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Animal models of lupus nephritis: the past, present and a future outlook Autoimmunity (IF 3.5) Pub Date : 2024-03-13 Divya Katikaneni, Laurence Morel, Yogesh Scindia
Lupus nephritis (LN) is the most severe end-organ pathology in Systemic Lupus Erythematosus (SLE). Research has enhanced our understanding of immune effectors and inflammatory pathways in LN. Howev...
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Identification of macrophage-related molecular subgroups and risk signature in colorectal cancer based on a bioinformatics analysis Autoimmunity (IF 3.5) Pub Date : 2024-03-11 Qi Liu, Li Liao
Macrophages play a crucial role in tumor initiation and progression, while macrophage-associated gene signature in colorectal cancer (CRC) patients has not been investigated. Our study aimed to ide...
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Functions of IgM fc receptor (FcµR) related to autoimmunity Autoimmunity (IF 3.5) Pub Date : 2024-03-11 Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as ...
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Integrated bioinformatics analysis identifies autophagy-associated genes as candidate biomarkers and reveals the immune infiltration landscape in psoriasis Autoimmunity (IF 3.5) Pub Date : 2024-03-04 Sixian Bai, Hongyu Cheng, Hao Li, Peng Bo
Autophagy is implicated in the pathogenesis of psoriasis. We aimed to identify autophagy-related biomarkers in psoriasis via an integrated bioinformatics approach. We downloaded the gene expression...
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CD5L induces inflammation and survival in RA-FLS through ERK1/2 MAPK pathway Autoimmunity (IF 3.5) Pub Date : 2024-02-29 Huiqing Yang, Yan Luo, Xiaofei Lai
To explore the effect of CD5-like molecule (CD5L) on rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) and the relative molecular mechanism of CD5L in it.Recombinant protein CD5L was ...
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Identification of new hub- ferroptosis-related genes in Lupus Nephritis Autoimmunity (IF 3.5) Pub Date : 2024-02-26 Xiao-Jie Zheng, Ying Chen, Li Yao, Xiao-Li Li, Da Sun, Yan-Qiu Li
Background: Lupus Nephritis (LN) is the primary causation of kidney injury in systemic lupus erythematosus (SLE). Ferroptosis is a programmed cell death. Therefore, understanding the crosstalk betw...
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Dysregulated CXCL12 expression in osteoblasts promotes B-lymphocytes preferentially homing to the bone marrow in MRL/lpr mice Autoimmunity (IF 3.5) Pub Date : 2024-02-25 Wenjuan Zheng, Yu Tang, Mengwei Cheng, Cui Ma, Xiaoming Fei, Wei Shi
Objective: Todetect the abnormal distribution of B-lymphocytes between peripheral and bone marrow (BM) compartments and explore the mechanism of abnormal chemotaxis of B-lymphocytes in lupus subjec...
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OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis Autoimmunity (IF 3.5) Pub Date : 2024-02-22 Chunlei He, Qiang Wu, Zhaogan Zeng, Yadong Yang, Huabin He, Meiyu Hu, Sheng Liu
The role of O-GlcNAc transferase (OGT)-induced O-linked N-acetylglucosaminylation (O-GlcNAcylation) has been reported in multiple human diseases. However, its specific functions in osteoarthritis (...
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Effects of autoimmune abnormalities on fertility and placental morphology in mice Autoimmunity (IF 3.5) Pub Date : 2024-02-22 Risa Yamanaka, Osamu Ichii, Teppei Nakamura, Yuki Otani, Takashi Namaba, Yasuhiro Kon
Autoimmune diseases (AIDs) alter the placental immune environment leading to fetal loss. This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ-Faslpr/lpr mi...
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Research progress in the construction of animal models of autoimmune thyroiditis Autoimmunity (IF 3.5) Pub Date : 2024-02-20 Ke Liu, Pei Zhang, Ling Zhou, Lin Han, Linhua Zhao, Xiaotong Yu
Autoimmune thyroiditis (AIT), also known as Hashimoto’s thyroiditis (HT), is an autoimmune disease that is characterised by elevated thyroid-specific antibody titres. The incidence of AIT is increa...
