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Are skin tests useful after benign immediate reactions to beta-lactams in children? Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-18 Bouchra Mahjoub, Charlotte Marsac, Claude Ponvert, Christophe Delacourt, Hassan Faour, Nicolas Garcelon, Guillaume Lezmi
Summary box Benign immediate reactions to beta-lactams in children are at low risk of hypersensitivity. Such reactions could be explored by direct drug provocation tests.
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Asthma outcomes, inhaled corticosteroid adherence and socio-economic deprivation in English regions Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-17 Haania Hussain, Tricia M. McKeever, Sherif Gonem
Summary box Socio-economic deprivation is strongly associated with poor asthma outcomes in England. This relationship does not appear to be primarily mediated by poor adherence to inhaled corticosteroids.
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Adherence to adrenaline autoinjector prescriptions in patients with severe food allergy Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-16 Sebastian Vigand Svendsen, Annemarie Schaeffer Senders, Athamaica Ruiz Oropeza, Annmarie Lassen, Henrik Fomsgaard Kjaer, Carsten Bindslev‐Jensen, Charlotte G. Mortz
Summary box Sixty-four per cent of peanut or hazelnut allergic patients who required adrenaline autoinjectors adhered to their prescriptions. Adherence to prescriptions was highest among females and young children and significantly lower among adolescents.
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Adverse drug reactions from adrenaline auto‐injectors: Data from the French poison control centres Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-16 Guillaume Pouessel, Christine Tournoud, Sophie Gautier, Patrick Nisse, Luciana Kase Tanno
Summary box Most adrenaline auto-injector-related adverse drug reactions are of mild severity, avoidable, after accidental injections. Adrenaline injected by subcutaneous/intramuscular routes is well-tolerated, even out of the context of anaphylaxis.
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Component‐specific clusters for diagnosis and prediction of allergic airway diseases Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-13 Rebecca Howard, Sara Fontanella, Angela Simpson, Clare S. Murray, Adnan Custovic, Magnus Rattray
BackgroundPrevious studies which applied machine learning on multiplex component‐resolved diagnostics arrays identified clusters of allergen components which are biologically plausible and reflect the sources of allergenic proteins and their structural homogeneity. Sensitization to different clusters is associated with different clinical outcomes.ObjectiveTo investigate whether within different allergen
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Phosphoinositide‐3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-12 Anurag Bhalla, Katherine Radford, Kiho Son, Kayla Zhang, Chynna Huang, Melanie Kjarsgaard, Nicola LaVigne, Zachary Brautigam, Sarah Svenningsen, Guillaume Paré, Manali Mukherjee, Parameswaran Nair
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Association between long‐term occupational exposure to PM10 and allergic diseases in subway workers Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-12 Romain Freund, Jean‐Jacques Sauvain, Guillaume Suarez, Pascal Wild, Thomas Charreau, Jacques A. Pralong, Amélie Debatisse, Valérie Jouannique, Kirushanthi Sakthithasan, Irina Guseva Canu
Summary box In locomotive operators, subway PM10 exposure is associated with asthma prevalence. Nitrite in exhaled breath condensate is associated with prevalent allergic diseases.
