样式: 排序: IF: - GO 导出 标记为已读
-
The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-15 Kui Wang, Suijian Wang, Xianzheng Qin, Yifei Chen, Yuhua Chen, Jiawei Wang, Yao Zhang, Qiang Guo, Chunhua Zhou, Duowu Zou
BackgroundGrowing evidence has shown that gut microbiome composition is associated with Biliary tract cancer (BTC), but the causality remains unknown. This study aimed to explore the causal relationship between gut microbiota and BTC, conduct an appraisal of the gut microbiome’s utility in facilitating the early diagnosis of BTC.MethodsWe acquired the summary data for Genome-wide Association Studies
-
Rapid duplex flap probe-based isothermal assay to identify the Cryptococcus neoformans and Cryptococcus gattii Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-15 Xin Ye, Lei Zhang, Qingqing Yang, Weihua Pan, Xiaoyan Zeng
Cryptococcosis is a life-threatening invasive fungal infection with significantly increasing mortality worldwide, which is mainly caused by Cryptococcus neoformans and Cryptococcus gattii. These two species complexes have different epidemiological and clinical characteristics, indicating the importance of accurate differential diagnosis. However, the clinically used culture method and cryptococcal
-
Intestinal microbiota and biliary system diseases Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-15 Hua Wang, Junfeng Gong, Jingyi Chen, Wei Zhang, Yanjun Sun, Dengqun Sun
IntroductionThe incidence of biliary system diseases has been continuously increasing in the past decade. Biliary system diseases bring a heavy burden to humanity and society. However, the specific etiology and pathogenesis are still unknown. The biliary system, as a bridge between the liver and intestine, plays an indispensable role in maintaining the physiological metabolism of the body. Therefore
-
Plasma metabolomic profile is near-normal in people with HIV on long-term suppressive antiretroviral therapy Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-14 Ana Virseda-Berdices, Rubén Martín-Escolano, Juan Berenguer, Juan González-García, Oscar Brochado-Kith, David Rojo, Amanda Fernández-Rodríguez, Leire Pérez-Latorre, Victor Hontañón, Coral Barbas, Salvador Resino, María Ángeles Jiménez-Sousa
BackgroundCombination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression and satisfactory immunological recovery. We aimed to determine whether the plasma metabolomic profile of PWH on long-term suppressive ART and immunologically
-
Causal associations between Helicobacter pylori infection and pregnancy and neonatal outcomes: a two-sample Mendelian randomization study Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-14 Jialyu Huang, Yuxin Liu, Dingfei Xu, Mengyi Chen, Qiqi Xie, Jia Chen, Leizhen Xia, Lamei Yu, Qiongfang Wu, Zengming Li, Jiawei Wang, Lifeng Tian
BackgroundObservational studies have reported that Helicobacter pylori (H. pylori) infection is associated with a series of pregnancy and neonatal outcomes. However, the results have been inconsistent, and the causal effect is unknown.MethodsA two-sample Mendelian randomization (MR) study was performed using summary-level statistics for anti-H. pylori IgG levels from the Avon Longitudinal Study of
-
Vaginal dysbiosis seems associated with hrHPV infection in women attending the Dutch Cervical Cancer Screening Program Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-13 Anne J. M. Loonen, Femke Verhagen, Ilse Luijten-de Vrije, Marjolein Lentjes-Beer, Cornelis J. Huijsmans, Adriaan J. C. van den Brule
Human papillomavirus (HPV) is a sexually transmitted virus, which infects approximately 80% of all men and women at some time in their lives. Usually, the infection is resolved successfully by the body’s immune system. Persistent infection with high-risk HPV (hrHPV) is necessary but not sufficient for cervical cancer development, and additional factors, such as the vaginal microbiome (vaginome), are
-
Adaptation to an amoeba host drives selection of virulence-associated traits and genetic variation in saprotrophic Candida albicans Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-13 Artid Amsri, Kritsada Pruksaphon, Patcharin Thammasit, Joshua D. Nosanchuk, Sirida Youngchim
Amoebae are micropredators that play an important role in controlling fungal populations in ecosystems. However, the interaction between fungi and their amoebic predators suggests that the pressure from predatory selection can significantly influence the development of fungal virulence and evolutionary processes. Thus, the purpose of this study was to investigate the adaptation of saprotrophic Candida
-
Small RNA-modulated anaerobic respiration allows bacteria to survive under antibiotic stress conditions Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-13 Dajeong Kim, Abhayprasad Bhat, Seon-Kyu Kim, Soohyun Lee, Choong-Min Ryu
Despite extensive knowledge of antibiotic-targeted bacterial cell death, deeper understanding of antibiotic tolerance mechanisms is necessary to combat multi-drug resistance in the global healthcare settings. Regulatory RNAs in bacteria control important cellular processes such as cell division, cellular respiration, metabolism, and virulence. Here, we investigated how exposing Escherichia coli to
-
Altered ocular surface microbiota in obesity: a case-control study Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 Chenghong Liang, Limin Wang, Xiudan Wang, Yifan Jia, Qinyuan Xie, Lingyun Zhao, Huijuan Yuan
PurposeThis study aimed to investigate the composition of ocular surface microbiota in patients with obesity.MethodsThis case-control study, spanning from November 2020 to March 2021 at Henan Provincial People’s Hospital, involved 35 patients with obesity and an equivalent number of age and gender-matched healthy controls. By employing 16S rRNA sequencing, this study analyzed the differences in ocular
-
Clinical efficacy of probiotics in the treatment of alcoholic liver disease: a systematic review and meta-analysis Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 Shi-Ying Xiong, Gui-Sheng Wu, Chun Li, Wenzhe Ma, Huai-Rong Luo
ObjectiveAlcoholic liver disease (ALD) is a liver damage disease caused by long-term heavy drinking. Currently, there is no targeted pharmaceutical intervention available for the treatment of this disease. To address this, this paper evaluates the efficacy and safety of probiotic preparation in treating ALD through conducting a meta-analysis, and provides a valuable insight for clinical decision-making
-
Alteration in gut microbiota is associated with immune imbalance in Graves’ disease Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 Yalei Liu, Shasha Tang, Yu Feng, Binghua Xue, Chaofei Cheng, Yong Su, Wei Wei, Lijun Zhang, Zhoufeng Huang, Xiaoyang Shi, Yuanyuan Fang, Junpeng Yang, Yun Zhang, Xinru Deng, Limin Wang, Hongyan Ren, Chongjian Wang, Huijuan Yuan
BackgroundGraves’ disease (GD), characterized by immune aberration, is associated with gut dysbiosis. Despite the growing interest, substantial evidence detailing the precise impact of gut microbiota on GD’s autoimmune processes remains exceedingly rare.ObjectiveThis study was designed to investigate the influence of gut microbiota on immune dysregulation in GD.MethodsIt encompassed 52 GD patients
-
Differential responses to avian pathogenic E. coli and the regulatory role of splenic miRNAs in APEC infection in Silkie chickens Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 Wenqing Li, Wanli Li, Pinhui Wu, Wei Jin, Lin Yuan, Bingxun Wang, Shengli Li, Xiangtao Kang
Avian pathogenic Escherichia coli (APEC) is a bacterial disease that harms the poultry industry worldwide, but its effect on Chinese Silkie has not been reported. Studies on whether there are differences in Silkie individual resistance to APEC and the regulatory role of spleen miRNAs lay the foundation for strategies against APEC. Therefore, 270 Silkie chickens were infected with the median lethal
-
Genotyping of ticks: first molecular report of Hyalomma asiaticum and molecular detection of tick-borne bacteria in ticks and blood from Khyber Pakhtunkhwa, Pakistan Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 Muhammad Kashif Obaid, Shehla Shehla, Guiquan Guan, Muhammad Rashid, Sumaira Shams
Multiple ticks (Acari: Ixodoidea) carrying Rickettsiales bacteria have significant importance for both human and animal health. Thus, the purpose of this work was to genetically analyze tick species and their associated Rickettsiales bacteria in animal hosts. In order to achieve these objectives, various animals (including camels, cattle, goats, sheep, dogs, and mice) were inspected in four districts
-
Brucella infection and Toll-like receptors Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 Hui Yu, Xinyi Gu, Danfeng Wang, Zhanli Wang
Brucella consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis. Toll-like receptors (TLRs) are the best-known sensors of microorganisms implicated in the regulation of innate and adaptive immunity. In particular, TLRs are transmembrane proteins
-
The interplay between HPV, other Sexually Transmissible Infections and genital microbiome on cervical microenvironment (MicroCervixHPV study) Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-12 J. Guilherme Gonçalves-Nobre, Andreia Matos, Mariana Carreira, Ana Carolina Santos, Luisa Carvalho Veiga, Catarina Ginete, Miguel Brito, Marina Pires, Hermínia Pereira, Carlos Cardoso, Manuel Bicho, Maria Clara Bicho
BackgroundThe importance of Cervicovaginal Microbiota in protecting against infections (such as HPV) is already well established, namely through Lactobacillus spp., as well as the mechanism through which HPV leads to Cervical Neoplasia. However, it is not possible to classify HPV as a complete carcinogen. Thus, the importance of exploring Cervicovaginal dysbiosis with the intention of deciphering this
-
PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-11 Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Valentina Dell’Oste
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in multiple diseases, including cancer. Given that high-risk (hr) human papillomaviruses (HPVs) are the etiological agents of cervical cancer, in this study,
-
Spectrum and antibiotic sensitivity of bacterial keratitis: a retrospective analysis of eight years in a Tertiary Referral Hospital in Southwest China Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-11 Rui-Qin Guo, Ji Yang, Ya-Bin Yang, Ya-Nan Chen, Yu-Yuan Xiao, Ping Xiang, Meng-Jie Dong, Min-Fang He, Yin-Ting Wang, Yun-Ling Xiao, Hong-Qin Ke, Hai Liu
PurposeThe objective of this study was to investigate the epidemiological characteristics, distribution of isolates, prevailing patterns, and antibiotic susceptibility of bacterial keratitis (BK) in a Tertiary Referral Hospital located in Southwest China.MethodsA retrospective analysis was conducted on 660 cases of bacterial keratitis occurring between January 2015 and December 2022. The demographic
-
The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-11 Shuxian Wang, Ren Fang, Hui Wang, Xiaotian Li, Jiayin Xing, Zhaoli Li, Ningning Song
Metal ions are essential trace elements for all living organisms and play critical catalytic, structural, and allosteric roles in many enzymes and transcription factors. Mycobacterium tuberculosis (MTB), as an intracellular pathogen, is usually found in host macrophages, where the bacterium can survive and replicate. One of the reasons why Tuberculosis (TB) is so difficult to eradicate is the continuous
-
Talaromycosis from Wuhan: two-case report and literature review Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-11 Zhiyuan Yao, Zhou Pan, Guang Li, Zhaomin Liao, Zhen Yu, Liying Zhan, Wenfang Xia
BackgroundTalaromycosis is a serious opportunistic infectious disease caused by Talaromyces marneffei, which mostly occurs in immunocompromised patients. The disease is mainly prevalent in tropical countries and regions of Southeast Asia and South Asia, but non-endemic areas also have patients with Talaromycosis. The disease has no characteristic clinical manifestations and is difficult to diagnose
-
Gallbladder microbial species and host bile acids biosynthesis linked to cholesterol gallstone comparing to pigment individuals Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-11 Xinpeng Zhang, Junqing Hu, Yi Li, Jichao Tang, Kaijin Yang, Ayan Zhong, Yanjun Liu, Tongtong Zhang
Gallstones are crystalline deposits in the gallbladder that are traditionally classified as cholesterol, pigment, or mixed stones based on their composition. Microbiota and host metabolism variances among the different types of gallstones remain largely unclear. Here, the bile and gallstone microbial species spectra of 29 subjects with gallstone disease (GSD, 24 cholesterol and 5 pigment) were revealed
-
Deciphering the role of female reproductive tract microbiome in reproductive health: a review Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-08 Hong Gao, Qiao Liu, Xiaolan Wang, Ting Li, Huanhuan Li, Genlin Li, Lingling Tan, Yahui Chen
Relevant studies increasingly indicate that female reproductive health is confronted with substantial challenges. Emerging research has revealed that the microbiome interacts with the anatomy, histology, and immunity of the female reproductive tract, which are the cornerstone of maintaining female reproductive health and preventing adverse pregnancy outcomes. Currently, the precise mechanisms underlying
-
The effect of vitamin D deficiency on platelet parameters in patients with COVID-19 Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-08 Amirhossein Talebzadeh, Hadi Ghaffari, Kazem Ghaffari, Sorur Yazdanpanah, Bahman Yousefi Goltappeh, Majid Eslami, Ali Ghasemi
IntroductionSince there is very little information about the relationship between platelet parameters and vitamin D concentration in patients with COVID-19, the aim of this study is to investigate the relationship between serum vitamin D level and platelet parameters in patients with COVID-19 and to compare these parameters in patients with COVID-19 without vitamin D deficiency and, subsequently, the
-
Characterization of a Straboviridae phage vB_AbaM-SHI and its inhibition effect on biofilms of Acinetobacter baumannii Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-08 Liming Jiang, Qian Xu, Ying Wu, Xianglian Zhou, Zhu Chen, Qiangming Sun, Jinsheng Wen
Acinetobacter baumannii (A. baumannii) is a popular clinical pathogen worldwide. Biofilm-associated antibiotic-resistant A. baumannii infection poses a great threat to human health. Bacteria in biofilms are highly resistant to antibiotics and disinfectants. Furthermore, inhibition or eradication of biofilms in husbandry, the food industry and clinics are almost impossible. Phages can move across the
-
Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-08 Qian Yang, Benhua Li, Tiankuo Luan, Xiaoyu Wang, Bixia Duan, Chengcheng Wei, Shi Chen
IntroductionSerological responses following hepatitis B vaccination are crucial for preventing hepatitis B (HBV). However, the potential relationship between serum lipid levels and immunity from HBV vaccination remains poorly understood.MethodsIn this study, we conducted an analysis of the National Health and Nutrition Examination Survey (NHANES) data spanning from 2003 to 2016. Multivariable weighted
-
A comparative study of genotyping and antimicrobial resistance between carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii isolates at a tertiary pediatric hospital in China Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-08 Xiaoli Jian, Yunyun Li, Haiping Wang, Cuilian Li, Feng Li, Jue Li, Jing Dong, Tingyi Du, Li Jiang
BackgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolations have rapidly increased in pediatric patients. To investigate a possible health care-associated infections of CRKP in a tertiary pediatric hospital, the circulating clones and carbapenem-resistant pattern between CRKP and carbapenem-resistant Acinetobacter baumannii (CRAB) isolates were compared to classify their epidemiological
-
Toxoplasma gondii infection-induced host cellular DNA damage is strain-dependent and leads to the activation of the ATM-dependent homologous recombination pathway Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-07 Lisbeth Rojas-Barón, Carlos Hermosilla, Anja Taubert, Zahady D. Velásquez
Toxoplasma gondii is a globally occurring apicomplexan parasite that infects humans and animals. Globally, different typical and atypical haplotypes of T. gondii induce varying pathologies in hosts. As an obligate intracellular protozoon, T. gondii was shown to interfere with host cell cycle progression, leading to mitotic spindle alteration, chromosome segregation errors and cytokinesis failure which
-
Construction and validation of a machine learning model for the diagnosis of juvenile idiopathic arthritis based on fecal microbiota Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-07 Jun-Bo Tu, Wei-Jie Liao, Si-Ping Long, Meng-Pan Li, Xing-Hua Gao
PurposeHuman gut microbiota has been shown to be significantly associated with various inflammatory diseases. Therefore, this study aimed to develop an excellent auxiliary tool for the diagnosis of juvenile idiopathic arthritis (JIA) based on fecal microbial biomarkers.MethodThe fecal metagenomic sequencing data associated with JIA were extracted from NCBI, and the sequencing data were transformed
-
Antibiotic resistance of ESKAPE group-microorganisms in health institutions from Hermosillo and Ciudad Obregón, Sonora, México Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-07 Maritza Lizeth Álvarez-Ainza, Pedro Alejandro Fong-Coronado, Eduardo Ruiz-Bustos, Lucía Guadalupe Castillón-Campaña, Idania Emedith Quintero-Reyes, Luis Armando Duarte-Zambrano, Enrique Bolado-Martínez
IntroductionEnterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. are microorganisms referred as the ESKAPE group pathogens. These microorganisms have generated great concern in health institutions around the world since most of them have resistance to multiple antibiotics and cause most infections associated with
-
Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí
Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P. aeruginosa counteracts complement attack by binding Factor H (FH), a complement regulator that inactivates C3b, preventing the formation of the C3-convertase and complement amplification on the
-
Isoprinosine as a foot-and-mouth disease vaccine adjuvant elicits robust host defense against viral infection through immunomodulation Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Hyeong Won Kim, Mi-Kyeong Ko, Seokwon Shin, So Hui Park, Jong-Hyeon Park, Su-Mi Kim, Min Ja Lee
BackgroundCommercial foot-and-mouth disease (FMD) vaccines have limitations, such as local side effects, periodic vaccinations, and weak host defenses. To overcome these limitations, we developed a novel FMD vaccine by combining an inactivated FMD viral antigen with the small molecule isoprinosine, which served as an adjuvant (immunomodulator).MethodWe evaluated the innate and adaptive immune responses
-
Evaluation of novel compounds as anti-bacterial or anti-virulence agents Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Brankica Filipić, Dušan Ušjak, Martina Hrast Rambaher, Slavica Oljacic, Marina T. Milenković
Antimicrobial resistance is a global threat, leading to an alarming increase in the prevalence of bacterial infections that can no longer be treated with available antibiotics. The World Health Organization estimates that by 2050 up to 10 million deaths per year could be associated with antimicrobial resistance, which would equal the annual number of cancer deaths worldwide. To overcome this emerging
-
Isolation and identification of Wickerhamiella tropicalis from blood culture by MALDI-MS Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Satomi Takei, Kanae Teramoto, Junya Fujimura, Megumi Fujiwara, Mai Suzuki, Yukiko Fukui, Yuji Sekiguchi, Takaaki Kawakami, Masayoshi Chonan, Mitsuru Wakita, Yuki Horiuchi, Takashi Miida, Toshio Naito, Teruo Kirikae, Tatsuya Tada, Yoko Tabe
Wickerhamiella is a genus of budding yeast that is mainly isolated from environmental samples, and 40 species have been detected. The yeast isolated from human clinical samples usually only contain three species: W. infanticola, W. pararugosa and W. sorbophila. In this study, we isolated W. tropicalis from a blood sample of a six-year-old female with a history of B-cell precursor lymphoblastic leukemia
-
Signatures of disease outcome severity in the intestinal fungal and bacterial microbiome of COVID-19 patients Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Fernando Rizzello, Elisa Viciani, Paolo Gionchetti, Eleonora Filippone, Veronica Imbesi, Laura Melotti, Nikolas Konstantine Dussias, Marco Salice, Barbara Santacroce, Antonella Padella, Alena Velichevskaya, Andrea Marcante, Andrea Castagnetti
BackgroundCOVID-19, whose causative pathogen is the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic in March 2020. The gastrointestinal tract is one of the targets of this virus, and mounting evidence suggests that gastrointestinal symptoms may contribute to disease severity. The gut–lung axis is involved in the immune response to SARS-CoV-2; therefore, we investigated
-
A comprehensive review of monkeypox virus and mpox characteristics Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Emmanuel Alakunle, Daniel Kolawole, Diana Diaz-Cánova, Faith Alele, Oyelola Adegboye, Ugo Moens, Malachy Ifeanyi Okeke
Monkeypox virus (MPXV) is the etiological agent of monkeypox (mpox), a zoonotic disease. MPXV is endemic in the forested regions of West and Central Africa, but the virus has recently spread globally, causing outbreaks in multiple non-endemic countries. In this paper, we review the characteristics of the virus, including its ecology, genomics, infection biology, and evolution. We estimate by phylogenomic
-
Unveiling the antibacterial mechanism of resveratrol against Aeromonas hydrophila through proteomics analysis Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Yuying Fu, Lishan Zhang, Yi Lin, Xinrui Zhao, Haoyu Chen, Yicheng Zhong, Wenjia Jiang, Xiaoyun Wu, Xiangmin Lin
This investigation delves into elucidating the mechanism by which resveratrol (Res), a natural polyterpenoid renowned for its antimicrobial properties, exerts its effects on Aeromonas hydrophila, a ubiquitous waterborne pathogen. Our findings underscore the dose-dependent manifestation of resveratrol in exhibiting antibacterial and antibiofilm formation activities against A. hydrophila. Employing a
-
Validating the inactivation of viral pathogens with a focus on SARS-CoV-2 to safely transfer samples from high-containment laboratories Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Sankar Prasad Chaki, Melissa M. Kahl-McDonagh, Benjamin W. Neuman, Kurt A. Zuelke
IntroductionPathogen leak from a high-containment laboratory seriously threatens human safety, animal welfare, and environmental security. Transportation of pathogens from a higher (BSL4 or BSL3) to a lower (BSL2) containment laboratory for downstream experimentation requires complete pathogen inactivation. Validation of pathogen inactivation is necessary to ensure safety during transportation. This
-
Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Dipak Kumar Sahoo, David Wong, Anil Patani, Biswaranjan Paital, Virendra Kumar Yadav, Ashish Patel, Albert E. Jergens
Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an imbalanced immune response to infection. Although an increased inflammatory response significantly contributes to the pathogenesis of sepsis, several molecular mechanisms underlying the progression of sepsis are associated with increased cellular reactive oxygen species (ROS) generation and exhausted antioxidant
-
The cutaneous beta human papillomavirus type 8 E6 protein induces CCL2 through the CEBPα/miR-203/p63 pathway to support an inflammatory microenvironment in epidermodysplasia verruciformis skin lesions Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Luca Vella, Anna Sternjakob, Stefan Lohse, Alina Fingerle, Tanya Sperling, Claudia Wickenhauser, Michael Stöckle, Thomas Vogt, Klaus Roemer, Monika Ołdak, Sigrun Smola
Human papillomavirus type 8 (HPV8), a cutaneous genus beta HPV type, has co-carcinogenic potential at sun-exposed sites in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). We had previously shown that Langerhans cells responsible for epithelial immunosurveillance were strongly reduced at infected sites and that the HPV8 E7 protein interferes with the CCAAT/enhancer-binding
-
PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Lavanya Mahadevan, Hemant Arya, Andrea Droste, Wolfgang Schliebs, Ralf Erdmann, Vishal C. Kalel
Trypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes. The heterohexameric AAA-ATPase complex of PEX1-PEX6 is anchored to the peroxisomal membrane and functions in the export of matrix protein import receptor PEX5 from the peroxisomal membrane. Defects in PEX1, PEX6 or their membrane anchor causes dysfunction
-
Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-06 Qianfei Wang, Tianci Gao, Weichao Zhang, Dong Liu, Xin Li, Fenqiao Chen, Jianqiang Mei
BackgroundChanges in the gut microbiota are closely related to insomnia, but the causal relationship between them is not yet clear.ObjectiveTo clarify the relationship between the gut microbiota and insomnia and provide genetic evidence for them, we conducted a two-sample Mendelian randomization study.MethodsWe used a Mendelian randomized two-way validation method to discuss the causal relationship
-
Association between gut microbiota and pan-dermatological diseases: a bidirectional Mendelian randomization research Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Yingwei Wang, Tao Yao, Yunlu Lin, Hongping Ge, Bixin Huang, Yu Gao, Jianming Wu
Background Gut microbiota has been associated with dermatological problems in earlier observational studies. However, it is unclear whether gut microbiota has a causal function in dermatological diseases. Methods Thirteen dermatological diseases were the subject of bidirectional Mendelian randomization (MR) research aimed at identifying potential causal links between gut microbiota and these diseases
-
Integrins regulation of wound healing processes: insights for chronic skin wound therapeutics Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Dong Yu, Zhaoyu Lu, Fengsong Nie, Yang Chong
Integrins are heterodimers composed of non-covalently associated alpha and beta subunits that mediate the dynamic linkage between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are present in various tissues and organs and are involved in different physiological and pathological molecular responses in vivo. Wound healing is an important process in the recovery
-
Diagnosis and management of invasive fungal diseases in non-neutropenic ICU patients, with focus on candidiasis and aspergillosis: a comprehensive review Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Afzal Azim, Armin Ahmed
Invasive fungal diseases pose a significant threat to non-neutropenic ICU patients, with Candida and Aspergillus infections being the most common. However, diagnosing these infections in the ICU population remains challenging due to overlapping clinical features, poor sensitivity of blood cultures, and invasive sampling requirements. The classical host criteria for defining invasive fungal disease
-
Subversion of a family of antimicrobial proteins by Salmonella enterica Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Roman G. Gerlach, Irene Wittmann, Lena Heinrich, Olaf Pinkenburg, Torben Meyer, Laura Elpers, Christiane Schmidt, Michael Hensel, Markus Schnare
Salmonella enterica is a food-borne pathogen able to cause a wide spectrum of diseases ranging from mild gastroenteritis to systemic infections. During almost all stages of the infection process Salmonella is likely to be exposed to a wide variety of host-derived antimicrobial peptides (AMPs). AMPs are important components of the innate immune response which integrate within the bacterial membrane
-
The impact of gut microbiota on autoimmune thyroiditis and relationship with pregnancy outcomes: a review Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Yu Song, Yu Bai, Cong Liu, Xiaodan Zhai, Le Zhang
Autoimmune thyroiditis (AITD) is a T-cell-mediated, organ- specific autoimmune disease caused by interactions between genetic and environmental factors. Patients with AITD show thyroid lymphocyte infiltration and an increase in the titer of thyroid autoimmune antibodies, thereby altering the integrity of thyroid follicle epithelial cells and dysregulating their metabolism and immune function, leading
-
Dynamic modulation of the non-canonical NF-κB signaling pathway for HIV shock and kill Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Aswath P. Chandrasekar, Mark Maynes, Andrew D. Badley
HIV cure still remains an elusive target. The “Shock and Kill” strategy which aims to reactivate HIV from latently infected cells and subsequently kill them through virally induced apoptosis or immune mediated clearance, is the subject of widespread investigation. NF-κB is a ubiquitous transcription factor which serves as a point of confluence for a number of intracellular signaling pathways and is
-
Genome and evolution of Tibet orbivirus, TIBOV (genus Orbivirus, family Reoviridae) Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Tingting Gao, Minghua Li, Hong Liu, Shihong Fu, Huanyu Wang, Guodong Liang
Tibet orbivirus (TIBOV) was first isolated from Anopheles maculatus mosquitoes in Xizang, China, in 2009. In recent years, more TIBOV strains have been isolated in several provinces across China, Japan, East Asia, and Nepal, South Asia. Furthermore, TIBOVs have also been isolated from Culex mosquitoes, and several midge species. Additionally, TIBOV neutralizing antibodies have been detected in serum
-
Ursodeoxycholic acid does not reduce SARS-CoV-2 infection in newly allogeneic hematopoietic stem cell transplantation recipients: a prospective NICHE cohort Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-05 Hongye Gao, Jiali Wang, Xinhui Zheng, Xiaolei Pei, Yawei Zheng, Weihua Zhai, Rongli Zhang, Xin Chen, Qiaoling Ma, Jialin Wei, Donglin Yang, Aiming Pang, Yi He, Sizhou Feng, Yigeng Cao, Erlie Jiang
IntroductionRetrospective studies have suggested that Ursodeoxycholic Acid (UDCA) provide a protective effect against SARS-CoV-2 infection, particularly in patients with liver disease. However, it is uncertain whether this finding can be extended to the allogeneic hematopoietic stem cell transplantation (allo-HSCT) cohort. Therefore, we aim to examine the protective potential of UDCA against SARS-CoV-2
-
Thrombocytopenia in Klebsiella pneumoniae liver abscess: a retrospective study on its correlation with disease severity and potential causes Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Lulu Chen, Hongguang Wang, Hairui Wang, Yawen Guo, Zhihui Chang
Objective Thrombocytopenia is commonly associated with infectious diseases and serves as an indicator of disease severity. However, reports on its manifestation in conjunction with Klebsiella pneumoniae liver abscess (KPLA) are scarce. The present study sought to elucidate the correlation between thrombocytopenia and KPLA severity and delve into the etiological factors contributing to the incidence
-
Detection and quantification of natural Wolbachia in Aedes aegypti in Metropolitan Manila, Philippines using locally designed primers Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Jerica Isabel L. Reyes, Takahiro Suzuki, Yasutsugu Suzuki, Kozo Watanabe
Background The Philippines bears health and economic burden caused by high dengue cases annually. Presently, the Philippines still lack an effective and sustainable vector management. The use of Wolbachia, a maternally transmitted bacterium, that mitigate arbovirus transmission has been recommended. Cytoplasmic incompatibility and viral blocking, two characteristics that make Wolbachia suitable for
-
Airway necrosis and granulation tissue formation caused by Rhizopus oryzae leading to severe upper airway obstruction: a case report Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Geng-Jia Chen, Xiao-Bo Chen, Wan-Yuan Rao, Xiao-Yi Pan, Shi-Yue Li, Zhu-Quan Su
Pulmonary Mucormycosis is a fatal infectious disease with high mortality rate. The occurrence of Mucormycosis is commonly related to the fungal virulence and the host’s immunological defenses against pathogens. Mucormycosis infection and granulation tissue formation occurred in the upper airway was rarely reported. This patient was a 60-year-old male with diabetes mellitus, who was admitted to hospital
-
Development and validation a nomogram prediction model for early diagnosis of bloodstream infections in the intensive care unit Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Zhili Qi, Lei Dong, Jin Lin, Meili Duan
PurposeThis study aims to develop and validate a nomogram for predicting the risk of bloodstream infections (BSI) in critically ill patients based on their admission status to the Intensive Care Unit (ICU).Patients and methodsPatients’ data were extracted from the Medical Information Mart for Intensive Care−IV (MIMIC−IV) database (training set), the Beijing Friendship Hospital (BFH) database (validation
-
Detection of infectious SARS-CoV-2 in ocular samples is linked to viral load in the nasopharynx Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Janine Kimpel, Annika Rössler, David Bante, Wegene Borena, Dorothee von Laer, Claus Zehetner, Teresa Rauchegger, Stefanie Seiwald, Barbara Falkensammer
IntroductionSARS-CoV-2 is known to infect respiratory tissue cells. However, less is known about infection of ocular tissue and potential infectivity of lacrimal fluid. With this study, we want to compare viral loads in eye and nasopharyngeal swabs and analyze these for infectious virus.MethodsBetween May 2020 and April 2021 ocular and nasopharyngeal swabs were collected from 28 SARS-CoV-2 infected
-
Influenza and COVID-19 co-infection and vaccine effectiveness against severe cases: a mathematical modeling study Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Jingyi Liang, Yangqianxi Wang, Zhijie Lin, Wei He, Jiaxi Sun, Qianyin Li, Mingyi Zhang, Zichen Chang, Yinqiu Guo, Wenting Zeng, Tie Liu, Zhiqi Zeng, Zifeng Yang, Chitin Hon
BackgroundInfluenza A virus have a distinctive ability to exacerbate SARS-CoV-2 infection proven by in vitro studies. Furthermore, clinical evidence suggests that co-infection with COVID-19 and influenza not only increases mortality but also prolongs the hospitalization of patients. COVID-19 is in a small-scale recurrent epidemic, increasing the likelihood of co-epidemic with seasonal influenza. The
-
Phage P2-71 against multi-drug resistant Proteus mirabilis: isolation, characterization, and non-antibiotic antimicrobial potential Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Zhiyou Dong, Ruihu Wu, Lijuan Liu, Shengquan Ai, Jinpeng Yang, Qianlan Li, Keyi Fu, Yunian Zhou, Hualin Fu, Ziyao Zhou, Haifeng Liu, Zhijun Zhong, Xianmeng Qiu, Guangneng Peng
Proteus mirabilis, a prevalent urinary tract pathogen and formidable biofilm producer, especially in Catheter-Associated Urinary Tract Infection, has seen a worrying rise in multidrug-resistant (MDR) strains. This upsurge calls for innovative approaches in infection control, beyond traditional antibiotics. Our research introduces bacteriophage (phage) therapy as a novel non-antibiotic strategy to combat
-
Bumble bee microbiota shows temporal succession and increase of lactic acid bacteria when exposed to outdoor environments Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Arne Weinhold, Elisabeth Grüner, Alexander Keller
QuestionThe large earth bumble bee (Bombus terrestris) maintains a social core gut-microbiota, similar as known from the honey bee, which plays an important role for host health and resistance. Experiments under laboratory conditions with commercial hives are limited to vertically transmitted microbes and neglect influences of environmental factors or external acquisition of microbes. Various environmental
-
Identifying potential monkeypox virus inhibitors: an in silico study targeting the A42R protein Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Carolyn N. Ashley, Emmanuel Broni, Chanyah M. Wood, Tunmise Okuneye, Mary-Pearl T. Ojukwu, Qunfeng Dong, Carla Gallagher, Whelton A. Miller
Monkeypox (now Mpox), a zoonotic disease caused by the monkeypox virus (MPXV) is an emerging threat to global health. In the time span of only six months, from May to October 2022, the number of MPXV cases breached 80,000 and many of the outbreaks occurred in locations that had never previously reported MPXV. Currently there are no FDA-approved MPXV-specific vaccines or treatments, therefore, finding
-
Functional characterization of Francisella tularensis subspecies holarctica genotypes during tick cell and macrophage infections using a proteogenomic approach Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Sara Doina Schütz, Maximilian Brackmann, Nicole Liechti, Michel Moser, Matthias Wittwer, Rémy Bruggmann
Tularemia is a vector-borne disease caused by the Gram-negative bacterium Francisella tularensis. Known hosts and vectors in Europe are hare and ticks. F. tularensis is transmitted from ticks and animals, but also from the hydrotelluric environment and the consumption of contaminated water or food. A changing climate expands the range in which ticks can live and consequently might contribute to increasing
-
Optimal selection of specimens for metagenomic next-generation sequencing in diagnosing periprosthetic joint infections Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-04 Jun Tan, Lingxiao Wu, Lijuan Zhan, Minkui Sheng, Zhongxin Tang, Jianzhong Xu, Haijun Ma
ObjectiveThis study aimed to assess the diagnostic value of metagenomic next-generation sequencing (mNGS) across synovial fluid, prosthetic sonicate fluid, and periprosthetic tissues among patients with periprosthetic joint infection (PJI), intending to optimize specimen selection for mNGS in these patients.MethodsThis prospective study involved 61 patients undergoing revision arthroplasty between
-
The role of sialidases in the pathogenesis of bacterial vaginosis and their use as a promising pharmacological target in bacterial vaginosis Front. Cell. Infect. Microbiol. (IF 5.7) Pub Date : 2024-03-01 Liuyan Chen, Jiayue Li, Bingbing Xiao
Bacterial vaginosis (BV) is an infection of the genital tract characterized by disturbance of the normally Lactobacilli-dominated vaginal flora due to the overgrowth of Gardnerella and other anaerobic bacteria. Gardnerella vaginalis, an anaerobic pathogen and the major pathogen of BV, produces sialidases that cleave terminal sialic acid residues off of human glycans. By desialylation, sialidases not