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  • Conserved hla binding peptides from five non-structural proteins of sars-cov-2—an in silico glance
    Hum. Immunol. (IF 2.412) Pub Date : 2020-08-13
    Jose Marchan

    Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. Bioinformatics represent an outstanding approach to reveal key immunogenic regions in viral proteins. Here, five non-structural proteins (NSP) of SARS-CoV-2 (NSP7, NSP8, NSP9, NSP12, and NSP13) were screening for potential human leukocyte antigen (HLA) binding peptides. These peptides showed

    更新日期:2020-08-14
  • Phenotypic analysis of T follicular helper and T follicular regulatory cells in primary selective IgM deficiency.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-08-07
    Taissa de M Kasahara,Cleonice Alves de Melo Bento,Sudhir Gupta

    Selective IgM deficiency (SIgMD) is a rare immunodeficiency characterized by serum IgM below two standard of mean, and normal IgG and IgA levels. Both in human and mice with selective IgM deficiency, germinal centers cells are decreased. The development of germinal center and humoral immunity are regulated in part by follicular helper T (TFH) and follicular regulatory T (TFR) cells. However, the analysis

    更新日期:2020-08-08
  • A profile of TNFR2+ regulatory T cells and CD103+ dendritic cells in the peripheral blood of patients with asthma.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-08-06
    Nor Azrini Azid,Suhana Ahmad,Jennifer C Boer,Mohammad A I Al-Hatamleh,Nurashikin Mohammad,Noor Suryani Mohd Ashari,Hern Tze Tan,Xin Chen,Magdalena Plebanski,Rohimah Mohamud

    The interaction of tolerogenic CD103+ dendritic cells (DCs) with regulatory T (Tregs) cells modulates immune responses by inducing immune tolerance. Hence, we determined the proportion of these cells in the peripheral blood mononuclear cells (PBMC) of asthmatic patients. We observed lower trends of CD11b-CD103+ DCs and CD86 within CD11b-CD103+ DCs, while increased levels of Foxp3 expressing CD25+/-TNFR2+

    更新日期:2020-08-06
  • Prevalence of AT1R antibody (AT1R-Ab) among Malaysian multi-ethnic population.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-29
    Maisarah Jalalonmuhali,Rob Caroll,Sue Deayton,Tim Emery,Ian Humphreys,Soo Jin Lim,Soo Kun Lim,Toby Coates

    Background Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of AT1R-Ab among the Malaysian population. Methodology All sera for AT1R-Ab were collected

    更新日期:2020-07-29
  • Computational design of a novel multi-epitope vaccine against Coxiella burnetii.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-24
    Amin Jaydari,Narges Nazifi,Ali Forouharmehr

    Query fever is a zoonotic disease caused by Coxiella burnetii. There is no universal method for the prevention of this disease. Recombinant vaccine is a potent strategy that can be utilized for this purpose. The current study was conducted to develop a multi-epitope vaccine against Coxiella burnetii. Hence, OmpA, Tuf2, GroEL, Mip and sucB antigens were used for the prediction of epitopes. Then, a multi-epitope

    更新日期:2020-07-25
  • Subclinical inflammation in the preclinical phase of rheumatoid arthritis might contribute to articular joint damage.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-18
    Mariela Gomez-Moreno,Elsy Janet Ramos-González,Julio Enrique Castañeda-Delgado,José Dionicio Castillo-Ortiz,Cesar Ramos-Remus,Martin Zapata-Zúñiga,J Alfredo Méndez,Adriana Monsiváis-Urenda,Diana Patricia Portales-Pérez,José Antonio Enciso-Moreno,Yadira Bastián

    The first degree relatives of rheumatoid arthritis (RA) patients have a higher risk of developing RA, which is related to the expression of autoantibodies against citrullinated proteins (ACPA). Remarkably, prior to the onset of RA, cartilage damage is already initiated, whereas ACPA autoantibodies are already expressed. Here we show that both TNF-α and IL-6 are also increased prior to the onset of

    更新日期:2020-07-18
  • Association of HLA class II (-DRB1,-DQB1,-DPB1) alleles and haplotypes on susceptibility to aplastic anemia in northern Chinese Han.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-18
    Jun Qi,Tian-Ju Wang,Heng-Xin Li,Di Wu,Dan Du,Jun-Hua Wu,Li-Xia Shang,Le Chen,Man-Ni Wang,Xiao-Fang Wang

    The Human Leukocyte Antigen (HLA) genes, playing key roles in mediating the immune response, especially HLA class II alleles were suggested to play a role in the activation of autoreactive T-cells in aplastic anemia (AA). Previous studies in different ethnic groups have indicated that some of HLA-A,-B,-DRB1 alleles had a protective or susceptive association with the prevalence, pathogenesis and development

    更新日期:2020-07-18
  • A simple electronic tool for assessing amino acid sequence polymorphisms within exon-2 of HLA-DPB1 alleles.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-16
    H Clifford Sullivan,Loren Gragert,Geoffrey H Smith,Kelsi Lindblad,Howard M Gebel,Robert A Bray

