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Correction to: Multiple office blood pressure measurement: a novel approach to overcome the weak cornerstone of blood pressure measurement in children. Data from the SPA project Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-11-23 Gianluigi Ardissino, Silvia Ghiglia, Patrizia Salice, Michela Perrone, Sandra Piantanida, Francesco L. De Luca, Silvia Di Michele, Lucia Filippucci, Elena R. A. Dardi, Tiziana Bollani, Antonella Mezzopane, Bertrand Tchana, Sebastiano A. G. Lava
The authors regret that the name of the author Bertrand Tchana was incorrectly rendered as “Bertrand Tchane”. The original article has been corrected.
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Do children with solitary or hypofunctioning kidney have the same prevalence for masked hypertension? Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-18 Sibel Yel, Neslihan Günay, Ayşe Seda Pınarbaşı, Aynur Gencer Balaban, Zeynep Caferoğlu, İsmail Dursun, Muammer Hakan Poyrazoğlu
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Long-term outcomes during 37 years of pediatric kidney transplantation: a cohort study comparing ethnic groups Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-18 Miriam Davidovits, Lewis Reisman, Roxana Cleper, Nathan Bar-Nathan, Irit Krause, Amit Dagan, Neomi Zanhendler, Gabriel Chodick, Osnat Hocherman, Maya Mor, Sigal Aisner, Eytan Mor
Background This study aimed to evaluate short- and long-term outcomes of kidney transplantation over 37 years in a national referral center and compare outcomes between Israeli Jewish and Arab children. Methods Data on 599 pediatric transplantations performed in 545 children during 1981–2017, including demographic parameters, kidney failure disease profile, and pre-transplant dialysis duration, were
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Dilatation of the aorta in children with advanced chronic kidney disease Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-18 Sophie Quennelle, Caroline Ovaert✉, Mathilde Cailliez, Florentine Garaix, Michel Tsimaratos, Fedoua El Louali
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Determination of the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the diagnosis of asymptomatic pulmonary embolism in patients with nephrotic syndrome Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-18 Nasrin Hoseiny nejad, Amin Sadat Sharif, Hasan Otukesh, Rozita Hosseini shamsabadi, Sepideh Hekmat, Maryam Sakhaei
Background Thromboembolism is one of the most important and dangerous complications of nephrotic syndrome. This study aimed to determine the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the prediction of asymptomatic pulmonary embolism in patients with nephrotic syndrome in non-remission period. Methods Plasma levels of albumin, anti-thrombin III, fibrinogen and D-dimer were
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Urinary neutrophil gelatinase-associated lipocalin rules out nephrotoxic acute kidney injury in children Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-18 Stuart L. Goldstein, Kelli A. Krallman, Alexandra Schmerge, Lynn Dill, Bradley Gerhardt, Praneeta Chodaparavu, Abigail Radomsky, Cassie Kirby, David J. Askenazi
Background Nephrotoxic medication exposure is a common cause of acute kidney injury (AKI) in hospitalized children. A key component of the NINJA quality improvement initiative is systematic daily serum creatinine assessment in non-critically ill children exposed to ≥ 3 nephrotoxic medications on 1 day, or intravenous aminoglycoside or vancomycin for ≥ 3 days. Daily venipuncture is invasive and associated
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Correction to: Clinical practice recommendations for the diagnosis and management of Alport syndrome in children, adolescents, and young adults–an update for 2020 Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-12 Clifford E. Kashtan, Oliver Gross
A Correction to this paper has been published: https://doi.org/10.1007/s00467-020-04892-x
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Hemodynamic disturbances and oliguria during continuous kidney replacement therapy in critically ill children Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-12 Sarah N. Fernández Lafever, Jorge López, Rafael González, María J. Solana, Javier Urbano, Jesús López-Herce, Laura Butragueño, María J. Santiago
Background About 1.5% of patients admitted to the Pediatric Intensive Care Unit (PICU) will require continuous kidney replacement therapy (CKRT)/renal replacement therapy (CRRT). Mortality of these patients ranges from 30 to 60%. CKRT-related hypotension (CKRT-RHI) can occur in 19–45% of patients. Oliguria after onset of CKRT is also common, but to date has not been addressed directly in the scientific
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Consensus acute kidney injury criteria integration identifies children at risk for long-term kidney dysfunction after multiple organ dysfunction syndrome Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-11 Stephen M. Gorga, Erin F. Carlton, Joseph G. Kohne, Ryan P. Barbaro, Rajit K. Basu
