样式: 排序: IF: - GO 导出 标记为已读
-
Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-03-12 Xiaoqiang Liu, Yuqing Wang, Xiaoyang Wen, Cuifang Hao, Jinlong Ma, Lei Yan
BackgroundEndometritis is an inflammatory reaction of the lining of uterus, leading to the occurrence of infertility. Platelet rich plasma (PRP) has been proven to exhibit extremely effective for the treatment of endometrium‐associated infertility, but the mechanism of its prevention for endometritis remains unclear.ObjectiveThe present study aimed to investigate the protective effect of PRP against
-
Immunological regulation and the role of autophagy in preeclampsia Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-03-12 Akitoshi Nakashima, Atsushi Furuta, Mihoko Yoshida‐Kawaguchi, Kiyotaka Yamada, Haruka Nunomura, Keiko Morita, Ippei Yasuda, Satoshi Yoneda, Akemi Yamaki‐Ushijima, Tomoko Shima, Sayaka Tsuda
Autophagy is a bulk degradation system that maintains cellular homeostasis by producing energy and/or recycling excess proteins. During early placentation, extravillous trophoblasts invade the decidua and uterine myometrium, facing maternal immune cells, which participate in the immune suppression of paternal and fetal antigens. Regulatory T cells will likely increase in response to a specific antigen
-
Hyposecretion of cervical MUC5B is related to preterm birth in pregnant women after cervical excisional surgery Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-03-11 Yusuke Ueda, Haruta Mogami, Yoshitsugu Chigusa, Yosuke Kawamura, Asako Inohaya, Masahito Takakura, Eriko Yasuda, Yu Matsuzaka, Miho Shimada, Shinji Ito, Satoshi Morita, Masaki Mandai, Eiji Kondoh
ProblemExcisional surgery for cervical intraepithelial neoplasia is a risk factor for preterm birth in subsequent pregnancies. However, the underlying mechanisms of this association remain unclear. We previously showed that cervical MUC5B, a mucin protein, may be a barrier to ascending pathogens during pregnancy. We thus hypothesized that hyposecretion of cervical MUC5B is associated with preterm birth
-
Soluble MICA in endometriosis pathophysiology: Impairs NK cell degranulation and effector functions Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-03-08 Maria Lucia Carnevale Marin, Marici Rached Rached, Sandra Maria Monteiro, Jorge Kalil, Mauricio Simoes Abrao, Verônica Coelho
ProblemEndometriosis exhibits several immune dysfunctions, including deficient natural killer (NK) cell cytotoxicity. MICA (MHC class I chain‐related molecule A) is induced by biological stress and soluble MICA (sMICA) negatively modulates the expression of the activating receptor, NKG2D, reducing NK cells activities. We investigated the involvement of soluble MICA in NK cell‐deficient activity in
-
SARS‐CoV‐2 infection negatively impacts on the quality of embryos by delaying early embryonic development Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-03-06 Linna Ma, Yufei Yao, Zhao Zhang, Yanhua Huang, Liuguang Zhang, Pengyun Qiao, Jinyu Kang, Chune Ren, Wenling Xie, Rongwei Liang, Hongbo Wu, Zheng Liu, Yanlin Ma
BackgroundThe COVID‐19 pandemic is an unprecedented health crisis that has affected in vitro fertilization practices globally. Previous studies have shown that SARS‐CoV‐2 impacts the quality of embryos by inducing an immunological response in infertile patients. In this study, the early embryonic development of SARS‐CoV‐2‐infected infertile patients was investigated.MethodsSixty‐five SARS‐CoV‐2 infected
-
Meta‐analysis of FOXP3 polymorphisms and recurrent spontaneous abortion susceptibility Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-03-04 Ruzhen Shuai, Dandan Li, Xincong Xu, Xiaojuan Yang, Dan Liu
BackgroundThe polymorphisms of the FOXP3 gene may mediate abnormalities in Tregs, leading to an imbalance in maternal‐fetal immune tolerance and ultimately resulting in recurrent spontaneous abortion (RSA). This meta‐analysis aims to assess the potential association between FOXP3 polymorphisms and susceptibility to RSA using five specific single nucleotide polymorphisms (SNPs).Materials and methodsBy
-
