-
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination Immunol. Lett. (IF 4.4) Pub Date : 2024-03-11 Ozlem Bulut, Gizem Kilic, Priya A. Debisarun, Rutger Jan Röring, Sarah Sun, Manon Kolkman, Esther van Rijssen, Jaap ten Oever, Hans Koenen, Luis Barreiro, Jorge Domínguez-Andrés, Mihai G. Netea
Bacillus Calmette–Guérin (BCG) vaccination induces memory characteristics in innate immune cells and their progenitors, a process called mediated by epigenetic and metabolic reprogramming. Cholesterol synthesis plays an amplifying role in trained immunity through mevalonate release. Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, can inhibit cholesterol synthesis. We explored their
-
Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113–122 /IMLET_6819] Immunol. Lett. (IF 4.4) Pub Date : 2024-02-23 H, o, n, g, , L, i, u
-
Aged AβPPswe/PS1ΔE9 mice as a useful animal model for studying the link between immunological senescence and diseases Immunol. Lett. (IF 4.4) Pub Date : 2024-02-12 Jing Luan, Na Guo, Fengrui Hu, Xingchun Gou, Lixian Xu
The mouse is a double transgenic murine model that harbors two transgenes for Alzheimer's Disease (AD)-related mutant proteins. We previously discovered that this double transgenic animal had a premature immunosenescence phenotype. However, it is unclear how this phenotype progresses to a later stage. This study aimed to elucidate the changes in systemic characteristics aside from those associated
-
-
The phagocytosis dysfunction in lupus nephritis is related to monocyte/macrophage CPT1a Immunol. Lett. (IF 4.4) Pub Date : 2024-02-06 Soraya Játiva, Selene Torrico, Priscila Calle, Esteban Poch, Angeles Muñoz, Miriam García, Ana Belén Larque, Maria Teresa Torres Salido, Georgina Hotter
Macrophages must remove apoptotic cells to shield tissues from the deleterious components of dying cells. The development of chronic inflammation and autoimmune symptoms in systemic lupus is influenced by a deficiency in phagocytosis of apoptotic cells but the underlying mechanism is still unknown. Modifications in monocyte/macrophage phenotype brought on by an increase in their inflammatory phenotype
-
In adult X-CGD patients, regulatory T cells are expanded while activated T cells display a NOX2-independent ROS increase Immunol. Lett. (IF 4.4) Pub Date : 2024-02-01 Ilenia Cammarata, Valeria Pinna, Ilenia Pacella, Ivano Rotella, Annarosa Soresina, Raffaele Badolato, Alessandro Plebani, Claudio Pignata, Emilia Cirillo, Anna Maria Zicari, Francesco Violi, Roberto Carnevale, Lorenzo Loffredo, Silvia Piconese
The X-linked chronic granulomatous disease (X-CGD), a rare genetic disease characterised by recurrent infections, is caused by mutations of NOX2. Significant proportions of X-CGD patients display signs of immune dysregulation. Regulatory T cells (Tregs) are CD4 lymphocytes that expand in active inflammation and prevent autoimmune disorders. Here we asked whether X-CGD is associated to Treg dysfunctions
-
IL-38 in Behçet's disease: Gene expression in bronchoalveolar lavage from patients having pulmonary involvement Immunol. Lett. (IF 4.4) Pub Date : 2024-02-01 Kamel Hamzaoui, Sabrine Louhaichi, Mariem Salhi, Fayçal Haj Sassi, Ahmed Laathar, Agnes Hamzaoui
The etiological complexity of Behçet disease (BD), an immune-mediated rare form of vasculitis characterized by multi-organ involvement, is still elusive due to an incomplete understanding of the synergy between genetic susceptibility, environmental triggers, and an abnormal immune response. The diagnosis of BD relies on clinical symptoms. Lung inflammatory disorders are severe conditions of patients
-
Alterations of B-Cell subsets in Peripheral Blood from Adult Patients with Idiopathic Membranous Nephropathy Immunol. Lett. (IF 4.4) Pub Date : 2024-01-24 Huijing Wang, Lan Lan, Jiahui Wang, Jianghua Chen, Liang Xiao, Fei Han