Background The consensus definition of acute kidney injury (AKI) has evolved since developing the original multiple organ dysfunction syndrome (MODS) definitions. Whether or not risk for adverse short- and long-term outcomes can be identified using the refined AKI criteria in the setting of MODS has not been studied. We hypothesize that incorporation of Kidney Disease: Improving Global Outcome (KDIGO)
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Urinary biomarkers as point-of-care tests for predicting progressive deterioration of kidney function in congenital anomalies of kidney and urinary tract: trefoil family factors (TFFs) as the emerging biomarkers Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-08 Sachit Anand, Minu Bajpai, Tripti Khanna, Alok Kumar
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Reduced urinary excretion of neutrophil gelatinase-associated lipocalin as a risk factor for recurrence of febrile urinary tract infection in children Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Sohsaku Yamanouchi, Takahisa Kimata, Yuko Akagawa, Shohei Akagawa, Jiro Kino, Shoji Tsuji, Kazunari Kaneko
Background This study aimed to test the hypothesis that reduced urinary excretions of neutrophil gelatinase-associated lipocalin (NGAL) predispose children to recurrence of febrile urinary tract infection (fUTI). Methods Subjects were 38 children diagnosed with fUTI. To examine risk factors for recurrence of fUTI, the subjects were divided into a non-recurrent group and a recurrent group according
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24-hour ambulatory blood pressure monitoring 9 years after pediatric cardiac surgery: a pilot and feasibility study Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Daniel Fredric, Jason H. Greenberg, Chirag R. Parikh, Prasad Devarajan, Hayton Chui, Vedran Cockovski, Michael Pizzi, Ana Palijan, Erin Hessey, Yaqi Jia, Heather R. Thiessen-Philbrook, Michael Zappitelli
Background Children undergoing cardiac surgery are at risk of high blood pressure (BP), a risk factor for cardiovascular and kidney disease. Twenty-four-hour ambulatory BP monitoring (ABPM) is a reference standard hypertension (HTN) test. Little data exist on ABPM abnormalities in children several years post cardiac surgery. This study aimed to (a) determine ABPM feasibility; (b) describe and compare
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Outcomes of kidney injury including dialysis and kidney transplantation in pediatric oncology and hematopoietic cell transplant patients Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Natalie L. Wu, Sangeeta Hingorani
Pediatric oncology and hematopoietic cell transplant (HCT) patients are susceptible to both acute kidney injury (AKI) and chronic kidney disease (CKD). The etiologies of AKI vary but include tumor infiltration, radiation, drug-induced toxicity, and fluid and electrolyte abnormalities including tumor lysis syndrome. HCT patients can also have additional complications such as sinusoidal obstructive syndrome
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Isolated nocturnal hypertension is associated with increased left ventricular mass index in children Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Tomáš Seeman, Ondřej Hradský, Jiří Gilík
Background Isolated nocturnal hypertension (INH) is associated with increased prevalence of left ventricular hypertrophy (LVH) and cardiovascular morbidity and mortality in adult patients. Unlike in adults, data illustrating the possible association between INH and cardiac target organ damage is lacking in children. This study aimed to investigate whether INH is associated with increased left ventricular
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Sirtuins play critical and diverse roles in acute kidney injury Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Kevin Peasley, Takuto Chiba, Eric Goetzman, Sunder Sims-Lucas
Acute kidney injury (AKI) is an extremely common medical affliction affecting both adult and pediatric patients resulting from hypoxic, nephrotoxic, and septic insults affecting approximately 20% of all hospital patients and up to 50% of patients in the intensive care unit. There are currently no therapeutics for patients who suffer AKI. Much recent work has focused on designing and implementing therapeutics
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Low agreement between kidney volume and kidney length z-scores Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Laura Torres-Canchala, Martin Rengifo, Guido Filler, Juan C. Arias, Oscar Ramirez, Jaime M. Restrepo
Background Pediatric nephrologists use kidney length and kidney volume z-scores to longitudinally assess normal nephron endowment. However, most radiologists only report kidney length. Agreement between kidney length and kidney volume z-scores in children has been understudied. This study aims to assess agreement between kidney length and kidney volume z-scores in children. Methods This novel cross-sectional
