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Physiological concentrations of short-chain fatty acids induce the formation of neutrophil extracellular traps in vitro Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-12-29 Liliana Íñiguez-Gutiérrez; Lucila A Godínez-Méndez; Mary Fafutis-Morris; Jorge R Padilla-Arellano; Alfredo Corona-Rivera; Miriam Ruth Bueno-Topete; Óscar A Rojas-Rejón; Vidal Delgado-Rizo
Neutrophils represent the first line of host cellular defense against various pathogens. The most recently described microbicidal mechanism of these cells is the release of neutrophil extracellular traps (NET). Currently, a wide range of chemical and biological stimuli are known to induce this response; however, the effect of short-chain fatty acids (SCFAs) on the induction of NET is still unknown
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Sequential CD38 monoclonal antibody retreatment leads to deep remission in a patient with relapsed/refractory multiple myeloma Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-12-23 Maximilian Johannes Steinhardt; Xiang Zhou; Franziska Krummenast; Katharina Meckel; Katharina Nickel; David Böckle; Janin Messerschmidt; Sebastian Knorz; Alexander Dierks; Anke Heidemeier; Constantin Lapa; Hermann Einsele; Leo Rasche; Klaus Martin Kortüm
We report on a currently 76-year-old female patient with relapsed/refractory (RR) multiple myeloma (MM) treated at our institution. This patient had received six lines of therapy including tandem autologous stem cell transplant, proteasome inhibitor, immunomodulatory drugs and CD38 antibody MOR202. At the last relapse, she progressed during treatment with pomalidomide and MOR202. In an individualized
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Severe anaphylactic shock after anesthesia induction: An unusual initial manifestation of Churg-Strauss syndrome Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-12-07 Aikaterini Melemeni; Aliki Tympa Grigoriadou; Stavroula Karachanidi; Athanasia Tsaroucha
Churg-Strauss syndrome or eosinophilic granulomatosis with polyangiitits (EGPA) is a rare multisystem disorder. A case of anaphylactic shock after induction of anesthesia, as the initial clinical presentation of Churg-Strauss syndrome in a 15-year-old girl is reported. It is extremely rare to see pediatric patients with previous perioperative anaphylaxis receiving future anesthesia; a multidisciplinary
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Halofuginone functions as a therapeutic drug for chronic periodontitis in a mouse model Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-12-01 Jiang Wang; Bo Wang; Xin Lv; Yingjie Wang
Periodontitis is an inflammatory disease caused by host immune response, resulting in a loss of periodontium and alveolar bone. Immune cells, such as T cells and macrophages, play a critical role in the periodontitis onset. Halofuginone, a natural quinazolinone alkaloid, has been shown to possess anti-fibrosis, anti-cancer, and immunomodulatory properties. However, the effect of halofuginone on periodontitis
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Nickel allergy in lipid transfer protein sensitized patients: Prevalence and clinical features Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-11-26 Angela Rizzi; Raffaella Chini; Riccardo Inchingolo; Valentina Carusi; Franco Pandolfi; Antonio Gasbarrini; Eleonora Nucera
Nickel (Ni), the main responsible for allergic contact dermatitis worldwide, is also involved in systemic condition called “Systemic Nickel Sulfate Allergy Syndrome (SNAS).” Likewise, IgE-mediated reactivity to Lipid Transfer Protein (LTP) represents the main cause of primary food allergy in adults of Mediterranean countries. We evaluated the prevalence of SNAS in LTP allergic patients and investigated
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Aberrant miR-219-5p is correlated with TLR4 and serves as a novel biomarker in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-11-25 Yunxiang Dai; Xia Liu; Yuming Gao
This study aimed to investigate the clinical significance of serum microRNA-219-5p (miR-219-5p) in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat (PQ) poisoning, and its correlation with Toll-like Receptor 4 (TLR4). Luciferase reporter assay was used to investigate in vitro the correlation of miR-219-5p with TLR4. Serum miR-219-5p levels were evaluated by quantitative
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Candesartan modulates microglia activation and polarization via NF-κB signaling pathway Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-11-25 Shuyan Qie; Yuanyuan Ran; Xiaosheng Lu; Wei Su; Wei Li; Jianing Xi; Weijun Gong; Zongjian Liu