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Risk factors for sulfamethoxazole/trimethoprim‐induced severe cutaneous adverse reactions Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-11 Kanokkarn Pinyopornpanish, Apinya Chungcharoenpanich, Putthapon Teepapan, Kunlawat Thadanipon, Chulapha Ruangwattanachok, Pansa Lamrahong, Nattakirana Thongdee, Nizchapa Dechapaphapitak, Chonlaphat Sukasem, Chanamon Pongphaew, Thawinee Jantararoungtong, Napatrupron Koomdee, Wannada Laisuan
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BabyBathe study protocol: A randomised controlled feasibility trial to change baby bathing practice during the first months of life Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-11 Michael R. Perkin, Michael Ussher, Lucy P. Goldsmith, Carsten Flohr, Amanda Roberts, Victoria Cornelius, Charlotte Wahlich, Kathryn Willis, Robert J. Boyle
Summary box To work with pregnant women to develop an acceptable intervention to reduce infant bathing frequency To undertake a randomised controlled feasibility trial to estimate the proportion of eligible families willing to be randomised to the intervention, their adherence to the intervention and its acceptability
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Correction to ‘Eosinophil‐derived neurotoxin levels in early childhood and association with preschool asthma—A prospective observational study’ Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-08
Färdig M, Lie A, Borres MP, et al. Eosinophil-derived neurotoxin levels in early childhood and association with preschool asthma—A prospective observational study. Clin Exp Allergy. 2023;53:1198-1211. doi:10.1111/cea.14409 In the list of authors, one of the co-author's surname is missing. The correct name is ‘Anne Cathrine Staff’. It has been corrected in the online version. We apologize for this error
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Factors associated with venom immunotherapy side‐effects, re‐sting reactions, and adherence in real‐life Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-03-08 Louise Parke, Henrik Fomsgaard Kjaer, Susanne Halken, Carsten Bindslev‐Jensen, Charlotte G. Mortz
Summary box VIT side effects are associated with female sex, honeybee venom, and severity of initial sting reaction. Re-sting reactions after completed VIT are associated with side effects during VIT. To the Editor, A single Hymenoptera sting can potentially be fatal. Venom immunotherapy (VIT) is an effective and disease-modifying treatment for IgE-mediated venom allergy and the only approved treatment
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Optimising the management of peanut allergy by targeting immune plasticity Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-29 Alan Nguyen, George du Toit, Gideon Lack, Tom Marrs
Randomised controlled trials investigating the efficacy of oral tolerance induction to peanut have enabled detailed comparison of their clinical and immunological success. They have demonstrated that the regular consumption of peanut for at least 2 years by babies who are not allergic enables protection from developing peanut allergy. The LEAP study intervention tested the impact of regular peanut
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Allergy in China: Challenges in research, training and clinical practice Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-28 Zheng Liu, Xu Yao, Yin Yao, Xiaochun Liu, Gary W. K. Wong
Allergic disorders have become some of the most common chronic conditions affecting people in the developed world. There is clear evidence linking economic development, urbanization and an increase in the prevalence of allergic disorders. Over the past 30 years, the pace of urbanization in China has been extraordinary and associated with rapid rise in the prevalence of allergic disorders. Notably,
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The Ukrainian Milk Ladder: Enhancing diet for children with cow's milk allergy Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-21 Vladyslava Barzylovych, Tetiana Umanets, Anastasiia Barzylovych, Hanna Hilenko, Viktoria Stelmah, Lesya Besh, Svetlana Nedelskaya, Oleksandr Abaturov, Volodymyr Ditiatkovsky, Hanna Kasianenko, Viktoriia Khomenko, Volodymyr Lapshyn, Yurii Antipkin
Key messages Milk ladders are widely used by healthcare professionals and caregivers of children with CMA. Ukrainian Milk Ladder is a milk ladder adapted to suit Ukrainian cuisine.
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Patient-reported outcomes in food allergy: Speaking the same language to address some of the GAPS Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-14 Jennifer L. P. Protudjer, Helen Brough, Christina J. Jones, Mary Jane Marchisotto, Linda J. Herbert, Caity Roleston, Rebecca C. Knibb
Key messages Patients' voices are critical for comprehensive allergy management, yet non-English-speaking groups are often underrepresented. We designed a method to amplify the multilingual voices of those living with food allergies.
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Comparative effectiveness and tolerability of dual and triple combination inhaler therapies for adolescents and adults with asthma Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-14 Fares Dashti, Ian Gregory
Key Messages High-dose triple combination therapy may provide some benefit in the management of poorly controlled asthma. Side effects of long-term high-dose triple combination therapy remain poorly defined. High-dose triple combination therapy can be useful in selecting patients while awaiting specialist assessment.
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Biomarkers predicting the controller dose of omalizumab in patients with chronic spontaneous urticaria Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-11 L. Zubiaga-Fernandez, A. Testera-Montes, C. Rondon, N. Perez-Sanchez, F. Gomez-Perez, J. M. Vega-Chicote, J. Bartra, M. Ferrer, I. Eguiluz-Gracia, M. J. Torres
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Ocular surface disease in moderate-to-severe atopic dermatitis patients and the effect of biological therapy Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-08 Roselie Achten, Judith Thijs, Marlot van der Wal, Chantal van Luijk, Daphne Bakker, Edward Knol, Matthijs van Luin, Mohsin El Amrani, Eveline Delemarre, Ahmed M I Elfiky, Joke de Boer, Femke van Wijk, Marlies de Graaf, Marjolein de Bruin-Weller
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B cell immune response to human bocaviruses Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-06 Cagatay Karaaslan, Oliver Wirz, Ge Tan, Anna Globinska, Tadech Boonpiyathad, Klaus Hedman, Slavica Vaselek, Maria Söderlund Venermo, Tuomas Jartti, Mubeccel Akdis, Cezmi A. Akdis
Human bocaviruses (HBoVs) have been demonstrated in respiratory and gastrointestinal infections; however, the immune response to them has not been studied in detail. In this study, we investigated the B cell immune responses to HBoV1 and HBoV2, representing two different species of bocaviruses in humans.
