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Wip1 Aggravates the Cerulein-Induced Cell Autophagy and Inflammatory Injury by Targeting STING/TBK1/IRF3 in Acute Pancreatitis Inflammation (IF 3.212) Pub Date : 2021-01-08 Yinghui Song, Zhihua Zhang, Zhangtao Yu, Guoyi Xia, Yizhi Wang, Le Wang, Chuang Peng, Bo Jiang, Sulai Liu
Acute pancreatitis (AP) is an inflammatory reaction of pancreatic tissue self-digestion, edema, hemorrhage, and even necrosis after the activation of pancreatic enzymes in the pancreas caused by a variety of etiologies. This study was aimed to explore the functions and mechanism of Wip1 in AP. Twenty male SD rats were randomly assigned into 2 groups (control group: saline treatment; AP group: cerulein
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Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis Inflammation (IF 3.212) Pub Date : 2021-01-08 Shang-Ping Zhao, Can Yu, Ming-Shi Yang, Zuo-Liang Liu, Bing-Chang Yang, Xue-Fei Xiao
Acute pancreatitis (AP) is an inflammatory, complicated pancreatic disease, carrying significant morbidity and mortality. However, the molecular and cellular mechanisms involved in AP pathogenesis remain to be elucidated. Here, we explore the role of FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) in AP progression. Caerulein with or without LPS- induced or taurolithocholic acid 3-sulfate
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A Regulatory Role of Chemokine Receptor CXCR3 in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Emphysema Inflammation (IF 3.212) Pub Date : 2021-01-07 Lun Li, Yi Liu, Chin Chiu, Yang Jin, Weixun Zhou, Min Peng, Lung-Chi Chen, Qinghua Sun, Jinming Gao
Chronic obstructive pulmonary disease (COPD)/pulmonary emphysema is driven by the dysregulated airway inflammation and primarily influenced by the interaction between cigarette smoking (CS) and the individual’s susceptibility. The inflammation in COPD involves both innate and adaptive immunity. By binding to its specific ligands, chemokine receptor CXCR3 plays an important role in regulating tissue
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TRIM Proteins in Inflammation: from Expression to Emerging Regulatory Mechanisms Inflammation (IF 3.212) Pub Date : 2021-01-07 Luting Yang, Haibin Xia
Inflammation is an immune response to exogenous or endogenous insults that helps to maintain the tissue homeostasis under stressful conditions. Depending on the differential types of insults, inflammation is classified into microbial, autoimmune, metabolic, allergic, and physical inflammation. With regard to its involvement in the pathogenesis of most of human diseases, dissecting the key molecules
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Sappanone A Protects Against Inflammation, Oxidative Stress and Apoptosis in Cerebral Ischemia-Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress Inflammation (IF 3.212) Pub Date : 2021-01-07 Meihua Wang, Zhilin Chen, Lei Yang, Lei Ding
Endoplasmic reticulum stress is an important contributor to the cerebral ischemic injury. Sappanone A (SA), a kind of natural homoisoflavanone extracted from Caesalpinia sappan L, has been evidenced to exhibit anti-inflammatory and antioxidative properties. The present study aimed to investigate the potential neuroprotective effects of SA in cerebral ischemia-reperfusion injury. The potential neuroprotective
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CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway Inflammation (IF 3.212) Pub Date : 2021-01-06 Xiangyuan Cao, Yida Wang, Liang Gao
Cerebral ischemia-reperfusion (I/R) injury is an inflammation-related disease. CHRFAM7A can regulate inflammatory responses. Therefore, the present study investigated the mechanism of CHRFAM7A in cerebral I/R injury. CHRFAM7A expression and inflammatory cytokine levels in patients with cerebral I/R injury and oxygen-glucose deprivation/reperfusion (OGD/R)-treated microglia were detected. The proliferation
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The Role of α7nAChR-Mediated Cholinergic Anti-inflammatory Pathway in Immune Cells Inflammation (IF 3.212) Pub Date : 2021-01-06 Yi-jin Wu, Li Wang, Chao-fan Ji, Shao-fei Gu, Qin Yin, Jian Zuo
Alpha 7 nicotinic acetylcholine receptor (α7nAChR) is widely distributed in the nervous and non-cholinergic immune systems. It is necessary for the cholinergic transmitter to participate in the regulation of inflammatory response and is the key element of cholinergic anti-inflammatory pathway (CAP). Because of the profound impact of CAP on the immune system, α7nAChR is considered as a potential therapeutic
