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In Search of an Association Between Genotype and Phenotype in Hereditary Angioedema due to C1-INH Deficiency Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-19 David Loli-Ausejo, Alberto López-Lera, Christian Drouet, Marina Lluncor, Elsa Phillips-Anglés, María Pedrosa, Rosario Cabañas, Teresa Caballero
Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is caused by mutations affecting the SERPING1 gene. Adult patients (≥ 18 years old) diagnosed with C1-INH-HAE were clustered according to a modified SERPING1 gene mutation classification [5]. Demographic, clinical, and laboratory data were studied. Published manuscripts on the genotype/phenotype relationship were reviewed. Eighty-eight
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Clinical Treatment Options in Scleroderma: Recommendations and Comprehensive Review Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-15 Ming Zhao, Jiali Wu, Haijing Wu, Amr H. Sawalha, Qianjin Lu
There are two major clinical subsets of scleroderma: (i) systemic sclerosis (SSc) is a complex systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive fibrosis of the skin and multiple internal organs and (ii) localized scleroderma (LoS), also known as morphea, is confined to the skin and/or subcutaneous tissues resulting in collagen deposition and subsequent fibrosis
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Pathophysiology of Hereditary Angioedema (HAE) Beyond the SERPING1 Gene Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-14 Jyoti Sharma, Ankur Kumar Jindal, Aaqib Zaffar Banday, Anit Kaur, Amit Rawat, Surjit Singh, Hilary Longhurst
Hereditary Angioedema (HAE) is an autosomal dominant disorder characterized clinically by recurrent episodes of swelling involving subcutaneous tissues, gastrointestinal tract, and oro-pharyngeal area. Gene mutations are the most common genetic cause of HAE and observed in more than 90% of patients. More than 700 mutation variants have been described so far. Patients with angioedema who have no mutations
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External Environmental Pollution as a Risk Factor for Asthma Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-12 Jose Chatkin, Liana Correa, Ubiratan Santos
Air pollution is a worrisome risk factor for global morbidity and mortality and plays a special role in many respiratory conditions. It contributes to around 8 million deaths/year, with outdoor exposure being responsible for more than 4.2 million deaths throughout the world, while more than 3.8 million die from situations related to indoor pollution. Pollutant agents induce several respiratory symptoms
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Current and Prospective Targets of Pharmacologic Treatment of Hereditary Angioedema Types 1 and 2 Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-09 Lauré M. Fijen, Konrad Bork, Danny M. Cohn
Hereditary angioedema (HAE) is a rare disease that causes episodic attacks of subcutaneous and submucosal edema, which can be painful, incapacitating, and potentially fatal. These attacks are mediated by excessive bradykinin production, as a result of uncontrolled activation of the plasma kallikrein/kinin system, which is caused by a C1 esterase inhibitor deficiency or dysfunction in HAE types 1 and
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The Roles of Orphan G Protein-Coupled Receptors in Autoimmune Diseases Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-07 Mingming Zhao, Zheyu Wang, Ming Yang, Yan Ding, Ming Zhao, Haijing Wu, Yan Zhang, Qianjin Lu
G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of extracellular signals, such as hormone, neurotransmitter, odor, and light signals. Due to their involvement in a broad range of physiological and pathological processes and their accessibility, GPCRs are widely used as pharmacological targets of treatment
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Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens? Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-07 Joana Costa, Caterina Villa, Kitty Verhoeckx, Tanja Cirkovic-Velickovic, Denise Schrama, Paola Roncada, Pedro M. Rodrigues, Cristian Piras, Laura Martín-Pedraza, Linda Monaci, Elena Molina, Gabriel Mazzucchelli, Isabel Mafra, Roberta Lupi, Daniel Lozano-Ojalvo, Colette Larré, Julia Klueber, Eva Gelencser, Cristina Bueno-Diaz, Araceli Diaz-Perales, Sara Benedé, Simona Lucia Bavaro, Annette Kuehn, Karin
Key determinants for the development of an allergic response to an otherwise ‘harmless’ food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity
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New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-06 Saied Froghi, Charlotte R. Grant, Radhika Tandon, Alberto Quaglia, Brian Davidson, Barry Fuller
Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells is store-operated calcium entry (SOCE), which occurs via calcium release-activated
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Interstitial Lung Disease in Anti-MDA5 Positive Dermatomyositis Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2021-01-06 Wanlong Wu, Li Guo, Yakai Fu, Kaiwen Wang, Danting Zhang, Wenwen Xu, Zhiwei Chen, Shuang Ye
Anti-melanoma differentiation-associated gene 5–positive dermatomyositis (MDA5+ DM) is a rare autoimmune disease predominantly reported in East Asia. MDA5+ DM is an intractable disease with impressively high mortality due to rapid-progressive interstitial lung disease (RPILD). Other typical clinical manifestations comprise DM-specific rash (Gottron’s papules, heliotrope rash) and amyopathic/hypomyopathic
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Correction to: Immunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-27 Tingting Wang, Yuhao Jiao, Xuan Zhang
The online version of the original article can be found at https://doi.org/10.1007/s12016-020-08821-6
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Small Airway Disease in Pediatric Asthma: the Who, What, When, Where, Why, and How to Remediate. A Review and Commentary Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-26 Russell J. Hopp, Mark C. Wilson, M. Asghar Pasha
Asthma affects all portions of the airways. Small airways, however, comprise a substantial component of the conducting lung air flow. In asthma, inflammatory processes can affect the whole respiratory tract, from central to peripheral/small airways. The emphasis in adult and pediatric respiratory disease clinics is to focus on large airway obstruction and reversibility. This information, although valuable
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Inflammasomes and Childhood Autoimmune Diseases: A Review of Current Knowledge Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-25 Chin-An Yang, Bor-Luen Chiang
Inflammasomes are multiprotein complexes capable of sensing pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and cellular perturbations. Upon stimulation, the inflammasomes activate the production of the pro-inflammatory cytokines IL-1β and IL-18 and induce gasdermin D-mediated pyroptosis. Dysregulated inflammasome signaling could lead to hyperinflammation
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The Application of Single-Cell RNA Sequencing in Studies of Autoimmune Diseases: a Comprehensive Review Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-25 Mingming Zhao, Jiao Jiang, Ming Zhao, Christopher Chang, Haijing Wu, Qianjin Lu
Complex composition is one of the most important features of the immune system, involving many types of organs, tissues, cells, and molecules that perform immune functions. The normal function of each component of the immune system is the guarantee for maintaining the relatively stable immune function of the body. When the self-immune tolerance mechanism of the body is unregulated or destroyed, the
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IL-23/IL-17 Axis in Inflammatory Rheumatic Diseases Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-13 Hao Li, George C. Tsokos
In inflammatory rheumatic disorders, the immune system attacks and damages the connective tissues and invariably internal organs. During the past decade, remarkable advances having been made towards our understanding on the cellular and molecular mechanisms involved in rheumatic diseases. The discovery of IL-23/IL-17 axis and the delineation of its important role in the inflammation led to the introduction
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Immunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-12 Tingting Wang, Yuhao Jiao, Xuan Zhang
Autoimmune diseases (AIDs) are characterized with aberrant immune responses and their respective signaling pathways controlling cell differentiation, death, and survival. Cell metabolism is also an indispensable biochemical process that provides the very fundamental energy and materials. Accumulating evidences implicate that metabolism pathways have critical roles in determining the function of different
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The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-10 Ambika Sharma, Sargeet Kaur, Malay Sarkar, B. C. Sarin, Harish Changotra
Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases limiting the airflow due to narrowing of airways, chronic bronchitis and emphysema that leads to difficulties in breathing. Chronic inflammation is another important characteristic of COPD which leads to immune cell infiltration and helps in the alveolar destruction. Pathology of COPD is driven by various environmental
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Distinctive Clinical Characteristics and Outcome of ILD-Onset Rheumatoid Arthritis and ACPA-Positive ILD: a Longitudinal Cohort of 282 Cases Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-10 Ru-Xuan Chen, Li-Dan Zhao, Xin-Yue Xiao, Lan Song, Hua-Yang Du, Zuo-Jun Xu, Rui-E Feng, Hua-Xia Yang, Yun-Yun Fei, Wen Zhang, Feng-Chun Zhang, Hua Chen, Xuan Zhang
The aim of this study is to investigate the clinical features and outcome of interstitial lung disease (ILD)-onset rheumatoid arthritis (RA) and anti-citrullinated protein antibody (ACPA)-positive ILD-only patients. Arthritis-onset and ILD-onset RA-ILD and ACPA-positive ILD-only patients consecutively admitted to Peking Union Medical College Hospital from January 2008 to December 2017 were enrolled
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Management of Severe Refractory Systemic Lupus Erythematosus: Real-World Experience and Literature Review Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-07 Huaxia Yang, Huazhen Liu, Ziyue Zhou, Lidan Zhao, Yunyun Fei, Hua Chen, Fengchun Zhang, Xuan Zhang
Systemic lupus erythematosus (SLE) is a highly heterogeneous disease affecting multiple organs and is characterized by an aberrant immune response. Although the mortality of SLE has decreased significantly since the application of glucocorticoids, severe or refractory SLE can potentially cause irreversible organ damage and contribute to the disease morbidity and mortality. Early recognition of severe
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Neutrophils in the Pathogenesis of Rheumatic Diseases: Fueling the Fire Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-05 Yudong Liu, Mariana J. Kaplan
Systemic rheumatic diseases are a heterogeneous group of disorders characterized by profound immune dysregulation. Recent discoveries have led to a significant resurgence of interest in neutrophils as shapers of immune dysregulation and as triggers of organ damage in rheumatic diseases. Neutrophils contribute to the initiation, promotion, and perpetuation of immune dysregulation through a variety of
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Predictive Features and Clinical Presentation of Interstitial Lung Disease in Inflammatory Myositis Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-11-03 Tamara Vojinovic, Ilaria Cavazzana, Paolo Ceruti, Micaela Fredi, Denise Modina, Marialma Berlendis, Franco Franceschini
Interstitial lung disease (ILD) represents one of the most severe extra-muscular features of idiopathic inflammatory myositis (IIM). We aimed to identify any clinical and serological predictors of ILD in a monocentric cohort of 165 IIM patients. ILD+ patients were defined as having restrictive impairment in lung function tests and signs of ILD at chest high-resolution computed tomography (HRCT). Available
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Use of Ultraviolet Blood Irradiation Against Viral Infections Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-10-07 Alberto Boretti, Bimal Banik, Stefania Castelletto
Ultraviolet blood irradiation (UBI) was used with success in the 1930s and 1940s for a variety of diseases. Despite the success, the lack of understanding of the detailed mechanisms of actions, and the achievements of antibiotics, phased off the use of UBI from the 1950s. The emergence of novel viral infections, from HIV/AIDS to Ebola, from SARS and MERS, and SARS-CoV-2, bring back the attention to
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Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens? Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-09-02 Joana Costa,Simona Lucia Bavaro,Sara Benedé,Araceli Diaz-Perales,Cristina Bueno-Diaz,Eva Gelencser,Julia Klueber,Colette Larré,Daniel Lozano-Ojalvo,Roberta Lupi,Isabel Mafra,Gabriel Mazzucchelli,Elena Molina,Linda Monaci,Laura Martín-Pedraza,Cristian Piras,Pedro M Rodrigues,Paola Roncada,Denise Schrama,Tanja Cirkovic-Velickovic,Kitty Verhoeckx,Caterina Villa,Annette Kuehn,Karin Hoffmann-Sommergruber
This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of
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Equine Hypersensitivity: the Dark Horse of Allergy. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-09-02 Julie Davenport,Derek Smith
