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Btbd8 deficiency reduces susceptibility to colitis by enhancing intestinal barrier function and suppressing inflammation Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Xiaoqiong Yang, Zichan He, Qiman Dong, Shanshan Nai, Xiaowei Duan, Jiayu Yu, Nannan Zhao, Xiaoling Du, Lingyi Chen
IntroductionBTBD8 has been identified as a susceptible gene for inflammatory bowel diseases (IBD). However, the function of BTBD8 in normal development and IBD pathogenesis remains unknown.MethodsWe administered drinking water with 3% dextran sodium sulfate (DSS) to wild-type (WT) and Btbd8 knockout (KO) mice for seven consecutive days to induce IBD. Subsequently, we further examined whether Btbd8
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Integrated plasma metabolomic and cytokine analysis reveals a distinct immunometabolic signature in atopic dermatitis Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Emily Z. Ma, Junwen Deng, Varsha Parthasarathy, Kevin K. Lee, Thomas Pritchard, Shenghao Guo, Cissy Zhang, Madan M. Kwatra, Anne Le, Shawn G. Kwatra
ImportanceDisease models for atopic dermatitis (AD) have primarily focused on understanding underlying environmental, immunologic, and genetic etiologies. However, the role of metabolic mechanisms in AD remains understudied.ObjectiveTo investigate the circulating blood metabolomic and cytokine profile of AD as compared to healthy control patients.DesignThis study collected plasma from 20 atopic dermatitis
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Role of Treg cell subsets in cardiovascular disease pathogenesis and potential therapeutic targets Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Yuanliang Xia, Di Gao, Xu Wang, Bin Liu, Xue Shan, Yunpeng Sun, Dashi Ma
In the genesis and progression of cardiovascular diseases involving both innate and adaptive immune responses, inflammation plays a pivotal and dual role. Studies in experimental animals indicate that certain immune responses are protective, while others exacerbate the disease. T-helper (Th) 1 cell immune responses are recognized as key drivers of inflammatory progression in cardiovascular diseases
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Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis, Sofia Viana
Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and non-autoimmune mediated. The immune system regulates the functioning of cellular metabolism within organs like the brain, pancreas and/or adipose tissue by sensing and adapting to fluctuations in the microenvironment’s nutrients, thereby
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Biomarkers for prediction of CAR T therapy outcomes: current and future perspectives Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Lucija Levstek, Larisa Janžič, Alojz Ihan, Andreja Nataša Kopitar
Chimeric antigen receptor (CAR) T cell therapy holds enormous potential for the treatment of hematologic malignancies. Despite its benefits, it is still used as a second line of therapy, mainly because of its severe side effects and patient unresponsiveness. Numerous researchers worldwide have attempted to identify effective predictive biomarkers for early prediction of treatment outcomes and adverse
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Influence of microbiota-driven natural antibodies on dengue transmission Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Alejandra Wu-Chuang, Alejandra Rojas, Cynthia Bernal, Fátima Cardozo, Adriana Valenzuela, Cristina Romero, Lourdes Mateos-Hernández, Alejandro Cabezas-Cruz
Dengue has had a significant global health impact, with a dramatic increase in incidence over the past 50 years, affecting more than 100 countries. The absence of a specific treatment or widely applicable vaccine emphasizes the urgent need for innovative strategies. This perspective reevaluates current evidence supporting the concept of dual protection against the dengue virus (DENV) through natural
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Targeting the gut microbiota to enhance the antitumor efficacy and attenuate the toxicity of CAR-T cell therapy: a new hope? Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Peng-Fei Zhang, Dan Xie
Chimeric antigen receptor (CAR) -T cell therapy has achieved tremendous efficacy in the treatment of hematologic malignancies and represents a promising treatment regimen for cancer. Despite the striking response in patients with hematologic malignancies, most patients with solid tumors treated with CAR-T cells have a low response rate and experience major adverse effects, which indicates the need
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ARDS and aging: TYMS emerges as a promising biomarker and therapeutic target Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Gang Li, Ke Yan, Wanyi Zhang, Haiyan Pan, Pengxiang Guo
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a common condition in the intensive care unit (ICU) with a high mortality rate, yet the diagnosis rate remains low. Recent studies have increasingly highlighted the role of aging in the occurrence and progression of ARDS. This study is committed to investigating the pathogenic mechanisms of cellular and genetic changes in elderly ARDS patients