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Is there an Inflammation Role for MYD88 in Rheumatoid Arthritis? Inflammation (IF 3.212) Pub Date : 2021-01-06 Isaura Isabelle Fonseca Gomes da Silva, Camilla Albertina Dantas Lima, José Eduardo Adelino Silva, Eliezer Rushansky, Maria Helena Queiroz Araujo Mariano, Patrícia Rolim, Renê Donizeti Ribeiro Oliveira, Paulo Louzada-Júnior, Fabricio Oliveira Souto, Sergio Crovella, Jaqueline de Azevêdo Silva, Paula Sandrin-Garcia
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease with strong genetic influence, especially upon immune response components. Several cytokines from the toll-like receptors activation pathway display recognized role for RA establishment. However, few studies have verified the role of key mediators such as MYD88 gene and its genetic variants. In the present study, we aim to evaluate
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Progesterone Attenuates Brain Inflammatory Response and Inflammation-Induced Increase in Immature Myeloid Cells in a Mouse Model Inflammation (IF 3.212) Pub Date : 2021-01-06 Ola Gutzeit, Linoy Segal, Ben Korin, Roee Iluz, Nizar Khatib, Fadwa Dabbah-Assadi, Yuval Ginsberg, Ofer Fainaru, Michael G. Ross, Zeev Weiner, Ron Beloosesky
Progesterone has been shown to regulate immunity during pregnancy, and progesterone administration may reduce inflammation-induced preterm labor. We sought to determine the maternal brain immune response to LPS-induced inflammation in pregnant and non-pregnant mice and whether additional progesterone supplementation attenuates this response. Pregnant (P: n = 9) and non-pregnant mice (NP: n = 9) were
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Poly-dispersed Acid-Functionalized Single-Walled Carbon Nanotubes (AF-SWCNTs) Are Potent Inhibitor of BCG Induced Inflammatory Response in Macrophages Inflammation (IF 3.212) Pub Date : 2021-01-05 Deepika Bhardwaj, Rajiv K. Saxena
The present study is focused on the modulation of Mycobacterium bovis BCG-induced inflammatory response by poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) in macrophages. Flow cytometric and confocal microscopy studies indicated that both BCG and AF-SWCNTs were efficiently internalized by RAW 264.7 and MH-S macrophage cell lines and were essentially localized in the cytoplasmic
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Tadalafil Alleviates LPS-Induced Inflammation and Oxidative Stress of RWPE-1 Cell by Regulating the Akt/Nrf2 Signaling Pathway Inflammation (IF 3.212) Pub Date : 2021-01-05 Xiaoqing Song, Guodong Chen, Caixia Li, Chunyan Yang, Yun Deng
Tadalafil (TAD) is primarily a treatment drug for erectile dysfunction. Studies have shown that TAD has a therapeutic effect on prostatitis, but the specific mechanism has not been reported. LPS induced RWPE-1 cells to form a model of chronic nonbacterial prostatitis (CNP). Cell activity was measured by MTT assay. Apoptosis was detected by TUNEL assay. Western blot was used to detect the expression
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Steroid Receptor Coactivator-3 Is Required for Inhibition of the Intestinal Muscularis Inflammatory Response of Postoperative Ileus in Mice Inflammation (IF 3.212) Pub Date : 2021-01-04 Kang Zou, Wenbo Chen, Jun Dai, Pingli Mo, Chundong Yu, Jianming Xu, Sangang Wu, Rengong Zhuo, Guoqiang Su
Inflammation theory has suggested that the pathogenesis of postoperative ileus (POI) involves the steroid receptor coactivator-3 (SRC-3). Therefore, we investigated the role of SRC-3 in the muscles of the small intestine using a mouse POI model. Here, we reported that intestinal manipulation (IM) significantly reduced the extent of phenol red migration in the entire gastrointestinal tract, and the
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Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1 Inflammation (IF 3.212) Pub Date : 2021-01-04 Tingting Wang, Jiakai Wang, Tao Sun, Yishuo Li
Arthritis is characterized by irreversible joint destruction and presents a global health burden. Natural alternatives to synthetic drugs have been gaining popularity for their safety and effectiveness. Juglanin has demonstrated a range of anti-inflammatory effects in various tissues and cell types. However, the pharmacological function of Juglanin in arthritis and chondrocytes has been little studied