In premature rupture of membranes, maternal serum delta neutrophil index may be a predictive factor for histological chorioamnionitis and affect fetal inflammatory markers: A retrospective cross‐sectional study Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-26 Yusuf Dal, Şebnem Karagün, Fatih Akkuş, Hatun Çolak, Hakan Aytan, Ayhan Coşkun
ProblemWe aimed to investigate the predictive value of delta neutrophil index (DNI) for histological choriomanionitis (HCAM) and the effect of maternal inflammatory markers on neonatal outcomes and fetal inflammatory parameters.Method of StudyIn this retrospective cross‐sectional study, 68 pregnant women without HCAM (group 1) and 46 pregnant women diagnosed with HCAM (group 2) were divided into two
-
Preconception anti‐annexin A5 antibodies are associated with subsequent live birth in women with recurrent miscarriage: A retrospective study from China Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-26 Fangxiang Mu, Chen Wang, Ling Liu, Fang Wang
ProblemTo evaluate the correlation between the antiannexin A5 antibodies (aAnxA5) multiples of median (MOM) and subsequent pregnancy outcomes in women with recurrent miscarriage (RM).MethodsTotally, 310 RM women were included in this study and grouped into tertiles according to their MOM of preconception aAnxA5 circulating levels determined by ELISA. The effect of aAnxA5 on the pregnancy outcomes was
-
An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-24 Bekir Sitki Isenlik, Mehmet Cihan Sarica, Bilgesu Cetinel Kaygun, Hasan Ali Inal
ObjectiveThis study investigated whether serum amyloid A (AA) levels can be used as a biomarker in patients with threatened abortion.Material and MethodsThis prospective cohort study was conducted at the Antalya Training and Research Hospital, Department of Obstetrics and Gynecology, Türkiye, between April and October 2023. Eighty‐eight pregnant women, 44 diagnosed with threatened miscarriage (Group
-
Identification and molecular characterization of genes modulating progression of an oocyte from M‐I to M‐II in rat ovary Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-23 Alka Sharma, Pawan K. Dubey, Pradeep Kumar, Kavindra Nath Tiwari, Anima Tripathi
BackgroundTo achieve oocyte competence for successful fertilization, bidirectional communication between oocyte and granulosa cells is crucial. The acquisition of meiotic competency in oocyte is facilitated by various regulatory genes however, expression pattern of these genes is not well documented during meiotic transition from Metaphase‐I to Metaphase‐II stage. Therefore, the present research analyzed
-
Pregnant individuals with uncomplicated pregnancies display pro‐inflammatory immune changes when exposed to the COVID‐19 pandemic Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-20 Elsa Bernier, Marie‐Eve Brien, Sylvie Girard
ProblemThe COVID‐19 pandemic has been shown to have a detrimental impact on the mental health of pregnant individuals, and chronic stress can alter the immune profile. However, the effects of the COVID‐19 pandemic on the immune system in pregnancy are still poorly understood. We aimed to evaluate the impact of pandemic exposure on the maternal immune profile in uncomplicated pregnancies.Method of studyWe
-
MicroRNA mediated regulation of oxidative stress and cytokines in Chlamydia trachomatis‐infected recurrent spontaneous abortion: A case‐control study Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-20 Ankita Ray, Dibyabhaba Pradhan, Fouzia Siraj, Renu Arora, Sangita Rastogi
ProblemIncreased oxidative stress (OS) and inflammatory responses are major underlying factors behind Chlamydia trachomatis‐associated recurrent spontaneous abortion (RSA). miRNAs are known to regulate inflammation and OS and their dysregulation has been associated with compromised pregnancies. Therefore, aim of this study was to investigate the expression/correlation of OS biomarkers, cytokines and
-
Causal relationship between gut microbiome and sex hormone-binding globulin: A bidirectional two-sample Mendelian randomization study Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-15 Ziqiao Yan, Zheng Zheng, Tiantian Xia, Zhexin Ni, Yongqi Dou, Xinmin Liu
Currently, there is a variety of evidence linking the gut microbiota to changes in sex hormones. In contrast, the causal relationship between SHBG, a carrier of sex hormones, and the gut microbiota is unclear.
