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Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells J. Inflamm. (IF 2.8) Pub Date : 2021-01-07 Keizo Kohno; Satomi Koya-Miyata; Akira Harashima; Takahiko Tsukuda; Masataka Katakami; Toshio Ariyasu; Shimpei Ushio; Kanso Iwaki
NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regeneration phase. NK-4 treatment of THP-1 macrophages induced morphological features characteristic
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Dexamethasone can attenuate the pulmonary inflammatory response via regulation of the lncH19/miR-324-3p cascade J. Inflamm. (IF 2.8) Pub Date : 2021-01-07 Ye Chen; Chao Zhang; Chang-xue Xiao; Xiao-dong Li; Zhi-li Hu; Shou-di He; Xiao-jun Xiao; Feng Xu
To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment. IL-1β (10 ng/mL) and LPS (1 μg/mL) was used to construct inflammatory cell models with A549 cells; IL-1β performed better against LPS. Different concentrations of Dex were used to attenuate the inflammation induced by IL-1β, and its effect was assessed via RT-PCR to detect inflammatory
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Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity J. Inflamm. (IF 2.8) Pub Date : 2020-11-07 Fang Cui; Jing Guo; Hao-Fei Hu; Yi Zhang; Min Shi
Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may ameliorate the abnormal iron metabolism in obesity. This study was aimed to investigate the effect
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PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population J. Inflamm. (IF 2.8) Pub Date : 2020-10-31 Karina Vargas-Sánchez; Laura Vargas; Yenny Urrutia; Iván Beltrán; Ana Beatriz Rossi; Hernán Yupanqui Lozano; Jorge Guarín; Monica Losada-Barragán
Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Peroxisome proliferator-activated receptors (PPARs) are a group of transcription factors essential
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Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury J. Inflamm. (IF 2.8) Pub Date : 2020-10-30 James G. Macfarlane; David A. Dorward; Marie-Hélène Ruchaud-Sparagano; Jonathan Scott; Christopher D. Lucas; Adriano G. Rossi; A. John Simpson
Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functions, including adhesion-dependent degranulation, are controlled by src family kinases. Dasatinib is a potent src inhibitor used in treating patients with chronic myeloid leukaemia and treatment-resistant
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Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm J. Inflamm. (IF 2.8) Pub Date : 2020-10-29 Mozhgan Jahani; Sadat Dokaneheifard; Kamran Mansouri
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and results in lung pneumonia following acute respiratory distress syndrome (ARDS) and patient’s death in severe cases. ARDS is a severe form of acute lung injury that is caused by high inflammatory
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Association of intestinal and systemic inflammatory biomarkers with immune reconstitution in HIV+ patients on ART J. Inflamm. (IF 2.8) Pub Date : 2020-10-15 Mariana del Rocio Ruiz-Briseño; Judith Carolina De Arcos-Jiménez; Sarah Ratkovich-González; Karina Sánchez-Reyes; Luz A. González-Hernández; Jaime F. Andrade-Villanueva; Monserrat Alvarez-Zavala
HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatment, these alterations in HIV+ patients reach similar levels to HIV- controls. However, almost 20% patients have deficient immune reconstitution of CD4+ T-cells, which make them more susceptible
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LncRNA THRIL is upregulated in sepsis and sponges miR-19a to upregulate TNF-α in human bronchial epithelial cells. J. Inflamm. (IF 2.8) Pub Date : 2020-09-10 Tao Liu,Jingbin Liu,Chunhua Tian,Hongyuan Wang,Min Wen,Mingyu Yan
Long non-coding RNAs (lncRNAs) have been demonstrated to play critical roles in various diseases. Our bioinformatics analysis showed that lncRNA TNFα and heterogenous nuclear ribonucleoprotein L (hnRNPL) related immunoregulatory LincRNA (THRIL) may interact with miR-19a, which targets TNF-α. This study aimed to explore the role of THRIL, an enhancer of LPS-induced inflammatory, in sepsis. Research