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Acute kidney injury in children hospitalized for acute gastroenteritis: prevalence and risk factors Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Pierluigi Marzuillo, Maria Baldascino, Stefano Guarino, Silverio Perrotta, Emanuele Miraglia del Giudice, Felice Nunziata
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Acute kidney injury and aging Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-07 Monica Chang-Panesso
Our aging population is growing and developing treatments for age-related diseases such as Alzheimer’s and Parkinson’s disease has taken on an increasing urgency and is accompanied by high public awareness. The already high and rising incidence of acute kidney injury (AKI) in the elderly, however, has received relatively little attention despite the potentially fatal outcomes associated with an episode
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Monitoring dialysis adequacy: history and current practice Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-05 Linda Ding, James Johnston, Maury N. Pinsk
Dialysis adequacy for pediatric patients has largely followed the trends in adult dialysis by judging the success or adequacy of peritoneal or hemodialysis with urea kinetic modeling. While this provides a starting point to establish a dose of dialysis, it is clear that urea is only part of the picture. Many clinical parameters and interventions now have been identified that are just as impactful on
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Distribution of proteinuria- and albuminuria-to-creatinine ratios in preterm newborns Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-04 Laure Ponthier, Marine Trigolet, Thierry Chianea, Fabienne Mons, Catherine Yardin, Vincent Guigonis, Chahrazed El Hamel
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Acute peritoneal dialysis, complications and outcomes in 389 children with STEC-HUS: a multicenter experience Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-04 Paula A. Coccia, Flavia B. Ramírez, Angela D. C. Suárez, Laura F. Alconcher, Alejandro Balestracci, Laura A. García Chervo, Iliana Principi, Aída Vázquez, Viviana M. Ratto, María Celia Planells, Jorge Montero, Mariana Saurit, Maria Graciela Pérez Y Gutiérrez, María Celeste Puga, Elsa M. Isern, María Carolina Bettendorff, Marcela V. Boscardin, Marta Bazán, Mario A. Polischuk, Alejo De Sarrasqueta, Adriana
Background Management of acute kidney injury (AKI) in children with hemolytic uremic syndrome induced by a Shiga toxin-producing Escherichia coli infection (STEC-HUS) is supportive; however, 40 to 60% of cases need kidney replacement therapy (KRT). The aim of this study was to analyze procedure complications, especially peritonitis, and clinical outcomes in children with AKI secondary to STEC-HUS treated
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Neutrophil gelatinase-associated lipocalin for urinary tract infection and pyelonephritis: a systematic review Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-03 Kai Shaikh, Vinod Rajakumar, Victor A. Osio, Nader Shaikh
Background The sensitivity and specificity of the leukocyte esterase test are relatively low for a screening test for urinary tract infection (UTI). More accurate tests could reduce both overtreatment and missed cases. This study aimed to determine whether neutrophil gelatinase-associated lipocalin (NGAL) can replace leukocyte esterase in the diagnosis of UTI and/or whether NGAL accurately identifies
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Non-invasive continuous renal tissue oxygenation monitoring to identify preterm neonates at risk for acute kidney injury Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-03 Matthew W. Harer, Claudette O. Adegboro, Luke J. Richard, Ryan M. McAdams
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Effect of levocarnitine supplementation on myocardial strain in children with acute kidney injury receiving continuous kidney replacement therapy: a pilot study Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-03 Kristen Sgambat, Sarah Clauss, Asha Moudgil
Background Carnitine plays a key role in energy production in the myocardium and is efficiently removed by continuous kidney replacement therapy (CKRT). Effects of levocarnitine supplementation on myocardial function in children receiving CKRT have not been investigated. Methods This controlled pilot cohort study of 48 children investigated effects of levocarnitine supplementation on myocardial strain
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Biomarkers in pediatric glomerulonephritis and nephrotic syndrome Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-03 Gabriel Cara-Fuentes, William E. Smoyer
Glomerular diseases are often chronic or recurring and thus associated with a tremendous physical, psychological, and economic burden. Their etiologies are often unknown, and their pathogeneses are frequently poorly understood. The diagnoses and management of these diseases are therefore based on clinical features, traditional laboratory markers, and, often, kidney pathology. However, the clinical