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Long Non-coding RNA MEG3 Alleviated Ulcerative Colitis Through Upregulating miR-98-5p-Sponged IL-10 Inflammation (IF 3.212) Pub Date : 2021-01-04 Yan Wang, Nan Wang, Lianlian Cui, Yan Li, Zhenfeng Cao, Xing Wu, Qianhan Wang, Bo Zhang, Caixia Ma, Yanbo Cheng
Ulcerative colitis (UC) is a refractory chronic colitis disease with the particularly complex cause. Recently, long noncoding RNAs (lncRNAs) have been reported to be related to the development of UC. LncRNA MEG3 has been proved to play an anti-inflammatory role in a variety of inflammatory diseases, which share similar pathogenesis with UC, indicating the potential involvement of lncRNA MEG3 in UC
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Betulin Alleviates Myocardial Ischemia–Reperfusion Injury in Rats via Regulating the Siti1/NLRP3/NF-κB Signaling Pathway Inflammation (IF 3.212) Pub Date : 2021-01-04 Chenchen Yu, Xixi Cai, Xuejiao Liu, Jianlong Liu, Na Zhu
To study the effects of betulin (BE) on myocardial ischemia–reperfusion (I/R) injury in rats, electrocardiogram (ECG) was detected by an electrocardiograph; myocardial infarction was evaluated by triphenyltetrazolium (TTC) staining, serum biochemical indicators myocardial enzymes creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), serum superoxide dismutase (SOD), glutathione
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High-Density-Immune-Complex Regulatory Macrophages Promote Recovery of Experimental Colitis in Mice Inflammation (IF 3.212) Pub Date : 2021-01-04 Tamara Cristina Moreira Lopes, Gregório Guilherme Almeida, Izabela Aparecida Souza, Diego Costa Borges, Wanderson Geraldo de Lima, Pedro Henrique Dias Moura Prazeres, Alexander Birbrair, Rosa Maria Esteves Arantes, David M. Mosser, Ricardo Goncalves
Macrophages not only play a fundamental role in the pathogenesis of inflammatory bowel disease (IBD), but they also play a major role in preserving intestinal homeostasis. In this work, we evaluated the role of macrophages in IBD and investigated whether the functional reprogramming of macrophages to a very specific phenotype could decrease disease pathogenesis. Thus, macrophages were stimulated in
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Serum Exosomal microRNA-27-3p Aggravates Cerebral Injury and Inflammation in Patients with Acute Cerebral Infarction by Targeting PPARγ Inflammation (IF 3.212) Pub Date : 2021-01-04 Zhinan Ye, Jingchun Hu, Hao Xu, Bin Sun, Yong Jin, Yaping Zhang, Jianli Zhang
Acute cerebral infarction (ACI) possesses high mortality. Exosomes present in serum have potential application value in ACI diagnosis. This study investigated the mechanism of serum exosomes in ACI. Serum exosomes isolated from ACI patients and normal people were identified and then injected into the established middle cerebral artery occlusion (MCAO) rat model to evaluate cerebral injury and inflammation
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Mitigation of Gliadin-Induced Inflammation and Cellular Damage by Curcumin in Human Intestinal Cell Lines Inflammation (IF 3.212) Pub Date : 2021-01-04 Kunj Bihari Gupta, Anil K. Mantha, Monisha Dhiman
Wheat is a major diet from many years; apart from its nutritious value, the wheat protein gliadin is responsible for many inflammatory diseases like celiac disease (CD), and non-celiac gluten sensitivity (NCGS). In this study, the gliadin-induced inflammation and associated cellular damage along with the protective role of curcumin was evaluated using human intestinal cell lines (HCT-116 and HT-29)
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Correction to: Destructive Roles of Fibroblast-Like Synoviocytes in Chronic Inflammation and Joint Damage in Rheumatoid Arthritis Inflammation (IF 3.212) Pub Date : 2020-12-14 Maryam Masoumi, Hamidreza Bashiri, Hossein Khorramdelazad, Khadijeh Barzaman, Nader Hashemi, Hale Abdoli Sereshki, Amirhossein Sahebkar, Jafar Karami
A Correction to this paper has been published: https://doi.org/https://doi.org/10.1007/s10753-020-01402-x
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Correction to: Periodontal Disease Impairs Muscle Recovery by Modulating the Recruitment of Leukocytes. Inflammation (IF 3.212) Pub Date : 2020-09-11 Bárbara Capitanio de Souza,Bibiana Franzen Matte,André Luiz Lopes,Bruno Costa Teixeira,Marcelo Lazzaron Lamers
The original version of this article contained mistakes, and the authors would like to correct them.