-
The use of immunomodulation therapy in women with recurrent implantation failure undergoing assisted conception: A multicentre cohort study Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-13 Mohammed Khairy, Hoda Harb, Abey Eapen, Pedro Melo, Rahnuma Kazem, Madhurima Rajkhowa, George Ndukuwe, Arri Coomarasamy
Recurrent implantation failure (RIF) after multiple embryo transfers remains a vexing problem and immunomodulators have been used with conflicting results. This study aims to assess the effect of immunomodulation therapy on live birth rate (LBR) in women with RIF undergoing assisted reproduction treatment (ART).
-
Autophagy activation alleviates the LPS-induced inflammatory response in endometrial epithelial cells in dairy cows Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-08 Junsheng Dong, Bowen Ji, Yongshuai Jiang, Kangjun Liu, Long Guo, Luying Cui, Heng Wang, Bichun Li, Jianji Li
Endometritis is a common disease that affects dairy cow reproduction. Autophagy plays a vital role in cellular homeostasis and modulates inflammation by regulating interactions with innate immune signaling pathways. However, little is known about the regulatory relationship between autophagy and inflammation in bovine endometrial epithelial cells (BEECs). Thus, we aimed to determine the role of autophagy
-
Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case-control study Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-02-04 Gulzhanat Aimagambetova, Aizhan Kapasheva, Wael Bahia, Kuralay Atageldiyeva, Wassim Y. Almawi
This study analyzed the contribution of DRB1, DQB1, and DPB1 HLA class II alleles and resulting 3-locus haplotypes to the overall risk of idiopathic recurrent pregnancy loss (RPL).
-
Vaginal candida infection is associated with host molecular signatures of neutrophil activation in the adjacent ectocervical mucosa in Kenyan sex workers Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-31 Tyra Hasselrot, Mathias Franzén Boger, Vilde Kaldhusdal, Alexandra Åhlberg, Kenneth Omollo, Julie Lajoie, Joshua Kimani, Annelie Tjernlund, Keith R. Fowke, Paulo Czarnewski, Kristina Broliden
Overgrowth of candida species in the human vaginal mucosa causes inflammation, which could render the mucosal barrier more susceptible to HIV infection. Here, we investigated whether this condition also affects the ectocervical mucosa, a potential site of HIV entry, in women at high risk of HIV infection.
-
Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal-fetal interface in recurrent spontaneous abortion Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-31 Yanhong Yang, Saizhe Song, Shuting Gu, Yanzheng Gu, Ping Zhao, Dongxiao Li, Wei Cheng, Cuiping Liu, Hong Zhang
Immune factors are crucial in the development of recurrent spontaneous abortion (RSA). This study aimed to investigate whether kisspeptin regulates immune cells at the maternal-fetal interface and whether G protein-coupled receptor 54 (GPR54) is involved in this process, through which it contributes to the pathogenesis of RSA.
-
Dietary restriction-induced alterations on estrogen receptor alpha expression in regulating fertility in male Coturnix coturnix japonica: Relevance of Withania somnifera in modulation of inflammation and oxidative stress in testis Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-29 Kalpana Baghel, Zaffar Azam, Rashmi Srivastava
Reproductive performance of animals gets affected by nutritional restrictions which act as potential stressors leading to hormonal imbalance and testicular inflammation, the major causes of infertility. Withania somnifera (WS), well-known traditional medicinal plant, has been used as antistress and infertility treatment. Therefore, the present study looks into the ameliorative effects of WS on the
-
Highlighting inaccurate data supporting prednisolone administration in recurrent pregnancy loss: Comments on frequently cited meta-analysis Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-23 Y. L. B. N. Béquet, M. L. P. van der Hoorn, E. E. L. O. Lashley
In 2015, Dan et al. published the systematic review and meta-analysis “Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis”.1 This meta-analysis showed that prednisolone therapy resulted in higher live birth rate (RR 1.58, 95% CI 1.23−2.02) and lower miscarriage rate (RR 0.42, 95% CI 0.28−0.61) in
-
Study on the clinical value of Vitamin D in recurrent spontaneous abortion Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-18 Wenqi Du, Chao Ye, Yunjun Lin, Hongbo Zhai, Jianmei Xia
This study explores the possible pathogenesis of recurrent spontaneous abortion (RSA) caused by vitamin D (VD), provides evidence-based bases for prevention and treatment of RSA, improves female reproductive health.
