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An Aloe-Based Composition Constituting Polysaccharides and Polyphenols Protected Mice against D-Galactose-Induced Immunosenescence J. Immunol. Res. (IF 4.1) Pub Date : 2024-3-14 Mesfin Yimam, Teresa Horm, Alexandria O’Neal, Ping Jiao, Mei Hong, Qi Jia
A decline in immune response, exhibited in the form of immunosenescence and inflammaging, is an age-associated disturbance of the immune system known to predispose the elderly to a greater susceptibility to infection and poor vaccine response. Polysaccharides and polyphenols from botanicals are known for their immune modulation effects. Here we evaluated a standardized mushroom-based composition, UP360
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The Disease Burden of Hereditary Angioedema: Insights from a Survey in French-Canadians from Quebec J. Immunol. Res. (IF 4.1) Pub Date : 2024-3-7 Jean-Nicolas Boursiquot, Hugo Chapdelaine, Charles St-Pierre, Jacques Hébert
Background. Limited data are available on the clinical profile and disease burden of hereditary angioedema (HAE) in Canadians. Objective. This study aimed to assess HAE disease characteristics and the burden of disease in Canadians with HAE types I, II, and normal levels of C1 inhibitor (nC1-INH). Materials and Methods. A 46-item patient survey evaluating clinical characteristics and burden of disease
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Clinical and Genetic Spectrum of Nine Cases of NLRP3-Associated Autoinflammatory Disease (NLRP3-AID) and Identification of One Novel NLRP3 Mutation by Genetic Variation Analyses J. Immunol. Res. (IF 4.1) Pub Date : 2024-3-6 Yaoyao Shangguan, Xingru Ding, Le Ma, Yi-Xin Cai, Shulei Xiang, Xiu-Feng Huang, Yunyan Shen, Hai-Guo Yu, Wenjie Zheng
Purpose. NLRP3-associated autoinflammatory disease (NLRP3-AID) is characterized by gain-of-function variants in the NLRP3 gene. Since there are little literature focusing on pediatric NLRP3-AID in China, we aimed to elucidate the phenotypic and genotypic profiles of Chinese patients with NLRP3-AID. Methods. Patients with NLRP3-AID at three rheumatology centers in China were genotyped through whole
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The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2–M1 Macrophage Reprogramming J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-29 Vera S. Ruzanova, Svetlana S. Kirikovich, Evgeniy V. Levites, Anastasia S. Proskurina, Evgeniya V. Dolgova, Genrikh S. Ritter, Yaroslav R. Efremov, Tatyana D. Dubatolova, Alexander V. Sysoev, Danil I. Koleno, Alexandr A. Ostanin, Elena R. Chernykh, Sergey S. Bogachev
Macrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction
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Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson’s Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-29 Hua Xue, Qian Luo, Jiajia Chen, Wenhui Fan
Background. Observational studies have suggested an association between inflammatory cytokines and Parkinson’s disease (PD). This Mendelian randomization (MR) was conducted to further assess the causal correlations between inflammatory cytokines and PD. Methods. Genetic instruments associated with inflammatory cytokines were extracted from a large summary genome-wide association studies (GWAS) involving
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-27 Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka
Multiple myeloma (MM) is an intractable hematological malignancy caused by abnormalities in plasma cells. Combination therapy using antibodies and natural killer (NK) effectors, which are innate immune cells with safe and potent antitumor activity, is a promising approach for cancer immunotherapy and can enhance antitumor effects. Elotuzumab (Elo) is an immune-stimulatory antibody that targets the
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Inhibition of Oxidative Stress-Induced Ferroptosis Can Alleviate Rheumatoid Arthritis in Human J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-26 Yang Liu, Jiang Liang, Zongge Sha, Changfu Yang
Rheumatoid arthritis (RA) is a chronic autoimmunity illness, mainly featured with synovitis of the joint. The specificity of ferroptosis is disparate in different diseases, and the mechanism of ferroptosis in RA has some uncertainty yet. Therefore, the mechanism of ferroptosis was deeply observed in RA patients and animal models. In this paper, plasma of RA patients, the tumor necrosis factor-alpha-induced
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Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-13 Masoud Foroutan, Aida Vafae Eslahi, Shahrzad Soltani, Naser Kamyari, Ehsan Moradi-Joo, Jean-Francois Magnaval, Milad Badri
Toxocariasis is one of the most common zoonotic diseases distributed worldwide. This study aimed to estimate the seroprevalence of anti-Toxocara immunoglobulin G (IgG) antibodies and the associated risk factors among general populations living in urban and rural areas of Abadan and Khorramshahr cities in Khuzestan Province, Southwest Iran. This cross-sectional study was conducted between March and