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Effects of air purifiers on rhinitis quality of life and perception of sleep quality in people with asthma: Randomised controlled trial Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-05 Latha Kadalayil, Scott Lowther, Wei Chern Gavin Fong, Frédéric Nicolas, Stephen Potter, Maria Larsson, Ramesh Kurukulaaratchy, Syed Hasan Arshad
Key messages Dyson air purifier with HEPA filter improves indoor air quality by reducing PM2.5 particles. Post hoc analysis of rhinitis-specific quality of life and sleep quality of asthma patients indicated improvement.
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Associations between gender and health-related quality of life in people with IgE-mediated food allergy and their caregivers: A systematic review Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-02-07 Sophie A. Rosser, Melanie Lloyd, Alice Hu, Paxton Loke, Mimi L. K. Tang
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Plant-produced Der p 2-bearing bioparticles activate Th1/Treg-related activation patterns in dendritic cells irrespective of the allergic background Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-27 Stefanie Busold, Lorenz Aglas, Charlotte Menage, Réjean Desgagnés, Loïc Faye, Anne-Catherine Fitchette, Esther C. de Jong, Caroline Martel, Maria Stigler, Virginie Catala-Stordeur, Guy Tropper, Lydia Auger, Bertrand Morel, Serge A. Versteeg, Louis-P Vézina, Véronique Gomord, Janice A. Layhadi, Mohamed Shamji, Teunis B. H. Geijtenbeek, Ronald van Ree
Key points Der p 2-harbouring bioparticles are hypoallergenic. Der p 2-harbouring bioparticles induce immunomodulatory signatures on dendritic cells that are largely unaffected by allergic status. To the Editor, Allergen immunotherapy (AIT) is the only disease-modifying treatment for allergic diseases with proven sustained efficacy, but long treatment duration, chronic exposure to aluminium salts and
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Salivary IL-8 and sTREM-1 in chronic urticaria: A diagnostic test accuracy study Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-25 Witness Dzobo, Efrem Eren, Samuel Robson, Janis K. Shute
Key points CombiROC analysis indicated salivary interleukin-8 (IL-8) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) may be good diagnostic biomarkers of omalizumab-untreated CU. Salivary sTREM-1, but not IL-8, levels may be indicative of response to omalizumab therapy.
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Protein–Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-22 Annette T. Hastie, Andrew C. Bishop, Mohammad S. Khan, Eugene R. Bleecker, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Wendy C. Moore, Victor E. Ortega, Stephen P. Peters, Sally E. Wenzel, Chad H. Steele
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Allergy testing in lower middle income countries Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-17 Neeraj Gupta, Kassim Babu Mapondela
Lower-middle-income countries (LMICs) are home to nearly 3.2 billion people, approximately 40% of the world's population. India, currently the most populous country, is home to over 1.4 billion people. Allergic problems contribute to the overall health challenges in LMICs. According to the Global Burden of Disease study, asthma alone was responsible for the loss of 21.6 million disability-adjusted
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Risk subgroups and intervention effects among infants at high risk for peanut allergy: A model for clinical decision making Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-19 Yuxiang Li, Ashley Devonshire, Bin Huang, Sandra Andorf
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Safe selection of children with a suspected food allergy to introduce peanut or tree nuts at home Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-19 W. W. de Weger, C. E. M. Herpertz, G. N. van der Meulen, H. Bangma, W. Kastelijn, L. van Lente, G. H. Koppelman, A. B. Sprikkelman, A. W. A. Kamps
Summary box Selection tool (algorithm) for safe introduction of food at home in suspected food-allergic children. Home introduction of peanut/tree nuts in children selected through this tool is feasible and safe.
