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Altered Immune Regulation of Dendritic Cells and Enhanced Cytokine Production of T Cells in the Pathogenesis of Eosinophilic Chronic Rhinosinusitis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-25 Kaori Kawakami; Tomomitsu Miyasaka; Isao Ohno; Nobuo Ohta; Chiaki Masuda-Suzuki; Yutaka Tateda; Yusuke Kusano; Fumi Shoji; Shiori Kitaya; Yutaka Nakamura; Tomohiro Arikawa; Tasuku Kawano; Motoaki Takayanagi; Tomoko Takahashi
Introduction: Eosinophilic chronic rhinosinusitis (ECRS) is a refractory chronic disease defined by recurrent nasal polyps with severe eosinophilic infiltration. This is mainly due to enhanced type 2-dominant immune responses, but the underlying mechanism is still not fully understood. Objective and Methods: In the present study, we aimed to determine the characteristics of dendritic cells (DCs) and
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The Ability to Use Epinephrine Autoinjector in Patients Who Receive Prescription Immediately after Anaphylaxis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-22 Saša Kadivec; Mitja Košnik
Background: Epinephrine autoinjector (EAI) is prescribed to prevent a fatal outcome in the case of a repeated anaphylactic reactions. We wanted to determine how adult patients who received their first prescription as part of an urgent treatment of an anaphylactic reaction or at their family physician were instructed on the use of EAI. Methods: Nurses assessing patients’ knowledge asked the patient
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Interleukin-8 Levels in the Stratum Corneum as a Biomarker for Monitoring Therapeutic Effect in Atopic Dermatitis Patients Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-22 Susumu Murata; Sakae Kaneko; Eishin Morita
Introduction: The stratum corneum contains several growth factors and cytokines that are synthesized in keratinocytes. We previously reported that the amount of interleukin-8 in the stratum corneum (scIL-8) is related to the severity of local skin inflammation in atopic dermatitis (AD). However, it is unknown whether scIL-8 levels reflect pharmacologic responses to a therapeutic intervention in AD
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SARS-CoV-2-Associated T-Cell Responses in the Presence of Humoral Immunodeficiency Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-22 Sudhir Gupta; Houfen Su; Tejal Narsai; Sudhanshu Agrawal
We report perhaps the most comprehensive study of subsets of CD4+ and CD8+ and subsets of B cells in a mild symptomatic SARS-CoV-2+ immunocompetent patient and a common variable immunodeficiency disease (CVID) patient who had normal absolute lymphocyte counts and remained negative for SARS-CoV-2 IgG antibodies. Naïve (TN), central memory (TCM), effector memory (TEM), and terminally differentiated effector
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Downregulation of miR-96-5p Inhibits mTOR/NF-κb Signaling Pathway via DEPTOR in Allergic Rhinitis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-21 Jia-Bin Zhan; Jing Zheng; Lian-Ya Zeng; Zhi Fu; Qiu-Ju Huang; Xin Wei; Min Zeng
Background: This study aims to investigate the regulatory effect of microRNA-96-5p (miR-96-5p) in the pathophysiological process of allergic rhinitis (AR). Methods: Nasal mucosal tissue samples were collected from AR patients and healthy controls. An in vitro AR model was established by stimulating human nasal epithelial cells (HNECs) with interleukin (IL)-13. The expressions of target genes and proteins
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Acquired Angioedema with C1 Inhibitor Deficiency: Occurrence, Clinical Features, and Management: A Nationwide Retrospective Study in the Czech Republic Patients Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-20 Marta Sobotkova; Radana Zachova; Roman Hakl; Pavel Kuklinek; Pavlina Kralickova; Irena Krcmova; Jana Hanzlikova; Martina Vachova; Jirina Bartunkova
Introduction: Acquired angioedema with C1 inhibitor deficiency (AAE-C1-INH) is rare but a potentially life-threatening disease. There are no official prevalence data, nor approved therapies for this condition. Objective: In this study, we aimed to collect and analyze clinical data on patients with AAE-C1-INH in the Czech Republic. Methods: We have conducted a retrospective analysis of AAE-C1-INH patients
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Ole e 3, a Candidate for in vivo Diagnosis of Polcalcin Sensitization Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-18 Raquel Moya; Azahara González-Ruiz; Juan María Beitia; Jerónimo Carnés; María Ángeles López-Matas