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Single-cell analysis with childhood and adult systemic lupus erythematosus Autoimmunity (IF 3.5) Pub Date : 2024-02-12 Jing Wang, Xiran Yang, Yanhua Zhang, Xuemei Jiang, Yanfang Li, Jingjing Cui, Yabin Liao
Patients with systemic lupus erythematosus (SLE), a heterogeneous and chronic autoimmune disease, exhibit unique changes in the complex composition and transcriptional signatures of peripheral bloo...
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Bioinformatics and systems-biology approach to identify common pathogenic mechanisms for COVID-19 and systemic lupus erythematosus Autoimmunity (IF 3.5) Pub Date : 2024-02-08 Yinlan Wu, Yanhong Li, Yu Zhou, Xiufeng Bai, Yi Liu
The Coronavirus disease 2019 (COVID-19) pandemic has brought a heavy burden to the world, interestingly, it shares many clinical symptoms with systemic lupus erythematosus (SLE). It is unclear whet...
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The role of NLRP3 inflammasome in type 2 inflammation related diseases Autoimmunity (IF 3.5) Pub Date : 2024-02-08 Shenming Xu, Dan Wang, Lina Tan, Jianyun Lu
Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse and affect multiple systems in the human body. It is common for individuals to have multi...
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Circ_0036490 and DKK1 competitively bind miR-29a to promote lipopolysaccharides-induced human gingival fibroblasts injury Autoimmunity (IF 3.5) Pub Date : 2024-02-07 Yeke Wu, Bin Li, Disi Deng, Hongling Zhou, Min Liu, Huangping Ai, Yilin Xin, Weihan Hua, Lixing Zhao, Li Li
MicroRNA (miRNA) plays a regulatory role in periodontitis. This study aimed to explore whether miR-29a could affect lipopolysaccharides (LPSs)-induced injury in human gingival fibroblasts (HGFs) th...
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Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis Autoimmunity (IF 3.5) Pub Date : 2024-01-22 Xiaomei Wang, Qiuyun Xue, Qiangjun Duan, Ziyi Sun, Yajie Wu, Shuo Yang, Pengfei Xu, Huibo Cao, Faxue Liao, Xiao Wang, Chenggui Miao
Our previous study found that Cullin 4B (CUL4B) inhibited rheumatoid arthritis (RA) pathology through glycogen synthase kinase-3beta (GSK3β)/canonical Wnt signalling pathway. In this work, pre-expe...
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CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1 Autoimmunity (IF 3.5) Pub Date : 2024-01-25 Xianzhao Cao, Hongyan Fang, Longshu Zhou
Circular RNA (circRNA) has been found to be differentially expressed and involved in regulating the processes of human diseases, including thoracic aortic dissection (TAD). However, the role and me...
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KISS-1 knockdown inhibits cell growth, migration, and invasion in HTR-8/SVneo cells by regulating the GRP54-mediated PI3K/AKT signaling pathway Autoimmunity (IF 3.5) Pub Date : 2023-12-28 Lingna Chen, Yuying Ruan, Liping Ni, Guiting Wang, Yajuan Gao, Jindi Zhang, Dingheng Li, Haiou Xu
Recurrent spontaneous abortions (RSA) affect reproductive health and increase the risk of subsequent abortions. To investigate the role of KISS-1/GPR-54 signaling in RSA progression. Villus tissue ...
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Interplay between COVID-19 and Secukinumab treatment in Spondylarthritis patients during the omicron surge: a retrospective cohort study Autoimmunity (IF 3.5) Pub Date : 2023-12-13 Tong Wu, Yanhong Li, Deying Huang, Yinlan Wu, Xiuping Liang, Lu Cheng, Zehui Liao, Fang Xu, Ye Chen, Jing Zhao, Zijing Xia, Chunyu Tan, Yi Liu, Martin Herrmann
The objective of this retrospective cohort study was to assess the relationship between Corona Disease 2019 (COVID-19) and Secukinumab treatment in patients with Spondylarthritis (SpA) in China dur...
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IL-10+CD19+ regulatory B cells induce CD4+Foxp3+regulatory T cells in serum of cervical cancer patients Autoimmunity (IF 3.5) Pub Date : 2023-12-12 Chunfeng Yang, Yuanyuan Zhang, Rui Wang, Bing Cheng, You Wu, Xi Fu
Increase of regulatory T cells (Tregs) in the tumour microenvironment predicts worse survival of patients with various types of cancer. Recently, B cells play a significant role in the maintenance ...
