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Potential Tools for Predicting Response to Chemotherapy in OC: Assessment of Immune Dysbiosis, Participant’s Self-Rated Health and Microbial Dynamics J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-03-12 Taylor Badger, Elizabeth Anderson, Sarah Nelson, Kathleen Groesch, Teresa Wilson, Paula Diaz-Sylvester, Kristin Delfino, Nhung Le, Laurent Brard, Andrea Braundmeier-Fleming
Epithelial ovarian cancer (OC) is the deadliest female reproductive cancer; an estimated 13,270 women will die from OC in 2023. Platinum-based chemotherapy resistance mechanisms contribute to poor OC 5-year survival rates. Peripheral inflammation is linked to various disease states and we previously identified unique peritoneal microbial features predictive of OC. We hypothesized that unique peripheral
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Neutrophil extracellular traps (NET) in reproductive system and pregnancy complications J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-03-08 Lida Aslanian-Kalkhoran, Amir Mehdizadeh, Leili Aghebati-Maleki, Shahla Danaii, Sima Shahmohammadi-Farid, Mehdi Yousefi
Neutrophils are the main components of innate immunity to eliminate infectious pathogens. NET formation is a new mechanism of these cells for their defense function. These strands containing DNA and antimicrobial peptides were initially recognized as one of the defense mechanisms of neutrophils, but later it was explained that they are involved in a variety of non-infectious diseases. Since the source
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Associations between cytokines and the risk of female and male infertility: A two-sample Mendelian randomization analysis J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-03-08 Lei Zhang, Honglin Li, Zhijuan Wu, Letian Han, Jianwei Zhang
Observational studies have linked cytokines to the occurrence of female and male infertility. However, it is not clear how biomarkers of inflammation are causally related to infertility. To explore whether genetic variants in circulating cytokines are associated with the pathogenesis of infertility, we performed two-sample Mendelian randomization (MR) analysis. A total of 31,112 individuals of European
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High-dose oral contraceptives induce hyperinsulinemia without altering immune activation in diet-induced obesity which persists even following a dietary low-fat diet intervention J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-03-08 Oyesanmi A. Fabunmi, Phiwayinkosi V. Dludla, Bongani B. Nkambule
Combined oral contraceptives (COCs) are known to cause weight gain and alter metabolic and immunological pathways. However, modifications in arterial or venous thrombotic risk profiles of women of reproductive ages on COC remain unclear. The study aimed at assessing the impact of COC on immune activation in diet-induced obesity. We further established whether the dietary intervention of switching from
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Humoral immune transcriptome signature in myelomeningocele patients J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-03-08 RFM Felício, ALMM Franco, D. Corrêa-Moreira, F. Martinez de Carvalho, ACR Guimarães, FR Vargas
Myelomeningocele (MMC) results from incomplete closure of the neural tube, and has a complex multifactorial etiology, including an inflammatory microenvironment. We evaluated the contribution of humoral immune response for development of inflammatory milieu. Using public repository Gene Expression Omnibus (GEO), we retrieve dataset transcriptome from the amniotic fluid of ten fetuses with myelomeningocele
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HLA allele frequency of HLA-A, -B, -C, -DRB1 and -DQB1 in Indian Recurrent Implantation Failure and Recurrent Pregnancy Loss couples – a retrospective study J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-03-03 Sachin Shetty, Ashly Santhosh, Sree Parvathi S Pillai, Devika Gunasheela, Rajsekhar Nayak, Swathi Shetty
The maternal-fetal interaction has been hypothesized to involve the human leucocyte antigen (HLA). It has been suggested that excessive HLA antigen sharing between spouses is a mechanism causing maternal hyporesponsiveness to paternal antigens encountered during pregnancy and thus leading to a miscarriage. Participants in this retrospective study are RIF and RPL couples who visited Gunasheela Surgical
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Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-27 M.C. Krog, E.M. Flachs, A.M. Kolte, W. de Jager, L. Meyaard, O.B. Christiansen, R. Steffensen, K. Vomstein, P. Garred, H.S. Nielsen
The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of Mannose-binding-lectin (MBL), a pattern recognition molecule (PRM) of the lectin pathway, have been found in women with RPL. We propose that pregnancy loss is connected to defective