A significant amount of medical literature has been published on the prevalence and treatment modalities of allergies to common household pets like dogs and cats. Although sensitization rates to horses are high in many urban areas, allergies to horses are rarely discussed. In order for allergists to treat effectively horse-allergic patients, they must be aware of various clinical presentations and
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Clinical Manifestations and Management of Pediatric Behçet's Disease. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-08-07 Ya-Chiao Hu,Bor-Luen Chiang,Yao-Hsu Yang
Behçet’s disease (BD) is a chronic, vasculitic disorder affecting all sizes of vessels. The disease rarely onsets at childhood and an early diagnosis is often challenging. Oral ulceration and fever of unknown cause are common initial manifestations that might confuse other inflammatory disorders. The clinical manifestation pattern in pediatric BD is heterogeneous and varies in different genders, ethnicities
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A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-08-01 Victoria Mutua,Laurel J Gershwin
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory
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Autoimmunity in 2019. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-07-29 Carlo Selmi
Based on the PubMed data, we have been performing a yearly evaluation of the publications related to autoimmune diseases and immunology to ascertain the relative weight of the former in the scientific literature. It is particularly intriguing to observe that despite the numerous new avenues of immune-related mechanisms, such as cancer immunotherapy, the proportion of immunology manuscripts related
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Interleukin-35 Promotes Th9 Cell Differentiation in IgG4-Related Disorders: Experimental Data and Review of the Literature. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-07-25 Jun Zhang,Min Lian,Bo Li,Lixia Gao,Toshihiro Tanaka,Zhengrui You,Yiran Wei,Yong Chen,Yikang Li,You Li,Bingyuan Huang,Ruqi Tang,Qixia Wang,Qi Miao,Yanshen Peng,Jingyuan Fang,Zhexiong Lian,Kazuichi Okazaki,Xiao Xiao,Weici Zhang,Xiong Ma
IgG4-related disease (IgG4-RD) is characterized by intense infiltration of IgG4-positive plasma cells in affected organs. However, the mechanisms acting in the immune responses in IgG4-RD are not fully understood. The aim of this study was to dissect the mechanism underlying the immunoglobulin class switch in IgG4-RD by addressing the crosstalk between IL-35-producing and Th9 cells. The expression
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Fish Allergy: Fishing for Novel Diagnostic and Therapeutic Options. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-07-25 D Dijkema,J A M Emons,A A J M Van de Ven,J N G Oude Elberink
Fish allergy is one of the most common food allergies. The currently recommended treatment commonly consists of avoiding all fish species. Recent literature suggests that these recommendations are overprotective for the majority of fish-allergic patients. This review summarizes recent findings and provides practical information regarding management of fish allergy in the individual patient. After precise
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Machine Learning in Rheumatic Diseases. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-07-17 Mengdi Jiang,Yueting Li,Chendan Jiang,Lidan Zhao,Xuan Zhang,Peter E Lipsky
With advances in information technology, the demand for using data science to enhance healthcare and disease management is rapidly increasing. Among these technologies, machine learning (ML) has become ubiquitous and indispensable for solving complex problems in many scientific fields, including medical science. ML allows the development of guidelines and framing of the evaluation system for complex
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Current and Future Monoclonal Antibodies in the Treatment of Atopic Dermatitis. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-07-02 Peter Ip Fung Chun,Heather Lehman
Atopic dermatitis is a common immunologic skin disease. Mild atopic dermatitis can be managed with emollients and topical therapies such as low potency topical steroids, which have a favorable safety profile. Severe atopic dermatitis, in contrast, is a challenging disease to treat. Topical therapies are typically inadequate for control of severe atopic dermatitis. When topical therapies fail, the mainstay
