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Differential synovial tissue expression of TLRs in seropositive and seronegative rheumatoid arthritis: A preliminary report Autoimmunity (IF 2.125) Pub Date : 2020-12-30 Alzahraa Abdelwahab; Sanna Palosaari; Soha Abdelkawy Abdelwahab; Rehab Ahmed Rifaai; Nashwa Fathy El-Tahawy; Entesar Ali Saber; Tomi Nousiainen; Maarit Valkealahti; Johanna Huhtakangas; Tuomo J. Karttunen; Petri Lehenkari
Abstract Toll-like receptors (TLRs) are known to have an important role in triggering the innate immune response and in priming antigen-specific adaptive immunity and inflammation. The differences in synovial tissue expression of the TLRs between seronegative and seropositive rheumatoid arthritis (RA) were examined from 9 seropositive RA, 5 seronegative RA and 4 osteoarthritis (OA) patients. Synovitis
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Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation Autoimmunity (IF 2.125) Pub Date : 2020-12-04 Cao Yongjun; Qiao Nan; Sun Yumeng; Jin Xiaowen; Wen Weibo
Abstract Dioscin has been used as a treatment for Hashimoto’s thyroiditis (HT) in China. However, the molecular mechanisms governing the modes of action of dioscin have not been elucidated. In this study, flow cytometry and Western blotting were used to identify the proportions of CD4+CD25+ regulatory T (Treg) cells and the expression of forkhead box P3 (Foxp3) and SUMO-specific protease 1 (SENP1)
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Clinical implication and immunological characterisation of the ARF-GEF family member CYTH4 in ovarian cancer Autoimmunity (IF 2.125) Pub Date : 2020-10-20 Qinyi Zhang; Qingying Wang; Sufang Wu; Jiawen Zhang
Abstract Background The GTP exchange factors on ADP-ribosylation factor (ARF) mediate the GDP/GTP exchange on ARF, serve as regulators in protein trafficking and membrane dynamics, and play critical roles in various cell processes. However, the relationship between the expression of ARF-GEF family genes and clinical implications in ovarian cancer remains unclear. Methods We performed a systematic investigation
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LncRNA TUG1 positively regulates osteoclast differentiation by targeting v-maf musculoaponeurotic fibrosarcoma oncogene homolog B Autoimmunity (IF 2.125) Pub Date : 2020-11-04 Ya-jing Du; Qiong-qiong Yu; Xiao-fei Zheng; Su-ping Wang
Abstract Osteoclast differentiation-mediates bone resorption is the key biological basis of orthodontic treatment while the specific mechanism of osteoclastogenesis remains unclear. This study aims to explore the underlying mechanism of the osteoclast differentiation from the perspective of long non-coding RNA (LncRNA). In the present study, the osteoclast differentiation of CD14+ peripheral blood
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Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis Autoimmunity (IF 2.125) Pub Date : 2020-10-21 Zhi-Ming Wu; Jun Luo; Xiao-Dong Shi; Shao-Xin Zhang; Xiao-Bo Zhu; Jian Guo
Abstract Rheumatoid arthritis (RA) is considered to be a chronic autoimmune disease, pathogenesis of RA is complex and effective treatments for RA is still lacking. Previous studies found that microRNAs (miRNAs) play important roles in the pathogenesis of RA, and miR-223-3p is considered to be one of the possible biomarkers of RA. Recent studies have revealed that icariin alleviates RA in murine models
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Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice Autoimmunity (IF 2.125) Pub Date : 2020-10-21 Ahmad A. Al Robaee; Abdullateef A. Alzolibani; Zafar Rasheed
Abstract Regulation of melanogenesis by tyrosinase has now become an attractive approach for treatment of vitiligo but still the role of tyrosinase in the induction of depigmentation remains largely unexplored. This study was explored the role of tyrosinase in the induction of autoimmune depigmentation in C57BL/6 mice. Depigmentation was induced in C57BL/6 mice by tyrosinase immunization. Induced depigmentation
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DL-propargylglycine administration inhibits TET2 and FOXP3 expression and alleviates symptoms of neonatal Cows’ milk allergy in mouse model Autoimmunity (IF 2.125) Pub Date : 2020-10-20 Beibei Sun; Dongjin Feng; Guangmeng Wang; Xiaohong Yu; Zhongmao Dong; Ling Gao
Abstract Background Cows’ milk allergy (CMA) is a hypersensitivity immune reaction brought on by specific immunologic mechanisms to cow’s milk proteins. As one of the most common food allergies in infants, the incidence of CMA during the first year of life is estimated to be nearly 7.5%. Due to the limitation in the knowledge of the pathological mechanism underlying CMA, however, the clinical interventions
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IgA autoantibodies directed against self DNA are elevated in cystic fibrosis and associated with more severe lung dysfunction Autoimmunity (IF 2.125) Pub Date : 2020-12-01 Ruchi Yadav; Rachel W. Linnemann; Joanne Michelle Kahlenberg; Louis S. Bridges Jr; Arlene A. Stecenko; Balázs Rada
