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Characterization of extracellular trap production and release by equine neutrophils in response to different stimuli Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-28 John Quiroga, Bayron Cortes, José Sarmiento, Gabriel Morán, Claudio Henríquez
This study explores Neutrophil Extracellular Trap (NET) formation in equine neutrophils, which is crucial for eliminating infections and is implicated in various equine inflammatory diseases. We investigated the molecular pathways involved in NET release by equine neutrophils in response to stimuli. We use PMA, A23187, LPS, PAF, OZ, and cytokines, observing NET release in response to PMA, PAF, and
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The cytokine genes of Oncorhynchus masou formosanus include a defective interleukin-4/13A gene Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-28 Ying-Hsuan Yen, De Yu Zheng, Shu Yuan Yang, Jin-Chywan Gwo, Sebastian D. Fugmann
(Formosa landlocked salmon) is a critically endangered salmonid fish endemic to Taiwan. To begin to understand how its drastic change in lifestyle from anadromous to exclusively river-dwelling is reflected in its immune genes, we characterized the genes encoding six cytokines (IL-2A, IL-2B, IL-4/13A, IL-4/13B1, IL-4/13B2, and IL-17A/F2a) important for T cell responses as no genomic data is available
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The interactions between CpG oligodeoxynucleotides and Toll-like receptors in Pacific white shrimp Litopenaeus vannamei Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-27 Xuerui Gong, Feng Hu, Jingjie Hu, Zhenmin Bao, Mengqiang Wang
CpG oligodeoxynucleotides (ODNs), as a novel type of adjuvant with immunomodulatory effects, are recognized by Toll-like receptors (TLRs) in . In the present study, eleven TLRs-pCMV recombinants (rTLRs) were constructed to investigate the relationships between various CpG ODNs and different TLRs in human embryonic kidney 293T (HEK293T) cells, which was further confirmed by bio-layer interferometry
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Interferon regulatory factors inhibit TiLV replication by activating interferon-a3 in tilapia (Oreochromis niloticus) Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-24 Zishan Ke, Jing Wen, Yingying Wang, Bo Li, Siyu Wu, Defeng Zhang, Xubing Mo, Yingying Li, Yan Ren, Jiyuan Yin, Cunbin Shi, Shucheng Zheng, Qing Wang
Tilapia lake virus (TiLV) is an emerging virus that seriously threatens the tilapia industries worldwide. Interferon regulatory factors (IRFs), which are the crucial mediators regulating the response of interferon (IFN) to combat invading viruses, have not yet been reported in tilapia during TiLV infection. Here, six IRF (IRF1, IRF2, IRF4, IRF7, IRF8, and IRF9) homologs from tilapia were characterized
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Transcriptional profiling of Bulinus globosus provides insights into immune gene families in snails supporting the transmission of urogenital schistosomiasis Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-15 Lijing Bu, Mohamed R. Habib, Lijun Lu, Martin W. Mutuku, Eric S. Loker, Si-Ming Zhang
Schistosomiasis, urogenital and intestinal, afflicts 251 million people worldwide with approximately two-thirds of the patients suffering from the urogenital form of the disease. Freshwater snails of the genus (Gastropoda: Planorbidae) serve as obligate intermediate hosts for , the etiologic agent of human urogenital schistosomiasis. These snails also act as vectors for the transmission of schistosomiasis
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Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-09 Takahiko Hata, Hidetoshi Shimawaki, Suzuka Setoguchi, Natsuki Morimoto, Jun-ichi Hikima, Masahiro Sakai, Tomoya Kono
Several immune-related genes, including Toll-like receptors (TLR), are associated with circadian rhythms in mammals. However, information on the circadian rhythmic expression of TLRs in fish is limited. In this study, we aimed to analyze the regulation of diel oscillations in the expression of TLR genes in Japanese medaka (). The expression analysis revealed diel expression patterns of , , , and clock
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A family of olfactory receptors uniquely expanded in marsupial and monotreme genomes are expressed by a T cell subset also unique to marsupials and monotremes Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-08 Jordan M. Sampson, Kimberly A. Morrissey, Daniel C. Douek, Robert D. Miller
