-
Skeletons in the Cupboard of Dysfunctional Neutrophils Revealed J. Innate Immun. (IF 4.932) Pub Date : 2021-01-21 Heiko Herwald; Arne Egesten
J Innate Immun
-
C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37 J. Innate Immun. (IF 4.932) Pub Date : 2021-01-14 Susanne Mommert; Lisa Doenni; Phillip Szudybill; Christoph Zoeller; Frerk Hinnerk Beyer; Thomas Werfel
To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with different TLR ligands. Protein staining followed by flow cytometry revealed highly constitutive intracellular expression levels of the C3aR in NHEKs
-
The Role of Cell Metabolism in Innate Immune Memory J. Innate Immun. (IF 4.932) Pub Date : 2020-12-30 Anaisa Valido Ferreira; Jorge Domiguéz-Andrés; Mihai Gheorghe Netea
Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections. This phenomenon, coined trained immunity or innate immune memory, is based on the epigenetic reprogramming and the rewiring of intracellular metabolic
-
Erratum J. Innate Immun. (IF 4.932) Pub Date : 2020-12-28 H. Herwald; A. Egesten; Arne Egesten; Heiko Herwald; Dominik Hartl; Tsukasa Seya; Oliver Soehnlein; Frank R. DeLeo; Michal Holub; Victor Nizet; Argyrio N. Theofilopoulos; Erica Crouch; Siamon Gordon; Philip. M. Murphy; Uli Theopold; Veronique Witko Sarsat; Michael A. Zasloff; Bruce Beutler; Björn Dahlbäck; Matthias Hornef; Tsuneyasu Kaisho; Eva Medina; James E. Pease; Grant McFadden; James A. Russell;
J Innate Immun
-
Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis J. Innate Immun. (IF 4.932) Pub Date : 2020-12-17 Yanliang Yang; Lingli Xie; Yanjun Zhong; Xiaoli Zhong; Ran Meng; Qianqian Xue; Fang Liang; Kai Zhao; Yiting Tang
Double-stranded RNA dependent kinase R (PKR) is originally identified as an intracellular sensor of viral infection, but its role in bacterial infection remains largely unknown. Here we report that PKR was an important regulator of antibacterial immunity in sepsis. Genetic deletion of PKR or pharmacological inhibition of its kinase activity markedly increased bacterial loads, organ injury, and mortality
-
Helminth Antigen Exposure Enhances Early Immune Control of Mycobacterium tuberculosis in Monocytes and Macrophages J. Innate Immun. (IF 4.932) Pub Date : 2020-12-17 Shambhuprasad Kotresh Togarsimalimath; Giggil Pushpamithran; Thomas Schön; Olle Stendahl; Robert Blomgran
Helminth and Mycobacterium tuberculosis (Mtb) coinfection is common and suggested to influence the risk of developing active tuberculosis (TB). It is known that helminths in contrast to TB induce a strong Th2 response in the host. However, the direct impact of helminth antigen exposure on host immunity against TB is largely unknown. Our aim was to explore the effects of helminth antigen exposure on
-
Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma J. Innate Immun. (IF 4.932) Pub Date : 2020-12-03 Tianyue Wang; Qianlan Zhou; Yunxiao Shang
Children exposed to common aeroallergens may develop asthma that progresses into adulthood. Inflammation regulated by T helper 2 (Th2) cells, a specific subpopulation of CD4+ T lymphocytes, is involved in asthmatic injury. Herein, our microarray data indicated that microRNA-451a-5p (miRNA-451a) expression decreased by 4.6-fold and ETS proto-oncogene 1 (ETS1) increased by 2.2-fold in the peripheral
