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Effectiveness of Mepolizumab in Patients with Severe Eosinophilic Asthma with/without Nasal Polyposis: A Real-Life Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-30 Francisco Javier Bravo-Gutiérrez,Juan Carlos Miralles-López,José Valverde-Molina,María Loreto Alemany Francés,Rubén Andújar-Espinosa,Manuel Castilla-Martínez,María Jesús Avilés-Inglés,Ana Mora-González,Manuel José Pajarón-Fernández,Sheila Cabrejos-Perotti,José Meseguer-Arce,Isabel Flores Martín,Virginia Pérez-Fernández,
INTRODUCTION Asthma is one of the most common chronic diseases and affects around 334 million people worldwide. The estimated prevalence of severe asthma is 3-10% of the asthmatic population. Mepolizumab has demonstrated efficacy in reducing exacerbations, oral corticosteroid use, and improving quality of life, asthma control, and lung function in patients with severe eosinophilic asthma (SEA). Our
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Comparing Protein and Gene Expression Signature between Nasal Polyps and Nasal Fluids in Chronic Rhinosinusitis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-29 Yilin Hou,Changhui Chen,Zhengqi Li,Tong Lu,Lin Sun,Yi Wei,Jian Li,Weiping Wen
INTRODUCTION Chronic rhinosinusitis with nasal polyps (CRSwNP) is a serious inflammatory condition. Nasal fluids (NFs) present a noninvasive alternative to nasal biopsy for studying CRSwNP pathogenesis. We aimed to compare the protein and mRNA inflammation signature between nasal polyps (NPs) and NFs. METHOD The performance of polyvinyl alcohol (PVA) sponges and NFs absorbable device (NFAD) for collecting
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Comparison of the General Characteristics of Patients with Severe Asthma Who Switched from Omalizumab to Mepolizumab versus Patients Who Responded to Omalizumab Treatment: A Real-Life Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-22 Mehmet Erdem Cakmak,Nida Öztop,Osman Ozan Yeğit
INTRODUCTION Severe asthma is characterized by frequent recurrent airway symptoms and exacerbations, and these affect the quality of life. Biological agents can be used in the treatment of patients with severe asthma if the disease cannot be controlled with standard controller treatment. The aim of this study was to compare the clinical characteristics and laboratory data of patients with severe asthma
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Clinical Features of Quail Egg Ingestion in Patients with Acquired Tolerance to Hen Eggs: A Case Series Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-21 Kosei Yamashita,Yuki Okada,Aiko Honda,Chihiro Kunigami,Mayu Maeda,Toshinori Nakamura,Taro Kamiya,Takanori Imai
INTRODUCTION Patients with hen's egg allergy are often instructed to avoid consuming other avian eggs, such as quail eggs. However, it is unclear whether patients with an acquired tolerance to hen eggs continue to avoid consuming quail eggs. This study aimed to evaluate the clinical features of quail egg ingestion. METHODS This prospective case series included children aged ≥1 year with hen's egg allergy
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FoxP3-Positive Cells and Their Contacts with Mast Cells Are Highly Increased in Basal Cell Carcinoma. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-21 Antti P Kaukinen,Rauno J Harvima,Ilkka T Harvima
INTRODUCTION The cells of the immune system are thought to contribute to the development of skin cancers, such as basal cell carcinoma (BCC). One possible mechanism may be the interaction between mast cells and regulatory T cells (Tregs), resulting in immunosuppression. METHODS Fresh-frozen biopsies from the lesional and nonlesional skin of 16 patients with BCC were processed for the enzymehistochemical
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Gastroesophageal Reflux Disease and Rhinosinusitis: A Bidirectional Mendelian Randomization Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-17 Teng-Yu Chen,Ming-Hui Lv,Ren-Jie Lai,Yu-Qi Hu,Zhong-Kang Ye,Qi-Liang Lv,Bao-Yi Chen,Jun-Tao Wu,Haiyu Hong,Shuo Li
INTRODUCTION Comorbidities, such as gastroesophageal reflux disease (GERD), are common in patients with rhinosinusitis (RS). However, the link between RS and GERD has not been fully understood. This study aimed to investigate the causal relationship between GERD and acute (ARS) or chronic RS (CRS), providing references for the pathogenesis and management of RS. METHODS The data were obtained from the
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Blockade of HMGB1 Reduces Inflammation and Pruritus in Atopic Dermatitis by Inhibiting Skin Fibroblasts Activation. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-14 Lingxuan Zhou,Xiaohui Yuan,Yongyan Hu,Siyu Zhu,Junxiang Li,Chenyu Wang,Miao Jing,Lingling Liu,Zhe Xu,Zuotao Zhao,Jiahui Zhao
INTRODUCTION Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsed eczema and serious pruritus. High-mobility group box 1 protein (HMGB1) is a nuclear-binding protein and serves as an alarmin to promote inflammatory responses. METHODS In this study, we established an AD mouse model by topical use of MC903 on ears and then used a specific HMGB1-binding peptide cIY8