Olfactory receptors (OR), expressed on olfactory neurons, mediate the sense of smell. Recently, OR have also been shown to be expressed in non-olfactory tissues, including cells of the immune system. An analysis of single-cell transcriptomes of splenocytes of the grey short-tailed opossum () found OR are expressed on a subset of T cells, the γμ T cells, that are unique to marsupials and monotremes
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Natural selection directing molecular evolution in vertebrate viral sensors Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-06 Balraj Melepat, Tao Li, Michal Vinkler
Diseases caused by pathogens contribute to molecular adaptations in host immunity. Variety of viral pathogens challenging animal immunity can drive positive selection diversifying receptors recognising the infections. However, whether distinct virus sensing systems differ across animals in their evolutionary modes remains unclear. Our review provides a comparative overview of natural selection shaping
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Caenorhabditis elegans immune responses to microsporidia and viruses Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-06 Rubén González, Marie-Anne Félix
The model organism is susceptible to infection by obligate intracellular pathogens, specifically microsporidia and viruses. These intracellular pathogens infect intestinal cells, or, for some microsporidia, epidermal cells. Strikingly, intestinal cell infections by viruses or microsporidia trigger a common transcriptional response, activated in part by the ZIP-1 transcription factor. Among the strongest
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Cleavage of gasdermin by apoptotic caspases triggers pyroptosis restricting bacterial colonization in Hydra Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-05 Shuxin Li, Xiaoyang Lu, Xiuqing lin, Yuanxing Zhang, Qin Liu, Shouwen Chen
Gasdermin (GSDM) proteins, as the direct executors of pyroptosis, are structurally and functionally conserved among vertebrates and play crucial roles in host defense against infection, inflammation, and cancer. However, the origin of functional GSDMs remains elusive in the animal kingdom. Here, we found that functional GSDME homologs first appeared in the cnidarian. Moreover, these animal GSDME homologs
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Characterization of the antibacterial and opsonic functions of the antimicrobial peptide LvCrustinVI from Litopenaeus vannamei Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-04 Jie Hu, Shihao Li, Miao Miao, Fuhua Li
Microbial drug resistance is becoming increasingly severe due to antibiotic abuse. The development and utilization of antimicrobial peptides is one of the important ways to solve this difficult problem. Crustins are a family of antimicrobial peptides that play important roles in the innate immune system of crustaceans. Several types of crustins exist in shrimp and their activities vary greatly. In
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The effects of four paralogous piscidin antimicrobial peptides on the chemotaxis, macrophage respiratory burst, phagocytosis and expression of immune-related genes in orange-spotted grouper (Epinephelus coicodes) Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-03 Xiazi Huang, Wei Mao, Yonghao Yi, Yubin Lu, Feihong Liu, Li Deng
Antimicrobial peptides (AMPs) are an essential part of the vertebrate innate immune system. Piscidins are a family of AMPs specific in fish. In our previous investigation, we identified four paralogous genes of piscidins in the orange-spotted grouper (), which exhibited distinct activities against bacteria, fungi, and parasitic ciliated protozoa. Piscidins demonstrated their capability to modulate
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Effects on viral suppression and the early-immune expression of ribavirin against spring viremia of carp virus in vitro Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-03 Eun Jin Baek, Ye Jin Jeong, Guk Hyun Kim, Min Jae Kim, Kwang Il Kim
Spring viremia of carp virus (SVCV) is a globally distributed virus that causes severe clinical symptoms and high mortality in fish belonging to the families and . To protect the host against viral infection, understanding the relatedness between viral susceptibility and antiviral mechanisms must be crucial. Thus, we evaluated the viral suppression efficacy of ribavirin by measuring the transcription
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SfMBP: A novel microbial binding protein and pattern recognition receptor in the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae) Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-02-02 Bang-Xian Zhang, Fang-Fang Liu, Feng Liu, Wen-Xuan Qi, Yan-Qin Si, Hai-Yan Ren, Xiang-Jun Rao