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Treatments for Childhood Atopic Dermatitis: an Update on Emerging Therapies. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-06-30 Chia-Yu Chu
Atopic dermatitis (AD) is generally considered a T helper type 2–dominated disease. Pediatric AD is usually less severe than adult AD, but it may present as moderate to severe lesions that are inadequately managed by current modalities including emollients/moisturizers, topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and even systemic immunosuppressants (such as cyclosporine
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Health Effects of Trimellitic Anhydride Occupational Exposure: Insights from Animal Models and Immunosurveillance Programs. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-06-27 Debajyoti Ghosh,Jonathan A Bernstein
Acid anhydrides are used by chemical industries as plasticizers. Trimellitic acid (TMA) is an acid anhydride widely utilized in factories to produce paints, varnishes, and plastics. In addition to causing direct irritant effects, TMA can augment antibody responses in exposed factory workers leading to occupational asthma. Therefore, industries producing TMA have implemented occupational immunosurveillance
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Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-06-17 Jiao Jiang,Ming Zhao,Christopher Chang,Haijing Wu,Qianjin Lu
Type I interferons (IFN-Is) are a very important group of cytokines that are produced by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral, antitumor, and anti-proliferative effects, as well are associated with the initiation and maintenance of autoimmune disorders. Studies have shown that aberrantly expressed IFN-Is and/or type I IFN-inducible gene signatures in the
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Chronic Granulomatous Disease: a Comprehensive Review. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-06-10 Hsin-Hui Yu,Yao-Hsu Yang,Bor-Luen Chiang
Chronic granulomatous disease (CGD) is a primary immunodeficiency of phagocyte function due to defective NADPH oxidase (phox). Compared with the common types of CYBB/gp91phox, NCF1/p47phox, and CYBA/p22phox deficiency, NCF4/p40phox deficiency is a mild and atypical form of CGD without invasive bacterial or fungal infections. It can be diagnosed using serum-opsonized E.coli as a stimulus in dihydrorhodamine
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Specialized Pro-Resolving Lipid Mediators: Emerging Therapeutic Candidates for Multiple Sclerosis. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-06-03 Insha Zahoor,Shailendra Giri
Multiple sclerosis (MS) is a neuroinflammatory disease in which unresolved and uncontrolled inflammation disrupts normal cellular homeostasis and leads to a pathological disease state. It has long been recognized that endogenously derived metabolic by-products of omega fatty acids, known as specialized pro-resolving lipid mediators (SPMs), are instrumental in resolving the pathologic inflammation.
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Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn's Disease. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-30 Chengcen Guo,Jun Shen
Crohn’s disease (CD) is a type of inflammatory bowel disease (IBD) and affects diverse segments of the entire gastrointestinal tract. Although the underlying causes of CD are not completely known, it is believed that disruption of the intestinal barrier and cell polarity may contribute to pathogenesis. The formation of the intestinal epithelial barrier, which is mainly regulated by cytoskeletal modulations
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COVID-19 and Asthma: Reflection During the Pandemic. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-28 Shuang Liu,Yuxiang Zhi,Sun Ying
Coronavirus disease 2019 (COVID-19) is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and abnormal, overactivated innate immunity and “cytokine storms” have been proposed as potential pathological mechanisms for rapid COVID-19 progression. Theoretically, asthmatic patients should have increased susceptibility and severity for SARS-CoV-2
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Omalizumab Updosing in Chronic Spontaneous Urticaria: an Overview of Real-World Evidence. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-16 Martin Metz,Zahava Vadasz,Emek Kocatürk,Ana M Giménez-Arnau
Chronic spontaneous urticaria (CSU) is defined as the spontaneous development of itchy hives and/or angioedema due to known or unknown causes that last for at least 6 weeks. At any given time, CSU is believed to affect 0.5-1% of the global population. Omalizumab (a recombinant, humanized anti-immunoglobulin-E antibody) is the only approved treatment for antihistamine refractory CSU. However, ~ 30%