Abstract Although extracellular host DNA (ecDNA) levels in CF airways were linked to airflow obstruction and recombinant DNAse therapy is beneficial for CF patients, it remains incompletely understood whether ecDNA also leads to an autoimmune response. Here we hypothesized that chronic presence of DNA in CF airways triggers the production of autoantibodies targeting host human DNA. We measured the
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Evaluation of the diagnostic performance of an immunoblot for ANCA and anti-GBM antibody detection Autoimmunity (IF 2.125) Pub Date : 2020-11-20 Matthias H. Busch; Joop P. Aendekerk; Joyce J. B. C. van Beers; Pieter van Paassen; Jan G. M. C. Damoiseaux
Abstract The use of high-quality antigen-specific immunoassays for detecting anti-neutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies is recommended in patients with suspected ANCA vasculitis and/or anti-GBM disease. We analysed the diagnostic performance of a semi-quantitative and rapid immunoblot (EUROIMMUN AG, Lübeck, Germany) in two settings. Patient
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LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis Autoimmunity (IF 2.125) Pub Date : 2020-11-20 Zhou Yang; Shu-Dian Lin; Feng Zhan; Ying Liu; Yu-Wei Zhan
Abstract Introduction Rheumatoid arthritis (RA) is an autoimmune disease that affects millions of people. Fibroblast-like synoviocytes (FLSs) located in rheumatoid panni play a pivotal role in the formation of RA. The long noncoding RNA (lncRNA) GAS5 is reportedly downregulated in rheumatoid arthritis. However, its detailed mechanism in RA remains to be explored. This study investigated the roles and
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Differential mitochondrial genome in patients with Rheumatoid Arthritis Autoimmunity (IF 2.125) Pub Date : 2020-11-15 Kumar Sagar Jaiswal; Shweta Khanna; Arup Ghosh; Prasanta Padhan; Sunil Kumar Raghav; Bhawna Gupta
Abstract Background Mitochondria play an important role in cell survival, function and lineage differentiation. Changes in mitochondrial DNA (mtDNA) may control mitochondrial functions and thus may impart an alternative cellular state thereby leading to a disease condition in the body. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease wherein immune cells become self-reactive causing
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Nanostructured lipid carrier-based smart gel: a delivery platform for intra-articular therapeutics Autoimmunity (IF 2.125) Pub Date : 2020-11-12 Chetan Shinde; Madhugiri Prakash Venkatesh; Tegginmat Pramod Kumar; Deeksha Ramananda Pai
Abstract The promising potential of nano-structured lipid carrier (NLC) polymeric gel of CUR as an effective treatment for rheumatoid arthritis by intra-articular route of administration was investigated. NLC composed of cetylpalmitate, Labrafac PG & Captex 200, Tween 80 and Labrasol. The hot homogenization method employed by melt ultrasonication was used. The formulated NLC dispersions were characterized
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Expression of zinc transporter 8 in thyroid tissues from patients with immune and non-immune thyroid diseases. Autoimmunity (IF 2.125) Pub Date : 2020-09-08 Artur Bossowski,Karolina Stożek,Marta Rydzewska,Wiesława Niklińska,Marta Gąsowska,Dariusz Polnik,Mieczysław Szalecki,Agnieszka Mikłosz,Adrian Chabowski,Joanna Reszeć
Abstract Introduction Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet autoantigen in type 1 diabetes. Materials and methods We studied the expression
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Auto-reactivity against gut bacterial peptides in patients with late-onset diabetes. Autoimmunity (IF 2.125) Pub Date : 2020-09-14 Mohammad Sajid,Krishna Biswas,Harpreet Singh,Sapna Negi
Abstract The depletion of gut mucosal barrier enables exposure of gut microbes/gut microbial products to the host mucosal immunity which may increase the risk of metabolic/inflammatory disorders. These immune responses can lead to the development of mild autoimmunity to metabolic peptides coming from gut bacteria and may result in metabolic diseases like late-onset diabetes (LOD). In the present study
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The clinical characteristics of autoimmune haemolytic anaemia/Evans syndrome patients with clonal immunoglobulin/T cell receptor gene rearrangement. Autoimmunity (IF 2.125) Pub Date : 2020-09-14 Hongli Zhu,Manjun Zhao,Zeng Cao,Jin Yang,Yi Li,Limin Xing
Abstract Objective To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. Methods Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study. Clinical characteristics were analyzed and compared between patients with and without clonal Ig/TCR gene rearrangement. Results Clonal Ig/TCR rearrangements were identified
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Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis. Autoimmunity (IF 2.125) Pub Date : 2020-08-21 Cristhine Pieczarka,Fabiana Antunes Andrade,Sandra Jeremias Catarino,Kárita Cláudia Freitas Lidani,Lorena Bavia,Regina Tizzot,Thelma Skare,Iara Jose de Messias-Reason