Microglia are diverse cells that acquire different functional phenotypes in response to microenvironment in which they reside. Several transcriptional regulators have been identified that regulate different microglia phenotypes. They are mainly stimulated into two opposing phenotypes, classically (M1) and alternatively (M2) phenotype. Regulating microglia polarization from M1 to M2 state has been suggested
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LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-11-25 Li Jiang; Mengmeng Zhang; Sixue Wang; Yuzhen Xiao; Jingni Wu; Yuxin Zhou; Xiaoling Fang
The current study intended to explore the interaction of the long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) under the background of competitive endogenous RNA (ceRNA) network in endometriosis (EMs). The differentially expressed miRNAs (DEmiRs), differentially expressed lncRNA (DELs), and differentially expressed genes (DEGs) between EMs ectopic (EC) and eutopic (EU) endometrium
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Effect of norepinephrine combined with sodium phosphocreatine on cardiac function and prognosis of patients with septic shock Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-11-18 Dawei Kang; Jian Yu; Jiading Xia; Xiuhua Li; Huarong Wang; Yanjun Zhao
Septic shock (SS) leads to a high mortality rate for sepsis patients. Norepinephrine (NE) is a preferred vasoactive agent in SS treatment. This study aimed to assess the effects of NE at different administration time and NE combined with SP treatment on the cardiac function and prognosis of SS. SS patients received NE treatment at different administration time and NE combined with SP treatment were
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Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-30 Rabia Zahid; Muhammad Akram; Ejaz Rafique
Polycystic kidneys disease refers to cyst(s) formation in kidneys with severe consequences of end stage renal disease thus have higher mortality. It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) with prevalence rates of 1/1000 and 1/40,000 respectively. Dominant forms presenting in later (>30) while
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MicroRNA-301a inhibition enhances the immunomodulatory functions of adipose-derived mesenchymal stem cells by induction of macrophage M2 polarization Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-29 Li-Wen Hsu; Kuang-Tzu Huang; Toshiaki Nakano; King-Wah Chiu; Kuang-Den Chen; Shigeru Goto; Chao-Long Chen
MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a significant role in biological processes in various cell types, including mesenchymal stem cells (MSCs). However, how miRNAs regulate the immunomodulatory functions of adipose-derived MSCs (AD-MSCs) remains unknown. Here, we showed that modulation of miR-301a in AD-MSCs altered macrophage polarization. Bone marrow (BM)-derived macrophages
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Effects of polyclonal activators on cell differentiation and cytokine production of cultured invasive breast carcinoma of no special type, their association with tumour histopathological parameters and lymph node metastasis Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-25 Alexander Autenshlyus; Sergey Arkhipov; Elena Mikhailova; Igor Marinkin; Nikolay Varaksin; Valentin Vavilin; Vyacheslav Lyakhovich
Currently, a number of promising strategies and approaches to cancer treatment include differentiation therapy. However, theoretical and methodological foundations of this field are not yet well developed. The objective of this study was to determine the effects of a mixture of polyclonal activators (PAs; phytohaemagglutinin, concanavalin A and lipopolysaccharide) on cytokine production by biopsy samples
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KCNQ1OT1 accelerates gastric cancer progression via miR-4319/DRAM2 axis Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-25 Jijun Wang; Fan Wu; Yaoyao Li; Lei Pang; Xiaohong Wang; Guimei Kong; Tong Zhang; Duonan Yu
Introduction: This work was to explore the connection of KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) and microRNA-4319 (miR-4319), and to investigate the associated underlying mechanisms in gastric cancer (GC) progression. Methods: Quantitative real-time PCR was performed to measure KCNQ1OT1, miR-4319 and DNA-damage regulated autophagy modulator 2 (DRAM2) expression levels in GC cells.