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The graft versus leukemia effect: donor lymphocyte infusions and cellular therapy Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Katie Maurer, Joseph H. Antin
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many hematologic malignancies as well as non-malignant conditions. Part of the curative basis underlying HSCT for hematologic malignancies relies upon induction of the graft versus leukemia (GVL) effect in which donor immune cells recognize and eliminate residual malignant cells within the recipient, thereby
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Identification of miRNAs that target Fcγ receptor-mediated phagocytosis during macrophage activation syndrome Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Kontham Kulangara Varsha, Xiaoming Yang, Alkeiver S. Cannon, Yin Zhong, Mitzi Nagarkatti, Prakash Nagarkatti
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile arthritis, accompanied by cytokine storm and hemophagocytosis. In addition, COVID-19–related hyperinflammation shares clinical features of MAS. Mechanisms that activate macrophages in MAS remain unclear. Here, we identify the role of miRNA in increased phagocytosis and interleukin-12 (IL-12) production by macrophages
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Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Jingyi Li, Yaping Dong, Feifei Chen, Hongyu Yang, Pei Chen, Hongyu Li, Sufang Shi, Xujie Zhou, Li Zhu, Yuemiao Zhang, Lijun Liu, Xinfang Xie, Feng Yu, Jing Jin, Jicheng Lv, Hong Zhang
IntroductionActivation of complement through the alternative pathway (AP) has a key role in the pathogenesis of IgA nephropathy (IgAN). We previously showed, by intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE), C57BL/6 mice develop mild kidney damage in association with glomerular IgA deposition. To further address complement activity in causing glomerular histological alterations
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Causal role of immune cells in psoriasis: a Mendelian randomization analysis Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Anning Wang, Jingyuan Zhang
BackgroundA growing body of evidence has shown that immune cells are linked to psoriasis. It is, however, still unclear if these associations reflect a relationship of cause and effect.ObjectiveWe employed a two-sample Mendelian randomization (MR)-based study to elucidate the probable causative connection between immune cells and psoriasis.MethodsSummary information for psoriasis (Ncase = 5,427, Ncontrol
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Effect of the gut microbiome, plasma metabolome, peripheral cells, and inflammatory cytokines on obesity: a bidirectional two-sample Mendelian randomization study and mediation analysis Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Ying Li, Xin Wang, Zitong Zhang, Lei Shi, Liang Cheng, Xue Zhang
BackgroundObesity is a metabolic and chronic inflammatory disease involving genetic and environmental factors. This study aimed to investigate the causal relationship among gut microbiota abundance, plasma metabolomics, peripheral cell (blood and immune cell) counts, inflammatory cytokines, and obesity.MethodsSummary statistics of 191 gut microbiota traits (N = 18,340), 1,400 plasma metabolite traits
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GD2-targeting therapy: a comparative analysis of approaches and promising directions Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Julia Philippova, Julia Shevchenko, Sergey Sennikov
Disialoganglioside GD2 is a promising target for immunotherapy with expression primarily restricted to neuroectodermal and epithelial tumor cells. Although its role in the maintenance and repair of neural tissue is well-established, its functions during normal organism development remain understudied. Meanwhile, studies have shown that GD2 plays an important role in tumorigenesis. Its functions include
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Rapid identification of inflammatory arthritis and associated adverse events following immune checkpoint therapy: a machine learning approach Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Steven D. Tran, Jean Lin, Carlos Galvez, Luke V. Rasmussen, Jennifer Pacheco, Giovanni M. Perottino, Kian J. Rahbari, Charles D. Miller, Jordan D. John, Jonathan Theros, Kelly Vogel, Patrick V. Dinh, Sara Malik, Umar Ramzan, Kyle Tegtmeyer, Nisha Mohindra, Jodi L. Johnson, Yuan Luo, Abel Kho, Jeffrey Sosman, Theresa L. Walunas
IntroductionImmune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) poses a major clinical challenge to ICI therapy for cancer, with 13% of cases halting ICI therapy and ICI-IA being difficult to identify for timely referral to a rheumatologist. The objective of this study was to rapidly identify ICI-IA patients in clinical data and assess associated immune-related adverse events (irAEs)
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Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Zhihong Chen, Jingang Zhang, Yongli Pan, Zhongnan Hao, Shuang Li
Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellular dynamics and protein production. The polarization of macrophages/microglia involves a pivotal impact in modulating the development of inflammatory
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The occurrence of immune-related adverse events is an independent risk factor both for serum HBsAg increase and HBV reactivation in HBsAg-positive cancer patients receiving PD-1 inhibitor combinational therapy Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Yingfu Zeng, Jiwei Huang, Jiahui Pang, Shufang Pan, Yuankai Wu, Yusheng Jie, Xinhua Li, Yutian Chong
BackgroundPrevious studies have suggested the potential of PD-1/PD-L1 inhibitors in the treatment of chronic HBV infection. However, since phase III clinical trials have not yet been announced, additional clinical insights may be obtained by observing changes in serum hepatitis B surface antigen (HBsAg) and HBV-DNA levels in cancer patients undergoing PD-1 inhibitor therapy.ObjectiveTo explore the
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Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Xinyong Liu, Longwang Chen, Wei Peng, Hongsheng Deng, Hongying Ni, Hongjie Tong, Hangbo Hu, Shengchao Wang, Jin Qian, Andong Liang, Kun Chen
Sepsis is a multi-organ dysfunction characterized by an unregulated host response to infection. It is associated with high morbidity, rapid disease progression, and high mortality. Current therapies mainly focus on symptomatic treatment, such as blood volume supplementation and antibiotic use, but their effectiveness is limited. Th17/Treg balance, based on its inflammatory property, plays a crucial
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Impact of glucocorticoids and rapamycin on autophagy in Candida glabrata-infected macrophages from BALB/c mice Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Zhenghui Yang, Xinyi Wang, Tianxiang Dong, Wei-Jia Zhao, Hongbin Li
ObjectiveIn the defense against microorganisms like Candida albicans, macrophages recruit LC3(Microtubule-associated protein 1A/1B-light chain 3) to the periplasm, engaging in the elimination process through the formation of a single-membrane phagosome known as LC3-associated phagocytosis (LAP). Building on this, we propose the hypothesis that glucocorticoids may hinder macrophage phagocytosis of Candida
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Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Christopher C. T. Sng, Ashwin Adrian Kallor, Benjamin S. Simpson, Georges Bedran, Javier Alfaro, Kevin Litchfield
BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy. Non-canonical neoantigens arising from the untranslated regions (UTR) of the genome are an overlooked source of immunogenic neoantigens. Here, we describe the landscape of UTR-derived
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Systemic Inflammatory Response Index (SIRI) is associated with all-cause mortality and cardiovascular mortality in population with chronic kidney disease: evidence from NHANES (2001–2018) Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Linguo Gu, Zhenkun Xia, Bei Qing, Wei Wang, Hongzuo Chen, Juan Wang, Ying Chen, Zhengling Gai, Rui Hu, Yunchang Yuan
ObjectiveTo examine the correlation between SIRI and the probability of cardiovascular mortality as well as all-cause mortality in individuals with chronic kidney disease.MethodsA cohort of 3,262 participants from the US National Health and Nutrition Examination Survey (NHANES) database were included in the study. We categorized participants into five groups based on the stage of chronic kidney disease
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Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Matthias J. Düchs, Ramona F. Kratzer, Pablo Vieyra-Garcia, Benjamin Strobel, Tanja Schönberger, Peter Groß, Ghaith Aljayyoussi, Aradhana Gupta, Isabel Lang, Holger Klein, Sandra Martinez Morilla, Stefan Hopf, John Park, Sebastian Kreuz, Matthias Klugmann, Frederik H. Igney
Hepatocellular carcinoma (HCC) and solid cancers with liver metastases are indications with high unmet medical need. Interleukin-12 (IL-12) is a proinflammatory cytokine with substantial anti-tumor properties, but its therapeutic potential has not been realized due to severe toxicity. Here, we show that orthotopic liver tumors in mice can be treated by targeting hepatocytes via systemic delivery of
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Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Oscar Bladh, Katherina Aguilera, Ulrika Marking, Martha Kihlgren, Nina Greilert Norin, Anna Smed-Sörensen, Margaret Sällberg Chen, Jonas Klingström, Kim Blom, Michael W. Russell, Sebastian Havervall, Charlotte Thålin, Mikael Åberg
IntroductionSeveral novel vaccine platforms aim at mucosal immunity in the respiratory tract to block SARS-CoV-2 transmission. Standardized methods for mucosal sample collection and quantification of mucosal antibodies are therefore urgently needed for harmonized comparisons and interpretations across mucosal vaccine trials and real-world data.MethodsUsing commercial electrochemiluminescence antibody