Abstract Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns, apoptotic cells, and cellular debris mediating the clearance by phagocytes. High ficolin-1 and ficolin-3 levels have been observed in RA patients
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Associations of genetic polymorphisms within MALAT1, UCA1, FAM211A-AS1 and AC000111.6 with genetic susceptibility to rheumatoid arthritis. Autoimmunity (IF 2.125) Pub Date : 2020-09-10 Zhen Zhang,Wei Zhang,Qin-Wen Wen,Ting-Hui Wang,Wen Qin,Hua Huang,Yi-Jun Mo,Xiu-Di Wu,Han Cen
Abstract Recently, several long non-coding RNAs (lncRNAs) including MALAT1, UCA1, ENST00000483588, and ENST00000456270 have been implicated in the pathogenesis of rheumatoid arthritis (RA), and we hypothesized that polymorphisms within these lncRNA genes might be genetic modifiers for the development of RA. A total of 10 potentially functional single-nucleotide polymorphisms (SNPs) were selected and
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Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice. Autoimmunity (IF 2.125) Pub Date : 2020-09-09 Lichchavi D Rajasinghe,Quan-Zhen Li,Chengsong Zhu,Mei Yan,Preeti S Chauhan,Kathryn A Wierenga,Melissa A Bates,Jack R Harkema,Abby D Benninghoff,James J Pestka
Abstract Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that triggers interferon-regulated gene expression, ectopic lymphoid structure (ELS) development, elevation of local and systemic autoantibodies (AAbs)
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Identification of differentially expressed and methylated genes associated with rheumatoid arthritis based on network. Autoimmunity (IF 2.125) Pub Date : 2020-07-10 Di Zhang,ZhaoFang Li,RongQiang Zhang,XiaoLi Yang,DanDan Zhang,Qiang Li,Chen Wang,Xuena Yang,YongMin Xiong
Rheumatoid arthritis (RA) is a multi-systemic inflammatory autoimmune disease involving peripheral joints, and the pathogenesis is not clear. Studies showed that DNA methylation and expression might also be involved in the pathogenesis of RA. This study integrated three expression profile datasets (GSE55235, GSE12021, and GSE55457) and one methylation profile dataset GSE111942 to elucidate the potential
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MicroRNA-340-5p suppressed rheumatoid arthritis synovial fibroblast proliferation and induces apoptotic cell number by targeting signal transducers and activators of transcription 3. Autoimmunity (IF 2.125) Pub Date : 2020-07-24 Shibin Zhang,Tingting Meng,Chunzhi Tang,Shengdong Li,Xudong Cai,Dawei Wang,Min Chen
Rheumatoid arthritis is a chronic systemic autoimmune disease. In this study, the role of microRNA-340-5p in rheumatoid arthritis was investigated. qRT-PCR was used to detect the expression of microRNA-340-5p in serums, synovial tissues, and fibroblast-like synoviocytes from patients and healthy participants. Cell proliferation rate, cell cycle and apoptotic cell numbers were measured by CCK-8 and
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Expression of NGAL-specific cells and mRNA levels correlate with inflammation in the salivary gland, and its overexpression in the saliva, of patients with primary Sjögren's syndrome. Autoimmunity (IF 2.125) Pub Date : 2020-07-20 Lara A Aqrawi,Janicke Liaaen Jensen,Siren Fromreide,Hilde Kanli Galtung,Kathrine Skarstein
Salivary gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by infiltrating immune cells, and may be accompanied by the presence of adipose tissue. Optimally diagnosing this multifactorial disease requires the incorporation of additional routines. Screening for disease-specific biomarkers in biological fluid could be a promising approach
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Whole-exome sequencing in three children with sporadic Blau syndrome, one of them co-presenting with recurrent polyserositis. Autoimmunity (IF 2.125) Pub Date : 2020-06-29 Carlos Córdova-Fletes,Martha M Rangel-Sosa,Lizeth A Martínez-Jacobo,Luis Eduardo Becerra-Solano,Carmen Araceli Arellano-Valdés,José Alberto Tlacuilo-Parra,Kame Alberto Galán-Huerta,Ana María Rivas-Estilla,Angélica Alejandra Hernandez-Orozco,José Elías García-Ortiz
Blau syndrome (BS) is a rare, chronic autoinflammatory disease with onset before age 4 and mainly characterised by granulomatous arthritis, recurrent uveitis, and skin rash. Sporadic (also known as early-onset sarcoidosis) or familial BS is caused by gain-of-function mutations in the NOD2 gene, which encodes for a multi-task protein that plays a crucial role in the innate immune defense. We report
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Metformin reduces autoimmune antibody levels in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Autoimmunity (IF 2.125) Pub Date : 2020-08-01 Xi Jia,Tianyu Zhai,Jin-An Zhang
Background In the past few years, an increasing number of studies have proposed the idea of extending the therapeutic range of metformin from traditional hypoglycaemic to autoimmune diseases, and confirmed in a variety of autoimmune diseases. However, whether metformin can be used to treat Hashimoto’s thyroiditis (HT), which is characterised by thyroid peroxidase antibody (TPOAb) and thyroglobulin
