differentiate into monocyte-derived effector cells. In absence of overt inflammation, monocytes also extravasate into selected tissues, where they complement tissue-resident macrophage
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Immune cell-mediated opioid analgesia. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-16 Halina Machelska,Melih Ö Celik
Pathological pain is regulated by a balance between pro-algesic and analgesic mechanisms. Interactions between opioid peptide-producing immune cells and peripheral sensory neurons expressing opioid receptors represent a powerful intrinsic pain control in animal models and in humans. Therefore, treatments based on general suppression of immune responses have been mostly unsuccessful. It is highly desirable
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Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-19 Tobias Esch,Richard M Kream,George B Stefano
Integrated behavioral paradigms such as nociceptive processing coupled to anti-nociceptive responsiveness include systemically-mediated states of alertness, vigilance, motivation, and avoidance. Within a historical and cultural context, opium and its biologically active compounds, codeine and morphine, have been widely used as frontline anti-nociceptive agents. In eukaryotic cells, opiate alkaloids
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Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-17 Rabia Bilge Özgül Özdemir,Özgül Soysal Gündüz,Alper Tunga Özdemir,Özgür Akgül
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LncRNA GAS5 suppresses CD4+ T cell activation by upregulating E4BP4 via inhibiting miR-92a-3p in systemic lupus erythematosus. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-08 Qian Liu,Ya Deng,Congying Li,Huixia Xie,Qinsi Liu,Song Ming,Dengyan Wu,Fuqin Luo
Increasing evidence reveals that long noncoding RNAs (lncRNAs) are associated with autoimmune and inflammatory diseases, such as systemic lupus erythematosus (SLE). In this study, we aimed to explore the role of lncRNA growth arrest specific 5 (GAS5) in the pathogenesis of SLE. We found that lncRNA GAS5 was decreased in CD4+ T cells and plasma from SLE patients. Overepression of GAS5 inhibited activation
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A comprehensive review on miR-146a molecular mechanisms in a wide spectrum of immune and non-immune inflammatory diseases. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-15 Seyed Shahabeddin Mortazavi-Jahromi,Mona Aslani,Abbas Mirshafiey
MicroRNAs (miRNAs) are single-strand endogenous and non-coding RNA molecules with a length of about 22 nucleotides, which regulate genes expression, through modulating the translation and stability of their target mRNAs. miR-146a is one of the most studied miRNAs, due to its central role in immune system homeostasis and control of the innate and acquired immune responses. Accordingly, abnormal expression
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Preparation and in vitro activity of single chain antibodies against Alzheimer's disease. Immunol. Lett. (IF 3.276) Pub Date : 2020-08-08 Lu Fu,Yu Zhang,Xu Zhang,Wenhan Tian,Wenhui Zhang,Yu Jia,Linbo Zhang
Disease-modifying passive immunotherapies focused on reducing amyloid-beta (Aβ) deposition are a potential therapeutic strategy for Alzheimer's disease (AD). However, the results of Aβ passive immunotherapy clinical trials were unsatisfactory, largely due to the low efficacy of whole antibodies due to their relatively large molecular weight and low blood-brain barrier transmittance. Furthermore, the
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Utilization of CRISPR/Cas9 gene editing in cellular therapies for lymphoid malignancies. Immunol. Lett. (IF 3.276) Pub Date : 2020-07-17 Maryam Mehravar,Elham Roshandel,Maryam Salimi,Rouzbeh Chegeni,Majid Gholizadeh,Mohammad Hossein Mohammadi,Abbas Hajifathali
The ability to change the genetic information of immune cells is a powerful tool for basic and clinical settings. CRISPR/Cas9 gene editing technology by providing an efficient approach has accelerated immune cell therapy of cancers. Lymphoid cancers comprise a wide array of disease including lymphoma, multiple myeloma and lymphocytic leukemia. Here, we review therapeutic applications of the CRISPR/Cas9
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Homeostasis and the functional roles of CD4+ Treg cells in aging. Immunol. Lett. (IF 3.276) Pub Date : 2020-07-24 Alexey V Churov,Kylymbek Y Mamashov,Anastasiia V Novitskaia
Objective An upward trend in life expectancy has been observed in a majority of developed countries and leading to increasing in aging-related diseases. Aging is a risk factor for the development of widespread clinical conditions such as cardiovascular and autoimmune diseases, cancer, infections. Although studies have been very active, the problem of aging still remains one of the most obscure aspects
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Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of non-obese diabetic mice with Sjögren's syndrome. Immunol. Lett. (IF 3.276) Pub Date : 2020-07-21 Ying-Bo Zhou,Xiang Yuan,Qi-Kai Wang,Hong Zhang,Guo-Sheng Wang,Xiang-Pei Li,Yiping Wang,David Harris,Xiao-Mei Li
Background Overexpression of CD40 has been reported in patients with primary Sjögren’s syndrome (pSS). The increased CD40 expression promote autoimmune response and enhance inflammation in pSS. The aim of this study is to block CD40-CD154 interaction with CD40 DNA vaccine to slow the disease progression of SS in non-obese diabetic (NOD) mice. Methods Female NOD mice were treated with CD40 DNA vaccine
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