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Aging-related biomarker discovery in the era of immune checkpoint inhibitors for cancer patients Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Abdullah Al-Danakh, Mohammed Safi, Yuli Jian, Linlin Yang, Xinqing Zhu, Qiwei Chen, Kangkang Yang, Shujing Wang, Jianjun Zhang, Deyong Yang
Older patients with cancer, particularly those over 75 years of age, often experience poorer clinical outcomes compared to younger patients. This can be attributed to age-related comorbidities, weakened immune function, and reduced tolerance to treatment-related adverse effects. In the immune checkpoint inhibitors (ICI) era, age has emerged as an influential factor impacting the discovery of predictive
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Comprehensive analysis of fibroblast activation protein expression across 23 tumor indications: insights for biomarker development in cancer immunotherapies Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Sebastian Dziadek, Anton Kraxner, Wei-Yi Cheng, Tai-Hsien Ou Yang, Mike Flores, Noah Theiss, Tsu-Shuen Tsao, Emilia Andersson, Suzana Vega Harring, Ann-Marie E. Bröske, Maurizio Ceppi, Volker Teichgräber, Jehad Charo
IntroductionFibroblast activation protein (FAP) is predominantly upregulated in various tumor microenvironments and scarcely expressed in normal tissues.MethodsWe analyzed FAP across 1216 tissue samples covering 23 tumor types and 70 subtypes.ResultsElevated FAP levels were notable in breast, pancreatic, esophageal, and lung cancers. Using immunohistochemistry and RNAseq, a correlation between FAP
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Novel and potential future therapeutic options in systemic autoimmune diseases Front. Immunol. (IF 7.3) Pub Date : 2024-03-15 Lili Balogh, Katalin Oláh, Soma Sánta, Nóra Majerhoffer, Tamás Németh
Autoimmune inflammation is caused by the loss of tolerance to specific self-antigens and can result in organ-specific or systemic disorders. Systemic autoimmune diseases affect a significant portion of the population with an increasing rate of incidence, which means that is essential to have effective therapies to control these chronic disorders. Unfortunately, several patients with systemic autoimmune
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Adoptive T cell therapy for solid tumors: current landscape and future challenges Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Víctor Albarrán, María San Román, Javier Pozas, Jesús Chamorro, Diana Isabel Rosero, Patricia Guerrero, Juan Carlos Calvo, Carlos González, Coral García de Quevedo, Patricia Pérez de Aguado, Jaime Moreno, Alfonso Cortés, Ainara Soria
Adoptive cell therapy (ACT) comprises different strategies to enhance the activity of T lymphocytes and other effector cells that orchestrate the antitumor immune response, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) gene-modified T cells, and therapy with tumor-infiltrating lymphocytes (TILs). The outstanding results of CAR-T cells in some hematologic malignancies
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MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Elisha R. Verhaar, Anouk Knoflook, Novalia Pishesha, Xin Liu, Willemijn J. C. van Keizerswaard, Kai W. Wucherpfennig, Hidde L. Ploegh
MICA and MICB are Class I MHC-related glycoproteins that are upregulated on the surface of cells in response to stress, for instance due to infection or malignant transformation. MICA/B are ligands for NKG2D, an activating receptor on NK cells, CD8+ T cells, and γδ T cells. Upon engagement of MICA/B with NKG2D, these cytotoxic cells eradicate MICA/B-positive targets. MICA is frequently overexpressed
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Therapeutic potential of procathepsin L-inhibiting and progesterone-entrapping dimethyl-β-cyclodextrin nanoparticles in treating experimental sepsis Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Xiaoling Qiang, Weiqiang Chen, Cassie Shu Zhu, Jianhua Li, Timothy Qi, Li Lou, Ping Wang, Kevin J. Tracey, Haichao Wang
The pathogenic mechanisms of bacterial infections and resultant sepsis are partly attributed to dysregulated inflammatory responses sustained by some late-acting mediators including the procathepsin-L (pCTS-L). It was entirely unknown whether any compounds of the U.S. Drug Collection could suppress pCTS-L-induced inflammation, and pharmacologically be exploited into possible therapies. Here, we demonstrated
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Type I interferon pathway activation across the antiphospholipid syndrome spectrum: associations with disease subsets and systemic antiphospholipid syndrome presentation Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Irene Cecchi, Massimo Radin, Alice Barinotti, Silvia Grazietta Foddai, Elisa Menegatti, Dario Roccatello, Ana Suárez, Savino Sciascia, Javier Rodríguez-Carrio
IntroductionWhile the type I interferon (IFN-I) pathway is crucial in autoimmunity, its role in antiphospholipid antibody (aPL)-positive subjects, including aPL carriers and antiphospholipid syndrome (APS) patients, is poorly understood. This study aims at characterizing IFN-I pathway activation within the spectrum of aPL-positive subsets.MethodsA total of 112 patients [29 aPL carriers, 31 primary