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Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine. Autoimmunity (IF 2.125) Pub Date : 2020-07-14 Johanna Galaski,Anja C Koop,Marc Lütgehetmann,Ansgar W Lohse,Christina Weiler-Normann
In vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as “rods and rings” (RR) patterns by immunofluorescence. In vivo, autoantibodies to RR have been almost exclusively
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Silent red blood cell autoantibodies: Are they naturally occurring or an effect of tolerance loss for a subsequent autoimmune process? Autoimmunity (IF 2.125) Pub Date : 2020-08-20 Honorio Torres-Aguilar,Sorely Adelina Sosa-Luis,William de Jesús Ríos-Ríos,María de Los Ángeles Romero-Tlalolini,Sergio Roberto Aguilar-Ruiz
Abstract Unexpected anti-red blood cell (RBC) alloantibodies are routinely investigated in immunohematology and blood banking since their existence in pregnant women may induce haemolytic disease of the foetus and newborn, and their presence in donors may induce haemolytic transfusion reactions or hyperacute rejection in solid organ transplantation. Unexpected anti-RBC alloantibodies may target antigens
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Identification of antigen-specific neutrophils in the tonsils with recurrent acute inflammation. Autoimmunity (IF 2.125) Pub Date : 2020-06-11 Cai-Jie Zhou,Li-Hua Mo,Xiang-Qian Luo,Gui Yang,Wei-Liang Diao,Shi-Ping Hu,Ping-Chang Yang
The pathogenesis of recurrent acute tonsillitis (Rtn) is to be further investigated. Polymorphonuclear neutrophils (PMN) often associate with the pathogenesis of acute and chronic inflammation. This study aims to identify the antigen-specific PMNs (sPMNs) isolated from the tonsillar tissues with recurrent acute inflammation. In this study, CD66b+ PMNs were isolated from surgically removed tonsils (40
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Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition. Autoimmunity (IF 2.125) Pub Date : 2020-05-25 Brij B Singh,Joyce Ohm,Fredice O Quenum Zanbede,Pooja Chauhan,Frans G M Kroese,Arjan Vissink,Julian L Ambrus,Bibhuti B Mishra
Abstract Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could promote these changes in salivary gland tissue in pSS is not yet determined. Herein, we provide evidence that loss of alpha-1 antiproteinase antitrypsin could
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Enhanced expression of human endogenous retroviruses in new-onset type 1 diabetes: Potential pathogenetic and therapeutic implications. Autoimmunity (IF 2.125) Pub Date : 2020-06-25 Pier-Angelo Tovo,Ivana Rabbone,Davide Tinti,Ilaria Galliano,Michela Trada,Valentina Daprà,Franco Cerutti,Massimiliano Bergallo
Human endogenous retroviruses (HERVs) have been studied and proposed as relevant cofactors in several autoimmune diseases, including type 1 diabetes (T1D), though with controversial results and no study at disease onset. In order to gather further information on the potential role of HERVs in the development of T1D we assessed the transcription levels of pol genes of HERV-H, HERV-K, and HERV-W in peripheral
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CXCL4 promoted the production of CD4+CD25+FOXP3+treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway. Autoimmunity (IF 2.125) Pub Date : 2020-06-13 Tao Xu,Jie Zhao,Xiaolin Wang,Yan Meng,Zhenzhen Zhao,Rui Bao,Xiaoming Deng,Jinjun Bian,Tao Yang
Background: CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis. Methods: Sepsis model was constructed on mouse. Flow cytometry was used to determine the ratio of CD4+CD25+FOXP3+Treg cells. ELISA assays were used to determine
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Feeding lactobacilli impacts lupus progression in (NZBxNZW)F1 lupus-prone mice by enhancing immunoregulation. Autoimmunity (IF 2.125) Pub Date : 2020-06-19 Jean N Manirarora,Michele M Kosiewicz,Pascale Alard
Although the relationship between autoimmunity and microorganisms is complex, there is evidence that microorganisms can prevent the development of various autoimmune diseases. Lactobacilli are beneficial gut bacteria that play an important role in immune system development. The goals of this study were to assess the ability of three different strains of lactobacilli (L. casei B255, L. reuteri DSM 17509
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LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor β1. Autoimmunity (IF 2.125) Pub Date : 2020-06-16 Yang Wang,Guoqing Li,Wentao Guo,Baochao Ji,Aishajiang Aisikeerbayi,Yelborati Boratibai,Li Cao
LncRNA PlncRNA-1(PlncRNA-1) participates in breast cancer by upregulating TGF-β1. It is known that TGF-β1 plays an inhibitory role in the inflammatory responses in rheumatoid arthritis (RA). Therefore, PlncRNA-1 may also participate in RA. Serum and synovial fibroblasts were obtained from 34 patients with active RA (persistent symptoms), 36 patients with inactive RA (long term of no or few symptoms
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Correction. Autoimmunity (IF 2.125) Pub Date : 2020-05-26
(2020). Correction. Autoimmunity: Vol. 53, No. 6, pp. 366-366.