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First-week urine beta-2 microglobulin levels in term healthy neonates Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-02 Shimrit Tzvi-Behr, Heftziba Ivgi, Yaacov Frishberg, Efrat Ben Shalom
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Glomerular involvement in children with H syndrome Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-02 Odeya David, Michael Geylis, Eyal Kristal, Galina Ling, Ruth Schreiber
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Dietary fibre intake is low in paediatric chronic kidney disease patients but its impact on levels of gut-derived uraemic toxins remains uncertain Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-02 Amina El Amouri, Evelien Snauwaert, Aurélie Foulon, Charlotte Vande Moortel, Maria Van Dyck, Koen Van Hoeck, Nathalie Godefroid, Griet Glorieux, Wim Van Biesen, Johan Vande Walle, Ann Raes, Sunny Eloot
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Tumor necrosis factor-alpha is associated with mineral bone disorder and growth impairment in children with chronic kidney disease Pediatr. Nephrol. (IF 2.676) Pub Date : 2021-01-02 Kelly Meza, Sharmi Biswas, Yuan-Shan Zhu, Anuradha Gajjar, Eduardo Perelstein, Juhi Kumar, Oleh Akchurin
Background Mineral and bone disorder (MBD) and growth impairment are common complications of pediatric chronic kidney disease (CKD). Chronic inflammation detrimentally affects bone health and statural growth in non-CKD settings, but the impact of inflammation on CKD-MBD and growth in pediatric CKD remains poorly understood. This study assessed associations between inflammatory cytokines with biomarkers
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Correction to: Efficacy and safety of an innovative prolonged-release combination drug in patients with distal renal tubular acidosis: an open-label comparative trial versus standard of care treatments Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-28 Aurélia Bertholet-Thomas, Catherine Guittet, Maria A. Manso-Silván, Arnaud Castang, Véronique Baudouin, Mathilde Cailliez, Massimo Di Maio, Olivia Gillion-Boyer, Emilija Golubovic, Jérôme Harambat, Alexandre Klein, Bertrand Knebelmann, François Nobili, Robert Novo, Ludmila Podracka, Gwenaëlle Roussey-Kesler, Christos Stylianou, Luc-André Granier
The published version of the article unfortunately contained a mistake.
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Effects of COVID-19 pandemic on pediatric kidney transplant in the United States Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-26 Olga Charnaya, Teresa Po-Yu Chiang, Richard Wang, Jennifer D. Motter, Brian J. Boyarsky, Elizabeth A. King, William A. Werbel, Christine M. Durand, Robin K. Avery, Dorry L. Segev, Allan B. Massie, Jacqueline M. Garonzik-Wang
Background In March 2020, COVID-19 infections began to rise exponentially in the USA, placing substantial burden on the healthcare system. As a result, there was a rapid change in transplant practices and policies, with cessation of most procedures. Our goal was to understand changes to pediatric kidney transplantation (KT) at the national level during the COVID-19 epidemic. Methods Using SRTR data
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Erythropoietin-stimulating agent-resistant vitamin B 6 deficiency anemia in a pediatric patient on hemodialysis Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-11-06 Kristie Searcy, Sarah Rainwater, Majed Jeroudi, Radhakrishna Baliga
Background Vitamin B6 is a rate-limiting coenzyme that plays an important role in the biosynthesis of heme and the incorporation of iron into protoporphyrin. Its deficiency is often seen in chronic kidney disease (CKD), particularly those requiring dialysis and following administration of erythropoietin-stimulating agent (ESA). Case- diagnosis/treatment A 16-year-old African-American male with stage
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Prophylactic rituximab administration in children with complicated nephrotic syndrome Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-30 Mika Okutsu, Koichi Kamei, Mai Sato, Toru Kanamori, Kentaro Nishi, Sho Ishiwa, Masao Ogura, Mayumi Sako, Shuichi Ito, Kenji Ishikura
Background Rituximab is effective for maintaining remission in patients with complicated nephrotic syndrome, although a history of steroid-resistant nephrotic syndrome (SRNS) is a risk factor for early relapse. We investigated the efficacy of prophylactic rituximab treatment for maintaining remission after B cell recovery. Methods Patients with complicated steroid-dependent or frequently relapsing
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Evolution of bone mineral density in patients with idiopathic hypercalciuria: a 20-year longitudinal study. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-26 German Perez-Suarez,Ma Isabel Luis Yanes,Maria Cecilia Martín Fernández de Basoa,Elena Sánchez Almeida,Víctor M García Nieto
