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ERO1L Promotes Hepatic Metastasis through Activating Epithelial-Mesenchymal Transition (EMT) in Pancreatic Cancer J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-23 JianYu Yang; Yu Xu; YanMiao Huo; Li Cai; Rong Hua; JunFeng Zhang; Zhong Chen
Background. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) serves as an effector for tumor growth in human malignancies. However, the mechanism of ERO1L on promoting metastasis of pancreatic ductal adenocarcinoma (PDAC) remains to be further explored. Methods. Bioinformatics analysis of public databases and large-scale metastatic PDAC sequencing was performed to determine the expression profile
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Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-23 Rangarirai Makuku; Neda Khalili; Sepideh Razi; Mahsa Keshavarz-Fathi; Nima Rezaei
Cancer immunotherapy, which reactivates weakened immune cells of cancer patients, has yielded great success in recent years. Among immunotherapeutic agents, immune checkpoint inhibitors have been of particular interest and have gained approval by the FDA for treatment of cancers. Immune checkpoint blockade through targeting programmed cell death protein-1 (PD-1) has demonstrated promising antitumor
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Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-23 R. González-Stegmaier; K. Cereceda; J. L. Briones; C. Beltran-Pávez; A. Oyarzún-Arrau; S. Riquelme-Barrios; C. Selman; F. Yarad; M. Mahave; C. Caglevic; R. Morales; A. Aguirre; F. Valiente-Echeverría; R. Soto-Rifo; H. Marsiglia; R. Gazitua; F. Villarroel-Espindola
COVID-19 is a pandemic caused by SARS-CoV-2. In Chile, half a million people have been infected and more than 16,000 have died from COVID-19. As part of the clinical trial NCT04384588, we quantified IgG against S1-RBD of SARS-CoV-2 (anti-RBD) in recovered people in Santiago and evaluated their suitability as COVID-19 convalescent plasma donors. ELISA and a luminescent SARS-CoV-2 pseudotype were used
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IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-22 Khuloud Bajbouj; Mahmood Y. Hachim; Rakhee K. Ramakrishnan; Huwaida Fazel; Jumana Mustafa; Shahed Alzaghari; Mahmoud Eladl; Jasmin Shafarin; Ronald Olivenstein; Qutayba Hamid
Purpose. Asthma is one of the most common obstructive pulmonary diseases worldwide. Epigenetic alterations, including DNA methylation and histone modifications, have been reported to contribute to asthma pathogenesis. Since the inflammation mediator and remodeling trigger, IL-13, is known to play a central role in the pathophysiology of asthma, this study was aimed to identify novel IL-13-regulated
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Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-19 Dong Han; Jue Wang; Lulu Wen; Miao Sun; Hang Liu; Yan Gao
Aim. The protection against ischemia/reperfusion injury mediated by remote limb ischemic postconditioning (RIPC) shows great clinical value in ischemic stroke therapy, but the particular mechanism of RIPC remains unclear. Methods. We carried out middle cerebral artery occlusion/reperfusion (MCAO/R) surgery on C57BL/6 male mice. RIPC was generated by 10-minute occlusion followed by the same period of
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The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-19 Le-Bin Song; Jiao-Chen Luan; Qi-Jie Zhang; Lin Chen; Hao-Yang Wang; Xue-Chen Cao; Ning-Hong Song; Yan Lu
Background. Cutaneous melanoma is defined as one of the most aggressive skin tumors in the world. An increasing body of evidence suggested an indispensable association between immune-associated gene (IAG) signature and melanoma. This article is aimed at formulating an IAG signature to estimate prognosis of melanoma. Methods. 434 melanoma patients were extracted from The Cancer Genome Atlas (TCGA) database
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The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-19 Xin Xing; Yongrui Bai; Jian Song
The recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive. In this review, we discussed emerging research on the interaction between neutrophil recruitment and
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Low Distribution of TIM-3+ Cytotoxic Tumor-Infiltrating Lymphocytes Predicts Poor Outcomes in Gastrointestinal Stromal Tumors J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-18 Chun Zhuang; Bo Ni; Zi-Zhen Zhang; Wen-Yi Zhao; Lin Tu; Xin-Li Ma; Lin-Xi Yang; Hui Cao; Ming Wang
