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Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-02-21 Xiao Tian, Jie Wei
ObjectiveWe aimed to explore the effect and potential mechanism of Sestrin 2 (SESN2) in human lens epithelial cells (HLECs).MethodsTo mimic the oxidative stress environment, SAR01/04 cells were treated with 200 μM hydrogen peroxide (H2O2) for 24 h. Cell viability and apoptosis were checked by cell counting kit-8 and flow cytometry. Western blot was taken to check the protein changes of SESN2, B-cell
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Conjunctival and nasal microflora in patients on topical cyclosporine for dry eye Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-02-07 Emine S Elibol, Zafer Habip, Ahmet Elbay, Ahmet Adnan Cırık, Halit Oğuz
Introduction: Dry eye is a common ocular condition causing discomfort and visual disturbances. Anti-inflammatory agents like Cyclosporine A (CsA) are often used in its treatment. However, the impact of CsA on ocular flora remains understudied. This research aimed to evaluate changes in conjunctival and nasal microflora in patients receiving topical cyclosporine for dry eye. Methods: In this cross-sectional
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3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson’s disease models via the cGAS-STING pathway Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-02-05 Yuqian Liu, Ruonan Duan, Peizheng Li, Bohan Zhang, Yiming Liu
Neuroinflammation is crucial in the onset and progression of dopaminergic neuron loss in Parkinson’s disease (PD). We aimed to determine whether 3-N-Butylphthalide (NBP) can protect against PD by inhibiting the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and the inflammatory response of microglia. MitoSOX/MitoTracker/Hoechst staining was used to detect the levels of
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Proposal of pharmacophore model for HIV reverse transcriptase inhibitors: Combined mutational effect analysis, molecular dynamics, molecular docking and pharmacophore modeling study Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-02-01 Azzeddine Annan, Noureddine Raiss, Sanae Lemrabet, Nezha Elomari, El Harti Elmir, Abdelkarim Filali-Maltouf, Leila Medraoui, Hicham Oumzil
Objectives: Antiretroviral therapy (ART) efficacy is jeopardized by the emergence of drug resistance mutations in HIV, compromising treatment effectiveness. This study aims to propose novel analogs of Effavirenz (EFV) as potential direct inhibitors of HIV reverse transcriptase, employing computer-aided drug design methodologies. Methods: Three key approaches were applied: a mutational profile study
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CXC ligand 13 orchestrates an immunoactive microenvironment and enhances immunotherapy response in head and neck squamous cell carcinoma Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-01-22 Xiaohu Lin, Xiaomei Zhao, Yiming Chen, Rong Yang, Zhenlin Dai, Wei Li, Chengzhong Lin, Wei Cao
Objectives: This study aims to systematically explore the role of chemokine CXC ligand 13 (CXCL13) in head and neck squamous cell carcinoma (HNSCC). Methods: The Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases provided the RNA-seq data for cancer and normal tissues, respectively. Gene set enrichment analysis was applied to search the cancer hallmarks associated with CXCL13
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Activating transcription factor 3 is a new biomarker correlation with renal clear cell carcinoma progression Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-01-22 Zhicong Yang, Yongwang Hou, Jingqi Li, Dandan Xu, Zhichao Yang, Xinsheng Wang
Background: Clear cell renal cell carcinoma (ccRCC) is the most invasive type of cancer, with a high risk of metastasis and recurrence. Therefore, there is an urgent need to identify novel prognostic predictors and therapeutic targets of ccRCC. Activating transcription factor 3 (ATF3), a tumor oncogene or repressor, has rarely been examined in ccRCC. In the present study, we comprehensively elucidate
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Antidiabetic and antioxidant potential of Crocin in high-fat diet plus streptozotocin-induced type-2 diabetic rats Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-01-18 Syed Mohammed Basheeruddin Asdaq, Basheerahmed Abdulaziz Mannasaheb, Raha Orfali, Ibrahim Ahmed Shaikh, Ahmed Alshehri, Adel Alghamdi, Meshal Mohammed Alrashdi, Moneer E Almadani, Faisal Mohammad Ali Abdalla
ObjectivesCrocin, the principal water-soluble active constituent of saffron, possesses numerous pharmacological activities. The present investigation examined the potential antidiabetic and antioxidant characteristics of Crocin in rats with type-2 diabetes by administering it orally and intraperitoneally (i.p.).MethodsAfter 2 weeks of a high-fat diet, streptozotocin (STZ) (i.p., 40 mg/kg) was administered