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Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress Autoimmunity (IF 3.5) Pub Date : 2023-11-27 Shu Tan, Hao Yu, Zhaocong Zhang, Yiming Liu, Ge Lou
Tumor-secreted exosomes are critical for the functional regulation of tumor-associated macrophages (TAMs). This study aimed to explore how exosomes secreted by ovarian carcinoma cells regulate the ...
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SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis Autoimmunity (IF 3.5) Pub Date : 2023-11-22 Xiaoyan Li, Sisi Tao, Zhiquan Xu, Yi Ren, Wei Xiang, Xiaojie He
Aggravated endoplasmic reticulum stress (ERS) and apoptosis in podocytes play an important role in lupus nephritis (LN) progression, but its mechanism is still unclear. Herein, the role of SMURF1 i...
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Circ_0006944 aggravates LPS-induced HK2 cell injury via modulating miR-205-5p/UBL4A pathway Autoimmunity (IF 3.5) Pub Date : 2023-11-22 Fan Zhou, Dong Liu, Junwei Ye, Bingqi Li
Circular RNAs (circRNAs) has been manifested to be involved in the development of human diseases, including sepsis-associated acute kidney injury (SA-AKI). However, the function and mechanism of ci...
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Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus Autoimmunity (IF 3.5) Pub Date : 2023-11-23 Mei-Ling Yang, TuKiet T. Lam, Jean Kanyo, Insoo Kang, Zhaohui Sunny Zhou, Steven G. Clarke, Mark J. Mamula
Protein posttranslational modifications (PTMs) arise in a number of normal cellular biological pathways and in response to pathology caused by inflammation and/or infection. Indeed, a number of PTM...
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TNF-α stimulated exosome derived from fibroblast-like synoviocytes isolated from rheumatoid arthritis patients promotes HUVEC migration, invasion and angiogenesis by targeting the miR-200a-3p/KLF6/VEGFA axis Autoimmunity (IF 3.5) Pub Date : 2023-11-17 Bin Zhang, Juanfang Gu, Yiwen Wang, Linfeng Guo, Jiangzhen Xie, Mingfeng Yang
The pathogenesis of rheumatoid arthritis (RA) is heavily impacted by the inflammation and activation of fibroblast-like synoviocytes (FLS). The objective of this investigation is to clarify the inv...
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CLDN1 silencing suppresses the proliferation and migration of airway smooth muscle cells by modulating MMP14 Autoimmunity (IF 3.5) Pub Date : 2023-11-15 Wei Li, Linyan Liu, Ming’ai Duanqing, Xiaoqing Xiong, Dejian Gan, Jin Yang, Mingya Wang, Min Zhou, Jun Yan
Airway remodeling is an important pathologic factor in the progression of asthma. Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) are important pathologic mechanisms in s...
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Potential significance of changes in serum levels of IL-17, TNF-α and DKK-1 in the progression of the rheumatoid arthritis Autoimmunity (IF 3.5) Pub Date : 2023-11-01 Qunxia Wang, Yanzhao Liu, Jiazhen Wu, Simei Chen, Tingting Hu, Yuhan Liu, Xu Li, Xiaohang Li, Yang Wu, Jianlin Yu, Tingting Zeng, Yi Luo, Xiaoyan Hu, Li-Ming Tan
To detect the value of serum interleukin-17 (IL-17), tumour necrosis factor-α (TNF-α), and Dickkopf-1 (DKK-1) in rheumatoid arthritis (RA) at different disease stages. 141 RA patients were randomly...
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Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137 Autoimmunity (IF 3.5) Pub Date : 2023-10-17 Dong Zheng, Kaiyuan Yang, Tong Chen, Songwei Lv, Liangliang Wang, Jianchao Gui, Chao Xu
Long-chain noncoding small nucleolar RNA host gene 14 (LncRNA SNHG14) is highly expressed in various diseases and promotes diseases progression, but the role and mechanism of LncRNA SNHG14 on targe...