-
Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-15 Tatsunori Shiraishi, Mariko Ikeda, Takami Watanabe, Yasuyuki Negishi, Go Ichikawa, Hanako Kaseki, Shigeo Akira, Rimpei Morita, Shunji Suzuki
In women of reproductive age, endometriosis may contribute to dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, adenomyosis, and endometrial ovarian cyst (EOC). Recent studies have shown that chronic inflammation occurs in the pelvis of endometriosis patients and that this inflammation is exacerbated by immunosuppression, leading to survival endometrial debris. However, the detailed immunological
-
Leptin promotes proliferation of human undifferentiated spermatogonia by activating the PI3K/AKT/mTOR pathway Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-16 Song Xin, Li Xiaoxuan, Zhang Yixuan, Cai Zhikang
Male infertility is a common disease affecting male reproductive health. Leptin is an important hormone that regulates various physiological processes, including reproductive function. However, few experimental studies have been carried out to elucidate the mechanism of leptin's effects on male reproductive function.
-
Pregnancy in pemphigus vulgaris: A systematic review Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-16 Yining Lan, Hanlin Zhang, Hongzhong Jin
Pemphigus vulgaris may worsen during pregnancy, leading to both maternal and fetal complications. The relationship between pemphigus vulgaris and pregnancy remains unclear, and the outcomes and treatments of pemphigus vulgaris during pregnancy have not been extensively discussed.
-
The predictive value of serum IL-17A and IL-6 expression in postoperative recurrence in patients with intrauterine adhesion Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-14 Xia Cui, Hui-Chao Xiao, Wen Pan
The recurrence rate of intrauterine adhesions (IUA) was high. At present, there are few studies on the relationship between proinflammatory factors IL-17A and IL-6 and IUA. The expression of serum IL-17A and IL-6 in IUA patients and their predictive value for postoperative recurrence were retrospectively analyzed.
-
The antioxidant N-acetyl cysteine inhibits cytokine and prostaglandin release in human fetal membranes stimulated ex vivo with lipoteichoic acid or live group B streptococcus Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-09 Hae-Ryung Park, Sean M. Harris, Erica Boldenow, David M. Aronoff, Meaghan Rea, Chuanwu Xi, Rita Loch-Caruso
Infection during pregnancy is a significant public health concern due to the increased risk of adverse birth outcomes. Group B Streptococcus or Streptococcus agalactiae (GBS) stands out as a major bacterial cause of neonatal morbidity and mortality. We aimed to explore the involvement of reactive oxygen species (ROS) and oxidative stress pathways in pro-inflammatory responses within human fetal membrane
-
Potential of plasma inflammatory and angiogenic mediators for predicting spontaneous preterm delivery, intraamniotic infection/inflammation, and composite neonatal morbidity/mortality in women with early preterm premature rupture of membranes Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2024-01-09 Hyeon Ji Kim, Kyo Hoon Park, Eunwook Joo, Min Jung Lee, Bo Young Choi
To assess the potential of five inflammatory and six angiogenic/antiangiogenic plasma proteins for predicting imminent spontaneous preterm delivery (SPTD; ≤14 days of sampling), microbial invasion of the amniotic cavity and/or intraamniotic inflammation (MIAC/IAI), and composite neonatal morbidity and mortality (CNMM) in women with early preterm premature rupture of membranes (PPROM).
-
Progesterone-induced blocking factor blockade causes hypertension in pregnant rats Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-21 Alexis Meadors, Kyleigh Comley, Jesse N. Cottrell, Tarek Ibhahim, Mark W. Cunningham, Lorena M. Amaral
Preeclampsia (PE) is a multisystem disorder characterized by new onset hypertension in mid-late gestation and can include multi-organ dysfunction with or without proteinuria. It affects 5%–7% of all pregnancies in the U.S., making PE a major contributor to maternal and fetal morbidity and mortality. Currently, there is no cure for this pregnancy complication except for early delivery of the placenta
-
The role of inflammation in cases with gestational diabetes mellitus: Systemic immune inflammatory index according to trimesters Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-22 Seval Yılmaz Ergani, Kadriye Yakut Yücel, Büşra Şahin, Cağlayan Ateş, Yıldız Akdaş Reis, Caner Köse, Merve Parlak Özden, Funda Akpınar, Şevki Çelen, Yaprak Üstün
This study aims to investigate the role of the systemic immune-inflammatory index (SII) in inflammation by analyzing SII values by trimester in gestational diabetes mellitus (GDM).