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KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-13 Shanshan Cong, Yao Fu, Xibo Zhao, Qiuyan Guo, Tian Liang, Di Wu, Jing Wang, Guangmei Zhang
Background. Ovarian cancer (OV) is characteristic of high incidence rate and fatality rate in the malignant tumors of female reproductive system. Researches on pathogenesis and therapeutic targets for OV need to be continued. This study mainly analyzed the immune-related pathogenesis and discovered the key immunotherapy targets for OV. Methods. WGCNA was used for excavating hub gene modules and hub
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Disturbances in the IgG Antibody Profile in HIV-Exposed Uninfected Infants Associated with Maternal Factors J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-12 Rodrigo T. Camacho-Pacheco, Jessica Hernández-Pineda, Yesenia Brito-Pérez, Noemi Plazola-Camacho, Irma A. Coronado-Zarco, Gabriela Arreola-Ramírez, Mextli Y. Bermejo-Haro, M. Angel Najera-Hernández, Gabriela González-Pérez, Alma Herrera-Salazar, Andrea Olmos-Ortiz, Diana Soriano-Becerril, Claudia Sandoval-Montes, Ricardo Figueroa-Damian, Sandra Rodríguez-Martínez, Ismael Mancilla-Herrera
Over the last 20 years, the incidence of vertical HIV transmission has decreased from 25%–42% to less than 1%. Although there are no signs of infection, the health of HIV-exposed uninfected (HEU) infants is notoriously affected during the first months of life, with opportunistic infections being the most common disease. Some studies have reported effects on the vertical transfer of antibodies, but
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Upper Airway Epithelial Tissue Transcriptome Analysis Reveals Immune Signatures Associated with COVID-19 Severity in Ghanaians J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-12 John Demby Sandi, Joshua I. Levy, Kesego Tapela, Mark Zeller, Joshua Afari Yeboah, Daniel Frimpong Saka, Donald S. Grant, Gordon A. Awandare, Peter K. Quashie, Kristian G. Andersen, Lily Paemka
The immunological signatures driving the severity of coronavirus disease 19 (COVID-19) in Ghanaians remain poorly understood. We performed bulk transcriptome sequencing of nasopharyngeal samples from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected Ghanaians with mild and severe COVID-19, as well as healthy controls to characterize immune signatures at the primary SARS-CoV-2 infection
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RND3 Potentiates Proinflammatory Activation through NOTCH Signaling in Activated Macrophages J. Immunol. Res. (IF 4.1) Pub Date : 2024-2-2 María José Romero de Ávila, Susana López-López, Aarón García-Blázquez, Almudena Ruiz-García, María Julia González-Gómez, María Luisa Nueda, Victoriano Baladrón, Ignacio Pérez-Roger, Enric Poch, Begoña Ballester-Lurbe, José Javier García-Ramírez, Eva M. Monsalve, María José M. Díaz-Guerra
Macrophage activation is a complex process with multiple control elements that ensures an adequate response to the aggressor pathogens and, on the other hand, avoids an excess of inflammatory activity that could cause tissue damage. In this study, we have identified RND3, a small GTP-binding protein, as a new element in the complex signaling process that leads to macrophage activation. We show that
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Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-31 Yuehong Chen, Yali Ye, Huan Liu, Zhongling Luo, Qianwei Li, Qibing Xie
This study systematically analyzes the association between interleukin-18 (IL-18) gene polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid MEDLINE, Ovid Excerpta Medica Database, and Cochrane Library were searched to identify meta-analyses that included case–control studies reporting IL-18 gene polymorphisms and RA susceptibility. Data were reanalyzed using Review
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PM2.5 Causes Increased Bacterial Invasion by Affecting HBD1 Expression in the Lung J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-27 Tianqi Zheng, Yajun Wang, Zheng Zhou, Shuyang Chen, Jinjun Jiang, Shujing Chen
Our research addresses the critical environmental issue of a fine particulate matter (PM2.5), focusing on its association with the increased infection risks. We explored the influence of PM2.5 on human beta-defensin 1 (HBD1), an essential peptide in mucosal immunity found in the airway epithelium. Using C57BL/6J mice and human bronchial epithelial cells (HBE), we examined the effects of PM2.5 exposure
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Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-27 Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi
Renal cell carcinoma (RCC) accounts for the majority of cancer-related deaths worldwide. Overexpression of CD70 has been linked to advanced stages of RCC. Therefore, this study aims to develop a multiepitope vaccine targeting the overexpressed CD70 using immunoinformatics techniques. In this investigation, in silico multiepitope vaccines were constructed by linking specific CD70 protein epitopes for
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Challenges in Emerging Vaccines and Future Promising Candidates against SARS-CoV-2 Variants J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-25 Tanmay Ghildiyal, Nishant Rai, Janhvi Mishra Rawat, Maargavi Singh, Jigisha Anand, Gaurav Pant, Gaurav Kumar, Amrullah Shidiki
Since the COVID-19 outbreak, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus has evolved into variants with varied infectivity. Vaccines developed against COVID-19 infection have boosted immunity, but there is still uncertainty on how long the immunity from natural infection or vaccination will last. The present study attempts to outline the present level of information about
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Identification and Verification of Hub Mitochondrial Dysfunction Genes in Osteoarthritis Based on Bioinformatics Analysis J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-23 Hui Niu, Xingxing Deng, Qian Zhang, Yijun Zhao, Jinfeng Wen, Wenyu Li, Huan Liu, Xiong Guo, Cuiyan Wu
Objective. Age-related mitochondrial dysfunction and associated oxidative stress may contribute to the development of osteoarthritis. The aim of this study was to identify hub genes associated with mitochondrial dysfunction in osteoarthritis (OA) patients, helping predict the risk of OA, and revealing the mechanism of OA progression. Methods. OA expression data and mitochondrial dysfunction genes were
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Exosomes Derived from Schistosoma japonicum Cystatin-Treated Macrophages Attenuated CLP-Induced Sepsis in Mice J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-23 Feifei Huang, Yayun Qian, Huihui Li, Liang Chu, Chen Wan, Qili Shen, Qianqian Li, Xiuxiu Li, Xinyue Wu, Bin Zhan, Rui Zhou, Xiaodi Yang
Sepsis is a disease caused by multiple microbial infections resulting in multiple organ failure. Schistosoma japonicum secreted cystatin (Sj-Cys) is a strong immunomodulator that stimulates M2 macrophages and alleviates inflammatory damage caused by sepsis. To determine whether the therapeutic effect of Sj-Cys on sepsis can be conveyed by the exosomes released by Sj-Cys-stimulated macrophages, RAW264
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Alleviation of Rheumatoid Arthritis by Inducing IDO Expression with Trichinella spiralis Recombinant Protein 43 J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-17 Xiao Ma, Dongming Liu, Wenhao Yu, Caixia Han
Rheumatoid arthritis (RA) represents the autoimmune disorder that shows aggressive arthritis as the main symptom. It is difficult to treat and can lead to joint deformation and function loss. At present, Trichinella spiralis (T. spiralis) antigen has attracted much attention because it plays a role in host immune regulatory mechanisms. Therefore, we selected T. spiralis recombinant protein 43 (Tsp43)
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Blocking Superantigen-Mediated Diseases: Challenges and Future Trends J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-17 Pengbo Wang, Zina Fredj, Hongyong Zhang, Guoguang Rong, Sumin Bian, Mohamad Sawan
Superantigens are virulence factors secreted by microorganisms that can cause various immune diseases, such as overactivating the immune system, resulting in cytokine storms, rheumatoid arthritis, and multiple sclerosis. Some studies have demonstrated that superantigens do not require intracellular processing and instated bind as intact proteins to the antigen-binding groove of major histocompatibility
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Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-16 Xueshan Huang, Min Yang, Ma Ye, Jun Qiu, Yanping Chen
Objective. To explore the impact of non-pharmacological interventions on inhaled allergen sensitization in children during the COVID-19 pandemic. Methods. The positive rate of inhaled allergens, allergens sIgE grade, and multiple sensitization rates before and during the pandemic were analyzed retrospectively in this study. Logistic regression analysis was used to compare the positive rate of allergens
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Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-13 Yingxiang Yang, Chengyue Jin, Anthony Yeo, Bo Jin
Toll-like receptors (TLRs) belong to a germline-encoded protein family. These are pattern recognition receptors. They sense pathogen-associated molecular patterns (PAMPs). When this occurs, activation of the NF-ĸB pathway follows. This triggers the innate immune response of the host. The consequent inflammatory cytokine response usually contributes to the elimination of the pathogen. Activation of
