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Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study Immun. Ageing (IF 7.9) Pub Date : 2024-03-13 Lucy Kundura, Renaud Cezar, Sandrine Gimenez, Manuela Pastore, Christelle Reynes, Albert Sotto, Jacques Reynes, Clotilde Allavena, Laurence Meyer, Alain Makinson, Pierre Corbeau
People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune system is thought to fuel frailty, we characterized the immune activation profiles linked to frailty. We quantified twenty-seven activation markers in forty-six virological responders (four females and forty-two males; median age, 74 years; median duration of infection, 24 years; median
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Longevity-associated BPIFB4 gene counteracts the inflammatory signaling Immun. Ageing (IF 7.9) Pub Date : 2024-03-12 Monica Cattaneo, Andrea Baragetti, Alberto Malovini, Elena Ciaglia, Valentina Lopardo, Elena Olmastroni, Manuela Casula, Carolina Ciacci, Alberico L. Catapano, Annibale A. Puca
Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so called chronic low-grade inflammation, which contributes to a faster progression of aged-related cardiovascular (CV) diseases, including frailty, neurodegeneration, gastro-intestinal diseases and disorders reflected by alterations in the composition of gut microbiota. However, successful
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Immune aging in annual killifish Immun. Ageing (IF 7.9) Pub Date : 2024-03-08 Gabriele Morabito, Alina Ryabova, Dario Riccardo Valenzano
Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hallmarks that affect multiple organs. These hallmarks include protein aggregation, telomere shortening, cellular senescence, and systemic inflammation. Turquoise killifish possess the full spectrum of vertebrate-specific innate and adaptive immune system. However, during their recent
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Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients Immun. Ageing (IF 7.9) Pub Date : 2024-03-08 Mailton Prestes Madruga, Lucas Kich Grun, Letícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro R.T. Romão, Lucas Santos, José Claudio Fonseca Moreira, Vinicius Schenk Michaelsen, Marcelo Cypel, Marcos Otávio Brum Antunes, Marcus Herbert Jones,
Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and paracrine inflammation; and obesity has been associated with premature immunosenescence, microbial translocation, and dysfunctional innate immune responses leading to poor immune response against
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Correction: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice Immun. Ageing (IF 7.9) Pub Date : 2024-02-21 Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam M. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur, Eva L. Feldman
Correction: Immun Ageing 19, 67 (2022) https://doi.org/10.1186/s12979-022-00323-7 Following publication of the original article [1], the authors identified an error in the author name of Adam M. Allouch. The incorrect author name is: Adam A. Allouch. The correct author name is: Adam M. Allouch. The author group has been updated above and the original article [1] has been corrected. Henn RE, Elzinga
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Ageing on the impact of distribution about preformed anti-HLA and anti-MICA antibody specificities in recipients prior to initial HSCT from East China Immun. Ageing (IF 7.9) Pub Date : 2024-02-20 Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen, Xiaoyu Zhou
With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers of elderly patients were undergoing allogeneic HSCT and elderly patients with hematologic malignancies could benefit most from it. Preformed donor-specific human leukocyte antigen (HLA) antibodies (DSA) were associated with graft failure in HLA-mismatched allogeneic HSCT and the absence of DSA was
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The role of NLRP3 inflammasome in aging and age-related diseases Immun. Ageing (IF 7.9) Pub Date : 2024-02-05 Ruikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang, Peng Yu
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and mechanism related to aging like chronic low-grade inflammation. The NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response
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The interplay between obesity, immunosenescence, and insulin resistance Immun. Ageing (IF 7.9) Pub Date : 2024-02-05 Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery, Hamid Zand
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging. It has been shown that the adipocytes of obese individuals undergo cellular aging, known as senescence. Senescence can be transmitted to other normal cells through a series of chemical factors referred
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Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration Immun. Ageing (IF 7.9) Pub Date : 2024-02-03 Clement Shema, Yining Lu, Ling Wang, Yingze Zhang