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Biomarkers of Autologous Whole Blood Injection Efficacy in Patients with Chronic Spontaneous Urticaria with Autoreactivity: A Preliminary Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-10 Qiquan Chen,Jincheng Luo,Xianjie Yang,WenChieh Chen,Wenying Liu,Zhiqiang Song
INTRODUCTION Chronic spontaneous urticaria (CSU) with autoreactivity is often resistant to antihistamines. Autologous whole blood injection (AWBI) has shown potential efficacy in the treatment of this disease, but it is controversial. It is necessary to screen patients who are suitable for this therapy in advance. This study aimed to identify biomarkers that predict the efficacy of AWBI treatment in
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Study of Allergy and Sensitization Relationship in Children and Parents in Southern China. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-03 Hui Gan,Zhifeng Huang,Huiqing Zhu,Aoli Li,Tong Chen,Ziyu Yin,Baoqing Sun
INTRODUCTION The incidence of allergic diseases has increased globally, with genetics playing an essential role in these conditions' development. However, there is still a gap in understanding of how parental allergy status affects children's allergies. METHODS An electronic questionnaire was used to assess allergy-related symptoms in kindergarten children and their parents, with a clinical diagnosis
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Efficacy of a Non-Pharmacological Intervention in Seasonal Allergic Rhinitis Symptoms. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-03 Davide Caimmi,Evangéline Clark,Paul Fogel,Nicolas Heddebaut,Michel Aubier,Pascal Demoly
BACKGROUND Patients suffering from allergic rhinitis seek for several therapeutic symptomatic options, including nonconventional treatments, to control their symptoms. OBJECTIVES Through the present proof-of-concept study, we prospectively investigated the potential role of Puressentiel® nasal protection spray (SNPA) in patients suffering from cypress pollen allergic rhinitis. METHODS In 15 adults
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Increasing Prevalence of Sensitization to Cat/Dog Allergens in the COVID-19 Pandemic. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-11-02 Recep Evcen,Fatih Çölkesen,Eray Yıldız,Filiz Sadi Aykan,Mehmet Kılınç,Fatma Arzu Akkuş,Sevket Arslan
INTRODUCTION Cat and dog allergens are common indoor triggers for respiratory allergies such as allergic rhinitis and asthma. This study aims to evaluate the prevalence of cat and dog allergies in adults and analyze changes during the COVID-19 pandemic. METHODS We retrospectively analyzed the medical records of 8,102 patients who visited an allergy clinic and underwent skin prick testing (SPT) from
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Factors Affecting the Ability to Discontinue Oral Corticosteroid Use in Patients with EGPA Treated with Anti-Interleukin-5 Therapy. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-31 Osamu Matsuno
INTRODUCTION Patients with eosinophilic granulomatosis with polyangiitis (EGPA) and some with severe eosinophilic asthma require continuous long-term oral corticosteroid (OCS) treatment for disease control. The anti-interleukin-5 agent, mepolizumab, has recently become available for the treatment of severe eosinophilic asthma and EGPA, with promising results and safety profiles. The proportion of patients
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Prediction of Food Sensitization in Children with Atopic Dermatitis Based on Disease Severity and Epidermal Layer Impairment. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-27 Nguyen Le Huong Tran,Nhung Thi My Ly,Hoang Kim Tu Trinh,Minh Kieu Le,Niem Van Thanh Vo,Duy Le Pham
INTRODUCTION Atopic dermatitis (AD) is characterized by an impaired epidermal barrier, which could be associated with sensitization to food allergens (FAs) and/or inhaled allergens and contribute to the severity of AD. However, no clinical guidance has been established for evaluations of food sensitization (FS) in AD patients. This study investigated how AD severity and epidermal barrier impairment
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Systemic Type 2 Inflammation-Associated Atopic Dermatitis Exacerbates Periodontitis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-20 Yuan Liu,Ziyuan Wang,Wenting Jiang,Yinchao Ma,Haoyan Wang,Yintong Xue,Yan Li,Xiang Gao,Jie Hao,Yuedan Wang,Feng Chen,Ming Chu
INTRODUCTION Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin disease characterized by Th2 cell-mediated type 2 inflammation. Emerging evidence indicated that AD patients exhibit an increased incidence of oral disorders. In the present study, we sought mechanistic insights into how AD affects periodontitis. METHODS Onset of AD was induced by 2,4-dinitrochlorobenzene (DNCB). Furthermore
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Histological Phenotyping in Eosinophilic Esophagitis: Localized Proximal Disease Is Infrequent but Associated with Less Severe Disease and Better Disease Outcome. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-20 Alexis Heil,Tobias Kuehlewindt,Anne Godat,Hans-Uwe Simon,Dagmar Simon,Philipp Schreiner,Catherine Saner,Stephan R Vavricka,Luc Biedermann,Ekaterina Safroneeva,Jean-Benoit Rossel,Andreas Limacher,Alex Straumann,Alain M Schoepfer,Thomas Greuter