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The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-01-13 Natalia Ukleja-Sokołowska, Kinga Lis, Małgorzata Graczyk, Marcelina Bartuzi, Zbigniew Bartuzi
The symptoms of celery allergy are mainly presented as oral allergy symptom, but there are several case reports of patients who experienced anaphylaxis. Defensin (Api g 7), as a novel allergen in celery root, was described in 2022 r. The female patient had a history of several episodes of dyspnea and cough, associated with ingestion of spice mixes containing dried celery. Up to the point of hospitalization
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The hepatotoxicity of γ-radiation synthesized 5-fluorouracil nanogel versus 5-fluorouracil in rats model Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2024-01-11 Wael EM Barakat, Fatma SM Moawed, Esraa SA Ahmed, Omayma AR Abo-Zaid
Introduction: The clinical use of 5-fluorouracil (5-FU), a routinely used chemotherapy medication, has a deleterious impact on the liver. Therefore, it is necessary to find a less harmful alternative to minimize liver damage. This study was designed to see how 5-fluorouracil nanogel influenced 5-FU-induced liver damage in rats. Methods: To induce liver damage, male albino rats were injected intraperitoneally
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Curcumin nanocapsules effect in apoptotic processes, gene expression, and cell cycle on Hep-G2 cell lines Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-05-16 Mahmoud Moawad, Ghada M Nasr, Afaf S Osman, Emad S Shaker
ObjectivesCurcumin has antioxidant and antiproliferative properties, and its therapeutic effect must be considered. Nanocurcumin capsules showed a potential increase against in vitro biological can...
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Expression profile of cytokines and chemokines in a mouse high-altitude cerebral edema model Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-05-15 Zibi Shi, Xiufang Jiang, Yanan Geng, Xiangpei Yue, Jiayue Gao, Xiang Cheng, Ming Zhao, Lingling Zhu
IntroductionHigh-altitude cerebral edema (HACE) is considered to be the end-stage of acute mountain sickness (AMS); however, its pathophysiological mechanism remains unknown. Increasing evidences s...
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Dose-dependent effects of taurine against testicular damage in a streptozotocin-induced type 1 diabetes mellitus rat model Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-26 Ahmed H ElBanna, Afaf S. Osman, Amira Hossny, Hossny ElBanna, Fatma I. Abo El-Ela
ObjectivesTesticular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine’s possible mechanisms and protective effects against testicula...
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Immune system modulation by low-dose ionizing radiation-induced adaptive response Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-19 Soha M Hussien, Engy R Rashed
Objective:Hormesis or low-dose ionizing radiation is known to induce various biological responses, a subcategory of which is the adaptive response, which has been reported to protect against higher...
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Identification of an immune-related genes signature to predict risk of recurrence for patients with laryngeal squamous cell carcinoma Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-19 Xiu Hong, Yang Li, Qian Lv, Jun An, Ying Liu, Xiuli Wang, Rui Li, Yuqiang Hu, Bing Liu
ObjectiveNumerous studies indicate that immune-related genes (IRGs) are closely related to tumorigenesis and tumor progression. We aimed to establish a robust IRGs-based signature to predict risk o...
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Construction and evaluation of an aging-associated genes-based model for pancreatic adenocarcinoma prognosis and therapies Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-18 Junjie Zhao, Kelei Guan, Jiyuan Xing
Objectives: Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor. Despite extensive research, the precise role of aging-related genes in the initiation, microenvironment regulation, and pro...
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The Nose and Paranasal Sinuses Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 A. Varricchio, F. Avvisati, A.M. Varricchio, G. Tortoriello, G. Ciprandi
The airways should be considered as a functional unit. Indeed, disorders involving the upper respiratory tract (URT) spread to the lower respiratory tract (LRT). Modern functional anatomy divides U...