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How sperm protects itself: a journey in the female reproductive system J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-27 Nadia Sheibak, Zahra Zandieh, Fatemehsadat Amjadi, Reza Aflatoonian
Sperm must pass a complex route in the female reproductive tract (FRT) to reach the fertilization site and join the oocyte. Thus, it should employ several mechanisms to survive against the female immune system, fertilize the oocyte, and successfully transmit paternal genes to the next generation. In addition to self-protection, sperm may be involved in the immune tolerance to the developing embryo
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SARS-CoV-2 infection in pregnant patients on TNFα inhibitor: real-life data with a review of literature J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-21 Yiqi Yu, Jiaying Pan, Yiqi Zhao, Xiaoyan Guo, Wenting Yu, Feifei Zhou, Jing Shu, Qiongxiao Huang
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Research progress in rodent models of endometriosis J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-17 Yan Zeng, Fu Hang, Chuyu Peng, Ling Zhao, Shanshan Ou, Liumei Luo, Bo Liu
Endometriosis is a common and frequent disease in gynecology; its etiology and pathogenesis are partially understood and still not clear. The construction of suitable animal models is beneficial for basic research related to the disease. Currently, rodents have the advantages of low cost, fast reproduction, easy rearing, and a similar endometrial structure to humans. Depending on the purpose of the
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Exploring the effectiveness of endometrial receptivity array and immune profiling in patients with multiple implantation failure:a retrospective cohort study based on propensity score matching J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-17 Yan Jia, Yan Huang, Zhong-Hua Ai, Ya-Jun Dong, Yan-Hua Guo, Yue Yang, Dan Zhang, Hong-Xia Ye, Jie Yang
This study aimed to evaluate the effectiveness of the endometrial receptivity array (ERA), endometrial immune profiling, and a combination of both in improving the pregnancy outcomes in multiple implantation failure patients. According to patients’ willingness, 1429 women who incurred at least two or more consecutive implantation failures in IVF/ICSI treatment opted for frozen embryo transfer and were
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Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-16 Zahra Shiravani, Kimia Mirshekari, Marjan Hematian Larki, Nargess Shafiee, Mohammad Reza Haghshenas, Abbas Ghaderi, Mohammad Javad Fattahi
Endometrial cancer (EC) constitutes more than half of all genital cancers in women, with an increasing incidence in different countries. Natural killer cells (NK cells) are kinds of innate immune cells that are controlled by sets of receptors, such as killer cell Ig-like receptors (KIRs), which can inhibit or activate NK cells. In this study, we evaluated the diversity and genetic association of KIRs
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"Autoimmune Thyroid Disorders and Polycystic Ovary Syndrome: Tracing Links through Systematic Review and Meta-Analysis " J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-15 Seyed Sobhan Bahreiny, Akram Ahangarpour, Mahdi Amraei, Zahra Mansouri, Ali Pirsadeghi, Razieh Kazemzadeh, Moslem Javidan, Negin Karamali, Mohammad-Navid Bastani, Mohammad Reza Dabbagh
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Genome-wide association study in Estonia reveals importance of vaginal epithelium associated genes in case of recurrent vaginitis J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-13 Evelin Mutli, Reet Mändar, Kairi Koort, Andres Salumets, Estonian Biobank Research Team, Triin Laisk
Recurrent vaginitis is a leading reason for visiting a gynaecologist, with bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) being the most common diagnoses. Reasons and mechanisms behind their recurrent nature are poorly understood. We conducted a genome-wide association study (GWAS) to find possible genetic risk factors for recurrent vaginitis using data from a large population-based biobank
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Acute murine-betacoronavirus infection impairs testicular steroidogenesis and the quality of sperm production J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-13 A.F.A. Figueiredo, N.T. Wnuk, M.R.G. Brener, T.O. Farias, G.H. Campolina-Silva, A.C.S.P. Andrade, C.M. Queiroz-Junior, G.B. Menezes, M.M. Teixeira, V.V. Costa, G.M.J. Costa
Although several testicular alterations promoted by coronavirus infection have been demonstrated, the extent, causes, and players of testicular pathogenesis are not totally understood. The present study aimed to investigate the short-term effects on male fertility of intranasally administered murine hepatitis virus strain 3 (MHV-3), a member of the genus , which causes a severe systemic acute infection