-
Acknowledgement to the Reviewers J. Innate Immun. (IF 4.932) Pub Date : 2020-11-30
J Innate Immun 2020;12:490–492
-
The Route of Infection Influences the Contribution of Key Immunity Genes to Antibacterial Defense in Anopheles gambiae J. Innate Immun. (IF 4.932) Pub Date : 2020-11-18 Amira San Dekmak; Xiaowei Yang; Heinrich Zu Dohna; Nicolas Buchon; Mike A. Osta
Insect systemic immune responses to bacterial infections have been mainly studied using microinjections, whereby the microbe is directly injected into the hemocoel. While this methodology has been instrumental in defining immune signaling pathways and enzymatic cascades in the hemolymph, it remains unclear whether and to what extent the contribution of systemic immune defenses to host microbial resistance
-
RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection J. Innate Immun. (IF 4.932) Pub Date : 2020-11-05 Nardhy Gomez-Lopez; Roberto Romero; Aneesha Varrey; Yaozhu Leng; Derek Miller; Bogdan Done; Yi Xu; Gaurav Bhatti; Kenichiro Motomura; Meyer Gershater; Roger Pique-Regi; Adi L. Tarca
Intra-amniotic infection, the invasion of microbes into the amniotic cavity resulting in inflammation, is a clinical condition that can lead to adverse pregnancy outcomes for the mother and fetus as well as severe long-term neonatal morbidities. Despite much research focused on the consequences of intra-amniotic infection, there remains little knowledge about the innate immune cells that respond to
-
Who is WHO? J. Innate Immun. (IF 4.932) Pub Date : 2020-11-05 Heiko Herwald; Arne Egesten
J Innate Immun 2020;12:1–2
-
PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury J. Innate Immun. (IF 4.932) Pub Date : 2020-10-12 Yunjuan Nie; Teja Srinivas Nirujogi; Ravi Ranjan; Brenda F. Reader; Sangwoon Chung; Megan N. Ballinger; Joshua A. Englert; John W. Christman; Manjula Karpurapu
Pulmonary macrophages play a critical role in the recognition of pathogens, initiation of host defense via inflammation, clearance of pathogens from the airways, and resolution of inflammation. Recently, we have shown a pivotal role for the nuclear factor of activated T-cell cytoplasmic member 3 (NFATc3) transcription factor in modulating pulmonary macrophage function in LPS-induced acute lung injury
-
Plasma Levels of Hepcidin and Reticulocyte Haemoglobin during Septic Shock. J. Innate Immun. (IF 4.932) Pub Date : 2020-09-18 Jon Olinder,Daniel Ehinger,Erik Liljenborg,Heiko Herwald,Cecilia Rydén
Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring rapid
-
In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation. J. Innate Immun. (IF 4.932) Pub Date : 2020-09-16 Yoojin Lee,Heewook Shin,Jongsun Kim
Natural killer (NK) cells are innate immune lymphocytes that play an important role in anti-viral and anti-tumour immune responses. Several cancer immunotherapy approaches targeting NK cells are currently in clinical or preclinical development. Here, we aimed to find food nutrients that activate NK cells and determine their usefulness as candidates for anti-cancer and anti-metastatic drugs. Resveratrol
-
Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis. J. Innate Immun. (IF 4.932) Pub Date : 2020-09-14 Jiraphorn Issara-Amphorn,Wiwat Chancharoenthana,Peerapat Visitchanakun,Asada Leelahavanichkul
The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb−/−) mice with sepsis. As a proof of concept study, we activated macrophages with BG combined with
-
Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation. J. Innate Immun. (IF 4.932) Pub Date : 2020-09-09 Tim Bleul,Xinyu Zhuang,Antonia Hildebrand,Clemens Lange,Daniel Böhringer,Günther Schlunck,Thomas Reinhard,Thabo Lapp
Purpose: To investigate immunological differences and the role of CD38+/F4/80 + M1 macrophages in C57BL/6J- and BALB/c-recipient mouse corneal transplantation models. Methods: Allogeneic transplantation was performed crosswise in BALB/c mice and C57BL/6J mice; syngeneic transplantation was performed in both strains. Anterior chamber depth (ACD) was measured before and central corneal thickness (CCT)
-
When Actin is Not Actin' Like It Should: A New Category of Distinct Primary Immunodeficiency Disorders. J. Innate Immun. (IF 4.932) Pub Date : 2020-08-26 Evelien G G Sprenkeler,Steven D S Webbers,Taco W Kuijpers
An increasing number of primary immunodeficiencies (PIDs) have been identified over the last decade, which are caused by deleterious mutations in genes encoding for proteins involved in actin cytoskeleton regulation. These mutations primarily affect hematopoietic cells and lead to defective function of immune cells, such as impaired motility, signaling, proliferative capacity, and defective antimicrobial
-
Increased CD11b and Decreased CD62L in Blood and Airway Neutrophils from Long-Term Smokers with and without COPD. J. Innate Immun. (IF 4.932) Pub Date : 2020-08-21 Marit Stockfelt,Karin Christenson,Anders Andersson,Lena Björkman,Médea Padra,Bettina Brundin,Koustav Ganguly,Helga Asgeirsdottir,Sara Lindén,Ingemar Qvarfordt,Johan Bylund,Anders Lindén
There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as neutrophils extravasate, and whether surface density of CD11b and CD62L differs between
-
A Leak in the Dike. J. Innate Immun. (IF 4.932) Pub Date : 2020-08-20 Arne Egesten,Heiko Herwald
J Innate Immun
-
The Road Not Taken: Commensal or Virulent Pathogen. J. Innate Immun. (IF 4.932) Pub Date : 2020-06-25 H. Herwald; A. Egesten; Arne Egesten; Heiko Herwald; Dominik Hartl; Tsukasa Seya; Oliver Soehnlein; Frank R. DeLeo; Michal Holub; Victor Nizet; Argyrio N. Theofilopoulos; Erica Crouch; Siamon Gordon; Philip. M. Murphy; Uli Theopold; Veronique Witko Sarsat; Michael A. Zasloff; Bruce Beutler; Björn Dahlbäck; Matthias Hornef; Tsuneyasu Kaisho; Eva Medina; James E. Pease; Grant McFadden; James A. Russell;
J Innate Immun
-
The Role of Type I IFNs in Influenza: Antiviral Superheroes or Immunopathogenic Villains? J. Innate Immun. (IF 4.932) Pub Date : 2020-06-19 Wenxin Wu,Jordan P Metcalf
The important role of interferons (IFNs) in antiviral innate immune defense is well established. Although recombinant IFN-α was approved for cancer and chronic viral infection treatment by regulatory agencies in many countries starting in 1986, no IFNs are approved for treatment of influenza A virus (IAV) infection. This is partially due to the complex effects of IFNs in acute influenza infection.