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The probiotic Bifidobacterium in the management of Coronavirus: A theoretical basis Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-25 Hüseyin S Bozkurt; Eamonn MM Quigley
COVID-19 is a viral pandemic that primarily manifests with respiratory distress but may also lead to symptoms and signs associated with the gastrointestinal tract. It is characteristically associated with a hyper-immune response, also referred to as a ‘cytokine storm’. Probiotics are living microorganisms that have been shown to have positive effects on immune response in man with some bacteria; some
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Frequency of CD4+ regulatory T cells, CD8+ T cells, and human papilloma virus infection in Egyptian Women with breast cancer Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-25 Amany M Tawfeik; Ahmed Mora; Ahmed Osman; Manar M Moneer; Nabila El-Sheikh; Mohamed Elrefaei
Several subsets of regulatory CD4+ T cells (CD4+ Tregs) have been described in peripheral blood and tumor microenvironment of breast cancer (BC) patients and may play a role in the progression of BC. High-risk human papilloma virus (HR-HPV) has a causal role in cervical, head, and neck tumors but the role of HR-HPV in evoking neoplasia in BC is still unclear. In this study we assessed the prevalence
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Use of zebrafish larvae lateral line to study protection against cisplatin-induced ototoxicity: A scoping review Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-21 Ewa Domarecka; Magda Skarzynska; Agnieszka J Szczepek; Stavros Hatzopoulos
Aim: The present review aimed to consolidate and analyze the recent information about the use of zebrafish in studies concerning cisplatin-induced ototoxicity and otoprotection. Material and methods: The PubMed, Web of Science, and Scopus databanks were searched using the following MESH terms: zebrafish, cisplatin, ototoxicity. The identified publications were screened according to inclusion and exclusion
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Immune system changes during COVID-19 recovery play key role in determining disease severity Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-19 Farshid Fathi; Ramin Sami; Samaneh Mozafarpoor; Hossein Hafezi; Hossein Motedayyen; Reza Arefnezhad; Nahid Eskandari
Coronavirus disease 2019 (COVID-19), an acute respiratory infection, is largely associated with dysregulation and impairment of the immune system. This study investigated how the immune system changes were related to disease severity in COVID-19 patients. The frequencies of different immune cells and levels of pro- and anti-inflammatory cytokines in whole blood of participants were determined by flow
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Occult hepatitis C virus infection in patients with malignant lymphoproliferative disorders Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-13 Abeya A Lotfi; Asmaa E Mohamed; Nahela A Shalaby; Deena S Eissa; Ehab El-Dabaa; Ayman M Sallam; Mahmoud M Kamel; Hisham Abdelaziz; Amal M El-Afifi; Ahmed S Abdel-Moneim
Despite the link between HCV and malignant lymphoproliferative disorders has been established, the association between occult hepatitis C virus infection and malignant lymphoproliferative disorders remains obscure. The present study intended to identify the possible association between occult HCV infection and malignant lymphoproliferative disorders. Newly diagnosed patients with LPDs were screened
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Childhood atopic dermatitis as a precursor for developing attention deficit/hyperactivity disorder Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-13 Yang-chun Xu; Jin-peng Wang; Wen-jing Zhu; Ping Li
Atopic dermatitis (AD) is a skin disease characterized by chronic inflammatory condition that shows hallmark presentations in terms of sleep disturbances, pruritus, and psychological stress, and an association with increased attention deficit/hyperactivity disorder (ADHD) risk. A number of studies have suggested for the co-occurrence of the two diseased conditions. In terms of global prevalence, AD
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Cationic drugs and COVID-19 Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-13 Oreste Vittore Brenna; Sara Torretta; Lorenzo Pignataro; Federica Di Berardino
Given the sharp spreading of COVID-19 pandemic all around the world, our attention was brought to consider that that many cationic drugs (i.e. those characterized by the presence, at physiological pH value, of one or more cationic groups, both primary, secondary, tertiary and guanidinic aminic groups) could have any effect in impairing SARS-CoV2 entry in the host cell. This could open to new therapeutic
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The effects of morin on bone regeneration to accelerate healing in bone defects in mice Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-09 Jun Wan; Tao Ma; Yun Jin; Shaodong Qiu