The fall armyworm, , poses a significant threat as a highly destructive agricultural pest in many countries. Understanding the complex interplay between the insect immune system and entomopathogens is critical for optimizing biopesticide efficacy. In this study, we identified a novel microbial binding protein, SfMBP, in . However, the specific role of SfMBP in the immune response of remains elusive
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Klebsiella aerogenes ingestion elicits behavioral changes and innate immunity in the host, Caenorhabditis elegans Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-27 Thirumugam Gowripriya, Radhakrishnan Yashwanth, Bhaskar James Prabhanand, Ramamurthi Suresh, Krishnaswamy Balamurugan
Klebsiella aerogenes (previously known as Enterobacter aerogenes) is a common opportunistic pathogen that infect the respiratory tract and central nervous system. However, how it interferes the host regulatory mechanism has not been previously described. When C. elegans were exposed to K. aerogenes, they exhibited a shorter lifespan compared to those fed with E. coli OP50. The time required for 50 %
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Aeromonas veronii tolC modulates its virulence and the immune response of freshwater pearl mussels, Hyriopsis cumingii Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-14 Sichun Zheng, Xiaoqi Tang, Qinglin Yang, Xicheng Zhou, Yanhong Li, Zhengli Wu
Aeromonas veronii is an opportunistic pathogen that causes diseases in aquatic animals, but its key virulence factors remain unclear. We screened the gene tolC with significantly different expression levels in the two isolates, A. veronii GL2 (higher virulence) and A. veronii FO1 (lower virulence). Therefore, we constructed mutant strain ΔtolC and analyzed its immunological properties. ΔtolC exhibited
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In Memoriam: Bradley Gregg Magor, 1960–2023 Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-12
Abstract not available
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Prokaryotic and eukaryotic dual-expression plasmid-mediated delivery of Campylobacter jejuni antigens by live-attenuated Salmonella: A strategy for concurrent Th1 and Th2 immune activation and protection in chickens Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-06 Sivasankar Chandran, Chamith Hewawaduge, Ram Prasad Aganja, John Hwa Lee
Salmonella and Campylobacter are food-borne pathogens that significantly affect poultry production and are transmitted to humans. Long-term protection against these pathogens in chicken relies on a balanced Th1 and Th2 response. C. jejuni antigens were screened and a fusion antigen, including CadF + FlaA adhesin and flagellin antigenic fragments was developed and safely delivered by low-endotoxicity
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A single coelomic cell type is involved in both immune and respiratory functions of the coastal bioindicator annelid: Capitella C-Channel1 from the English Channel Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-04 Céline Boidin-Wichlacz, Ann C. Andersen, Nathalie Jouy, Stéphane Hourdez, Aurélie Tasiemski
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The effects of primary and secondary bacterial exposure on the seahorse (Hippocampus erectus) immune response Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-05 Jamie Parker, Silke-Mareike Marten, Tadhg C. Ó Corcora, Jelena Rajkov, Arseny Dubin, Olivia Roth
Evolutionary adaptations in the Syngnathidae teleost family (seahorses, pipefish and seadragons) culminated in an array of spectacular morphologies, key immune gene losses, and the enigmatic male pregnancy. In seahorses, genome modifications associated with immunoglobulins, complement, and major histocompatibility complex (MHC II) pathway components raise questions concerning their immunological efficiency
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Uncovering the antimicrobial activity of G-type lysozyme 2 derived from Cyprinus carpio mucus against bacterial and fungal pathogens Dev. Comp. Immunol. (IF 2.9) Pub Date : 2024-01-05 Uzma Shabir, Jehangir Shafi Dar, Aashaq Hussain Bhat, Bashir Ahmad Ganai, Mohamed H. Mahmoud, Gaber El-Saber Batiha
This study aimed to explore the antimicrobic potential of mucus samples collected from Cyprinus carpio and identify the specific antimicrobial peptides responsible for its activity. The crude extract was tested against various bacterial and fungal pathogens, and its protein content and profile were analyzed. Purification steps, including gel filtration chromatography, were employed to isolate the most
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Transcriptomic profiling and the first spatial expression analysis of candidate genes in the salivary gland of the East Asian medicinal leech, Hirudo nipponia Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-28 Jung-Hyeuk Kim, Chan-Jun Lee, Yun-Sang Yu, Yam Prasad Aryal, Sangil Kim, Jo-Young Suh, Jae-Young Kim, Sun Hong Min, In-Tae Cha, Hae-Youn Lee, Song Yub Shin, Sung-Jin Cho