Idiopathic membranous nephropathy (MN) is an autoimmune disease characterized by specific antibodies. However, the underlying mechanisms by which lymphocytes promote the development of MN remain poorly understood. This study aims to determine the changes of B-cell subsets and their clinical significance in MN patients. We included a cohort of 21 idiopathic MN patients with new onset or a relapse, 19
-
The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss Immunol. Lett. (IF 4.4) Pub Date : 2024-01-23 Hamid Ahmadi, Mohammad Sadegh Soltani-Zangbar, Mehdi Yousefi, Behzad Baradaran, Saro Bromand, Leili Aghebati-Maleki, Julia Szekeres-Bartho
Recurrent pregnancy loss (RPL) is a multifactorial disorder, associated with immunologic abnormalities. During pregnancy, the maternal immune system uses different tolerance mechanisms to deal with a semi-allogenic fetus. The expression of immune checkpoints and their related miRNAs in immune cells can ensure pregnancy at the feto-maternal interface by modulating immune responses. This study aims to
-
Could we use PD-1 and PD-L1 expression on lymphocytes and monocytes as predictive markers for prognosis of acute biliary pancreatitis? Immunol. Lett. (IF 4.4) Pub Date : 2024-01-08 Ufuk Oguz Idiz, Basak Aru, Cemal Kaya, Kivanc Derya Peker, Cihad Tatar, Mert Guler, Abdurrahman Tunay, Gulderen Yanikkaya Demirel, Ali Osman Gurol
Purpose This study aimed to assess the significance of immunophenotyping and serum cytokines in predicting the clinical progression of acute biliary pancreatitis (ABP). Materials and methods Cytokine levels, T-helper, cytotoxic T, natural killer (NK) cells, monocytes, HLA-DR, and PD-1, as well as PDL-1 immune checkpoints, were measured in ABP patients at the time of diagnosis and compared with results
-
Expression of epidermal growth factor receptor (EGFR) in systemic sclerosis patients (SSc) and gastro-oesophageal reflux disease (GORD) Immunol. Lett. (IF 4.4) Pub Date : 2024-01-01 Andrea Pasta, Francesco Calabrese, Shirin Djahandideh Sheijani, Manuele Furnari, Edoardo G. Giannini, Federica Grillo, Elisa Marabotto, Luca Mastracci, Giuseppe Murdaca, Simone Negrini, Edoardo Vincenzo Savarino, Vincenzo Savarino, Patrizia Zentilin
Introduction Systemic sclerosis (SSc) affects the connective tissue and leads to an abnormal fibrotic process in the skin and internal organs. Epidermal Growth Factor Receptor (EGFR) is able to induce cell proliferation and differentiation, and its expression is increased in SSc patients with pulmonary artery hypertension and in skin biopsies in patients with scleroderma. To date, no data on esophageal
-
CD36 as a double-edged sword in cancer Immunol. Lett. (IF 4.4) Pub Date : 2023-12-19 Muwei Jiang, Renske Karsenberg, Frans Bianchi, Geert van den Bogaart
The membrane protein CD36 is a lipid transporter, scavenger receptor, and receptor for the antiangiogenic protein thrombospondin 1 (TSP1). CD36 is expressed by cancer cells and by many associated cells including various cancer-infiltrating immune cell types. Thereby, CD36 plays critical roles in cancer, and it has been reported to affect cancer growth, metastasis, angiogenesis, and drug resistance
-
Role of G-protein-coupled estrogen receptor in the pathogenesis of chronic asthma Immunol. Lett. (IF 4.4) Pub Date : 2023-12-22 Masamichi Itoga, Yoshiko Ishioka, Tomonori Makiguchi, Hisashi Tanaka, Kageaki Taima, Norihiro Saito, Hirofumi Tomita, Sadatomo Tasaka
Background and Aim G protein-coupled estrogen receptor (GPER) is an estrogen receptor located on the plasma membrane. We previously reported that the administration of G-1, a GPER-specific agonist, suppressed development of acute ovalbumin (OVA)-induced asthma in a mouse model. Herein, we evaluate the involvement of GPER in a mouse model of chronic OVA asthma. Methods G-1 or saline was administered
-