-
Nutrition during pregnancy: Influence on the gut microbiome and fetal development Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-11 Gabriela Barrientos, Francesca Ronchi, Melanie L. Conrad
Pregnancy is a finely tuned process, with the health and well-being of the developing fetus determined by the metabolic status and dietary intake of the mother. The maternal gut microbiome is remodeled during pregnancy, and this, coupled with the maternal nutrient intake during gestation shapes the production of metabolites that can cross the placenta and affect fetal development. As posited by the
-
Insertive vaginal sex is associated with altered penile immunology and enrichment of Gardnerella vaginalis in uncircumcised Ugandan men Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-06 Erin Day, Ronald M. Galiwango, Daniel Park, Sanja Huibner, Maliha Aziz, Aggrey Anok, James Nnamutete, Yahaya Isabirye, John Bosco Wasswa, Deo Male, Godfrey Kigozi, Aaron A. R. Tobian, Jessica L. Prodger, Cindy M. Liu, Rupert Kaul
HIV susceptibility is linked to the penile immune milieu (particularly IL-8 levels) and microbiome. The effects of insertive vaginal sex itself on penile immunology and microbiota are not well described.
-
Oral administration of Bifidobacterium longum ES1 reduces endometrial inflammation in women with recurrent pregnancy loss Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-06 Chiara Tersigni, Greta Barbaro, Roberta Castellani, Marianna Onori, Chiara Granieri, Giovanni Scambia, Nicoletta Di Simone
Over-activation of endometrial inflammasome NALP-3 (Nod-like receptor family pyrin domain containing 3) can be found in recurrent pregnancy loss (RPL) women probably due to leaky gut and passage into circulation of lipopolysaccharides (LPS). Leaky gut can be caused by exposure to gluten in RPL women genetically predisposed to celiac disease, positive for Human Leukocyte Antigen (HLA)-DQ2/DQ8 haplotype
-
Effects of Ureaplasma parvum infection in the exosome biogenesis-related proteins in ectocervical epithelial cells Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-06 Ourlad Alzeus G. Tantengco, Ramkumar Menon
Ureaplasma parvum is a mycoplasma commonly associated with female reproductive pathologies, such as preterm birth and infertility. It can survive intracellularly and utilize exosomes to propagate infection and its virulence factors. This study explored the differential protein composition of exosomes derived from normal and U. parvum-infected cells. We also investigated the impact of U. parvum on exosome
-
Naringenin alleviates the excessive lipid deposition of polycystic ovary syndrome rats and insulin-resistant adipocytes by promoting PKGIα. Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-12-01 Yungai Xiang,Meng Wang,Guo Yu,Lijing Wan,Yuxia Song,Yan Li,Xujing Geng,Li Tan
BACKGROUND Naringenin (NGEN) has anti-inflammatory and anti-diabetic effects. On this basis, this study aims to determine whether NGEN affects insulin resistance (IR) in polycystic ovary syndrome (PCOS). METHODS CCK-8 assay and oil red O staining were used to detect the cytotoxicity of NGEN and lipid production in cells or tissues, respectively. The differentiated mature SW872 cells were treated with
-
UP-regulated levels of sHLA-G in women with a history of RPL in mid-gestation presumably to achieve ongoing pregnancy Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-23 Parveen Jahan, Rashmi Bhuwalka, Mahmooda Begum, Dhatri Madduru, Arif Ahmad, Rajeshwari Bonu
Recurrent Pregnancy Loss (RPL) is a disorder characterized by two or more pregnancy losses within 20th week of gestation. Globally 1–5% of the couples are affected, 50% of these cases are with unknown etiology. HLA-G, an Immuno-modulatory molecule is a non-classical MHC-1 protein, expressed abundantly on extravillous trophoblastic cells, responsible for spiral artery remodeling, maintaining maternal
-
Validation of the Sw71-spheroid model with primary trophoblast cells Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-23 Marina Alexandrova, Diana Manchorova, Yuan You, Antonia Terzieva, Violeta Dimitrova, Gil Mor, Tanya Dimova
Human implantation is a limiting factor for the success of natural and IVF reproduction since about 60% of pregnancy losses occur in the peri-implantation period. The in vitro modeling of human implantation challenges the researchers in accurate recreation of the complex in vivo differentiation and function of human blastocyst in the peri-implantation period. In previous studies, we constructed Sw71-spheroid
-
Characterization of the maternal serum inflammatory profile during pregnancy according to socioeconomic status Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-21 Natalie E. Poliektov, Alexandra D. Forrest, Kirk A. Easley, Alicia K. Smith, Anne L. Dunlop, Martina L. Badell, Vasiliki Michopoulos, Carolynn M. Dude
In pregnancy, lower socioeconomic status (SES) is associated with adverse outcomes, which is partly attributed to chronic inflammation. Our study compared the maternal serum cytokine profiles in patients with low and high SES.