Restoring bone defects are the major challenge facing clinical trial therapy, particularly skull related problems. Morin, a naturally occurring compound, has pro-osteogenesis. This research focuses on assessing the role of morin for its pro-osteogenesis activities. We utilized in vivo and in vitro models to investigate the molecular-level mechanisms of morin’s osteoblastic biological activity. The
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Fatal food-induced anaphylaxis: Determination of tryptase and specific IgE on cadaveric blood samples. What else for a better methodological standard? Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-05 Stefano D’Errico; Alessandro Santurro; Matteo Scopetti; Paola Frati; Vittorio Fineschi
Post-mortem investigation in cases of fatal anaphylaxis is required to provide clarifications on the presence of macroscopic pathological changes, histological features, and immunohistochemical positivity suggestive of the diagnosis, on biochemical evidence of anaphylaxis and on the presence of serological data indicative of the allergen responsible for the anaphylactic reaction. We describe the case
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Risk factors of necrotizing enterocolitis in neonates with sepsis: A retrospective case-control study Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-10-05 Zheng-Li Wang; Yao An; Yu He; Xiao-Yu Hu; Lu Guo; Qiu-Yu Li; Li Liu; Lu-Quan Li
Sepsis, a severe infectious disease in the neonatal period, is considered a risk factor for necrotizing enterocolitis (NEC). To investigate the specific risk factors for NEC in septic infants, septic infants admitted to our center from January 2010 to April 2018 were included. Septic neonates with proven NEC (Bell’s stage ⩾II) were enrolled in the NEC group, and those without NEC were enrolled in the
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Human diamine oxidase is readily released from activated neutrophils ex vivo and in vivo but is rarely elevated in bacteremic patients Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-30 Thomas Boehm; Matthias Karer; Peter Matzneller; Nina Buchtele; Franz Ratzinger; Karin Petroczi; Christian Schoergenhofer; Michael Schwameis; Heinz Burgmann; Markus Zeitlinger; Bernd Jilma
During human diamine oxidase (DAO) ELISA development we noticed that in serum DAO concentrations appear to be higher when compared to plasma. Neutrophils contain DAO in the specific granules and we hypothesized that DAO is released from neutrophils during serum coagulation. If activation of neutrophils can release DAO, its concentrations might be elevated in vivo after lipopolysaccharide (LPS) administration
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LncRNA TMPO-AS1 facilitates the proliferation and metastasis of NSCLC cells by up-regulating ERBB2 via sponging miR-204-3p. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-24 Xiaobo Yu,Qiang Lin,Fabing Liu,Fu Yang,Jingyu Mao,Xi Chen
Introduction: This study aims at probing into the expression and biological function of long non-coding RNA (lncRNA) TMPO-AS1 in non-small cell lung cancer (NSCLC), and exploring its regulatory role for miR-204-3p and erb-b2 receptor tyrosine kinase 2 (ERBB2). Methods: In this study, paired NSCLC samples were collected, and the expression levels of TMPO-AS1, miR-204-3p and ERBB2 were examined by quantitative
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Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-22 Xue Jiang,Xiaopeng Li,Shuang Zheng,Guangying Du,Jinbo Ma,Liming Zhang,Hongbo Wang,Jingwei Tian
Introduction: Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360, NLG919) from the pharmacological perspective. Methods: In vitro experiments included:
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Myrcene exerts anti-asthmatic activity in neonatal rats via modulating the matrix remodeling. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-22 Yanhui Du,Jie Luan,Ren Peng Jiang,Juan Liu,Yan Ma
Myrcene (MC), an organic hydrocarbon, was found to exert anti-inflammatory, analgesic, antimutagenic and antioxidant properties. However, the protective role of MC has not been reported against neonatal asthma. Wistar rats induced with asthma were administered with MC; while asthma control and vehicle control were maintained without MC administration. At the end of the experimental period, lung histology
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Efficacy and safety of human intravenous immunoglobulin 5% (Ig VENA) in pediatric patients affected by primary immunodeficiency. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-14 Silvia Ricci,Francesca Lippi,Clementina Canessa,Chiara Guarnieri,Roberta Macchia,Chiara Azzari
Patients affected by primary immunodeficiencies are characterized for high susceptibility for severe infections. Our data demonstrate Kedrion 5% intravenous immunoglobulin G (IVIg) treatment effective and safe as replacement therapy for children and adolescents affected by primary immunodeficiency. The particularities of our study are the selection of a long period of follow-up (71 patient-years of