Adenine is an anti-inflammatory metabolite found to be more abundant in M-CSF over GM-CSF-differentiated human macrophages Immunol. Lett. (IF 4.4) Pub Date : 2023-12-22 Karl J Harber, Thuc-Anh Nguyen, Bauke V Schomakers, Daan A F Heister, Helga E. de Vries, Michel van Weeghel, Jan Van den Bossche, Menno P J de Winther
Immunometabolism has been unveiled in the last decade to play a major role in controlling macrophage metabolism and inflammation. There has been a constant effort to understand the immunomodulating properties of regulated metabolites during inflammation with the aim of controlling and re-wiring aberrant macrophages in inflammatory diseases. M-CSF and GM-CSF-differentiated macrophages play a key role
-
Mechanisms of histamine release from mast cells beyond the high affinity IgE receptor in severe chronic spontaneous urticaria Immunol. Lett. (IF 4.4) Pub Date : 2023-11-30 Riccardo Asero
There is growing evidence suggesting that in a subset of patients with severe chronic urticaria [CSU] mast cells are activated via mechanisms that bypass the high affinity IgE receptor. This might explain why some patients do not respond at all to anti-IgE therapy [omalizumab]. The present article reviews the pathogenic mechanisms able to lead to histamine release from mast cells described so far in
-
Phosphatidylserine promotes immunotherapy for airway allergy Immunol. Lett. (IF 4.4) Pub Date : 2023-11-24 Jinmei Xue, Limin Suo, Yunfang An, Xinxin Wang, Shuang Zhang, Huazhen Liu, Yongjin Wu, Xizhuo Sun, Changqing Zhao, Pingchang Yang
Type 1 regulatory T cells (Tr1 cells) play an important role in the maintenance of the immune homeostasis in the body. The induction of Tr1 cell is to be further investigated. The interaction of phosphatidylserine (PS) with TIM3 has immune regulation functions. The objective of this study is to elucidate the role of PS-TIM3 signals in inducing Tr1 cells. In this study, mice were treated using PS or
-
Platelet dropping, bleeding and new treatment requirements in ITP patients after inactivated COVID-19 vaccination Immunol. Lett. (IF 4.4) Pub Date : 2023-11-24 Xiao-Yong Zhan, Hui Chen, Huimin Kong, Tongfei Meng, Jieyu Ye, Yong Liu, Margaret H.L. Ng, Liang Li, Yuming Zhang, Jinqi Huang, Qiang Peng, Chun Chen, Yulong He, Mo Yang
Significant decreases in platelet counts and ITP relapses have been documented in ITP patients receiving COVID-19 mRNA vaccines; however, the effect of the inactivated COVID-19 vaccine on ITP patients remains unclear. The present study aimed to investigate the impact of inactivated COVID-19 vaccines on ITP patients, with a focus on platelet dropping events, bleeding events/scores, and the requirement
-
Mucosal immunology: Tolerance and inflammation at the gut surface Immunol. Lett. (IF 4.4) Pub Date : 2023-11-17 Thais Garcias Moreira, Ana Maria Caetano Faria
Abstract not available
-
Interleukin-41 as a biomarker of the anti-inflammatory response associated with hyperuricemia Immunol. Lett. (IF 4.4) Pub Date : 2023-11-07 Shujie Zhang, Guoqing Huang, Mingcai Li, Yushan Mao, Yan Li
Background Interleukin (IL)-41 is a recently discovered secreted protein that is expressed in a variety of tissues, and it is associated with several immune and metabolic diseases. However, IL-41 has not been studied in hyperuricemia (HUA). Methods Forty-four HUA patients and 44 healthy controls (HCs) were included in this study, and we collected theirgeneral and biochemical parameters, including white
-
Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability Immunol. Lett. (IF 4.4) Pub Date : 2023-11-10 Yongjie Cai, Ruiqing Yu, Zhanqi Zhang, Di Li, Baicheng Yi, Zhihui Feng, Qiong Xu
-
E3 ligase Nedd4L promotes macrophage M1 polarization and exacerbates brain damage by TRAF3/TBK1 signaling pathway after ICH in mice Immunol. Lett. (IF 4.4) Pub Date : 2023-11-06 Xiaohui Xia, Zhao Yang, Jiangwei Zhang, Xiongjie Fu, Bin Han, Qijiang Xiong, Anyong Yu