-
Activation, Deficiency, and Reduced IFN-γ Production of Mucosal-Associated Invariant T Cells in Patients with Inflammatory Bowel Disease. J. Innate Immun. (IF 4.932) Pub Date : 2020-06-12 Jae Kyun Ju,Young-Nan Cho,Ki-Jeong Park,Han Deok Kwak,Hye-Mi Jin,Seon-Young Park,Hyun Soo Kim,Seung-Jung Kee,Yong-Wook Park
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can activate either in response to T-cell receptor (TCR) engagement or through activating cytokines and play an important role in autoimmune disorders. The study examined the level and function of MAIT cells in patients with inflammatory bowel disease (IBD). Circulating MAIT cell levels were significantly reduced in IBD patients
-
Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors. J. Innate Immun. (IF 4.932) Pub Date : 2020-06-04 Gunnar Pejler
Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood. Mast cells are packed with secretory granules, and when they undergo degranulation in response to activation the contents of the granules are expelled to the extracellular milieu. Chymases, neutral serine proteases, are the major constituents
-
Natural Killer T Cells Are Numerically and Functionally Deficient in Patients with Trauma. J. Innate Immun. (IF 4.932) Pub Date : 2020-05-25 Young-Goun Jo,Jung-Chul Kim,Hye-Mi Jin,Young-Nan Cho,Seung-Jung Kee,Yong-Wook Park
Natural killer T (NKT) cells rapidly produce Th1 and Th2 cytokines such as interferon-γ (IFN-γ) and interleukin (IL)-4. This study examined the frequency and function of NKT cells in trauma patients. Frequencies, proliferative responses to α-galactosylceramide (α-GalCer), and Th1/Th2 cytokine secretion levels of NKT cells in peripheral blood mononuclear cells from trauma patients and healthy controls
-
-
COVID-19: Possible Impact of the Genetic Background in IFNL Genes on Disease Outcomes. J. Innate Immun. (IF 4.932) Pub Date : 2020-04-28 Sabine Mihm
J Innate Immun 2020;12:273–274
-
Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages. J. Innate Immun. (IF 4.932) Pub Date : 2020-04-14 Sander van Riet,Annemarie van Schadewijk,Steve de Vos,Nick Vandeghinste,Robbert J Rottier,Jan Stolk,Pieter S Hiemstra,Padmini Khedoe
Airway epithelial cells and macrophages participate in inflammatory responses to external noxious stimuli, which can cause epithelial injury. Upon injury, epithelial cells and macrophages act in concert to ensure rapid restoration of epithelial integrity. The nature of the interactions between these cell types during epithelial repair is incompletely understood. We used an in vitro human coculture
-
Humoral First-Line Mucosal Innate Defence in vivo. J. Innate Immun. (IF 4.932) Pub Date : 2020-03-23 Carl Persson
Based on observations in vivo in guinea-pig and human airways, this review presents plasma exudation as non-sieved transmission of bulk plasma across an unperturbed mucosa that maintains its normal barrier functions. Several steps have led to the present understanding of plasma exudation as a non-injurious response to mucosal challenges. The implication of a swift appearance of all circulating multipotent
-
Serious, Severe, Sepsis. J. Innate Immun. (IF 4.932) Pub Date : 2020-01-31 Heiko Herwald,Arne Egesten
J Innate Immun 2020;12:129–130
-
SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation. J. Innate Immun. (IF 4.932) Pub Date : 2020-01-14 Ariane Zutz,Christian Schölz,Stephanie Schneider,Virginia Pierini,Maximilian Münchhoff,Kathrin Sutter,Georg Wittmann,Ulf Dittmer,Rika Draenert,Johannes R Bogner,Oliver T Fackler,Oliver T Keppler
Classical antiviral restriction factors promote cellular immunity by their ability to interfere with virus replication and induction of their expression by proinflammatory cytokines such as interferons. The serine incorporator proteins SERINC3 and SERINC5 potently reduce the infectivity of HIV-1 particles when overexpressed, and RNA interference or knockout approaches in T cells have indicated antiviral