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Immunobiology of T Cells in Sjögren's Syndrome. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-11 Yuan Yao,Jin-Fen Ma,Christopher Chang,Ting Xu,Cai-Yue Gao,M Eric Gershwin,Zhe-Xiong Lian
Sjögren's syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its pathogenesis involves an inflammatory process that is characterized by lymphocytic infiltration into exocrine glands and other tissues. Although the development of ectopic lymphoid tissue and overproduction of autoantibodies by hyperactive
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Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-06 Khadijeh Koushki,Sanaz Keshavarz Shahbaz,Kazem Mashayekhi,Mahvash Sadeghi,Zeinab Deris Zayeri,Mahdieh Yousefi Taba,Maciej Banach,Khalid Al-Rasadi,Thomas P Johnston,Amirhossein Sahebkar
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome
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Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-06 Tesfaye B Mersha,Yashira Afanador,Elisabet Johansson,Steven P Proper,Jonathan A Bernstein,Marc E Rothenberg,Gurjit K Khurana Hershey
Allergic diseases are highly complex with respect to pathogenesis, inflammation, and response to treatment. Current efforts for allergic disease diagnosis have focused on clinical evidence as a binary outcome. Although outcome status based on clinical phenotypes (observable characteristics) is convenient and inexpensive to measure in large studies, it does not adequately provide insight into the complex
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Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-05-06 Laure Frumholtz,Sara Laurent-Roussel,Dan Lipsker,Benjamin Terrier
Cutaneous vasculitis is an inflammatory disease affecting the dermal blood vessel walls. The skin is a privileged organ in the setting of vasculitis since it is easily accessible for physical examination and safe biopsy, allowing an accurate characterization of inflammatory lesions. The skin is often involved. Also, cutaneous vasculitis can reflect a cutaneous component of a systemic vasculitis, a
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Clinical Pathway for Early Diagnosis of COVID-19: Updates from Experience to Evidence-Based Practice. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-04-24 Guogang Xu,Yongshi Yang,Yingzhen Du,Fujun Peng,Peng Hu,Runsheng Wang,Ming Yin,Tianzhi Li,Lei Tu,Jinlyu Sun,Taijiao Jiang,Christopher Chang
The COVID-19 pandemic is a significant global event in the history of infectious diseases. The SARS-CoV-2 appears to have originated from bats but is now easily transmissible among humans, primarily through droplet or direct contact. Clinical features of COVID-19 include high fever, cough, and fatigue which may progress to ARDS. Respiratory failure can occur rapidly after this. The primary laboratory
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Influence of Cosmetic Type and Distribution Channel on the Presence of Regulated Fragrance Allergens: Study of 2044 Commercial Products. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-04-22 C Couteau,T Morin,H Diarra,L Coiffard
Contact dermatitis linked to cosmetic products is a very common reason for visits to the dermatologist, and in more than half the cases, it is due to an allergic reaction. Fragrances are most often the culprit. The aim of the study was to describe the common fragrance allergens in different categories of cosmetic products available on the European market. We wanted to assess the influence of cosmetic
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The Aryl Hydrocarbon Receptor (AHR) as a Potential Target for the Control of Intestinal Inflammation: Insights from an Immune and Bacteria Sensor Receptor Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-04-11 Larissa Pernomian, Murillo Duarte-Silva, Cristina Ribeiro de Barros Cardoso
The aryl hydrocarbon receptor (AHR) is widely expressed in immune and non-immune cells of the gut and its activation has been correlated to the outcome of inflammatory bowel diseases (IBD). In ulcerative colitis and Crohn’s disease, there is an excessive chronic inflammation with massive accumulation of leukocytes in the gut, in an attempt to constrain the invasion of pathogenic microorganisms on the