-
Validation of vaginal microbiome proxies for in vitro experiments that biomimic Lactobacillus-dominant vaginal cultures Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-14 Abir Zahra, Ramkumar Menon, Giovana Fernanda Cosi Bento, Jessica Selim, Brandie D. Taylor, Kathleen L. Vincent, Richard B. Pyles, Lauren S. Richardson
The vaginal microbiome includes diverse microbiota dominated by Lactobacillus [L.] spp. that protect against infections, modulate inflammation, and regulate vaginal homeostasis. Because it is challenging to incorporate vaginal microbiota into in vitro models, including organ-on-a-chip systems, we assessed microbial metabolites as reliable proxies in addition to traditional vaginal epithelial cultures
-
Intrauterine perfusion of dexamethasone improves pregnancy outcomes in recurrent reproductive failure patients with elevated uterine natural killer cells. A retrospective cohort study Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-07 Feng Zhang, Zhuran Wang, Ruochun Lian, Lianghui Diao, Yuye Li, Yaya Wu, Tailang Yin, Chunyu Huang
To determine the effect of intrauterine perfusion of dexamethasone (DXM) on pregnancy outcomes in recurrent reproductive failure (RRF) patients with elevated uNK cells.
-
Association of human leukocyte antigen-G and -F with recurrent miscarriage and implantation failure: A systematic review and meta-analysis Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-05 Nana Han, Wanting Xia, Can Zhu, Xuan Zhang, Fan Wang, Zhixing Yin, Qian Zeng
The immune system plays an essential role in embryonic implantation and pregnancy, but the molecular details remain controversial. In the past four decades, human leukocyte antigen (HLA)-G and -F have garnered significant attention.
-
Decreased CD56+CD16-CD94+uNK cells in the mid-luteal phase in women with recurrent implantation failure are associated with IL-15 deficiency Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-11-02 Xin-Xian Zhang, Xiao-Hua Wu
Whether the abnormal development of uterine natural killer (uNK) cells contributes to women with recurrent implantation failure (RIF) remains unclear.
-
Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-31 Sydney E. Parks, Ting Geng, Diana Monsivais
The endometrium is a unique and highly regenerative tissue with crucial roles during the reproductive lifespan of a woman. As the first site of contact between mother and embryo, the endometrium, and its critical processes of decidualization and immune cell recruitment, play a leading role in the establishment of pregnancy, embryonic development, and reproductive capacity. These integral processes
-
Association between VDR genetic polymorphisms and risk of gestational diabetes mellitus in the Chinese population Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-26 Yantuanjin Ma, Yuhang Zhang, Qiuyue He, Tong Xu, Wei Huang, Xingli Deng, Yuan Qian
Abnormal metabolism of vitamin D was the primary mechanism in many pregnancy diseases. Our study was the first to examine the hypothesis that VDR gene polymorphisms contribute to the risk of gestational diabetes mellitus (GDM) in the Chinese population at high altitudes.