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Functional Anatomy of the Eustachian Tube Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 E. Cunsolo, D. Marchioni, G. Leo, C. Incorvaia, L. Presutti
The Eustachian tube (ET) is divided in 3 portions: a bony portion, a cartilaginous portion, and a junctional portion. From an anatomical-functional point of view, the bony portion of ET is the regi...
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Upper Respiratory Tract Infections and Atopy Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 F. Pollini, C. Capristo, A.L. Boner
Upper respiratory tract infections and allergic diseases are particularly common in children. It seems that atopy may predispose to more severe symptoms during infections and may facilitate togethe...
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The Infections of the Upper Respiratory Tract in Children Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 F. Bonsignori, E. Chiappini, M. De Martino
Upper respiratory tract infections in children are common and usually self-limiting conditions, which include acute otitis media (AOM), acute rhinosinusitis (ARS), and acute pharyngitis (AP). Manag...
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The Clinical Spectrum of Rhinosinusitis in Children Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 G. Leo, C. Incorvaia
Rhinosinusitis is an extremely common disease that is often underreported, especially in children. Its clinical spectrum includes acute rhinosinusitis (ARS) — which may present in the forms of ARS ...
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Rhinosinusitis and Asthma Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 G.L. Marseglia, S. Caimmi, A. Marseglia, D. Poddighe, M. Leone, D. Caimmi, G. Ciprandi, A.M. Castellazzi
Chronic rhinosinusitis and asthma are not simply localized disease processes but part of a systemic inflammatory disease affecting the respiratory tract. There is a correlation between severity of ...
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The Immunity of Upper Airways Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 C. Canessa, S. Vierucci, C. Azzari, A. Vierucci
A specialized immune system, called the nasopharynx-associated lymphoid tissue (NALT), is located on the mucosal surface of upper airways and is composed of both innate and specific immunity elemen...
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Risk Factors for Upper Airway Diseases Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 M. Duse, L. Leonardi, A.M. Zicari, G. De Castro, L. Indinnimeo
Upper respiratory infection is the most common reason for seeking medical care for children. Recurrent viral respiratory infections and subsequent complications are a burden for children, their fam...
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Insights into Infectious Otitis Media Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 P. Marchisio, S. Bianchini, P. Capaccio, S. Esposito, M. Fusi, E. Nazzari, S. Torretta, N. Principi
Otitis media is a multifactorial disease. It represents a major public health burden, as it is the most common diagnosis in children and is characterized by both immediate and long-term morbidity. ...
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Role of Nasal Cytology Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-13 M. Gelardi, M.L. Fiorella, C. Russo, R. Fiorella, G. Ciprandi
Nasal cytology represents a valid method in the differential diagnosis of allergic and non-allergic nasal diseases, as it is simple, safe, non-invasive, cost-effective, and easy to perform both in ...
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Experimental study on the effect of luteolin on the proliferation, apoptosis and expression of inflammation-related mediators in lipopolysaccharide-induced keratinocytes Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-06 Xinpei Wang, Yue Yao, Yexian Li, Shujing Guo, Yanjia Li, Guoqiang Zhang
ObjectiveThis study aimed at exploring the effects of luteolin on psoriasis-like cell model proliferation, apoptosis regulation and the expression of inflammation-related mediators.MethodsA Cell Co...
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Smoking-related epigenetic modifications are associated with the prognosis and chemotherapeutics of patients with bladder cancer Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-04-03 Ya Ling, Jindong Li, Lijuan Zhou
ObjectiveEpidemiologic studies have linked smoking to various malignancies, including bladder cancer, but its underlying biological functions remain elusive. Currently, we aimed to identify the smo...
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Patterns of cytokine and chemokine expression in peripheral blood of patients with COVID-19 associated with disease severity Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-03-16 Iva Trifonova, Kim Ngoc, Maria Nikolova, Radoslava Emilova, Yana Todorova, Teodora Gladnishka, Iva Christova
ObjectivesCytokine dysregulation has been proposed as one of the main culprits for severe COVID-19 and poor prognosis. We examined the parallel presence of lymphopoietic, proinflammatory, Th1, Th2,...