    In November 2014, the OPTN/UNOS Board of Directors mandated that HLA-DPB1 typing be performed for all deceased donors. Currently, there are over 1,000 known HLA DPB1 alleles, yet fewer than 30 are represented on commonly used single antigen bead (SAB) solid phase antibody assays. Moreover, the official World Health Organization (WHO) nomenclature for the DPB1 locus does not permit assessment of structural

    更新日期:2020-07-17
  • Genetic polymorphisms of proteasome subunit genes of the MHC-I antigen-presenting system are associated with cervical cancer in a Chinese Han population.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-16
    Chuanyin Li,Shuying Dai,Zhiling Yan,Xinwen Zhang,Shuyuan Liu,Xia Wang,Jun Wang,Li Shi,Yufeng Yao

    Proteasome subunit beta types 8 and 9 (PSMB8, PSMB9) play critical roles in the human leukocyte antigen class I (HLA I)-presenting system. Studies have suggested that polymorphisms in the PSMB8 and PSMB9 genes may influence the immune functions of PSMB8 and PSMB9, and thus be associated with various human cancers. We investigated associations involving single nucleotide polymorphisms (SNPs) rs2071543

    更新日期:2020-07-17
  • Frequencies and haplotype associations of non-expressed HLA alleles in ethnically diverse populations on the National Marrow Donor Program's Be The Match Registry.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-16
    Miranda Bauer,Jane Kempenich,Kimberly Wadsworth,Craig Malmberg,Beth Beduhn,Jason Dehn

    HLA allele matching is critical to successful bone marrow transplantation between a patient and donor. Non-functional HLA alleles, so called ‘null alleles’, are not well described within a large population of well HLA-typed ethnically diverse individuals despite their impact on donor selection. A retrospective analysis was performed on 833,789 unrelated donors (URDs) in the National Marrow Donor Program’s

    更新日期:2020-07-16
  • Physical Crossmatching vs Virtual Crossmatching: The end of an era? or Why give up a good thing?
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-16
    H Clifford Sullivan,Scott M Krummey,Howard M Gebel,Robert A Bray,Annette M Jackson

    更新日期:2020-07-16
  • Next-generation sequencing of 11 HLA loci in a large dengue vaccine cohort from the Philippines.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-09
    Aviva Geretz,Lauryn Cofer,Philip K Ehrenberg,Jeffrey R Currier,In-Kyu Yoon,Maria T P Alera,Richard Jarman,Alan L Rothman,Rasmi Thomas

    HLA genotyping by next-generation sequencing (NGS) has evolved with significant advancements in the last decade. Here we describe full-length HLA genotyping of 11 loci in 612 individuals comprising a dengue vaccine cohort from Cebu province in the Philippines. The multi-locus individual tagging NGS (MIT-NGS) method that we developed initially for genotyping 4–6 loci in one MiSeq run was expanded to

    更新日期:2020-07-09
  • The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-08
    Rodrigo Barquera,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Esteban Arrieta-Bolaños,Stephen Clayton,Víctor Acuña-Alonzo,Julio César Martínez-Álvarez,Concepción López-Gil,Carmen Adalid-Sáinz,María Del Rosario Vega-Martínez,Araceli Escobedo-Ruíz,Eva Dolores Juárez-Cortés,Alexander Immel,Hanna Pacheco-Ubaldo,Liliana González-Medina,Abraham Lona-Sánchez,Julio Lara-Riegos,María Guadalupe de Jesús

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the

    更新日期:2020-07-08
  • Regulatory noncoding RNAs and the major histocompatibility complex.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-07-04
    Nilesh Sunil Chitnis,Mengkai Shieh,Dimitri Monos

    The Major Histocompatibility Complex (MHC) is a 4 Mbp genomic region located on the short arm of chromosome 6. The MHC region contains many key immune-related genes such as Human Leukocyte Antigens (HLAs). There has been a growing realization that, apart from MHC encoded proteins, RNAs derived from noncoding regions of the MHC—specifically microRNAs (miRNAs) and long noncoding RNAs (lncRNAs)—play a

    更新日期:2020-07-06
  • HLA-A -B and -DRB1 distribution in Kami: A caste population of Gorkha community from the sub-Himalayan region of West Bengal, India.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-29
    Bisu Singh,Dependra Chamlagai,Jiwan Gurung

    The present investigation is the first of its kind to understand the HLA profile of Kami population from the Indian Gorkha community of sub-Himalayan West Bengal, India. A total of 158 individuals from Kami population were genotyped at first field resolution by HLA ABDRB1 PCR SSP typing kit. The genotype assignment to the individuals was performed by Ready Gene V.1.0.0.0′ software. The data were analysed