Individual aged with various change in cell and cellular microenvironments and the skeletal system undergoes physiological changes that affect the process of bone fracture healing. These changes are accompanied by alterations in regulating critical genes involved in this healing process. Unfortunately, the elderly are particularly susceptible to hip bone fractures, which pose a significant burden associated
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Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and ZF2001 booster vaccine Immun. Ageing (IF 7.9) Pub Date : 2024-01-27 Yuwei Zhang, Lianxiang Zhao, Jinzhong Zhang, Xiaomei Zhang, Shanshan Han, Qingshuai Sun, Mingxiao Yao, Bo Pang, Qing Duan, Xiaolin Jiang
In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, we detected serum IgG antibodies and PBMC sample transcriptome profiles in 46 participants under 70 years old and 25 participants over 70 years old who received the third dose of the BBIBP-CorV
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Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis Immun. Ageing (IF 7.9) Pub Date : 2024-01-27 Hui-Hui Shen, Xin-Yan Zhang, Nan Liu, Yang-Yang Zhang, Hui-Hua Wu, Feng Xie, Wen-Jun Wang, Ming-Qing Li
Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian tissue homeostasis and immune surveillance. However, the impact of aging on ovarian macrophage function and ovarian homeostasis remains poorly understood. Senescence-associated beta-galactosidase staining, immunohistochemistry, and TUNEL staining were used to assess
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sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence Immun. Ageing (IF 7.9) Pub Date : 2024-01-20 Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin, Nuning Winaris
Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, especially those suffering from chronic inflammatory conditions such as autoimmune disease, malignancy, or chronic infection. This condition led to altered immune function and as consequent immune
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Correction: A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence Immun. Ageing (IF 7.9) Pub Date : 2024-01-16 Meng He, Jürgen Borlak
Correction: Immun Ageing 20, 58 (2023) https://doi.org/10.1186/s12979-023-00373-5 Following publication of the original article [1], the authors reported an error in the HTML version of this article. The graphical abstract displayed is not the correct image but, a copy of Fig. 10 and in addition Fig. 11 is not fully displayed. The publishers apologise for this error. The original article [1] has been
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Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor Immun. Ageing (IF 7.9) Pub Date : 2024-01-12 Agathe Crosland, Thierry Rigaud, Charlène Develay, Yannick Moret
The Disposable Soma Theory of aging suggests a trade-off between energy allocation for growth, reproduction and somatic maintenance, including immunity. While trade-offs between reproduction and immunity are well documented, those involving growth remain under-explored. Rapid growth might deplete resources, reducing investment in maintenance, potentially leading to earlier or faster senescence and
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Accelarated immune ageing is associated with COVID-19 disease severity Immun. Ageing (IF 7.9) Pub Date : 2024-01-11 Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling, Betty Raman, Michael Marks, Amisha Singapuri, Omer Elneima, Peter J. M. Openshaw, Niharika A. Duggal
The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and acute disease severity, we determined the immune phenotype of COVID-19 survivors and non-infected controls. We performed detailed immune phenotyping of peripheral blood
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Neuroimmunology and ageing – the state of the art Immun. Ageing (IF 7.9) Pub Date : 2024-01-10 Moisés E. Bauer, Graham Pawelec, Roberto Paganelli
For decades, the central nervous system (CNS) was known as an immune-privileged site. This concept was formulated based on experimental studies that demonstrated that, unlike what was observed in peripheral organs, skin grafts were not rejected when transplanted into the brain parenchyma. The presence of the blood-brain barrier (BBB), capable of selectively regulating the entry of molecules and cells
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Inflammatory markers and physical frailty: towards clinical application Immun. Ageing (IF 7.9) Pub Date : 2024-01-06 Yiming Pan, Lina Ma
Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and intervention of frailty, but the cellular mechanisms responsible for frailty are still not completely understood
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An aging-related immune landscape in the hematopoietic immune system Immun. Ageing (IF 7.9) Pub Date : 2024-01-02 Jianjie Lv, Chun Zhang, Xiuxing Liu, Chenyang Gu, Yidan Liu, Yuehan Gao, Zhaohao Huang, Qi Jiang, Binyao Chen, Daquan He, Tianfu Wang, Zhuping Xu, Wenru Su
Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, while the spleen, as the most important extramedullary hematopoietic immune organ, maintains homeostasis of the human hematopoietic immune system (HIS) in cooperation with the bone marrow. However
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Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions Immun. Ageing (IF 7.9) Pub Date : 2024-01-02 Cristina Rodriguez-Rodriguez, Natalia González-Mancha, Ane Ochoa-Echeverría, Rosa Liébana, Isabel Merida
Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive deficits due to impairment of AMPA and NMDA receptor recycling. Studies in human T cell lines likewise demonstrated that SNX27 regulates the correct delivery of cargoes to the immune synapse limiting
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Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability Immun. Ageing (IF 7.9) Pub Date : 2024-01-02 Bang-rong Wei, Yu-jia Zhao, Yu-feng Cheng, Chun Huang, Feng Zhang
Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence of PD has experienced a significant surge in recent years. The unidentified etiology poses limitations to the development of effective therapeutic interventions for this condition. Helicobacter pylori (H. pylori) infection has affected
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Blood circulating bacterial DNA in hospitalized old COVID-19 patients Immun. Ageing (IF 7.9) Pub Date : 2023-12-18 Robertina Giacconi, Patrizia D’Aquila, Maurizio Cardelli, Francesco Piacenza, Elisa Pierpaoli, Giada Sena, Mirko Di Rosa, Anna Rita Bonfigli, Roberta Galeazzi, Antonio Cherubini, Massimiliano Fedecostante, Riccardo Sarzani, Chiara Di Pentima, Piero Giordano, Roberto Antonicelli, Fabrizia Lattanzio, Giuseppe Passarino, Mauro Provinciali, Dina Bellizzi
Coronavirus disease COVID-19 is a heterogeneous condition caused by SARS-CoV-2 infection. Generally, it is characterized by interstitial pneumonia that can lead to impaired gas-exchange, acute respiratory failure, and death, although a complex disorder of multi-organ dysfunction has also been described. The pathogenesis is complex, and a variable combination of factors has been described in critically
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The inter-link of ageing, cancer and immunity: findings from real-world retrospective study Immun. Ageing (IF 7.9) Pub Date : 2023-12-15 Xiaomin Fu, Peng Qin, Fanghui Li, Huifang Zhu, Hongqin You, Yong Zhang, Benling Xu, Tiepeng Li, Fang Zhang, Lu Han, Lingdi Zhao, Baozhen Ma, Zibing Wang, Quanli Gao
Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical studies focusing on analysis of the peripheral blood immune changes underlying ageing, immunity and cancer are scarce. In this case-control study, we retrospectively analysed 1375 cancer patients and enrolled 275 age and gender matched healthy individuals. Flow cytometry was conducted
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IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice Immun. Ageing (IF 7.9) Pub Date : 2023-12-14 Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao, Peichang Wang
Alzheimer’s disease (AD), which is the most common cause of dementia in elderly individuals, is a progressive neurodegenerative disorder. Neuroinflammation, which is an immune response that is activated by glial cells in the central nervous system, plays an important role in neurodegenerative diseases. Many studies have shown that interleukin-17A (IL-17A) plays an important role in AD, but research
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The effect of metformin on senescence of T lymphocytes Immun. Ageing (IF 7.9) Pub Date : 2023-12-12 Jia Yang, Hai-Cheng Liu, Jian-Qing Zhang, Jian-Yong Zou, Xin Zhang, Wo-Ming Chen, Yong Gu, Hai Hong
Immunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent T cells also rises with age. T cell senescence and immune response dysfunction can result in a decline in immune function, especially in anti-tumor immune responses. Metformin has been shown to have various beneficial effects on health, such as lowering blood sugar levels, reducing
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Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus Immun. Ageing (IF 7.9) Pub Date : 2023-12-05 Shogo Ijima, Yuki Saito, Sena Yamamoto, Kentaro Nagaoka, Taiki Iwamoto, Arisa Kita, Maki Miyajima, Tsukasa Sato, Akihiro Miyazaki, Takako S. Chikenji
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently, therapeutic interventions for oral lichen planus are limited to symptomatic management. This study provides evidence of the accumulation of senescent mesenchymal cells, CD8 + T cells, and natural killer cells in patients with oral lichen planus. We profiled
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Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease Immun. Ageing (IF 7.9) Pub Date : 2023-12-02 Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You, Insoo Kang
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its gene signature (i.e., IL-7Rαlow aging genes) in peripheral blood of older adults without Alzheimer’s disease (AD). Considering age as the strongest risk factor for AD and the recent finding of