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Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model. Inflammation (IF 3.212) Pub Date : 2020-09-18 Karuna Sharma,Sunil Kumar Bose,Sanjay Chhibber,Kusum Harjai
Biofilms of Pseudomonas aeruginosa can cause complicated urinary tract infections especially in people with indwelling catheters which may result in pyelonephritis. Microorganisms in biofilm demonstrate high resistance to both antibiotics and host protection mechanisms, often resulting in chronic and difficult-to-treat infections. This study is aimed to assess in vivo and ex vivo efficacy of Zingerone
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MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis Inflammation (IF 3.212) Pub Date : 2020-09-29 Xiaojun Su, Hongtao Zhang, Haidong Wang, Pengfei Sun
Studies have found that N-myc downstream–regulated gene 2 (Ndrg2) is involved in the progression of rheumatoid arthritis (RA); however, the specific mechanism still remains unclear. Gene expression profiles in the tibial joints of the collagen-induced rheumatoid arthritis model were obtained using Gene Expression Omnibus database. Western blot and real-time PCR were respectively performed to determine
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Screen the Effective Components of Lycopodii herba on Rheumatoid Arthritis with the Aid of Spectrum-Effect Relationship and Uncover its Potential Mechanism. Inflammation (IF 3.212) Pub Date : 2020-09-10 Zhen Yang,Qingsheng Yin,Jing Ma,Changshuo Yang,Yuanyuan Sheng,Lili Song,Tan Pang,Pengwei Zhuang,Hong Guo,Yanjun Zhang
Lycopodii herba (SJC), a traditional Chinese medicine, has the effect of dispelling wind and eliminating dampness (a therapeutic principle and method of traditional Chinese medicine for rheumatoid arthritis), relaxing tendon and activating collaterals. However, the major effective components and its therapeutic mechanism were unclear. In this study, different SJC samples with slightly different compositions
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FGF21 Enhances Therapeutic Efficacy and Reduces Side Effects of Dexamethasone in Treatment of Rheumatoid Arthritis Inflammation (IF 3.212) Pub Date : 2020-10-24 Xu Sun, Yin-zhuo Xie, Yuan-yuan Jiang, Guan-ying Wang, Yu-jia Wang, Yu Mei, Rong-hui Gao, Yan-hua Li, Wei Xiao, Wen-fei Wang, De-shan Li
In order to investigate efficacy of FGF21 combine dexamethasone (Dex) on rheumatoid arthritis (RA) meanwhile reduce side effects of dexamethasone. We used combination therapy (Dex 15 mg/kg + FGF21 0.25 mg/kg, Dex 15 mg/kg + FGF21 0.5 mg/kg or Dex 15 mg/kg + FGF21 1 mg/kg) and monotherapy (Dex 15 mg/kg or FGF21 1 mg/kg) to treat CIA mice induced by chicken type II collagen, respectively. The effects
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Surfactant Attenuates Air Embolism-Induced Lung Injury by Suppressing NKCC1 Expression and NF-κB Activation Inflammation (IF 3.212) Pub Date : 2020-10-22 Chou-Chin Lan, Yao-Kuang Wu, Chung-Kan Peng, Kun-Lun Huang, Chin-Pyng Wu
Excessive amounts of air can enter the lungs and cause air embolism (AE)-induced acute lung injury (ALI). Pulmonary AE can occur during diving, aviation, and iatrogenic invasive procedures. AE-induced lung injury presents with severe hypoxia, pulmonary hypertension, microvascular hyper-permeability, and severe inflammatory responses. Pulmonary AE-induced ALI is a serious complication resulting in significant
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Toll-like Receptor 4 Inhibitor TAK-242 Improves Fulminant Hepatitis by Regulating Accumulation of Myeloid-Derived Suppressor Cell Inflammation (IF 3.212) Pub Date : 2020-10-20 Haiyan Wang, Xuehui Li, Guanjun Dong, Fenglian Yan, Junfeng Zhang, Hui Shi, Zhaochen Ning, Min Gao, Dalei Cheng, Qun Ma, Changying Wang, Mingsheng Zhao, Jun Dai, Chunxia Li, Zhihua Li, Hui Zhang, Huabao Xiong
Fulminant hepatitis (FH) is an acute clinical disease with a poor prognosis and high mortality rate. The purpose of this study was to determine the protective effect of the Toll-like receptor 4 (TLR4) inhibitor TAK-242 on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced explosive hepatitis and explore in vivo and in vitro mechanisms. Mice were pretreated with TAK-242 for 3 h prior to LPS (10 μg/kg)/D-GalN
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Down–regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1 Inflammation (IF 3.212) Pub Date : 2020-10-16 Yujuan Qi, Kai Zhang, Peijun Li, Zhenhua Wu
Downregulating miR-217-5p could protect cardiomyocytes against ischemia/reperfusion (I/R) injury, but its role in restoring mitochondrial function of I/R-injured cardiomyocytes remained unclear. H9C2 cardiomyocyte-derived cell line with I/R injury was established in vitro on the basis of hypoxia/reperfusion (H/R) model. Cell viability and apoptosis were respectively detected by MTT assay and flow cytometry
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CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease Inflammation (IF 3.212) Pub Date : 2020-10-16 Qicai Liu, Yunfeng Lin, Sheng Zhang, Min Chen, Qingquan Chen, Hongbin Rui, Fang Wang, Xiaoting Lv, Feng Gao
Similar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, it was confirmed that MAG (myelin-associated glycoprotein) antibodies (IgG, IgG4, and IgM) were detected by immunofluorescence (IFA) in serum of the patients with IgG4-RD. In vivo, the levels of
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Heparin-Binding Protein Enhances NF-κB Pathway-Mediated Inflammatory Gene Transcription in M1 Macrophages via Lactate Inflammation (IF 3.212) Pub Date : 2020-10-14 Zhongqian Lu, Xing Li, Peng Yang, Genhua Mu, Lei He, Chunmei Song, Feng Xu
In early-stage sepsis, glucose metabolism is increased primarily through glycolysis in the inflammatory response of M1 macrophages. Heparin-binding protein (HBP) has been linked to sepsis, which can promote macrophage activation and inflammatory factor release. However, the mechanism by which glucose metabolism regulates the inflammatory response is unclear. We show that HBP contributes to sepsis by
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Retraction Note: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model Inflammation (IF 3.212) Pub Date : 2020-10-12 Sachin S. Sakat, Kamaraj Mani, Yulia O. Demidchenko, Evgeniy A. Gorbunov, Sergey A. Tarasov, Archna Mathur, Oleg I. Epstein
The Editor has retracted this article [1] because there are concerns about the scientific validity of the study and undeclared conflicts of interest.