-
Interferon-stimulated gene 15 polymorphisms are associated with spontaneous preterm birth in Taiwanese women Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-26 Tzu-Yang Chang, Liang-Kai Wang, Yi-Hsiu Kuo, Chia-Yu Chen, Tun-Wen Pai, Chie-Pein Chen
Immune and inflammatory responses are known to be major causes of preterm birth (PTB). The maternal genetic background plays an important role in the development of PTB. Interferon-stimulated gene 15 (ISG15) is an interferon-induced protein which can modulate immune cell activation and function. We aim to study if polymorphisms in the ISG15 gene are associated with spontaneous PTB (sPTB) risk in Taiwanese
-
METTL3 promotes choriocarcinoma progression by activating the miR-935/GJA1 pathway in an m6A-dependent manner Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-25 Wenzhi Wang, Jianyong Shi, Lei Zheng
The emerging role of microRNA-935 (miR-935) in modulating cancer progression has been recognized. However, its role in regulating choriocarcinoma (CCA) development and progression remains unknown. The present work aims to reveal the effect of miR-935 on CCA cell tumor properties and the related mechanism. The RNA expression of methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
-
The regulation of tolerogenic dendritic cells by a Chinese herb formula improves abortion prone in mice Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-22 Fei Ma, Xiaoyang Feng, Erfeng Wang, Chang Ma, Jiaman Wu, Shan He, Ying Tian, Pingping Qiu, Liya Tan, Jin Liu, Jia Li, Suqin Hu, Pingchang Yang, Yan Ning
Abortion prone (AP) is a common clinical event. The underlying mechanism remains unclear. Traditional Chinese formulas are known to be efficient in the management of abortion. The purpose of this study is to observe the effects of Anzitiaochongtang (AZT), a traditional formulation of Chinese medicine, on improving AP in mice by regulating immune tolerance.
-
Association between torquetenovirus in vaginal secretions and infertility: An exploratory metagenomic analysis Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-20 A. Charlys Da Costa, Pietro Bortoletto, Steven D. Spandorfer, Tania Regina Tozetto-Mendoza, Iara M. Linhares, Maria Cassia Mendes-Correa, Steven S. Witkin
The association of viruses with infertility remains incompletely evaluated.
-
Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-19 Peng-Chao Wang, Zhen-Shan Yang, Xiao-Wei Gu
Decidualization is critical to the establishment of mouse normal pregnancy. The fibroblast-like stromal cells in the process form polyploid multinucleated cells. Aurora kinase B (Aurora B) has previously been shown to regulate polyploidy in various cells. However, whether Aurora B regulates the formation of decidual cell polyploidization and its regulatory mechanisms remain poorly understood.
-
Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-16 Christina Balle, Anna-Ursula Happel, Renee Heffron, Heather B. Jaspan
Until recently, most data regarding the effects of non-barrier contraceptives on the mucosal microbiome have derived from observational studies, which are potentially biased due to behavioral confounders that may mask their true biological effects.
-
Insight into inflammation involvement in varicocele: A narrative review Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-11 Aram Minas, Larissa de Oliveira Rodrigues, Mariana Camargo, Ricardo Pimenta Bertolla
Varicocele is one of the main causes of male infertility. Although the pathophysiology mechanism of varicocele is very well described and understood, there are some unanswered questions that remains unknown. Some studies have previously described the state of testicular inflammation and sperm in animal models, especially the mouse model, and the seminal plasma of men with varicocele, with or without
-
Alterations and potential roles of microbial population of pregnant mouse saliva and amniotic fluid Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-12 Bei Jia, Lijun Tang, Huibing Liu, Yan Zhu, Wenqian Chen, Qian Chen, Jing Li, Mei Zhong, Ailan Yin
Prenatal exposure to intrauterine inflammation (IUI) is a crucial event in PTB pathophysiology. However, the relationship between microflora and PTB is not fully elucidated.
-
Myeloid-derived suppressor cells as a potential biomarker for recurrent pregnancy loss and recurrent implantation failure Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-09 Nabil Subhi-Issa Marin, Eduardo de la Fuente-Muñoz, Raquel Gil-Laborda, Ángela Villegas, Bárbara Alonso-Arenilla, Ignacio Cristóbal, Lydia Pilar-Suárez, Adolfo Jiménez-Huete, Marta Calvo, Beatriz Sarria, Mariló Mansilla-Ruiz, Juliana Ochoa, Miguel Fernández-Arquero, Silvia Sánchez-Ramón
Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an underlying pro-inflammatory state. This study aimed to explore the levels of monocytic-myeloid-derived suppressor cells (M-MDSCs) and regulatory T cells (TReg) in a cohort of RPL and RIF women and their potential contribution
-
Metabolic signature for a dysbiotic microbiome in the female genital tract: A systematic review and meta-analysis. Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-10-01 Biban Gill,Ingrid Schwecht,Nuzhat Rahman,Tushar Dhawan,Chris Verschoor,Aisha Nazli,Charu Kaushic
BACKGROUND The vaginal microbiome (VMB) is a critical determinant of reproductive health, where a microbial shift towards a dysbiotic environment has implications for susceptibility to, and clinical presentation of sexually transmitted infections (STIs). Metabolomic profiling of the vaginal microenvironment has led to the identification of metabolic responses to clinical conditions of dysbiosis. However
-
Impact of bisphenol A on cell viability and inflammatory cytokine production in human cervical epithelial cells Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-28 Ourlad Alzeus G. Tantengco, Manuel S. Vidal, Giovana Fernanda Cosi Bento, Ramkumar Menon
An intact cervix is a barrier that prevents pathogenic bacteria from invading the uterine and amniotic cavity during pregnancy. Its disruption is associated with ascending infection and adverse pregnancy outcomes. This study analyzed the effects of bisphenol A (BPA), a chemical used in plastics manufacturing, on cell death and inflammation in cervical epithelial cells.