Introduction: Polcalcins belong to the family of calcium-binding proteins. They are ubiquitous in the plant kingdom and highly conserved, which leads to these panallergens showing a high degree of inter-cross-reactivity. They are responsible for allergic polysensitization, and therefore, their diagnosis is necessary for correct selection of immunotherapy. The objectives were to develop a method to
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Lower Cord Blood IL-17 and IL-25, but Not Other Epithelial Cell-Derived Cytokines Are Associated with Atopic Dermatitis in Infancy Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2021-01-07 Cristina Gamez; Jessica Metcalfe; Susan L. Prescott; Debra J. Palmer
Background: There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards “at-risk” infants. Objectives: The aim of this longitudinal investigation
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Lentinan Inhibited the Activation of Th2 Cells in Allergic Mice by Reducing the Amplitude of Changes in Biological Rhythm Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-30 Shuai Yang; Huifang Chew; Yuchi Jiang; Lei Cheng; Xiaoya Guo; Huilian Che; Na Sun
Introduction: Biological rhythm is inextricably linked to the physiological mechanisms of allergic diseases, but the exact mechanisms are still poorly understood. Clinical studies have reported rhythmic fluctuations in allergic diseases. The search for natural and harmless active ingredients based on biological rhythm with which to regulate allergic diseases is essential for the control of food allergy
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Spices to Control COVID-19 Symptoms: Yes, but Not Only… Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-22 Jean Bousquet; Wienczyslawa Czarlewski; Torsten Zuberbier; Joaquim Mullol; Hubert Blain; Jean-Paul Cristol; Rafael De La Torre; Vincent Le Moing; Nieves Pizarro Lozano; Anna Bedbrook; Ioana Agache; Cezmi A. Akdis; G. Walter Canonica; Alvaro A. Cruz; Alessandro Fiocchi; Joao A. Fonseca; Susana Fonseca; Bilun Gemicioğlu; Tari Haahtela; Guido Iaccarino; Juan Carlos Ivancevich; Marek Jutel; Ludger Klimek;
There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2
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Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-18 Maria Ruano-Zaragoza; Maria Luisa Somoza; Teodorikez Wilfox Jiménez-Rodriguez; Victor Soriano-Gomis; Purificación González-Delgado; Angel Esteban-Rodriguez; Antonio Palazón-Bru; Miguel Blanca; Javier Fernández-Sánchez
Background: Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. Objective: The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the
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Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-16 Zhenli Huang; Bohua Fu; Xuefei Qi; Yuzhu Xu; Yong Mou; Min Zhou; Yong Cao; Guorao Wu; Jungang Xie; Jianping Zhao; Yi Wang; Weining Xiong
Introduction: Circular RNAs (circRNAs) are an endogenous mircoRNA sponge that could act as potential biomarkers for the diagnosis and treatment of diseases. However, the role of circRNAs in asthma is far from clear. Objective: The aim of this study is to assess the diagnostic and therapeutic value of hsa_circ_0002594 for T helper (Th) 2-mediated allergic asthma. Methods: The expression profiles of
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High-Dose Omalizumab versus Ligelizumab for the Treatment of Chronic Spontaneous Urticaria: Do Not We Need a Head-To-Head Comparison? Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-15 Murat Türk; İnsu Yılmaz
Int Arch Allergy Immunol
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Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned? Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-15 Camila Marques de Valois Lanzarin; Natalia de Oliveira e Silva; Maissara Obara Venturieri; Dirceu Solé; Ricardo Palmero Oliveira; Vera Lucia Sdepanian
Background: Concomitance of celiac disease (CD) and IgE-mediated wheat allergy is described in some case reports. The objective was to evaluate the frequency of sensitization to wheat, rye, barley, and malt in children and adolescents with CD. Methods: Measurement of serum levels of specific IgE to wheat, rye, barley, and malt (ImmunoCAP; sensitization IgE ≥0.35 kUA/L) in CD patients followed in specialized
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Grains of Wisdom: Transgenic Rice for Oral Allergen Immunotherapy in Japanese Cedar Pollen-Allergic Patients Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-15 Carla Irani; Angela Haczku
Int Arch Allergy Immunol
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Investigation of Allergic Sensitization Pattern in 4,203 Children in Northern China Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-09 Wei Wang; Xian-hui Zhang; Lei Zhu; Yu-xiang Liu