BACKGROUND Several recent studies reported bone mineral density (BMD) reduction in pediatric patients with idiopathic hypercalciuria (IH). This longitudinal study aimed to evaluate BMD evolution in IH patients through three bone densitometry studies conducted over 20 years on average. A second objective was to evaluate urine calcium and citrate excretion during this period. METHODS Case notes of 34
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The current status of kidney transplantation in Nigerian children: still awaiting light at the end of the tunnel. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-24 Felicia U Eke,Taiwo A Ladapo,Augustina N Okpere,Olalekan Olatise,Ifeoma Anochie,Tochi Uchenwa,Henrietta Okafor,Paul Ibitoye,Uchenna Ononiwu,Ademola Adebowale,Rosamund Akuse,Seyi Oniyangi
BACKGROUND Kidney transplantation (KT) is the gold standard treatment for children with chronic kidney disease stage 5 (CKD5). It is easily accessible in well-resourced countries, but not in low/middle-income countries (LMICs). We present, a multicentre experience of paediatric KT of children domiciled in Nigeria. We aim to highlight the challenges and ethical dilemmas that children, their parents
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Policy in pediatric nephrology: successes, failures, and the impact on disparities. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-23 Jill R Krissberg,Scott M Sutherland,Lisa J Chamberlain,Paul H Wise
Pediatric nephrology has a history rooted in pediatric advocacy and has made numerous contributions to child health policy affecting pediatric kidney diseases. Despite this progress, profound social disparities remain for marginalized and socially vulnerable children with kidney disease. Different risk factors, such as genetic predisposition, environmental factors, social risk factors, or health care
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Is there a new method for determining aortic root dilatation in children? Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-23 Ahmet Sert
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Baseline characteristics and long-term outcomes of steroid-resistant nephrotic syndrome in children: impact of initial kidney histology. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-22 Yoshitaka Watanabe,Shuichiro Fujinaga,Amane Endo,Shota Endo,Mayu Nakagawa,Koji Sakuraya
BACKGROUND Although many pediatric nephrologists consider focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) as separate clinical entities, whether the initial histology could affect clinical courses in children with steroid-resistant nephrotic syndrome (SRNS) suspected of having an immune-based etiology remains unknown, especially for long-term outcomes. METHODS We retrospectively
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Correction to: C3 levels and neurologic involvement in hemolytic uremic syndrome related to Shiga toxin-producing Escherichia coli. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-08-23 Alejandro Balestracci,Luciana Meni Battaglia
The original version of the letter unfortunately contained a mistake.
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Therapeutic plasma exchange: single-center experience in children with kidney disorders. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-19 Catherine Joseph,Sahar Siddiqui,Shweta Shah,Catharina H Solomon,Poyyapakkam R Srivaths
BACKGROUND Therapeutic plasma exchange (TPE) is used in kidney diseases as an adjunct treatment. Little has been described as to its effectiveness in kidney disorders in children. This study aimed to assess the safety, efficacy, and outcomes of patients who underwent TPE for kidney indications. METHODS Retrospective chart review of patients receiving TPE from 2010 to 2018 for kidney indications, such
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Characterizing dynamics of serum creatinine and creatinine clearance in extremely low birth weight neonates during the first 6 weeks of life. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-17 Tamara van Donge,Karel Allegaert,Verena Gotta,Anne Smits,Elena Levtchenko,Djalila Mekahli,John van den Anker,Marc Pfister
Background Characterizing the dynamics of serum creatinine concentrations (Scr) and associated creatinine clearance (CLcr) as a measure of kidney function in extremely low birth weight (≤ 1000 g; ELBW) neonates remains challenging. Methods We performed a retrospective study that included longitudinal Scr (enzymatic assay) data from 148 ELBW neonates up to 6 weeks after birth. Change of Scr and inter-individual
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Comparing predictive values of carbohydrate antigen 19-9, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 in 161 patients with ureteropelvic junction obstruction. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-16 Kiarad Fendereski,Amirreza Nabighadim,Maryam Seyedtabib,Seyedeh Sima Daryabari,Mohammad Taghi Haghi-Ashtiani,Abdol-Mohammad Kajbafzadeh
Background To evaluate and compare the efficacy of urinary carbohydrate antigen 19-9 (CA19-9), neutrophil gelatinase–associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) biomarkers as predictive factors to determine the surgery requirement in patients with ureteropelvic junction obstruction. Methods We obtained urine samples from 161 patients at diagnosis and evaluated their levels of