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CD169 Expression in Lymph Nodes is Associated with Increased Infiltration of CD8+ T Cells in Tumors: A Systematic Review and Meta-Analysis J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-12 Yong Wang, Xiao-Ting Wu, Jing Chen
The density of CD169+ macrophages has been reported to positively correlate with the number of CD8+ T cells, although this remains controversial. To better understand this topic, we conducted a meta-analysis. We searched the PubMed, Medline, and Web of Science databases for studies that were published before May 2022 and performed a meta-analysis of the incidence of low and high CD169 expression in
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The Plasticity of Immune Cell Response Complicates Dissecting the Underlying Pathology of Multiple Sclerosis J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-4 Sujan Kumar Sarkar, Annie M. L. Willson, Margaret A. Jordan
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease characterized by the destruction of the myelin sheath of the neuronal axon in the central nervous system. Many risk factors, including environmental, epigenetic, genetic, and lifestyle factors, are responsible for the development of MS. It has long been thought that only adaptive immune cells, especially autoreactive T cells, are responsible
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Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies J. Immunol. Res. (IF 4.1) Pub Date : 2024-1-3 Sofia Smargianaki, Evelina Elmér, Sandra Lilliebladh, Sophie Ohlsson, Åsa Pettersson, Thomas Hellmark, Åsa CM Johansson
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases with inflammation affecting small blood vessels and includes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). In this study, we investigated granulocyte and monocyte subsets in a large cohort of AAV patients with emphasis on disease activity and tendency to relapse. A cohort
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A Novel Pyroptosis-Based Prognostic Model Correlated with the Parainflammatory Immune Microenvironment of Pancreatic Cancer J. Immunol. Res. (IF 4.1) Pub Date : 2023-12-21 Kong-kong Wei, Zhi-xing Du, Jun-ge Deng, Jin-wei Yang, Hao Chen
Background. Pyroptosis has a dual function in malignant tumor progression and management. The action of pyroptosis-related genes (PRGs) in pancreatic cancer (PC), however, remains uncertain. Methods. Differential expression analyses of 57 PRGs were conducted in the TCGA TARGET GTEx dataset. The candidate genes were determined using LASSO Cox regression and random forest analyses. A risk model was developed
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DJ-1: A Potential Biomarker Related to Prognosis, Chemoresistance, and Expression of Microenvironmental Chemokine in HR-Positive Breast Cancer J. Immunol. Res. (IF 4.1) Pub Date : 2023-12-13 Yinghong Xie, Yuancheng Li, Mengzhu Yang
DJ-1 is significantly elevated in various malignancies. However, the clinical significance of DJ-1 in hormone receptor (HR)-positive (HR+) breast cancer remains unclear. We evaluated DJ-1 expression in different databases and validated in vitro assay by RT-PCR and western blot among HR+ breast cancer. The correlations between DJ-1 level and tumor-immune were calculated. Mutational landscape, enriched
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The Expression of Semaphorin3E in Vagal Ganglion and Lung Tissue Is Related to Airway Hyperresponsiveness in Murine Asthma Model J. Immunol. Res. (IF 4.1) Pub Date : 2023-12-11 Liyan Chen, Xiaohui Yuan, Yaowei He, Zichuan Fan, Ya Guan, Qiuying Li, Yaying Chen, Lianglan Bao, Yidan Huang, Kefang Lai
Objective. Semaphorin3E (Sema3E) mediates reorganization of the actin cytoskeleton, and plays an important role in ensuring the specificity of synapse formation and angiogenesis. However, the role of Sema3E in allergic asthma (AS) and eosinophilic bronchitis (EB) is still elusive. This study aimed to investigate the relationship between Sema3E in vagal ganglion and lung tissue, airway reactivity, and
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Development of an Anoikis-Related Gene Signature for Lung Squamous Cell Carcinomato Predict Prognosis, Immune Landscape, and Immunotherapy Response J. Immunol. Res. (IF 4.1) Pub Date : 2023-12-9 Jian Liu, Hui Zheng, Li Wei
Background. Anoikis, a form of programed cell death, plays a pivotal role in the invasion and metastasis of various tumors, including lung squamous cell carcinoma (LUSC). This study aims to construct a prognostic model for LUSC, leveraging anoikis-related genes (ARGs). Methods. A total of 357 ARGs were extracted from the GeneCards database and Harmonizome portals. Subsequently, ARGs influencing LUSC