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Preliminary study on the anti-apoptotic mechanism of Astragaloside IV on radiation-induced brain cells. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-09 Xin Liu,Weiwei Chu,Shuying Shang,Liang Ma,Chenxin Jiang,Yanping Ding,Jianlin Wang,Shengxiang Zhang,Baoping Shao
With multiple targets and low cytotoxicity, natural medicines can be used as potential neuroprotective agents. The increase in oxidative stress levels and inflammatory responses in the brain caused by radiation affects cognitive function and neuronal structure, and ultimately leads to abnormal changes in neurogenesis, differentiation, and apoptosis. Astragaloside Ⅳ (AS-Ⅳ), one of the main active constituents
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Activation of cholinergic anti-inflammatory pathway involved in therapeutic actions of α-mangostin on lipopolysaccharide-induced acute lung injury in rats. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-09-04 Zhe Yang,Qin Yin,Opeyemi Joshua Olatunji,Yan Li,Shu Pan,Dan-Dan Wang,Jian Zuo
Introduction: Alpha-mangostin (MAN) possesses a wide variety of pharmacological effects. In this study, we investigated its effect on cholinergic anti-inflammatory pathway (CAP), and tested if CAP regulation was involved in the therapeutic action on acute lung injury (ALI). Methods: Male Sprague Dawley rats were pre-treated with MAN (40 mg/kg) for 3 days and ALI was induced with an intraperitoneal
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Reversal of age-associated oxidative stress in mice by PFT, a novel kefir product. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-31 Mamdooh Ghoneum,Shaymaa Abdulmalek,Deyu Pan
Introduction: Oxidative stress is a key contributor to aging and age-related diseases. In the present study, we examine the protective effects of PFT, a novel kefir product, against age-associated oxidative stress using aged (10-month-old) mice. Methods: Mice were treated with PFT orally at a daily dose of 2 mg/kg body weight over 6 weeks, and antioxidant status, protein oxidation, and lipid peroxidation
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Impact of IL-10 gene polymorphisms and its interaction with environment on susceptibility to systemic lupus erythematosus. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-26 Gui-Hong Wang,Ting Zuo,Zheng-Cai Zuo
This study aims to explore the impact of interleukin (IL)-10 single nucleotide polymorphisms (SNPs) and its interaction with environment on the risk of systemic lupus erythematosus (SLE). Chi-square testing method was used to investigate whether the distributions for genotype of four SNPs were differed from Hardy-Weinberg equilibrium (HWE). Logistic regression was used to test the association between
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Concordance between clinical diagnosis of pulmonary thromboembolism at hospital discharge and anatomopathological diagnosis. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-24 Benjamín Rubio-Jurado,Rocío Concepción Albores-Arguijo,Antonio Guerra-Soto,Teresita Plasencia-Ortiz,Gerónimo Tavarez-Macías,Jennifer Huerta-Hernández,Carlos Riebeling-Navarro,Arnulfo Hernán Nava-Zavala
Half of the cases of pulmonary thromboembolism (PTE) are not diagnosed because of its unspecific clinical presentation; in Mexico, autopsy data reveal a similar incidence to that of developed countries. The objective of this work was to know the concordance between the clinical diagnosis of PTE at hospital discharge and its autopsy diagnosis. The method used was a retrospective cohort study of cases
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Cell-specific expression of ENACα gene by FOXA1 in the glucocorticoid receptor pathway. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-24 Young Sun Chung,Hong Lan Jin,Kwang Won Jeong
Introduction: The glucocorticoid receptor (GR) is one of the most widely studied ligand-dependent nuclear receptors. The combination of transcriptional regulatory factors required for the expression of individual genes targeted by GR varies across cell types; however, the mechanisms underlying this cell type–specific regulation of gene expression are not yet clear. Methods: Here, we investigated genes
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A case of late-onset larynx angioedema after ranibizumab intravitreal injection: Ranibizumab-related angioedema. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-21 Maddalena De Bernardo,Cristiana Stellato,Nicola Rosa,Ilaria De Pascale,Francesco Antonio Salzano
This case report describes an unusual case of late-onset larynx angioedema after ranibizumab intravitreal injection. A 72-year-old female patient presented to our clinic for decreased vision; right eye (RE) fundoscopy and optical coherence tomography (OCT) revealed mild chorioretinal atrophy and choroidal neovascularization with subretinal fluid. A ranibizumab injection was planned in the RE, with
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Differences in clinical characteristics of early- and late-onset neonatal sepsis caused by Klebsiella pneumoniae. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-20 Ting You,Han Zhang,Lu Guo,Ke-Ran Ling,Xiao-Yu Hu,Lu-Quan Li