INTRODUCTION It is still unknown whether eosinophilic esophagitis (EoE) patients with localized disease are different from those with extended disease. METHODS We evaluated prospectively included patients in the Swiss EoE cohort. Data on all patients with active disease at baseline, no concomitant gastroesophageal reflux disease, no strictures at baseline, and at least one follow-up visit were analyzed
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Decreased Basophil Activation against House Dust Mite after Japanese Cedar Pollen Subcutaneous Immunotherapy: A Retrospective Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-18 Chisato Inuo,Hitoshi Ando,Kenichi Tanaka,Yoichi Nakajima,Ikuya Tsuge,Atsuo Urisu,Yasuto Kondo
BACKGROUND Allergen-specific immunotherapy (AIT), an established treatment for allergic diseases, prevents the development of other allergic manifestations. Although the mechanisms remain unclear, AIT has been shown to reduce basophil activation (BA) against nontarget allergens. OBJECTIVES The aim of this study was to assess immunological changes in Dermatophagoides farinae (Der f) after Japanese cedar
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Atopy Does Not Influence the Clinical Outcome of Acute Urticaria: A Retrospective Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-16 Xianjie Yang,Gaopeng Liang,Huan Wang,Minmin Kong,Zhiqiang Song,Qiquan Chen
BACKGROUND Acute urticaria (AU) may be associated with atopy, but the relationship between atopic status and the clinical features of the disease has not been fully described. OBJECTIVES The aim of the study was to determine the proportion of atopy in AU patients and to see whether atopy is related to the clinical characteristics of AU and whether it has an impact on the outcome of the disease. MATERIALS
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Inhaler Steroid Use Changes Oral and Airway Bacterial and Fungal Microbiome Profile in Asthma Patients. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-10-16 Kıvılcım Oğuzülgen,Ayse Bilge Öztürk,Ayşe Bacceoğlu,Ömür Aydın,Gözde Köycü Buhari,Ebru Damadoğlu,Ferda Öner Erkekol,Özlem Göksel,Gül Karakaya,A Fuat Kalyoncu,Füsun Kalpaklıoğlu,Dilşad Mungan,Haluk Türktaş,Leyla Pur Özyiğit,Çağrı Ergin,Merve Erdoğan,Ayşe Kalkancı
INTRODUCTION The full spectrum of bacterial and fungal species in adult asthma and the effect of inhaled corticosteroid use is not well described. The aim was to collect mouthwash and induced sputum samples from newly diagnosed asthma patients in the pretreatment period and in chronic asthma patients while undergoing regular maintenance inhaled corticosteroid therapy, in order to demonstrate the bacterial
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The Relationship between Allergic Disease and Sexual Dysfunction: A Scoping Review. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-20 Ting-Yi Chiang,Hsiang-Ying Lee,Wei-Chen Chien,Hsiao-Chun Su,Yung-Chun Su,Chung-Wei Lin
INTRODUCTION Sexual dysfunction (SD) and allergic disease are common health concerns worldwide and bear a potential relationship. This scoping review is conducted to analyze the currently available data regarding the associations between these two health issues. METHODS A comprehensive literature search was performed in the databases of PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled
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Drug Allergy in Children: Adverse Reactions after Skin Testing. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-20 Cagla Karavaizoglu,Ayse Suleyman,Roza Yavuz Alıc,Kazım Okan Dolu,Esra Yucel,Zeynep Hızlı Demirkale,Sevgi Sipahi Cimen,Cevdet Ozdemir,Zeynep Ulker Tamay
INTRODUCTION Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the
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miR-410 Regulates Helper T Cell Differentiation in Ovalbumin-Induced Asthma through the PI3K-AKT-VEGF Signaling Pathway. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-19 Nianting Tong,Dongyun Liu,Ling Lu,Rongjun Lin,Rong Jin
INTRODUCTION Asthma has been attributed to Th1/Th2 imbalance and inappropriate Th2 responses to environmental allergens. MicroRNAs (miRNAs), 21 to 23 RNA molecules, are first found in mammals and have been implicated in various biological activities. Our previous study found that miR-410 effectively ameliorates airway inflammation in the ovalbumin (OVA)-induced asthma murine model. However, the role
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Safety of Oral Food Challenge for Individuals with Low Egg White and Ovomucoid-Specific IgE Antibodies. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-19 Mika Ogata,Takanobu Yoshida,Jun Kido,Natsuko Nishi,Sachiko Shimomura,Nami Hirai,Masaaki Yanai,Tomoyuki Mizukami,Kimitoshi Nakamura
INTRODUCTION During an oral food challenge (OFC), there is a risk of adverse reactions, including anaphylaxis. Therefore, the physician should carefully conduct the OFC. This study aimed to evaluate the OFC results in individuals with low levels of egg white (EW)- and ovomucoid (OVM)-specific immunoglobulin E (sIgE) and the safety of a hen's egg (HE) OFC in these individuals. METHODS A total of 2,058