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Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases J. Immunol. Res. (IF 4.1) Pub Date : 2023-12-8 Wai Chung Wu, Carol Shiu, Tak Keung Tong, Shui On Leung, Chin Wai Hui
Natural killer (NK) cell is an essential cytotoxic lymphocyte in our innate immunity. Activation of NK cells is of paramount importance in defending against pathogens, suppressing autoantibody production and regulating other immune cells. Common gamma chain (γc) cytokines, including IL-2, IL-15, and IL-21, are defined as essential regulators for NK cell homeostasis and development. However, it is inconclusive
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Risk Prediction Models for Invasive Mechanical Ventilation in Patients with Autoimmune Encephalitis: A Retrospective Cohort Study J. Immunol. Res. (IF 4.1) Pub Date : 2023-12-5 Shiyang Xie, Meilin Chen, Luying Qiu, Long Li, Shumin Deng, Fang Liu, Hefei Fu, Yanzhe Wang
Background and Objectives. Timely identification of developing severe respiratory failure in patients with autoimmune encephalitis (AE) is crucial to ensure prompt treatment with invasive mechanical ventilation (IMV), which can potentially improve the outcome. We aimed to develop a nomogram for requiring IMV based on easily available clinical characteristics. Methods. A multivariate predictive nomogram
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Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-25 Jifeng Tang, Jinfang Xia, Huiming Sheng, Jinpiao Lin
Background. The aim of the study was to investigate the landscape of B-cell-related gene expression profiling in rheumatoid arthritis (RA) synovium and explore the biological and clinical significance of these genes in RA. Methods. Expression profiling of synovial biopsies from subjects with 152 RA patients, 22 osteoarthritis (OA) patients, and 28 healthy controls was downloaded from the Gene Expression
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EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-24 Stephan Dreschers, Christopher Platen, Louise Oppermann, Caitlin Doughty, Andreas Ludwig, Aaron Babendreyer, Thorsten W. Orlikowsky
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to regulate the phagocytosis-induced cell death of monocytes in peripheral blood. AREG-dependent apoptotic signaling engages factors of the intrinsic and extrinsic apoptotic pathway, such as BCL-2, BCL-XL, and death ligand/receptor CD95/CD95L. Here, we tested the hypothesis that AREG influences costimulatory
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Targeting Neutrophil Extracellular Traps: A Novel Antitumor Strategy J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-9 Hao Zuo, Mengjie Yang, Qian Ji, Shengqiao Fu, Xi Pu, Xu Zhang, Xu Wang
The clinical efficacy of surgery, radiotherapy, and chemotherapy for cancer is usually limited by the deterioration of tumor microenvironment (TME). Neutrophil extracellular traps (NETs) are decondensed chromatin extruded by neutrophils and are widely distributed among various cancers, such as pancreatic cancer, breast cancer, and hepatocellular carcinoma. In the TME, NETs interact with stromal components
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Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4) J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-7 Zhaoxing Dong, Ting Li, Cenli Wang, Yong Zhou, Zhongkai Tong, Xuekui Du
Pulmonary fibrosis (PF) can lead to chronic inflammation, the destruction of alveoli and irreversible lung damage. Sestrin2 is a highly protective stress-inducible protein that is involved in the cell response to various stress factors and the regulation of homeostasis and has a certain protective effect against PF. In this study, TGF-β1 was used to establish a PF cell model. Bleomycin was used to
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GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-6 Jing Ning, Jianqiao Ding, Shu Wang, Youhong Jiang, Daqing Wang, Shenyi Jiang
Lung squamous cell carcinoma (LUSC) is associated with poor clinical prognosis and lacks available targeted agents. GPC3 is upregulated in LUSC. Our study aimed to explore the roles of GPC3 in LUSC and the antitumor effects of HLA-A2-restricted GPC3 antigenic peptide-sensitized dendritic cell (DC)-induced cytotoxic T lymphocytes (CTLs) on LUSC. LUSC cells with GPC3 knockdown and overexpression were
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Common Pollen Modulate Immune Responses against Viral-Like Challenges in Airway Coculture Model J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-6 Tarleena Tossavainen, Maria-Viola Martikainen, Hanna Loukola, Marjut Roponen
Recent research indicates that exposure to pollen increases the risk and severity of respiratory infections, while studies also suggest that it may possess a protective function. Our aim was to investigate how exposure to common pollen modifies airway cells’ responses to viral- or bacterial-like challenges and vice versa. Cocultured A549 and THP-1 cells were exposed to three doses of four different