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Interleukin-1β Protection Against Experimental Sepsis in Mice Inflammation (IF 3.212) Pub Date : 2020-10-12 Hai-lei Guo, Fu-dong Shi, Qi Zhou, Qing-yang Liu, Yue-xin Wang, Yang Song, Zong-sheng Wu, Yu-hao Shi, Liu Zhang, Kai-zhi Xu, Guo-dong Song
The inflammatory response involving interleukin-1β (IL-1β) has been thought to play an important role in the development of late-phase sepsis. However, in this study, we wanted to explore the possibility of using IL-1β to improve the prognosis of sepsis by triggering local differentiation of bone marrow cells (BMCs) into regulatory dendritic cells (DCs) in vivo, thereby reversing the immune paralysis
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Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis Inflammation (IF 3.212) Pub Date : 2020-10-10 Haruei Ogino, Keita Fukaura, Yoichiro Iboshi, Yousuke Nagamatsu, Hiroaki Okuno, Kei Nishioka, Yuichiro Nishihara, Yoshimasa Tanaka, Takatoshi Chinen, Eikich Ihara, Yoshihiro Ogawa
Ulcerative colitis (UC) has been considered a Th2- and Th17-related disease. However, anti-IL-12/23 p40 antibody, which blocks Th1 and Th17 cell induction and maintenance, has shown efficacy in treating UC, suggesting that UC might not be a prototypical Th2 and Th17 cell-mediated autoimmune disease. To verify how the immune responses in UC patients interact with each other, we analyzed the cytokine
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Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases Inflammation (IF 3.212) Pub Date : 2020-10-10 Xianzheng Zhang, Dan Mei, Lingling Zhang, Wei Wei
There are more than 80 kinds of autoimmune diseases known at present, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), inflammatory bowel disease (IBD), as well as other disorders. Autoimmune diseases have a characteristic of immune responses directly attacking own tissues, leading to systematic inflammation and subsequent tissue damage. B cells play
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Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice Inflammation (IF 3.212) Pub Date : 2020-10-09 Karina Scheuermann, Laura Alejandra Ariza Orellano, Celso Tarso Rodrigues Viana, Clara Tolentino Machado, Marcela Guimarães Takahashi Lazari, Luciano Santos Aggum Capettini, Silvia Passos Andrade, Paula Peixoto Campos
Recent data has signaled that in addition to its therapeutic indications as antidepressant and analgesic, amitriptyline (AM) exerts anti-inflammatory effects in humans and experimental animal models of acute inflammation. We tested the hypothesis that this compound could also modulate the chronic inflammatory process induced by synthetic matrix in mice. Polyether-polyurethane sponge disks were implanted
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Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications Inflammation (IF 3.212) Pub Date : 2020-10-08 Masae Iwasaki, Junichi Saito, Hailin Zhao, Atsuhiro Sakamoto, Kazuyoshi Hirota, Daqing Ma
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) as a functional “receptor” and then enters into host cells to replicate and damage host cells and organs. ACE2 plays a pivotal role in the inflammation, and its downregulation
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Dimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis Inflammation (IF 3.212) Pub Date : 2020-10-07 Sheng Zhang, Yalou Jiao, Chao Li, Xiao Liang, Huiqin Jia, Zhelong Nie, Yanwei Zhang
Sepsis is an inflammatory disease characterized by dysregulation of inflammation. Macrophage-mediated inflammation has been implicated in the pathophysiology of sepsis. Itaconate is a metabolite produced in activated macrophages which has anti-inflammatory activities. In the present study, we investigated the potential effects of a cell-permeable itaconate derivative dimethyl itaconate on inflammation
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Correction to: Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway Inflammation (IF 3.212) Pub Date : 2020-10-07 Xinxin Liu, Ji Li, Xiaohong Peng, Bo Lv, Peng Wang, Xiaoming Zhao, Bo Yu
After publication of our article [1], we found that the second images in the first row in Figure 2a were inadvertently replaced with the first image in Figure 2a.