    更新日期:2020-06-30
  • Utilizing nanopore sequencing technology for the rapid and comprehensive characterization of eleven HLA loci; addressing the need for deceased donor expedited HLA typing.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-25
    Timothy L Mosbruger,Amalia Dinou,Jamie L Duke,Deborah Ferriola,Hilary Mehler,Ioanna Pagkrati,Georgios Damianos,Eric Mbunwe,Mahdi Sarmady,Ioannis Lyratzakis,Sarah A Tishkoff,Anh Dinh,Dimitri S Monos

    The comprehensive characterization of human leukocyte antigen (HLA) genomic sequences remains a challenging problem. Despite the significant advantages of next-generation sequencing (NGS) in the field of Immunogenetics, there has yet to be a single solution for unambiguous, accurate, simple, cost-effective, and timely genotyping necessary for all clinical applications. This report demonstrates the

    更新日期:2020-06-25
  • HLA-A, -B, and -DRB1 genotyping and haplotype frequencies among Filipinos living in the National Capital Region of the Philippines.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-19
    Emilio Q Villanueva,Chi-Cheng Li,Py-Yu Lin,Kuo-Liang Yang

    In this report, HLA polymorphisms (A, B, and DRB1 loci) were determined in 51 unrelated Filipinos. Molecular genotyping was carried out by sequence-based typing (Sanger sequencing). Data were analyzed by HLA-net GENE[RATE] tools. HLA-A, -B and -DRB1 genotype frequencies were at Hardy-Weinberg equilibrium. A*11, B*15, and DRB1*15 were the most frequent allele groups, while A*11-B*15-DRB1*15 was the

    更新日期:2020-06-19
  • Concordance between predicted HLA type using next generation sequencing data generated for non-HLA purposes and clinical HLA type.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-13
    Ann M Moyer,Brian Dukek,Patti Duellman,Brittany Schneider,Laurie Wakefield,Jennifer M Skierka,Rajeswari Avula,Aditya V Bhagwate,Krishna R Kalari,Justin D Kreuter,Matthew P Goetz,Judy C Boughey,John L Black,Manish J Gandhi

    We explored the feasibility of obtaining accurate HLA type using pre-existing NGS data not generated for HLA purposes. 83 exomes and 500 targeted NGS pharmacogenomic panels were analyzed using Omixon HLA Explore, OptiType, and/or HLA-Genotyper software. Results were compared against clinical HLA genotyping. 765 (94.2%) Omixon and 769 (94.7%) HLA-Genotyper of 812 germline allele calls across class I/II

    更新日期:2020-06-13
  • Genetics of Mexico Jamiltepec Oaxaca Mixtec Amerindians according to HLA genes.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-11
    Antonio Arnaiz-Villena,Fabio Suarez-Trujillo,Adrian Lopez-Nares,Estefania Crespo-Yuste,Alvaro Callado,Ignacio Juarez

    Mexican Mixtec population from coastal Jamiltepec (Oaxaca) Amerindians was studied for its HLA profile. They show genetic characteristics close to Pacific Islanders and other Mexican Isthmus Amerindians (Mazatecans, Zapotecans and Mayas). Interestingly, this coastal Oaxaca Mixtec population is genetically closer to Mazatecans than to Oaxaca Mixtec from mountains according to HLA genes. Mixtec HLA frequent

    更新日期:2020-06-11
  • T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-10
    Xiaomei Ma,Jie Zha,Jixiang He,Longtian Chen,Jianqing Huang,Weihao Wu,Pan Tian,Bao-Hua Qian,Lian Yu,Yirong Jiang,Bing Xu

    Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25− Tfh subset (CD25−CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could suppress CD8 T cell response while promote tumor cell proliferation. In this study, we

    更新日期:2020-06-10
  • 更新日期:2020-06-07
  • Clinical utility of next generation sequencing based HLA typing for disease association and pharmacogenetic testing.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-06-01
    Tracie Profaizer,Ann Pole,Cassandra Monds,Julio C Delgado,Eszter Lázár-Molnár

    HLA associations have been linked to many diseases and are important for risk assessment of drug hypersensitivity reactions. The increasing number of HLA alleles discovered generated a list of ambiguities that cannot be resolved with the current clinical assays, which commonly include sequence-specific oligonucleotide probe (SSOP) genotyping, and real-time PCR with melting curve analysis. HLA typing

    更新日期:2020-06-01
  • Distribution of CD36 deficiency in different Chinese ethnic groups.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-05-31
    Jing Liu,Yuan Shao,Haoqiang Ding,Jing Deng,Xiuzhang Xu,Jiali Wang,Wenjie Xia,Sentot Santoso,Xin Ye,Yongshui Fu

    Background CD36 is a multifunctional receptor in cells that plays a role in important cellular processes including immune regulation. Evidence indicates that mutations in the CD36 gene are associated with malaria. Moreover, studies on the frequency of CD36 deficiency have been conducted in specific provinces of China. However, the frequency of CD36 deficiency may differ among various ethnic populations

    更新日期:2020-05-31
  • Non-donor specific anti-human leukocyte antigen (HLA) antibodies are not associated with poor outcome in hematopoietic stem cell transplant recipients.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-05-26
    J R Andolina,R Walia,J Oliva,A Baran,J Liesveld,M W Becker,A Busacco,M Coppage