To identify differences in the clinical characteristics of early- and late-onset sepsis (EOS and LOS) caused by Klebsiella pneumoniae (K. pneumoniae) and to describe the risk factors for multidrug-resistant K. pneumoniae (MDR-KP) infection. Infants with K. pneumoniae-induced sepsis who were admitted to a children’s Hospital between Jan 2000 and Dec 2019 were included. All infants were divided into
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Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-20 Yirong Chen,Renye Que,Liubing Lin,Yanting Shen,Jinkai Liu,Yong Li
NLRP3 inflammasome activation results in severe liver inflammation and injury. Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study aimed to determine the protective effects of SSd on carbon tetrachloride (CCl4)-induced acute liver injury in mice, and whether oxidative stress and NLRP3 inflammasome activation participate in the process. The CCl4 mice model and controls
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Real-life effects of benralizumab on allergic chronic rhinosinusitis and nasal polyposis associated with severe asthma. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-20 Nicola Lombardo,Corrado Pelaia,Marco Ciriolo,Marcello Della Corte,Giovanna Piazzetta,Nadia Lobello,Pasquale Viola,Girolamo Pelaia
The aim of this study has been to evaluate the efficacy of the IL-5 receptor blocker benralizumab on chronic rhinosinusitis with nasal polyposis (CRSwNP), associated with severe eosinophilic allergic asthma. Ten patients with severe eosinophilic allergic asthma and CRSwNP were enrolled. Sino-nasal outcome test (SNOT-22), numerical rating scale (NRS), endoscopic nasal polyp score, Lund Mackey CT (computed
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Could nasal irrigation and oral rinse reduce the risk for COVID-19 infection? Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-08-15 Manuele Casale,Vittorio Rinaldi,Lorenzo Sabatino,Antonio Moffa,Massimo Ciccozzi
Public health measures are essential to protect against COronaVIrus Disease 2019 (COVID-19). The nose and the mouth represent entry portals for the COVID 19. Saline Nasal Irrigations (SNIs) can reduce the viral load in the nasal cavities. Oral rinse with antimicrobial agents is efficacious in reducing the viral load in oral fluids. We advocate the inclusion of SNIs and ethanol oral rinses as additional
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Herpes simplex virus type I-infected disorders alter the balance between Treg and Th17 cells in recurrent herpes labialis patients. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-31 Xian-Xian Mei,Shan-Shan Lei,Li Xu,Shan Wu,Huan-Peng Gu,Yu Du,Ting Zhao,Guan-Qun Xie,Yong-Sheng Fan,Xiao-Ping Pan,Jie Bao
Recurrent herpes labialis (RHL) is a common skin disease that is often caused by herpes simplex virus type I (HSV-1), but its immunology and pathogenesis remain unclear. The balance of Th17/Treg cells is crucial for maintaining immune homeostasis. This study aimed to investigate whether the balance of Th17/Treg cells and related cytokines may be a determinant occurrence in patients with RHL. This is
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The first study in pediatric: Population pharmacokinetics of sirolimus and its application in Chinese children with immune cytopenia. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-28 Xiaoling Cheng,Yiming Zhao,Hao Gu,Libo Zhao,Yannan Zang,Xiaoling Wang,Runhui Wu
The narrow therapeutic index and large inter-individual variability in sirolimus pharmacokinetics (PK) make therapeutic drug monitoring (TDM) necessary. Factors responsible for PK variability are not well understood, and published PK studies do not include pediatric patients with immune cytopenia. The objective of this study was to characterize the PK of sirolimus in pediatric patients with immune
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Effects of betulinic acid on synovial inflammation in rats with collagen-induced arthritis. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-27 Kun-Liu,Jian-Ying Wang,Lei Zhang,Ying-Yi Pan,Xiao-Yun Chen,Ying Yuan
Betulinic acid (BA) inhibits the migration, invasion, and cytoskeletal reorganization of fibroblast-like synoviocytes (RA-FLS) in patients with rheumatoid arthritis. Here, to further explore the mechanism of action of BA in collagen-induced arthritis (CIA) rats, we investigated the pharmacodynamic effects of BA on synovial inflammation in a rat model of type II CIA. After inducing hind paw swelling
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Network pharmacology-based identification of the antitumor effects of taraxasterol in gastric cancer. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-23 Wei Chen,Jingwei Li,Chen Li,Hui-Ning Fan,Jing Zhang,Jin-Shui Zhu
Taraxasterol (TAX), a pentacyclic triterpene, has been reported to exhibit potent antitumor activity. However, the effects and molecular mechanisms of TAX in gastric cancer (GC) remain undocumented. A network pharmacology approach was applied to identify the collective targets of TAX and GC. Nude mice were subcutaneously injected with MKN-28 cells to establish GC subcutaneous xenograft model, which