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Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-03-06 Ann Erlandsson, Marie Lundholm, Johan Watz, Anders Bergh, Elitsa Petrova, Farhood Alamdari, Thomas Helleday, Sabina Davidsson, Ove Andren, Firas Tarish
ObjectivesAndrogen deprivation therapy (ADT) has long been a cornerstone in treatment of advanced prostate cancer (PCa), and is known to improve the results of radiotherapy (RT) for high-risk disea...
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Study of the possible effect of sacubitril/valsartan combination versus valsartan on the cognitive function in Alzheimer’s disease model in rats Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-03-06 Abdallah Salah El-din Hussein, Rahma Kamal El-Din Abou-El Nour, Omayma A Khorshid, Afaf S Osman
Objectives: Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disorder. The proportion of elderly individuals at risk for AD and cardiovascular problems increases by raisin...
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Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-27 Yong-Bo Feng, Ling Chen, Fu-Xing Chen, Yang Yang, Guo-Hua Chen, Zhong-Hai Zhou, Chun-Fang Xu
Apigenin is a kind of flavonoid with many beneficial biological effects. It not only has direct cytotoxicity to tumor cells, but also can boost the antitumor effect of immune cells by modulating im...
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Role of the regulation of mesenchymal stem cells on macrophages in sepsis Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-25 Jie Xing, Rui Wang, Fengqi Cui, Linlin Song, Quanlin Ma, Huiyun Xu
Sepsis is a common clinical critical disease with high mortality. The excessive release of cytokines from macrophages is the main cause of out-of-control immune response in sepsis. Mesenchymal stem...
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Effect of icariin on the H2O2-induced proliferation of mouse airway smooth muscle cells through miR-138-5p regulating SIRT1/AMPK/PGC-1α axis Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-10 Yu-fang Huang, Guo-chun Ou, Shou-hong Ma, Ming-wei Liu, Wen Deng
Icariin exerts antioxidative and anti-inflammatory effects and is used in the treatment of bronchial asthma. However, the specific modes of action are uncertain. In this study, we investigated whet...
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Research and analysis on computed tomography signs and clinical characteristics of chronic duodenal papilla mucositis and duodenal papillary carcinoma Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-10 Wenyan Wei, Weixing Mo, Ning Wang, Qinghai Li
Objective: To investigate the computed tomography (CT) findings of chronic duodenal papilla mucositis and duodenal papillary carcinoma, and provide more imaging information for early diagnosis of d...
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Effectiveness and safety of rectal dexibuprofen versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants with gestational age<34 weeks: A pilot study Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-06 Jing-jing Pan, Yang Yang, Shu-dong Cui, Xiao-qing Chen, Xiao-guang Zhou
This pilot study aimed to explore the effectiveness and safety of dexibuprofen suppository in the treatment of PDA in preterm infants. Preterm infants with gestational age <34 weeks and color Doppl...
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Crosstalk between miR-146a and pro-inflammatory cytokines in patients with systemic lupus erythematosus Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-05 Basima A El-Akhras, Roba M Talaat, Samir A El-Masry, Iman H Bassyouni, Ibrahim H El-Sayed, Yasser BM Ali
microRNA-146a (miR-146a) plays an essential role in immune anomalies and organ injury of systemic lupus erythematosus (SLE) by regulating the disease’s inflammation and complications. Here, we anal...
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Resveratrol suppresses lipopolysaccharide-mediated activation of osteoclast precursor RAW 264.7 cells by increasing miR-181a-5p expression Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-02-01 Hai-Yan Xue, Ming-Wei Liu, Guang Yang
Resveratrol (Res) has anti-inflammation and antiosteoporosis functions. We evaluated the effect of Res on osteoclast differentiation by releasing inflammatory cytokines from osteoclast precursor RA...