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Pediatric kidney transplantation in China: an analysis from the IPNA Global Kidney Replacement Therapy Registry. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-15 Qian Shen,Xiaoyan Fang,Xinyue Man,Yihui Zhai,Longshan Liu,Changxi Wang,Wenjun Shang,Guiwen Feng,Lei Zhang,Li Zeng,Youhua Zhu,Jing Chen,Jia Rao,Bradley A Warady,Franz Schaefer,Hong Xu
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Urine collection methods and dipstick testing in non-toilet-trained children. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-12 James Diviney,Mervyn S Jaswon
Urinary tract infection is a commonly occurring paediatric infection associated with significant morbidity. Diagnosis is challenging as symptoms are non-specific and definitive diagnosis requires an uncontaminated urine sample to be obtained. Common techniques for sampling in non-toilet-trained children include clean catch, bag, pad, in-out catheterisation and suprapubic aspiration. The pros and cons
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Resident foreign patients receive adequate dialysis but fewer preemptive transplantations: data from the Italian pediatric dialysis registry. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-10 Fabio Paglialonga,Silvia Consolo,Enrico Vidal,Mattia Parolin,Bruno Minale,Mario Giordano,Isabella Guzzo,Chiara Benevenuta,Rosa Roperto,Ciro Corrado,Francesca Mencarelli,Roberto Chimenz,Ilse-Maria Ratsch,Giovanni Pieri,Giovanni Montini,Alberto Edefonti,Enrico Verrina
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Adherence to cysteamine in nephropathic cystinosis: A unique electronic monitoring experience for a better understanding. A prospective cohort study: CrYSTobs. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-09 Segolene Gaillard,Laurent Roche,Sandrine Lemoine,Georges Deschênes,Denis Morin,Christine Vianey-Saban,Cécile Acquaviva-Bourdain,Bruno Ranchin,Justine Bacchetta,Behrouz Kassai,Patrice Nony,Eurielle Bodénan,Valérie Laudy,Cécile Rouges,Setareh Zarrabian,Fabien Subtil,Catherine Mercier,Pierre Cochat,Aurélia Bertholet-Thomas
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Pathophysiology and consequences of arterial stiffness in children with chronic kidney disease. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-07 Karolis Azukaitis,Augustina Jankauskiene,Franz Schaefer,Rukshana Shroff
Changes in arterial structure and function are seen early in the course of chronic kidney disease (CKD) and have been causally associated with cardiovascular (CV) morbidity. Numerous potential injuries encompassing both traditional and uremia-specific CV risk factors can induce structural arterial changes and accelerate arterial stiffening. When the buffering capacity of the normally elastic arteries
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Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-05 Eun Mi Yang,Kee Hwan Yoo,Yo Han Ahn,Seong Heon Kim,Jung Won Lee,Woo Yeong Chung,Min Hyun Cho,Kee Hyuck Kim,Heeyeon Cho,Mee Jeong Lee,Jin-Soon Suh,Hye Sun Hyun,Jiwon M Lee,Myung Hyun Cho,Ji Hyun Kim,Il-Soo Ha,Hae Il Cheong,Hee Gyung Kang
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Therapy and outcomes of C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-04 Priyanka Khandelwal,Swati Bhardwaj,Geetika Singh,Aditi Sinha,Pankaj Hari,Arvind Bagga
Background Data on therapy and outcome of dense deposit disease (DDD), C3 glomerulonephritis (C3GN), and immune-complex MPGN (IC-MPGN) in children are limited. Methods In this retrospective single-center study from 2007 to 2019, kidney biopsies were reviewed to include patients aged <18-years with C3 glomerulopathy and IC-MPGN. Initial immunosuppression comprised prednisolone, mycophenolate mofetil
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Bilateral native nephrectomies for severe hypertension in children with stage 5 chronic kidney disease leads to improved BP control following transplantation. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-03 Charles Pickles,Amrit Kaur,Dean Wallace,Christian Brix,Rachel Lennon,Nicholas Plant,Mohan Shenoy
Background Hypertension is a common problem in stage 5 chronic kidney disease (CKD 5) and following kidney transplantation (KT). There is limited data on the outcome of children with CKD 5 who undergo bilateral native nephrectomies (BNN) for the management of hypertension. Method Retrospective review of 134 children who underwent KT at a single centre over a 10-year period and had a minimum follow
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Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-03 Lieke A Hoogenboom,Tim G A M Wolfs,Matthias C Hütten,Carine J Peutz-Kootstra,Michiel F Schreuder
Prematurity and perinatal stress, such as intrauterine growth restriction (IUGR) and chorioamnionitis, are pathological processes creating an impaired intrauterine environment. These intrauterine factors are associated with the development of proteinuria, hypertension, and chronic kidney disease (CKD) later in life. Initially, this was thought to be secondary to oligonephropathy, subsequent glomerular