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Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF-κB pathway. J. Inflamm. (IF 2.8) Pub Date : 2020-08-28 Shi-Jian Yi,Yang Wu,Lan-Lan Li,Qian-Kun Liang,Yue Xiao
Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the therapeutic approach to TC, but the effects are significantly inhibited by coagulopathy. To identify the therapeutic effects and underlying mechanism of compound amino acid (CAA) combined with high-dosage
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Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis. J. Inflamm. (IF 2.8) Pub Date : 2020-08-24 Pedro A Ruiz Castro,Ulrike Kogel,Giuseppe Lo Sasso,Blaine W Phillips,Alain Sewer,Bjorn Titz,Llenalia Garcia,Athanasios Kondylis,Emmanuel Guedj,Dariusz Peric,David Bornand,Remi Dulize,Celine Merg,Maica Corciulo,Nikolai V Ivanov,Manuel C Peitsch,Julia Hoeng
Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and including two main disease manifestations: ulcerative colitis (UC) and Crohn’s disease. In the last few decades, naturally occurring alkaloids have gained interest because of their substantial anti-inflammatory
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Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women. J. Inflamm. (IF 2.8) Pub Date : 2020-08-12 Sofie Jacobson,Peter Larsson,Anna-Maja Åberg,Göran Johansson,Ola Winsö,Stefan Söderberg
Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL deficiency leads to increased susceptibility to infections or not. The aim of this study was to determine if low levels of mannose-binding lectin (MBL) predict sepsis development, sepsis severity
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Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest. J. Inflamm. (IF 2.8) Pub Date : 2020-08-12 Ludmila Khailova,Justin Robison,James Jaggers,Richard Ing,Scott Lawson,Amy Treece,Danielle Soranno,Suzanne Osorio Lujan,Jesse A Davidson
Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion represents a novel therapy for post-cardiac surgery organ injury. However, the effects of cardiopulmonary bypass and bovine-intestinal alkaline phosphatase infusion on tissue-level alkaline phosphatase
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Emodin alleviates LPS-induced inflammatory response in lung injury rat by affecting the function of granulocytes. J. Inflamm. (IF 2.8) Pub Date : 2020-08-08 Hongxia Mei,Ying Tao,Tianhao Zhang,Feng Qi
Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are critical life-threatening syndromes characterized by the infiltration of a large number of granulocytes (mainly neutrophils) that lead to an excessive inflammatory response. Emodin (Emo) is a naturally occurring anthraquinone derivative and an active ingredient of Chinese medicine. It is believed to have anti-inflammatory
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N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis. J. Inflamm. (IF 2.8) Pub Date : 2020-08-05 Fenglian He,Guanghui Zheng,Jingying Hou,Qiaohua Hu,Qin Ling,Gongfa Wu,Hui Zhao,Jin Yang,Yue Wang,Longyuan Jiang,Wanchun Tang,Zhengfei Yang
NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactive oxygen species (ROS) in the sterile inflammatory response triggered by ischemia/reperfusion (I/R) injury. N-acetylcysteine (NAC) is an antioxidant and plays a protective role in local myocardial
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Offspring sex affects the susceptibility to maternal smoking-induced lung inflammation and the effect of maternal antioxidant supplementation in mice. J. Inflamm. (IF 2.8) Pub Date : 2020-08-05 Baoming Wang,Yik Lung Chan,Shengyu Zhou,Sonia Saad,Hui Chen,Brian G Oliver
Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce the adverse impacts of maternal SE on renal and brain disorders in offspring. Here, we investigated the effect of maternal L-Carnitine supplementation on lung inflammatory pathways, autophagy
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Potential interaction between lysophosphatidic acid and tumor-associated macrophages in ovarian carcinoma. J. Inflamm. (IF 2.8) Pub Date : 2020-08-05 Ying Feng,Meizhu Xiao,Zihan Zhang,Ran Cui,Xuan Jiang,Shuzhen Wang,Huimin Bai,Chongdong Liu,Zhenyu Zhang