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Understanding How Minerals Contribute to Optimal Immune Function J. Immunol. Res. (IF 4.1) Pub Date : 2023-11-1 Alina Stefanache, Ionut-Iulian Lungu, Ioan-Adrian Butnariu, Gabriela Calin, Cristian Gutu, Constantin Marcu, Carmen Grierosu, Elena Roxana Bogdan Goroftei, Letitia-Doina Duceac, Marius Gabriel Dabija, Florina Popa, Daniela Damir
Sufficient mineral supply is vital not only for the innate immune system but also for the components of the adaptive immune defense, which encompass defense mechanisms against pathogens and the delicate balance of pro- and anti-inflammatory regulation in the long term. Generally, a well-balanced diet is capable of providing the necessary minerals to support the immune system. Nevertheless, specific
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Bone Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Lipopolysaccharide-Induced Lung Injury Via the miR-21-5p/PCSK6 Pathway J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-28 Bo Cai, Weidong Song, Song Chen, Jie Sun, Rui Zhou, Zhen Han, Jian Wan
Acute lung injury (ALI) is a life-threatening disease that currently lacks a cure. Although stem cell-derived small extracellular vesicles (sEVs) have shown promising effects in the treatment of ALI, their underlying mechanisms and responsible components have yet to be identified. Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a gene involved in inflammation and a potential target of miR-21-5p
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Circulating miR-320b Contributes to CD4+ T-Cell Proliferation in Systemic Lupus Erythematosus via MAP3K1 J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-26 Zutong Li, Rou Wang, Dandan Wang, Shujie Zhang, Hua Song, Shuai Ding, Yantong Zhu, Xin Wen, Hui Li, Hongwei Chen, Shanshan Liu, Lingyun Sun
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies and tissue inflammation. Mesenchymal stem cells (MSCs) have emerged as a promising candidate therapy for SLE owing to the immunomodulatory and regenerative properties. Circulating miRNAs are small, single-stranded noncoding RNAs in a variety of body fluids that regulate numerous immunologic
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Tim-3 Is Differentially Expressed during Cell Activation and Interacts with the LSP-1 Protein in Human Macrophages J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-26 Ranferi Ocaña-Guzman, Lucero A. Ramon-Luing, Luis A. Vazquez-Bolaños, Michelle Rodríguez-Alvarado, Fausi Bulhusen-Rodriguez, Alonso Torres-Hatem, Karen Gonzalez-Torres, Mariana Citlalli de Alba-Alvarado, Isabel Sada-Ovalle
T-cell Immunoglobulin and Mucin Domain 3 (TIM-3) is an immune checkpoint receptor known to regulate T-cell activation and has been targeted for immunotherapy in cancer and other diseases. However, its expression and function in other cell types, such as macrophages, are poorly understood. This study investigated TIM-3 expression in human macrophages polarized to M1 (stimulated with IFN-γ and LPS) and
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The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-20 Bente M. Houtman, Iris Walraven, Elke de Grouw, Richard W. M. van der Maazen, Leontien C. M. Kremer, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Wim J. E. Tissing, Dorine Bresters, Helena J. H. van der Pal, Andrica C. H. de Vries, Marloes Louwerens, Margriet van der Heiden-van der Loo, Sebastian J. C. Neggers, Geert O. Janssens, Nicole M. A. Blijlevens, Annechien J. A. Lambeck, Frank
Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the
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Dupilumab Efficacy in Patients with Type 2 Asthma with and without Elevated Blood Neutrophils J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-19 Eugene R. Bleecker, Reynold A. Panettieri, Njira L. Lugogo, Jonathan Corren, Nadia Daizadeh, Juby A. Jacob-Nara, Yamo Deniz, Paul J. Rowe, Angela Khodzhayev, Xavier Soler, Thomas J. Ferro, Christopher N. Hansen
Introduction. Elevated neutrophil counts in blood, sputum, or lung have been associated with poor clinical outcomes and more severe disease in patients with type 2 asthma. In the phase 3 LIBERTY ASTHMA QUEST (NCT02414854), add-on dupilumab 200 and 300 mg every 2 weeks compared with matched placebo significantly reduced severe asthma exacerbations and improved forced expiratory volume in 1 s (FEV1)
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Association between Butter, Margarine, and Olive Oil Intake and Asthma Symptoms among School Children: Result from a Large-Scale Cross-Sectional Study J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-18 Arezoo Sadat Emrani, Bahareh Sasanfar, Zahra Nafei, Nasrin Behniafard, Amin Salehi-Abargouei