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A Decade of Pathogenesis Advances in Non-Type 2 Inflammatory Endotypes in Chronic Rhinosinusitis: 2012-2022. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-18 Na Cui,Xuewei Zhu,Chen Zhao,Cuida Meng,Jichao Sha,Dongdong Zhu
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by localized inflammation of the upper airways. CRS includes two main phenotypes, namely, CRS with nasal polyps and CRS without nasal polyps. The phenotype-based classification method cannot reflect the pathological mechanism. The endotype-based classification method has been paid more and more attention by researchers. It is mainly
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Regulation of T Helper Cell Type 2 Immune Response by Controlling Beta-2 Adrenergic Receptor in Dendritic Cells of Patients with Allergic Rhinitis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-15 Ji Woo Yeon,Byoungjae Kim,Junhyoung Byun,Semyoung Jung,Jaehyung Park,Munsoo Han,Seung-Kuk Baek,Tae Hoon Kim
INTRODUCTION Allergic diseases are mediated by T helper cell type 2 (Th2) cells, which are differentiated by dendritic cells (DCs). Recently, it was reported that cAMP concentration in DCs is important for inducing allergic responses. However, the regulatory function of cAMP in DCs in Th2 immune responses is unclear. It was hypothesized that the regulation of G protein-coupled receptors (GPCRs) to
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Cold Atmospheric Plasma: A Promising and Safe Therapeutic Strategy for Atopic Dermatitis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-13 Fan Bai,Yutong Ran,Siyue Zhai,Yumin Xia
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Microbial infection, immune system dysfunction, and skin barrier defunctionalization have been regarded as the central events in AD pathogenesis. Cold atmospheric plasma (CAP) is an unbound system composed of many free electrons, ions, and neutral particles, with macroscopic time and spatial scales. Based on dielectric barrier discharge
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Low-Density Lipoprotein Cholesterol Is Associated with Atopic Dermatitis in Korean Adolescents. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-08 Min Kyeong Seong,Meeyong Shin
INTRODUCTION Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Several studies have investigated the relationship between obesity and AD prevalence, but the results have been conflicting. This study investigated the association between obesity and AD in Korean adolescents. METHODS We used nationally representative data regarding 1,617 Korean adolescents aged 12-18
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Airway Microbiome Composition and Co-Occurrence Network Are Associated with Inflammatory Phenotypes of Asthma. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-08 Yi Li,Congying Zou,Jieying Li,Wen Wang,Feiran Wang,Yue Guo
INTRODUCTION The composition and co-occurrence network of the airway microbiome might influence the asthma inflammatory phenotype. Airway microbiota change with asthma phenotypes, and the structure of the bacterial community in the airway might differ between different asthma inflammatory phenotypes and may also influence therapy results. Identifying airway microbiota can help to investigate the role
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How Does Pregnancy and Type of Delivery Affect the Clinical Course of Hereditary Angioedema? Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-06 Deniz Eyice Karabacak,Ali Can,Semra Demir,Osman Ozan Yegit,Bahauddin Colakoglu,Suna Buyukozturk,Aslı Akkor Gelincik
INTRODUCTION Knowledge on the clinical course of hereditary angioedema (HAE) during pregnancy, delivery, and breastfeeding is very limited. In this study, we aimed to evaluate the course of HAE during these periods. METHODS The HAE attacks C1-INH prophylaxis before and during pregnancy and during breastfeeding, and the delivery types were retrospectively determined. The severity of attacks was assessed
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Prevalence of Trimethoprim-Sulfamethoxazole Adverse Reaction Mislabelling in Australia. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-06 Lydia Lam,Melinda Jiang,Stephen Bacchi,Joshua Kovoor,Joshua M Inglis,Sepehr Shakib,Carlo Yuson,William Smith
INTRODUCTION Trimethoprim-sulfamethoxazole (TMP-SMX) is an important antibiotic, with the most compelling indications for Pneumocystis jirovecii pneumonia prophylaxis and methicillin-resistant Staphylococcus aureus treatment. Previous adverse reactions (AR) to TMP-SMX may limit the usability of TMP-SMX. Electronic medical record (EMR) of AR for other antibiotics has previously been shown to be inaccurate;
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Allergen Differences and Correlation Analysis in Siblings Diagnosed with Respiratory Allergic Diseases. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-05 Liping Liu,Weihua Wang,Yuemei Sun,Guangrun Li