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Impact of NAD+ metabolism on ovarian aging Immun. Ageing (IF 7.9) Pub Date : 2023-12-02 Jinghui Liang, Feiling Huang, Zhaoqi Song, Ruiyi Tang, Peng Zhang, Rong Chen
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-related functional degeneration and metabolic diseases. NAD exerts direct and indirect influences on many crucial cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cellular senescence, and immune cell functionality. These cellular processes and functions
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Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective Immun. Ageing (IF 7.9) Pub Date : 2023-11-29 Sean X. Leng, Albert C. Shaw
Seasonal influenza is a common respiratory viral infection with the highest burden of severe disease and death affecting older adults worldwide. Annual immunization is the cornerstone for influenza prevention. However, despite the availability of influenza vaccines specially formulated for older adults, vaccination coverage varies widely among different countries/regions and older adults continue to
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Frailty is related to serum inflammageing markers: results from the VITAL study Immun. Ageing (IF 7.9) Pub Date : 2023-11-27 Yannick van Sleen, Sudarshan A. Shetty, Marieke van der Heiden, Milou C. A. Venema, Nicolas Gutiérrez-Melo, Erik J. M. Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle, Delphine Sauce
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing)
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Toll-like receptor 4 (TLR4): new insight immune and aging Immun. Ageing (IF 7.9) Pub Date : 2023-11-24 Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee, Cheol Hwangbo
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation of pro-inflammatory
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Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway Immun. Ageing (IF 7.9) Pub Date : 2023-11-21 Yahong Fu, Qiaowei Jia, Mengmeng Ren, Hengjie Bie, Xin Zhang, Qian Zhang, Shu He, Chengcheng Li, Hanxiao Zhou, Yanjun Wang, Xiongkang Gan, Zhengxian Tao, Xiumei Chen, Enzhi Jia
CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to be a diagnostic biomarker for CAD. However, the specific function and detailed mechanism of circZBTB46 in CAD are still unknown. The expression levels and properties of circRNAs were examined using qRT‒PCR, RNA FISH, and subcellular localization analysis. ApoE−/− mice fed a high-fat
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Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions Immun. Ageing (IF 7.9) Pub Date : 2023-11-20 Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen, Heping Xu
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to the growth of abnormal blood vessels into the macula, leading to the loss of central vision. Intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors (e.g., anti-VEGF) is the standard of care for nAMD. However, nearly 50% of patients do not respond or respond
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Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly Immun. Ageing (IF 7.9) Pub Date : 2023-11-20 Coralie Fonte, Pauline Jacob, Anne Vanet, Stéphanie Ghislin, Jean-Pol Frippiat
The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned long-duration missions, such as the deployment of the Lunar Gateway and possible interplanetary missions, it is mandatory to determine how all components of the immune system are affected, which will allow the establishment of countermeasures to preserve astronaut health
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Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia Immun. Ageing (IF 7.9) Pub Date : 2023-11-17 Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M. Hatch, Ming Zhang, Li Chen
Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remains to be further explored. In this study, we investigated the effect of an exercise-induced metabolite, lactate, on the microglia phenotype and its association with learning and memory. Microglia
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Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk Immun. Ageing (IF 7.9) Pub Date : 2023-11-17 Rubén Martín-Escolano, Erick Joan Vidal-Alcántara, Javier Crespo, Pablo Ryan, Luis Miguel Real, Juan Ignacio Lazo-Álvarez, Joaquín Cabezas-González, Juan Macías, María Teresa Arias-Loste, Guillermo Cuevas, Ana Virseda-Berdices, Veronica Briz, Salvador Resino, María Ángeles Jiménez-Sousa, Amanda Fernández-Rodríguez
About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but may remain at risk of inflammaging, aging, and liver and non-liver disease complications. This study evaluated the differences in the plasma levels of immune checkpoints (ICs) and senescence-associated secretory phenotype (SASP) biomarkers between patients who had