-
Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3. J. Innate Immun. (IF 4.932) Pub Date : 2019-12-20 Yang Liu,Chun-Fen Mo,Xing-Yan Luo,Hua Li,Hui-Jie Guo,Hai Sun,Song Hu,Li-Mei Li,Yan-Tang Wang,Shu-Xia Yang,Shan Chang,Qiang Zou
Toll-like receptor 3 (TLR3) is a sensor of endogenous cell necrosis during the process of acute inflammation. Interleukin (IL)-1 receptor antagonist (IL-1Ra) is an anti-inflammatory cytokine and can negatively regulate the pathogenesis of inflammation. However, whether and how activation of TLR3 can regulate IL-1Ra expression has not been clarified. Here, we show that poly(I:C) induces IL-1Ra expression
-
HSV-1/TLR9-Mediated IFNβ and TNFα Induction Is Mal-Dependent in Macrophages. J. Innate Immun. (IF 4.932) Pub Date : 2019-12-18 Joanna Zyzak,Małgorzata Mitkiewicz,Ewa Leszczyńska,Patryk Reniewicz,Paul N Moynagh,Jakub Siednienko
Innate immune response is a universal mechanism against invading pathogens. Toll-like receptors (TLRs), being part of a first line of defense, are responsible for detecting a variety of microorganisms. Among them TLR9, which is localized in endosomes, acts as a sensor for unmethylated CpG motifs present in bacteria, DNA viruses (e.g., HSV-1), or fungi. TLRs differ from one another by the use of accessory
-
Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases. J. Innate Immun. (IF 4.932) Pub Date : 2019-11-29 Charalambos Michaeloudes,Pankaj K Bhavsar,Sharon Mumby,Bingling Xu,Christopher Kim Ming Hui,Kian Fan Chung,Ian M Adcock
Lung innate immunity is the first line of defence against inhaled allergens, pathogens and environmental pollutants. Cellular metabolism plays a key role in innate immunity. Catabolic pathways, including glycolysis and fatty acid oxidation (FAO), are interconnected with biosynthetic and redox pathways. Innate immune cell activation and differentiation trigger extensive metabolic changes that are required
-
Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment. J. Innate Immun. (IF 4.932) Pub Date : 2019-11-19 Nikolai Siemens,Sonja Oehmcke-Hecht,Jörn Hoßmann,Sebastian B Skorka,Roel H T Nijhuis,Corinne Ruppen,Steinar Skrede,Manfred Rohde,Daniel Schultz,Michael Lalk,Andreas Itzek,Dietmar H Pieper,Christiaan J van den Bout,Eric C J Claas,Ed J Kuijper,Robert Mauritz,Parham Sendi,Herman F Wunderink,Anna Norrby-Teglund
A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19)
-
Innate Immune Evasion by Human Respiratory RNA Viruses. J. Innate Immun. (IF 4.932) Pub Date : 2019-10-14 Marjolein Kikkert
The impact of respiratory virus infections on the health of children and adults can be very significant. Yet, in contrast to most other childhood infections as well as other viral and bacterial diseases, prophylactic vaccines or effective antiviral treatments against viral respiratory infections are either still not available, or provide only limited protection. Given the widespread prevalence, a general
-
Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment. J. Innate Immun. (IF 4.932) Pub Date : 2019-10-01 Irina Korovina,Ales Neuwirth,David Sprott,Maria Troullinaki,David M Poitz,Andreas Deussen,Anne Klotzsche-von Ameln
Mononuclear phagocytes, such as macrophages and microglia, are key regulators of organ homeostasis including vascularization processes. Here, we investigated the role of the suppressor of cytokine signaling 3 (SOCS3) in myeloid cells as a regulator of mononuclear phagocyte function and their interaction with endothelial cells in the context of sprouting angiogenesis. As compared to SOCS3-sufficient
-
Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor. J. Innate Immun. (IF 4.932) Pub Date : 2019-09-27 Sandra T Persson,Simon Ekström,Praveen Papareddy,Heiko Herwald
Cold atmospheric plasma (CAP) has been demonstrated to be a successful antiseptic for chronic and infected wounds. Although experimental work has focused on elucidation of the curative power of CAP for wound healing, the molecular mechanisms behind this ability are less understood. To date, the direct effect of CAP on the activity of microbial virulence factors has not been investigated. In the present