Background Intracerebral hemorrhage (ICH) is a serious medical problem, and promising strategy is limited. Macrophage initiated brain inflammatory injury following ICH, but the molecular mechanism had not been well identified. E3 ligase Nedd4L is implicated in the pathogenesis of the inflammatory immune response. Methods In the present study, we detected the levels of Nedd4L in macrophages following
-
The European B cell network Immunol. Lett. (IF 4.4) Pub Date : 2023-11-02 Annemiek B. van Spriel, Rudi W. Hendriks
Abstract not available
-
Activation of cannabinoid receptors 2 alleviates myocardial damage in cecal ligation and puncture-induced sepsis by inhibiting pyroptosis Immunol. Lett. (IF 4.4) Pub Date : 2023-11-02 Jingjing Zhang, Yali Zhu, Shuxian Chen, Zujin Xu, Bin Zhang, Anpeng Liu, Qianwen He, Jia Zhan
Background It has been reported that cannabinoid receptors 2 (CB2 receptors) play an important role in the pathophysiological process of sepsis, which may also be associated with the regulation of pyroptosis, an inflammatory programmed cell death. The present study aimed to investigate the protective effect of CB2 receptors on myocardial damage in a model of septic mice by inhibiting pyroptosis. Methods
-
The SMAC mimetic birinapant alleviates lipopolysaccharide-induced acute lung injury by inhibiting MAPK signaling Immunol. Lett. (IF 4.4) Pub Date : 2023-10-31 Hui Hu, Man Ma, Tao Li, Li Shi, Peizhi Li
The second mitochondria-derived activator of caspases (SMAC) mimetic birinapant attenuated liver injury by inhibited the degradation of tumor necrosis factor receptor-associated factor 3 (TRAF3) and activation of mitogen-activated protein kinase (MAPK) signaling pathway in liver macrophage, but its role in LPS induced acute lung injury (ALI) is not understood. The present study was to investigate the
-
Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice Immunol. Lett. (IF 4.4) Pub Date : 2023-10-22 Hong Liu, Yuxiang Wang, Qingqing Zhang, Chuanchuan Liu, Yougang Ma, Pan Huang, Rili Ge, Lan Ma
-
Thymic atrophy induced by Plasmodium berghei ANKA and Plasmodium yoelii 17XL infection Immunol. Lett. (IF 4.4) Pub Date : 2023-10-22 G.M. Corral-Ruiz, M.J. Pérez-Vega, A. Galán-Salinas, I. Mancilla-Herrera, J. Barrios-Payán, L. Fabila-Castillo, R. Hernández-Pando, L.E. Sánchez-Torres
The thymus is the anatomical site where T cells undergo a complex process of differentiation, proliferation, selection, and elimination of autorreactive cells which involves molecular signals in different intrathymic environment. However, the immunological functions of the thymus can be compromised upon exposure to different infections, affecting thymocyte populations. In this work, we investigated
-
The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells Immunol. Lett. (IF 4.4) Pub Date : 2023-10-20 Yaqin Zhang, Ke Jin, Yan Dai, Nannan Hu, Tingting Zhou, Zhan Yang, Ning Ding, Rui Zhang, Ruowei Xu, Jiaying Zhao, Yaping Han, Chuanlong Zhu, Jin Zhu, Jun Li
Objectives To investigate the changes and mechanism of Siglec-9 on NK cells in peripheral blood of patients with severe fever with thrombocytopenia syndrome (SFTS). Methods First, we used single-cell RNA sequencing to analyze the frequency of NK cells in Peripheral Blood Mononuclear Cells (PBMCs) of SFTS patients and healthy controls (HCs), as well as the differences in the genes on NK cells. Secondly
-
Non-coding RNA and epigenetic regulation in immune cells — Editorial Immunol. Lett. (IF 4.4) Pub Date : 2023-10-11 Jürgen Wittmann, Mir-Farzin Mashreghi
Abstract not available
-
HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function Immunol. Lett. (IF 4.4) Pub Date : 2023-10-12 Syed Bilal Ahmad Andrabi, Kedar Batkulwar, Santosh D. Bhosale, Robert Moulder, Meraj Hasan Khan, Tanja Buchacher, Mohd Moin Khan, Ilona Arnkil, Omid Rasool, Alexander Marson, Ubaid Ullah Kalim, Riitta Lahesmaa
-