Ovarian carcinoma is the deadliest type of gynecological cancer. The unique tumor microenvironment enables specific and efficient metastasis, weakens immunological monitoring, and mediates drug resistance. Tumor associated macrophages (TAMs) are a crucial part of the TME and are involved in various aspects of tumor behavior. Lysophosphatidic acid (LPA) is elevated in the blood of ovarian carcinoma
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NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-κB/COX-2/PG pathway. J. Inflamm. (IF 2.8) Pub Date : 2020-06-24 Biao Tang,Dan Liu,Lingyu Chen,Yu Liu
Primary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activation and PD is still unclear. To investigate the potential role of NLRP3 inflammasome activation in the pathogenesis of PD, 30 female Kunming mice without pregnancy were used for experiments. The
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SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping. J. Inflamm. (IF 2.8) Pub Date : 2020-06-10 Gagandeep Kaur,Giuseppe Lungarella,Irfan Rahman
The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that old age and pre-existing disease conditions (hypertension and diabetes) result in severe disease outcome and mortality amongst COVID-19 patients. Evidences suggest that the S1 domain of the SARS-CoV-2
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A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis. J. Inflamm. (IF 2.8) Pub Date : 2020-05-29 Sae-Bom Yoon,Chang Hoon Lee,Hyun Young Kim,Daeyoung Jeong,Moon Kook Jeon,Sun-A Cho,Kwangmi Kim,Taeho Lee,Jung Yoon Yang,Young-Dae Gong,Heeyeong Cho
Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseases threatening public health. Sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) act as pro-inflammatory mediators, as an angiogenesis factor and a mitogen in skin fibroblasts
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Efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia, a multicenter, randomized, double-blind, placebo-controlled trial. J. Inflamm. (IF 2.8) Pub Date : 2020-05-14 Rongmeng Jiang,Bing Han,Meihua Song,Bing Xue,Yongxiang Zhang,Yanyan Ding,Jin Chen,Jing Zhu,Jianhua Liu,Qingrong Nie,Xuefeng Han,Xiuhong Jin,Xiaoyin Shan,Weian Guo,Erming Zhang,Zuoqing Zhang,Changhong Zhang,Jie Zhang,Baozeng Wang,Shuwen Dong,Jiandong Li,Xiaoguang Li,Xingwang Li
Background To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia. Methods One hundred sixty-four patients with noninfluenza viral pneumonia were divided into IFNα1b and control groups. The IFNα1b group received routine treatment + aerosol inhalation of recombinant human IFNα1b injection (50 μg × 2 injections
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Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine. J. Inflamm. (IF 2.8) Pub Date : 2020-05-01 Gang Lv,Guanhua Zhu,Maohua Xu,Xingping Gao,Qingfeng Xiao
Background Dexmedetomidine (Dex) is a highly selective agonist of the α2 adrenergic receptor and a common sedative; however, its anti-inflammatory effect has been studied. In this study, the inhibitory effect of Dex on inflammation in dental pulp cells was assessed. For this, the effect of Dex on inflammation induced by carrageenan (Car) in human dental pulp cells (hDPCs) was evaluated. Car incubation
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MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model. J. Inflamm. (IF 2.8) Pub Date : 2020-04-25 Gaohai Shao,Changlong Zhou,Kunlong Ma,Wang Zhao,Qijiang Xiong,Ling Yang,Zhongyan Huang,Zhao Yang
Background Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization following intracerebral hemorrhage (ICH) has not been well studied. Methods In the experiment, macrophages were administered with erythrocyte lysates, and then miR-494-, Nrdp1-, and M1/M2-related
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Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model. J. Inflamm. (IF 2.8) Pub Date : 2020-04-21 Hai B Tran,Matthew G Macowan,Adrian Abdo,Martin Donnelley,David Parsons,Sandra Hodge
Background Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enhances NLRP3 inflammasome activation and dysregulated S1P signalling. Methods Lung tissues from mice overexpressing the beta-unit of the epithelial sodium channel (βENaC) and their littermate