There are multiple tumor-infiltrating lymphocytes (TILs) and relevant immune checkpoints existing in gastrointestinal stromal tumor (GIST), which provides opportunities and rationales for developing effective immunotherapies. Recent studies have suggested that checkpoint TIM-3/Gal-9 plays a pivotal role on immune response in multiple tumors, similar to the PD-1/PD-L1, emerging as a potential therapeutic
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Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-18 Jéssica Adriana de Jesus; Márcia Dalastra Laurenti; Leila Antonangelo; Caroline Silvério Faria; João Henrique Ghilardi Lago; Luiz Felipe Domingues Passero
Leishmaniasis is a neglected tropical disease caused by the flagellated protozoa of the genus Leishmania that affects millions of people around the world. Drugs employed in the treatment of leishmaniasis have limited efficacy and induce local and systemic side effects to the patients. Natural products are an interesting alternative to treat leishmaniasis, because some purified molecules are selective
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Hypoxia-Induced Autophagy Enhances Cisplatin Resistance in Human Bladder Cancer Cells by Targeting Hypoxia-Inducible Factor-1α J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-17 Xiawa Mao; Nanzhang; Jiaquao Xiao; Huifeng Wu; Kefeng Ding
Purpose. To investigate the effect of hypoxia on chemoresistance and the underlying mechanism in bladder cancer cells. Methods. BIU-87 bladder cancer cell line was treated with cisplatin under hypoxic and normoxic conditions and tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, and Western blotting. All the data were expressed as from three independent
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Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-15 Junya Li; Hui Liu; Xinying Liu; Shengyu Hao; Zihan Zhang; Hongzhuan Xuan
Propolis is rich in flavonoids and has excellent antitumor activity. However, little is known about the potential effects of propolis on glycolysis in tumor cells. Here, the antitumor effects of propolis against human breast cancer MDA-MB-231 cells in an inflammatory microenvironment stimulated with lipopolysaccharide (LPS) were investigated by assessing the key enzymes of glycolysis. Propolis treatment
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Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-13 Khuloud Bajbouj; Rakhee K. Ramakrishnan; Qutayba Hamid
Asthma is a chronic airway disorder associated with aberrant inflammatory and remodeling responses. Angiogenesis and associated vascular remodeling are one of the pathological hallmarks of asthma. The mechanisms underlying angiogenesis in asthmatic airways and its clinical relevance represent a relatively nascent field in asthma when compared to other airway remodeling features. Matrix metalloproteinases
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Moesin Is a Novel Biomarker of Endothelial Injury in Sepsis J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-13 Yikun Chen; Jiajia Wang; Lei Zhang; Jianjie Zhu; Yuanyuan Zeng; Jian-an Huang
Objective. Increased vascular permeability and inflammation are principal hallmark of sepsis. Moesin (MSN) is a membrane-associated cytoskeleton protein and crucial for the vascular endothelial function. This study is aimed at evaluating the role of MSN in endothelial injury during the process of sepsis. Methods. Serum MSN in septic patients was measured by ELISA. BALB/c mice were injected with different
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Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-12 Yaroslav V. Radzyukevich; Ninel I. Kosyakova; Isabella R. Prokhorenko
Systemic inflammation plays a crucial role in formation of various pathological conditions, including sepsis, burns, and traumas. The main effector cells participating in progression of systemic inflammation response and sepsis are monocytes, which regulate both innate and acquired immunity via phagocytosis, synthesis of cytokines and chemokines, antigen presentation, and lymphocyte activation. Thus
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Identification of a New Prognostic Risk Signature of Clear Cell Renal Cell Carcinoma Based on N6-Methyladenosine RNA Methylation Regulators J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-12 Yan Zhang; Yao Yao; Xiaochen Qi; Jianyi Li; Meihong Liu; Xiangyu Che; Yingkun Xu; Guangzhen Wu
As the most prevalent internal eukaryotic modification, N6-methyladenosine (m6A) is installed by methyltransferases, removed by demethylases, and recognized by readers. However, there are few studies on the role of m6A in clear cell renal cell carcinoma (ccRCC). In this study, we researched the RNA-seq transcriptome data of ccRCC in the TCGA dataset and used bioinformatics analyses to detect the relationship