INTRODUCTION Many parents of children with allergies are worried whether their subsequent children will have allergic reactions to the same allergens. Much of the current research on sibling allergens has been focused on twins; however, in real life, very few children are twins. Our study provides an opportunity to initially explore the sensitivity to allergens in siblings diagnosed with respiratory
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Risk Factors for Acute Rhinosinusitis in Childhood Asthma. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-09-05 Hanrui Wang,Jianwei Wang,Zheying Song,Jing Guo,Yujuan Yang,Zi Liu,Yuemei Sun,Liping Liu,Yu Zhang,Xicheng Song
INTRODUCTION Specific pathogen infections associated with acute rhinosinusitis (ARS) in infants are risk factors for allergic asthma in adolescents. However, the risk factors for ARS onset remain largely unknown in asthmatic children. In this study, we aim to investigate the risk factors for ARS in childhood asthma. METHODS This study retrospectively compared and analyzed the clinical characteristics
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Development of an Oral Immunotherapy-Related Parental Burden Scale. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-30 Akihiro Maeta,Yuri Takaoka,Masaaki Hamada,Atsuko Nakano,Shinichi Sumimoto,Kaori Anzai,Yukiko Tanaka,Satoru Morikawa,Makoto Kameda,Kyoko Takahashi
INTRODUCTION Oral immunotherapy (OIT) imposes a burden on parents and their children with food allergies (FAs). We already developed a questionnaire for OIT-related Parental Burden (OIT-PB) scale. However, the previous questionnaire had some problems. This study modified OIT-PB and verified its reliability and validity. METHODS A 20-item draft covering the physical and mental burdens caused by OIT
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Higher Prevalence and Severity of Eosinophilic Otitis Media in Patients with Asthma-COPD Overlap Compared with Asthma Alone. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-24 Emiri Sato,Yukako Seo,Etsuko Tagaya,Osamitsu Yagi,Yukie Yamamura,Manabu Nonaka
INTRODUCTION Eosinophilic otitis media (EOM) is well-known to frequently co-exist with adult-onset asthma. Both diseases are similar type 2 inflammation and are considered to have a "one airway, one disease" relationship. Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO), characterized by airway obstruction caused by airway wall thickening (AWT), is a severe condition with a higher
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A Survey of Airborne Fungi and Their Sensitization Profile in Wuhan, China. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-23 Lin Yang,Wenjing Li,Shanshan Qi,Qing Jiang,Nan Huang,Yaqi Yang,Dongxia Ma,Wei Zhang,Hao Chen,Rongfei Zhu
INTRODUCTION Airborne fungi induce allergic symptoms in 3-10% of the population worldwide. To better prevent and manage fungi-related allergic diseases, it is essential to identify the genus and the distribution profile of airborne fungi. METHODS With this purpose in mind, we carried out a 12-month volumetric sampling study to monitor the airborne fungi and retrospectively analyzed the sensitization
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Maternal Dietary Vitamin D Intake during Pregnancy Is Associated with Allergic Disease Symptoms in Children at 3 Years Old: The Japan Environment and Children's Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-22 Muneyuki Shimizu,Taisuke Kato,Yuichi Adachi,Takuya Wada,Shokei Murakami,Yasunori Ito,Toshiko Itazawa,Yoko S Adachi,Akiko Tsuchida,Kenta Matsumura,Kei Hamazaki,Hidekuni Inadera,
INTRODUCTION Vitamin D plays an important role in the immune system, and postnatal vitamin D insufficiency is one of the risk factors for the development of allergic disease. However, the effects of women's vitamin D intake during pregnancy on the prevalence of allergic disease in their children remain controversial. METHODS From the Japan Environment and Children's Study, an ongoing nationwide birth
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Higher House Dust Mite-Specific IgE Levels among Chronic Spontaneous Urticaria Patients May Implicate Higher Basophil Reactivity. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-21 Gaopeng Liang,Jie Zhou,Lanlan Jiang,Wenwen Wang,Qijun Wu,Cuie Gao,Wenying Liu,Shifei Li,Shujing Feng,Zhiqiang Song
INTRODUCTION Allergen-specific IgE (sIgE) sensitization exists in a considerable fraction of chronic spontaneous urticaria (CSU) patients. Basophils have been implicated in the pathogenesis of CSU. This paper aimed to explore the relationship between allergic sensitization and basophil reactivity in CSU and the possible underlying mechanism. METHODS Basophil-enriched leukocytes were isolated from the
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Risk Factors for Abnormal Small Airway Function Indicators in Nasal Polyp Patients with and without Asthma. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-18 Jing Guo,Jianwei Wang,Xinjun Xu,Yujuan Yang,Pengyi Yu,Zhen Liu,Jiayu Cao,Qintai Yang,Yu Zhang,Xicheng Song