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Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome Immun. Ageing (IF 7.9) Pub Date : 2023-11-14 Tomasz Kmiołek, Gabriela Filipowicz, Diana Bogucka, Anna Wajda, Adam Ejma-Multański, Barbara Stypińska, Ewa Modzelewska, Yana Kaliberda, Marcin Radkowski, Tomasz Targowski, Julia Wrona, Agnieszka Paradowska-Gorycka
Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatric conditions with overlapping phenotypes. Many mechanisms are involved in the aging process such as DNA methylation telomeres which are susceptible to oxidative stress, and inflammations which result in telomere shortening, leading to chromosomal instability. The study aimed to
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Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health Immun. Ageing (IF 7.9) Pub Date : 2023-11-11 Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander, Magali Saint-Geniez
Correction: Immun Ageing 20, 53 (2023) https://doi.org/10.1186/s12979-023-00358-4 Following publication of the original article [1], the authors reported an error in the article title. The word “loss” should be removed. The correct article title should be “Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health”. The original article [1] has been updated
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TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease Immun. Ageing (IF 7.9) Pub Date : 2023-11-10 S. R. Fatemi Langroudi, M. Zeinaly, F. Ajamian
The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized. Genome-wide association studies (GWAS) have recently identified several candidate immune genes linked to development of both Alzheimer’s disease (AD) and depression. TBX21 (T-bet) which drives the Th1 immune response, is linked to the major depressive disorder (MDD) phenotype
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A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence Immun. Ageing (IF 7.9) Pub Date : 2023-11-06 Meng He, Jürgen Borlak
The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a lifetime exposure to antigens results in structural and functional changes of the lung; yet an understanding of the cell type specific responses remains elusive. To gain insight into age-related changes in lung function and inflammaging, we evaluated 89 mouse and 414
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Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study Immun. Ageing (IF 7.9) Pub Date : 2023-10-25 Yunus Kuijpers, H. Susan J. Picavet, Lia de Rond, Mary-lène de Zeeuw-Brouwer, Ryanne Rutkens, Esther Gijsbers, Irene Slits, Peter Engelfriet, Anne-Marie Buisman, W. M. Monique Verschuren
Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related variables potentially underlying the antibody responses to SARS-CoV-2 vaccination in older persons. We recruited participants in the long-running Doetinchem Cohort Study (DCS) who underwent vaccination as part of the national COVID-19 program, and measured antibody concentrations to
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Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways Immun. Ageing (IF 7.9) Pub Date : 2023-10-23 Ji-Su Baek, Yoon-Jung Shin, Xiaoyang Ma, Hee-Seo Park, Yun-Ha Hwang, Dong-Hyun Kim
Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics Lactobacillus paracasei P62 (Lp) and Bifidobacterium bifidum P61 (Bb), which suppressed muscle RING-finger protein-1 (MuRF1) expression and NF-κB activation in C2C12 cells, and examined their effects on muscle mass loss and dysfunction in aged mice. Oral administration of Lp, Bb
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Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults Immun. Ageing (IF 7.9) Pub Date : 2023-10-18 Bernardo Abel Cedeno-Veloz, Lucía Lozano-Vicario, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Enrique Santamaría, Alba Rodríguez-García, Roman Romero-Ortuno, Jaime Mondragon-Rubio, Javier Ruiz-Ruiz, Robinson Ramírez-Vélez, Mikel Izquierdo, Nicolás Martínez-Velilla
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In this observational study, we aimed to explore the association
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Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing Immun. Ageing (IF 7.9) Pub Date : 2023-10-17 Yining Lu, Yang Luo, Qi Zhang, Wei Chen, Ning Zhang, Ling Wang, Yingze Zhang
Hip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hidden blood loss and stress due to concealed injury sites could impact the whole osteoimmune microenvironment. This study employs scRNA-seq technique to map immune profiles in elderly hip fracture patients from post-trauma to the recovery period, investigating the dynamic changes
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Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health Immun. Ageing (IF 7.9) Pub Date : 2023-10-14 Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander, Magali Saint-Geniez
Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degeneration (AMD). Understanding the changes that occur in the eye due to aging is important in enhancing our understanding of AMD pathogenesis and the development of novel AMD therapies. Microglia, the resident brain and retinal immune cells are associated with both maintaining homeostasis