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Gefitinib-Induced Cutaneous Toxicities in Brown Norway Rats Are Associated with Macrophage Infiltration Inflammation (IF 3.212) Pub Date : 2020-10-06 Liangqin Wan, Yalei Wang, Yibo Tang, Yan Tan, Fang He, Yali Zhang, Ke Yang, Ziwei Chen, Chenchen Song, Ruoxi Gu, Ce Zhang, Xu Wang, Peng Wei, Tonghua Liu, Miao Jiang, Qian Hua
Gefitinib (Iressa), is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), used in the targeted treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). Skin toxicity is the major adverse effect observed in patients treated with EGFR-targeted TKIs such as gefitinib and erlotinib. To date, a corresponding skin animal model has not been established
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Luteolin Relieved DSS-Induced Colitis in Mice via HMGB1-TLR-NF-κB Signaling Pathway Inflammation (IF 3.212) Pub Date : 2020-10-05 Ting Zuo, Yinzi Yue, Xiaohui Wang, Huan Li, Shuai Yan
The aim of this study was to investigate the effect of luteolin (Lu) on dextran sodium sulfate (DSS)–induced colitis in mice. Mice spleen was weighed. The length of colon was measured. H&E staining was used to observe the pathological changes of colon in mice. Superoxide dismutase (SOD) and malondialdehyde (MDA) in serum and intestine of mice were detected by commercial kits. Serum and intestinal cytokines
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GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells Inflammation (IF 3.212) Pub Date : 2020-10-03 Deyuan Zhi, Meng Zhang, Jin Lin, Pei Liu, Meili Duan
Acute kidney injury (AKI) is the most common complication of sepsis with a high mortality rate. In this study, we focus on the renal injury caused by the immune response of renal tubular epithelial cells and inflammation-induced renal tubular epithelial cell apoptosis. We studied the role of GRP120 in the inflammation and apoptosis of human renal cell line HK-2 and mouse primary renal tubular epithelial
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Pterostilbene Exerts Hepatoprotective Effects through Ameliorating LPS/D-Gal-Induced Acute Liver Injury in Mice Inflammation (IF 3.212) Pub Date : 2020-10-02 Ziyi Liu, Jingjing Wang, Yong Zhang, Di Wu, Shuangqiu Li, Aimin Jiang, ChongTao Du, Guanghong Xie
Acute liver injury (ALI) refers to abnormalities in liver function caused by various causes and accompanied by poor prognosis and high mortality. Common predisposing factors for the disease are viral hepatitis, bacteria, alcohol, and certain hepatotoxic drugs. Inflammatory response and oxidative stress are critical for the pathogenesis of ALI. Pterostilbene (Pte), a natural polyphenol product extracted
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Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage. Inflammation (IF 3.212) Pub Date : 2020-09-25 Yehudit Shabat,Yoav Lichtenstein,Yaron Ilan
Cohousing of sick with healthy or treated animals is based on the concept of sharing an intestinal ecosystem and coprophagy, the consumption of feces, which includes sharing of the microbiome and of active drug metabolites secreted in the feces or urine. To develop a model for short-term cohousing, enabling the study of the effect of sharing an ecosystem on inflammatory states. To determine the impact
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The Combinatorial Effect of Acetate and Propionate on High-Fat Diet Induced Diabetic Inflammation or Metaflammation and T Cell Polarization. Inflammation (IF 3.212) Pub Date : 2020-09-25 Dipeeka K Mandaliya,Sweta Patel,Sriram Seshadri
High-fat diet (HFD) alters the gut microbiota and its fermentation products mainly acetate, propionate, and butyrate. Butyrate is well studied as a regulator of host metabolism and inflammation while acetate and propionate still need to be studied. Therefore, we aim to decipher the role of acetate and propionate alone and in combination in HFD-induced diabetic mice. HFD was given to mice for 4 months
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Substance P Mediates Estrogen Modulation Proinflammatory Cytokines Release in Intervertebral Disc. Inflammation (IF 3.212) Pub Date : 2020-09-23 Xiao-Xing Song,Lin-Yu Jin,Xin-Feng Li,Yan Luo,Bu-Wei Yu
Intervertebral disc degeneration (IDD) is a main contributor to low back pain. A close relationship exists between inflammation and pain. Estrogen can affect inflammation and may play a crucial role in IDD and pain. Substance P (SP) can also regulate the expression of pro-inflammatory cytokines in intervertebral disc (IVD). This study aimed to investigate the potential role of SP in estrogen regulation