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New Insights into Asthma Inflammation: Focus on iNKT, MAIT, and γδT Cells Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-04-03 Jefferson Russo Victor, Guillaume Lezmi, Maria Leite-de-Moraes
Asthma is a chronic immunological disease affecting all age groups, but often starting in childhood. Although it has long been ascribed to a single pathology, recent studies have highlighted its heterogeneity due to the potential involvement of various pathogenic mechanisms. Here, we present our current understanding of the role of innate-like T (ILT) cells in asthma pathogenesis. These cells constitute
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Natural Antibodies: from First-Line Defense Against Pathogens to Perpetual Immune Homeostasis. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-06-03 Mohan S Maddur,Sébastien Lacroix-Desmazes,Jordan D Dimitrov,Michel D Kazatchkine,Jagadeesh Bayry,Srini V Kaveri
Natural antibodies (nAbs) are most commonly defined as immunoglobulins present in the absence of pathological conditions or deliberate immunizations. Occurrence of nAbs in germ- and antigen-free mice suggest that their production is driven, at least in part, by self-antigens. Accordingly, nAbs are constituted of natural autoantibodies (nAAbs), and can belong to the IgM, IgG, or IgA subclasses. These
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Platelets and IgE: Shaping the Innate Immune Response in Systemic Lupus Erythematosus. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-06-28 Benoit Brilland,Marc Scherlinger,Liliane Khoryati,Julien Goret,Pierre Duffau,Estibaliz Lazaro,Manon Charrier,Vivien Guillotin,Christophe Richez,Patrick Blanco
Systemic lupus erythematosus (SLE) is a systemic and potentially fatal autoimmune disease. SLE pathophysiology is complex and involves the interplay between the innate and adaptive immune systems, with a particularly significant role for type I interferons. Recently, the participation of other actors such as platelets and IgE has been described in SLE. On the one hand, platelets activated by different
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Toll-Like Receptors, Infections, and Rheumatoid Arthritis. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-05-29 Marina I Arleevskaya,R V Larionova,Wesley H Brooks,Eléonore Bettacchioli,Yves Renaudineau
Toll-like receptors (TLR) that belong to the group of protein recognition receptor (PPR) provide an innate immune response following the sensing of conserved pathogen-associated microbial patterns (PAMPs) and changes in danger-associated molecular patterns (DAMPs) that are generated as a consequence of cellular injury. Analysis of the TLR pathway has moreover offered new insights into the pathogenesis
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Animal Models of Autoimmune Liver Diseases: a Comprehensive Review. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-02-19 Shou-Pei Liu,Zhen-Hua Bian,Zhi-Bin Zhao,Jinjun Wang,Weici Zhang,Patrick S C Leung,Liang Li,Zhe-Xiong Lian
Autoimmune liver diseases (AILDs) are potentially life-threatening chronic liver diseases which include autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and recently characterized IgG4-related sclerosing cholangitis. They are caused by immune attack on hepatocytes or bile ducts, with different mechanisms and clinical manifestations. The etiologies of AILDs include
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The Innate Part of the Adaptive Immune System. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-06-01 Sophie Hillion,Marina I Arleevskaya,Patrick Blanco,Anne Bordron,Wesley H Brooks,Jean Yves Cesbron,Srini Kaveri,Eric Vivier,Yves Renaudineau
The innate immune response provides a first line of defense against common microorganisms and, for more complex and/or recurring situations where pathogens must be eliminated, an adaptive immune response has emerged and evolved to provide better protection against subsequent infections. However, such dichotomy has to be reevaluated because innate B cells (e.g., B1 and marginal zone B cells) and the
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JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-06-04 Amandine Charras,Pinelopi Arvaniti,Christelle Le Dantec,Marina I Arleevskaya,Kaliopi Zachou,George N Dalekos,Anne Bordon,Yves Renaudineau
Pathogenesis of primary Sjögren's syndrome (SjS) remains obscure. However, recent data demonstrate the implication of epigenetic alterations in the DNA methylation/hydroxymethylation process in SjS mostly affecting genes regulated by two innate cytokines, interferon α (IFNα) and IFNγ as well as the oxidative stress pathways. The Janus kinase (JAK) signal transducer and activator of transcription (STAT)