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Soluble PD1 levels are increased with disease activity in paediatric onset autoimmune hepatitis and inflammatory bowel disease. Autoimmunity (IF 2.125) Pub Date : 2020-05-06 Timothy Hadley,Scott Gillespie,Hillary Espinoza,Jarod Prince,Henning Gronbaek,Shanmuganathan Chandrakasan,Subra Kuguthasan,Vasantha L Kolachala,Nitika A Gupta
Introduction: Immune mediated liver diseases entail a broad category which are associated with increased morbidity and mortality amongst the paediatric population. Programmed Death 1 (PD1) is an inhibitory receptor mainly expressed by T cells, and when activated shed into plasma as soluble PD1(sPD1). The AIM of this study was to evaluate sPD1 levels in plasma of paediatric patients with Autoimmune
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Autoantibodies against the autophagic protein microtubule-associated light-chain 3 (LC3): Immunocharacterization of an atypical ANA pattern. Autoimmunity (IF 2.125) Pub Date : 2020-04-27 Emilia Maellaro,Lucia Terzuoli,Maria Romana Bacarelli,Barbara Del Bello,Nicola Bizzaro,Brunetta Porcelli
Autoantibodies to nuclear and cytoplasmic antigens are commonly detected by indirect immunofluorescence (IIF) on HEp-2 cells, and three major staining patterns (nuclear, cytoplasmic, and mitotic) are distinguished. Here, we report an atypical cytoplasmic pattern, not described so far, observed in the serum of a patient with a controversial diagnosis of systemic lupus erythematosus (SLE). Moreover,
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Simultaneous measurement of twenty-nine circulating cytokines and growth factors in female patients with overt autoimmune thyroid diseases. Autoimmunity (IF 2.125) Pub Date : 2020-04-25 Chao-Wen Cheng,Chung-Ze Wu,Kam-Tsun Tang,Wen-Fang Fang,Jiunn-Diann Lin
Cytokines and growth factors participate in immune responses, and the pathogenesis of autoimmune diseases. Herein, we simultaneously examined differential levels of 29 circulating factors to determine their associations in female patients with overt autoimmune thyroid disease (AITD). We enrolled 40 patients with Graves’ disease (GD), 20 patients with Hashimoto’s thyroiditis (HT), and 14 healthy controls
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Retroviruses in the pathogenesis of systemic lupus erythematosus: Are they potential therapeutic targets? Autoimmunity (IF 2.125) Pub Date : 2020-04-23 Rossella Talotta,Fabiola Atzeni,Magdalena Janina Laska
The pathogenesis of systemic lupus erythematosus (SLE) is characterised by the hyper-activation of immunologic pathways related to the antiviral response. Exogenous and endogenous retroviruses, by integrating their DNA templates in the host cell genome, may epigenetically control the transcription of genes involved in the immune response. Furthermore, their nucleic acids or neo-synthesized proteins
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MiR-153-3p induces immune dysregulation by inhibiting PELI1 expression in umbilical cord-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Autoimmunity (IF 2.125) Pub Date : 2020-04-23 Dan Li,Xiaoqing Li,Mingyue Duan,Yufeng Dou,Yuan Feng,Nan Nan,Wanggang Zhang
Mesenchymal stem cells (MSCs) are identified as a promising tool for the treatment of autoimmune diseases, and several microRNAs (miRNAs) are shown to exhibit vital roles in immune diseases. However, their function and mechanism in systemic lupus erythematosus (SLE) is still unclear. The qRT-PCR analysis was employed to investigate level of miR-153-3p. Subsequently, western blot and luciferase reporter
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Nanomedicine-mediated prevention of inflammatory monocytes infiltration ameliorate ovalbumin-induced allergic rhinitis in mouse model. Autoimmunity (IF 2.125) Pub Date : 2020-04-14 Xiaofeng Gu,Feng Xiao,Wenmin Lu,Ying Xu,Xia Li,Chenjie Yu,Xinyan Cui
Th2 immune cells infiltration into nasal mucosa is one of the characters of allergic rhinitis (AR). We aimed to explore whether inhibition of Th2 immune cells infiltration would attenuate AR progression. AR mouse model was established by i.p. injection of ovalbumin (OVA). The infiltrated immune cells into nasal lavage fluid were detected by flow cytometry. Cytokine concentration in serum was determined
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Assessing vitamin D levels in an anti-DFS70 positive population: New insights emerging. Autoimmunity (IF 2.125) Pub Date : 2020-03-13 Teresa Carbone,Vito Pafundi,Nicola Bizzaro,Maria Infantino,Maria Carmela Padula,Angela Anna Padula,Salvatore D'Angelo