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Does inappropriate initial antibiotic therapy affect in-hospital mortality of patients in the emergency department with Escherichia coli and Klebsiella pneumoniae bloodstream infections? Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-23 Fu-Cheng Chen,Yu-Ni Ho,Hsien-Hung Cheng,Chien-Hung Wu,Meng-Wei Change,Chih-Min Su
Extended-spectrum β-lactamase (ESBL)-positive bloodstream infection (BSI) is on the rise worldwide. The purpose of this study is to evaluate the impact of inappropriate initial antibiotic therapy (IIAT) on in-hospital mortality of patients in the emergency department (ED) with Escherichia coli and Klebsiella pneumoniae BSIs. This retrospective single-center cohort study included all adult patients
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Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab: Where do we stand today? Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-20 Jakub Novosad,Irena Krčmová
Bronchial asthma is a heterogeneous disease whose definition and treatment are based on evidence of variable airway obstruction and airway inflammation. Despite the enormous increase in the amount of information on the pathogenesis of this disease, diagnosis is still an unresolved problem, as we still lack sensitive and specific biomarkers. On the other hand, at the turn of the 20th and 21st century
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A rare case of eosinophilic cholangiopathy. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-20 Wenya Li,Feizhao Jiang,Xiaoxiao Li,Hong Li,Zhihai Zheng
Eosinophilic cholangiopathy is termed as a rare, benign, and self-limiting disease. Moreover, the interference of malignant tumor to diagnosis and the changing process of disease make the accurate treatment proposal challenging. A significant number of patients require surgery for the definitive diagnosis and resolution of symptoms. We put forward a case of eosinophilic cholangiopathy infiltrating
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Knockdown of Ezrin inhibited migration and invasion of cervical cancer cells in vitro. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-17 Meili Xi,Wenbin Tang
Cervical cancer is the fourth most common malignancy in women. The aim of this study was to investigate the functions of Ezrin in cervical cancer cells. Two cervical cancer cell lines, SiHa and CaSki, were cultured in vitro. Following the knockdown of Ezrin using siRNA, real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis were applied to analyze Ezrin expression
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Drug-related talaromycosis: A case report. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-17 Yongsheng Lu,Quan Shi,Jing Yu
Talaromycosis is a rare deep fungal infection caused by Talaromyces marneffei. Currently, methamphetamine has become the second-largest drug abuse category in the world after cannabis and has become a serious public health problem. Methamphetamine can inhibit human immune system and increase the probability of pathogenic microorganism infection. On 8 October 2016, a 20-year-old man with a fever history
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Protective effect of resveratrol on estrogen deficiency-induced osteoporosis though attenuating NADPH oxidase 4/nuclear factor kappa B pathway by increasing miR-92b-3p expression. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-17 Ye Zhang,Ming-Wei Liu,Yun He,Ning Deng,Yan Chen,Jiecong Huang,Wei Xie
Introduction: Resveratrol (RES) exhibits estrogen-like effects and has potential applications to treatment of osteoporosis caused by estrogen deficiency; however, the specific mechanism of action of RES remains unclear. Here, we examined the therapeutic effects of RES on ovariectomized (OVX) rats with osteoporosis and determined the underlying mechanism. Methods: We established an OVX rat model to
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Primary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: Challenge in diagnostic practice. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-15 Qian Liu,Xian Chen,Gandi Li,Yunxia Ye,Weiping Liu,Sha Zhao,Wenyan Zhang
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK + ALCL) is most frequent in youth and possesses a broad morphologic spectrum. However, involvement in central nervous system (CNS) is definitely rare. The case we presented was a 12-year-old Chinese male who presented with headache and emesis for a couple of days. The neoplastic component was smaller cells resembling starry-sky
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Effects of emodin on intestinal mucosal barrier by the upregulation of miR-218a-5p expression in rats with acute necrotizing pancreatitis. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-15 Yang Tan,Wei Zhang,Hai-Ying Wu,Jing Xia,Huang-Bo Zhang,Ming-Wei Liu,Chuan-Yun Qian