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Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients Immun. Ageing (IF 7.9) Pub Date : 2023-10-14 Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Regen
Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD). Whether changes in the tissue environment caused by circulatory factors associated with aging may alter the innate immune response is unknown. Monocyte-derived macrophages (Mo-MФs) infiltrating
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Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis Immun. Ageing (IF 7.9) Pub Date : 2023-10-11 L K Grun, R M Maurmann, J N Scholl, M E Fogaça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma, F M Barbé-Tuana
Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, with progressive accumulation of senescent cells and compromised ADSC function. In this study, we aimed to explore mechanisms associated with the inflammatory environment present in obesity in modulating
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Transcriptional characteristics and functional validation of three monocyte subsets during aging Immun. Ageing (IF 7.9) Pub Date : 2023-09-27 Chen Wang, Yating Cheng, Boyu Li, Xueping Qiu, Hui Hu, Xiaokang Zhang, Zhibing Lu, Fang Zheng
Age-associated changes in immunity are inextricably linked to chronic inflammation and age-related diseases, the impact of aging on monocyte subsets is poorly understood. Flow cytometry was applied to distinguish three monocyte subsets between 120 young and 103 aged individuals. We then analyzed the expression profiles of three monocyte subsets from 9 young and 9 older donors and CD14+ monocytes from
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Towards a better preclinical cancer model – human immune aging in humanized mice Immun. Ageing (IF 7.9) Pub Date : 2023-09-27 Joel H. L. Tan, You Yi Hwang, Hui Xian Chin, Min Liu, Sue Yee Tan, Qingfeng Chen
Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly improved with mice bearing a human immune system, especially in the context of immunotherapy. Nonetheless, cancer is an age-related disease, and studies often overlook the effects of aging. Here we have established a humanized mouse model of human immune aging to investigate
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Related factors of renal injury in primary Sjögren's syndrome Immun. Ageing (IF 7.9) Pub Date : 2023-09-21 Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang, Haixia Li
Primary Sjögren’s syndrome (pSS) is a common chronic systemic autoimmune disorder which primarily affects the exocrine glands. Patients may have extraglandular disease involving multiple organs, including the kidneys. This study aimed at investigating the clinical data and laboratory markers which were associated with renal function damage or renal involvement. One thousand two hundred eighty-eight
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Association between body fat distribution and B-lymphocyte subsets in peripheral blood Immun. Ageing (IF 7.9) Pub Date : 2023-09-13 Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-Hoffmann, Jakob Linseisen, Christa Meisinger, Dennis Freuer
Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship between adipose tissue and the immune system, it can be speculated that the accumulation of fat may influence the frequency and phenotype of lymphocyte populations. The aim of our study was to
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Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study Immun. Ageing (IF 7.9) Pub Date : 2023-09-04 Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Luigi Ferrucci
Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar levels in steady state condition during adult age. Neutrophils to lymphocytes-ratio (NL-ratio) was proposed as an effective and low-cost marker to monitor and predict the evolution of several
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Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population Immun. Ageing (IF 7.9) Pub Date : 2023-08-31 Mårten Sandstedt, Rosanna W S Chung, Camilla Skoglund, Anna K. Lundberg, Carl Johan Östgren, Jan Ernerudh, Lena Jonasson
Fatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is emerging evidence that thymic involution is linked to T cell aging, chronic inflammation and increased morbidity. Other factors, aside from chronological age, have been proposed to affect the involution rate. In the present study, we investigated the imaging characteristics of thymus
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Short-term intensive fasting enhances the immune function of red blood cells in humans Immun. Ageing (IF 7.9) Pub Date : 2023-08-30 Yixuan Fang, Jiawei Qian, Li Xu, Wen Wei, Wenwen Bu, Suping Zhang, Yaqi Lv, Lei Li, Chen Zhao, Xueqin Gao, Yue Gu, Li Wang, Zixing Chen, Xiao Wang, Ruizhi Zhang, Youjia Xu, Yanjun Yang, Jie Lu, Zhanjun Yan, Mingyuan Wang, Longhai Tang, Na Yuan, Jianrong Wang
Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the bone marrow and the peripheral tissues or circulation, in particular via relocalization of leukocytes back in the bone marrow. However, how the immune system responds to the increased risk of invasion by infectious pathogens with fewer leukocytes in the peripheral
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The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults Immun. Ageing (IF 7.9) Pub Date : 2023-08-29 Janna R. Shapiro, Kumba Seddu, Han-Sol Park, John S. Lee, Patrick S. Creisher, Anna Yin, Patrick Shea, Helen Kuo, Huifen Li, Engle Abrams, Sean X. Leng, Rosemary Morgan, Sabra L. Klein
Women/females report more adverse events (AE) following immunization than men/males for many vaccines, including the influenza and COVID-19 vaccines. This discrepancy is often dismissed as a reporting bias, yet the relative contributions of biological sex and gender are poorly understood. We investigated the roles of sex and gender in the rate of AE following administration of the high-dose seasonal
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Kinetics of COVID-19 mRNA primary and booster vaccine-associated neutralizing activity against SARS-CoV-2 variants of concern in long-term care facility residents: a prospective longitudinal study in Japan Immun. Ageing (IF 7.9) Pub Date : 2023-08-17 Tomoyuki Kakugawa, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano, Yusuke Mimura, Kazuto Matsunaga
Coronavirus disease 2019 (COVID-19) remains a threat to vulnerable populations such as long-term care facility (LTCF) residents, who are often older, severely frail, and have multiple comorbidities. Although associations have been investigated between COVID-19 mRNA vaccine immunogenicity, durability, and response to booster vaccination and chronological age, data on the association of clinical factors
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Systemic immune response in young and elderly patients after traumatic brain injury Immun. Ageing (IF 7.9) Pub Date : 2023-08-12 Marta Magatti, Francesca Pischiutta, Fabrizio Ortolano, Anna Pasotti, Enrico Caruso, Anna Cargnoni, Andrea Papait, Franco Capuzzi, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Stefano Borsa, Marco Locatelli, Elisa Erba, Daniele Prati, Antonietta R Silini, Elisa R Zanier, Ornella Parolini
Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain damage, systemic immune alterations occur, with evidence for dysregulated immune responses in aggravating TBI outcome and complications. However, immune dysfunction following TBI has been only partially understood, especially in the elderly who represent a substantial proportion
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Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection Immun. Ageing (IF 7.9) Pub Date : 2023-08-01 Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer, John V. Williams
Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositivity, antibodies fail to effectively protect the elderly. Therefore, we hypothesized that severe respiratory illness in the elderly is due to deficient CD8+ T cell responses. Here, we establish
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The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease Immun. Ageing (IF 7.9) Pub Date : 2023-07-31 Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu
More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD) and the plasma Aβ1-42 levels significantly increased 15 years before the onset of dominantly inherited AD. However, the effects of high plasma levels of Aβ1-42 on mononuclear macrophage, the peripheral counterparts of microglia, remain unclear. In the present study, we used APP/PS1
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Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older Immun. Ageing (IF 7.9) Pub Date : 2023-07-31 Bettina Wunderlich, Thomas Laskow, Huifen Li, Li Zhang, Engle Abrams, Jing Tian, Jun Yu, Yiyin Chen, Juliette Tavenier, Yushu Huang, Kawsar Talaat, Jay H. Bream, Qian-Li Xue, Graham Pawelec, Sean X. Leng
Seasonal influenza causes significant morbidity and mortality with a disproportionately high disease burden in older adults. Strain-specific hemagglutination-inhibition (HAI) antibody titer is a well-established measure of humoral immunity against influenza and pre-vaccination HAI titer is a valuable indicator of pre-existing humoral immunity at the beginning of each influenza season in highly vaccinated
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Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor Immun. Ageing (IF 7.9) Pub Date : 2023-07-27 Tongling Xiao, Miaomiao Wei, Xiaokun Guo, Yu Zhang, Zhongyan Wang, Xiaoshuang Xia, Xuemei Qi, Lin Wang, Xin Li, Sean X. Leng
Older adults are more vulnerable to seasonal influenza than younger adults. The immune responses of older persons to the influenza vaccine are usually poorer than those of young individuals, which is hypothesized due to immunosenescence. We conducted a study to evaluate the immunogenicity and safety of a quadrivalent inactivated influenza vaccine (IIV4) in a total of 167 young (< 65 years, n = 79)