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Circ_0035796 depletion inhibits transforming growth factor-β1-induced pulmonary fibrosis in a miR-150-5p/L1CAM-dependent manner Autoimmunity (IF 3.5) Pub Date : 2023-10-11 Juan Li, Xiaohong Chen, Baohong Zhang, Chenlu Wang
The pathogenesis of pulmonary fibrosis is not fully understood. Previous work has demonstrated the important role of circular RNA (circRNA) in pulmonary fibrosis development. This study aims to ana...
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Effects of Apelin on the fibrosis of retinal tissues and Müller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway Autoimmunity (IF 3.5) Pub Date : 2023-09-28 Yang Li, Qinrui Hu, Bin Wang
Retinal fibrosis was a key characteristic of diabetes retinopathy (DR). Apelin was found to be a candidate for tissue fibrosis. Nevertheless, the role of Apelin in the Müller cells in DR remains un...
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MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy Autoimmunity (IF 3.5) Pub Date : 2023-09-23 Huixiang Lu, Junnian Zhou, Xiaojun Li, Xiaoqin Han, Shuping Ma, Chunlan Feng
Lysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in ...
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The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases Autoimmunity (IF 3.5) Pub Date : 2023-09-23 Yunfei Li, Min Ming, Chunyang Li, Songpo Liu, Dan Zhang, Tao Song, Jun Tan, Jidong Zhang
The Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demo...
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Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment Autoimmunity (IF 3.5) Pub Date : 2023-09-22 Jingbo Zhang, Yiwei Guo, Huiying Fang, Xiuchen Guo, Lina Zhao
A novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explor...
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DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls Autoimmunity (IF 3.5) Pub Date : 2023-09-19 Sirpa Pahkuri, Ilse Ekman, Céline Vandamme, Kirsti Näntö-Salonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen
We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PT...
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Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF-β1-treated lung fibroblasts via sequestering miR-18a-5p Autoimmunity (IF 3.5) Pub Date : 2023-09-19 Ming Shen, Xinyi Wang, Xiaofeng Chang, Zhun Li, Na Jiang, Zhuoyue Han, Xin Liu
Circular RNAs (circRNAs) are functional molecules in all kinds of fibrosis diseases. The current study was performed for the exploration of circ_0007535 in pulmonary fibrosis. RNA levels for circ_0...
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CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis Autoimmunity (IF 3.5) Pub Date : 2023-09-19 Jian Zhong, Wei Zhang, Leiyun Zhang, Jieying Li, Lingkai Kang, Xiaoyue Li
Sepsis-induced acute respiratory distress syndrome (ARDS) remains a major complication of death from bacterial infection. Regulatory T cells (Tregs) are important regulators in addressing lung inju...
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SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19 Autoimmunity (IF 3.5) Pub Date : 2023-09-19 Alessandra Franco, Jaeyoon Song, Christina Chambers, Alessandro Sette, Alba Grifoni
We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-speci...
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Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues Autoimmunity (IF 3.5) Pub Date : 2023-09-14 Panagis Polykretis, Alberto Donzelli, Janci C. Lindsay, David Wiseman, Anthony M. Kyriakopoulos, Michael Mörz, Paolo Bellavite, Masanori Fukushima, Stephanie Seneff, Peter A. McCullough
Abstract As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display a wide distribution within the body, affecting
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Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma Autoimmunity (IF 3.5) Pub Date : 2023-08-25 Lei Bi, Cheng Ai, Hong Zhang, Zhengyu Chen, Yiping Deng, Jing Xiong, Zhongzhu Lv
Abstract Constituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing
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Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis Autoimmunity (IF 3.5) Pub Date : 2023-08-24 Zhongfeng Zhang, Wenyu Song, Run Yan
Abstract Lupus nephritis (LN) is a major cause death in patients with systemic lupus erythematosus. We aimed to find the differentially expressed genes (DEGs) in LN and confirm the regulatory mechanism on LN. The mouse model of LN was constructed by subcutaneous injection of pristane. RNA-seq screened 392 up-regulated and 447 down-regulated DEGs in LN mouse model, and KEGG analysis found that the top
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Proanthocyanidin A2 attenuates the activation of hepatic stellate cells by activating the PPAR-γ signalling pathway Autoimmunity (IF 3.5) Pub Date : 2023-08-24 Yacong Xiao, Xiujuan Li, Li Wang, Mingyue Hu, Youlin Liu