Emodin is an effective component in rhubarb to cure intestinal dysfunction, but the specific mechanism remains unknown. This study aimed to evaluate the protective effects of emodin on intestinal dysfunction caused by acute severe pancreatitis and reveal the functional mechanism of emodin in the treatment of this condition. An acute severe pancreatitis model was prepared using taurocholate. In the
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Don't forget ototoxicity during the SARS-CoV-2 (Covid-19) pandemic! Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-10 Andrea Ciorba,Virginia Corazzi,Piotr Henryk Skarżyński,Magdalena B Skarżyńska,Chiara Bianchini,Stefano Pelucchi,Stavros Hatzopoulos
Aim of this communication is to remind clinical professionals to be aware of ototoxic side effects of several specific drugs proposed for the treatment of the new virus SARS-CoV-2 (Covid-19). In particular, chloroquine and hydroxychloroquine, azithromycin, as well as antiviral drugs such as remdesivir, favipiravir and lopinavir can all present potential ototoxic side effects. The data in the literature
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Typhae pollen polysaccharides protect hypoxia-induced PC12 cell injury via regulation of miR-34a/SIRT1. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-07 Shichun Wang,Qianqian Tang,Fuchao Ge,Qing Guo
This current research was performed to investigate the role of typhae pollen polysaccharides (TPP) in hypoxia-treated PC12 cell which was an in vitro cell model of cerebral ischemia. Hypoxia-treated cells were treated with TPP for 12 h. Cell viability and apoptosis were detected by 3-(4,5-dimethylthiazol-2-yl)-2 5-diphenyl-2H-tetrazolium bromide (MTT) assay and flow cytometry, respectively. Cell apoptotic
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Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-07 Laura Maria Mongioì,Angela Alamo,Aldo E Calogero,Michele Compagnone,Filippo Giacone,Rossella Cannarella,Sandro La Vignera,Rosita Angela Condorelli
Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm analysis was conducted according to the World Health Organization (WHO) 2010 criteria
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A previously treated severe haemophilia A patient developed high-titre inhibitor after vaccinations. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-07-06 Zekun Li,Zhenping Chen,Xiaoling Cheng,Xinyi Wu,Gang Li,Yingzi Zhen,Man-Chiu Poon,Runhui Wu
The factor VIII (FVIII)-neutralizing antibody (inhibitor) seen in 25%–30% of patients with severe haemophilia A (SHA). Vaccination is a non-genetic risk factor of inhibitor development as ‘danger signal’ which may provide a pro-inflammatory microenvironment to increase FVIII immunogenicity. We reported a previously treated SHA patient postponed the first vaccination to 15-month age received diphth
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Upregulation of the miRNA-155, miRNA-210, and miRNA-20b in psoriasis patients and their relation to IL-17. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-06-30 Mohamed El-Komy,Iman Amin,Marwa Safwat El-Hawary,Dina Saadi,Olfat Shaker
Psoriasis is an immune-mediated disease, with genetic background and triggering environmental factors; however, several gaps are still present in understanding the intertwined relationship between these elements. Epigenetic mechanisms, including microRNAs (miRNAs), play an important role in the pathogenesis of psoriasis. The relationship between interleukin (IL)-17, a key cytokine in psoriasis, and
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External validation of the sepsis severity score. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-06-30 Marek Wełna,Barbara Adamik,Waldemar Goździk,Andrzej Kübler
Introduction: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality rates are high, exceeding 50% in patients with septic shock. The sepsis severity score (SSS) was developed to determine the severity of sepsis and as a prognostic model. The aim of this study was to externally validate the SSS model. Methods: Calibration and discrimination
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Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-06-22 Chieh-Shan Wu,Shih-Chao Lin,Shiming Li,Yu-Chih Chiang,Nicole Bracci,Caitlin W Lehman,Kuo-Tung Tang,Chi-Chien Lin
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient’s quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-derived phenolic compound, phloretin, to treat allergic contact dermatitis (ACD) on
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Renal cell carcinoma associated with idiopathic thrombocytopenic purpura. Int. J. Immunopathol. Pharmacol. (IF 2.209) Pub Date : 2020-06-22 Xi Xie,Ning Wang,Jingjing Xiang,Huadong He,Xuliang Wang,Yuyong Wang
We presented the clinical data of one patient with renal cell carcinoma associated with idiopathic thrombocytopenic purpura in this case report. We reported a 56-year-old man who presented with petechiae and ecchymoses. Laboratory studies showed the platelet count of 2 × 109/L and an abdominal computed tomography (CT) scan revealed tumors in the right renal. There were purpura on the legs and cough