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PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-09 Mingli An, Xinping Fu, Xin Meng, Huimin Liu, Yiming Ma, Ying Li, Qingxue Li, Jingwei Chen
Endometriosis (EMS) is known to be closely associated with inflammation. We evaluate the possible mechanism linking the PI3K/AKT signaling pathway with pyroptosis and inflammation in EMS. We collected 30 patients undergoing laparoscopic for endometriosis as the EMS group and those undergoing surgery for uterine fibroids as the control group, from whom we collected serum, normal endometrium, eutopic
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IFNT-induced IRF1 enhances bovine endometrial receptivity by transactivating LIFR J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-06 Bin Ma, Huiqi Cui, Xiao Wang, Wen Feng, Jinxin Zhang, Nuoer Chen, Talha Umar, Han Zhou, Wenjing Liu, Xinyu Feng, Ganzhen Deng
Interferon-τ (IFN-τ) participates in the establishment of endometrial receptivity in ruminants. However, the precise mechanisms by which IFN-τ establishes bovine endometrial receptivity remain largely unknown. Interferon regulatory factor 1 (IRF1) is a classical interferon-stimulated gene (ISG) induced by type I interferon, including IFN-τ. Leukemia inhibitory factor receptor (LIFR) is a transmembrane
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Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-03 Mina Toljic, Nadja Nikolic, Ivana Joksic, Jelena Carkic, Jelena Munjas, Natasa Karadzov Orlic, Jelena Milasin
Altered microRNAs (miRNAs) and cytokines expression levels are associated with several pregnancy-induced complications. We evaluated the profile of circulating miRNAs (miR-17, miR-29a and miR-181a) and proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-17) in women with gestational diabetes mellitus (GDM), as well as their potential use as GDM biomarkers. The case-control study included 65 pregnant
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The role of extracellular vesicles from placenta and endometrium in pregnancy: Insights from tumor biology J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-02-01 Yanjun Wang, Songchen Cai, Xian Chen, Qing Sun, Tailang Yin, Lianghui Diao
Extracellular vesicles (EVs) are small membrane-bound particles secreted by various cell types that play a critical role in intercellular communication by packaging and delivering biomolecules. In recent years, EVs have emerged as essential messengers in mediating physiological and pathological processes in tumor biology. The tumor microenvironment (TME) plays a pivotal role in tumor generation, progression
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Recurrent implantation failure and inflammatory markers in serum and follicle fluid of women undergoing assisted reproduction J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-30 Hannah Nenonen, Alexandra Kondic, Emir Henic, Ida Hjelmér
It has been shown previously that the immune system plays a role in implantation and embryo development. The objective was therefore to evaluate cytokine levels and Th1/Th2 ratio in women with recurrent implantation failure in this nested case-control study. Women with no implantation after ≥ 3 embryo transfers were included in the recurrent implantation failure group (n = 29) and were compared with
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Modulation of CD8+T cells, NK cells and Th1cytokines by metabolic milieu in decline of HBV-viremia in pregnant women treated with tenofovir-disoproxil from second trimester of pregnancy J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-28 Prabhjyoti Pahwa, Ashish Kumar Vyas, Jayesh Kumar Sevak, Ravinder Singh, Jaswinder Singh Maras, Sharda Patra, Shiv K. Sarin, Nirupama Trehanpati
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Unravelling the impact of COVID-19 on pregnancy: In aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-23 Şükriye Leyla Altuntaş, Arzu Güneş, Arife Ahsen Kaplan, Neşe Ayşit, İlknur Keskin
COVID-19 has turned into a global pandemic since it was first detected in 2019, causing serious public health problems. Our objective was to investigate the impact of COVID-19 on pregnant women and newborns, who belong to the vulnerable segments of society. Our study involved the histopathological examination of placentas and umbilical cords from two groups of pregnant women. Group I consisted of pregnant
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Fetal-origin cells in maternal circulation correlate with placental dysfunction, fetal sex, and severe hypertension during pregnancy J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-20 Heidi E. Fjeldstad, Daniel P. Jacobsen, Guro M. Johnsen, Meryam Sugulle, Angel Chae, Sami B. Kanaan, Hilary S. Gammill, Anne Cathrine Staff