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CDK12 Promotes Cervical Cancer Progression through Enhancing Macrophage Infiltration J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-11 Bikang Yang; Jing Chen; Yincheng Teng
Cervical cancer (CC) is a commonly diagnosed and primary consideration of cancer patient death in female reproductive system malignancy. Cyclin-dependent kinase 12 (CDK12), as a transcription-associated CDK, plays important roles in tumor-promoting behaviors, whereas the underlying mechanisms of CDK12 in CC progression are still obscure. In this report, we investigated the role of CDK12 in cervical
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The Role of β-Catenin in Th1 Immune Response against Tuberculosis and Profiles of Expression in Patients with Pulmonary Tuberculosis J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-11 Kunlong Xiong; Jinxia Niu; Ruijuan Zheng; Zhonghua Liu; Yanzheng Song; Lin Wang; Changtai Zhu; Lin Fan
β-Catenin is a key molecule of canonical Wnt/β-catenin pathway. Its roles and expression profiles in T cells of tuberculosis (TB) remain unclear. The aim of this study was to explore the role of β-catenin in CD4+ T cells and its expression characteristics in patients with pulmonary tuberculosis (PTB). In this study, CD4+ T cell-specific β-catenin conditional knockout mice (β-CAT-cKO mice) were aerosol
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Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-11 Qian Yang; Guowei Huang; Liyan Li; Enmin Li; Liyan Xu
Colorectal cancer (CRC) has two major subtypes, microsatellite instability (MSI) and microsatellite stability (MSS) based on the genomic instability. In this study, using computational programs, we identified 9 master transcription factors (TFs) based on epigenomic profiling in MSS CRC samples. Notably, unbiased gene set enrichment analysis (GSEA) showed that several master TFs were strongly associated
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Application of Bionanomaterials in Tumor Immune Microenvironment Therapy J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-11 Jiawei Wang; Yan Bao; Yandan Yao
Targeted therapy for the cancer immune system has become a clinical reality with remarkable success. Immune checkpoint blockade therapy and chimeric antigen receptor T-cell (CAR-T) immunotherapy are clinically effective in a variety of cancers. However, the clinical utility of immunotherapy in cancer is limited by severe off-target toxicity, long processing time, limited efficacy, and extremely high
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-10 Qian Yang; Ruijing Zhang; Peng Tang; Yu Sun; Candice Johnson; Jason Saredy; Susu Wu; Jiwei Wang; Yifan Lu; Fatma Saaoud; Ying Shao; Charles Drummer; Keman Xu; Daohai Yu; Rongshan Li; Shuping Ge; Xiaohua Jiang; Hong Wang; Xiaofeng Yang
Background. The immune mechanisms underlying low-intensity ultrasound- (LIUS-) mediated suppression of inflammation and tumorigenesis remain poorly determined. Methods. We used microarray datasets from the NCBI GEO DataSet repository and conducted comprehensive data-mining analyses, where we examined the gene expression of 1376 innate immune regulators (innatome genes (IGs) in cells treated with LIUS
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Comparison of Blood and Tissue Eosinophil Count and Blood IgE in Patients with Chronic Sinusitis and Nasal Polyps J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-10 Masoud Asghari; Shadi Izadpanahi; Mina Heidari Esfahani
Background. The inflammatory mucosa of the sinus cavities is called sinusitis and is divided into various types based on its appearance and sign. Chronic rhinosinusitis is an inflammatory-infectious disease that involves the frontal, sphenoid, ethmoid, and maxillary sinuses. Chronic sinusitis is a multifactorial disease and the range of causes varies from environmental factors to genetic factors. The
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Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-09 Youxiang Zhang; De-Hui Xiong; Yangyang Li; Guina Xu; Baoxin Zhang; Yang Liu; Shan Zhang; Qing Huang; Simin Chen; Fansheng Zeng; Jingyi Guo; Bin Li; Zhiqiang Qin; Zuping Zhang
The E3 deubiquitinating enzyme ubiquitin-specific proteolytic enzyme 21 (USP21) plays vital roles in physiological activities and is required for Treg-cell-mediated immune tolerance. Using a murine model infected with Schistosoma japonicum, we observed that there were more cercariae developed into adults and more eggs deposited in the livers of the USP21fl/flFOXP3Cre (KO) mice. However, immunohistochemistry