-
Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus. J. Innate Immun. (IF 4.932) Pub Date : 2019-09-25 Gyöngyi Cinege,Zita Lerner,Lilla B Magyar,Bálint Soós,Renáta Tóth,Ildikó Kristó,Péter Vilmos,Gábor Juhász,Attila L Kovács,Zoltán Hegedűs,Christoph W Sensen,Éva Kurucz,István Andó
Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differentiate in Zaprionus indianus, an invasive species belonging to the vittiger subgroup
-
Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance. J. Innate Immun. (IF 4.932) Pub Date : 2019-09-17 Lloyd Tanner,Andrew Bruce Single
Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide. COPD is incurable, with current treatments only addressing associated symptoms and sometimes slowing its progression, thus highlighting
-
Tackling the Pros and Cons of Inflammation. J. Innate Immun. (IF 4.932) Pub Date : 2019-08-30 Heiko Herwald,Arne Egesten
-
Survivin Impairs the Apoptotic Machinery in CD4+ T Cells of Patients with Ulcerative Colitis. J. Innate Immun. (IF 4.932) Pub Date : 2019-07-22 Bai-Sui Feng,Na Ma,Yuan-Yi Zhang,Han Gao,Cui Zhang,Gengfeng Li,Zhanju Liu,Yisheng Feng,Hai-Qiong Yu,Liang Xiao,Zhi-Gang Liu,Ping-Chang Yang
BACKGROUND The increase in CD4+ T cell infiltration and overproduction of CD4+ T cell-associated cytokines have been observed in the inflamed colon mucosa of patients with ulcerative colitis (UC); the underlying mechanisms are not fully understood. Survivin plays a critical role in the interference with apoptotic machinery. This study aims to elucidate the role of survivin in the interference with
-
Long Noncoding RNA Linc00632 Inhibits Interleukin-13-Induced Inflammatory Cytokine and Mucus Production in Nasal Epithelial Cells. J. Innate Immun. (IF 4.932) Pub Date : 2019-07-17 Liyan Yue,Xiaoyan Yin,Fang Hao,Jinhui Dong,Xiumin Ren,Ou Xu,Chunguang Shan
Allergic rhinitis (AR) is an allergic disease characterized as (immunoglobulin E)-mediated type I hypersensitivity disorder. The interleukin-13 (IL-13) signaling pathway has been implicated in the pathogenesis of AR. In the present study, we investigated the regulatory role and mechanism of long noncoding RNA Linc00632 in IL-13-induced inflammatory cytokine and mucus production in nasal epithelial
-
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection. J. Innate Immun. (IF 4.932) Pub Date : 2019-07-03 Bryan van den Broek,Michiel van der Flier,Ronald de Groot,Marien I de Jonge,Jeroen D Langereis
Streptococcus pneumoniae and Neisseria meningitidis are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including
-
The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes. J. Innate Immun. (IF 4.932) Pub Date : 2019-07-02 Paul J McKiernan,Stephen G J Smith,Andrew L Durham,Ian M Adcock,Noel G McElvaney,Catherine M Greene
Compared to females, males are more susceptible to acute viral and other respiratory tract infections that display greater severity and higher mortality. In contrast, females tend to fare worse with chronic inflammatory diseases. Circulating 17β-estradiol (E2) is a female-specific factor that may influence the progression of human lung diseases. Here we hypothesize that E2 modulates the inflammatory
-
Efferocytosis of Apoptotic Neutrophils Enhances Control of Mycobacterium tuberculosis in HIV-Coinfected Macrophages in a Myeloperoxidase-Dependent Manner. J. Innate Immun. (IF 4.932) Pub Date : 2019-06-27 Anna-Maria Andersson,Marie Larsson,Olle Stendahl,Robert Blomgran
Tuberculosis remains a big threat, with 1.6 million deaths in 2017, including 0.3 million deaths among patients with HIV. The risk of developing active disease increases considerably during an HIV coinfection. Alveolar macrophages are the first immune cells to encounter the causative agent Mycobacterium tuberculosis, but during the granuloma formation other cells are recruited in order to combat the