Objective: The objective of this study is to investigate the allergen sensitization pattern among 4,203 children in the Shanxi region of China and to provide guidance for diagnosis and prevention of allergic diseases. Methods: A retrospective analysis was conducted on the allergen-specific immunoglobulin E (sIgE) results of 4,203 children aged 0–12 years from January to December in 2019. SIgE antibodies
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Associations between Polymorphisms in the IL-1 Gene and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Evidence from a Meta-Analysis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-07 Lin Zhu; Peng Chen; Xuanjing Sun; Shuo Zhang
Background: Previous studies on polymorphisms in interleukin-1 (IL-1) and the risk of rheumatoid arthritis (RA)/systemic lupus erythematosus (SLE) yielded inconsistent results. Objectives: The authors performed this meta-analysis to more robustly evaluate associations between polymorphisms in the IL-1 gene and the risk of RA/SLE. Methods: MEDLINE, Embase, Web of Science, Wanfang, VIP, and CNKI were
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Cytokine Polymorphisms and Predisposition to Diabetic Nephropathy: A Meta-Analysis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-07 Suqin Wang; Jiazhi Dong; Lingling Huang
Background: Cytokine polymorphismsmight influence the predisposition to diabetic nephropathy (DN), but the results of already published related studies are still controversial and ambiguous. Objectives: The authors designed this meta-analysis to more precisely estimate relationships between TNF-α/IL-1/IL-4/IL-8/IL-18polymorphisms and DN by pooling the results of already published related studies. Methods:
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SELE Downregulation Suppresses Mast Cell Accumulation to Protect against Inflammatory Response in Chronic Idiopathic Urticaria Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-07 Hong Wang; Yangchun Xu; Meishan Jin; Wen Yuan
Background:Chronic idiopathic urticaria (CIU) represents a common skin disorder often characterized by mast cell activation and secretion of histamine and other proinflammatory factors. E-selectin (SELE) has been implicated in the pathogenesis of common inflammatory cutaneous disorders, while the role of SELE in CIU is yet to be fully understood. Thus, we aimed to investigate the mechanism by which
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Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-02 Elide Anna Pastorello; Linda Borgonovo; Donatella Preziosi; Jan Walter Schroeder; Valerio Pravettoni; Maria Gloria Aversano; Stefano Pastori; Maria Beatrice Bilò; Marta Piantanida; Laura Michelina Losappio; Michele Nichelatti; Carlo Maria Rossi; Laura Farioli
Introduction: Allergy to Hymenoptera venom (HV) may lead to life-threatening anaphylaxis. Some of the factors influencing the symptom’s severity are still undetermined. The aim of this study was to identify the clinical aspects associated with the most severe reactions in a population with HV allergy, by comparing clinical and immunochemical biomarkers between patients with previous local large reactions
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Acknowledgement to the Reviewers Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-01
Int Arch Allergy Immunol 2020;181:966–968
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Contents Vol. 181, 2020 Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-12-01
Int Arch Allergy Immunol 2020;181:I–X
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Erratum Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-23 H.-U. Simon; Rudolf Valenta; Barbara Bohle; A. Wesley Burks; Ruby Pawankar; Andreas Radbruch; Hirohisa Saito; Carsten B. Schmidt-Weber; Thomas Schwarz; Wayne Thomas; Massimo Triggiani; Verena Niederberger-Leppin; Paul M. O'Byrne; Winfried F. Pickl; Motohiro Ebisawa; Thilo Jakob; Ronald van Ree; Holger Garn; Philippe Gevaert; David Dombrowicz; Federica Sallusto; Tak H. Lee; M. Triggiani; Kurt Blaser;
Int Arch Allergy Immunol
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Presence of Tertiary Lymphoid Organ in Nasal Inverted Papilloma Is Correlated with Eosinophil Infiltration and Local Immunoglobulin Production Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-18 Qing Bao; Xue-Xue Guo; Chen Cao; Qian-Ying Li; Lin Sun; Xiao-Yan Ye; Li-Yue Li; Jun-Chao Dong; Yi-Fang Gao; He-Xin Chen; Chun-Wei Li
Introduction: Nasal inverted papilloma (NIP) is a benign tumour with multiple inflammatory cell infiltration. Tertiary lymphoid organs (TLOs) support local antibody production and play important roles in airway inflammation. However, the evidence of TLOs and local immunoglobulins in NIP has not been reported yet. We investigated the presence of TLOs and immunoglobulins in NIP tissues and their association