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Immune checkpoint inhibitors combined with concurrent chemoradiotherapy in locally advanced esophageal squamous cell carcinoma Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Jiang-Qiong Huang, Huan-Wei Liang, Yang Liu, Long Chen, Su Pei, Bin-Bin Yu, Xin-Bin Pan
PurposeThis study aims to evaluate the efficacy of immune checkpoint inhibitors (ICIs) combined with concurrent chemoradiotherapy (CCRT) versus CCRT alone in patients with locally advanced esophageal squamous cell carcinoma.Materials and methodsThis retrospective cohort study included patients diagnosed with locally advanced esophageal squamous cell carcinoma who received either CCRT alone or CCRT
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STING agonist inflames the cervical cancer immune microenvironment and overcomes anti-PD-1 therapy resistance Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Tianye Li, Weijiang Zhang, Mengke Niu, Yuze Wu, Xinyue Deng, Jianwei Zhou
BackgroundCervical cancer poses a significant global threat to women’s health. However, current therapeutic interventions, such as radiotherapy, chemotherapy, surgical resection, and immune checkpoint inhibitors, face limitations in the advanced stages of the disease. Given the immunosuppressive microenvironment in cervical cancer, it is imperative to explore novel perspectives. In this regard, STING
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Targeting YAP1 to improve the efficacy of immune checkpoint inhibitors in liver cancer: mechanism and strategy Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yuting Gao, Yi Gong, Junlan Lu, Huiqin Hao, Xinli Shi
Liver cancer is the third leading of tumor death, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Immune checkpoint inhibitors (ICIs) are yielding much for sufferers to hope for patients, but only some patients with advanced liver tumor respond. Recent research showed that tumor microenvironment (TME) is critical for the effectiveness of ICIs in advanced liver tumor
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Mathematical modeling in autoimmune diseases: from theory to clinical application Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yaroslav Ugolkov, Antonina Nikitich, Cristina Leon, Gabriel Helmlinger, Kirill Peskov, Victor Sokolov, Alina Volkova
The research & development (R&D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. The number of targeted therapies available on the market is limited, whereas the prevalence of autoimmune conditions in the global population continues to rise. Mathematical modeling of biological systems is an
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Low-dose targeted radionuclide therapy synergizes with CAR T cells and enhances tumor response Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yanping Yang, Yogindra Vedvyas, Yago Alcaina, Ju Y. Son, Irene M. Min, Moonsoo M. Jin
Ionizing radiation has garnered considerable attention as a combination partner for immunotherapy due to its potential immunostimulatory effects. In contrast to the more commonly used external beam radiation, we explored the feasibility of combining chimeric antigen receptor (CAR) T cell therapy with targeted radionuclide therapy (TRT), which is achieved by delivering β-emitting 177Lu-DOTATATE to tumor
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Phenotype and function of MAIT cells in patients with alveolar echinococcosis Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Jintian Li, Hanyue Zhao, Guodong Lv, Kalibixiati Aimulajiang, Liang Li, Renyong Lin, Tuerganaili Aji
Mucosal-associated invariant T (MAIT) cells are a subpopulation of unconventional T cells widely involved in chronic liver diseases. However, the potential role and regulating factors of MAIT cells in alveolar echinococcosis (AE), a zoonotic parasitic disease by Echinococcus multilocularis (E. multilocularis) larvae chronically parasitizing liver organs, has not yet been studied. Blood samples (n=29)
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Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Frouwkje A. Politiek, Marjolein Turkenburg, Rob Ofman, Hans R. Waterham
ObjectiveBi-allelic pathogenic variants in the MVK gene, which encodes mevalonate kinase (MK), an essential enzyme in isoprenoid biosynthesis, cause the autoinflammatory metabolic disorder mevalonate kinase deficiency (MKD). We generated and characterized MK-deficient monocytic THP-1 cells to identify molecular and cellular mechanisms that contribute to the pro-inflammatory phenotype of MKD.MethodsUsing
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Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yibo Feng, Jiaqi Li, Xiaohui Mo, Qiang Ju
Macrophages serve as a pivotal nexus in the pathogenesis of acne vulgaris, orchestrating both the elimination of Cutibacterium acnes (C. acnes) and lipid metabolic regulation while also possessing the capacity to exacerbate inflammation and induce cutaneous scarring. Additionally, recent investigations underscore the therapeutic potential inherent in macrophage modulation and challenge current anti-inflammatory