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Protective effects of allergic diseases in COVID-19 outcomes: A retrospective cohort study in UK Biobank in the general population and in patients with cancer Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-16 Aida Santaolalla, Heather J. Bax, Jitesh Chauhan, Debra H. Josephs, Mieke Van Hemelrijck, Sophia N. Karagiannis
To the Editor, SARS-CoV-2 (COVID-19) infection can lead to acute respiratory distress syndrome (ARDS) in severe cases. Preliminary evidence during the COVID-19 pandemic suggested that respiratory diseases could be associated with poorer outcomes.1, 2 Th2 conditions, namely lower Th1/Th2 ratios and eosinophilia in allergic diseases, including allergic asthma, could mount an impaired immune response
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IgE to cross-reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-17 Ekaterina Potapova, Salvatore Tripodi, Valentina Panetta, Stephanie Dramburg, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Viviana Moschese, Ifigenia Sfika, Elena Varin, Riccardo Asero, Annamaria Bianchi,
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Easy assessment of the avidity of polyclonal allergen-specific serum antibodies Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-06 Maria R. Strobl, Hilal Demir, Gordana Wozniak-Knopp, Andrea Wangorsch, Florian Rüker, Barbara Bohle
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Urticaria and angioedema in Estonia, Iceland and Sweden Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-08 Johanna Heldin, Andrei Malinovschi, Shadi Amid Hägg, Thorarinn Gíslason, Bryndís Benediktsdóttir, Robert Movérare, Jenny Hallgren, Magnus Molin, Rain Jogi, Christer Janson
Summary box One in four and one in ten have had urticaria and angioedema, with considerable overlap. Those with urticaria and angioedema urticaria had lower quality of sleep and physical health status.
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Cochrane corner: Skin care interventions in infants for preventing eczema and food allergy Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-05 Alisha Burman, Nabeela Bhaloo
CONFLICT OF INTEREST STATEMENT Dr Bhaloo and Dr Burman have no conflicts of interest to declare.
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Glycolysis: An early marker for vancomycin-specific T-cell activation Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-04 Joshua Gardner, Sean Hammond, Rebecca Jensen, Andrew Gibson, Matthew S. Krantz, Michael Ardern-Jones, Elizabeth J. Phillips, Munir Pirmohamed, Amy E. Chadwick, Catherine Betts, Dean J. Naisbitt
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Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-02 Guillaume Pouessel, Charles Tacquard, Luciana Kase Tanno, Paul Michel Mertes, Guillaume Lezmi
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Evaluation of measurement errors in the Patient-Oriented Eczema Measure (POEM) outcome Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-02 Ariane Duverdier, Guillem Hurault, Kim S. Thomas, Adnan Custovic, Reiko J. Tanaka
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Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-02 Cristina Gamez, Jonatan Leffler, Sharon Clark, Karli Corscadden, Susan L. Prescott, Debra J. Palmer, Deborah Strickland
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Design of an Ara h 2 hypoallergen from conformational epitopes Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-02 Jungki Min, Tarun Keswani, Nicole A. LaHood, Isabelle R. Lytle, Orlee Marini-Rapoport, Léna Andrieux, Sunny L. Sneed, Lori L. Edwards, Robert M. Petrovich, Lalith Perera, Anna Pomés, Lars C. Pedersen, Sarita U. Patil, Geoffrey A. Mueller
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Peripheral blood mononuclear cell transcriptome profile in a clinical trial with subcutaneous, grass pollen allergoid immunotherapy Clin. Exp. Allergy (IF 6.1) Pub Date : 2024-01-02 Sviatlana Starchenka, Kemi Oluwayi, Matthew Heath, Oliver Armfield, Mohamed Shamji, Janice Layhadi, Katarzyna Lis, Lisa Cadavez, Olesya Rusyn, Murray Skinner, Pieter-Jan De Kam
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Differential dynamics of TARC during JAK-inhibitor therapy compared to biological therapies targeting type 2 inflammation Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-12-30 Celeste M. Boesjes, Daphne S. Bakker, Edward F. Knol, Marlies de Graaf, Femke van Wijk, Marjolein S. de Bruin-Weller
Key Messages Elevated TARC levels were found in AD patients treated with JAK inhibitors despite a good clinical response. The use of TARC as a clinical biomarker in these patients is therefore questionable.