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Circ_0030042 inhibits trophoblast cell growth, invasion and epithelial-mesenchymal transition process in preeclampsia via miR-942-5p/LITAF J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-17 Xiaolong Tian, Yajun Zhang, Meng Zhao, Xiaofang Yin
There is increasing evidence that circular RNAs (circRNAs) are involved in the processes of preeclampsia (PE). Circ_0030042 was found to be abnormally expressed in PE patients. However, the role and molecular mechanism of circ_0030042 in PE progression remains unclear. Quantitative real-time PCR was used for determining the expression of circ_0030042, microRNA (miR)− 942–5p and lipopolysaccharide induced
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Immunological effects of human decidual mesenchymal stem cells in spontaneous and recurrent abortions J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-15 Esra Esim Büyükbayrak, Nur Ecem Öztop Gündoğdu, Nihan Gürkan, Fatma Rabia Kahraman, Münip Akalın, Tunç Akkoç
The aim of this study was to evaluate the immunological activities of human decidual mesenchymal stem cells (MSCs) on proliferation, apoptosis and percentage of regulatory T cells (Treg) in abortions and to investigate whether these activities differ in spontaneous abortions (SA) and recurrent abortions (RA). This prospective cohort study included women who had a first-trimester abortion between 2019
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Concerns about an ancestry-focused explanation for racialized health disparities J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-15 Francois G. Rollin, Gabriella Mayne, Jessica Cerdena
Abstract not available
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The role of the endometrial microbiome in embryo implantation and recurrent implantation failure J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-06 Pourya Rokhsartalab Azar, Sarmad Karimi, Arian Haghtalab, Saman Taram, Milad Hejazi, Sonia Sadeghpour, Mohammad Reza Pashaei, Hojat Ghasemnejad-Berenji, Mortaza Taheri-Anganeh
There is a suggested pathophysiology associated with endometrial microbiota in cases where repeated implantation failure of high-quality embryos is observed. However, there is a suspected association between endometrial microbiota and the pathogenesis of implantation failure. However, there is still a lack of agreement on the fundamental composition of the physiological microbiome within the uterine
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Cytoplasmic and nuclear DROSHA in human villous trophoblasts J. Reprod. Immunol. (IF 3.4) Pub Date : 2024-01-02 Syunya Noguchi, Sadayuki Ohkura, Yasuyuki Negishi, Shohei Tozawa, Takami Takizawa, Rimpei Morita, Hironori Takahashi, Akihide Ohkuchi, Toshihiro Takizawa
In villous trophoblasts, DROSHA is a key ribonuclease III enzyme that processes pri-microRNAs (pri-miRNAs) into pre-miRNAs at the placenta-specific, chromosome 19 miRNA cluster (C19MC) locus. However, little is known of its other functions. We performed formaldehyde crosslinking, immunoprecipitation, and sequencing (fCLIP-seq) analysis of terminal chorionic villi to identify DROSHA-binding RNAs in
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Placentation and complications of ART pregnancy. An update on the different possible etiopathogenic mechanisms involved in the development of obstetric complications J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-30 Francesco Galanti, Serena Riccio, Andrea Giannini, Ottavia D’Oria, Giovanni Buzzaccarini, Maria Scudo, Ludovico Muzii, Francesco Antonino Battaglia
Infertile couples’ percentage is increasing all over the world, especially in Italy, with high number of children born in our country through assisted reproductive techniques (ART). However, pregnancies obtained by ART have increased potential obstetrical risks which could be caused by fetus-placenta unit development, most of all due to placentation’s evolution. These can be reassumed into miscarriage
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The role of first trimester serum inflammatory indexes (NLR, PLR, MLR, SII, SIRI, and PIV) and the β-hCG to PAPP-A ratio in predicting preeclampsia J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-30 Zeynep Seyhanli, Burak Bayraktar, Onur Baran Baysoz, Gulsan Karabay, Serap Topkara Sucu, Can Ozan Ulusoy, Gizem Aktemur, Mevlut Bucak, Betul Tokgoz Cakir, Dilara Kurt, Seval Yilmaz Ergani, Can Tekin Iskender
The aim of this study was to investigate the predictive value of inflammation parameters and indices measured in the first trimester for the detection of preeclampsia. In this retrospective analysis, we examined the medical records of 276 eligible pregnancies at a tertiary referral center from 2022 to 2023. The cases were categorized into the Control group (n = 171), the Mild Preeclampsia group (n = 63)