Background. There are conflicting results about the association between dietary fat intake and asthma symptoms. Since few studies in the Middle East have been explored the relation between dietary fat consumption and risk of asthma, the present study was conducted to investigate the association between the consumption of butter, margarine, and olive oil and asthma risk in school children living in
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Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-18 Kazuko Fujita, Taku Kuwabara, Bing Wang, Kaoru Tanaka, Kei Ito, Yuri Akishima-Fukasawa, Tetuo Mikami, Yoshikiyo Akasaka, Toshiharu Ishii
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can induce systemic inflammation. Ultraviolet-A and X-ray irradiation have been reported to have therapeutic effects in patients with SLE. We previously demonstrated that CD180-negative cells, these are radiosensitive, contribute to the development of SLE-like morbidity in NZBWF1
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Broadly Reactive SARS-CoV-2-Specific T-Cell Response and Participation of Memory B and T Cells in Patients with Omicron COVID-19 Infection J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-17 Pragya D. Yadav, Rima R. Sahay, Sukeshani Salwe, Diptee Trimbake, Prasad Babar, Gajanan N. Sapkal, Gururaj R. Deshpande, Kiran Bhise, Anita M. Shete, Priya Abraham, Anuradha S. Tripathy
January 2022 onward, India witnessed a sudden increase in Omicron COVID-19 infections, having a mild course that prompted us to identify the key host factors/immune molecules modulating disease course/outcomes. The current study evaluated the percentages of lymphocyte subsets by flowcytometry, SARS-CoV-2 specific T-cell immune response by ELISPOT, estimation of plasma cytokine/chemokine levels on a
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Sex-Specific Immune Responses to Seasonal Influenza Vaccination in Diabetic Individuals: Implications for Vaccine Efficacy J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-17 Anirban Sengupta, Noha Al-Otaibi, Jorma Hinkula
Seasonal influenza vaccination has different implications on the immune response depending on the comorbidities. Diabetes is one such critical disease that increases the patient’s susceptibility to influenza and suppresses vaccine efficacy and immunity. The sex of the individuals also plays a definitive role in the immune responses to both the vaccine and the infection. This study aims to understand
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A Review of Antibiotic Efficacy in COVID-19 Control J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-10 Hamidreza Hekmat, Aziz Rasooli, Zeinab Siami, Kauthar Amir Rutajengwa, Zahra Vahabi, Fatemeh Alsadat Mirzadeh
Severe acute respiratory disease is associated with chronic secondary infections that exacerbate symptoms and mortality. So far, many drugs have been introduced to treat this disease, none of which effectively control the coronavirus. Numerous studies have shown that mitochondria, as the center of cell biogenesis, are vulnerable to drugs, especially antibiotics. Antibiotics were widely prescribed during
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Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-9 Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, Ali A. Al-Jabri
Midkine (MK) and pleiotrophin (PTN) belong to the same family of cytokines. They have similar sequences and functions. Both have important roles in cellular proliferation, tumors, and diseases. They regulate and are expressed by some immune cells. We have recently demonstrated MK production by some human innate antigen-presenting cells (iAPCs), i.e., monocyte-derived dendritic cells (MDDCs) and macrophages
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The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome J. Immunol. Res. (IF 4.1) Pub Date : 2023-10-5 Yuanji Dong, Rongfen Gao, Kailin He, Jixin Zhong, Lingli Dong
Background. Macrophage activation syndrome (MAS) is a fatal inflammatory condition, which is often associated with the elevation of multiple proinflammatory cytokines and multiple organ dysfunction. Previous studies have shown that ST2 contributes to T cell overactivation and plays a detrimental role in mouse models of primary hemophagocytic lymphohistiocytosis. The purpose of this study was to investigate
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Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy J. Immunol. Res. (IF 4.1) Pub Date : 2023-9-27 Hanlu Shi, Liping Yang, Fujie Zhang, Yu Zhou, Yonglie Zhou
Rapid and accurate methods for the diagnosis of tuberculous pleurisy (TP) are urgently needed. Activation markers of tuberculosis (TB)–reactive T cells are considered promising for the diagnosis of active TB (ATB). Different activation indexes may play different roles in the progression of TB, but there are few reports on T cell activation indicators, except for HLA-DR. Hence, we evaluated the expression