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Integrative Analysis of MicroRNAs and mRNAs in LPS-Induced Macrophage Inflammation Based on Adipose Tissue Stem Cell Therapy. Inflammation (IF 3.212) Pub Date : 2020-09-21 Xiaozhi Bai,Ting He,Mingchuan Liu,Lincheng Li,Jie Chen,Mengyuan Cao,Yang Liu,Chen Yang,Wenbin Jia,Ke Tao,Juntao Han,Dahai Hu
Severe inflammation can lead to multiple organ dysfunction syndrome, which has high mortality. Adipose-derived stem cells have been shown to affect the inflammatory response of macrophages. However, the molecular mechanism of the anti-inflammatory capacity of adipose-derived stem cells (ADSCs) remains to be understood. In the present study, a macrophage inflammation model was established by LPS, and
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Focus on the Multimodal Role of Autophagy in Rheumatoid Arthritis. Inflammation (IF 3.212) Pub Date : 2020-09-21 Swati Chadha,Tapan Behl,Simona Bungau,Arun Kumar,Rajwinder Kaur,Thangaval Venkatachalam,Amit Gupta,Mimansa Kandhwal,Deepak Chandel
Autophagy exerts its dual role in eukaryotic cells and exerts its cytoprotective action through degradation mechanism and by regulating catabolic processes which results in elimination of pathogens. Under suitable conditions, autophagy is associated with recycling of cytoplasmic components which causes regeneration of energy whereas deregulated autophagy exerts its implicated role in development and
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GLP-1R Agonist Liraglutide Attenuates Inflammatory Reaction and Neuronal Apoptosis and Reduces Early Brain Injury After Subarachnoid Hemorrhage in Rats. Inflammation (IF 3.212) Pub Date : 2020-09-19 Xian-Kun Tu,Quan Chen,Song Chen,Bin Huang,Bao-Gang Ren,Song-Sheng Shi
Liraglutide, one of the glucagon-like peptide 1 receptor (GLP-1R) agonists, has been demonstrated to protect brain damage produced by ischemic stroke. However, it remains unknown whether liraglutide attenuates early brain injury after subarachnoid hemorrhage. The present study was performed to explore the effect of liraglutide on early brain injury after subarachnoid hemorrhage in rats, and further
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Rosmarinic Acid Regulates Microglial M1/M2 Polarization via the PDPK1/Akt/HIF Pathway Under Conditions of Neuroinflammation. Inflammation (IF 3.212) Pub Date : 2020-09-17 Yicong Wei,Jianxiong Chen,Guo-En Cai,Wei Lu,Wei Xu,Ruiguo Wang,Yu Lin,Chengzi Yang
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Amorphous Calcium Phosphate NPs Mediate the Macrophage Response and Modulate BMSC Osteogenesis. Inflammation (IF 3.212) Pub Date : 2020-09-16 Liangjiao Chen,Pengyan Qiao,Hongchen Liu,Longquan Shao
The potential risk associated with ACP nanoparticles (ACP NPs) cultured with immune cells and their indirect effects on osteogenesis have not been studied deeply. This project aims to evaluate the safety of ACP NPs in macrophages, the responses of macrophages (macrophage polarization, the cytokine secretion pattern of macrophages and intracellular homeostasis) to ACP NPs and the effect of ACP NPs/
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Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation. Inflammation (IF 3.212) Pub Date : 2020-09-16 Yu Sugimoto,Daiki Endo,Yasuaki Aratani
Patients with chronic granulomatous disease (CGD) who have mutated phagocyte NADPH oxidase are susceptible to infections due to reduced reactive oxygen species production and exhibit autoimmune and inflammatory diseases in the absence of evident infection. Neutrophils and macrophages have been extensively studied since phagocyte NADPH oxidase is mainly found only in them, while the impact of its deficiency
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ROS-Dependent Lipid Peroxidation and Reliant Antioxidant Ferroptosis-Suppressor-Protein 1 in Rheumatoid Arthritis: a Covert Clue for Potential Therapy. Inflammation (IF 3.212) Pub Date : 2020-09-12 Zhaoxiang Xie,Haodong Hou,Dan Luo,Ran An,Yunpeng Zhao,Cheng Qiu
Rheumatoid arthritis (RA) is a common systemic autoimmune disease with a prevalence of about 1% in which genetic and environmental risk factors both participate in performance of disease. Though several studies contributed in identifying its etiology and pathogenesis, the underlying mechanisms are still unknown. To date, so as palliative for RA, cure strategies are still popular. Hypoxia and oxidative
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S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice. Inflammation (IF 3.212) Pub Date : 2020-09-12 Yan-Ling Liao,Xiao-Yan Zhou,Mu-Huo Ji,Liang-Cheng Qiu,Xiao-Hui Chen,Can-Sheng Gong,Ying Lin,Yan-Hua Guo,Jian-Jun Yang
Sepsis-associated encephalopathy (SAE) is a clinical syndrome of brain dysfunction secondary to sepsis, which is characterized by long-term neurocognitive deficits such as memory, attention, and executive dysfunction. However, the mechanisms underlying SAE remain unclear. By using transcriptome sequencing approach, we showed that hippocampal S100A9 was significantly increased in sepsis induced by cecal