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Gene Expression Analysis by Real-Time PCR in Nasal Brushings of Adult Patients with Allergic Rhinitis, Suspected Allergic Rhinitis, and Nonallergic Rhinitis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-10 Min Wang; Wenyu She; Jun Yang; Xiangdong Wang; Yuan Zhang; Xu Zhang; Luo Zhang
Background: Epithelial gene expression in allergic rhinitis patients has been evaluated by microarray. However, gene expression in patients with nonallergic rhinitis and suspected allergic rhinitis who reported allergen-related nasal symptoms but presented a negative atopic test was unknown. Objectives: The aim of this study was to observe and compare epithelial gene expression in patients with allergic
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Aggravation of Food Allergy by Skin Sensitization via Systemic Th2 Enhancement Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-11 Risa Koshiba; Takafumi Oba; Arisa Fuwa; Katsuhiko Arai; Nobumitsu Sasaki; Genki Kitazawa; Makoto Hattori; Hiroshi Matsuda; Tadashi Yoshida
Background: Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. Objective: To examine the effect of sensitization in healthy skin on IgE and cytokine production during food allergy development. Methods: The effect of
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Factors Influencing Total Serum IgE in Adults: The Role of Obesity and Related Metabolic Disorders Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-11 Iago Carballo; Manuela Alonso-Sampedro; Elena Gonzalez-Conde; Juan Sanchez-Castro; Carmen Vidal; Francisco Gude; Arturo Gonzalez-Quintela
Background and Aim: Few reports have investigated the association between metabolic abnormalities (obesity and related metabolic syndrome) and total serum IgE concentrations. Methods: This cross-sectional study included a random sample of 1,516 adult individuals (44.7% men, aged 18–91 years, median 52 years) from a single municipality in Spain. Serum IgE was measured in the ADVIA Centaur system. Atopy
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Intralymphatic Administration of Metagonimus yokogawai-Extracted Protein Attenuates Experimental Murine Allergic Rhinitis Model Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-11 Hyung Chae Yang; Eun Jeong Won; Moon-Ju Kim; Chung Man Sung; Joon Haeng Rhee; Kwang Il Nam
Objectives: This study aimed to evaluate potential therapeutic effect of Metagonimus yokogawai on the OVA-induced allergic rhinitis model. Methods: OVA-sensitized mice were used to assess potential therapeutic effect of the extract protein of M. yokogawai (My-TP). My-TP was administrated via the intralymphatic route to cervical lymph nodes. The frequencies of sneezing or nasal rubbing were recorded
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Upregulated ox40l Can Be Inhibited by miR-146a-5p in Condylar Chondrocytes Induced by IL-1β and TNF-α: A Possible Regulatory Mechanism in Osteoarthritis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-04 Ding Yu; Wang Wei; Yang Hefeng; Li Weihao; Qu Qianqian; Li Song
Introduction: Osteoarthritis (OA) is a common musculoskeletal disease characterized by pain, stiffness, limited activity, occasional effusion, and local inflammation. MiR-146 is one of the noncoding RNA closely related to OA, but the role of miR-146 in OA remains controversial. The tumour necrosis factor receptor OX40 is activated by its cognate ligand OX40L (TNFSF4) and functions as a T-cell costimulatory
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Lactococcus lactis NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-11-04 Daniel Cervantes-García; Mariela Jiménez; César E. Rivas-Santiago; Pamela Gallegos-Alcalá; Alicia Hernández-Mercado; Leslie S. Santoyo-Payán; María de Jesús Loera-Arias; Odila Saucedo-Cardenas; Roberto Montes de Oca-Luna; Eva Salinas
Introduction: The use of probiotics has been broadly popularized due to positive effects in the attenuation of aberrant immune responses such as asthma. Allergic asthma is a chronic respiratory disease characterized by airway inflammation and remodelling. Objective: This study was aimed to evaluate the effect of oral administration of Lactococcus lactis NZ9000 on asthmatic airway inflammation and lung
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Mepolizumab Effectiveness and Allergic Status in Real Life Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-28 Bruno Sposato; Marco Scalese; Gianna Camiciottoli; Giovanna Elisiana Carpagnano; Corrado Pelaia; Pierachille Santus; Mauro Maniscalco; Angelo Corsico; Amelia Grosso; Stefano Baglioni; Nicola Murgia; Ilenia Folletti; Girolamo Pelaia; Simonetta Masieri; Carlo Cavaliere; Antonino Musarra; Elena Bargagli; Alberto Ricci; Manuela Latorre; Pierluigi Paggiaro; Paola Rogliani