Hirudo nipponia, a blood-sucking leech native to East Asia, possesses a rich repertoire of active ingredients in its saliva, showcasing significant medical potential due to its anticoagulant, anti-inflammatory, and antibacterial effects against human diseases. Despite previous studies on the transcriptomic and proteomic characteristics of leech saliva, which have identified medicinal compounds, our
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PyLKB1 regulates glucose transport via activating PyAMPKα in Yesso Scallop Patinopecten yessoensis under high temperature stress Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-30 Dongli Jiang, Chuanyan Yang, Wenfei Gu, Xiaoxue Ma, Ziling Tong, Lingling Wang, Linsheng Song
Liver kinase B1 (LKB1) is a classical serine/threonine protein kinase and plays an important role in maintaining energy homeostasis through phosphorylate AMP-activated protein kinase α subunit (AMPKα). In this study, a homologous molecule of LKB1 with a typical serine/threonine kinase domain and two nuclear localization sequences (NLSs) was identified in Yesso Scallop Patinopecten yessoensis (PyLKB1)
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Structural and pharmacological characterization of a medium-chain fatty acid receptor GPR84 in common carp (Cyprinus carpio) Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-29 Ming-Xing Yao, Hui-Xia Yu, Hao-Lin Mo, Zhi-Hao Zhang, Qing-Chuan Song, Qiao Liu, Qi-Yuan Yang, Li-Xin Wang, Yang Li
The medium-chain fatty acid receptor GPR84, a member of the G protein-coupled receptor family, is mainly expressed in macrophages and microglia, and is involved in the regulation of inflammatory responses and retinal development in mammals and amphibians. However, structure, tissue distribution, and pharmacology of this receptor have rarely been reported in fish. In this study, we cloned the coding
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HIF-1-mediated regulation of LDH gene unravels key insights into MCDV-1 pathogenesis in mud crabs Scylla paramamosain Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-29 Yu-Kun Jie, Jia-Wei Xie, Chang-Hong Cheng, Jian-Jun Jiang, Hong-Ling Ma, Guang-Xin Liu, Si-Gang Fan, Yi-Qin Deng, Juan Feng, Zhi-Xun Guo
Hypoxia-inducible factors −1 (HIF-1) is a crucial transcription factor that regulates the expression of glycolytic genes. Our previous study proved that the Mud crab dicistrovirus-1 (MCDV-1) can induce aerobic glycolysis that favors viral replication in mud crab Scylla paramamosain. However, the role of HIF-1 on key glycolytic genes during the MCDV-1 infection has not been examined. In this study,
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Identification of the NOD-like receptor family of golden pompano and expression in response to bacterial and parasitic exposure reveal its key role in innate immunity Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-20 Jin-Min Pan, Yu Liang, Ke-Cheng Zhu, Hua-Yang Guo, Bao-Suo Liu, Nan Zhang, Dian-Chang Zhang
This study presents a genome-wide identification of NOD-like receptors (NLRs) in the golden pompano, key to its innate immunity. We identified 30 ToNLRs, analyzing their chromosomal positions, characteristics, evolutionary relationships, evidence of positive selection, and synteny with the yellowtail kingfish. Our findings categorize these NLRs into three main subgroups: NLRA, NLRC, and the distinct
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Cytotoxic activity and gene expression during in vitro adaptive cell-mediated cytotoxicity of head-kidney cells from betanodavirus-infected European sea bass Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-23 Miguel A. García-Álvarez, Elena Chaves-Pozo, Alberto Cuesta
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Counteracting immunotyrosine-based signaling motifs augment zebrafish leukocyte immune-type receptor-mediated phagocytic activity Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-20 Rikus R. Niemand, James L. Stafford
Leukocyte immune-type receptors (LITRs) represent a polymorphic and polygenic family of immunoregulatory proteins originally discovered in channel catfish (Ictalurus punctatus; IpLITRs). Belonging to the immunoglobulin superfamily (IgSF), IpLITRs are generally classified as stimulatory or inhibitory types based on their utilization of various intracellular tyrosine-based signaling motifs. While research
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Animal granulins: In the GRN scheme of things Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-13 Christina R. Bowhay, Patrick C. Hanington