Combining local cryoablation with PD-L1 blockade synergistically eradicates established murine lung cancer by modulating mitochondrial in PD-1+CD8+ T cell Immunol. Lett. (IF 4.4) Pub Date : 2023-10-05 Jia-Wei Zhai, Lei-lei Lv, Jia-juan Wu, Yao-xin Zhang, Yu Shen, Qiu-xia Qu, Cheng Chen
Immune checkpoint blockade (ICB) has shown improvement in overall survival for lung cancer in clinical trials. However, monotherapies have limited efficacy in improving outcomes and benefit only a subset of patients. Combination therapies targeting multiple pathways can augment an immune response to improve survival further. Here, we demonstrate that combinatorial anti-PD-L1/cryoablation therapy generated
-
Dextran sulfate sodium-induced gut microbiota dysbiosis aggravates liver injury in mice with S100-induced autoimmune hepatitis Immunol. Lett. (IF 4.4) Pub Date : 2023-10-04 Zi-Ying Wang, Ping-Ping Gao, Ling Li, Ting-Ting Chen, Nan Li, Meng Qi, Sheng-Nan Zhang, Ya-Ping Xu, Yu-Han Wang, Shi-Hao Zhang, Ling-Ling Zhang, Wei Wei, Min Du, Wu-Yi Sun
Recently, the incidence of autoimmune hepatitis (AIH) has gradually increased, and the disease can eventually develop into cirrhosis or even hepatoma if left untreated. AIH patients are often characterized by gut microbiota dysbiosis, but whether gut microbiota dysbiosis contributes to the progression of AIH remains unclear. In this study, we investigate the role of gut microbiota dysbiosis in the
-
Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds Immunol. Lett. (IF 4.4) Pub Date : 2023-09-27 P. Martijn Kolijn, Anton W. Langerak
Lymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment due to its diverse subtypes and underlying mechanisms. This review aims to explore the shared and distinct features of various forms of lymphoma predisposing conditions, with a focus on genetic, immunological and molecular aspects. While diseases such as
-
Vitamin A and vitamin D induced nuclear hormone receptor activation and its impact on B cell differentiation and immunoglobulin production Immunol. Lett. (IF 4.4) Pub Date : 2023-09-27 Padmavathy Ramanarayanan, Guido Heine, Margitta Worm
Vitamin A and vitamin D metabolites are ligands to nuclear receptors – namely RAR, RXR and VDR. The activation of these receptors in human B cells impacts B cell maturation and function. In this review, we discuss how 9-cis retinoic acid (9cRA) and 1,25-dihydroxyvitamin D3 (calcitriol) individually or in conjunction, signal through their nuclear receptors and thereby impact B cell differentiation,
-
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice Immunol. Lett. (IF 4.4) Pub Date : 2023-09-19 Soumalya Banerjee, Prolay Halder, Sanjib Das, Suhrid Maiti, Ushasi Bhaumik, Moumita Dutta, Goutam Chowdhury, Kei Kitahara, Shin-ichi Miyoshi, Asish Kumar Mukhopadhyay, Shanta Dutta, Hemanta Koley
Diarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple
-
-
Single-cell communication patterns and their intracellular information flow in synovial fibroblastic osteoarthritis and rheumatoid arthritis Immunol. Lett. (IF 4.4) Pub Date : 2023-09-12 Jiajian Wang, Caihong Liu, Tingting Wang, Sidi Li, Yunmeng Bai, Fulin Pan, Jiayi Wang, Jing Han, Ruibin Luo, Xing Wan, Haiyan Cui, Yingcai Huang, Mingqi Zheng, Xiaoping Hong, Jian V. Zhang, Ruihuan Xu
-
A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation Immunol. Lett. (IF 4.4) Pub Date : 2023-09-16 Jin-Sil Park, SeungCheon Yang, Doona Song, Sung-Min Kim, JeongWon Choi, Hye Yeon Kang, Ha Yeon Jeong, Gyoonhee Han, Do Sik Min, Mi-La Cho, Sung-Hwan Park
Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays multiple roles in inflammation. We investigated the therapeutic effects of the newly developed PLD1 inhibitors A2998, A3000, and A3773 in vitro and in vivo rheumatoid arthritis (RA) model. A3373 reduced the levels of LPS-induced TNF-α, IL-6, and IgG in murine splenocytes in vitro.