INTRODUCTION Small airway dysfunction (SAD) is associated with type 2 inflammation in patients who have non-asthmatic chronic rhinosinusitis with nasal polyps (CRSwNPs); however, the risk factors for abnormal small airway function indicators in CRSwNP patients with and without asthma remain unclear. METHODS We retrospectively analyzed 41 asthmatic and 109 non-asthmatic CRSwNP patients. Clinical characteristics
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Drug Allergy Alert System in a Spanish University Hospital: Description and Dynamics of Use. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-18 Ana Rosado-Ingelmo,Ana Belen Pastor Magro,Maria Angeles Pizarro-Jaraiz,Sira Sanz-Marquez,Genma M Silva Riádigos,Yesenia Peña Acevedo,Anna Tejedor-Alberti,Miguel Angel Tejedor-Alonso
INTRODUCTION The drug allergy alert system reduces the frequency of adverse drug events, although it is subjected to collateral effects, since 80-90% of alerts are not real, and a large percentage of alerts are overridden (46.2-96.2%). We reviewed how the alert system is used at University Hospital Fundación Alcorcon (HUFA). METHODS Data were obtained from the drug allergy alert and the alert overriding
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Interaction between Serum Cotinine and Magnesium Intake with Childhood Asthma: A Cross-Sectional Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-18 Jianwei Cao,Meiling Liu,Zhongquan Wang,Ying Huang,Kaijun Zheng
INTRODUCTION Serum cotinine and magnesium intake are often associated with childhood asthma. This study evaluated the interaction between serum cotinine and magnesium intake and childhood asthma. METHODS This cross-sectional study included 14,159 subjects from the National Health and Nutrition Examination Survey 2005-2018. Serum cotinine levels were classified according to the lower quartile: ≤0.2089
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Assessment of Subclinical Atherosclerosis in Children with Atopic Dermatitis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-16 Yasemin Mocan Çağlar,Hayrunnisa Bekis Bozkurt,Öykü İsal Tosun,Özlem Cavkaytar,Mustafa Arga
INTRODUCTION Data from studies conducted to date have evaluated clinical atherosclerotic conditions in adult patients with atopic dermatitis (AD). Subclinical atherosclerotic changes that are a precursor of atherosclerotic conditions may begin in childhood. The aim of this study was to investigate the presence of subclinical atherosclerosis in pediatric patients with AD and to determine the associated
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TCN1 Expression Is Increased in Asthma. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-16 Changyi Xu,Lijuan Du,Yubiao Guo,Yuxia Liang
INTRODUCTION Asthma is a chronic disease that affects populations worldwide. The purpose of this study was to investigate the expression of TCN1 in sputum and its correlation with inflammation and lung function in asthma. METHODS We recruited 141 subjects, detected TCN1 mRNA level by quantitative reverse transcription polymerase chain reaction, detected TCN1 protein expression by Western blot, detected
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Sodium Chloride versus Lactose as a Carrier for House Dust Mite Allergen in Allergen Chamber Studies: A Clinical Study to Assess Noninferiority. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-16 Nadja Struß,Susanne Dieter,Katharina Schwarz,Philipp Badorrek,Jens M Hohlfeld
INTRODUCTION In the Fraunhofer allergen challenge chamber (ACC), a standardized, universal, good manufacturing practice-conforming technology using a spray dried solution of lactose (L) and allergen extract has been established. In this study, we investigated the noninferiority of hypertonic sodium chloride (S) versus L as a carrier for house dust mite (HDM) allergen to simplify manufacturing, reduce
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Allergic to ChatGPT? Introducing a Desensitization Protocol to Embrace Artificial Intelligence. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-09 Pamir Cerci
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Anti-TPO IgG/Total IgE Ratio: Biomarker for Omalizumab Response Prediction in Chronic Spontaneous Urticaria. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-09 Rita Brás,Leonor Esteves Caldeira,Ana Bernardino,Célia Costa
BACKGROUND According to recently published data, low total IgE, elevated IgG-anti-TPO, and a high IgG-anti-TPO/total IgE ratio are good biomarkers for subtype IIb autoimmune chronic spontaneous urticaria (CSU), which is frequently refractory to antihistamines and omalizumab. OBJECTIVES The aim of the study was to evaluate IgG-anti-TPO/total IgE ratio's utility in omalizumab response prediction. METHODS
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C-C Motif Chemokine Receptor 3-Mediated Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase Signaling: Promising Targets for Human Airway Epithelial Mucin 5AC Induction by Eotaxin-2 and Eotaxin-3. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-08 Sooyeon Jo,Hyung Gyun Na,Yoon Seok Choi,Chang Hoon Bae,Si-Youn Song,Yong-Dae Kim
INTRODUCTION Eotaxin-2 and -3 of the C-C chemokine subfamily function as potent chemoattractant factors for eosinophil recruitment and various immune responses in allergic and inflammatory airway diseases. Mucin 5AC (MUC5AC), a major gel-forming secretory mucin, is overexpressed in airway inflammation. However, the association between mucin secretion and eotaxin-2/3 expression in the upper and lower