-
The Specific Organism: Not Bacterial Gram Type: Drives the Inflammatory Response in Septic Shock. J. Innate Immun. (IF 4.932) Pub Date : 2019-06-26 Adam Linder,Chris D Fjell,Malin Inghammar,Joseph Hsu,Keith R Walley,John H Boyd,James A Russell
BACKGROUND AND HYPOTHESIS The inflammatory response was targeted by unsuccessful therapies but ignored pathogen. We hypothesized that the inflammatory response differs according to organism in human septic shock. MATERIALS AND METHODS We measured 39 cytokines at baseline and 24 h in patients (n = 363) in the Vasopressin and Septic Shock Trial (VASST). We compared cytokine profiles (cytokine functional
-
Mass Cytometry Reveals the Immaturity of Circulating Neutrophils during SIV Infection. J. Innate Immun. (IF 4.932) Pub Date : 2019-06-21 Julien Lemaitre,Antonio Cosma,Delphine Desjardins,Olivier Lambotte,Roger Le Grand
The infected host fails to eradicate HIV-1, despite significant control of viral replication by combinational antiretroviral therapy. Here, we assessed the impact of HIV infection on immune-cell compartments in a SIVmac251 nonhuman primate infection model, which allowed the choice of contamination route, time of infection, and treatment follow-up. We performed high-throughput multiparameter single-cell
-
Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations. J. Innate Immun. (IF 4.932) Pub Date : 2019-06-21 Karel G M Beenakker,Rudi G J Westendorp,Anton J M de Craen,Sijia Chen,Yotam Raz,Bart E P B Ballieux,Rob G H H Nelissen,Alexander F L Later,Tom W Huizinga,Pieternella E Slagboom,Dorret I Boomsma,Andrea B Maier
The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to sex differences in immune responsiveness. The aim of the present study was to investigate sex differences in monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide (LPS) using cytokine
-
The Microbiota: A Microbial Ecosystem Built on Mutualism Prevails. J. Innate Immun. (IF 4.932) Pub Date : 2019-06-20 Christoph Reinhardt
-
The Extracellular Matrix: Reloaded Revolutions. J. Innate Immun. (IF 4.932) Pub Date : 2019-06-05 Arne Egesten,Heiko Herwald
-
A Common Genetic Variation in Langerin (CD207) Compromises Cellular Uptake of Staphylococcus aureus. J. Innate Immun. (IF 4.932) Pub Date : 2019-05-29 Rob van Dalen,Felix F Fuchsberger,Christoph Rademacher,Jos A G van Strijp,Nina M van Sorge
Langerhans cells are key sentinel cells of the skin and mucosal lining. They sense microorganisms through their repertoire of pattern-recognition receptors to mount and direct appropriate immune responses. We recently demonstrated that human Langerhans cells interact with the Gram-positive pathogen Staphylococcus aureus through the Langerhans cell-specific receptor langerin (CD207). It was previously
-
Prostaglandin E2 Regulates Activation of Mouse Peritoneal Macrophages by Staphylococcus aureus through Toll-Like Receptor 2, Toll-Like Receptor 4, and NLRP3 Inflammasome Signaling. J. Innate Immun. (IF 4.932) Pub Date : 2019-05-29 Jindi Wu,Bo Liu,Wei Mao,Shuang Feng,Yuan Yao,Fan Bai,Yuan Shen,Amu Guleng,Bayin Jirigala,Jinshan Cao
Prostaglandin E2 (PGE2), an essential endogenous lipid mediator for normal physiological functions, can also act as an inflammatory mediator in pathological conditions. We determined whether Staphylococcus aureus lipoproteins are essential for inducing PGE2 secretion by immune cells and whether pattern recognition receptors mediate this process. PGE2 levels secreted by mouse peritoneal macrophages
-
Activation and Impaired Tumor Necrosis Factor-α Production of Circulating Mucosal-Associated Invariant T Cells in Patients with Trauma. J. Innate Immun. (IF 4.932) Pub Date : 2019-05-14 Young-Goun Jo,Hye-Mi Jin,Young-Nan Cho,Jung-Chul Kim,Seung-Jung Kee,Yong-Wook Park