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High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-30 Shaimaa M Kamel, Mervat E (Mervat I ) Abdel Azeem (Abd Elazeem), Rabab A Mohamed, Mahmoud M Kamel, Enas A Abdel Aleem (Abdelaleem)
Objectives: Leptin and adiponectin are adipose-derived immune modulators (adipokines) that may contribute to SLE pathology and symptoms. This study aimed to evaluate the associations of serum adipo...
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Encephalitis lethargica. What is still wrong? Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-30 A Di Vito, A Donato, J Bria, F Donato, G Donato
Encephalitis lethargica developed in epidemic from 1919 to 1926 in Europe and throughout the world. From the clinical point of view, the disturbances of consciousness and alertness and the possible...
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Changes in breast cancer staging trends among Egyptian women after COVID-19: A retrospective single-center study Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-17 Mostafa H Abd El Wahab, Ahmed H Ibrahim, Omar Gado, Ali M Bahbah, Waleed Fadlalla, Sherihan Fakhry, Mona M Mamdouh, Mahmoud M Kamel, Inas Moaz, Ahmed Rabea, Amany M Helal
ObjectivesSince being declared a global pandemic, the SARS-CoV-2 virus had a significant impact on the entire globe. The pandemic has placed a heavy burden on healthcare systems worldwide, and canc...
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Antiproliferative and apoptotic effects of conditioned medium released from human amniotic epithelial stem cells on breast and cervical cancer cells Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-13 Ameneh Jafari, Hassan Niknejad, Mostafa Rezaei-Tavirani, Ramin Sarrami-Forooshani, Samira Gilanchi, Zahra Jafari
IntroductionHuman amniotic membrane (hAM) and its cells have been proposed for several clinical applications, including cancer therapy. However, reports on the anticancer effects of human amniotic ...
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Serum Tryptase in Allergic Rhinitis: Effect of Cetirizine Treatment Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-08 G. Bruno, P. Andreozzi, L. Magrini, G. Santangelo, U. Graf, A. Angelino
Activated mast cells release a large range of potent mediators of allergic inflammation, including proteases. The tryptase serum levels were evaluated in 13 subjects suffering from allergic perenni...
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Boswellic acid coated zinc nanoparticles attenuate NF-κB-mediated inflammation in DSS-induced ulcerative colitis in rats Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-04 Eman S Abou Zaid, Somya Z Mansour, Sawsan M El-Sonbaty, Fatma SM Moawed, Eman I Kandil, Riham Abdel-Hamid Haroun
IntroductionUlcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, and until now therapeutic agents for UC still cannot exert satisfied effects. Therefore, this study aimed t...
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Potential diagnostic role of circulating MiRNAs in colorectal cancer Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-04 Dina A Abo-elela, Ahmed MH Salem, Menha Swellam, Marwa GA Hegazy
ObjectivesColorectal cancer (CRC) is the third most common and fourth most deadly cancer worldwide despite its various screening method. Thus, the search for novel and better markers is continuous....
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Neutrophil–lymphocyte ratios in blood to distinguish children with asthma exacerbation from healthy subjects Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-04 Ruilin Pan, Yaning Ren, Qingqing Li, Xuming Zhu, Jian Zhang, Yubao Cui, Hao Yin
ObjectiveAirway inflammation is a prominent feature of asthma and may play an important role in disease pathophysiology. Despite the increasing incidence of asthma worldwide, reliable diagnostic bi...