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Plasma from patients undergoing allogeneic hematopoietic stem cell transplantation promotes NETOSIS in vitro and correlates with inflammatory parameters and clinical severity Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Bernardo López-Andrade, Vanesa Cunill, Valero Andreu, Leyre Bento, Marina Segura-Guerrero, Andrea Moñino, Julio Iglesias, Maria Rosa Julià, Maria Antonia Durán, Maria Carmen Ballester, Josep Muncunill, Antonia Sampol
IntroductionNETosis, the mechanism by which neutrophils release extracellular traps (NETs), is closely related to inflammation. During the allogeneic hematopoietic stem cell transplantation (allo-HSCT), different stimuli can induce NETs formation. Inflammation and endothelial injury have been associated with acute graft-versus-host disease (aGVHD) and complications after allo-HSCT. We focus on the
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Nanoparticle vaccines based on the receptor binding domain of porcine deltacoronavirus elicit robust protective immune responses in mice Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yuanhong Wang, Junhan Song, Xiaoying Deng, Junna Wang, Miao Zhang, Yun Liu, Pan Tang, Huili Liu, Yanjun Zhou, Guangzhi Tong, Guoxin Li, Lingxue Yu
BackgroundPorcine deltacoronavirus (PDCoV), a novel swine enteropathogenic coronavirus, challenges the global swine industry. Currently, there are no approaches preventing swine from PDCoV infection.MethodsA new PDCoV strain named JS2211 was isolated. Next, the dimer receptor binding domain of PDCoV spike protein (RBD-dimer) was expressed using the prokaryotic expression system, and a novel nanoparticle
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Mitochondrial extracellular vesicles, autoimmunity and myocarditis Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Damian N. Di Florio, Danielle J. Beetler, Elizabeth J. McCabe, Jon Sin, Tsuneya Ikezu, DeLisa Fairweather
For many decades viral infections have been suspected as ‘triggers’ of autoimmune disease, but mechanisms for how this could occur have been difficult to establish. Recent studies have shown that viral infections that are commonly associated with viral myocarditis and other autoimmune diseases such as coxsackievirus B3 (CVB3) and SARS-CoV-2 target mitochondria and are released from cells in mitochondrial
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The utility of Drosophila melanogaster as a fungal infection model Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Chengetai D. Mpamhanga, Ilias Kounatidis
Invasive fungal diseases have profound effects upon human health and are on increase globally. The World Health Organization (WHO) in 2022 published the fungal priority list calling for improved public health interventions and advance research. Drosophila melanogaster presents an excellent model system to dissect host-pathogen interactions and has been proved valuable to study immunopathogenesis of
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High normal alanine aminotransferase is an indicator for better response to antiviral therapy in chronic hepatitis B Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Chao Cai, Wen-Xuan Shang, En-Hua Lin, Yu-Chun Jiang, Hong Chen, Ke Xu, Lu Chen, Rui-Cong Chen, Yi-Jing Cai, Ji Lin, Ting-Chen Cai, Xiu-Li Lin, Lei Zhang, Nai-Bin Yang, Hui-Fang Zhang, Ming-Qin Lu
BackgroundEvidence shows people living with CHB even with a normal ALT (40U/L as threshold) suffer histological disease and there is still little research to evaluate the potential benefit of antiviral benefits in them.MethodsWe retrospectively examined 1352 patients who underwent liver biopsy from 2017 to 2021 and then obtained their 1-year follow-up data to analyze.ResultsALT levels were categorized
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Revisiting the immunopathology of congenital disorders of glycosylation: an updated review Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Carlota Pascoal, Rita Francisco, Patrícia Mexia, Beatriz Luís Pereira, Pedro Granjo, Helena Coelho, Mariana Barbosa, Vanessa dos Reis Ferreira, Paula Alexandra Videira
Glycosylation is a critical post-translational modification that plays a pivotal role in several biological processes, such as the immune response. Alterations in glycosylation can modulate the course of various pathologies, such as the case of congenital disorders of glycosylation (CDG), a group of more than 160 rare and complex genetic diseases. Although the link between glycosylation and immune
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Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Katarzyna Drzewicka, Zbigniew Zasłona
Metabolic changes are coupled with alteration in protein glycosylation. In this review, we will focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and sarcoidosis and thanks to their adaptable metabolism are an attractive therapeutic target. Examples presented in this review demonstrate that protein glycosylation regulates metabolism-driven immune responses in macrophages
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Unraveling the chicken T cell repertoire with enhanced genome annotation Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Simon P. Früh, Martin A. Früh, Benedikt B. Kaufer, Thomas W. Göbel