    Testing for anti-human leukocyte antigen (HLA) antibodies has now become standard practice in allogeneic hematopoietic stem cell transplantation (HSCT), and anti-HLA antibodies (both donor specific and non-donor specific) are being identified and have many potential consequences. Most studies suggest that donor-specific HLA antibodies lead to adverse outcomes, though little is reported on non-donor

    更新日期:2020-05-26
  • CD1 gene polymorphism and susceptibility to celiac disease: Association of CD1E*02/02 in Moroccans.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-05-25
    Anna Aureli,Sara Aboulaghras,Khadija Oumhani,Tiziana Del Beato,Pierluigi Sebastiani,Alessia Colanardi,Rajae El Aouad,Imane Ben El Barhdadi,Daniela Piancatelli

    CD1 glycoproteins are a class of antigen presenting molecules that bind and present non-peptidic antigens (lipids and glycolipids) for immune recognition. CD1 polymorphisms, although limited, could have a critical role in antimicrobial, anticancer, and autoimmune responses and disease susceptibility. Ethnic differences and interactions between genetic and environmental factors make it attractive the

    更新日期:2020-05-25
  • HLA study in Bolivian Quechua Amerindians from Titikaka Lake Area.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-05-14
    Antonio Arnaiz-Villena,Ignacio Juarez,Adrian Lopez-Nares,Estefania Crespo-Yuste,Alvaro Callado,Fabio Suarez-Trujillo

    Quechua Amerindians established Inca Empire and chose Cuzco as their capital. Their language is closely related to that of Aymara ethnic group and both of them were originated from Titikaka Lake Altiplano area. In the present study we have analyzed Bolivian Quechua HLA profile and found that it has common characters with other Andean and Pacific Amerindians (Uros, Aymaras, Lamas, Mapuches, Athabascan)

    更新日期:2020-05-14
  • Naming HLA diversity: A review of HLA nomenclature.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-05-08
    Carolyn Katovich Hurley

    The development of a standardized HLA nomenclature has been critical in our understanding of the HLA system and in facilitating the clinical applications of HLA. The Nomenclature Committee for Factors of the HLA System, established in 1968, has overseen the development and usage of nomenclature based on serologic specificities, cellular responses, and DNA sequences. Their decisions have been guided

    更新日期:2020-05-08
  • A long road/read to rapid high-resolution HLA typing: The nanopore perspective.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-05-01
    Chang Liu

    Next-generation sequencing (NGS) has been widely adopted for clinical HLA typing and advanced immunogenetics researches. Current methodologies still face challenges in resolving cis-trans ambiguity involving distant variant positions, and the turnaround time is affected by testing volume and batching. Nanopore sequencing may become a promising addition to the existing options for HLA typing. The technology

    更新日期:2020-05-01
  • Detecting mismatched donor HLA types from allograft biopsies - An easily applicable tool for improved individualized risk assessment.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-04-29
    Randi Berg,Maja Nørgaard,Mie Topholm Bruun,Mette Christiansen,Pernille Koefoed-Nielsen

    Short-term allograft survival has improved among solid organ transplant (SOT) patients. An increasing number of SOT patients are prepared for re-transplantation because of chronic allograft failure. Lack of HLA typing or incomplete HLA typing of previous donors complicates pretransplant risk assessment, as repeated HLA mismatches may be missed. In addition, a complete HLA type of the donor is essential

    更新日期:2020-04-29
  • Distribution of HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in Jingpo minority in Yunnan province of China.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-04-29
    Yufen Tao,Lei Shi,Shuyuan Liu,Yufeng Yao,Li Shi

    HLA-A, HLA-B, HLA-C, and HLA-DRB1 allele frequencies and estimated haplotype frequencies from 105 unrelated healthy Jingpo ethnic subjects who living in Dehong Dai-Jingpo Autonomous Prefectures, Yunnan Province, southwest China has been reported. HLA genes were genotyped by SSOP typing method using Luminex Multi-Analyte Profiling system. Jingpo ethnic nationality belongs to southern group of East Asians

    更新日期:2020-04-29
  • Novel immunological approach to asses donor reactivity of transplant recipients using a humanized mouse model.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-04-25
    Yasutomo Fukasaku,Ryoichi Goto,Yoshikazu Ganchiku,Shin Emoto,Masaaki Zaitsu,Masaaki Watanabe,Norio Kawamura,Moto Fukai,Tsuyoshi Shimamura,Akinobu Taketomi

    In organ transplantation, a reproducible and robust immune-monitoring assay has not been established to determine individually tailored immunosuppressants (IS). We applied humanized mice reconstituted with human (hu-) peripheral blood mononuclear cells (PBMCs) obtained from living donor liver transplant recipients to evaluate their immune status. Engraftment of 2.5 × 106 hu-PBMCs from healthy volunteers