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Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies. J. Inflamm. (IF 2.8) Pub Date : 2020-04-21 Amandip Kaur,Paraskevi Goggolidou
Dynamic interactions between the gastrointestinal epithelium and the mucosal immune system normally contribute to ensuring intestinal homeostasis and optimal immunosurveillance, but destabilisation of these interactions in genetically predisposed individuals can lead to the development of chronic inflammatory diseases. Ulcerative colitis is one of the main types of inflammatory diseases that affect
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Elevated soluble TNFα levels and upregulated TNFα mRNA expression in purified peripheral blood monocyte subsets associated with high-grade hepatocellular carcinoma J. Inflamm. (IF 2.8) Pub Date : 2020-03-30 C. Martín-Sierra; R. Martins; M. Coucelo; A. M. Abrantes; R. C. Oliveira; J. G. Tralhão; M. F. Botelho; E. Furtado; M. R. Domingues; A. Paiva; P. Laranjeira
Chronic inflammation is involved in the initiation and progression of various cancers, including liver cancer. The current study focuses on the characterization of the peripheral immune response in hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) patients, before and after surgical procedure, in order to assess the effect of tumor resection in the immune system homeostasis and to determine
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Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes J. Inflamm. (IF 2.8) Pub Date : 2020-03-24 Sheng-long Ding; Zhi-ying Pang; Xue-mei Chen; Zheng Li; Xin-xin Liu; Qi-lin Zhai; Jun-ming Huang; Zhi-yong Ruan
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties in several chronic diseases. However, the effects of UA on OA remain unclear. The aim of the current study was to investigate
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The role of SOCS3 in the hypothalamic paraventricular nucleus in rat model of inflammatory pain. J. Inflamm. (IF 2.8) Pub Date : 2020-02-27 Na Meng,Ning-Ning Ji,Ziming Zhou,Yicheng Qian,Yu Tang,Kangbo Yang,Binbin Chen,Yong-Mei Zhang
Background Inflammatory molecular signals are modulated by a variety of intracellular transduction pathways, the activation of which may induce and amplify the spread of inflammatory response. Suppresser of cytokine signaling 3 (SOCS3) is an established negative feedback regulation transcription factor associated with tumor, diabetes mellitus, inflammation and anaphylaxis. Herein, we investigated whether
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Prediction and identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from endocan. J. Inflamm. (IF 2.8) Pub Date : 2020-02-19 Gaohai Shao,Qingjun Liu,Ling Yang,Guibo Feng,Wang Zhao,Zhongyan Huang,Zhao Yang
Background Prediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development of tumor immunotherapy strategy. Endocan has been identified as antigen overexpressed in various tumors. Methods In this experiment, we predicted and identified HLA-A2-restricted CTL epitopes from endocan by using the following procedures. Firstly, we
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Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression. J. Inflamm. (IF 2.8) Pub Date : 2020-02-18 Wei Zhang,Chi Zhang,Chengfang Hu,Congfeng Luo,Biao Zhong,Xiaowei Yu
Background The antisense cerebellar degenerative-related protein-1 (CDR1as) has been identified as a sponge for several microRNAs. MiR-641 has been shown to be downregulated in osteoarthritic human chondrocytes, but its regulation and function in osteoarthritis (OA) has not been reported. Methods OA cartilage samples were obtained from the knee joints of 12 patients (8 males and 4 females at age of
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Low-intensity ultrasound attenuates paw edema formation and decreases vascular permeability induced by carrageenan injection in rats. J. Inflamm. (IF 2.8) Pub Date : 2020-02-13 Kil Hwan Kim,Hyeon-Woo Im,Mrigendra Bir Karmacharya,Sejong Kim,Byoung-Hyun Min,So Ra Park,Byung Hyune Choi