-
Autophagy and LC3-associated phagocytosis contribute negatively to the killing capability of THP-1-derived macrophages against Candida albicans at the mid-stage Immunol. Lett. (IF 4.4) Pub Date : 2023-09-16 Ding Li, Lin Wang, Zhihong Zhao, Changsen Bai, Xichuan Li
In innate immunity, macrophages play critical roles in defending against pathogens via the lysosomal degradation function of autophagy. Two distinct autophagy pathways have been identified in decades: canonical autophagy (referred to as autophagy) and LC3-associated phagocytosis (LAP). Since several conflicting findings about the anti-Candida capability of autophagy (or LAP) have been reported, they
-
Rho-kinase inhibitors to deplete age-associated B cells in systemic autoimmunity Immunol. Lett. (IF 4.4) Pub Date : 2023-09-07 Athanasios Sachinidis, Alexandros Garyfallos
Abstract not available
-
Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model Immunol. Lett. (IF 4.4) Pub Date : 2023-09-07 Na Lu, Jun-fan Zhu, He-fan Lv, Hai-peng Zhang, Peng-le Wang, Jing-jing Yang, Xian-wei Wang
Objective Efferocytosis dysfunction contributes to the progression and rupture of atherosclerotic plaques. Efferocytosis is crucially modulated by intracytoplasmic Ca2+, and mitochondrial calcium uniporter (MCU) complex proteins serve as key channels for regulating Ca2+ concentration. Therefore, it was speculated that MCU may affect the development of atherosclerosis (AS) by regulating efferocytosis
-
Use of recombinant S1 protein with hFc for analysis of SARS-CoV-2 adsorption and evaluation of drugs that inhibit entry into VERO E6 cells Immunol. Lett. (IF 4.4) Pub Date : 2023-09-06 Jéssica Carla Martins Couto, Taís Vidal, Eduardo Reichert Decker, Janio M Santurio, Carlos Fernando Mello, Micheli Mainardi Pillat
The significant number of deaths and infection caused by the new coronavirus SARS-CoV-2 has created an urgent demand for effective and readily available drugs for the treatment of COVID-19. However, the requirements for biosafety level 3 (NB-3) laboratories for experiments with the virus has made it very challenging for such research to meet this demand. It is known that angiotensin-converting enzyme
-
Leveraging microRNAs for cellular therapy Immunol. Lett. (IF 4.4) Pub Date : 2023-09-03 Marko Hasiuk, Marianne Dölz, Romina Marone, Lukas T. Jeker
-
Bothrops jararacussu snake venom decreases CD1d, CD83, and CD86 expression on bone marrow-derived dendritic cells Immunol. Lett. (IF 4.4) Pub Date : 2023-08-26 N.M. Nery, H.M. Santana, C.M.A. Rego, J.A. Lopes, M.D.S. Silva, A.A. Ferreira e Ferreira, V.P. Reis, M.V. Paloschi, S.N. Serrath, J.S.F. Bastos, C.P. Silva, J.G.S. Magalhães, L.F. Cruz, S.S. Setubal, J.P. Zuliani
This study was designed to characterize mice bone marrow (BM) and bone marrow-derived dendritic cells (BMDC) and to compare the surface markers expression and inflammatory cytokine liberation in response to LPS and Bothrops jararacussu venom (BjV) stimulation. Typical morphology was observed in BM and BMDCs from the 4th up to the 8th day of culture using recombinant mouse GM-CSF and IL-4. A high basal
-
Enhanced immunoprotection against Acinetobacter baumannii infection: Synergistic effects of Bap and BauA in a murine model Immunol. Lett. (IF 4.4) Pub Date : 2023-08-29 Mobina Mansouri, Masoomeh Sadeghpoor, Abolfazl Jahangiri, Mohammad Hossein Ghaini, Iraj Rasooli
Background The rise of multi-drug resistant Acinetobacter baumannii poses a grave threat to hospital settings, resulting in increased mortality rates and garnering global attention. The formation of biofilms facilitated by biofilm-associated protein (Bap) and the iron absorption capabilities mediated by Baumannii acinetobactin utilization A (BauA) contribute to the persistence and survival of multidrug-resistant
-
Pre-infection antibody levels of vaccinated healthcare workers with SARS-CoV-2 breakthrough infection: A nested case-control study Immunol. Lett. (IF 4.4) Pub Date : 2023-08-18 Sema Alp Çavuş, Muammer Çelik, Ahmet Furkan Süner, Irmak Güzel, Çağlar Irmak, Derya Çağlayan, Huriye Gamze Öztürk, Neslişah Şiyve, Özgür Appak, Elif Işık, Gül Ergör, Osman Alparslan Ergör, Yücel Demiral, Ayça Arzu Sayıner, Bülent Kılıç
Aim To evaluate anti-RBD IgG antibody levels and neutralizing antibody titers between the health care workers (HCWs) with breakthrough SARS-CoV-2 infection and controls. Methods In this nested case-case control study, we followed 548 vaccinated HCWs with homologous (only with inactivated vaccine) or heterologous (both with inactivated and BNT162b2 vaccine) vaccination for 11 months, prospectively.