Background: Anti-dense fine speckled 70 (DFS70) autoantibodies have more often been described in apparently healthy individuals than in patients with systemic autoimmune rheumatic diseases (SARD). The aim of this study was to explore the link between anti-DFS70 autoantibodies and vitamin D (25(OH)D) levels in an Italian adult cohort. Methods: Serum samples from 34 (five males and 29 females) anti-DFS70
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Abnormal expression of BAFF and its receptors in peripheral blood and skin lesions from systemic lupus erythematosus patients. Autoimmunity (IF 2.125) Pub Date : 2020-03-11 Yongjian Chen,Ming Yang,Di Long,Qianwen Li,Ming Zhao,Haijing Wu,Qianjin Lu
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by abnormal T and B cells. B-cell activating factor (BAFF) has been suggested to play a crucial role in lupus by promoting the proliferation, differentiation, and survival of B cells. Increased serum levels of BAFF have been found in patients with lupus. However, the expression of BAFF and its receptors on immune cells
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Serum IL-21 levels from celiac disease patients correlates with anti-tTG IgA autoantibodies and mucosal damage. Autoimmunity (IF 2.125) Pub Date : 2020-03-11 Erika Iervasi,Renata Auricchio,Antonella Strangio,Luigi Greco,Daniele Saverino
Objectives: Coeliac disease is a multifactorial disorder influenced by environmental, genetic and immunological factors. Interleukin (IL)-21 has been linked to an increase disease risk and the serum level of IL-21 seems to be increased in CD compared to a healthy control population. Methods: Sera were collected from 160 CD patients, 120 untreated and 40 following a gluten-free diet, and form 45 healthy
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CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer. Autoimmunity (IF 2.125) Pub Date : 2020-03-04 Shanping Shi,Shazhou Ye,Jianmei Mao,Yuqing Ru,Yicong Lu,Xiaoyue Wu,Mingjun Xu,Tingwei Zhu,Yibo Wang,Yuanming Chen,Xiaoli Tang,Yang Xi
Background: Chymase 1 (CMA1), a gene known to be expressed in mast cells (MCs), is largely linked to immunity. However, the relationship between CMA1 and prognosis of multiple tumours and tumour-infiltrating lymphocytes (TILs) remains elusive. Methods: The differential expressions of CMA1 in different tumours and their corresponding normal tissues were evaluated via exploring Tumour Immune Estimation
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Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. Autoimmunity (IF 2.125) Pub Date : 2020-02-24 Qing Luo,Lu Zhang,Le Fang,Biqi Fu,Yang Guo,Zikun Huang,Junming Li
Circular RNAs (circRNAs) are a class of non-coding RNAs that play a crucial role in diagnosis and prognosis of systemic lupus erythematosus (SLE). However, circRNAs expression profiling in SLE from different reports are different. In this study, 11 circRNAs (hsa_circ_0000479, hsa_circ_0002316, hsa_circ_0000317, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0087798, hsa_circ_0008529, hsa_circ_0000787
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DNA methylation changes on immune cells in Systemic Lupus Erythematosus. Autoimmunity (IF 2.125) Pub Date : 2020-02-04 Carolina Hurtado,Liliana Yazmín Acevedo Sáenz,Elsa María Vásquez Trespalacios,Rodrigo Urrego,Scott Jenks,Iñaki Sanz,Gloria Vásquez
DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. The present review compiles the
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Identification of key biomolecules in rheumatoid arthritis through the reconstruction of comprehensive disease-specific biological networks. Autoimmunity (IF 2.125) Pub Date : 2020-02-03 Betul Comertpay,Esra Gov
Rheumatoid arthritis (RA) frequently seen chronic synovial inflammation causing joint destruction, chronic disability and reduced life expectancy. The pathogenesis of RA is not completely known. In this study, several gene expression data including synovial tissue and macrophages from synovial tissues were integrated with a holistic perspective and the molecular targets and signatures in RA were determined