Background Therapeutic potential of low-intensity ultrasound (LIUS) has become evident in various musculoskeletal diseases. We have previously shown that LIUS has an inhibitory effect on local edema in various diseases including the arthritis and brain injury. In this study, we examined whether LIUS can attenuate paw edema formation vis-à-vis vascular permeability and inflammation in rats induced by
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Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis. J. Inflamm. (IF 2.8) Pub Date : 2020-02-11 Mehdi Hassanpour,Fateme Hajihassani,Amirataollah Hiradfar,Nasser Aghamohammadzadeh,Reza Rahbarghazi,Nasser Safaie,Mohammad Nouri,Yunes Panahi
The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination in Multiple sclerosis (MS). These features cause the nervous system dysfunction. The follow-up of molecular alterations could give us a real-state vision about intracellular status during pathological
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Different signaling pathways involved in the anti-inflammatory effects of unfractionated heparin on lipopolysaccharide-stimulated human endothelial cells. J. Inflamm. (IF 2.8) Pub Date : 2020-02-10 Xu Li,Lu Li,Yuequan Shi,Sihan Yu,Xiaochun Ma
Background There is a complex interplay between inflammatory response and coagulation in sepsis. Heparin is used as a recognized anticoagulant and possesses multiple biological properties that possibly affect sepsis. This study aimed to determine the possible signaling pathways involved in the anti-inflammatory effects of unfractionated heparin (UFH) on lipopolysaccharide (LPS)-stimulated human pulmonary
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Acupoint application inhibits nerve growth factor and attenuates allergic inflammation in allergic rhinitis model rats. J. Inflamm. (IF 2.8) Pub Date : 2020-02-10 Wenzhan Tu,Xiaolong Chen,Qiaoyun Wu,Xinwang Ying,Rong He,Xinfa Lou,Guanhu Yang,Kecheng Zhou,Songhe Jiang
Background Acupoint application therapy (AAT) has been widely used to treat allergic inflammation induced by allergic rhinitis (AR). The therapeutic effect of acupoint application is obvious. But the underlying therapeutic mechanism is still indistinct. Nerve growth factor (NGF) expression showed a dramatic rise in nasal mucosa tissue after AR, and allergic inflammation also increased significantly
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Dendritic cells transduced with glioma-expressed antigen 2 recombinant adenovirus induces specific cytotoxic lymphocyte response and anti-tumor effect in mice. J. Inflamm. (IF 2.8) Pub Date : 2020-01-31 Gaohai Shao,Changlong Zhou,Kunlong Ma,Wang Zhao,Guibo Feng,Qijiang Xiong,Ling Yang,Zhao Yang
Introduction Glioma is an aggressive common cancer with high mortality worldwide. Up to date, the effective medical therapeutical strategy is limited. Numerous previous studies have indicated that glioma-expressed antigen 2 (GLEA2) might be an attractive prognostic glioma biomarker. Methods In this experiment, dendritic cells (DCs) transduced with GLEA2 recombinant adenovirus were utilized to generate
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Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome J. Inflamm. (IF 2.8) Pub Date : 2020-01-06 Guang-chun Wang; Tian-run Huang; Yang-yang Hu; Ke-yi Wang; Heng Shi; Lei Yin; Bo Peng
The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was to investigate the corpus cavernosum smooth muscle cell function and phenotype transformation in Experimental autoimmune prostatitis (EAP) rats. EAP was induced in rats by using prostate protein
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Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgia J. Inflamm. (IF 2.8) Pub Date : 2020-01-03 Mu Xu; Yi Yan; Mengye Zhu; Zhijian Wang; Xuexue Zhang; Daying Zhang
This study aims to investigate the role of long non-coding RNA Gm14461 in regulating pain transmission in trigeminal neuralgia (TN). The mouse TN model was produced by chronic constriction injury of the infraorbital nerve (CCI-ION). The values of mechanical withdrawal threshold (MWT) were measured to assess the nociception of mice at different times after CCI-ION surgery (0, 1, 3, 5, 7, 9, 11, 13,
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Nerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells J. Inflamm. (IF 2.8) Pub Date : 2019-12-26 Huiyu Chen; Jing Zhang; Yiqin Dai; Jianjiang Xu