-
Association between immunity and different clinical symptoms in patients with polycystic ovary syndrome Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-23 Huan Xiao, Tailang Yin, Lianghui Diao, Yan Zhang, Chunyu Huang
Polycystic ovary syndrome (PCOS) is a disease with endocrine and metabolic disorders. The main symptoms are hyperandrogenemia (HA), insulin resistance (IR), and ovulation disorder. However, the pathogenesis and pathophysiological process of these major symptoms in PCOS are still not well defined. In recent studies, the chronic low-grade inflammatory state has become one of the factors affecting PCOS
-
Association between glycemic control and group B streptococcus colonization among pregnant individuals with pregestational diabetes Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-21 Christine Field, T. Caroline Bank, Colleen K. Spees, Katherine Germann, Mark B. Landon, Steven Gabbe, William A Grobman, Maged M Costantine, Kartik K. Venkatesh
Pregestational diabetes increases the risk of group B streptococcus (GBS) colonization in pregnancy. Whether glycemic control is associated with differences in this risk is unknown. We examined the association between glycemic control and GBS colonization among pregnant individuals with pregestational diabetes.
-
Pro-inflammatory cytokines are modified during the multiplication of Trypanosoma cruzi within the placental chorionic villi and are associated with the level of infection via the signaling pathway NF-κB Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-13 Evangelina Benizio, María José Moreira-Espinoza, María Fernanda Triquell, Luciana Mezzano, Cintia M. Díaz-Luján, Ricardo E. Fretes
Congenital Trypanosoma cruzi (T. cruzi) infection has been associated with changes in the levels of TNF-α and IFN-γ during the pregnancy. Therefore, we propose to study the participation and dynamics of proinflammatory cytokines in the infection process of placental explants infected by T. cruzi in vitro.
-
Pyruvate dehydrogenase kinase 1 regulates the function of human decidual natural killer cells Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-04 Huirong Li, Linghui Cheng, Shiyue Su, Peipei Guo, Zhaolian Wei
Pyruvate dehydrogenase kinase 1 (PDK1) is an important enzyme for immune cell development. However, PDK1's role in human decidual natural killer (dNK) cells remains largely unknown.
-
Role of tumor necrosis factor-alpha -238 G>A promoter region polymorphism on recurrent miscarriage: An association study and meta-analysis Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-03 Neha Sudhir, Mandeep Kaur, Sukhjashanpreet Singh, Archana Beri, Tajinder Kaur, Badaruddoza, Anupam Kaur
Recurrent miscarriage (RM) is defined as the loss of two or more consecutive pregnancies. A functional SNP, -238G>A in the promoter region of TNF-α, affects the gene transcription activity with implications on human pregnancy. Previous limited studies, linking the TNF-α -238 G>A to the risk of recurrent miscarriage have been inconclusive.
-
High prevalence of chronic endometritis is associated with metabolic abnormality and reduced live birth rate among IVF women with non-uniform endometrial echogenicity Am. J. Reprod. Immunol. (IF 3.6) Pub Date : 2023-09-03 Jing Guo, Yuan Li, Shan Liu, Haiying Ren
To assess the prevalence of chronic endometritis (CE) among women with non-uniform endometrial echogenicity, and to evaluate the association between CE and metabolic characteristics as well as pregnancy outcomes in the subsequent frozen–thawed embryo transfer (FET) cycles.