-
Elevated circulating CD19+CD24hiCD38hi B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy Immunol. Lett. (IF 4.4) Pub Date : 2023-08-06 Bishun Deng, Li Deng, Miao Liu, Ziling Zhao, Huijie Huang, Xiaoxin Tu, Enyu Liang, Ruimin Tian, Xiaowan Wang, Rongrong Wang, Haibiao Lin, Yongyi Yu, Anping Peng, Peng Xu, Kun Bao, Min He
CD19+CD24hiCD38hi regulatory B cells exert immunosuppressive functions by producing IL-10, but their role in idiopathic membranous nephropathy (IMN) remains elusive. Here, we investigated the frequency and functional changes of circulating CD19+CD24hiCD38hi B cells and evaluated the correlation of CD19+CD24hiCD38hi B cells with clinical features and T helper cell subsets in IMN patients. Compared with
-
Corrigendum to “Identification and suppression of epidermal growth factor receptor variant III signaling in fibroblast-like synoviocytes from aggressive rheumatoid arthritis by the mimotope” [Immunology Letters 198 (2018) 74–80] Immunol. Lett. (IF 4.4) Pub Date : 2023-08-08 Jianying Niu, Changhong Li, Yinji Jin, Rui Xing, Lin Sun, Ruohan Yu, Leilei Jian, Xiangyuan Liu, Lin Yang
Abstract not available
-
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways Immunol. Lett. (IF 4.4) Pub Date : 2023-07-28 Negar Farzam-kia, Ana Carmena Moratalla, Florent Lemaître, Annie Levert, Sandra Da Cal, Clara Margarido, Yves Carpentier Solorio, Nathalie Arbour
Human monocytes and macrophages are two major myeloid cell subsets with similar and distinct functions in tissue homeostasis and immune responses. GM-CSF plays a fundamental role in myeloid cell differentiation and activation. Hence, we compared the effects of GM-CSF on the expression of several immune mediators by human monocytes and monocyte-derived macrophages obtained from healthy donors. We report
-
Corrigendum to “Interleukin-40 is a promising biomarker associated with type 2 diabetes mellitus risk” [Immunology Letters 254 (2023) 1–5] Immunol. Lett. (IF 4.4) Pub Date : 2023-07-18
Abstract not available
-
Disturbance in the reconstitution of distinct T-cell subsets and the incidence of GvHD following allo-HSCT in pediatric patients with non-malignant hematological disorders Immunol. Lett. (IF 4.4) Pub Date : 2023-07-18 Shideh Namazi Bayegi, Amir Ali Hamidieh, Maryam Behfar, Mahmood Bozorgmehr, Amene Saghazadeh, Nader Tajik, Ali-Akbar Delbandi, Farzaneh Tofighi Zavareh, Samaneh Delavari, Mehdi Shekarabi, Nima Rezaei
Background The reconstitution of different T-cell subsets following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is critical for efficient pathogen protection and the prevention of graft-versus-host disease (GvHD). In particular, studies have highlighted the importance of balanced ratios of regulatory T-cells (Tregs) and distinct functionally T-cells in preventing acute and chronic
-
Distribution of peripheral blood mononuclear cell subtypes in patients with West syndrome: Impact of synacthen treatment Immunol. Lett. (IF 4.4) Pub Date : 2023-07-17 Selen Soylu, Minara Cherkezzade, Ece Akbayır, Hande Yüceer Korkmaz, Gizem Koral, Elif Şanlı, Pınar Topaloğlu, Vuslat Yılmaz, Erdem Tüzün, Cem İsmail Küçükali
Background West Syndrome (WS) is an epileptic encephalopathy that typically occurs in infants and is characterized by hypsarrhythmia, infantile spasms, and neurodevelopmental impairment. Demonstration of autoantibodies and cytokines in some WS patients and favorable response to immunotherapy have implicated inflammation as a putative trigger of epileptiform activity in WS. Our aim was to provide additional
-
The miR-142 miRNAs: Shaping the naïve immune system Immunol. Lett. (IF 4.4) Pub Date : 2023-07-17 William J. Olson, Emmanuel Derudder
Immunity in a naïve organism is tightly controlled. Adequate proportions of the many immune cell subsets must be produced to mount efficient responses to eventual challenges. In addition, a functioning immune system is highly dynamic at steady state. Mature immune cells must be positioned properly and/or circulate to facilitate the detection of dangers. They must also be poised to promptly react to
-
Human toll-like receptor 8 (TLR8) in NK cells: Implication for cancer immunotherapy Immunol. Lett. (IF 4.4) Pub Date : 2023-07-13 Irene Veneziani, Claudia Alicata, Lorenzo Moretta, Enrico Maggi