In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pluripotent neurotrophic factor with immune regulatory effect, was proved to be effective in Herpes simplex keratitis (HSK) treatment, although the detailed mechanisms remain unclear. This study
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Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis J. Inflamm. (IF 2.8) Pub Date : 2019-12-23 Elham Shahriyari; Leila Vahedi; Nasrin Roshanipour; Mohammad Asghari Jafarabadi; Amin Khamaneh; Maryam Ghaffari Laleh
Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD. A systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications
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The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE−/− mice J. Inflamm. (IF 2.8) Pub Date : 2019-12-16 Miguel Hueso; Angela Casas; Adrian Mallén; Laura de Ramón; Nuria Bolaños; Cristian Varela; Josep M. Cruzado; Joan Torras; Estanislao Navarro
Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosclerosis (ATH) progression. Here, we have deepened on the effects of the siCD40 treatment by evaluating retrospectively, in stored kidneys from
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Nrdp1 increases neuron apoptosis via downregulation of Bruce following intracerebral haemorrhage. J. Inflamm. (IF 2.8) Pub Date : 2019-12-09 Changlong Zhou,Qingjun Liu,Wang Zhao,Ling Yang,Zhongyan Huang,Zhao Yang
Background Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that plays an important role in regulating cell growth, apoptosis and oxidative stress. However, the data regarding its expression and exact mechanism in neuronal injury following ICH has not been well identified. Methods In this study, primary cortical neurons from C57BL/6 mice were subjected to erythrocyte lysates
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LncRNA H19 induced by helicobacter pylori infection promotes gastric cancer cell growth via enhancing NF-κB-induced inflammation. J. Inflamm. (IF 2.8) Pub Date : 2019-11-26 Yifeng Zhang,Jin Yan,Chao Li,Xiaoyong Wang,Yu Dong,Xiaoran Shen,Ximei Zhang
Background The aim of this study was to investigate the role of long non-coding RNA (lncRNA) H19 in gastric cancer (GC) with Helicobacter pylori (H. pylori). Methods H19 expression in peripheral blood from H. pylori+/- GC patients and healthy donors (control) as well as in GC tissues and cells were detected by qRT-PCR. Cell proliferation was evaluated by CCK-8 assay. Cell migration and invasion were
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Mesangial cells are key contributors to the fibrotic damage seen in the lupus nephritis glomerulus J. Inflamm. (IF 2.8) Pub Date : 2019-11-14 Rachael D. Wright; Paraskevi Dimou; Sarah J. Northey; Michael W. Beresford
Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients. Mesangial cells (MCs) comprise a third of the glomerular cells and are key contributors to fibrotic changes within the kidney. This project aims to identify the roles of MCs in an in vitro model of LN. Conditionally immortalised MCs were treated with pro-inflammatory cytokines or with patient sera in an
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Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway. J. Inflamm. (IF 2.8) Pub Date : 2019-10-11 Li Wang,Linjie Feng,Jingyu Zhang
Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different
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Structural and functional abnormalities of penile cavernous endothelial cells result in erectile dysfunction at experimental autoimmune prostatitis rat. J. Inflamm. (IF 2.8) Pub Date : 2019-07-25 Tianrun Huang,Guangchun Wang,Yangyang Hu,Heng Shi,Keyi Wang,Lei Yin,Bo Peng
Background There is growing recognition of the association of CP/CPPS accompany with ED. However, the specific mechanism of action remains unclear. The aim of this study was to investigate structural and functional abnormalities of cavernous endothelial cells in EAP rat, which may result in the ED. Methods we use rat prostate protein extract supplemented with immunoadjuvant to induce EAP rat, ICP and
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IL-35 alleviates inflammation progression in a rat model of diabetic neuropathic pain via inhibition of JNK signaling. J. Inflamm. (IF 2.8) Pub Date : 2019-07-23 Yinghai Jiang,Jing Wang,Haiqin Li,Lingjie Xia