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Complement System: a Neglected Pathway in Immunotherapy. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-05-29 Anne Bordron,Cristina Bagacean,Adrian Tempescul,Christian Berthou,Eléonore Bettacchioli,Sophie Hillion,Yves Renaudineau
Approved for the treatment of autoimmune diseases, hematological malignancies, and solid cancers, several monoclonal antibodies (mAb) make use of complement in their mechanism of action. Such an assessment is based on comprehensive investigations that used mouse models, in vitro studies, and analyses from patients at initiation (basal level to highlight deficiencies) and after treatment initiation
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The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2019-12-13 Federica Defendi, Nicole M. Thielens, Giovanna Clavarino, Jean-Yves Cesbron, Chantal Dumestre-Pérard
Abstract The complement is a powerful cascade of the innate immunity and also acts as a bridge between innate and acquired immune defence. Complement activation can occur via three distinct pathways, the classical, alternative and lectin pathways, each resulting in the common terminal pathway. Complement activation results in the release of a range of biologically active molecules that significantly
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JAK Inhibitors: Prospects in Connective Tissue Diseases Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-03-28 Hanxiao You, Dong Xu, Jiuliang Zhao, Jing Li, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
The dysregulation of the JAK–STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review, we elucidate the involvement of the JAK–STAT signaling pathway in the pathogenesis
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New Concepts and Technological Resources in Patient Education and Asthma Self-Management. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-03-25 Pavadee Poowuttikul,Divya Seth
Asthma is a chronic disease that is associated with significant morbidity and mortality. In general, the use of technology resources or electronic health (e-health) has been shown to have beneficial effects on patients with asthma. E-health can impact a broad section of patients and can be cost-effective and associated with high patient satisfaction. E-health may enable remote delivery of care, as
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Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-03-25 Daniel Elieh Ali Komi,Farzaneh Shafaghat,Mark Christian
Excessive fatty acids and glucose uptake support the infiltration of adipose tissue (AT) by a variety of immune cells including neutrophils, pro-inflammatory M1 macrophages, and mast cells (MCs). These cells promote inflammation by releasing pro-inflammatory mediators. The involvement of MCs in AT biology is supported by their accumulation in the AT of obese individuals along with significantly higher
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Immunogenetics of Kawasaki disease. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-03-21 Rajni Kumrah,Pandiarajan Vignesh,Amit Rawat,Surjit Singh
Kawasaki disease (KD) is a medium vessel vasculitis that affects young children. Despite extensive research over the last 50 years, the etiology of KD remains an enigma. Seasonal change in wind patterns was shown to have correlation with the epidemics of KD in Japan. Occurrence of disease in epidemiological clusters, seasonal variation, and a very low risk of recurrence suggest that KD is triggered
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Correction to: Targeted Anti-IL-5 Therapies and Future Therapeutics for Hypereosinophilic Syndrome and Rare Eosinophilic Conditions. Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-03-18 Aasha Harish,Stanley A Schwartz
The original version of this article unfortunately contained a mistake in the fifth paragraph of the “Conclusion” section.
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Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring Clinic. Rev. Allerg Immunol. (IF 6.437) Pub Date : 2020-03-10 Chun-Min Kang, Bor-Luen Chiang, Li-Chieh Wang
Atopic dermatitis (AD) is the leading chronic skin inflammatory disease and the initial manifestation of atopic march. Available evidence supports the notion that primary prevention early in life leads to a decreased incidence of AD, thus possibly decreasing the subsequent occurrence of atopic march. Nutritional status is essential to a proper functioning immune system and is valued for its important