    更新日期:2020-04-25
  • A role for both HLA-F and HLA-G in reproduction and during pregnancy?
    Hum. Immunol. (IF 2.412) Pub Date : 2019-09-24
    Gry Persson,Nanna Jørgensen,Line Lynge Nilsson,Lærke Heidam J Andersen,Thomas Vauvert F Hviid

    The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases

    更新日期:2020-04-21
  • HLA-G +3196 polymorphism as a risk factor for cell mediated rejection following heart transplant.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-01-09
    Mitchell B Adamson,Bennett Di Giovanni,Roberto V P Ribeiro,Frank Yu,Julieta Lazarte,Vivek Rao,Diego H Delgado

    BACKGROUND Rejection is a leading cause of mortality following heart transplantation. Human leukocyte antigen-G (HLA-G) is an immune checkpoint which dampens the immune response. Reports suggest elevated HLA-G expression is associated with reduced allograft rejection. Our objective was to evaluate HLA-G polymorphisms and cell mediated rejection (CMR) development. METHODS Recipients (n = 123) were genotyped

    更新日期:2020-04-21
  • HLA-G 3' untranslated region gene variants are promising prognostic factors for BK polyomavirus replication and acute rejection after living-donor kidney transplant.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-10-31
    Hana Rohn,Esther Schwich,Rafael Tomoya Michita,Sabine Schramm,Sebastian Dolff,Anja Gäckler,Johannes Korth,Falko M Heinemann,Benjamin Wilde,Mirko Trilling,Peter A Horn,Andreas Kribben,Oliver Witzke,Vera Rebmann

    The immunosuppressive non-classical human leukocyte antigen-G (HLA-G) promotes transplant tolerance as well as viral immune escape. HLA-G expression is associated with regulatory elements targeting certain single nucleotide polymorphisms (SNPs) in the HLA-G 3' untranslated region (UTR). Thus, we evaluated the impact of HLA-G 3'UTR polymorphisms as surrogate markers for BK polyomavirus (BKPyV) replication

    更新日期:2020-04-21
  • Soluble HLA-G pre-transplant levels to identify the risk for development of infection in heart transplant recipients.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-10-31
    Daria Bortolotti,Valentina Gentili,Antonella Rotola,Luciano Potena,Roberta Rizzo

    Infection is still a leading cause of death during the first year after heart transplantation. We evaluated the pre-transplant levels of HLA (Human Leukocyte antigen) - G molecules as a means of identifying heart recipients at risk of serious infections. We prospectively analyzed 122 adult heart transplant (HT) recipients. Serum samples were collected beforetransplantation and analyzed for sHLA-G levels

    更新日期:2020-04-21
  • Plasma soluble HLA-G levels in a cohort of heart failure patients exposed to chemicals
    Hum. Immunol. (IF 2.412) Pub Date : 2019-12-02
    Daria Bortolotti; Emanuela Vitali; Mariarita Stendardo; Alessandro Fucili; Roberta Rizzo; Piera Boschetto

    Heart failure (HF) is a syndrome caused by structural and/or functional cardiac abnormalities, resulting in a reduced cardiac output and/or elevated intracardiac pressures. Several studies reported a crucial role of immune activation and inflammation in the chronic heart failure (HF) pathogenesis, suggesting that pro-inflammatory and anti-inflammatory mediators could be predictive markers of the HF

    更新日期:2020-04-21
  • Detection of serum soluble HLA-G levels in patients with acute ischemic stroke: A pilot study.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-11-15
    Enrico Fainardi,Daria Bortolotti,Massimiliano Castellazzi,Ilaria Casetta,Tiziana Bellini,Roberta Rizzo

    The aim of this study was to investigate the potential role of soluble Human Leukocyte Antigen-G (sHLA-G) molecules as biomarkers predicting outcome in acute ischemic stroke (AIS). Serum levels of total sHLA-G (sHLA-G1/HLA-G5) and its soluble isoforms sHLA-G1 and HLA-G5/G6 were measured by enzyme-linked immunosorbent assay (ELISA) in 92 AIS patients and healthy donors (HD). Incidence of hemorrhagic

    更新日期:2020-04-21
  • Expression of membrane-bound human leucocyte antigen-G in systemic sclerosis and systemic lupus erythematosus
    Hum. Immunol. (IF 2.412) Pub Date : 2019-12-14
    Simone Negrini; Paola Contini; Francesca Pupo; Monica Greco; Giuseppe Murdaca; Francesco Puppo

    Human leucocyte antigen-G (HLA-G) is a nonclassical class I major histocompatibility complex (MHC) molecule characterized by complex immunoregulatory and tolerogenic functions. Membrane-bound HLA-G is expressed on the surface of different cell populations in both physiological and pathological conditions. Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by widespread tissue

    更新日期:2020-04-21
  • Cytometry-based analysis of HLA-G functions according to ILT2 expression.
    Hum. Immunol. (IF 2.412) Pub Date : 2020-02-18
    A Jacquier,C Dumont,E D Carosella,N Rouas-Freiss,J LeMaoult