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Expanding the role of chromosomal microarray analysis in the evaluation of recurrent pregnancy loss J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-28 Jasmine Eliwa, Ralph S. Papas, William H. Kutteh
Multiple factors contribute to recurrent pregnancy loss (RPL). This review highlights the latest international guidelines for RPL workup, including immunological testing, by the American Society for Reproductive Medicine (ASRM), the European Society of Human Reproduction and Embryology (ESHRE), and the Royal College of Obstetricians and Gynaecologists (RCOG). These three societies recommend testing
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BeWo exomeres are enriched for bioactive extracellular placenta-specific C19MC miRNAs J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-23 Syunya Noguchi, Shohei Tozawa, Takanobu Sakurai, Akihide Ohkuchi, Hironori Takahashi, Hiroyuki Fujiwara, Toshihiro Takizawa
Extracellular vesicles (EVs), including exosomes, are carriers of extracellular microRNAs (miRNAs). Exomeres, non-vesicular extracellular nanoparticles (NVEPs), are novel extracellular cargo carriers. However, little is known of the characteristics of placental trophoblast-derived exomeres. In this study, we characterized trophoblast-derived exomeres and investigated the cell–cell communication of
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Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-19 Yui Ito, Takuro Kobori, Yoko Urashima, Takuya Ito, Kikuko Hotta, Tokio Obata
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Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-18 Yutong Cui, Suwen Wu, Ketong Liu, Huanqiang Zhao, Bo Ma, Lili Gong, Qiongjie Zhou, Xiaotian Li
Introduction Severe preeclampsia (sPE) is a systemic syndrome that may originate from chronic inflammation. Maintaining maternal-fetal hemostasis by the co-inhibitory molecule programmed death ligand 1 (PDL1) can be favorable for ameliorating inflammation from immune cells. Apart from programmed death 1 (PD1) expression, decidual macrophages (dMs) produce inflammatory cytokines, in response to cells
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The effect of seminal pathogens on standard semen parameters, sperm kinematics and seminal inflammatory markers J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-17 Artin Aghazarian, Wolfgang Huf, Hans Christoph Klingler, Tobias Klatte
This study evaluated the effects of urogenital pathogens on standard semen parameters, sperm kinematics and host inflammatory response in a cohort of asymptomatic subfertile men. There were six groups based on the results of bacterial culture, including Ureaplasma urealyticum (U. Urealyticum) (n = 27), mixed comprising two or more pathogenic species (n = 28), Gardnerella Vaginalis (G. Vaginalis) (n = 15)
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Frequent expression of CD45RO memory T cell marker as well as low to high expression of PD-1 and PD-L1 inhibitory molecules in seminoma and dysgerminoma J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-15 Hadiseh Farahani, Amir Reza Dehghanian, Aida Khademolhosseini, Mohammad Reza Haghshenas, Nasrollah Erfani
Background Seminoma and dysgerminoma are rare testicular and ovarian germ cell tumors characterized by a significant infiltration of immune cells in the tumor microenvironment. According to the failure of conventional treatments in some patients, it is crucial to identify novel prognostic and therapeutic biomarkers for these patients. The objectives of this study were to evaluate the expression of
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Exploring Lactoferrin as a novel marker for disease pathology and ferroptosis regulation in gestational diabetes J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-14 Sundhar Mohandas, Kunnath Lakshmanan Milan, Murugesan Anuradha, Kunka Mohanram Ramkumar
Iron overload is linked to heightened susceptibility to ferroptosis, a process increasingly implicated in diabetes pathogenesis. This present study aims to assess the utility of Lactoferrin in predicting different stages of GDM and explore its association with disease pathology and ferroptosis. In this observational study, 72 pregnant women were recruited and categorized into three groups: healthy
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Effects of calcitriol upon TGF-βs and their receptors in trophoblast cells J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-12-10 Nancy Noyola-Martínez, Mayel Chirinos, Ixchel Ramírez-Camacho, Joselin Estefania Escamilla-Bucio, Mitzi García-Olivares, Juan Pablo Aragón-Hernández, Mariana Segovia-Mendoza, Ali Halhali, David Barrera