Granulins are conserved in nearly all metazoans, with an intriguing loss in insects. These pleiotropic peptides are involved in numerous physiological and pathological processes yet have been overwhelmingly examined in mammalian systems. While work in other animal models has been informative, a richer understanding of the proteins should be obtained by integrating knowledge from all available contexts
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Low-dose of formalin-inactivated Vibrio alginolyticus protects Crassostrea gigas from secondary infection and confers broad-spectrum Vibrio resistance on offspring Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-16 Hebing Wang, Ben Yang, Qi Li, Shikai Liu
An increasing number of evidences have shown that invertebrate taxa can be primed to produce immune memory to resist the secondary infection of pathogens, which was considered as a viable option to protect invertebrates from pathogens. In this work, we compared the protective effect of several different immune priming methods on the Vibrio alginolyticus secondary infection of the Crassostrea gigas
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Evolutionarily conserved IL-22 participates in gut mucosal barrier through its receptors IL-22BP, IL-10R2 and IL-22RA1 during bacterial infection in teleost Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-09 Qiongyao Zeng, Xiaofeng Liu, Yiyang Tang, Zhengwei Li, Ye Yang, Niewen Hu, Qingfeng Liu, Zejun Zhou
IL-22 is a critical cytokine of epithelial mucosal barrier. In humans, IL-22 signals through a heteroduplex receptor consisting of IL-22R and IL-10Rβ. In fish, IL-22 and its receptors homologues have been cloned in a number of species, however, no studies have been reported how the receptors are involved in IL-22 transduction. For this purpose, in this study we identified IL-22 and its soluble receptor
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Dual oxidase 2 (duox 2) participates in the intestinal antibacterial innate immune responses of Procambarus clarkii by regulating ROS levels Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-13 Qianqian Li, Mingda Zhang, Shiyu Qin, Jing Wen, Xiuli Shen, Zhiqiang Du
Dual oxidase (Duox) a member of the nicotinamide adenine dinucleotide phosphate oxidase (NOX) family can induce the production of reactive oxygen species (ROS). In vertebrates, the duox gene was indicated to be associated with the mucosal immunity. The roles of the duox gene in invertebrates were mainly studied in insects for the function of maintaining intestinal flora balance. In recent years, some
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Ras3 in Bombyx mori with antiviral function against B. mori nucleopolyhedrovirus Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-13 Dingguo Xia, Dan Jiang, Pengcheng Yu, Kaifang Jia, Jinyang Wang, Dongxu Shen, Qiaoling Zhao, Cheng Lu
Bombyx mori ras protein3 (BmRas3) is a small molecular protein in the GTPase superfamily, which has the activity of binding guanosine nucleotides and GTP enzymes. It acts as a molecular switch by coupling extracellular signal to different cellular response through the conversion between Ras-GTP conformation and Ras-GDP conformation, thus regulating signal pathways responsible for cell growth, migration
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Innate immunity response of zafirlukast treated-tilapia during foreign body inflammation Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-12 Susana Luporini de Oliveira, Camila Carlino da Costa, Mayumi Fernanda Aracati, Leticia Franchin Rodrigues, Gabriel Conde, Alessandra Cristina de Moraes, Annelise Carla Camplesi, Thais Heloisa Vaz Farias, Ives Charlie Silva, Luiz Arthur Malta Pereira, Marco Antonio de Andrade Belo
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Comparison of skin mucus lectins among longtooth grouper Epinephelus bruneus and giant grouper E. lanceolatus as well as the hybrid, Kue-Tama, and their binding abilities to the skin fluke Benedenia epinepheli Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-10 Mai Sakakibara, Ryuichiro Aoki, Shukei Masuma, Osamu Nakamura, Sho Shirakashi, Shigeyuki Tsutsui
Interspecific hybrids of farm-raised fish are becoming popular in aquaculture owing to their advantages over pure species, including improved growth and higher resistance to infectious diseases. Kue-Tama is a recently established hybrid grouper derived from the longtooth grouper Epinephelus bruneus (♀) × giant grouper E. lanceolatus (♂). In our previous study, this hybrid showed significantly higher