    HLA-G was described as a molecule inhibiting NK and T cells functions through its receptor, ILT2. However, most functional studies of HLA-G were so far performed on heterogeneous immune populations and regardless of ILT2 expression. This may lead to an underestimation of the effect of HLA-G. Thus, considering the immune subpopulations sensitive to HLA-G remained an important issue in the field. Here

    更新日期:2020-04-21
  • HLA-G and humanized mouse models as a novel therapeutic approach in transplantation
    Hum. Immunol. (IF 2.412) Pub Date : 2020-02-21
    Ashwin Ajith; Vera Portik-Dobos; Daniel D. Horuzsko; Rajan Kapoor; Laura L. Mulloy; Anatolij Horuzsko

    HLA-G is a nonclassical MHC-Class I molecule whose expression, along the feto-maternal barrier contributes towards tolerance of the semiallogeneic fetus during pregnancy. In light of its inhibitory properties, recent research has established HLA-G involvement in mechanisms responsible for directing allogeneic immune responses towards tolerance during allogeneic situations such as organ transplantation

    更新日期:2020-04-21
  • Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-11-14
    Hiroshi Watanabe,Kimiko Kuroki,Chisato Yamada,Yukari Saburi,Naoyoshi Maeda,Katsumi Maenaka

    Human leukocyte antigen (HLA)-G, a non-classical HLA class I molecule, has one of the splicing isoforms, HLA-G2, which lacks one domain (α2) and forms a non-covalent homodimer. HLA-G2 is expressed on placental cells, regulatory T cells, tumor cells, and virus-infected cells, and is involved in immunosuppression. The major isoform of HLA-G, HLA-G1, binds to leukocyte immunoglobulin (Ig)-like receptor

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-25
    Julio César Martínez-Álvarez,Rodrigo Barquera,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Stephen Clayton,Esteban Arrieta-Bolaños,Alexander Immel,Gamaliel Benítez-Arvizu,María Araceli Arrazola-García,Vicencio Juárez-Barreto,María Del Rosario Vega-Martínez,Francisco Juárez-Nicolás,Ariadna Berenice Escutia-González,Virginia Martínez-Bezies,Raquel García-Álvarez,Norma Salgado-Galicia,Joaquín Zúñiga

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one

    更新日期:2020-04-21
  • Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-25
    Rodrigo Barquera,Julio César Martínez-Álvarez,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Francisco Juárez-Nicolás,Agustín Jericó Arriaga-Perea,María Del Rosario Vega-Martínez,Andrea Ortega-Yáñez,Gamaliel Benítez-Arvizu,Esteban Arrieta-Bolaños,Stephen Clayton,Eva Dolores Juárez-Cortés,Concepción López-Gil,Raquel García-Álvarez,María Araceli Arrazola-García,Virginia Martínez-Bezies,Vicencio

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtain information regarding allelic and haplotypic frequencies. We found that the most

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from San Luis Potosí, Mexico: San Luis Potosí City and rural San Luis Potosí.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-24
    Diana Iraíz Hernández-Zaragoza,Tirzo Jesús Rodríguez-Munguía,Rodrigo Barquera,Carmen Adalid-Sáinz,Esteban Arrieta-Bolaños,Stephen Clayton,Hanna Pacheco-Ubaldo,Liliana González-Medina,Abraham Lona-Sánchez,Alicia Bravo-Acevedo,Guadalupe Aquino-Rubio,Marisela Del Rocío González-Martínez,Héctor Delgado-Aguirre,Néstor Escareño-Montiel,Yolanda Jaramillo-Rodríguez,Antonio Salgado-Adame,Federico Juárez-de

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 117 Mexicans from the state of San Luis Potosí living in the city of San Luis Potosí (N = 30) and rural communities (N = 87), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state include 13 Native American, six European, two African

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-23
    Raúl Solís-Martínez,Rodrigo Barquera,Komathi Sree Ponnandai-Shanmugavel,María Del Rosario Vega-Martínez,Tannya Verónica Vázquez-Castillo,Esteban Arrieta-Bolaños,Stephen Clayton,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Alexander Immel,Norma Salgado-Galicia,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture

    更新日期:2020-04-21
  • Genetic diversity of HLA system in seven populations from Veracruz, Mexico: Veracruz city, Coatzacoalcos, Córdoba, Orizaba, Poza Rica, Xalapa and rural Veracruz.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-23
    Rodrigo Barquera,Concepción López-Gil,Víctor Acuña-Alonzo,María Del Rosario Vega-Martínez,Tirzo Jesús Rodríguez-Munguía,Julio César Martínez-Álvarez,Esteban Arrieta-Bolaños,Stephen Clayton,Flor Del Rocío Ramos-de la Cruz,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Gamaliel Benítez-Arvizu,María Araceli Arrazola-García,Guadalupe Aquino-Rubio,Vicencio Juárez-Barreto,Patricia Méndez-Mani,Tannya