Background: It is not clear whether mepolizumab is differently effective in allergic and nonallergic severe eosinophilic asthmatics (SEA) in real life. Objective: We tested mepolizumab effectiveness in allergic/nonallergic SEA in real life. A strict criterion to identify the 2 phenotypes was used. Method: We retrospectively considered 134 consecutive patients divided into allergic, with a positivity
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Recent Practice Patterns and Variations in Children Hospitalized for Asthma Exacerbation in Japan Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-22 Yusuke Okubo; Kenta Horimukai; Nobuaki Michihata; Kojiro Morita; Hiroki Matsui; Kiyohide Fushimi; Hideo Yasunaga
Background: High antibiotic prescribing rates for adults with an asthma exacerbation have been reported in developed countries, but few studies have assessed the variation of antibiotic and adjunctive treatment in the routine care of children. Objective: We evaluated the trends in health resource utilization for children hospitalized for asthma exacerbation, ascertained the variations of practices
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The Protective Effects of Helicobacter pylori Infection on Allergic Asthma Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-20 Zhi Tong Zuo; Ya Ma; Yan Sun; Cui Qing Bai; Chun Hua Ling; Feng Lai Yuan
As an ancient Gram-negative bacterium, Helicobacter pylori has settled in human stomach. Eradicating H. pylori increases the morbidities of asthma and other allergic diseases. Therefore, H. pylori might play a protective role against asthma. The “disappearing microbiota” hypothesis suggests that the absence of certain types of the ancestral microbiota could change the development of immunology, metabolism
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Change in Allergy Practice during the COVID-19 Pandemic Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-15 Ayse Bilge Ozturk; Ayşe Baççıoğlu; Ozge Soyer; Ersoy Civelek; Bülent Enis Şekerel; Sevim Bavbek
Background: International guidelines in asthma and allergy has been updated for COVID-19 pandemic and pandemic has caused dramatic changes in allergy and immunology services. However, it is not known whether specialty-specific recommendations for COVID-19 are followed by allergists. Objectives: By conducting this study, we aimed to determine the attitudes and experiences of adult/pediatric allergists
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Chronic Granulomatous Disease: A Perspective from a Developing Nation Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-15 Sathish Kumar Loganathan; Pandiarajan Vignesh; Rakesh Kumar Pilania; Amit Rawat; Surjit Singh
Int Arch Allergy Immunol
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Reconstitution of IgG Subclasses Following Immunoglobulin Administration in Adult Patients with Common Variable Immune Deficiency Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-14 David Reeder; Sudhir Gupta
Background: Immunoglobulin (Ig) therapy reduces the frequency and severity of infection among patients with antibody deficiency disorders. However, a subset of patients lacks adequate clinical response. Objective: The purpose of this study was to determine in adult common variable immune deficiency (CVID) patients (A) if lack of clinical response to Ig therapy correlates with lack of reconstitution
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Baked Tolerance in Cow’s Milk Allergy: Quite Frequent, Hard to Predict! Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-14 Lisis Karine Vilar; Flávia Alves Araújo; Thalita Pereira Santos; Thatiana Tavares Menezes; Marina F. Cheik; Gesmar Rodrigues Silva Segundo
Introduction: Cow’s milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. Objective: The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for different cow’s milk (CM) protein types as predictors of tolerance to baked foods containing
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Comment on: Predictive and Diagnostic Value of Nasal Nitric Oxide in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-08 Siamak Sabour
Int Arch Allergy Immunol
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Formation of IgE-Allergen-CD23 Complex Changes in Children Treated with Subcutaneous Immunotherapy for Japanese Cedar Pollinosis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-08 Tomoyuki Asaumi; Sakura Sato; Noriyuki Yanagida; Hiroki Matsuhara; Satoko Kobayashi; Chiharu Fukano; Katsuyo Ohashi-Doi; Motohiro Ebisawa
Background: Subcutaneous immunotherapy (SCIT) is used to treat Japanese cedar (JC) pollinosis. The formation of IgE-allergen-CD23 complex after SCIT for JC pollinosis has not yet been fully elucidated. Objective: The objective of this study was to investigate the formation of IgE-allergen-CD23 complex after SCIT for JC pollinosis. Methods: Eleven patients were treated with 3-year SCIT for JC pollinosis