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Long-term effects of pollen allergoid tyrosine-adsorbed subcutaneous immunotherapy on allergic rhinitis and asthma Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-12-26 Christian Vogelberg, Ludger Klimek, Silvia Kruppert, Sven Becker
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Prize-winning abstracts from the BSACI 2023 meeting Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-12-14 Mohamed H. Shamji, Robert J. Boyle, Graham Roberts
The annual British Society of Allergy and Clinical Immunology (BSACI) conference was held in Harrogate, York, UK, from 5 to 7 October 2023. This year, the Barry Kay Award, which recognises Professor Kay's national and international research contributions to the field of allergy and asthma and has inspired so many young Allergists and Chest Physicians, was awarded for the best abstracts in the Basic
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Celebrating 75 years of BSACI Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-12-14 Pamela W. Ewan, Stephen R. Durham, Glenis K. Scadding, Stephen T. Holgate
The British Association of Allergists (later named the British Allergy Society, then the British Society for Allergy and Clinical Immunology (BSACI)) was formed in 1948. Dr Vera Walker, an ophthalmologist, wrote to Dr John Freeman, St Mary's Hospital, London suggesting this. She became the new society's first president, and the first secretary was Dr William (Bill) Frankland. The first meeting had
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Drug allergy management in Egypt, Sri Lanka and the Caribbean: A qualitative study Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-12-11 Abdulaziz H. Alqahtani, Parbir Jagpal, Thushara Kudagammana, Pudupakkam K. Vedanthan, Kandamaran Krishnamurthy, Seetharaman Hariharan, Reham Mohamed El Shabrawy Mohamed Ali, Sandeep B. Maharaj, John F. Marriott, Mamidipudi Thirumala Krishna
Summary box Egypt, Sri Lanka, Barbados and Trinidad and Tobago lack equitable drug allergy management pathways. Computerised decision support systems alongside basic training and education might facilitate accurate labelling and de-labelling.
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Changes in sensitization rates for respiratory and food allergens by age. Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-30 Ji Ho Choi,Jeffrey D Suh,Intae Kim,Jin Kook Kim,Jae Hoon Cho
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Does CDHR3 gene polymorphism affect paediatric asthma and its treatment response? Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-28 Joana Carneiro,Roger Tavendale,Somnath Mukhopadhyay,Patrícia Soares
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Immunogenicity of cephalosporin components in non-IgE-mediated cephalosporin allergy. Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-27 Bodin Tuesuwan,Supranee Buranapraditkun,Weena Arjharn,Nithikan Suthumchai,Yuda Chongpison,Jettanong Klaewsongkram
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Role of epithelial barrier function in inducing type 2 immunity following early-life viral infection Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-27 Kunyuan Tian, Prakrati Dangarh, Haina Zhang, Christian L. Hines, Andrew Bush, Hannah J. Pybus, James A. Harker, Clare M. Lloyd, Reiko J. Tanaka, Sejal Saglani
Preschool wheeze attacks triggered by recurrent viral infections, including respiratory syncytial virus (RSV), are associated with an increased risk of childhood asthma. However, mechanisms that lead to asthma following early-life viral wheezing remain uncertain.
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Phenotypes of cough in children: A latent class analysis Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-23 Maria Christina Mallet, Eva S. L. Pedersen, Ronny Makhoul, Sylvain Blanchon, Karin Hoyler, Anja Jochmann, Philipp Latzin, Alexander Moeller, Nicolas Regamey, Myrofora Goutaki, Ben D. Spycher, Claudia E. Kuehni
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Tolerability of sublingual versus vestibular allergy immunotherapy tablet administration: A randomized pilot study Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-21 Marie-Lee Simard, Natalija Novak, Jean-Philippe Drolet, Marie-Claude Joly, Hendrik Nolte, Eike Wuestenberg, Rémi Gagnon
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The transient receptor potential vanilloid-3 (TRPV3) channel in epidermal keratinocytes induce thymic interstitial lymphopoietin: Implications for TRPV3-mediated itch pathways. Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-20 Ji Young Um,Han Bi Kim,Won-Sik Shim,Wook Joo Lee,So Yeon Lee,Jin Seo Park,Jin Cheol Kim,In Suk Kwak,Bo Young Chung,Chun Wook Park,Hye One Kim
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Multi-omic analysis of Tyrophagus putrescentiae reveals insights into the allergen complexity of storage mites Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-20 Angel Tsz-Yau Wan, Qing Xiong, Xiaojun Xiao, Kelvin Fu-Kiu Ao, Seok Woo Jang, Brian Shing-Hei Wong, Mingqiang Wang, Qin Cao, Cathy Sin-Hang Fung, Fook-Tim Chew, Baoqing Sun, Sai Ming Ngai, Ting-Fan Leung, Kyoung Yong Jeong, Xiaoyu Liu, Stephen Kwok-Wing Tsui
Summary Box A multi-omic analysis reveals the highly complex allergen profile of Tyrophagus putrescentiae. This comprehensive analysis of Tyrophagus putrescentiae can improve the component-resolved diagnosis of mite allergy.