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Erastin induces ferroptosis in cervical cancer cells via Nrf2/HO-1 signaling pathway. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Xiaoning Wei,Qiaoqiao Huang,Jinbing Huang,Li Yu,Junying Chen
OBJECTIVE Our research aims to assess the influence of erastin, a ferroptosis-inducing agent, on cervical cancer cells. INTRODUCTION Cervical cancer is a prevalent malignancy in females. Dysregulation of ferroptosis, a form of cell demise reliant on iron, is implicated in several cancers. METHODS The effect of erastin on HeLa and SiHa was detected by transwell assay, scratch test, and colony formation
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Identification of key proteins as potential biomarkers associated with post-infarction complications in diabetics. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Wei Wu,Li Yan,Xiao-Fei Yuan,Lu Wang,Yu Zhang,Rong-Xiang Tu,Jiang-Qi Pan,Lu Yin,Zhi-Ru Ge
Background: The ability of transcriptome analysis to identify dysregulated pathways and outcome-related genes following myocardial infarction in diabetic patients remains unknown. The present study was designed to detect possible biomarkers associated with the incidence of post-infarction complications in diabetes to assist thedevelopment of novel treatments for this condition.Methods: Two gene expression
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Discovering KYNU as a feature gene in hidradenitis suppurativa. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Chen Liang,Yue Yu,Qinyu Tang,Liangliang Shen
BACKGROUND Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin condition characterized by nodules, abscesses, and fistulae in skin folds. The underlying pathogenesis of HS remains unclear, and effective therapeutic drugs are limited. METHODS We acquired mRNA expression profiles from the Gene Expression Omnibus (GEO) database and conducted differential expression analysis between control
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Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Asmaa Ali,Ahmed Samir Abdelhafiz,Mai M Saleh,Heba Salem,Mohammed A Rakha,Seham Ezzat
Objectives: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common pulmonary diseases. The concomitant association of Obstructive Sleep Apnea (OSA) and COPD is known as the Overlap Syndrome (OS). This study aimed to identify markers for predicting OS, among routine laboratory tests, including differential blood counts.Methods: One hundred twenty-five patients with exacerbated COPD were
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Steroid initiation timing and outcome of coronavirus disease 2019 patients: A multicenter, retrospective, observational study. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Ryu Sugimoto,Tsuneaki Kenzaka,Ayako Mikami,Nobuaki Matsunaga,Takayuki Akiyama,Norio Ohmagari,Hogara Nishisaki
Objectives: Dexamethasone's (DEXA) beneficial effect on survival when administered to critically ill patients with coronavirus disease 2019 (COVID-19) has been documented in randomized trials and meta-analyses. Here, we conducted this study to clarify the association between time from COVID-19 onset to steroid initiation and mortality and to examine the factors underlying these results.Methods: This
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Bibliometric and visual analyses of trends in the field of T cell exhaustion research: Findings from 2000 to 2022. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Ziling Liu,Huan Wan,Yao Tan,Deshuang Li,Jianguo Huang,Chuanhe Zhang,Fangyuan Liu,Bo Qin
BACKGROUND T cell exhaustion refers to a state wherein T cells become less functional as a result of their prolonged exposure to cognate antigens. A wealth of T cell exhaustion-focused research has been conducted in recent decades, transforming the current understanding of this biologically relevant process. However, there have not been any comprehensive bibliometric analyses to date focused on clarifying
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Correlation analysis between cytokines' profile, autoimmune antibodies and the duration of type 1 diabetes: A case control study in a specialized children's centre in Riyadh. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Mohammed Al-Dubayee,Amir Babiker,Abdulaziz Alkewaibeen,Abdulrahman Alkhalifah,Tammam Alanazi,Maysa Nogoud,Anas Alotaibi,Faisal Alotaibi,Firas Almetairi,Mohammed A Alrowaily,Emad Masuadi,Amre Nasr
OBJECTIVE The aim of this study was to investigate the role of cytokines in children with T1D living in Saudi Arabia and their correlation with disease duration and autoimmune antibody markers. METHODS A case-control study was conducted in the endocrine clinic of King Abdullah Specialized Children's Hospital in Riyadh. A total of 274 T1D and healthy control children were enrolled in the study. 5 mL