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Allergic Fungal Rhinosinusitis in Europe: Literature Review and Own Experience. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-08-03 Magdalena Kokoszka,Grażyna Stryjewska-Makuch,Ada Kantczak,Dorota Górny,Joanna Glück
Allergic fungal rhinosinusitis (AFRS) is primary, Th2-mediated, chronic rhinosinusitis, which is diagnosed when the criteria defined by Bent and Khun are met. The disease is most common in countries located in the subtropical and tropical regions characterized by high temperatures and high levels of humidity, which favour the wider occurrence of fungi in the environment. The presence of specific IgE
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A Comprehensive Assessment of Long-Term Complications in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-26 Sukru Cekic,Yakup Canitez,Hale Yuksel,Gamze Ucan Gunduz,Zuhal Karali,Ozgur Yalcinbayir,Pınar Vural,Nihat Sapan
INTRODUCTION Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare severe hypersensitivity reactions that lead to epithelial sloughing. Studies investigating the chronic multisystem effects of these syndromes and assessing patients in terms of quality of life (QOL), depression, and anxiety in the pediatric population are limited. In this study, we aimed
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Allergic Diseases as a Clinical Phenotype Marker in Patients with Common Variable Immunodeficiency. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-20 Eray Yıldız,Fatih Çölkesen,Sevket Arslan,Recep Evcen,Filiz Sadi Aykan,Mehmet Kılınç
INTRODUCTION Patients with common variable immunodeficiency (CVID) have been shown to be more predisposed to develop allergic diseases because of mucosal immune defects and immune dysregulation. The aim of this study was to determine the prevalence, and clinical and laboratory characteristics of various allergic diseases in patients with CVID. METHODS The study included patients aged ≥18 years who
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Alpha/Beta Gliadin MM1 Is a Novel Antigen for Wheat-Dependent Exercise-Induced Anaphylaxis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-20 Yuji Aoki,Akiko Yagami,Tomomi Sakai,Satoshi Ohno,Nayu Sato,Masashi Nakamura,Kyoko Futamura,Kayoko Suzuki,Takahiko Horiguchi,Seiichi Nakata,Kayoko Matsunaga
INTRODUCTION Screening for ω-5 gliadin specific IgE antibody (sIgE) has high diagnostic utility in cases of suspected wheat-dependent exercise-induced anaphylaxis (WDEIA); however, negative cases may require confirmatory tests, such as the oral challenge test. Thus, newly identified allergens that can be used for the serological diagnosis of WDEIA are needed. This study aimed to identify additional
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Potential Cost Savings by Switching from Subcutaneous to Intralymphatic Insect Venom Immunotherapy. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-19 Alexandra Chabot,Claudia Lang,Thomas M Kündig,Peter Schmid-Grendelmeier,Pål Johansen
INTRODUCTION IgE-mediated bee venom allergy can be treated with allergen-specific immunotherapy (AIT). Subcutaneous immunotherapy (SCIT) is time and cost intensive due to the repeated consultations, but the costs are justified by the high risk of potentially life-threatening allergic reactions, including anaphylaxis. However, intralymphatic immunotherapy (ILIT) offers potential to reduce treatment
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Hypersensitivity Reaction and Rapid Drug Desensitization with Chemotherapeutics: A Tertiary Reference Center Experiences. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-13 İsmet Bulut,Zeynep Yegin Katran
INTRODUCTION Chemotherapy drugs have been in our lives for a long time, and all agents have the potential to develop hypersensitivity. Rapid drug desensitization is an option when hypersensitivity develops. The aim of this study was to examine the characteristics, diagnostic processes, and treatment results of patients with chemotherapeutic agent hypersensitivity who applied to our tertiary reference
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Sensitisation to House Dust Mite Component Der p 23 Is Associated with Severe Symptoms and Asthma in Allergic Rhinitis Patients. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-12 Yunbo Gao,Jingyun Li,Xu Xu,Chengshuo Wang,Yuan Zhang,Luo Zhang
INTRODUCTION House dust mite (HDM) is an important source of airborne allergens in China as it contains several allergenic components that can cause allergic rhinitis (AR) and other allergic diseases. This study aimed to determine the clinical characteristics and disease severity in AR patients sensitised to different allergenic HDM components. METHODS This was a retrospective study, which examined
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A Pilot Study to Identify Grass Species That Mediate Pollen Allergy in Thailand. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-07-04 Pakawat Jarupund,Prayoon Jantrakulroj,Chalermpol Suwanphakdee,Chomdao Sinthuvanich