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Impact of IL-1Ra Gene Polymorphism on the Etiology and Fate of Disease in Children with Immune Thrombocytopenic Purpura J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-09 Bizav Naji Rasheed; Adil Abozaid Eissa
Background. Immune thrombocytopenic purpura (ITP) is considered to be one of the common childhood autoimmune diseases, and the current study was initiated to study the effect of various factors, particularly interleukin 1 receptor antagonist (IL-1Ra) gene polymorphism, on the course of the disease. Methods. The current case-control study involved 60 newly diagnosed children presented with ITP (also
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Clinical Implications of Exosomal PD-L1 in Cancer Immunotherapy J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-09 Sergio Ayala-Mar; Javier Donoso-Quezada; José González-Valdez
Inhibiting the programmed cell death ligand-1 (PD-L1)/programmed cell death receptor-1 (PD-1) signaling axis reinvigorates the antitumor immune response with remarkable clinical efficacy. Yet, low response rates limit the benefits of immunotherapy to a minority of patients. Recent studies have explored the importance of PD-L1 as a transmembrane protein in exosomes and have revealed exosomal PD-L1 as
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p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway J. Immunol. Res. (IF 3.327) Pub Date : 2021-02-01 Qingli Lu; Yuanyuan Qu; Yuan Ding; Xiaojing Kang
Basal cell carcinoma (BCC) is the most common skin cancer. While most of the basal cell carcinomas were localized lesion and can be easily managed, the treatment options to the advanced basal cell carcinomas are still remarkably limited. In recent years, proBDNF and its receptor p75NTR have been reported to play important roles in various diseases, including cancers and psychotic disorders. However
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Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-31 Jiao Fan; Yang Liu; Yiping Zhong
Anticentromere antibodies (ACA) were associated with lower oocyte maturation rates and cleavage rates, while the mechanism was not clear. Aims of this study were to examine whether active immunization with centromere protein C could elicit the CENP-C autoantibody in mice and the impacts of the CENP-C autoantibody on oocyte meiosis. Mice were divided into two groups, one was the experimental group immunized
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High-Expressed Macrophage Scavenger Receptor 1 Predicts Severity Clinical Outcome in Transplant Patient in Idiopathic Pulmonary Fibrosis Disease J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-31 Mingfeng Zheng; Tian Tian; Jialong Liang; Shugao Ye; Jingyu Chen; Yong Ji
Background. Lung transplantation has been performed worldwide and admitted as an effective treatment for patients with various end-stage lung diseases. However, limit reliable clinical indicators exist to identify patients at high risk for allograft failure in lung transplant recipients. The recent advances in the knowledge of immunological aspects of the pulmonary diseases, for that innate macrophage
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Aberrant Expression of a Proliferation-Inducing Ligand Underlies Autoimmune Mechanisms in Immune Thrombocytopenia J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-30 Y. F. Hao; H. Bi; H. Y. Li; L. M. Yin; J. X. Yu; W. Tao; H. L. Mu; R. C. Yang; W. L. Tai; Z. P. Zhou
Purpose. To study the relationship between surface membrane-bound APRIL and ITP. Methods. The peripheral blood of all subjects, 50 patients diagnosed with ITP and 25 healthy controls, was collected. Flow cytometry was used to detect the expression of membrane-bound APRIL on immune cells and platelets. ELISA was used to detect the content of soluble APRIL in plasma. Results. Membrane-bound APRIL was
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The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-29 Krzysztof Orczyk; Elzbieta Smolewska
Small, noncoding sequences of ribonucleic acid called microRNAs (miRNAs, miR) are functioning as posttranscriptional regulators of gene expression. As they draw increasing attention of rheumatologists, there is a growing body of evidence concerning specific molecules that may affect the long-term care of patients with inflammatory arthritides. Findings involving children with juvenile idiopathic arthritis