Abstract Liver fibrosis is the pathological process of chronic liver diseases induced by hepatic stellate cells. Proanthocyanidin A2 (PA2) has multiple pharmacological activities. In this study, we aimed to explore the effects of PA2 on hepatic stellate cell (HSC) activation in liver fibrosis. LX-2 cells were treated with TGF-β1 to establish a fibrosis cell model. Cell viability was evaluated using
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High-throughput autoantibody profiling of different stages of Schistosomiasis japonica Autoimmunity (IF 3.5) Pub Date : 2023-08-20 Xiaorong Zhou, Xi Wang, Jing Xu, Qi Tang, Robert Bergquist, Leming Shi, Zhiqiang Qin
Abstract Infection by the Schistosoma japonicum can result in acute, chronic and late-stage manifestations. The latter often presents with severe organ failures and premature death. Importantly, infection can also produce autoimmune phenomena reflected by the development of autoantibodies. We wished to explore and profile the presence of autoantibodies in sera of patients with different stages of S
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Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study Autoimmunity (IF 3.5) Pub Date : 2023-08-24 Qiaolin Wang, Sujie Jia, Qianjin Lu, Ming Zhao
Abstract As an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between
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Identification of prognostic biomarkers of breast cancer based on the immune-related gene module Autoimmunity (IF 3.5) Pub Date : 2023-08-16 Ruijuan Wang, Huanhong Zeng, Xueming Xiao, Junjie Zheng, Naizhuo Ke, Wenjun Xie, Qiang Lin, Hui Zhang
Abstract Breast cancer (BC) is highly malignant and its mortality rate remains high. The development of immunotherapy has gradually improved the prognosis and survival rate of patients. Therefore, identifying molecular markers concerned with BC immunity is of great importance for the treatment of this disease. The Cancer Genome Atlas-breast invasive carcinoma (TCGA-BRCA) was utilized as the training
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DNA polymerase ζ suppresses the radiosensitivity of glioma cells by regulating the PI3K/AKT/mTOR pathway Autoimmunity (IF 3.5) Pub Date : 2023-07-13 Jiqiang Ding, Zhisheng Chen, Weilong Ding, Yongsheng Xiang, Junbao Yang
Abstract Glioblastoma is the most common glioma with high mortality and poor prognosis. Radiation resistance is one of the large challenges in the treatment of glioma. The study aimed to identify whether DNA polymerase ζ affects glioma cell radiosensitivity. The mRNA and protein levels of REV3L and REV7 were examined using quantitative real-time PCR and western blot. After REV3L and REV7 knockdown
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The onset of de novo autoantibodies in healthcare workers after mRNA based anti-SARS-CoV-2 vaccines: a single centre prospective follow-up study Autoimmunity (IF 3.5) Pub Date : 2023-06-28 M.C Sacchi, C. Pelazza, M. Bertolotti, L. Agatea, P. De Gaspari, S. Tamiazzo, D. Ielo, P. Stobbione, M. Grappiolo, T. Bolgeo, P. Novel, M.M Ciriello, A. Maconi
Abstract Nowadays, data concerning the risk of autoimmune disease after SARS-CoV-2 (COVID-19) vaccination is controversial. The aim of this single centre prospective follow-up study was to evaluate whether healthcare workers (HCWs) vaccinated with BNT162b2 mRNA and mRNA-1273 will show a development and/or a persistence of autoantibodies, focussing on the detection of antibodies against nuclear antigens
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Patients with dermatomyositis shared partially similar transcriptome signature with COVID-19 infection Autoimmunity (IF 3.5) Pub Date : 2023-06-23 Yiying Yang, Jie Song, Hongjun Zhao, Huali Zhang, Muyao Guo
Abstract Dermatomyositis (DM) is an autoimmune disease that primarily affects the skin and skeletal muscle. Virus infection and type I interferon-related signaling pathways play an important role in the pathogenesis of dermatomyositis. In this study, we found that the skin of patients with DM and the skin of patients with COVID-19 have similar transcriptional profiles, and identified key genes involved
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miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis Autoimmunity (IF 3.5) Pub Date : 2023-06-14 Rong Yan, Xinghua Liang, Juan Hu
Abstract Ulcerative colitis (UC) is a chronic and recurrent inflammatory disease of the colon that result in the destruction and inflammation of the colonic mucosa. Current research has established a strong correlation between pyroptosis of colonic epithelial cells and the onset and progression of UC. In addition, miRNAs have been implicated in the development and progression of UC and pyroptosis.