Calcitriol levels increase during pregnancy, contributing to the hormonal and immunological balance, but its deficiency has been associated with problems during this period. Meanwhile, transforming growth factors-β (TGF-βs) play an important role in the maintenance of fetal-maternal immune tolerance; however, exacerbated concentrations of this growth factor are associated with complicated pregnancies
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NLRP3 inflammasome pathway, the hidden balance in pregnancy: A comprehensive review J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-28 Cemre Nur Balci, Nuray Acar
The balance of the inflammatory response is indispensable during pregnancy. Inflammasomes are the cytosolic supramolecular protein complexes activated by pattern recognition receptors. These receptors recognize the pathogen and damage/danger-associated molecular patterns. NLRP3 inflammasome complex consists mainly of NLRP3 (leucine-rich repeat-containing and pyrin domain-containing protein 3), a cytosolic
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Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-30 Nándor Gábor Than, Roberto Romero, Máté Posta, Dániel Györffy, Gábor Szalai, Simona W. Rossi, András Szilágyi, Petronella Hupuczi, Sándor Nagy, Olga Török, Adi L. Tarca, Offer Erez, Nándor Ács, Zoltán Papp
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous
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L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-24 Colm J. McElwain, Andrea Musumeci, Samprikta Manna, Fergus P. McCarthy, Cathal M. McCarthy
Background Maternal hyperglycaemia has a significant impact on placental metabolism and mitochondrial function. The NLRP3 inflammasome is responsive to endogenous signals of mitochondrial dysfunction. We tested our hypothesis that mitochondrial dysfunction orchestrates activation of the NLRP3 inflammasome and contributes to inflammation in gestational diabetes mellitus (GDM). Methods Fasting blood
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Role of macrophage colony stimulating factor and interferon regulatory factor 7 in modulating the immune profile of mouse testicular macrophages J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-21 Yalong Yang, Vishnu Kumar, Wei Peng, Monika Fijak, Michel Gabriela, Wei Cai, Andreas Meinhardt, Sudhanshu Bhushan
Testicular macrophages (TM) are critical for the function of the testis by regulating homeostasis and inflammatory responses. However, the mechanisms by which TM fulfil these roles remain elusive. In this study, we explored the impact of two key testicular microenvironmental factors, namely 25-hydroxycholesterol (25HC), an oxysterol related to sex hormones and macrophage colony-stimulating factor (M-CSF)
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Title: Repeated implantation failure is associated with increased Th17/Treg cell ratio, during the secretory phase of the human endometrium J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-19 Aikaterini Berdiaki, Eleni Vergadi, Fanourios Makrygiannakis, Thomas Vrekoussis, Antonios Makrigiannakis
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Corrigendum to “Actually laboratory parameters for prognosis of fertility in varicocele patients” J. Reprod. Immunol. 159C (2023) 104058 J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-16 Nakonechnyi Yozef, Nakonechnyi Andrey, Fraczek Monika, Havrylyuk Anna, Kamieniczna Marzena, Chopyak Valentyna, Kurpisz Maciej
Abstract not available
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Increasing expression of STING by ERα antagonizes LCN2 downregulation during chronic endometritis J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-07 Min Chu, Shunzhi He, Huishan Zhao, Shuyuan Yin, Zhenteng Liu, Wei Zhang, Xuemei Liu, Hongchu Bao
Chronic endometritis has a high incidence in infertile women, which is caused by endometrial microbiome infection. In response to microbial infection, the role of defensins during chronic endometritis need explored. Besides, the expression of estrogen and its receptors vary in different menstrual cycles, but their roles in chronic endometritis are still unclear. In this study, we used the human endometrial
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What’s with the boys? Lower birth weight in boys from HPA-1a alloimmunized pregnancies – New insights from a large prospective screening study in Poland J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-07 Tina Coucheron, Malgorzata Uhrynowska, Katarzyna Guz, Agnieszka Orzińska, Marzena Debska, Agnieszka Gierszon, Maria Therese Ahlen, Eirin Listau Bertelsen, Gerd Berge, Anne Husebekk, Ewa Brojer, Heidi Tiller
Fetomaternal incompatibility in human platelet antigens (HPAs) can cause maternal alloimmunization, which in turn may lead to thrombocytopenia with or without intracranial hemorrhage (ICH) in the fetus or newborn. Retrospective studies suggest that boys from alloimmunized mothers may have higher risk of ICH and lower birth weight than girls. The objective of this study was to assess how maternal HPA-1a