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Evolution of isolated systolic hypertension with normal central blood pressure in adolescents-prospective study. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-03 Łukasz Obrycki,Janusz Feber,Grażyna Brzezińska,Mieczysław Litwin
Background The clinical significance of isolated systolic hypertension with normal central blood pressure known as spurious hypertension (sHT) in adolescents and its evolution over time is not known. Methods The aim of this study was to analyze changes in office, ambulatory blood pressure (ABPM), central systolic blood pressure (cSBP), hemodynamic parameters, and target organ damage (TOD) over a 1-year
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Transforming growth factor beta signaling functions during mammalian kidney development. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-03 Mihai G Dumbrava,Jon L Lacanlale,Christopher J Rowan,Norman D Rosenblum
Aberrant transforming growth factor beta (TGFβ) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGFβ signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGFβ signaling during kidney development
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Cystic dysplasia of the kidneys in extremely preterm infants following acute kidney injury. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-01 Seh Hyun Kim,Yo Han Ahn,Jeongmin Shin,Young Hwa Jung,Ji Young Kim,Chang Won Choi
Background Various perinatal morbidities may adversely affect postnatal nephrogenesis in preterm infants. Kidney ultrasonographic findings following acute kidney injury (AKI) have not been well described in preterm infants. Herein, we describe three cases of extremely preterm infants who showed abnormal kidney ultrasonographic findings resembling dysplasia of the kidneys following AKI. Case-diagnosis/treatment
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Steroid treatment promotes an M2 anti-inflammatory macrophage phenotype in childhood lupus nephritis. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-01 Yohei Ikezumi,Tomomi Kondoh,Yuji Matsumoto,Naonori Kumagai,Masahiro Kaneko,Hiroya Hasegawa,Takeshi Yamada,Utako Kaneko,David J Nikolic-Paterson
Background M1-type proinflammatory macrophages (MΦ) promote glomerular injury in lupus nephritis (LN). However, whether this phenotype is altered by steroid therapy is unclear. Therefore, we investigated the effect of steroid treatment on MΦ phenotype in LN. Methods Patients with LN (7–18 years old) were divided into 2 groups: those with no treatment (N) before biopsy (n = 17) and those who underwent
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Taking a multidisciplinary approach to maintaining haemodialysis vascular access: a challenging case in an infant: Questions. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-01 Rebecca Anderson,Brendan Cusack,Elhamy Bekhit,Bernadita Troncoso Solar,Cathy Quinlan,Joshua Kausman
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Taking a multidisciplinary approach to maintaining haemodialysis vascular access: a challenging case in an infant: Answers. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-09-01 Rebecca Anderson,Brendan Cusack,Elhamy Bekhit,Bernadita Troncoso Solar,Cathy Quinlan,Joshua Kausman
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COVID-19 associated with onset nephrotic syndrome in a pediatric patient: coincidence or related conditions? Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-08-27 Amado Alvarado,Gabriela Franceschi,Evelin Resplandor,Jeannethe Sumba,Nelson Orta
Background COVID-19 is less frequent in children than in adults and affects the former less severely; despite the fact that respiratory symptoms are the most frequent, in some cases unusual manifestations can be seen. Case-diagnosis We present a 15-year-old boy who tested positive for SARS-COV-2 infection and onset of nephrotic syndrome, without antecedent of kidney disease and who had normal urine
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Mycophenolic acid area under the concentration-time curve is associated with therapeutic response in childhood-onset lupus nephritis. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-08-27 Astrid Godron-Dubrasquet,Jean-Baptiste Woillard,Stéphane Decramer,Marc Fila,Vincent Guigonis,Stéphanie Tellier,Denis Morin,Maud Sordet,Frank Saint-Marcoux,Jérôme Harambat
BACKGROUND Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is widely used in lupus nephritis treatment. Therapeutic drug monitoring of adults suggests that area under the concentration-time curve (AUC) of MPA (MPA-AUC) is associated with clinical outcomes, but childhood data are scarce. METHODS Retrospective study of 27 children with biopsy-proven lupus nephritis treated
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Be aware of acute kidney injury in critically ill children with COVID-19. Pediatr. Nephrol. (IF 2.676) Pub Date : 2020-08-26