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Alterations in the “Gut–Liver Axis” on Rats with Immunological Hepatic Fibrosis J. Immunol. Res. (IF 4.1) Pub Date : 2023-9-21 Zhaoyao Qi, Xinxin Qi, Yuanhui Xu, Hongguang Sun, Dengfeng Li, Jincun Liu, Meili Cong, Tao Liu
There remains a lack of standard models that have all the characteristics of human diseases. Especially in immunological hepatic fibrosis, the bovine serum albumin (BSA)-induced liver fibrosis models have the same developmental mechanisms as human liver fibrosis models, but have received little attention. We standardized a BSA-induced liver fibrosis model in rats and thoroughly assessed its pathological
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sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway J. Immunol. Res. (IF 4.1) Pub Date : 2023-9-20 Yatao Bao, Meng Lian, Yong Chen, Xiaotian Gu, Kunyu Cao, Xiaoping Du, Jiyu Ju
Genetic factors play an important role in the pathogenesis of systemic lupus erythematosus (SLE), and abnormal Toll-like receptor (TLR) signaling pathways are closely related to the onset of SLE. In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the
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Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1 J. Immunol. Res. (IF 4.1) Pub Date : 2023-9-19 Kunlong Zhang, Jun Lu, Fang Fang, Yongping Zhang, Juanjuan Yu, Yanfang Tao, Wenyuan liu, Lihui Lu, Zimu Zhang, Xinran Chu, Jianwei Wang, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Qian Li, Xu Sang, Li Ma, Ningling Wang, Jian Pan, Shaoyan Hu
Background. Arising from T progenitor cells, T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor, accounting for 15% of childhood ALL and 25% of adult ALL. Composing of putative enhancers in close genomic proximity, super enhancer (SE) is critical for cell identity and the pathogenesis of multiple cancers. Belonging to the cytosolute linker protein group, FYB1 is
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Dupilumab’s Impact on Blood Parameters in Nasal Polyposis: 18-Month Follow-Up in Real Life J. Immunol. Res. (IF 4.1) Pub Date : 2023-9-15 Antonella Loperfido, Andrea Ciofalo, Carlo Cavaliere, Elona Begvarfaj, Francesca Cascone, Giacomo Alfonzo, Rosalba Cadeddu, Stefano Millarelli, Gianluca Bellocchi, Antonio Greco, Marco de Vincentiis, Simonetta Masieri
Background. Dupilumab represents the first approved biological for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). Objective. Aim of this paper is to provide a multicentric real-life study about treatment with dupilumab for CRSwNP with a special focus on blood parameters and IgE, IgG, and IgA. Method. A retrospective data collection was jointly conducted at the Otolaryngology
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Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer J. Immunol. Res. (IF 4.1) Pub Date : 2023-9-9 Qianqian Wang, Chunxaing Feng, Yuchun Chen, Tianming Peng, Yong Li, Kunlin Wu, Xiaoyong Pu, Hanzhong Chen, Jiumin Liu
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells. Resistance to drugs and metastases are potential barriers for prostate cancer endocrine therapy. Although immunotherapy for tumors has developed rapidly in the last few decades, its effectiveness in treating
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Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target J. Immunol. Res. (IF 4.1) Pub Date : 2023-8-31 Hui-Yuan Li, Li-Feng Huang, Xiao-Rong Huang, Dan Wu, Xiao-Cui Chen, Ji-Xin Tang, Ning An, Hua-Feng Liu, Chen Yang
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism
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Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro J. Immunol. Res. (IF 4.1) Pub Date : 2023-8-31 Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh
Macrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the
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Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis J. Immunol. Res. (IF 4.1) Pub Date : 2023-8-25 Szabina Erdő-Bonyár, Diána Simon, Anna Bajnok, Jasper Nörenberg, Tímea Serény-Litvai, Ákos Várnagy, Kálmán Kovács, Eszter Hantosi, Emese Mezősi, Tímea Berki
T helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto’s thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early
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Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice J. Immunol. Res. (IF 4.1) Pub Date : 2023-8-24 Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan
Acetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in severe cases by triggering an inflammatory response and oxidative stress. Sesamin has been reported to possess anti-inflammatory and antioxidant actions in several animal disease models. In the present study, the effects and mechanisms of sesamin on APAP-induced acute liver injury (ALI) were explored. The results