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Molecular characterization and antimicrobial activity of cecropin family in Hermetia illucens Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-09 Jian Peng, Lu Li, Yan Wan, Yifan Yang, Xiaoqin An, Kexin Yuan, Zhilang Qiu, Yinhui Jiang, Guo Guo, Feng Shen, Guiyou Liang
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Identification and structural analysis of dimeric chicken complement component 3d and its binding with chicken complement receptor 2 Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-12-05 Huan Jin, Min Tu, Zhaoying Meng, Bo Jiang, Qianqian Yang, Yongqing Li, Zhenhua Zhang
Complement component 3d (C3d), the final cleavage product of complement component C3, interacts with CR2 and thus plays a crucial role in linking the innate and adaptive immune systems. Additionally, human C3d executes various functions in its dimeric form, which is more effective than its monomeric form. In this study, we aimed to explored whether chicken C3d (chC3d) exhibits similar characteristics
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Short peptidoglycan recognition protein 5 modulates immune response to bacteria in Indian major carp, Cirrhinus mrigala Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-29 Zahoor Mushtaq, Pani Prasad Kurcheti, K. Jeena, P. Gireesh-Babu
Peptidoglycan recognition proteins (PGRPs) function in host antibacterial responses by recognizing bacterial peptidoglycan (PGN). In the present study, a short pgrp5 (named mpgrp5) was identified in Cirrhinus mrigala (mrigal). The full-length cDNA of the mpgrp5 gene was 1255 bp, containing an open reading frame of 746 bp encoding a protein of 248 amino acids. The predicted protein contained the typical
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Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-29 Lang Xie, Yixi Tao, Ziwei Shen, Huatang Deng, Xinbin Duan, Yang Xue, Daqing Chen, Yun Li
The spleen is postulated to be a hematopoietic tissue in adult fish; however, clear evidence is still lacking to define its role in hematopoietic activity. In our previous study, a congenitally asplenic zebrafish was generated though gene editing, which provided a new perspective for studying the role of fish spleen in hematopoiesis. In this study, HSC-regulated and erythrocyte marker genes, such as
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DNase I rescues goat sperm entrapped by neutrophil extracellular traps Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-28 Zhengkai Wei, Hongrong Hong, Wei Liu, Liqiang Jiang, Jingnan Xu, Xinxin Gao, Yuxiao Qian, Yuqian Jiang, Zha Jin, Qinqin Jin, Meiyi Chen, Zhengtao Yang
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Molecular cloning and functional characterization of pigeon IKKε Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-22 Peng Zhou, Aixin Liu, Dong Chen, Wanrong Wu, Qingxiang Zhang, Huanchun Chen, Hongbo Zhou, Rui Luo
Inhibitor of nuclear factor kappa-B kinase ε (IKKε), a member of the non-canonical IκB kinase family, plays a critical role in connecting various signaling pathways associated with the initiation of type I interferon (IFN) production. Although the importance of IKKε in innate immunity has been well established in mammals and fish, its characterization and function in pigeons have remained largely unexplored
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The identification of regulatory ceRNA network involved in Drosophila Toll immune responses Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-25 Yu Huang, Yujia Pang, Yina Xu, Li Liu, Hongjian Zhou
Non-coding RNAs play important roles in the innate immunity of Drosophila, with various lncRNAs and miRNAs identified to maintain Drosophila innate immune homeostasis by regulating protein functions. However, it remains unclear whether interactions between lncRNAs and miRNAs give rise to a ceRNA network. In our previous study, we observed the highest differential expression levels of lncRNA-CR11538
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Peripheral inflammation-induced changes in songbird brain gene expression: 3’ mRNA transcriptomic approach Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-25 Nithya Kuttiyarthu Veetil, Haniel Cedraz de Oliveira, Mercedes Gomez-Samblas, Daniel Divín, Balraj Melepat, Eleni Voukali, Zuzana Świderská, Tereza Krajzingrová, Martin Těšický, Ferris Jung, Vladimír Beneš, Ole Madsen, Michal Vinkler
Species-specific neural inflammation can be induced by profound immune signalling from periphery to brain. Recent advances in transcriptomics offer cost-effective approaches to study this regulation. In a population of captive zebra finch (Taeniopygia guttata), we compare the differential gene expression patterns in lipopolysaccharide (LPS)-triggered peripheral inflammation revealed by RNA-seq and