Mucosal-associated invariant T (MAIT) cells rapidly produce proinflammatory cytokines in an innate-like manner and play an important role in controlling the host immune response. This study examined the function of MAIT cells in trauma patients. The expression of cytokines in peripheral blood MAIT cells was measured by flow cytometry. MAIT cells in trauma patients displayed impaired tumor necrosis
-
Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli. J. Innate Immun. (IF 4.932) Pub Date : 2019-05-03 Kathryn A Patras,Albert D Ha,Emma Rooholfada,Joshua Olson,Satish P Ramachandra Rao,Ann E Lin,Victor Nizet
Urinary tract infection (UTI) is a prominent global health care burden. Although UTI is readily treated with antibiotics in healthy adults, complicated cases in immune-compromised individuals and the emerging antibiotic resistance of several uropathogens have accelerated the need for new treatment strategies. Here, we surveyed the composition of urinary exosomes in a mouse model of uropathgenic Escherichia
-
Autophagy in Pulmonary Innate Immunity. J. Innate Immun. (IF 4.932) Pub Date : 2019-04-24 Lang Rao,N Tony Eissa
Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible
-
The Elusive Role of Placental Macrophages: The Hofbauer Cell. J. Innate Immun. (IF 4.932) Pub Date : 2019-04-10 Michael Z Zulu,Fernando O Martinez,Siamon Gordon,Clive M Gray
In this review, we discuss the often overlooked tissue-resident fetal macrophages, Hofbauer cells, which are found within the chorionic villi of the human placenta. Hofbauer cells have been shown to have a phenotype associated with regulatory and anti-inflammatory functions. They are thought to play a crucial role in the regulation of pregnancy and in the maintenance of a homeostatic environment that
-
TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms. J. Innate Immun. (IF 4.932) Pub Date : 2019-04-10 Jasmijn A Schrumpf,Dennis K Ninaber,Anne M van der Does,Pieter S Hiemstra
Airway epithelium is an important site for local vitamin D (VD) metabolism; this can be negatively affected by inflammatory mediators. VD is an important regulator of respiratory host defense, for example, by increasing the expression of hCAP18/LL-37. TGF-β1 is increased in chronic obstructive pulmonary disease (COPD), and known to decrease the expression of constitutive host defense mediators such
-
Salmonella and Reactive Oxygen Species: A Love-Hate Relationship. J. Innate Immun. (IF 4.932) Pub Date : 2019-04-03 Mikael Rhen
Salmonella enterica represents an enterobacterial species including numerous serovars that cause infections at, or initiated at, the intestinal epithelium. Many serovars also act as facultative intracellular pathogens with a tropism for phagocytic cells. These bacteria not only survive in phagocytes but also undergo de facto replication therein. Phagocytes, through the activities of phagocyte NADPH-dependent
-
Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus. J. Innate Immun. (IF 4.932) Pub Date : 2019-03-29 Azzeddine Dakhama,Reem Al Mubarak,Nicole Pavelka,Dennis Voelker,Max Seibold,Julie G Ledford,Monica Kraft,Liwu Li,Hong Wei Chu
The negative immune regulator Tollip inhibits the proinflammatory response to rhinovirus (RV) infection, a contributor to airway neutrophilic inflammation and asthma exacerbations, but the underlying molecular mechanisms are poorly understood. Tollip may inhibit IRAK1, a signaling molecule downstream of ST2, the receptor of IL-33. This study was carried out to determine whether Tollip downregulates
-
Anopheles stephensi Dual Oxidase Silencing Activates the Thioester-Containing Protein 1 Pathway to Suppress Plasmodium Development. J. Innate Immun. (IF 4.932) Pub Date : 2019-03-29 Parik Kakani,Mithilesh Kajla,Tania Pal Choudhury,Lalita Gupta,Sanjeev Kumar
We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding domain, seven transmembrane domains, and a C-terminal cytoplasmic NADPH domain. Phylogenetic
Contents have been reproduced by permission of the publishers.