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IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study. Autoimmunity (IF 2.125) Pub Date : 2020-01-29 Isaura Isabelle Fonseca Gomes da Silva,Camilla Albertina Dantas Lima,Maria Larissa Andrade Monteiro,Daniella Alves Silva Pimentel Barboza,Eliezer Rushansky,Maria Helena Queiroz de Araújo Mariano,Paula Sandrin-Garcia,Paulo Roberto Eleutério de Souza,Maria de Mascena Diniz Maia
Rheumatoid arthritis (RA) is an autoimmune disease which can lead to progressive and functional disability. Literature data suggest that some inflammatory proteins are dysregulated in RA patients and its genetic polymorphisms may contribute to the aetiology and pathogenesis of disease in different ethnic groups. Polymorphisms in IL1β, IL18, NFKB1 and IFNG genes were studied in different populations
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Annexin-coated particles induce antigen-specific immunosuppression. Autoimmunity (IF 2.125) Pub Date : 2020-01-14 Corinna Link,Fatmire Bujupi,Peter H Krammer,Heiko Weyd
Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal on apoptotic cells which antagonises Toll-like receptor (TLR) signalling, we examined whether the tolerogenic capacity of Anx can be exploited to downregulate
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Human antimicrobial peptides in autoimmunity. Autoimmunity (IF 2.125) Pub Date : 2020-01-08 Ekaterina S Umnyakova,Maria S Zharkova,Mikhail N Berlov,Olga V Shamova,Vladimir N Kokryakov
Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously,
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Therapeutic effect of mesenchymal stem cell on Hashimoto's thyroiditis in a rat model by modulating Th17/Treg cell balance. Autoimmunity (IF 2.125) Pub Date : 2019-12-03 Yongjun Cao,Xiaowen Jin,Yumeng Sun,Weibo Wen
The autoimmune condition Hashimoto's thyroiditis (HT) is a disease wherein lymphocytes mediate the autoimmune damage and destruction of the thyroid gland. There are currently no effective means of treating HT, with the primary strategies of thyroid hormone therapy, surgery, or immunomodulatory therapy being associated with serious risks and side effects. There is thus a clear and urgent need to identify
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Lower proportion of CD19+IL-10+ and CD19+CD24+CD27+ but not CD1d+CD5+CD19+CD24+CD27+ IL-10+ B cells in children with autoimmune thyroid diseases. Autoimmunity (IF 2.125) Pub Date : 2019-12-02 Karolina Stożek,Kamil Grubczak,Viviana Marolda,Andrzej Eljaszewicz,Marcin Moniuszko,Artur Bossowski
Introduction: As it is generally known, regulatory B cells (Bregs) control inflammation and autoimmunity. The significance of Bregs in the population of children with autoimmune thyroid diseases (AITD) still offers plenty of potential to explore. The aim of this study was to estimate the expression of Bregs (phenotype CD19+CD24+CD27+IL-10+, CD19+IL-10+, CD1d+CD5+CD19+IL-10+ and CD1d+CD5+CD19+CD24+CD27+)
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Effect of high mobility group box 1 on Toll-like receptor 9 in B cells in myeloperoxidase-ANCA-associated vasculitis. Autoimmunity (IF 2.125) Pub Date : 2019-12-02 Chen Wang,Hui Deng,Yan Gong,Ran You,Min Chen,Ming-Hui Zhao
High mobility group box 1 (HMGB1) played pathogenic role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Recent findings demonstrated that Toll-like receptor 9 (TLR9) was involved in B cell tolerance breaking of autoimmune disease, including AAV. Here, we investigated the effect of HMGB1 on TLR9 in B cells of AAV. In the present work, patients with myeloperoxidase (MPO)-AAV
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Diagnostic performance of aPS/PT antibodies in neuropsychiatric lupus and cardiovascular complications of systemic lupus erythematosus. Autoimmunity (IF 2.125) Pub Date : 2019-11-29 Giuseppe A Ramirez,Valentina Canti,Stefania Del Rosso,Roberta Erra,Lucia Moiola,Marco Magnoni,Enrica P Bozzolo,Angelo A Manfredi,Patrizia Rovere-Querini
Background: Systemic lupus erythematosus (SLE) is associated with a constellation of complications affecting multiple organs, including neuropsychiatric manifestations (NPSLE) and ischaemic events, leading to increased long-term morbidity. Antiphospholipid antibodies (aPL) are a major determinant of vascular inflammation and thromboembolic risk. The diagnostic role of anti-phosphatidylserine/prothrombin
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Th1, Th2, and Th17 cytokines in systemic lupus erythematosus. Autoimmunity (IF 2.125) Pub Date : 2019-11-27 Farhana Muhammad Yusoff,Kah Keng Wong,Norhanani Mohd Redzwan