T cell receptor (TCR) repertoire sequencing has emerged as a powerful tool for understanding the diversity and functionality of T cells within the host immune system. Yet, the chicken TCR repertoire remains poorly understood due to incomplete genome annotation of the TCR loci, despite the importance of chickens in agriculture and as an immunological model. Here, we addressed this critical issue by
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Circulating tumor-associated antigen-specific IFNγ+4-1BB+ CD8+ T cells as peripheral biomarkers of treatment outcomes in patients with pancreatic cancer Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Hirotomo Murakami, Shokichi Takahama, Hirofumi Akita, Shogo Kobayashi, Yuji Masuta, Yuta Nagatsuka, Masaya Higashiguchi, Akira Tomokuni, Keiichi Yoshida, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi, Nariaki Matsuura, Takuya Yamamoto
CD8+ T cells affect the outcomes of pancreatic ductal adenocarcinoma (PDAC). Using tissue samples at pre-treatment to monitor the immune response is challenging, while blood samples are beneficial in overcoming this limitation. In this study, we measured peripheral antigen-specific CD8+ T cell responses against four different tumor-associated antigens (TAAs) in PDAC using flow cytometry and investigated
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Identification and validation of hub genes expressed in ulcerative colitis with metabolic dysfunction-associated steatotic liver disease Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yupei Liu, Jiao Li, Shan Tian, Qingzhi Lan, Zhiyi Sun, Chuan Liu, Weiguo Dong
ObjectiveUlcerative colitis (UC) and metabolic dysfunction-associated steatotic liver disease (MASLD) are closely intertwined; however, the precise molecular mechanisms governing their coexistence remain unclear.MethodsWe obtained UC (GSE75214) and MASLD (GSE151158) datasets from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were acquired by the ‘edgeR’ and ‘limma’
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SAP-expressing T peripheral helper cells identify systemic lupus erythematosus patients with lupus nephritis Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yevgeniya Gartshteyn, Laura Geraldino-Pardilla, Leila Khalili, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Anca D. Askanase, Adam Mor
IntroductionT follicular (TFH) and peripheral helper (TPH) cells have been increasingly recognized as a pathogenic subset of CD4 T cells in systemic lupus erythematosus (SLE). The SLAM Associated Protein (SAP) regulates TFH and TPH function by binding to the co-stimulatory signaling lymphocyte activation molecule family (SLAMF) receptors that mediate T cell - B cell interactions. SAP and SLAMF are
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A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yuan Wu, Mengfen Huang, Xueru Chen, Jingjing Wu, Li Li, Jianan Wei, Chuanjian Lu, Ling Han, Yue Lu
BackgroundObesity and dyslipidemia, major global health concerns, have been linked to psoriasis, but previous studies faced methodological limitations and their shared genetic basis remains unclear. This study examines various obesity-related and lipidemic traits as potential contributors to psoriasis development, aiming to clarify their genetic associations and potential causal links.MethodsSummary
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T-cell count and T-cell telomere length in patients with severe COVID-19 Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Bryan D. Kraft, Simon Verhulst, Tsung-Po Lai, Bruce A. Sullenger, Yunfei Wang, Wes Rountree, Lingye Chen, Christopher W. Woods, Thomas N. Denny, Abraham Aviv
Lymphocyte telomere length (TL) is highly variable and shortens with age. Short telomeres may impede TL-dependent T-cell clonal expansion with viral infection. As SARS-CoV-2 infection can induce prolonged and severe T-cell lymphopenia, infected adults, and particularly older adults with short telomeres, may display severe T-cell lymphopenia. To examine the relationship between T-cell TL parameters
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Discovering single cannabidiol or synergistic antitumor effects of cannabidiol and cytokine-induced killer cells on non-small cell lung cancer cells Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Yutao Li, Amit Sharma, Michèle J. Hoffmann, Dirk Skowasch, Markus Essler, Hans Weiher, Ingo G. H. Schmidt-Wolf
IntroductionA multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties of cannabidiol (CBD). Since CBD acts on multiple molecular targets, its clinical adaptation, especially in combination with cancer immunotherapy regimen remains a serious concern.MethodsConsidering this, we extensively studied the effect of CBD on the cytokine-induced killer
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Circadian disruption dysregulates lung gene expression associated with inflammatory lung injury Front. Immunol. (IF 7.3) Pub Date : 2024-03-14 Nancy G. Casanova, Richard L. De Armond, Saad Sammani, Xiaoguang Sun, Belinda Sun, Carrie Kempf, Christian Bime, Joe G. N. Garcia, Sairam Parthasarathy