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Sleep deprivation during pregnancy leads to poor fetal outcomes in Sprague–Dawley rats J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-11-02 Jinzhi Li, Xiuhua Peng, Hequan Zhong, Songping Liu, Jimin Shi, Xiaohui Zhou, Bing Li
Sleep deprivation is a common problem during pregnancy, but its impact on the fetus remains unclear. We aimed to investigate the effect of sleep deprivation during pregnancy on fetal outcomes and its mechanism in Sprague–Dawley rats. Sleep deprivation was performed from gestational day(GD) 1–19 using a multiplatform method for 18 h/day. Rats were sacrificed on GD20, and their blood and placentas were
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Ovarian follicle transcriptome dynamics reveals enrichment of immune system process during transition from small to large follicles in cyclic Indian Ghoongroo pigs J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-10-24 Jaya Bharati, Satish Kumar, N.H. Mohan, Bikash Chandra Das, Salam Jayachitra Devi, Vivek Kumar Gupta
Ovarian follicular development is a critical determinant of reproductive performance in litter bearing species like pigs, wherein economic gains depend on litter size. The study aimed to gain insight into the differentially expressed genes (DEGs) and signalling pathways regulating follicular growth and maturation in Ghoongroo pigs. Transcriptome profiling of porcine small follicles (SF) and large follicles
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Investigations of leukocyte and inflammatory markers in pregnancies complicated by preeclampsia J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-10-09 Hiba Iraqi Møller, Gry Persson, Freja Bluhme Klok, Fie Juhl Vojdeman, Morten Lebech, Thomas Vauvert F. Hviid
Objectives Preeclampsia is a frequent and potentially fatal pregnancy complication. It can be challenging to make a timely diagnosis. Identifying clinically useful biochemical markers would be a remedying tool to support the diagnosis of preeclampsia. The aim was to investigate differential cell counts and acute phase reactants as diagnostic markers of preeclamptic third-trimester pregnancies and in
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Assessing the endometrium: An update on current and potential novel biomarkers of receptivity J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-10-07 J. Garratt, M. Rahmati
A cyclical evolvement of the endometrium into a transient state of receptivity is crucial for acceptance of the semi-allogeneic foetus, conducive to pregnancy. Despite documentation of aberrances in this process within patients experiencing repeated embryo implantation failures and miscarriages, the endometrium is often overlooked in IVF clinics as the cause for failure. Focus instead is usually given
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Placenta and maternal endothelium during preeclampsia: Disruption of the glycocalyx explains increased inositol phosphoglycans and angiogenic factors in maternal blood J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-10-05 Marco Scioscia, Monika Siwetz, Pierre-Yves Robillard, Agostino Brizzi, Berthold Huppertz
The etiology of the pregnancy syndrome preeclampsia is still unclear, while most hypotheses center on the placenta as the major contributor of the syndrome. Especially changes of the placental metabolism, including the use of glucose to produce energy, are important features. As an example, inositol phosphoglycan P-type molecules, second messengers involved in the glucose metabolism of all cells, can
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Regulatory role of human endometrial gland secretome on macrophage differentiation J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-09-30 Leqian Lin, Kunfeng Bai, Jianlin Li, Philip C.N. Chiu, Cheuk-Lun Lee
The human endometrial gland plays a vital role in maternal immune tolerance and placental development. Decidual macrophages are the major phagocytic cells that regulate tissue remodeling during pregnancy. This study examines the regulatory effect of endometrial gland secretome on macrophage polarization and functions using endometrial organoid. We demonstrated that endometrial organoids treated with
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HNRNPC mediated m6A methylation of 5-methyltetrahydrofolate-homocysteine methyltransferase and involved in the occurrence of RSA J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-10-04 Mengting Zhang, Nana Huang, Yue Gao, Zhanqi Feng, Bing Kang, Han Guo, Jincheng Jiang, Shixiu Liao, Hongdan Wang
N6‐methyladenosine methylated modification has been shown to play roles in recurrent spontaneous abortion. We aimed to explore role of heterogeneous nuclear ribonucleoprotein C in the occurrence of recurrent spontaneous abortion. We collected embryonic villous tissues from 3 patients with recurrent spontaneous abortion (RSA group) and 3 normal control pregnancy patients. Methylated RNA immunoprecipitation