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Efficacy of Rg1-Oil Adjuvant on Inducing Immune Responses against Bordetella bronchiseptica in Rabbits J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-29 Xiao Chenwen; Ji Quanan; Huang Yee; Liu Yan; Wang Jiaoyu; Wei Qiang; Qiao Litao; Nan Li; Bao Guolian
Bordetella bronchiseptica (B. bronchiseptica) is an obligately aerobic, oxidase- and catalase-positive, nonfermentative Gram-negative coccobacillus. This study is aimed at examining the immune effects of Rg1, Rg1 plus oil, and other common adjuvants on inactivated B. bronchiseptica vaccine in rabbits. The mechanism underlying the adjuvant effect of Rg1 plus oil on the vaccine was also explored. Rg1
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Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-28 Nils Becker; Philipp Störmann; Andrea Janicova; Kernt Köhler; Klemens Horst; Ildiko Rita Dunay; Claudia Neunaber; Ingo Marzi; Jan Tilmann Vollrath; Borna Relja
Background. Recently, identification of immunosuppressive polymorphonuclear leukocytes (PMNL) that were traditionally described as proinflammatory cells emerged in the field of posttraumatic immunity. To understand their local and remote distribution after trauma, PMNL-subsets and the impact of immunomodulatory Club Cell protein (CC)16 that correlates with pulmonary complications were assessed. Methods
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Retinal and Choroidal Thickness in relation to C-Reactive Protein on Swept-Source Optical Coherence Tomography J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-25 Dawei Fang; Qingjian Li; Ke Yan; Sennan Xu; Jing Jiang; Xin Che; Yu Zhang; Yiwen Qian; Zhiliang Wang
Purpose. To evaluate the relationships between C-reactive protein (CRP) and retinal and choroidal thickness by swept-source optical coherence tomography (SS-OCT). Methods. The participants included in the prospective cross-sectional study underwent a comprehensive ophthalmic examination. Based on the CRP values, the subjects were divided into the CRP (+) group ( mg/L) and the CRP (−) group ( mg/L)
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Th17 Cells in Inflammatory Bowel Disease: Cytokines, Plasticity, and Therapies J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-22 Junjun Zhao; Qiliang Lu; Yang Liu; Zhan Shi; Linjun Hu; Zhi Zeng; Yifeng Tu; Zunqiang Xiao; Qiuran Xu
Autoimmune diseases (such as rheumatoid arthritis, asthma, autoimmune bowel disease) are a complex disease. Improper activation of the immune system or imbalance of immune cells can cause the immune system to transform into a proinflammatory state, leading to autoimmune pathological damage. Recent studies have shown that autoimmune diseases are closely related to CD4+ T helper cells (Th). The original
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Involvement of CD26 in Differentiation and Functions of Th1 and Th17 Subpopulations of T Lymphocytes J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-21 Xiangli Zhao; Wenhan Wang; Kai Zhang; Jingya Yang; Hendrik Fuchs; Hua Fan
CD26, acting as a costimulator of T cell activation, plays an important role in the immune system. However, the role of CD26 in the differentiation of T cell subsets, especially of new paradigms of T cells, such as Th17 and Tregs, is not fully clarified. In the present study, the role of CD26 in T cell differentiation was investigated in vitro. CD26 expression was analyzed in the different subsets
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Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-19 Charles Elias Assmann; Vitor Bastianello Mostardeiro; Grazielle Castagna Cezimbra Weis; Karine Paula Reichert; Audrei de Oliveira Alves; Vanessa Valéria Miron; Margarete Dulce Bagatini; Taís Vidal Palma; Cinthia Melazzo de Andrade; Micheli Mainardi Pillat; Fabiano Barbosa Carvalho; Cristina Ruedell Reschke; Ivana Beatrice Mânica da Cruz; Maria Rosa Chitolina Schetinger; Vera Maria Melchiors Morsch
Aluminum (Al) is ubiquitously present in the environment and known to be a neurotoxin for humans. The trivalent free Al anion (Al3+) can cross the blood-brain barrier (BBB), accumulate in the brain, and elicit harmful effects to the central nervous system (CNS) cells. Thus, evidence has suggested that Al increases the risk of developing neurodegenerative diseases, particularly Alzheimer’s disease (AD)
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Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-18 Shangzhu Zhang; Meng Li; Li Zhang; Ziqian Wang; Qiang Wang; Hui You; Yanhong Wang; Mengtao Li; Xiaofeng Zeng