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the breakdown of immune tolerance leading to excessive inflammation and tissue damage. Imbalance in the levels of cytokines represents one of the multifactorial causes of SLE pathogenesis and it contributes to disease severity. Deregulated levels of T helper type 1 (Th1), type 2 (Th2), and type 17 (Th17) cytokines have been
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Association study between X-linked susceptibility genes and clinical features in Chinese female patients with systemic lupus erythematosus. Autoimmunity (IF 2.125) Pub Date : 2019-11-11 Shen Li,Dongsheng Di,Xiaoxiao Wu,Linlin Zhang,Ruishan Liu,Qian Huang,Haifeng Pan,Dongqing Ye,Ruixue Leng
Recent large-scale genetic association studies have identified that several single nucleotide polymorphisms (SNPs) on X chromosome are correlated with risk of systemic lupus erythematosus (SLE) in Chinese population. The aim of this study was to estimate association between these loci and clinical features in female patients with SLE. Six SNPs identified in previous studies were genotyped. Odds ratio
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Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren's syndrome. Autoimmunity (IF 2.125) Pub Date : 2019-10-30 Kathrine Skarstein,Janicke Liaaen Jensen,Hilde Galtung,Roland Jonsson,Karl Brokstad,Lara A Aqrawi
Salivary and lacrimal gland involvement is a characteristic feature of primary Sjögren's syndrome (pSS), where tissue destruction is mediated by mononuclear cell infiltration, resulting in lacrimal and salivary gland impairment. We have previously shown distinct prevalence of adipose tissue replacement in the minor salivary gland tissue from pSS patients. The salivary gland microenvironment was further
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Gene-gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population. Autoimmunity (IF 2.125) Pub Date : 2019-10-26 Rui Liu,Xu Zhang,Guangming Jiang,Yubo Ma,Jiajia Yang,Meng Wu,Renfang Han,Mengya Chen,Yaping Yuan,Xingxing Hu,Meijuan Pan,Shengqian Xu,Jianhua Xu,Zongwen Shuai,Yanfeng Zou,Guixia Pan,Faming Pan
Objectives: To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in the Chinese population.Methods: Six single-nucleotide polymorphisms (SNPs) in DKK1, LRP5, LRP6, and SOST genes were genotyped in 673 AS patients and 687 healthy controls by using SNPs can Technic. Single marker genetic association analysis was performed. Haplotypes were constructed
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Bisphenol A modified DNA: A possible immunogenic stimulus for anti-DNA autoantibodies in systemic lupus erythematosus. Autoimmunity (IF 2.125) Pub Date : 2019-10-26 Homaidan T Alhomaidan,Naila Rasheed,Salem Almatrafi,Fahad H Al-Rashdi,Zafar Rasheed
Anti-DNA antibodies are now considered as a universal diagnostic feature for the patients with systemic lupus erythematosus (SLE) but the mechanism(s) involved in the generation of these autoantibodies remains to be investigated. Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacturing of polycarbonated plastics. Upon mixing in the diet, it causes several health hazards. This study
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Diagnostic value of 18-F fluorodeoxyglucose PET/CT and bone scan in Schnitzler syndrome. Autoimmunity (IF 2.125) Pub Date : 2019-10-24 L Alix,A Néel,B Cador,A Smail,J Serratrice,F Closs-Prophette,P Jego,A Devillers,O Decaux
Introduction: Schnitzler syndrome is an auto-inflammatory disease defined by chronic urticarial eruption and monoclonal gammopathy. 18F fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is often performed, but its utility in Schnitzler syndrome has not been specifically investigated. The aim of this study was to determine whether PET/CT is informative in the diagnosis and
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Long non coding RNA H19: An emerging therapeutic target in fibrosing diseases. Autoimmunity (IF 2.125) Pub Date : 2019-10-24 Juan Li,Long-Ting Cao,Hong-Hui Liu,Xiao-Dong Yin,Jing Wang
Fibrosis is characterised by excessive deposition of the extracellular matrix (ECM) and develops because of fibroblast differentiation during the process of inflammation. There are few effective treatment options for this diseases due to the aetiology of fibrosis is not completely clarified. Long non-coding RNAs (lncRNAs), a type of ncRNA with a length of greater than 200 nucleotides without evident