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Effects of Lactobacillus casei Strain T2 (IBRC-M10783) on the Modulation of Th17/Treg and Evaluation of miR-155, miR-25, and IDO-1 Expression in a Cuprizone-Induced C57BL/6 Mouse Model of Demyelination. Inflammation (IF 3.212) Pub Date : 2020-09-10 Saeideh Gharehkhani Digehsara,Niloofar Name,Behnaz Esfandiari,Elahe Karim,Saba Taheri,Maryam Tajabadi-Ebrahimi,Javad Arasteh
Multiple sclerosis (MS) is a complex inflammatory disease in which demyelination occurs in the central nervous system affecting approximately 2.5 million people worldwide. Recent reports have shown that the gut microbiome plays a crucial role in the functioning of the immune system in inflammatory diseases such as MS. In this study, the cuprizone-induced demyelination mouse model was used to investigate
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Anti-inflammatory and In Silico Docking Studies of Heterophragma adenophyllum Seem Stem Constituents. Inflammation (IF 3.212) Pub Date : 2020-09-08 Tareq Abu-Izneid,Zafar Ali Shah,Abdur Rauf,Abdul Wadood,Saud Bawazeer,Naveed Muhammad,Mohamed A El-Esawi,Fahad A Alhumaydhi,Abdullah S M Aljohani,Eman El-Sharkawy,Mohammad S Mubarak,Kuralay Isayeva,Mohammad Ali Shariati
Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory effect using the carrageenan- and histamine-induced paw edema paradigm. The tested
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Effect of Exclusive Enteral Nutrition on Th17 Cells in Juvenile Rats with Inflammatory Bowel Disease. Inflammation (IF 3.212) Pub Date : 2020-09-08 Xu Teng,Yingying Qi,Jing Li,Jie Wu
The objective was to investigate the effect of exclusive enteral nutrition (EEN) on T helper (Th) 17 cells by observing the effects of EEN on colon and serum interleukin (IL)-17A levels in juvenile inflammatory bowel disease (IBD) rat models and to reveal the potential mechanism of the therapeutic effect of EEN on IBD. ATNBS-induced IBD rat model was established. Feeding Peptison, a type of enteric
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miR-30c-5p Alleviated Pyroptosis During Sepsis-Induced Acute Kidney Injury via Targeting TXNIP. Inflammation (IF 3.212) Pub Date : 2020-09-05 Xiang Li,Linya Yao,Xueming Zeng,Bing Hu,Xi Zhang,Jun Wang,Runyu Zhu,Qiwei Yu
Sepsis-induced acute kidney injury (SAKI) is a common complication of hospitalized patients, often leading to unacceptable mortality. Limited effective treatment or diagnosis biomarkers are available and the underlying mechanism remains unclear. The miR-30c-5p is considered as a critical mediator of kidney diseases and aberrantly decreased in patients with SAKI, while the mechanism is still unclear
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Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease. Inflammation (IF 3.212) Pub Date : 2020-09-04 John Audley,Emily F Gliniewicz,Kol A Zarember,Hanna S Hong,Gal Wald,Douglas B Kuhns,Elizabeth Kang,Harry L Malech,Anthony F Suffredini,Robert J Noveck,Mark J Dinubile,Susan L Levinson,Thomas P Stossel,John I Gallin
Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies demonstrate reduced pGSN concentrations in several disease states, including severe trauma, burns, and sepsis. Markedly decreased pGSN concentrations in these conditions precede and predict adverse clinical outcomes. In this study, we measured pGSN
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MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway. Inflammation (IF 3.212) Pub Date : 2020-09-02 Palani Dinesh,Sowmiya Kalaiselvan,Sali Sujitha,Mahaboobkhan Rasool
Inflammation is a complex biological process which alters the normal physiological function of the immune system resulting in an abnormal microenvironment that leads to several clinical complications. The process of inflammation is mediated through various intracellular signaling factors inside the cells. Apoptosis signal–regulating kinase 1 (ASK1) is an inflammation-derived kinase that controls the
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Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1. Inflammation (IF 3.212) Pub Date : 2020-09-01 L C M Coelho,J V Cruz,I K Maba,Aleksander Roberto Zampronio
Sex differences in the immune response can also affect the febrile response, particularly the fever induced by lipopolysaccharide (LPS). However, other pathogen-associated molecular patterns, such as zymosan A (Zym) and polyinosinic-polycytidylic acid (Poly I:C), also induce fever in male rats with a different time course of cytokine release and different mediators such as endothelin-1 (ET-1). This