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1113 Mexicans from the state of Veracruz living in the cities of Coatzacoalcos (N = 55), Orizaba (N = 60), Córdoba (N = 56), Poza Rica (N = 45), Veracruz (N = 171), Xalapa (N = 187) and rural communities (N = 539) to obtain information regarding allelic and haplotypic frequencies. We found that the

    更新日期:2020-04-21
  • Genetic diversity of HLA system in three populations from Coahuila, Mexico: Torreón, Saltillo and rural Coahuila.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-23
    Carmen Adalid-Sáinz,Rodrigo Barquera,Michael H Crawford,Abraham Lona-Sánchez,Stephen Clayton,Esteban Arrieta-Bolaños,Héctor Delgado-Aguirre,Liliana González-Medina,Hanna Pacheco-Ubaldo,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Néstor Escareño-Montiel,Javier Morán-Martínez,Marisela Del Rocío González-Martínez,Yolanda Jaramillo-Rodríguez,Antonio Salgado-Adame,Federico Juárez-de la Cruz,Joaquín

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (N = 72), Torreón (N = 396) and rural communities (N = 216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Puebla, Mexico: Puebla city and rural Puebla.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Concepción López Gil,Rodrigo Barquera,María de Los Ángeles Pavón-Vargas,Flor Del Rocío Ramos-de la Cruz,Patricia Méndez-Mani,Esteban Arrieta-Bolaños,Stephen Clayton,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2827 Mexicans from the state of Puebla living in the city of Puebla (N = 1994) and rural communities (N = 833), to obtain information regarding allelic and haplotypic frequencies. We found that the 16 most frequent haplotypes in Puebla are all of them Native American. Admixture estimates revealed that

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Tamaulipas, Mexico: Ciudad Victoria and rural Tamaulipas.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Tirzo Jesús Rodríguez-Munguía,Rodrigo Barquera,Carmen Adalid-Sáinz,Diana Iraíz Hernández-Zaragoza,Esteban Arrieta-Bolaños,Stephen Clayton,Guadalupe Aquino-Rubio,Marisela Del Rocío González-Martínez,Hanna Pacheco-Ubaldo,Liliana González-Medina,Abraham Lona-Sánchez,Alicia Bravo-Acevedo,Héctor Delgado-Aguirre,Néstor Escareño-Montiel,Yolanda Jaramillo-Rodríguez,Antonio Salgado-Adame,Federico Juárez-de

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 148 Mexicans from the state of Tamaulipas living in Ciudad Victoria (N = 23) and rural communities (N = 125), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Tamaulipas include ten Native American, three European and one

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Quintana Roo, Mexico: Cancún and rural Quintana Roo.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Carolina Elizabeth Medina-Escobedo,Rodrigo Barquera,Komathi Sree Ponnandai-Shanmugavel,Julio Lara-Riegos,Alicia Bravo-Acevedo,Esteban Arrieta-Bolaños,Stephen Clayton,Diana Iraíz Hernández-Zaragoza,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 98 Mexicans from the state of Quintana Roo living in the city of Cancún (N = 48) and rural communities (N = 50), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We found that the most frequent haplotypes in Quintana Roo include ten Native American

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Rodrigo Barquera,Julio Lara-Riegos,Komathi Sree Ponnandai-Shanmugavel,Alexander Immel,Esteban Arrieta-Bolaños,Stephen Clayton,Raúl Solís-Martínez,Alicia Bravo-Acevedo,Tannya Verónica Vázquez-Castillo,Diana Iraíz Hernández-Zaragoza,María Del Rosario Vega-Martínez,Norma Salgado-Galicia,Carolina Elizabeth Medina-Escobedo,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (N = 34) and rural communities (N = 47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Rodrigo Barquera,Francisco Juárez-Nicolás,Julio César Martínez-Álvarez,Komathi Sree Ponnandai-Shanmugavel,Diana Iraíz Hernández-Zaragoza,Tannya Verónica Vázquez-Castillo,Esteban Arrieta-Bolaños,Stephen Clayton,Raúl Solís-Martínez,Andrea Ortega-Yáñez,María Araceli Arrazola-García,Alexander Immel,Alicia Bravo-Acevedo,María Del Rosario Vega-Martínez,Gamaliel Benítez-Arvizu,Raquel García-Álvarez,Virginia

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (N = 52) and rural communities (N = 121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Tlaxcala, Mexico: Tlaxcala city and rural Tlaxcala.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    María de Los Ángeles Pavón-Vargas,Michael H Crawford,Rodrigo Barquera,Concepción López-Gil,Esteban Arrieta-Bolaños,Stephen Clayton,Diana Iraíz Hernández-Zaragoza,Alicia Bravo-Acevedo,Flor Del Rocío Ramos-de la Cruz,Patricia Méndez-Mani,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1011 Mexicans from the state of Tlaxcala residing in the city of Tlaxcala (N = 181) and rural communities (N = 830), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in Tlaxcala are all of Native American origin. Admixture estimates revealed