Objective. To identify the clinical characteristics, magnetic resonance imaging (MRI) results, and prognostic factors of neuropsychiatric (NP) systemic lupus erythematosus (SLE; NPSLE) in a relatively large patient series in China. Methods. Data of patients with NPSLE at Peking Union Medical College Hospital (PUMCH) were collected retrospectively from June 2012 to June 2016. NPSLE patients were compared
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Yangxue Jiedu Fang Ameliorates Psoriasis by Regulating Vascular Regression via Survivin/PI3K/Akt Pathway J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-18 Hongpeng Lv; Xin Liu; Weiwen Chen; Shiju Xiao; Yunrun Ji; Xuyang Han; Yafan Li; Xiaoxu Wang; Guangzhong Zhang; Ping Li
Background. Psoriasis (PA) is a chronic autoimmune disease of the skin that adversely affects patients’ quality of life. Yangxue Jiedu Fang (YXJD) has been used for decades to treat psoriasis in China. However, its antipsoriatic mechanisms are still poorly understood. In this study, we explored the effects of YXJD on angiogenesis and apoptosis of microvessels in PA, the underlying mechanisms in HUVEC
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Identification of the Different Gene Expression Characteristics from Liver Cirrhosis to Hepatocellular Carcinoma Using Single-Cell Sequencing Analyses J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-18 Xin Xing; Jian Song
The occurrence of hepatocellular carcinoma (HCC) is closely related to the chronic inflammation which caused liver fibrosis and cirrhosis, and the interaction between HCC and its microenvironment further drives tumorigenesis. However, the single-cell resolution in vivo study is lacking, which limits our molecular understanding of tumour biology in the liver. Here, using published single-cell sequencing
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Keyhole Limpet Hemocyanin-Conjugated Peptides from Hepatitis C Virus Glycoproteins Elicit Neutralizing Antibodies in BALB/c Mice J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-18 Kai Deng; Zhanxue Xu; Mingxiao Chen; Xiaoxiang Liu
Currently, no vaccine to prevent hepatitis C virus (HCV) infection is available. A major challenge in developing an HCV vaccine is the high diversity of HCV sequences. The purpose of immunization with viral glycoproteins is to induce a potent and long-lasting cellular and humoral immune response. However, this strategy only achieves limited protection, and antigen selection plays a crucial role in
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Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-18 Ke Xie; Yu-sen Chai; Shi-hui Lin; Fang Xu; Chuan-jiang Wang
Objectives. Inflammatory disease characterized by clinical destructive respiratory disorder is called acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Studies have shown that luteolin exerts anti-inflammatory effects by increasing regulatory T cells (Tregs). In this study, we aimed to determine the effects of luteolin on ALI/ARDS and Treg differentiation. Methods. In this paper, we
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Chinese Traditional Medicine NiuBeiXiaoHe (NBXH) Extracts Have the Function of Antituberculosis and Immune Recovery in BALB/c Mice J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-18 Yan Liang; Wenping Gong; Xiaomei Wang; Junxian Zhang; Yanbo Ling; Jinying Song; Lan Wang; Xiao Liu; Jie Wang; Yourong Yang; Shibing Chen; Jun Liu; Chunwei Yang; Huafeng Luo; Xueqiong Wu
Background. The Traditional Chinese Medicine NiuBeiXiaoHe (NBXH) is a valid antituberculosis (TB) prescription from the experience of clinical practice. However, the mechanism of NBXH extracts’ immunotherapy has been poorly understood. Herein, the immunotherapeutic efficacy and the differentially expressed (DE) genes of NBXH extracts were evaluated and identified in BALB/c mice. Methods. The total
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Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-13 Kagoué Simeni Luc-Aimé; Yindom Louis-Marie; Loni Ekali Gabriel; Clauvis Kunkeng Yengo; F. Esemu Livo; Nguedia Jules Clement Assob
The biological reason(s) behind persistent mother-to-child transmission (MTCT) of HIV (albeit at reduced rate compared to the preantiretroviral therapy era) in spite of the successful implementation of advanced control measures in many African countries remains a priority concern to many HIV/AIDS control programs. This may be partly due to differences in host immunogenetic factors in highly polymorphic
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New Biomarker in Chagas Disease: Extracellular Vesicles Isolated from Peripheral Blood in Chronic Chagas Disease Patients Modulate the Human Immune Response J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-12 Rafael Pedro Madeira; Lavínia Maria Dal’Mas Romera; Paula de Cássia Buck; Charles Mady; Barbara Maria Ianni; Ana Claudia Torrecilhas
Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan Trypanosoma cruzi (T. cruzi), is a major public health problem. It was initially restricted to Latin America, but it is now expanding globally. Host and pathogen interactions are crucial in the establishment of disease, and since 1970, it has been known that eukaryotic cells release extracellular vesicles (EVs),
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High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-09 Hao Liu; Zhenzhan Zhang; Peilin Zhen; Meijuan Zhou
Background. Preoperative chemoradiotherapy (pCRT) is a common and essential therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor response and therapeutic resistance to chemoradiotherapy have appeared usually among persons and affected those patients’ survival prognosis. The resistance to chemoradiotherapy in rectal cancer is difficult to predict. This study was
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Identification of Immune-Related Prognostic Biomarkers Associated with HPV-Positive Head and Neck Squamous Cell Carcinoma J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-08 Yifei Chen; Jin Nie; Xiangsheng Li; Tao Fan; Xiaowen Deng; Dan Liang; Guilin Song
Background. As a type of malignant tumor, head and neck squamous cell carcinoma (HNSCC) seriously threatens human health. This study is aimed at constructing a new, reliable prognostic model. Method. The gene expression profile data of HNSCC patients were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas databases. The immune-related differentially expressed genes (IRDEGs) related
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Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-08 Yanran Huang; Ming Wang; Yu Hong; Xiangting Bu; Ge Luan; Yang Wang; Ying Li; Hongfei Lou; Chengshuo Wang; Luo Zhang
Introduction. Antimicrobial peptides and proteins (AMPs) constitute the first line of defense against pathogenic microorganisms in the airway. The association between AMPs and chronic rhinosinusitis with nasal polyps (CRSwNP) requires further investigations. This study is aimed at investigating the expression and regulation of major dysregulated AMPs in the nasal mucosa of CRSwNP. Methods. The expression
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The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-08 Yuan Li; Sheng-Xiao Zhang; Xu-Fang Yin; Ming-Xing Zhang; Jun Qiao; Xiao-Hong Xin; Min-Jing Chang; Chong Gao; Ya-Feng Li; Xiao-Feng Li
Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut microbiome critically contribute to the development of rheumatoid arthritis (RA). Previous studies demonstrated the disturbance of lymphocyte subpopulations in RA patients. The purpose of this study was to explore the characteristics of gut microbiome and the associations between bacterium and lymphocyte
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Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-07 Nilberto Dias de Araújo; Fábio Magalhães Gama; Mateus de Souza Barros; Thaís Lohana Pereira Ribeiro; Fabíola Silva Alves; Lilyane Amorim Xabregas; Andréa Monteiro Tarragô; Adriana Malheiro; Allyson Guimarães Costa
Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell
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Protective Effects of Chicken Egg Yolk Immunoglobulins (IgYs) against Vibrio vulnificus Infections J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-07 Ruizhao Cai; Ning Liu; Penghao Guo; Kang Liao; Mengzhi Li; Junyou Zhu; Shouyi Chen; Lei Chen; Bin Shu; Shaohai Qi
Vibrio (V.) vulnificus infection is a rare disease whose death rates exceed 50% despite aggressive antibiotic treatment and surgical debridement. The aim of this study was to assess the ability of specific anti-V. vulnificus immunoglobulins Y (IgYs) for preventing and treating V. vulnificus infections. IgYs were produced by immunizing egg laying hens with inactivated whole cell bacteria. Peritoneal
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Determining Factors in the Therapeutic Success of Checkpoint Immunotherapies against PD-L1 in Breast Cancer: A Focus on Epithelial-Mesenchymal Transition Activation J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-07 Mariana Segovia-Mendoza; Susana Romero-Garcia; Cristina Lemini; Heriberto Prado-Garcia
Breast cancer is the most common neoplasm diagnosed in women around the world. Checkpoint inhibitors, targeting the programmed death receptor-1 or ligand-1 (PD-1/PD-L1) axis, have dramatically changed the outcome of cancer treatment. These therapies have been recently considered as alternatives for treatment of breast cancers, in particular those with the triple-negative phenotype (TNBC). A further