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Comprehensive analysis of circRNA-miRNA-mRNA networks in the kidney of snakehead (Channa argus) response to Nocardia seriolae challenge Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-23 Xiaoyan Zhang, Yanliang Jiang, Haohui Yu, Ningning Wang, Xiantong Liu, Min Cao, Chao Li
Non-coding RNAs (ncRNAs) play vital roles in regulating the expression levels of genes that control essential biological functions, including immune response to bacterial infections in teleost. To dissect the roles of ncRNAs in the Channa argus (snakehead), a systematic analysis of the expression profiles of circRNA, miRNA and mRNA, as well as competing endogenous RNAs (ceRNA) regulatory networks in
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Identification and expression analysis of Oxfibrillin gene involved in the regeneration process of Ophryotrocha xiamen (Annelida, Dorcilleidae) Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-22 Ruanni Chen, Yunying Cheng, Yuting Zhang, Jianming Chen
Regeneration of lost body parts is a widespread phenomenon across annelids. However, the molecular inducers of the cell sources for this reparative morphogenesis have not been identified. We have identified a regeneration-related gene Oxfibrillin from the transcriptome analysis of a polychaeta, Ophryotrocha xiamen, which is found to be a well-suited model to study the mechanisms of regeneration. Fibrillins
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The Lrp transcriptional factor of an entomopathogenic bacterium, Xenorhabdus hominickii, activates non-ribosomal peptide synthetases to suppress insect immunity Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-22 Gahyeon Jin, Il-Hwan Kim, Yonggyun Kim
Two bacterial genera, Xenorhabdus and Photorhabdus, are mutually symbiotic to the entomopathogenic nematodes, Steinernema and Heterorhabditis, respectively. The infective juveniles deliver the symbiotic bacteria to the hemocoel of target insects, in which the bacteria proliferate and help the development of the host nematode. The successful parasitism of the nematode-bacterial complex depends on host
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The goldfish primary kidney macrophage system Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-15 Xionglin Li, Xinyuan Yue, Jiasong Xie
Miodrag (Mike) Belosevic and collaborators profoundly influenced the development of primary kidney macrophage culturing system (PKM) to study fish immunology in various aspects of comparative immunology. Their application of using PKM model, opened a new path for studying the development of macrophages, regulation of hematopoiesis, and cell specific response against various pathogens. By measuring
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Corrigendum to “Receptor complex and signalling pathway of the two type II IFNs, IFN-γ and IFN-γrel in mandarin fish or the so-called Chinese perch Siniperca chuatis” [Dev. Comp. Immunol. 97 (2019) 98–112] Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-15 Li Li, Shan Nan Chen, Zubair Ahmed Laghari, Bei Huang, Hui Jun Huo, P. Nie
Abstract not available
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The antiviral effects of TRIM23 and TRIM32 proteins in rainbow trout (Oncorhynchus mykiss) Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-14 Mengmeng Zhang, Jinhui Sun, Yanxue Shi, Futing Zhang, Shuaibo Li, Dandan Zhao, Guangqing Wu, Linsong Li, Zhiruo Miao, Min Liu
TRIM proteins play a crucial antiviral effector role in the innate immune system of vertebrates. In this study, we found that TRIM proteins exhibited the highest expression levels in immune organs such as spleen and kidney during IHNV infection in rainbow trout, meanwhile, we successfully amplified TRIM23 and TRIM32 from diseased rainbow trout and analyzed their gene sequences, revealing that rainbow
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Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-11 Yu Huang, Tan Wang, Chun Jiang, Shengjie Li, Hongjian Zhou, Ruimin Li
Innate immunity plays a crucial role in host defense against pathogen invasion and its strength and duration requires precise control. Long non-coding RNAs (lncRNAs) have become important regulators of innate immunity, yet their roles in Drosophila immune responses remain largely unknown. In this study, we identified that the overexpression of lncRNA-CR11538 inhibits the expression of antimicrobial
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Dietary supplementation with pseudostellaria heterophylla polysaccharide enhanced immunity and changed mRNA expression of spleen in chicks Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-10 Zhaoyan Zhu, Yange Yu, Bingxin Wang, Mengxia Ding, Yadong Tian, Ruirui Jiang, Guirong Sun, Ruili Han, Xiangtao Kang, Fengbin Yan, Yujie Guo