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Association between allergic conditions and school absenteeism among Indian adolescents Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-20 Tina Qian, Andy Deprato, Smriti Debnath, Prasun Haldar, Dwiptirtha Chattopadhyay, Judith Garcia-Aymerich, Isabella Annesi-Maesano, Neel Patel, Paige Lacy, Saibal Moitra, Subhabrata Moitra
Summary Box Previous studies on allergic conditions and school absenteeism are limited and have only focused on asthma. Our research relating allergic conditions with school absenteeism highlight the much-undermined social burdens of allergic conditions.
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Management of childhood asthma and tools to evaluate asthma pathophysiology Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-14 Mohamed H. Shamji, Robert J. Boyle
Among the editors' choice studies in this month's issue are three exciting articles. The first, by Cristina Ardura-Garcia et al.,1 reports differences between children at risk of long-term suboptimal asthma control and those at risk of acute asthma attacks. The authors recommend that prediction tools and preventive efforts should differentiate these two asthma outcomes. The management of asthma in
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Eosinophil-derived neurotoxin reference values in asthma: The way forward Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-14 Chang-Keun Kim
Globally, over one in 10 children suffer from asthma which stands as the leading cause of morbidity in paediatrics as measured by school absenteeism, emergency department visits and hospitalizations.1 However, asthma management in children, particularly those below the age of 5 years, is far from being optimal and is associated with multiple challenges in diagnosis, disease severity assessment and
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Effects of cultured keratinocyte- and fibroblast-derived mediators on three-dimensional skin models Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-14 Melina Fonfara, Carina Brodersen, Ina Suhrkamp, Elke Rodriguez, Stephan Weidinger, Hila Emmert
Summary Box Keratinocytes secrete sufficient pro-inflammatory mediators to cause disease-associated patterns in 3D skin models IL-4Rα blockade only partly improves the skin barrier highlighting Th2-independent factors' role in skin inflammation
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Serum mast cell tryptase reference intervals in European populations Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-14 Erik Wilhelm Vinnes, Marie Bjørbak Alnæs, Torgeir Storaas
Summary Box Tryptase reference intervals have been well investigated and independently validated on different European populations. Our summary supports the recently proposed clinically normal range of 1–15 μg/L.
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Safety and effectiveness of a milk ladder for managing children with IgE-mediated milk allergy Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-09 Tessa Ah Heng, Caoimhe Cronin, Laura Flores, Francois Meyer, Meg O'Sullivan, Anne Marie McGinley, Sarah Hanley, Anne McKiernan, Yvonne D'Art, Jonathan O' B Hourihane, Roberto Velasco, Juan Trujillo
Summary Box 148/171 (87%) infants with IgE-mediated milk allergy successfully introduced milk using a home milk ladder. Allergic reactions were common, but the three anaphylaxis cases were triggered by accidental milk exposures.
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Predictors of oral food challenge outcome in young children. Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-08 Nagisa Ito,Kiwako Yamamoto-Hanada,Limin Yang,Yusuke Inuzuka,Fumi Ishikawa,Tatsuki Fukuie,Yukihiro Ohya
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Allergic diseases as risk factors for Long-COVID symptoms: Systematic review of prospective cohort studies Clin. Exp. Allergy (IF 6.1) Pub Date : 2023-11-08 Doreen Wolff, Karl Philipp Drewitz, Angela Ulrich, Doreen Siegels, Stefanie Deckert, Antonia Anabella Sprenger, Paula Ricarda Kuper, Jochen Schmitt, Daniel Munblit, Christian Apfelbacher