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Evaluation of the Diagnostic Accuracy of Thymus and Activation-Regulated Chemokine to Discriminate Food Protein-Induced Enterocolitis Syndrome from Infectious Gastroenteritis Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-10-06 Eishi Makita; Sae Kuroda; Kae Itabashi; Daisuke Sugawara; Ko Ichihashi
Background: Post-emetic elevation in thymus and activation-regulated chemokine (TARC) levels has been reported in patients with food protein-induced enterocolitis syndrome (FPIES); however, no studies have investigated differences in TARC levels between FPIES and other diseases. Objectives: We evaluated the clinical usefulness of TARC measurement in differentiating between FPIES and infectious gastroenteritis
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The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-24 Annabelle M Watts,Nicholas P West,Ping Zhang,Peter K Smith,Allan W Cripps,Amanda J Cox
Introduction: Unique gut microbial colonisation patterns are associated with the onset of allergic disease in infants; however, there is insufficient evidence to determine if aberrant microbial composition patterns persist in adult allergic rhinitis (AR) sufferers. Objective: To compare the gut microbiome composition between adult AR sufferers and controls. Methods: Gut microbial composition in stool
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Elevated Serum Level of CD48 in Patients with Intermittent Allergic Rhinitis. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-23 Olga Branicka,Edyta Jura-Szołtys,Barbara Rogala,Joanna Glück
Background: In the pathogenesis of intermittent allergic rhinitis (IAR), the inflammatory reaction is of importance. CD48, belonging to the CD2 family, participates in mast cell-stimulating cross-talk, facilitates the formation of the mast cell/eosinophil effector unit, and is expressed by eosinophils. Objectives: To assess the serum level of soluble form of CD48 (sCD48) in patients with IAR during
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Effect of the Use of Intranasal Spray of Essential Oils in Patients with Perennial Allergic Rhinitis: A Prospective Study. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-22 Davide Caimmi,Catherine Neukirch,Renaud Louis,Olivier Malard,Gabriel Thabut,Pascal Demoly
Introduction: Among allergic rhinitis (AR) symptoms, nasal obstruction particularly affects the quality of life. Antihistamines and intranasal corticosteroids are the most frequently prescribed symptomatic drugs, but their efficacy is often incomplete. Essential oils (EO) have shown an anti-inflammatory effect and potential in treating patients with AR. The aim of this study was to evaluate the effectiveness
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Does Asthma Increase the Mortality of Patients with COVID-19?: A Systematic Review and Meta-Analysis. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-22 Yuanyuan Wang,Jingjing Chen,Wei Chen,Ling Liu,Mei Dong,Juan Ji,Die Hu,Nianzhi Zhang
The purpose of this systematic review and meta-analysis was to explore the literature and collate data comparing the mortality of coronavirus disease 2019 (COVID-19) patients with and without asthma. The databases PubMed, Scopus, Embase, Google Scholar, and medRxiv.org were searched for studies comparing the clinical outcomes of asthmatic patients with those of nonasthmatic patients diagnosed with
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Descriptive Analysis of Cross-Reactive Anaphylaxis as a Different Clinical Subtype of Nonsteroidal Anti-Inflammatory Drug (NSAID) Hypersensitivity. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-21 Laura Del Mar Vásquez,Diana Lucia Silva,Luis Fernando Ramírez,Manuela Olaya,Carlos Daniel Serrano
Introduction: The European Network of Drug Allergy and the European Academy of Allergy and Clinical Immunology have classified hypersensitivity reactions induced by nonsteroidal anti-inflammatory drugs (NSAIDs) into 5 phenotypes according to the pathophysiology, clinical manifestations, number of drugs involved, and the presence of underlying diseases. This classification does not include anaphylaxis
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Characteristics and Contributing Factors Related to Nonsteroidal Anti-Inflammatory Drugs Hypersensitivity. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-18 Araya Yuenyongviwat,Nisarat Chantaravisarut,Wassamon Phattarapongdilok,Vanlaya Koosakulchai,Wipa Jessadapakorn,Pasuree Sangsupawanich