Background Emerging evidence has demonstrated that inflammation is involved in the occurrence and development of diabetic neuropathic pain (DNP). The anti-inflammatory property of interleukin (IL)-35 makes it a promising candidate to block the pain perception. The present study was undertaken to investigate whether IL-35 could attenuate DNP in streptozotocin (STZ)-induced rat model and its potential
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The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity. J. Inflamm. (IF 2.8) Pub Date : 2019-07-15 Paulo R Z Antas,Carlos G G Ponte,Matheus R Almeida,Lawrence H P Albuquerque,Periela S Sousa-Vasconcelos,Thaíze Pedro,Natália L S Gomes,Otacílio C Moreira,Fernanda C Silva,Luíz R R Castello-Branco,Rosa T Pinho
Background Caused by Mycobacterium tuberculosis, tuberculosis (TB) is an extremely contagious disease predominantly affecting the lungs. TB is found worldwide and has a major impact on public health safety primarily due to its high mortality rate. Applied for over a hundred years as a preventive measure, Mycobacterium bovis BCG remains the only available TB vaccine. Only one seminal study about the
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Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle. J. Inflamm. (IF 2.8) Pub Date : 2019-07-04 Chu-Sook Kim,Yeonsoo Joe,Hye-Seon Choi,Sung Hoon Back,Jeong Woo Park,Hun Taeg Chung,Eun Roh,Min-Seon Kim,Tae Youl Ha,Rina Yu
Background Obesity-induced skeletal muscle inflammation is a major contributor of skeletal muscle loss/atrophy and is implicated in metabolic complications such as insulin resistance. Fibroblast growth factor 21 (FGF21) is known to be an important metabolic regulator with anti-inflammatory properties. However, the effect of FGF21 on skeletal muscle atrophy is unclear. In this study, we investigated
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Hypertonic solution-induced preconditioning reduces inflammation and mortality rate. J. Inflamm. (IF 2.8) Pub Date : 2019-07-03 Rosangela Nascimento Pimentel,Ricardo Costa Petroni,Hermes Vieira Barbeiro,Denise Frediani Barbeiro,Mariana Macedo Andrade,Suely Kumini Ariga,Francisco Garcia Soriano
Background Dysregulated inflammatory response is common cause of organ damage in critical care patients. Preconditioning/tolerance is a strategy to prevent exacerbated inflammation. The aim of this study is to analyze hypertonic saline 7.5% as a potential inducer of preconditioning that protect from a lethal dose of LPS and modulates systemic inflammatory profile in mice. Methods Male Balb/C mice received
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"In sickness and in health" - how neutrophil extracellular trap (NET) works in infections, selected diseases and pregnancy. J. Inflamm. (IF 2.8) Pub Date : 2019-06-28 Paulina Niedźwiedzka-Rystwej,Weronika Repka,Beata Tokarz-Deptuła,Wiesław Deptuła
The discovery of the NET network (neutrophil extracellular trap) has revolutionized the perception of defense mechanisms used by neutrophils in infections and non-infectious states, as this mechanism proves the complexity of the ways in which neutrophils can act in the organism. The paper describes the NET network and its participation in bacterial, viral, fungal and parasitic infections, both in a
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High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats. J. Inflamm. (IF 2.8) Pub Date : 2019-06-25 Thea Laurentius,Ute Raffetseder,Claudia Fellner,Robert Kob,Mahtab Nourbakhsh,Jürgen Floege,Thomas Bertsch,Leo Cornelius Bollheimer,Tammo Ostendorf
Background Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was to examine the inflammatory status of the kidneys and potential ongoing renal damage, i.e., tubular damage and fibrosis after long-term obesity maintained through persistent consumption
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The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis. J. Inflamm. (IF 2.8) Pub Date : 2019-06-06 Qihong Que,Xinghua Guo,Longxin Zhan,Shaodong Chen,Zengli Zhang,Xiaoming Ni,Bin Ye,Shuanglin Wan