Toll-like receptors (TLR)s are homo- or heterodimeric proteins, whose structure and function were widely described in the antigen presenting cells (APC), such as Dendritic cells (DC). Recently, the expression and the role of TLRs in fighting against pathogens, was described also in NK cells. Their activation and functional properties can be directly and indirectly modulated by agonists for TLRs. In
-
Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases Immunol. Lett. (IF 4.4) Pub Date : 2023-07-13 Laurens Bogers, Kirsten L. Kuiper, Joost Smolders, Jasper Rip, Marvin M. van Luijn
B cells expressing the transcription factor T-bet are found to have a protective role in viral infections, but are also considered major players in the onset of different types of autoimmune diseases. Currently, the exact mechanisms driving such ‘atypical’ memory B cells to contribute to protective immunity or autoimmunity are unclear. In addition to general autoimmune-related factors including sex
-
Human and mouse early B cell development: So similar but so different Immunol. Lett. (IF 4.4) Pub Date : 2023-07-11 Jakov Korzhenevich, Iga Janowska, Mirjam van der Burg, Marta Rizzi
Early B cell development in the bone marrow ensures the replenishment of the peripheral B cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process guided by an intricate network of transcription factors as well as chemokine and cytokine signals. Humans and mice possess somewhat similar regulatory mechanisms of B lymphopoiesis. The continuous discovery of monogenetic
-
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis Immunol. Lett. (IF 4.4) Pub Date : 2023-07-04 Chris Myllynen, Joona Sarkkinen, Sari Atula, Pentti Tienari, Eliisa Kekäläinen, Sini M. Laakso
Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular disease with an unpredictable clinical course. Serum free light chains (FLCs) have risen as a promising biomarker for MG, but their role in different subtypes of MG and in predicting disease progression is still uncharted. We investigated plasma from 58 generalized MG patients during post-thymectomy follow-up to determine κ and λ FLC
-
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice Immunol. Lett. (IF 4.4) Pub Date : 2023-06-25 Youjiao Huang, Feng Han, Jiaju Li, Yuandi Li, Jie Gao, Laijun Lai, Peng Luo, Min Su, Rong Hu
Pathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant
-
Building the synapse engine to drive B lymphocyte function Immunol. Lett. (IF 4.4) Pub Date : 2023-06-25 Yolanda R. Carrasco
B cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and drives the humoral immune response. This enables the generation of antibody-producing plasma cells, the effector arm of the B cell immune response, and of memory B cells, which confer protection against additional encounters with antigen. B cells search for cognate antigen in the complex cellular microarchitecture
-
Serum profiles of pro-inflammatory and anti-inflammatory cytokines in non-hospitalized patients with mild/moderate COVID-19 infection. Immunol. Lett. (IF 4.4) Pub Date : 2023-06-18 Abdulraheem Y. Majeed, Nor Effa S. Zulkafli, Ali H. Ad'hiah
This study attempted to explore pro-inflammatory and anti-inflammatory responses in patients with mild/moderate coronavirus disease 19 (COVID-19). Eight pro-inflammatory (IL-1α, IL-1β, IL-12, IL-17A, IL-17E, IL-31, IFN-γ and TNF-α) and three anti-inflammatory (IL-1Ra, IL-10 and IL-13) cytokines, as well as two chemokines (CXCL9 and CXCL10), were analyzed in the serum from ninety COVID-19 patients and
-
A new experimental model to study shrimp allergy Immunol. Lett. (IF 4.4) Pub Date : 2023-06-13 Ivanéia Valeriano Nunes, Camila Mattos Andrade, Priscila Valera Guerra, Mariana Ivo Khouri, Maria Poliana Leite Galantini, Robson Amaro Augusto da Silva, Eliana L. Faquim-Mauro, Leonardo Paiva Farias, Juliana de Souza Rebouças, Ana Maria Caetano Faria, Cláudia Ida Brodskyn
Shrimp is among the most sensitizing food allergens and has been associated with many anaphylaxis reactions. However, there is still a shortage of studies that enable a systematic understanding of this disease and the investigation of new therapeutic approaches. This study aimed to develop a new experimental model of shrimp allergy that could enable the evaluation of new prophylactic treatments. BALB/c