Introduction: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is reported to be the most common drug hypersensitivity. The aim of this study was to evaluate the characteristics of self-reported NSAID hypersensitivity and identify patients at high risk of NSAID hypersensitivity. Methods: Patients who presented at a single tertiary care hospital between January–December 2017 with reported
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Value of Component Resolved Diagnostics to Aspergillus fumigatus in Patients with Upper Airway Complaints. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-17 Veronika Volgger,Julia Louza,Donata Gellrich,Katharina Eder,Moritz Gröger
Introduction: Sensitization to Aspergillus fumigatus is a risk factor for severe asthma. However, little is known about its presence, appearance, and impact on allergic rhinitis. Herein, we investigated the usefulness of component resolved diagnostics in patients sensitized to Aspergillus fumigatus protein extract. Methods: Seventy-eight patients with suspected allergic rhinitis and elevated IgE levels
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Predisposition to Hyperthyroidism May Be Influenced by Functional TNF-α, IL-1, IL-6, and IL-10 Polymorphisms: A Meta-Analysis. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-17 Hong Ma,Ting Tan,Jie Wu,Juan Chen,Xiaohong Zhang
Background: Predisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), and interleukin-10 (IL-10). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between TNF-α/IL-1/IL-4/IL-6/IL-10
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Risk Factors for Safety of Allergen-Specific Sublingual Immunotherapy in Children with Allergic Rhinitis. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-16 Wenlong Liu,Qingxiang Zeng,Shengbao Yan,Changzhi Sun,Yiquan Tang,Renzhong Luo
A good compliance often attributes to good efficacy and safety of sublingual immunotherapy (SLIT). However, few studies have been conducted on the safety of SLIT treatment in children. We aimed to confirm the pretreatment parameters to predict the safety in children who underwent SLIT. 601 children with allergic rhinitis (AR) treated with SLIT were enrolled in this study. Baseline clinical information
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The Connection between Urinary Equol Levels and the Prevalence of Atopic Dermatitis. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-15 Takahito Chiba,Takuya Nagai,Futoshi Kohda,Takeshi Nakahara,Michihiro Kono
Background: Soy isoflavones and their metabolites such as equol have been associated with a reduced risk of hormone-sensitive tumors and metabolic syndromes. However, individual soy isoflavones and equol levels in atopic dermatitis remain uninvestigated. Objective: The aim of this study is to compare the levels of urinary daidzein, genistein, and equol between atopic dermatitis patients and normal
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Predictive Significance of Charcot-Leyden Crystal Protein in Nasal Secretions in Recurrent Chronic Rhinosinusitis with Nasal Polyps. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-14 Di Wu,Bing Yan,Yang Wang,Luo Zhang,Chengshuo Wang
Introduction: The recurrence occurs frequently among patients with chronic rhinosinusitis with nasal polyps (CRSwNP), and predictors that could be conveniently detected during practice in outpatient service are needed. Objective: We aimed to illustrate that the concentration of Charcot-Leyden crystal (CLC) in nasal secretions can effectively and noninvasively predict polyp recurrence. Methods: 108
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Sensitization to Local Seafood Allergens in Adult Patients with Atopic Dermatitis in Malaysia. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-14 Hock Leng Lee,Min Moon Tang,Mohammed Faizal Bakhtiar,Zailatul Hani Mohamad Yadzir,Asmah Johar
Background: Seafood is an important source of nutrition in Asia. However, it was believed to cause or aggravate atopic dermatitis (AD). Objectives: We aim to determine relevant seafood sensitization among adults with AD and investigate cross-sensitization to aeroallergens. Methods: One hundred thirty-two adults with AD who were subjected to skin prick test (SPT) with 7 common local seafood allergens
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Mite Molecular Profile in the Th2-Polarized Moderate-to-Severe Persistent Asthma Endotype Subjected to High Allergen Exposure. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-14 Ruperto González-Pérez,Paloma Poza-Guedes,Fernando Pineda,Peter Forstenlechner,Miriam Castillo,Elena Mederos-Luís,Martina Aumayr,Víctor Matheu,Cristina Alava-Cruz,Inmaculada Sánchez-Machín
Background: The association among the IgE responses to prevailing groups of house dust mite (HDM) allergens in the concurrent asthma phenotypes has not been determined. Objective: The aim of the present study lays on a component-resolved diagnosis (CRD) model to investigate the mite molecular signature in subjects with type-2 inflammation asthma. Methods: We selected patients showing a clinically relevant