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Reduced expression of miR-221 is associated with the pro-apoptotic pathways in spermatozoa of oligospermia men J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-10-03 Mohamed J. Saadh, Renzon Daniel Cosme Pecho, Azfar Jamal, Abdulaziz S. Alothaim, Mohammad Azhar Kamal, Mohiuddin Khan Warsi, Fuzail Ahmad, Mohammed Obaid, Hani Moslem, H.A. Zainab, Ali H. Amin, José Luis Arias-Gonzáles, Ria Margiana, Reza Akhavan-Sigari
Oligospermia and asthenozoospermia, both frequent, can lead to male infertility. Oligospermia might be viewed as a milder form of azoospermia because the same mutations that produce azoospermia in some individuals also create oligospermia in other individuals. In this, we looked at different characteristics of oligospermia men, counting the level of apoptosis and a few related apoptotic and oxidative
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Calcineurin inhibitors in the management of recurrent miscarriage and recurrent implantation failure: Systematic review and meta-analysis J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-09-30 Marcelo Borges Cavalcante, Ana Clara Muniz Tavares, Camila Alves Rocha, Giselle Ferreira de Souza, Eduarda Maia Lima, Júlia Machado Luz Simões, Larissa Cruz de Souza, Maria Yzadora Moura Martins, Nicole Oliveira de Araújo, Ricardo Barini
Recurrent miscarriage (RM) affects up to 2.5% of couples of reproductive age. Up to 10% of couples using assisted reproductive technology experience recurrent implantation failure (RIF). Immunosuppressive drugs, such as calcineurin inhibitors (CNIs), has been proposed for RM and RIF management. This systematic review and meta-analysis (SRMA) aimed to evaluate the efficacy and safety of CNIs in RM and
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Granulocyte-macrophage colony-stimulating factor promotes endometrial repair after injury by regulating macrophages in mice J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-09-23 Xiaohong Zhu, Sijia Chen, Peipei Zhang, Yana Ma, Xiu Liu, Haiyi Fei, jingjing Qian, Yanqing Hao, Lingling Jiang, Xiaona Lin
Intrauterine adhesion (IUA) caused by endometrial injury is a common cause of female infertility and is challenging to treat. Macrophages play a critical role in tissue repair and cyclical endometrial regeneration. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has significant reparative and anti-fibrotic effects in various tissues. However, there is limited research on the role of GM-CSF
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Impaired decidualization and relative increase of PROK1 expression in the decidua of patients with unexplained recurrent pregnancy loss showing insulin resistance J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-09-22 Shinobu Goto, Yasuhiko Ozaki, Fumiko Ozawa, Hiroyuki Yoshihara, Dorina Ujvari, Tamao Kitaori, Mayumi Sugiura-Ogasawara
A recent meta-analysis revealed that patients with unexplained recurrent pregnancy loss (RPL) show higher insulin resistance compared to healthy controls. However, the etiology of RPL remains unknown. Prokineticin (PROK1), a pleiotropic uterine endometrial protein, is important for implantation and decidualization and is regulated by hypoxia and insulin. In this study, we investigated the decidualization
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Effect of Kangfuxiaomi suppository on pelvic inflammatory disease in rats J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-09-20 Rui Wang, Xiu-Qin Li, Meng-Ru Wang, Xiu-Mei Wu, Yu-Sheng Xu, Ahunova Hilola, Xue-Chang Wang, Heng Liu
Pelvic inflammatory disease (PID) is commonly encountered in gynecological practice. Kangfuxiaomi suppository, made from the compound extract of Periplaneta Americana, is a Traditional Chinese Medicine remedy widely used for the treatment of gynecological disorders. This study aimed to preliminarily explore the therapeutic effect of Kangfuxiaomi suppository in a rat model of PID established by chemical
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Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta J. Reprod. Immunol. (IF 3.4) Pub Date : 2023-09-17 Manami Yanagisawa, Takeshi Nagamatsu, Makoto Kurano, Fumi Misumi, Ayumi Taguchi, Naoya Akiba, Mari Ichinose, Keiichi Kumasawa, Takayuki Iriyama, Tomoyuki Fujii, Yutaka Yatomi, Yutaka Osuga
The response of autotaxin (ATX)–lysophosphatidic acid (LPA) signaling system to placental oxidative stress (OS) and its significance to preeclampsia were investigated. For this purpose, oxidative stress index (OSI) and ATX levels were measured in the serum of pregnant women with preeclampsia. The expression levels of ATX and LPA receptors were assessed in trophoblast cells under high OS and glucose