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Identification and development of TP53 mutation-associated Long non-coding RNAs signature for optimized prognosis assessment and treatment selection in hepatocellular carcinoma. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Chenghao Chu,Daoli Liu,Duofa Wang,Shuangjiu Hu,Yongwei Zhang
BACKGROUND The TP53 gene is estimated to be mutated in over 50% of tumors, with the majority of tumors exhibiting abnormal TP53 signaling pathways. However, the exploration of TP53 mutation-related LncRNAs in Hepatocellular carcinoma (HCC) remains incomplete. This study aims to identify such LncRNAs and enhance the prognostic accuracy for Hepatoma patients. MATERIAL AND METHODS Differential gene expression
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Renal venous malformation misdiagnosed as carcinoma: A report of one case and the review of literature. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Xinchun Zhang,Ning Wang,Bingkui Yang
The present study reports the clinical data of a patient with renal venous malformation misdiagnosed as carcinoma. CT revealed hematocele in the left renal pelvis and ureter. CTU: the left renal pelvis and calyces showed a slightly high density shadow, a size of about 2.6 cm*1.5 cm, and mild-to-moderate enhancement was found at the edge of the lesion. Enhanced MR showed that irregular mass abnormal
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Novel anti-amyloid-beta (Aβ) monoclonal antibody lecanemab for Alzheimer's disease: A systematic review. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Selia Chowdhury,Nurjahan Shipa Chowdhury
BACKGROUND Lecanemab is the latest monoclonal antibody that targets beta-amyloid approved exclusively for treatment of Alzheimer's disease with mild cognitive impairment or mild dementia. This article aims to provide a systematic review of the efficacy, and safety of lecanemab in slowing clinical decline in Alzheimer's disease. METHODS A comprehensive search of various databases, including the National
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Inhibition of GPR30 sensitized gefitinib to NSCLC cells via regulation of epithelial-mesenchymal transition. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Xiaomin Yang,Hongyan Jiang,Jiang Ning,Shufen Zhang,Ying Cai,Liang Wang,Jinsong Yang,Guodong Xu,Wei Chen,Jianfei Wang
Introduction: G-protein coupled receptor 30 (GPR30) is associated with cell metastasis and drug resistance in many different cancer cells. The present study aimed to reveal the sensitivity of GPR30 to gefitinib in non-small cell lung cancer (NSCLC) cells.Methods: Cell viability and proliferation were detected using cell counting kit 8 and 5-ethynyl-2'-deoxyuridine assays, respectively. Western blotting
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Analysis of mitochondrial function in lymphocytes obtained from COVID-19 patients. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Zhi He,Jing-Jing Liu,Shao-Lei Ma
OBJECTIVES There is a significant decline in the lymphocyte subset counts in the peripheral blood of COVID-19 patients. However, the mitochondrial function of lymphocytes obtained from COVID-19 patients has rarely been studied. METHODS A case-control study was conducted in 115 COVID-19 patients and 50 healthy controls from December 2022 to February 2023. The extent of lymphocytic mitochondrial damage
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PKNOX1 acts as a transcription factor of DHH and promotes the progression of stomach adenocarcinoma by regulating the Hedgehog signalling pathway. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Bing Liu,Siwei Zhao,Liqing Liu
BACKGROUND This study explored the effects and potential mechanism by which PBX/knotted 1 homeobox 1 (PKNOX1) may exacerbate stomach adenocarcinoma (STAD). METHODS For the in silico analysis, we examined TCGA-PKNOX1 expression using the UALCAN website, as well as its expression patterns in the GSE172032 and GSE174237 datasets, obtained from the GEO database. The associated patient survival curves,
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The impact of hepatitis B virus and hepatitis C virus infections in patients with Hodgkin's and non-Hodgkin's lymphoma. Int. J. Immunopathol. Pharmacol. (IF 3.5) Pub Date : 2023-01-01 Dalia Y Kadry,Mostafa A Elbahnasawy,Mohamed Tm Mansour,Omnia K El Gebaly,Hala Aziz,Mahmoud M Kamel,Ahmed S Abdel-Moneim,Samah Radwan
BACKGROUND This study aimed to determine the prevalence of HCV and occult HBV among newly diagnosed pre-treatment Egyptian lymphoma patients and evaluate patients' outcomes based on the presence of the viral infections. METHODS The study included 80 therapy-naïve lymphoma patients including 71 non-Hodgkin lymphoma (NHL) and 9 Hodgkin lymphoma disease (HD) in addition to 100 healthy volunteers. HBV