INTRODUCTION Some grass species that are either common or widely spread in Thailand have not been used for pollen allergy diagnosis. In order to improve diagnostic accuracy, the aim of this pilot study was to identify the grass species responsible for pollen allergy in Thailand. METHODS The skin sensitization of pollen extracts from six different grass species, including rice (Oryza sativa), corn (Zea
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A Dietary Pattern for High Estimated Total Fat Amount Is Associated with Enhanced Allergy Sensitization and Atopic Diseases among Singapore/Malaysia Young Chinese Adults. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-30 Jun Jie Lim,Kavita Reginald,Yee-How Say,Mei Hui Liu,Fook Tim Chew
INTRODUCTION Frequent dietary patterns for fast food diets are suggested to be a risk factor for atopic disease development. Excessive dietary fats in fast foods are postulated to promote low-grade chronic inflammation. However, no studies in Asia have yet to characterize the dietary pattern for high-fat foods with atopic diseases. Thus, this study aims to assess the association between dietary fats
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CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-21 Jing Zheng,Xi Chen,Jia-Bin Zhan,Chang-Wu Li,Xin Wei,Hong-Yan Jiang
INTRODUCTION Circular RNAs (circRNAs) are essential in the progression of allergic rhinitis (AR). The purpose of this research was to examine the role of circRNA ADP-ribosylation factor 3 (circARF3) in the pathogenesis of AR. METHODS To generate an animal model of AR, mice were treated with house dust mite (HDM), and mice nasal epithelial cells (NEpCs) were treated with IL-4/IL-13 to imitate the inflammatory
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The ERBB2 Exonic Variant Pro1170Ala Modulates Mitogen-Activated Protein Kinase Signaling Cascades and Associates with Allergic Asthma. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-19 Yang Yie Sio,Wei Liang Gan,Wing Shan Ng,Sri Anusha Matta,Yee-How Say,Keng Foo Teh,Yi Ru Wong,Smyrna Moti Rawanan Shah,Kavita Reginald,Fook Tim Chew
INTRODUCTION Previous studies have indicated the ERBB2 genetic variants in the 17q12 locus might be associated with asthma; however, the functional effects of these variants on asthma risk remain inconclusive. This study aimed to characterize the functional roles of asthma-associated ERBB2 single nucleotide polymorphisms (SNPs) in asthma pathogenesis by performing genetic association and functional
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Endotyping Difficult-to-Treat Chronic Rhinosinusitis with Nasal Polyps by Structured Histopathology. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-16 Yueming Cui,Kanghua Wang,Jianbo Shi,Yueqi Sun
INTRODUCTION This study aimed to identify the histopathologic characteristics associated with difficult-to-treat chronic rhinosinusitis with nasal polyps (CRSwNPs), enabling physicians to predict the risk of poor outcome after endoscopic sinus surgery (ESS). METHODS A prospective cohort study performed at the First Affiliated Hospital of Sun Yat-sen University between January 2015 and December 2018
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Glycopeptide Antibiotics Impair Neutrophil Effector Functions. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-15 Paul Ettel,Al Nasar Ahmed Sehgal,Nicole Harrison,Winfried F Pickl,Katharina Grabmeier-Pfistershammer
INTRODUCTION Neutrophilic granulocytes represent the first line of defense against microorganisms. Granulocytes phagocytose microorganisms and specifically synthesize oxygen radicals against them, which eventually kills the invaders. METHODS Neutrophilic granulocytes were isolated from peripheral blood of healthy volunteer donors. Putative interference of new-generation antibiotics with neutrophil
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Delabeling of Penicillin Allergy: Room for Improvement. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-15 Sara Fransson,Christina Monnerup Damving,Jonas Bredtoft Boel,Magnus Arpi,Ida Gjørup Skinhøj,Jens Otto Jarløv,Holger F Mosbech,Lars K Poulsen,Lene H Garvey
BACKGROUND Penicillin allergy labels have been shown to be associated with suboptimal treatment, negative health outcomes, and increased antibiotic resistance. Many inpatients claim to have penicillin allergy, but studies show that allergy can be disproved and the label removed in up to 90% of cases. OBJECTIVES The purpose of the study was to investigate the proportion of patients with a penicillin
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Analysis of Multimorbidity of Moderate to Severe Allergic Rhinitis in Children: A Real-World Study. Int. Arch. Allergy Immunol. (IF 2.8) Pub Date : 2023-06-08 Zheng Gu,Ping Wei,Wei Kou,Xin-Ye Tang,Hong-Bing Yao,En-Mei Liu
INTRODUCTION Allergic rhinitis (AR) in children is associated with various comorbidities, posing challenges for treatment and management. There have been few investigations of these multimorbidities in Chinese children with AR. Here, we investigated the prevalence of multimorbidities in children with moderate to severe AR and analyzed the influencing factors using real-world data. METHODS In total