In recent years, increasing interest has focused on natural components extracted from plants, among which plant polysaccharides as natural immunomodulators that can promote animal immunity. The present study was performed to investigate the effect of feed supplement Pseudostellaria Heterophylla Polysaccharide (PHP) on serum Immunoglobulins, T lymphocyte subpopulations, Cytokines and Lysozyme (LZM)
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Distribution and spatiotemporal development of organised lymphoid tissues in the chicken intestinal tract Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-10 Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Chickens exhibit a distinct immune architecture characterised by the absence of draining lymph nodes and the presence of a well-developed mucosa-associated lymphoid tissue. The structure and spatiotemporal development of chicken lymphoid tissues in the intestine are poorly documented. The macroscopically indistinct structure of chicken Peyer's patches has impeded studies into their development. The
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The expression, function, and network regulation of circDNAJB6 in chicken macrophages under lipopolysaccharide (LPS) stimulation Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-10 Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Circular RNAs (circRNA) originate from back-splicing events that link a downstream 5'splice site to an upstream 3′ splice site. Circular RNA has been shown to be involved in gene expression, interacting with microRNA and RNA binding proteins to affect transcription, splicing, translation, and other processes. However, little is known about the potential function of chicken circRNAs that trigger the
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Mechanisms of type I interferon production by chicken TLR21 Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-10 Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Mélanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
The innate immune response relies on the ability of host cells to rapidly detect and respond to microbial nucleic acids. Toll-like receptors (TLRs), a class of pattern recognition receptors (PRRs), play a fundamental role in distinguishing self from non-self at the molecular level. In this study, we focused on TLR21, an avian TLR that recognizes DNA motifs commonly found in bacterial genomic DNA, specifically
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Recent Contributions to Mechanisms of Innate Immunity of Fish Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-02 Pin Nie
Abstract not available
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Identification of an essential role against shrimp pathogens of prophenoloxidase activating enzyme 1 (PPAE1) from Fenneropenaeus merguiensis hemocytes Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-11-03 Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Prophenoloxidase (proPO) activating enzymes, known as PPAEs, are pivotal in activating the proPO system within invertebrate immunity. A cDNA encoding a PPAE derived from the hemocytes of banana shrimp, Fenneropenaeus merguiensis have cloned and analyzed, referred to as FmPPAE1. The open reading frame of FmPPAE1 encompasses 1392 base pairs, encoding a 464-amino acid peptide featuring a presumed 19-amino
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Retraction notice to “The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis” [Dev. Comp. Immunol. 59 (2016) 2532] Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-10-29 G.-G. Li, Z.-Z. Guo, X.-F. Ma, N. Cao, S.-N. Geng, Y.-Q. Zheng, M.-J. Meng, H.-H. Lin, G. Han, G.-J. Du
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). < This article has been retracted at the request of the Co-Editor-in-Chief after a complaint was registered on the PubPeer webpage (https://pubpeer.com/publications/2460573E8B5707B48D70D73FF31E54). The article duplicates images from a figure, with a 90o rotation
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The Yin Yang 1 of Penaeus vannamei regulates transcription of the small subunit hemocyanin gene during Vibrio parahaemolyticus infection Dev. Comp. Immunol. (IF 2.9) Pub Date : 2023-10-26 Peikui Yang, Xianliang Zhao, Jude Juventus Aweya, Yueling Zhang
Hemocyanin is a respiratory protein, it is also a multifunctional immune molecule that plays a vital role against pathogen invasion in shrimp. However, the regulation of hemocyanin gene expression in shrimp hemocytes and the mechanisms involved during pathogen infection remains unclear. Here, we used DNA pull-down followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the