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GADD45B predicts lung squamous cell carcinoma survival and impacts immune infiltration, and T cell exhaustion Autoimmunity (IF 3.5) Pub Date : 2023-05-11 Ying Lv, Zeyu Liu, Kai Xiong, Hailing Duan, Jiuyu Yang, Pan Liao
Abstract Background: This study focussed on exploring the prognostic prediction performance of the growth arrest and DNA damage-inducible 45 beta (GADD45B) and its associations with T-cell activity and immune soakage in different malignancies, especially lung squamous cell carcinoma (LUSC). Methods: We applied TIMER database for comparing the expressions of GADD45B among different cancers. OncoLnc
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Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway Autoimmunity (IF 3.5) Pub Date : 2023-05-03 Peiting Li, Ying Huang, Ju Wang, Jiashun Zeng, Long Li
Abstract Rheumatoid arthritis (RA) displays very similar characteristics to those of tumor cells, platycodin D (PD) is a triterpenoid saponin abundant in Platycodon grandiflorum (PG), plays an important role in the inhibition of tumor growth. Our previous experiments confirmed that PD inhibited MH7A cell proliferation and migration, but it’s possible mechanism remain unclear. This study aimed to reveal
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Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues Autoimmunity (IF 3.5) Pub Date : 2023-04-26 Qianwen Qiu, Xiufeng Yu, Qingli Chen, Xuwei He
Abstract Semaphorin 3A (Sema3A) is a secretory member of the semaphorin family of immune response regulators. This research focuses on its effects on inflammation and oxidative stress in acute respiratory distress syndrome (ARDS). By analysing the GEO dataset GSE57011, we obtained Sema3A as the most downregulated gene in ARDS samples. Lipopolysaccharide (LPS) was used to stimulate rat pulmonary microvascular
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Highly-expressed circ_0129657 inhibits proliferation as well as promotes apoptosis and inflammation in HBMECs after oxygen-glucose deprivation via miR-194-5p/GMFB axis Autoimmunity (IF 3.5) Pub Date : 2023-04-19 Yun Qian, Bo Tang, Hao Zhang, Hui Yang
Abstract Stroke is an acute cerebrovascular disease that is now the most important cause of death due to brain problems in our country. CircRNAs are RNA circles that have been extensively involved in the disease. We aimed to investigate the mechanism of circ_0129657 in the pathogenesis of stroke. In this study, quantitative real-time polymerase chain reaction (RT-qPCR) and western blot assays were
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LncRNA DGCR5/miR-204-5p/SRSF7 axis regulates PDGF-BB-induced proliferation and migration of airway smooth muscle cells with potential role in asthma Autoimmunity (IF 3.5) Pub Date : 2023-04-17 Ting Zhou, Xiong Chen, Xin Feng
Abstract Increased proliferation and migration of abnormal airway smooth muscle cells (ASMCs) are significantly associated with asthma. Recently, the function of long non-coding RNAs (lncRNAs) in ASMCs has been identified. Our research attempted to resolve the function of the lncRNA DGCR5 in ASMCs and focus on its in-depth mechanisms of proliferation and migration. Quantitative real-time PCR and western
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RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway Autoimmunity (IF 3.5) Pub Date : 2023-03-31 Yurong Zhu, Jun Li, Tao Ba, Yuan Sun, Xiangyun Chang
Abstract Impaired insulin secretion due to pancreatic β-cell injury is an important cause of type 2 diabetes (T2D). Regulators of guanine nucleotide binding protein (G protein) signaling proteins played a key role in regulating insulin sensitivity in vivo. To explore the role of RGS7 on palmitic acid-induced pancreatic β-cell injury, pancreatic β-cells Beta-TC-6 and Min6 were treated with palmitic
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Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus Autoimmunity (IF 3.5) Pub Date : 2023-03-26 Ya Li, Juan Chen, Min Xie, Yihui Cao, Yan Zhou, Ruixian Zhang