Background Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for the treatment of OA. Notably, glucagon-like peptide-1 (GLP-1)-based drugs are being successfully used to control glucose levels in patients with diabetes mellitus. In addition, recent
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Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice. J. Inflamm. (IF 2.8) Pub Date : 2019-05-29 Jordan R Yaron,Hao Chen,Sriram Ambadapadi,Liqiang Zhang,Amanda M Tafoya,Barbara H Munk,Dara N Wakefield,Jorge Fuentes,Bruno J Marques,Krishna Harripersaud,Mee Yong Bartee,Jennifer A Davids,Donghang Zheng,Kenneth Rand,Lisa Dixon,Richard W Moyer,William L Clapp,Alexandra R Lucas
Background Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem after vessel occlusion and infarction or during harvest and surgery in transplants. After transplant, liver IRI (LIRI) contributes to increased acute and chronic rejection and graft
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Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1. J. Inflamm. (IF 2.8) Pub Date : 2019-05-29 Xuan Li,Lijie Duan,Sujuan Yuan,Xibing Zhuang,Tiankui Qiao,Jian He
Background Radiation-induced lung fibrosis (RILF) is a severe and life-threatening complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a form programmed cell death implicated in the pathologies of inflammation. This study aimed to investigate the role of ferroptosis in RILF, and the effectiveness and the potential underlying mechanism of ferroptosis inhibitor
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Evidence for the important role of inflammation in xenotransplantation. J. Inflamm. (IF 2.8) Pub Date : 2019-05-28 Juan Li,Hidetaka Hara,Yi Wang,Charles Esmon,David K C Cooper,Hayato Iwase
There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). Increases in inflammatory markers, e.g., C-reactive protein, histones, serum amyloid A, D-dimer, cytokines, chemokines, and a decrease in free triiodothyronine, have been demonstrated in the recipient
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Anti-vascular endothelial growth factor agent reduces inflammation in macular edema with central retinal vein occlusion. J. Inflamm. (IF 2.8) Pub Date : 2019-05-22 Asako Mashima,Hidetaka Noma,Kanako Yasuda,Hiroshi Goto,Masahiko Shimura
Background Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were investigated in patients with central retinal vein occlusion (CRVO) and macular edema who received intravitreal ranibizumab injection (IRI) and were followed for 6 months. Methods Aqueous
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Role of autophagy in atherosclerosis: foe or friend? J. Inflamm. (IF 2.8) Pub Date : 2019-05-02 Mehdi Hassanpour,Reza Rahbarghazi,Mohammad Nouri,Nasser Aghamohammadzadeh,Nasser Safaei,Mahdi Ahmadi
Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detection of cell compensatory mechanisms against atherosclerotic changes to restore cell
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Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease. J. Inflamm. (IF 2.8) Pub Date : 2019-04-02 Cheng-Maw Ho,Shu-Li Ho,Yung-Ming Jeng,Yu-Sheng Lai,Ya-Hui Chen,Shao-Chun Lu,Hui-Ling Chen,Po-Yuan Chang,Rey-Heng Hu,Po-Huang Lee
Background Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of free cholesterol in macrophages leading to activation of NLRP3 inflammasome and production of interleukin-1β (IL-1β) has been linked to atherosclerosis-associated inflammation. However
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SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome. J. Inflamm. (IF 2.8) Pub Date : 2019-03-18 Hadas Ben-Eli,Nir Gomel,Doron Jacob Aframian,Rania Abu-Seir,Riki Perlman,Eldad Ben-Chetrit,Dror Mevorach,Geffen Kleinstern,Ora Paltiel,Abraham Solomon
Background Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren's syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine levels among SS and DES patients in Israel. Methods We recruited 180 subjects, 82 with SS and 98 with DES. Using a candidate gene approach and allele-specific PCR technique for genotyping
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Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK. J. Inflamm. (IF 2.8) Pub Date : 2019-03-18 Urban Alehagen,Jan Alexander,Jan Aaseth,Anders Larsson
Background Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiov