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The Protective Effect of Anthocyanins Extracted from Aronia Melanocarpa Berry in Renal Ischemia-Reperfusion Injury in Mice Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-22 Li Li; Jun Li; Hui Xu; Fengmei Zhu; Zhijun Li; Hongzhi Lu; Jinrong Zhang; Zhengsheng Yang; Yongsheng Liu
Background. Our previous research showed the antioxidant activity of anthocyanins extracted from Aronia melanocarpa of black chokeberry in vitro. Ischemia acute kidney injury is a significant risk in developing progressive and deterioration of renal function leading to clinic chronic kidney disease. There were many attempts to protect the kidney against this progression of renal damage. Current study
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Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves’ Ophthalmopathy through the Regulation of FoxO3a Signaling Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-21 Yi-Hsuan Wei; Shu-Lang Liao; Chia-Chun Wang; Sen-Hsu Wang; Wan-Chun Tang; Chang-Hao Yang
Graves’ ophthalmopathy (GO), which is characterized by orbital tissue inflammation, expansion, and fibrosis, is the ocular manifestation in 25% to 50% of patients with Graves’ disease. As the pathology of GO is driven by autoimmune inflammation, many proinflammatory cytokines/chemokines, including TNF-α, IL-1β, IL-6, and CCL20, are crucial in the pathogenesis of GO to activate the orbital fibroblasts
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Yeast Fermentate Prebiotic Ameliorates Allergic Asthma, Associating with Inhibiting Inflammation and Reducing Oxidative Stress Level through Suppressing Autophagy Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-20 Subo Gong; Xiaoying Ji; Jing Su; Yina Wang; Xianghong Yan; Guyi Wang; Bin Xiao; Haiyun Dong; Xudong Xiang; Shaokun Liu
Background and Purpose. Allergic asthma, a respiratory disease with high morbidity and mortality, is reported to be related to the airway allergic inflammation and autophagy-induced oxidative stress. Although the therapeutic effects of fermentate prebiotic (YFP) on allergic asthma have been widely claimed, the underlying mechanism is still unclear. This study is aimed at investigating the possible
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6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-19 Mohammed A. Alsahli; Saleh A. Almatroodi; Ahmad Almatroudi; Amjad Ali Khan; Shehwaz Anwar; Abdulmajeed G. Almutary; Faris Alrumaihi; Arshad Husain Rahmani
Diethylnitrosamine (DEN) is a well-known hepatocarcinogen, and its oral administration causes severe liver damage including cancer. DEN induces the pathogenesis of the liver through reactive oxygen species mediated inflammation and modulation of various biological activities. 6-Gingerol, a major component of ginger, is reported to prevent liver diseases by reducing the oxidative stress and proinflammatory
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Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-18 Katharina Ritter; Kirsten Jung; Christopher Dolderer; Dominik Appel; Christine C. Oswald; Ulrike Ritz; Michael K. E. Schäfer
Traumatic brain injury (TBI) represents a major cause of death and disability in early adulthood. Concomitant extracranial injury such as long bone fracture was reported to exacerbate TBI pathology. However, early reciprocal effects and mechanisms have been barely investigated. To address this issue, C57BL/6N mice were subjected to either the controlled cortical impact (CCI) model of TBI, fracture
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Factors Related to Bone Metabolism in Kidney Transplant Recipients Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-16 Chenxiu Wang; Yanan Huo; Xinchang Li; Anhua Lin; Qingxiang Hu; Changhui Xiong; Ying Deng
This study is aimed at establishing the prevalence of osteoporosis and osteopenia in kidney transplant recipients (KTRs) and determining the risk factors for bone mass loss. We invited KTRs who were under regular follow-up at Jiangxi Provincial People’s Hospital Affiliated with Nanchang University to attend an assessment of osteoporotic risk assessed by questionnaire, biochemical profile, and dual-energy
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COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-15 Mohamed M. Aboudounya; Richard J. Heads
Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammatory cytokines to combat infection. It is expressed on both immune cells and tissue-resident
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Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-15 Ivan Wudexi; Elica Shokri; Mohamed Abo-Aly; Kazuhiro Shindo; Ahmed Abdel-Latif
Introduction and Hypothesis. The role of inflammation is widely recognized in the pathogenesis of coronary artery disease. Research on animal models had shown the potential benefits of targeting specific inflammatory pathways. However, studies on human subjects are limited with small number of patients and no head-to-head comparisons. Methods. We conducted a network meta-analysis of randomized controlled
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Activation of Opioid Receptors Attenuates Ischemia/Reperfusion Injury in Skeletal Muscle Induced by Tourniquet Placement Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-15 Yue-Xian Guo; Gui-Ying Wang; Wen-jie Cheng; Cai-Zhen Yan; Shuang Zhao; Zhao Li; Peng Liu; Xiu-Li Wang
Background and Objectives. Tourniquet-induced ischemia/reperfusion (I/R) injury is a common clinical problem for patients receiving surgery. The objective of this study is to determine if oxycodone (Oxy) reduces skeletal muscle I/R damage induced by tourniquet placement and explores the underlying mechanisms. Method. Mice were randomly assigned to the sham, I/R, Oxy, and I/R with Oxy groups. Oxy was
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The Relationship between Retinol-Binding Protein 4 and Markers of Inflammation and Thrombogenesis in Children with Kawasaki Disease Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-11 Maoling Yang; Haobo Weng; Qiongfei Pei; Fengchuan Jing; Qijian Yi
Background. Kawasaki disease (KD) is a self-limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications. Retinol-binding protein 4 (RBP4) has been confirmed effects on vasodilation, platelet activation inhibition, and cardiovascular diseases by researches. Therefore, this study was aimed at investigating the relationship between RBP4
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Elevation of Inflammatory Cytokines and Proteins after Intra-Articular Ankle Fracture: A Cross-Sectional Study of 47 Ankle Fracture Patients Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-09 That Minh Pham; Lars Henrik Frich; Kate Lykke Lambertsen; Søren Overgaard; Hagen Schmal
Introduction. Intra-articular fractures are the leading etiology for posttraumatic osteoarthritis (PTOA) in the ankle. Elevation of proinflammatory cytokines following intra-articular fracture may lead to synovial catabolism and cartilage degradation. We aimed to compare cytokine levels in injured and healthy ankle joints, examine the longer-term cytokine levels in fractured ankles, and investigate
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MicroRNA-155: Regulation of Immune Cells in Sepsis Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-08 Ming Chen; Fuquan Wang; Haifa Xia; Shanglong Yao
MicroRNAs are small noncoding RNAs which regulate gene expression at the posttranscriptional level. miR-155 is encoded by the miR-155 host gene (miR155HG), also known as the noncoding B cell integration cluster (BIC). MicroRNAs are widely expressed in various hematopoietic cells and are involved in regulating the immune system. In this review, we summarized how miR-155 modulates specific immune cells
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Effect of Oral Administration with Lactobacillus plantarum CAM6 Strain on Sows during Gestation-Lactation and the Derived Impact on Their Progeny Performance Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-08 César Betancur; Yordan Martínez; Guillermo Tellez-Isaias; Rogel Castillo; Xinghua Ding
Background. To evaluate the biological response of the sows and their offspring with oral administration of Lactobacillus plantarum CAM6 in breeding sows, a total of 20 Pietrain breeding sows with three farrowings and their descendants were used, randomly divided into two groups of 10 sows each. Treatments included a basal diet (T0) and basal diet +10 mL biological agent containing 109 CFU/mL L. plantarum
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Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-07 Seidu A. Richard
Licorice extract is a Chinese herbal medication most often used as a demulcent or elixir. The extract usually consists of many components but the key ingredients are glycyrrhizic (GL) and glycyrrhetinic acid (GA). GL and GA function as potent antioxidants, anti-inflammatory, antiviral, antitumor agents, and immuneregulators. GL and GA have potent activities against hepatitis A, B, and C viruses, human
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circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-07 Jie Zhu; Yong Zhou; Shanshan Zhu; Fei Li; Jiajia Xu; Liming Zhang; Hairong Shu
Emerging evidence has shown that circular RNAs (circRNAs) and DNA methylation play important roles in the causation and progression of cancers. However, the roles of circRNAs and abnormal methylation genes in the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) are still largely unknown. Expression profiles of circRNA, gene methylation, and mRNA were downloaded from the GEO database, and differentially
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lncRNA SNHG14 Plays a Role in Sepsis-Induced Acute Kidney Injury by Regulating miR-93 Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-06 Chuanchuan Shi; Yuqian Zhao; Qi Li; Jianguo Li
Acute kidney injury (AKI) is a common organ injury in sepsis, which leads to poor prognosis. Long noncoding RNA (lncRNA) small nucleolus RNA host gene 14 (SNHG14) was recognized to induce cell injury in LPS-induced acute lung injury and Parkinson’s disease. We want to investigate the functions and mechanisms of SNHG14 in sepsis-induced AKI. Increased expression of SNHG14 was observed in LPS-induced
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Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-06 Janka Franeková; Marek Protuš; Eva Kieslichová; Aleš Březina; Jitka Komrsková; Jiří Vymětalík; Antonín Jabor
Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed
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The Effect of Lipid Metabolism on CD4+ T Cells Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-06 Feiyang Cai; Shuxin Jin; Guangjie Chen
CD4+ T cells play a vital role in the adaptive immune system and are involved in the pathogenesis of many diseases, including cancer, autoimmune diseases, and chronic inflammation. As an important mechanism for energy storage, a lot of researches have clarified that metabolism imbalance interacts with immune disorder, and one leads to the other. Lipid metabolism has close relationship with CD4+ T cells
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MMP-9 Concentration in Peritoneal Fluid Is a Valuable Biomarker Associated with Endotoxemia in Equine Colic Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-05 Ann Kristin Barton; Ina-Gabriele Richter; Tanja Ahrens; Roswitha Merle; Abdollah Alalwani; Svenja Lilge; Katrin Purschke; Dirk Barnewitz; Heidrun Gehlen
The purpose of the study was to compare the results of sepsis scoring (clinical examination and clinical pathology) to the concentrations of matrix-metalloproteinases (MMPs) -2, -8, and -9; tissue-inhibitor of metalloproteinases (TIMPs) -1 and -2; and inflammatory chemokines interleukin (IL) 1β and tumor-necrosis-factor-alpha (TNF-α) in plasma and peritoneal fluid of equine colic patients. A modified
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The Role of CARD9 Deficiency in Neutrophils Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-05 Ruanmei Sheng; Xiaoming Zhong; Zhiwen Yang; Xuemin Wang
Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular
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Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity Mediat. Inflamm. (IF 3.758) Pub Date : 2021-01-04 Yawei Fu; Yadong Wang; Hu Gao; DongHua Li; RuiRui Jiang; Lingrui Ge; Chao Tong; Kang Xu
Omega-3 polyunsaturated fatty acids (omega-3 PUFAs), which are essential fatty acids that humans should obtain from diet, have potential benefits for human health. In addition to altering the structure and function of cell membranes, omega-3 PUFAs (docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), and docosapentaenoic acid (DPA)) exert different effects on intestinal
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A Metabolic Gene Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-30 Zeng-Hong Wu; Yun Tang; Yue Zhou
Background. Head and neck squamous cell carcinoma (HNSCC) is a common malignancy that emanates from the lips, mouth, paranasal sinuses, oropharynx, larynx, nasopharynx, and from other pharyngeal cancers. The availability of high-throughput expression data has made it possible to use global gene expression data to analyze the relationship between metabolic-related gene expression and clinical outcomes
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VGLL4 Protects against Oxidized-LDL-Induced Endothelial Cell Dysfunction and Inflammation by Activating Hippo-YAP/TEAD1 Signaling Pathway Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-30 Kaicheng Xu; Haomin Zhao; Xiaolei Qiu; Xiwen Liu; Fucheng Zhao; Yue Zhao
Vestigial-like 4 (VGLL4) has been found to have multiple functions in tumor development; however, its role in cardiovascular disease is unknown. The aim of this study was to investigate the effect of VGLL4 on the dysfunction and inflammatory response of Ox-LDL-induced human umbilical vein endothelial cells (HUVECs) and its mechanism, so as to provide a new theoretical basis for the diagnosis and treatment
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Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-30 Mingjun Du; Lei Yang; Jianmin Gu; Jiawei Wu; Yiwen Ma; Tao Wang
Ischemia reperfusion (IR) can lead to acute kidney injury and can be complicated by acute lung injury, which is one of the leading causes of acute kidney injury-related death. Peptidyl arginine deiminase-4 (PAD4) is a member of the PAD enzyme family and plays a critical role in inflammatory reactions and neutrophil extracellular trap formation in a variety of pathological conditions. It has been reported
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The Monocyte-to-Lymphocyte Ratio at Hospital Admission Is a Novel Predictor for Acute Traumatic Intraparenchymal Hemorrhage Expansion after Cerebral Contusion Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-29 Jiangtao Sheng; Tian Li; Dongzhou Zhuang; Shirong Cai; Jinhua Yang; Faxiu Ding; Xiaoxuan Chen; Fei Tian; Mindong Huang; Lianjie Li; Kangsheng Li; Weiqiang Chen
Purpose. To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (baseline) and follow-up computed tomography for volumetric analysis (retrospective
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Oxidative and/or Inflammatory Thrust Induced by Silver Nanoparticles in Rabbits: Effect of Vitamin E or NSAID Administration on Semen Parameters Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-28 Collodel Giulia; Mattioli Simona; Moretti Elena; Cerretani Daniela; Micheli Lucia; Fiaschi Anna Ida; Menchetti Laura; Brecchia Gabriele; Castellini Cesare
The aim of this research was to evaluate the inflammatory and/or oxidative damage related to silver nanoparticles (AgNPs), which are responsible for negative effects on sperm physiology and metabolism. Thirty New Zealand White rabbit bucks were divided into 5 experimental groups (6 animals/group): Control, treated with 0.9% NaCl; AgNP, treated with a 5 mM AgNP solution; LPS, treated with 50 g/kg b
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Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-28 Liwen Chen; Shuwang Liu; Wei Xu; Yuan Zhang; Jin Bai; Lei Li; Ming Cui; Lijie Sun
Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia characterized by atrial remodeling. Complement C1q tumor necrosis factor-related protein 3 (CTRP3) is one of the adipokines associated with obesity, diabetes, and coronary heart disease. The association between plasma CTRP3 levels and AF is uncertain. The aim of this study was to investigate whether plasma CTRP3 concentrations were correlated
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Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-24 Kangyu Huang; Min Dai; Qiuli Li; Nannan Liu; Dainan Lin; Qiang Wang; Xuan Zhou; Zhixiang Wang; Ya Gao; Hua Jin; Xiaoli Liu; Qifa Liu; Hongsheng Zhou
Background. Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). However, the reports regarding risk factors of induction-related infection are roughly unknown/limited in adult T-ALL during induction chemotherapy. Methods. We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive
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Beneficial Effects of Rosmarinic Acid on IPEC-J2 Cells Exposed to the Combination of Deoxynivalenol and T-2 Toxin Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-22 Judit Mercédesz Pomothy; Réka Fanni Barna; Erzsébet Anna Pászti; Ákos Babiczky; Áron Szóládi; Ákos Jerzsele; Erzsébet Pásztiné Gere
Mycotoxin contamination in feedstuffs is a worldwide problem that causes serious health issues both in humans and animals, and it contributes to serious economic losses. Deoxynivalenol (DON) and T-2 toxin (T-2) are major trichothecene mycotoxins and are known to challenge mainly intestinal barrier functions. Polyphenolic rosmarinic acid (RA) appeared to have antioxidant and anti-inflammatory properties
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Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-22 Jian Lin; Gengfeng Li; Chunjin Xu; Huiying Lu; Cui Zhang; Zhi Pang; Zhanju Liu
Monocyte chemotactic protein 1-induced protein 1 (MCPIP-1) is highly expressed in activated immune cells and plays an important role in negatively regulating immune responses. However, its role in regulating neutrophil functions in the pathogenesis of inflammatory bowel disease (IBD) is still unclear. Here, we found that MCPIP-1 was markedly increased at both the transcriptional and translational levels
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C1q/TNF-Related Protein 9 Inhibits Coxsackievirus B3-Induced Injury in Cardiomyocytes through NF-κB and TGF-β1/Smad2/3 by Modulating THBS1 Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-21 Kebei Liu; Juan Wang; Xinru Gao; Wei Ren
C1q/TNF-related protein 9 (CTRP9) is implicated in diverse cardiovascular diseases, but its role in viral myocarditis (VMC) is not well explored. This study is aimed at investigating the role and potential mechanism of CTRP9 in VMC. Herein, we found that the peripheral blood collected from children with VMC had lower CTRP9 levels than that from children who had recovered from VMC. H9c2 cardiomyocytes
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Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-18 Yu Du; Yufei Song; Xiaojie Zhang; Yan Luo; Wenying Zou; Jiawei Zhang; Jianliang Fu
Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenesis of CCH-induced WMLs remains unknown. Therefore, we performed bilateral common carotid
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Therapeutic Effect of Ginsenoside Rd on Experimental Autoimmune Encephalomyelitis Model Mice: Regulation of Inflammation and Treg/Th17 Cell Balance Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-18 Bo Jin; Chixiao Zhang; Yu Geng; Mei Liu
Multiple sclerosis (MS) is an autoimmune inflammatory disease. Inflammatory infiltrates and demyelination of the CNS are the major characteristics of MS and its related animal model-experimental autoimmune encephalomyelitis (EAE). Immoderate autoimmune responses of Th17 cells and dysfunction of Treg cells critically contribute to the pathogenesis of MS and EAE. Our previous study showed that Ginsenoside
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Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-14 Thalia Jimenez; Theodore Friedman; Jaydutt Vadgama; Vineeta Singh; Alexandria Tucker; Javier Collazo; Satyesh Sinha; Amiya Sinha Hikim; Rajan Singh; Shehla Pervin
Breast cancer results from a complex interplay of genetics and environment that alters immune and inflammatory systems to promote tumorigenesis. Obesity and cigarette smoking are well-known risk factors associated breast cancer development. Nicotine known to decrease inflammatory signals also modulates immune responses that favor breast cancer development. However, the mechanisms by which nicotine
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Detection of CD39 and a Highly Glycosylated Isoform of Soluble CD73 in the Plasma of Patients with Cervical Cancer: Correlation with Disease Progression Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-07 Ricardo Muñóz-Godínez; María de Lourdes Mora-García; Benny Weiss-Steider; Juan José Montesinos-Montesinos; Adriana del Carmen Aguilar-Lemarroy; Rosario García-Rocha; Jorge Hernández-Montes; Christian Azucena Don-López; Luis Roberto Ávila-Ibarra; Daniela Berenice Torres-Pineda; Gabriela Molina-Castillo; Rommel Chacón-Salinas; Luis Vallejo-Castillo; Sonia Mayra Pérez-Tapia; Alberto Monroy-García
Persistent infection with high-risk human papillomavirus (HR-HPV) is the main factor in the development of cervical cancer (CC). The presence of immunosuppressive factors plays an important role in the development of this type of cancer. To determine whether CD39 and CD73, which participate in the production of immunosuppressive adenosine (Ado), are involved in the progression of CC, we compared the
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Corrigendum to “Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3K/Akt Pathway” Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-07 Bo Gui; Fuzhou Hua; Jie Chen; Zeping Xu; Hongbin Sun; Yanning Qian
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Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1β Inflammasome-Dependent Secretion Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-07 Pedro Henrique Bürgel; Clara Luna Marina; Pedro H. V. Saavedra; Patrícia Albuquerque; Stephan Alberto Machado de Oliveira; Paulo Henrique de Holanda Veloso Janior; Raffael Araújo de Castro; Heino M. Heyman; Carolina Coelho; Radames J. B. Cordero; Arturo Casadevall; Joshua D. Nosanchuk; Ernesto S. Nakayasu; Robin C. May; Aldo Henrique Tavares; Anamelia Lorenzetti Bocca
Cryptococcus neoformans is an encapsulated yeast that causes disease mainly in immunosuppressed hosts. It is considered a facultative intracellular pathogen because of its capacity to survive and replicate inside phagocytes, especially macrophages. This ability is heavily dependent on various virulence factors, particularly the glucuronoxylomannan (GXM) component of the polysaccharide capsule. Inflammasome
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COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-04 Leandro Borges; Tania Cristina Pithon-Curi; Rui Curi; Elaine Hatanaka
Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. Neutrophils play a critical function in the clearance of bacteria with specific mechanisms to combat viruses. The aim of this review is to highlight the
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Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-04 Li Zhang; El-Mustapha Haddouti; Hannes Beckert; Ralf Biehl; Shyam Pariyar; Julian M. Rüwald; Xian Li; Max Jaenisch; Christof Burger; Dieter C. Wirtz; Koroush Kabir; Frank A. Schildberg
Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their potential contribution to aseptic implant loosening. This study is aimed at examining
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Helminthostachys zeylanica Water Extract Ameliorates Airway Hyperresponsiveness and Eosinophil Infiltration by Reducing Oxidative Stress and Th2 Cytokine Production in a Mouse Asthma Model Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-02 Wen-Chung Huang; Nai-Chun Ting; Yu-Ling Huang; Li-Chen Chen; Chwan-Fwu Lin; Chian-Jiun Liou
Helminthostachys zeylanica is a traditional folk herb used to improve inflammation and fever in Taiwan. Previous studies showed that H. zeylanica extract could ameliorate lipopolysaccharide-induced acute lung injury in mice. The aim of this study was to investigate whether H. zeylanica water (HZW) and ethyl acetate (HZE) extracts suppressed eosinophil infiltration and airway hyperresponsiveness (AHR)
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Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients Mediat. Inflamm. (IF 3.758) Pub Date : 2020-12-03 Dariusz Kotlega; Agnieszka Zembron-Lacny; Barbara Morawin; Monika Golab-Janowska; Przemyslaw Nowacki; Malgorzata Szczuko
Objective. The neurotrophin brain-derived neurotrophic factor (BDNF) affects poststroke functional outcome, neurogenesis, neuroprotection, and neuroplasticity. Its level is related to the diet and nutritional status, and more specifically, it is free fatty acids (FFAs) and eicosanoids that can have an impact on the BDNF level. The aim of this study was to analyze the potential impact of FFAs and eicosanoids
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High-Fructose Diet Increases Inflammatory Cytokines and Alters Gut Microbiota Composition in Rats Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-30 Yong Wang; Wentao Qi; Ge Song; Shaojie Pang; Zhenzhen Peng; Yong Li; Panli Wang
High-fructose diet induced changes in gut microbiota structure and function, which have been linked to inflammatory response. However, the effect of small or appropriate doses of fructose on gut microbiota and inflammatory cytokines is not fully understood. Hence, the abundance changes of gut microbiota in fructose-treated Sprague-Dawley rats were analyzed by 16S rRNA sequencing. The effects of fructose
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Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-κB Pathway Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-29 Zige Liu; Yan Li; Fengying Guo; Chen Zhang; Guorui Song; Jiahao Yang; Desheng Chen
Peri-implant osteolysis (PIO) and the subsequent aseptic loosening are the main reasons for artificial joint implant failure. Existing methods for treating aseptic loosening are far from satisfactory, necessitating advanced drug exploration. This study is aimed at investigating the effect and underlying mechanism of tetrandrine (Tet) on inflammatory osteolysis. We established a Ti particle-induced
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-28 Jingjin Li; Chonglong Shi; Zhengnian Ding; Wenjie Jin
Postoperative cognitive dysfunction (POCD) is a common postoperative central nervous system complication, especially in the elderly. It has been consistently reported that the pathological process of this clinical syndrome is related to neuroinflammation and microglial proliferation. Glycogen synthase kinase 3β (GSK-3β) is a widely expressed kinase with distinct functions in different types of cells
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Effects of Dietary Histidine on Growth Performance, Serum Amino Acids, and Intestinal Morphology and Microbiota Communities in Low Protein Diet-Fed Piglets Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-28 Meng Kang; Jie Yin; Jie Ma; Xin Wu; Ke Huang; Tiejun Li; Long Ouyang
Previous study showed that low protein diet-fed pigs are characterized by lower histidine concentration in the serum and muscle, suggesting that histidine may involve in protein-restricted response. Thus, the current study mainly investigated the effects of dietary histidine on growth performance, blood biochemical parameters and amino acids, intestinal morphology, and microbiota communities in low
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Neutrophil-Lymphocyte Ratio in Predicting Infective Endocarditis: A Case-Control Retrospective Study Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-28 Ying Chen; Liang-jun Ye; Yue Wu; Bing-zheng Shen; Fan Zhang; Qiang Qu; Jian Qu
Background. Infective endocarditis (IE) is a complex infectious disease with high morbidity and mortality. The inflammation mechanism of IE is a complex network including interactions of inflammatory cytokines and other components of host response. As an important inflammation marker, the prediction ability of neutrophil-to-lymphocyte ratio (NLR) in IE deserves further investigation. Methods. NLR values
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Atopic Dermatitis and Psoriasis as Overlapping Syndromes Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-28 A. Bozek; M. Zajac; M. Krupka
Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational
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IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-28 Fernando Botelho; Anisha Dubey; Ehab A. Ayaub; Rex Park; Ashley Yip; Allison Humbles; Roland Kolbeck; Carl D. Richards
The interleukin-1 family member IL-33 participates in both innate and adaptive T helper-2 immune cell responses in models of lung disease. The IL-6-type cytokine Oncostatin M (OSM) elevates lung inflammation, Th2-skewed cytokines, alternatively activated (M2) macrophages, and eosinophils in C57Bl/6 mice in vivo. Since OSM induces IL-33 expression, we here test the IL-33 function in OSM-mediated lung
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Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-26 Maria Martinez-Urbistondo; Alberto Mora-Vargas; Esther Expósito-Palomo; Raquel Castejón; M. Jesús Citores; Silvia Rosado; Carmen de Mendoza; Isolina Baños; Ana Fernández-Cruz; Lidia Daimiel; Rodrigo San-Cristóbal; Juan Antonio Vargas; J. Alfredo Martinez
Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications
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High Erythropoiesis Resistance Index Is a Significant Predictor of Cardiovascular and All-Cause Mortality in Chinese Maintenance Hemodialysis Patients Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-26 Xiangxue Lu; Jialing Zhang; Shixiang Wang; Qian Yu; Han Li
Background. Renal anemia is a common complication of hemodialysis patients. Erythropoietin (EPO) hyporesponsiveness has been recognized as an important factor to poor efficacy of recombinant human erythropoietin in the treatment of renal anemia. More importantly, increased erythropoiesis resistance index (ERI) may be associated with inflammation and increased mortality. Objective. The objective of
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Total Glucosides of Paeony Alleviate Cell Apoptosis and Inflammation by Targeting the Long Noncoding RNA XIST/MicroRNA-124-3p/ITGB1 Axis in Renal Ischemia/Reperfusion Injury Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-25 Fang Chen; Yi Hu; Yuetao Xie; Zonghui Zhao; Lin Ma; Zhili Li; Wanlong Tan
Objective. Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods. Rat RI/RI models were constructed by surgical operation. Serum creatinine (Scr) and blood urea nitrogen (BUN) were used to evaluate
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Inflammatory Response, a Key Pathophysiological Mechanism of Obesity-Induced Depression Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-24 Shu-Lin Shao; Da-Qian Liu; Bo Zhang; Shu-Ming Huang
In recent years, with the acceleration of life rhythm and the increase of social competition, the incidence of obesity and depression has been increasing, which has seriously affected the quality of life and health of people. Obesity and depression, two seemingly unrelated physical and psychological diseases, in fact, are closely related: obese people are more likely to have depression than nonobese
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P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-24 Mariana Torrente Gonçalves; Carla Cristina Squaiella-Baptistão; Giselle Pidde; Priscila Hess Lopes; Iseu da Silva Nunes; Denise V. Tambourgi
P-MAPA is a complex compound, derived from Aspergillus oryzae cultures, that has shown immunomodulatory properties in infection and cancer animal models. Despite promising results in these models, the mechanisms of cellular activation by P-MAPA, suggested to be Toll-like receptor- (TLR-) dependent, and its effect on human immune cells, remain unclear. Using an ex vivo model of human whole blood, the
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Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3K/Akt-Bax/Bcl-2 Pathway Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-24 Chenye Wang; Caifei Ding; Zhoujia Hua; Chunyue Chen; Jia Yu
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder prevalent in females of reproductive age; insulin resistance (IR) is the major pathogenic driver. Pharmacology is a basic option for PCOS therapy; traditional Chinese medicine (TCM), as a significant part of complementary and alternative medicine, has a long history in the clinical management of PCOS. Cangfudaotan
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Lipoxin A4 Reduces Ventilator-Induced Lung Injury in Rats with Large-Volume Mechanical Ventilation Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-23 Qi Wang; Guang-xiao Xu; Qi-hang Tai; Yan Wang
Ventilator-induced lung injury (VILI) is a severe and inevitable complication in patients who require mechanical ventilation (MV) for respiratory support. Lipoxin A4 is an endogenous anti-inflammatory and antioxidant mediator. The present study determined the effects of lipoxin A4 on VILI. Twenty-four rats were randomized to the sham, VILI, and lipoxin A4 (LX4) groups. The rats in the VILI and LX4
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Changes in Peripheral Blood Neutrophils, Lymphocytes and IL-10 in Children with Kawasaki Disease from Different Age Groups Undergoing Intravenous Immunoglobulin: A Retrospective Study Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-19 Chun Zhang; Xuan Zhang; Jia Shen; Xiaotong Lu; Jian Zhang; Sun Chen
Immunoglobulin intravenous (IVIG) is widely used in mucocutaneous lymph node syndrome, known as Kawasaki disease (KD). However, the patients’ inflammatory response during usage remains unclear. In the present study, the association between inflammatory response and lymphocyte count in children with KD from different ages was evaluated before and after IVIG. The medical records of 50 children with KD
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The Effects of Targeted Temperature Management on Oxygen-Glucose Deprivation/Reperfusion-Induced Injury and DAMP Release in Murine Primary Cardiomyocytes Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-18 Giang Tong; Phuong D. Lam; Franka Brey; Jana Krech; Sylvia J. Wowro; Nalina N. A. von Garlen; Felix Berger; Katharina R. L. Schmitt
Introduction. Ischemia/Reperfusion (I/R) is a primary cause of myocardial injury after acute myocardial infarction resulting in the release of damage-associated molecular patterns (DAMPs), which can induce a sterile inflammatory response in the myocardial penumbra. Targeted temperature management (TTM) after I/R has been established for neuroprotection, but the cardioprotective effect remains to be
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Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-18 Shuaiwei Wang; Yafang Sun; Yu Bai; Nannan Zhou; Na Chen; Edmund J. Miller; Yijie Zhang; Wei Li
Connexin (Cx) family members form hemichannels (HCs) and gap junctions (GJs). Biological functions of Cx HCs have not been adequately characterized due to the inability to selectively target HCs or GJs. Recently, we developed a 6-mer peptide mimetic (P5) of the first extracellular loop of Cx43 and showed that it can block the permeability of HCs but not GJs formed by Cx43. In this study, we further
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Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies Mediat. Inflamm. (IF 3.758) Pub Date : 2020-11-17 Shannon Galyean; Dhanashree Sawant; Andrew C. Shin
Background. Obesity is associated with the gut microbiota and decreased micronutrient status. Bariatric surgery is a recommended therapy for obesity. It can positively affect the composition of the gut bacteria but also disrupt absorption of nutrients. Low levels of micronutrients can affect metabolic processes, like glycolysis, TCA cycle, and oxidative phosphorylation, that are associated with the
更新日期:2020-11-17