RationaleCircadian systems drive the expression of multiple genes in nearly all cells and coordinate cellular-, tissue-, and system-level processes that are critical to innate immunity regulation.ObjectiveWe examined the effects of circadian rhythm disorganization, produced by light shift exposure, on innate immunity-mediated inflammatory lung responses including vascular permeability and gene expression
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HBsAg level defines different clinical phenotypes of HBeAg(−) chronic HBV infection related to HBV polymerase-specific CD8+ cell response quality Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Julia Peña-Asensio, Henar Calvo-Sánchez, Joaquín Miquel-Plaza, Eduardo Sanz-de-Villalobos, Alejandro González-Praetorius, Alberto Delgado-Fernandez, Miguel Torralba, Juan-Ramón Larrubia
BackgroundHBe-antigen(Ag)-negative chronic hepatitis B virus (HBV) infection is characterized by little liver fibrosis progression and vigorous HBV-multispecific CD8+ T-cell response.AimsTo assess whether HBsAg level could discriminate different HBeAg-negative chronic HBV infection subtypes with dissimilar quality of HBV-specific CD8+ T-cell response.MethodsWe recruited 63 HBeAg-negative chronic HBV
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Applications of emerging extracellular vesicles technologies in the treatment of inflammatory diseases Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Kecheng Lou, Hui Luo, Xinghua Jiang, Shangzhi Feng
The emerging extracellular vesicles technologies is an advanced therapeutic approach showing promising potential for addressing inflammatory diseases. These techniques have been proven to have positive effects on immune modulation and anti-inflammatory responses. With these advancements, a comprehensive review and update on the role of extracellular vesicles in inflammatory diseases have become timely
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The role of dermal fibroblasts in autoimmune skin diseases Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Zeqi Shi, Zhong Liu, Yujia Wei, Ri Zhang, Yunhua Deng, Dong Li
Fibroblasts are an important subset of mesenchymal cells in maintaining skin homeostasis and resisting harmful stimuli. Meanwhile, fibroblasts modulate immune cell function by secreting cytokines, thereby implicating their involvement in various dermatological conditions such as psoriasis, vitiligo, and atopic dermatitis. Recently, variations in the subtypes of fibroblasts and their expression profiles
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Recent progress in combination therapy of oncolytic vaccinia virus Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Seyedeh Nasim Mirbahari, Miles Da Silva, Abril Ixchel Muñoz Zúñiga, Nika Kooshki Zamani, Gabriel St-Laurent, Mehdi Totonchi, Taha Azad
In recent years, oncolytic viruses have emerged as promising agents for treating various cancers. An oncolytic virus is a non-pathogenic virus that, due to genetic manipulation, tends to replicate in and cause lysis of cancerous cells while leaving healthy cells unaffected. Among these viruses, vaccinia virus is an attractive platform for use as an oncolytic platform due to its 190 Kb genome with a
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Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Tomoaki Aoki, Vanessa Wong, Tai Yin, Eriko Nakamura, Yusuke Endo, Kei Hayashida, Simon C. Robson, Harshal Nandurkar, Betty Diamond, Sun Jung Kim, Atsushi Murao, Ping Wang, Lance B. Becker, Koichiro Shinozaki
BackgroundCardiac arrest (CA) is a significant public health concern. There is the high imminent mortality and survival in those who are resuscitated is substantively compromised by the post-CA syndrome (PCAS), characterized by multiorgan ischemia–reperfusion injury (IRI). The inflammatory response in PCAS is complex and involves various immune cell types, including lymphocytes and myeloid cells that
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C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Graciela Russomando, Diana Sanabria, Chyntia Carolina Díaz Acosta, Leticia Rojas, Laura Franco, Rossana Arenas, Giovanni Delogu, Mame Diarra Bousso Ndiaye, Rim Bayaa, Niaina Rakotosamimanana, Delia Goletti, Jonathan Hoffmann
IntroductionNew diagnostic tools are needed to rapidly assess the efficacy of pulmonary tuberculosis (PTB) treatment. The aim of this study was to evaluate several immune biomarkers in an observational and cross-sectional cohort study conducted in Paraguay.MethodsThirty-two patients with clinically and microbiologically confirmed PTB were evaluated before starting treatment (T0), after 2 months of
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Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology Front. Immunol. (IF 7.3) Pub Date : 2024-03-13 Xiaowen Lu, Zhan Shi, Lingling Jiang, Songying Zhang
Due to the physiological alteration during pregnancy, maternal gut microbiota changes following the metabolic processes. Recent studies have revealed that maternal gut microbiota is closely associated with the immune microenvironment in utero during pregnancy and plays a vital role in specific pregnancy complications, including preeclampsia, gestational diabetes, preterm birth and recurrent miscarriages