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. At present, the mechanism of non-coding RNA in renal injury in SLE patients is still unclear. A total of 64 DEcircRNAs, 75 DEmiRNAs, and 249 DEmRNAs were identified. We integrated 10 circRNAs, 10 miRNAs, and 88 target mRNAs into a circRNA-miRNA-mRNA network and obtained 9 hub genes (circ-0000006, miR-766-3p, miR-409-3p, miR-339-3p
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LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway Autoimmunity (IF 3.5) Pub Date : 2023-03-21 Yuan Sun, Hui Jiang, LingYu Pan, YanQuan Han, Yan Chen, Yeke Jiang, Yongzhong Wang
Abstract LncRNA OIP5-AS1 has a common gene imbalance in various cancers and tumours, which plays an important role in regulating its biological function. However, there are few studies on lncRNA OIP5-AS1 in rheumatoid arthritis (RA). The purpose of the present study was to investigate the role of lncRNA OIP5-AS1 in the pathogenesis of RA. In the present study, we established an adjuvant arthritis (AA)
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Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis Autoimmunity (IF 3.5) Pub Date : 2023-03-21 Zhihong Xia, Bo Hu, Min Yang, Wenjie He
Abstract The factors regulating the heterogeneity of interleukin-17A (IL-17A)-expressing CD4+ T cells in inflammatory bowel diseases remain unclear. In the current study, we characterised the expression and function of zinc finger protein 189 (ZFP189) in a murine colitis model. Mice were given dextran sulphate sodium to induce acute colitis. Flow cytometry was applied to recognise and enrich Th17 and
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Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis Autoimmunity (IF 3.5) Pub Date : 2023-03-20 Xia Ke, Ziqi Chen, Xiaoqiang Wang, Houyong Kang, Suling Hong
Abstract Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological activity in AR. Here, we aimed to explore the effects of quercetin on type 1 helper T (Th1)/Th2 and regulatory T cells (Treg)/Th17 balance. We established an ovalbumin (OVA)-induced mouse model and orally administered 20, 35, and 50 mg/kg/day quercetin. The nasal symptoms
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NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation Autoimmunity (IF 3.5) Pub Date : 2023-03-15 Xiaofan Chen, Weidong Li, Chengdong Chang
Abstract Nuclear receptor subfamily 3 group C member 2 (NR3C2) has been revealed to affect the progression of multiple inflammatory diseases, while NR3C2’s efficacy in coronary artery disease (CAD) remains largely unsolved. The study intended to elucidate the possible mechanisms of NR3C2 in oxidised low density lipoprotein (ox-LDL)-induced inflammation in human coronary endothelial cells (HCAECs) via
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Serum sirtuin-1 a potential marker in the diagnosis of rheumatoid arthritis Autoimmunity (IF 3.5) Pub Date : 2023-02-26 Liming Tan, Tanglin Ouyang, Xu Li, Yinyi Chen, Shipeng Ke, Jiayuan Chen, Ye Liu, Fajun Zeng, Yingxing Chen, Jing Long, Qingyue Deng, Xiaoyan Hu
Abstract Introduction: To explore the value of serum sirtuin-1 (SIRT1) in the diagnosis and evaluation of joint mobility of rheumatoid arthritis (RA). Materials and Methods: Serum was randomly obtained from 212 RA patients,210 non-RA patients and 58 healthy controls in a large tertiary first-class hospital in Jiangxi province from November 2021 to June 2022. The level of serum Sirt1,anti-cyclic citrulline
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Endonuclease G promotes preeclampsia by regulating the Wnt signaling pathway Autoimmunity (IF 3.5) Pub Date : 2023-02-28 Jing Yang, Xuejun Kou
Abstract This study was conducted to investigate the effect and underlying mechanism of endonuclease G (ENDOG) on preeclampsia (PE). Differentially expressed genes in four Gene Expression Omnibus datasets (GSE147776, GSE96984, GSE102897, and GSE65271) were identified using a Venn diagram. Normal and PE placental tissues were collected from normal and PE parturients. The expression of ENDOG in tissues