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Correlation of Indoleamine-2,3-Dioxygenase and Chronic Kidney Disease: A Pilot Study J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-06 Binbin Pan; Feng Zhang; Jian Sun; Dawei Chen; Wenjuan Huang; Hao Zhang; Changchun Cao; Xin Wan
Objective. To explore the correlation of indoleamine-2,3-dioxygenase (IDO) and chronic kidney disease (CKD). Methods. A total of 154 CKD patients and 42 non-CKD patients were recruited. Patients were grouped into ACR1~ACR3 (<30 mg/g, 30-300 mg/g, and >300 mg/g). Biomarkers in different groups were compared by ANOVA. Correlation was calculated by Pearson or Spearman analysis and binary logistic regression
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Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis J. Immunol. Res. (IF 3.327) Pub Date : 2021-01-05 Yan Lin; Yu Dong; Yanfeng Gao; Ranran Shi; Yubing Li; Xiuman Zhou; Wenwen Liu; Guodong Li; Yuanming Qi; Yahong Wu
Tuberculosis is the world’s most deadly infectious disease, with 10 million people falling ill and 1.5 million people dying from the disease every year. With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence of coinfection of MTB with human immunodeficiency virus, many challenges remain in the prevention and treatment of tuberculosis. Therefore, the development
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DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration J. Immunol. Res. (IF 3.327) Pub Date : 2020-12-31 Yanni Xu; Qiongchao Jiang; Hejun Liu; Xiaoyun Xiao; Dinghong Yang; Phei Er Saw; Baoming Luo
Background. RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biological functions of RNA helicase DHX37 in cancers. Objective. We aim to identify the
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Selenium Nanoparticles Induce Potent Protective Immune Responses against Vibrio cholerae WC Vaccine in a Mouse Model J. Immunol. Res. (IF 3.327) Pub Date : 2020-12-30 Zahra Raahati; Bita Bakhshi; Shahin Najar-peerayeh
The aim of this study was to evaluate the efficacy of selenium nanoparticle (an immune booster) and naloxone (an opioid receptor antagonist) as a new adjuvant in increasing immune responses against killed whole-cell Vibrio cholerae in a mouse cholera model. The Se NPs were synthesized and characterized by UV-visible, DLS, and zeta potential analysis. The SEM image confirmed the uniformity of spherical
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Tumor-Infiltrating Immune Cells and PD-L1 as Prognostic Biomarkers in Primary Esophageal Small Cell Carcinoma J. Immunol. Res. (IF 3.327) Pub Date : 2020-12-29 Xiao Wu; Xiurong Ke; Yangpeng Ni; Liping Kuang; Fan Zhang; Yusheng Lin; Wan Lin; Xiao Xiong; Haihua Huang; Xianjie Lin; Hao Zhang
Primary esophageal small cell carcinoma (PESCC) is a weakly prevalent but lethal malignancy with early metastasis and a poor prognosis. Currently, neither effective prognostic indicators nor curative therapies are available for PESCC. Immunotherapy has now evolved into one of the most promising therapies for cancer patients. Tumor-infiltrating immune cells which are integral to the tumor immune microenvironment
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Development of an Immunoassay for the Detection of Amyloid Beta 1-42 and Its Application in Urine Samples J. Immunol. Res. (IF 3.327) Pub Date : 2020-12-28 Anurak Wongta; Surat Hongsibsong; Somporn Chantara; Mookda Pattarawarapan; Ratana Sapbamrer; Korawan Sringarm; Zhen-Lin Xu; Hong Wang
Amyloid beta peptides (Aβ1-42) have been found to be associated with the cause of Alzheimer’s disease (AD) and dementia. Currently, methods for detecting Aβ1-42 are complicated and expensive. The present study is aimed at developing an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) to detect Aβ1-42 by using a polyclonal antibody from alpaca, an application used in urine samples.
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miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes J. Immunol. Res. (IF 3.327) Pub Date : 2020-12-28 Dina Salem Fotoh; Rasha Ibrahim Noreldin; Mohamed Soliman Rizk; Maha Mohamed Elsabaawy; Heba Ahmed Esaily
Background. Early diagnosis of ankylosing spondylitis (AS) is yet not elucidated, with a potential diagnostic glance of microRNAs (miRNAs). Aim. Study the expression profile of miRNA-451a and miRNA-125a in AS patients and their impact on disease activity and prognosis. Methods. A cross-sectional study included 55 AS patients diagnosed according to modified New York criteria in 1984 with 55 matched