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Inventory of the Recommendations for Patients with Pollen Allergies and Evaluation of Their Scientific Relevance. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-10 Solenne Roubelat,Jean-Pierre Besancenot,Daniel Bley,Michel Thibaudon,Denis Charpin
Pollens are responsible for allergic rhinitis, conjunctivitis, and asthma. The incidence of these diseases, which have adversely impacted the social and professional lives of people who are allergic to pollen, has tripled in the past 25 years. Official institutes, health care institutions, public interest groups, and mainstream news media provide people who are allergic to pollen with advice aimed
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A Comparative Analysis of Allergen Proteins between Plants and Animals Using Several Computational Tools and Chou's PseAAC Concept. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-09 Mandana Behbahani,Parisa Rabiei,Hassan Mohabatkar
Background: A large number of allergens are derived from plant and animal proteins. A major challenge for researchers is to study the possible allergenic properties of proteins. The aim of this study was in silico analysis and comparison of several physiochemical and structural features of plant- and animal-derived allergen proteins, as well as classifying these proteins based on Chou’s pseudo-amino
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Acquired Angioedema due to C1 Inhibitor Deficiency Preceding Splenic Marginal Zone Lymphoma: Further Insights from Clinical Practice. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-09-07 Mariana Paes Leme Ferriani,Orlando Trevisan-Neto,Julia S Costa,Janaina M L Melo,Adriana S Moreno,Marina M Dias,Pedro M M Garibaldi,Gabriel C Pereira,Fernando Chahud,Fabiola Traina,L Karla Arruda
Background: Acquired angioedema due to C1 inhibitor deficiency (AAE-C1-INH) is a very rare disease. In clinical practice, it may be difficult to differentiate AAE-C1-INH from hereditary angioedema due to C1-INH deficiency (HAE-C1-INH). In both conditions, patients are at an increased risk of death from asphyxiation due to upper airway obstruction. The association of AAE-C1-INH with lymphoproliferative
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Immunological and Symptomatic Effects of Oral Intake of Transgenic Rice Containing 7 Linked Major T-Cell Epitopes from Japanese Cedar Pollen Allergens. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-08-27 Tomonori Endo,Daiya Asaka,Tsuguhisa Nakayama,Shota Saito,Hiroki Kodama,Ryoto Mitsuyoshi,Shinya Takaishi,Naoki Sugimoto,Sachiko Omae,Hidenori Takagi,Yuhya Wakasa,Kenjiro Ozawa,Makoto Takano,Fumio Takaiwa,Hiromi Kojima,Saburo Saito
Background: A rice-based peptide vaccine containing 7 linked human predominant T-cell epitopes (7Crp) derived from Japanese cedar (JC) pollen allergens, Cry j 1 and Cry j 2, was developed. Here, we examined the efficacy and safety of this transgenic rice in JC pollinosis patients. Methods: Transgenic rice (5, 20, and 80 g) was administered orally. We measured the T-cell proliferative activity against
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Lysophosphatidic Acid Regulates the Differentiation of Th2 Cells and Its Antagonist Suppresses Allergic Airway Inflammation. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-08-26 Mayo Kondo,Toshifumi Tezuka,Hirohisa Ogawa,Kazuya Koyama,Hiroki Bando,Masahiko Azuma,Yasuhiko Nishioka
Background: Lysophosphatidic acid (LPA), a prototypic member of a large family of lysophospholipids, has been recently shown to play a role in immune responses to respiratory diseases. The involvement of LPA in allergic airway inflammation has been reported, but the mechanism remains unclear. Object: We analyzed the biological activity of LPA in vitro and in vivo and investigated its role in allergic
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Identification of Seasonal Variations of Antibodies against PR-10-Specific Epitopes Can Be Improved Using Peptide-Phage Display. Int. Arch. Allergy Immunol. (IF 2.917) Pub Date : 2020-08-26 Lisbeth Ramírez Caballero,Christoph Kny,Regina Treudler,Jan C Simon,Karolin Kern,Uta Jappe,Michael Szardenings
Background: In pollinosis patients, allergen-specific antibody titers show seasonal variations. Little is known about these variations at the epitope level. Objectives: We aimed at investigating seasonal variations on the level of allergen epitope recognition in patients with Bet v 1-related food allergy using a peptide phage display approach. Methods: Serum samples collected over 1 year from 4 patients