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Julio Lara-Riegos,Rodrigo Barquera,Oana Del Castillo-Chávez,Carolina Elizabeth Medina-Escobedo,Diana Iraíz Hernández-Zaragoza,Esteban Arrieta-Bolaños,Stephen Clayton,Komathi Sree Ponnandai-Shanmugavel,Alicia Bravo-Acevedo,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Yucatán include 16 Native American and one European haplotype

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Hidalgo, Mexico: Pachuca and rural Hidalgo.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Rodrigo Barquera,Julio César Martínez-Álvarez,Alondra Victoria Trejo-Ordoz,María de Los Ángeles Pavón-Vargas,María Del Rosario Vega-Martínez,Esteban Arrieta-Bolaños,Stephen Clayton,Andrea Ortega-Yáñez,Eva Dolores Juárez-Cortés,Francisco Juárez-Nicolás,Concepción López-Gil,Alexander Immel,María Araceli Arrazola-García,Vicencio Juárez-Barreto,Gamaliel Benítez-Arvizu,Agustín Jericó Arriaga-Perea,Virginia

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 122 Mexicans from the state of Hidalgo living in the city of Pachuca (N = 41) and rural communities (N = 81), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in Hidalgo include eight Native American and one European haplotypes. Admixture

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Andrea Ortega-Yáñez,Rodrigo Barquera,Laura Curiel-Giles,Julio César Martínez-Álvarez,Rosa María Macías-Medrano,Esteban Arrieta-Bolaños,Stephen Clayton,Alicia Bravo-Acevedo,Diana Iraíz Hernández-Zaragoza,Alexander Immel,María Del Rosario Vega-Martínez,Gamaliel Benítez-Arvizu,María Araceli Arrazola-García,Agustín Jericó Arriaga-Perea,Eva Dolores Juárez-Cortés,Vicencio Juárez-Barreto,Norma Salgado-Galicia

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (N = 82) and rural communities (N = 30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-07-22
    Ofelia Hernández-Hernández,Diana Iraíz Hernández-Zaragoza,Rodrigo Barquera,Christina Warinner,Concepción López-Gil,Esteban Arrieta-Bolaños,Stephen Clayton,Alicia Bravo-Acevedo,Flor Del Rocío Ramos-de la Cruz,Patricia Méndez-Mani,María de Los Ángeles Pavón-Vargas,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 636 Mexicans from the state of Oaxaca living in the city of Oaxaca (N = 151) and rural communities (N = 485), to obtain information regarding allelic and haplotypic frequencies. We found that the 13 most frequent haplotypes in Oaxaca are all of putative Native American origin. Admixture estimates revealed

    更新日期:2020-04-21
  • Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-06-14
    Jorge Arturo Pantoja-Torres,Rodrigo Barquera,Mónica Ballesteros-Romero,Alicia Bravo-Acevedo,Esteban Arrieta-Bolaños,Gustavo Daniel Montiel-Hernández,Stephen Clayton,Lidia Iris Rodríguez-Rodríguez,Diana Iraíz Hernández-Zaragoza,Isis Goné-Vázquez,Araceli Escobedo-Ruíz,Víctor Eduardo García-Arias,Francia Paulina Arellano-Prado,Marla Estefanía Rodríguez-López,María Guadalupe de Jesús Sánchez-Fernández

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (N = 78), León (N = 22) and rural communities (N = 162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-06-14
    Rodrigo Barquera,Diana Iraíz Hernández-Zaragoza,Francia Paulina Arellano-Prado,Isis Goné-Vázquez,Stephen Clayton,Esteban Arrieta-Bolaños,Araceli Escobedo-Ruíz,Víctor Eduardo García-Arias,Alicia Bravo-Acevedo,Marla Estefanía Rodríguez-López,María Guadalupe de Jesús Sánchez-Fernández,Mario J Sandoval-Sandoval,Benjamín Gómez-Navarro,Joaquín Zúñiga,Edmond J Yunis,Carolina Bekker-Méndez,Julio Granados

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African

    更新日期:2020-04-21
  • Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango.
    Hum. Immunol. (IF 2.412) Pub Date : 2019-06-11
    Liliana González-Medina,Rodrigo Barquera,Héctor Delgado-Aguirre,Stephen Clayton,Carmen Adalid-Sáinz,Esteban Arrieta-Bolaños,Hanna Pacheco-Ubaldo,Diana Iraíz Hernández-Zaragoza,Néstor Escareño-Montiel,Javier Morán-Martínez,Alicia Bravo-Acevedo,Abraham Lona-Sánchez,Marisela Del Rocío González-Martínez,Yolanda Jaramillo-Rodríguez,Antonio Salgado-Adame,Federico Juárez-de la Cruz,Joaquín Zúñiga,Edmond J

    We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 479 Mexicans from the state of Durango living in Durango city (N = 153) and rural communities (N = 326), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Durango include eight Native American and two European haplotypes

    更新日期:2020-04-21
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